ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	7.78047164
2	translational termination (GO:0006415)	7.51074621
3	ribosomal small subunit assembly (GO:0000028)	7.50193016
4	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	7.09031164
5	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.97903272
6	ATP synthesis coupled proton transport (GO:0015986)	6.97903272
7	maturation of SSU-rRNA (GO:0030490)	6.77123612
8	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	6.60573064
9	cotranslational protein targeting to membrane (GO:0006613)	6.49706899
10	protein targeting to ER (GO:0045047)	6.46935559
11	translational elongation (GO:0006414)	6.22015679
12	establishment of protein localization to endoplasmic reticulum (GO:0072599)	6.21412604
13	protein localization to endoplasmic reticulum (GO:0070972)	6.04279650
14	cellular protein complex disassembly (GO:0043624)	5.80289949
15	viral life cycle (GO:0019058)	5.70059037
16	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.66143812
17	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	5.17801855
18	translational initiation (GO:0006413)	5.08073138
19	ribosomal small subunit biogenesis (GO:0042274)	5.05059154
20	protein neddylation (GO:0045116)	5.03755930
21	respiratory electron transport chain (GO:0022904)	4.95006783
22	protein complex disassembly (GO:0043241)	4.88281580
23	electron transport chain (GO:0022900)	4.83885656
24	ribosomal large subunit biogenesis (GO:0042273)	4.73668198
25	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.73401505
26	macromolecular complex disassembly (GO:0032984)	4.55513839
27	GTP biosynthetic process (GO:0006183)	4.33696720
28	chaperone-mediated protein transport (GO:0072321)	4.28760698
29	protein targeting to membrane (GO:0006612)	4.19667836
30	translation (GO:0006412)	4.18593206
31	nuclear-transcribed mRNA catabolic process (GO:0000956)	4.12263217
32	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	4.00177510
33	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.96998928
34	protein complex biogenesis (GO:0070271)	3.92187056
35	mRNA catabolic process (GO:0006402)	3.91649340
36	ATP biosynthetic process (GO:0006754)	3.89592496
37	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.86709878
38	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.86709878
39	NADH dehydrogenase complex assembly (GO:0010257)	3.86709878
40	hydrogen ion transmembrane transport (GO:1902600)	3.66823912
41	UTP biosynthetic process (GO:0006228)	3.65859891
42	mitochondrial respiratory chain complex assembly (GO:0033108)	3.61419554
43	hindbrain development (GO:0030902)	3.55656485
44	RNA catabolic process (GO:0006401)	3.51130647
45	midbrain development (GO:0030901)	3.50324002
46	proton transport (GO:0015992)	3.49698741
47	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.46972843
48	hydrogen transport (GO:0006818)	3.43735297
49	spliceosomal complex assembly (GO:0000245)	3.43203972
50	UTP metabolic process (GO:0046051)	3.42451093
51	behavioral response to nicotine (GO:0035095)	3.41889336
52	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.36494008
53	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.36494008
54	thalamus development (GO:0021794)	3.27403565
55	protein K6-linked ubiquitination (GO:0085020)	3.27232303
56	water-soluble vitamin biosynthetic process (GO:0042364)	3.24504466
57	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.24213816
58	dopaminergic neuron differentiation (GO:0071542)	3.14402308
59	nucleoside triphosphate biosynthetic process (GO:0009142)	3.12228992
60	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.10390638
61	regulation of mitochondrial translation (GO:0070129)	3.09123909
62	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.02629866
63	cellular component biogenesis (GO:0044085)	2.99860281
64	nucleoside diphosphate phosphorylation (GO:0006165)	2.98847347
65	CTP metabolic process (GO:0046036)	2.98479200
66	CTP biosynthetic process (GO:0006241)	2.98479200
67	spliceosomal snRNP assembly (GO:0000387)	2.97690255
68	mismatch repair (GO:0006298)	2.95389963
69	inner mitochondrial membrane organization (GO:0007007)	2.92530545
70	positive regulation of gastrulation (GO:2000543)	2.92384349
71	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.91328178
72	protein-cofactor linkage (GO:0018065)	2.89955019
73	ribonucleoprotein complex biogenesis (GO:0022613)	2.88788336
74	somite development (GO:0061053)	2.88484703
75	base-excision repair, AP site formation (GO:0006285)	2.87040683
76	guanosine-containing compound biosynthetic process (GO:1901070)	2.82533640
77	establishment of protein localization to membrane (GO:0090150)	2.79029646
78	purine nucleoside monophosphate biosynthetic process (GO:0009127)	2.77545713
79	purine ribonucleoside monophosphate biosynthetic process (GO:0009168)	2.77545713
80	aldehyde catabolic process (GO:0046185)	2.74508196
81	proteasome assembly (GO:0043248)	2.74346954
82	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.74076497
83	protein targeting (GO:0006605)	2.70489111
84	urogenital system development (GO:0001655)	2.68339318
85	lateral sprouting from an epithelium (GO:0060601)	2.68050369
86	GPI anchor metabolic process (GO:0006505)	2.67113676
87	serine family amino acid catabolic process (GO:0009071)	2.66184653
88	DNA damage response, detection of DNA damage (GO:0042769)	2.64317927
89	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.63025397
90	DNA deamination (GO:0045006)	2.62369025
91	signal peptide processing (GO:0006465)	2.62021448
92	maturation of 5.8S rRNA (GO:0000460)	2.61660707
93	establishment of protein localization to organelle (GO:0072594)	2.61503288
94	GPI anchor biosynthetic process (GO:0006506)	2.60570730
95	oxidative phosphorylation (GO:0006119)	2.58270669
96	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.56998019
97	preassembly of GPI anchor in ER membrane (GO:0016254)	2.56556017
98	rRNA processing (GO:0006364)	2.52904270
99	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.51517284
100	pyrimidine nucleotide catabolic process (GO:0006244)	2.48412403

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.20715734
2	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.99041649
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.77736858
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.58677370
5	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.36079503
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.12946057
7	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.69004531
8	ELK1_19687146_ChIP-ChIP_HELA_Human	2.63051997
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.54999389
10	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.54981314
11	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.53731497
12	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.42369389
13	EZH2_22144423_ChIP-Seq_EOC_Human	2.37876580
14	EWS_26573619_Chip-Seq_HEK293_Human	2.33293757
15	VDR_23849224_ChIP-Seq_CD4+_Human	2.28200361
16	VDR_22108803_ChIP-Seq_LS180_Human	2.22386090
17	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.19229863
18	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.18278301
19	IGF1R_20145208_ChIP-Seq_DFB_Human	2.09653821
20	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.08640929
21	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.05104834
22	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.96510503
23	TTF2_22483619_ChIP-Seq_HELA_Human	1.96474551
24	MYC_18940864_ChIP-ChIP_HL60_Human	1.87465668
25	FUS_26573619_Chip-Seq_HEK293_Human	1.77838851
26	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.73455520
27	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.72122485
28	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.71733152
29	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.68180373
30	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.68047322
31	XRN2_22483619_ChIP-Seq_HELA_Human	1.68028620
32	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.56087393
33	TP53_22573176_ChIP-Seq_HFKS_Human	1.55606209
34	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.54010589
35	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.52928275
36	FOXP3_21729870_ChIP-Seq_TREG_Human	1.52140101
37	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.51231629
38	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.49327628
39	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.46376424
40	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.45891676
41	RNF2_27304074_Chip-Seq_NSC_Mouse	1.45379218
42	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.45089189
43	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.43743164
44	IRF1_19129219_ChIP-ChIP_H3396_Human	1.42933700
45	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.42547181
46	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.39749992
47	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.33276193
48	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.33239623
49	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.29943753
50	P300_19829295_ChIP-Seq_ESCs_Human	1.29846361
51	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.28514219
52	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.28514219
53	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.25012551
54	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.20316616
55	SOX2_19829295_ChIP-Seq_ESCs_Human	1.18917591
56	NANOG_19829295_ChIP-Seq_ESCs_Human	1.18917591
57	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.15591970
58	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.15477660
59	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.14867244
60	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.14249609
61	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.13713585
62	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.11796649
63	CBP_20019798_ChIP-Seq_JUKART_Human	1.10872599
64	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.10872599
65	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.09807458
66	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.08955511
67	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.08917619
68	NCOR_22424771_ChIP-Seq_293T_Human	1.08596354
69	AR_20517297_ChIP-Seq_VCAP_Human	1.07447684
70	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.05266588
71	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.05250783
72	DCP1A_22483619_ChIP-Seq_HELA_Human	1.05147196
73	TAF15_26573619_Chip-Seq_HEK293_Human	1.04503562
74	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.04262564
75	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.03886506
76	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.02849028
77	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.99807561
78	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.98302491
79	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.97906954
80	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.94078171
81	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.93705595
82	GATA1_26923725_Chip-Seq_HPCs_Mouse	0.93584705
83	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	0.92543893
84	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.92531771
85	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.91858043
86	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.91344451
87	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.91160679
88	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.90546114
89	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.90407384
90	ERG_20517297_ChIP-Seq_VCAP_Human	0.89733320
91	ER_23166858_ChIP-Seq_MCF-7_Human	0.87908007
92	TCF4_22108803_ChIP-Seq_LS180_Human	0.87590519
93	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.87401347
94	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.87229354
95	TAF2_19829295_ChIP-Seq_ESCs_Human	0.87201351
96	BCAT_22108803_ChIP-Seq_LS180_Human	0.87021041
97	ERA_21632823_ChIP-Seq_H3396_Human	0.86920821
98	GBX2_23144817_ChIP-Seq_PC3_Human	0.85057916
99	HTT_18923047_ChIP-ChIP_STHdh_Human	0.84889647
100	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.84427020

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	5.09699540
2	MP0009379_abnormal_foot_pigmentation	4.85142439
3	MP0002138_abnormal_hepatobiliary_system	3.71077633
4	MP0000569_abnormal_digit_pigmentation	3.07403762
5	MP0003283_abnormal_digestive_organ	2.81819236
6	MP0006292_abnormal_olfactory_placode	2.72317009
7	MP0002938_white_spotting	2.64213633
8	MP0004145_abnormal_muscle_electrophysio	2.57638481
9	MP0002822_catalepsy	2.32838261
10	MP0002837_dystrophic_cardiac_calcinosis	2.28411736
11	MP0004885_abnormal_endolymph	2.28117860
12	MP0001968_abnormal_touch/_nociception	2.25251800
13	MP0002277_abnormal_respiratory_mucosa	2.18890959
14	MP0002102_abnormal_ear_morphology	2.17565044
15	MP0002638_abnormal_pupillary_reflex	2.03629061
16	MP0008995_early_reproductive_senescence	1.95015068
17	MP0005377_hearing/vestibular/ear_phenot	1.90966699
18	MP0003878_abnormal_ear_physiology	1.90966699
19	MP0002234_abnormal_pharynx_morphology	1.88312169
20	MP0003880_abnormal_central_pattern	1.87978780
21	MP0003011_delayed_dark_adaptation	1.80664994
22	MP0005084_abnormal_gallbladder_morpholo	1.80235622
23	MP0001529_abnormal_vocalization	1.79640057
24	MP0006072_abnormal_retinal_apoptosis	1.77566917
25	MP0002736_abnormal_nociception_after	1.65767626
26	MP0002095_abnormal_skin_pigmentation	1.65025713
27	MP0005075_abnormal_melanosome_morpholog	1.57062779
28	MP0004742_abnormal_vestibular_system	1.55587668
29	MP0003121_genomic_imprinting	1.46482787
30	MP0001293_anophthalmia	1.43963281
31	MP0004133_heterotaxia	1.43232344
32	MP0004142_abnormal_muscle_tone	1.42085292
33	MP0001485_abnormal_pinna_reflex	1.40592968
34	MP0003195_calcinosis	1.38815567
35	MP0003890_abnormal_embryonic-extraembry	1.32785397
36	MP0003122_maternal_imprinting	1.32606958
37	MP0003786_premature_aging	1.31841416
38	MP0008058_abnormal_DNA_repair	1.30919355
39	MP0002928_abnormal_bile_duct	1.24245461
40	MP0002282_abnormal_trachea_morphology	1.23324687
41	MP0003186_abnormal_redox_activity	1.17965386
42	MP0003567_abnormal_fetal_cardiomyocyte	1.17195000
43	MP0001905_abnormal_dopamine_level	1.16049377
44	MP0005645_abnormal_hypothalamus_physiol	1.11994525
45	MP0002733_abnormal_thermal_nociception	1.10907420
46	MP0008877_abnormal_DNA_methylation	1.10222771
47	MP0004957_abnormal_blastocyst_morpholog	1.09128994
48	MP0009745_abnormal_behavioral_response	1.08168207
49	MP0008872_abnormal_physiological_respon	1.07662119
50	MP0003693_abnormal_embryo_hatching	1.07236541
51	MP0004381_abnormal_hair_follicle	1.06799865
52	MP0000026_abnormal_inner_ear	1.05931595
53	MP0003787_abnormal_imprinting	1.05739916
54	MP0004147_increased_porphyrin_level	1.05736648
55	MP0002557_abnormal_social/conspecific_i	1.05642011
56	MP0003806_abnormal_nucleotide_metabolis	1.04933867
57	MP0002160_abnormal_reproductive_system	1.04048910
58	MP0005174_abnormal_tail_pigmentation	1.03831682
59	MP0000631_abnormal_neuroendocrine_gland	1.03803865
60	MP0005551_abnormal_eye_electrophysiolog	1.03599716
61	MP0000566_synostosis	1.02655299
62	MP0002067_abnormal_sensory_capabilities	1.02182839
63	MP0008875_abnormal_xenobiotic_pharmacok	1.00870869
64	MP0003937_abnormal_limbs/digits/tail_de	1.00386829
65	MP0000049_abnormal_middle_ear	0.99440029
66	MP0005389_reproductive_system_phenotype	0.98081627
67	MP0003938_abnormal_ear_development	0.97930959
68	MP0002751_abnormal_autonomic_nervous	0.95515618
69	MP0005646_abnormal_pituitary_gland	0.91893605
70	MP0001970_abnormal_pain_threshold	0.90465802
71	MP0001286_abnormal_eye_development	0.87965445
72	MP0001486_abnormal_startle_reflex	0.87286493
73	MP0005253_abnormal_eye_physiology	0.86700764
74	MP0001919_abnormal_reproductive_system	0.86680190
75	MP0002735_abnormal_chemical_nociception	0.84556042
76	MP0005085_abnormal_gallbladder_physiolo	0.83179999
77	MP0000647_abnormal_sebaceous_gland	0.81654276
78	MP0000613_abnormal_salivary_gland	0.81563435
79	MP0003119_abnormal_digestive_system	0.76943253
80	MP0001963_abnormal_hearing_physiology	0.74278819
81	MP0001440_abnormal_grooming_behavior	0.74235319
82	MP0002272_abnormal_nervous_system	0.73403895
83	MP0001881_abnormal_mammary_gland	0.72569959
84	MP0005408_hypopigmentation	0.71297129
85	MP0000778_abnormal_nervous_system	0.70341180
86	MP0005195_abnormal_posterior_eye	0.68919343
87	MP0003315_abnormal_perineum_morphology	0.66284528
88	MP0000372_irregular_coat_pigmentation	0.65027083
89	MP0001984_abnormal_olfaction	0.64976419
90	MP0005671_abnormal_response_to	0.63626119
91	MP0003936_abnormal_reproductive_system	0.63311988
92	MP0002210_abnormal_sex_determination	0.62620008
93	MP0002752_abnormal_somatic_nervous	0.60214002
94	MP0000427_abnormal_hair_cycle	0.59012020
95	MP0001501_abnormal_sleep_pattern	0.58622605
96	MP0004924_abnormal_behavior	0.57088645
97	MP0005386_behavior/neurological_phenoty	0.57088645
98	MP0001727_abnormal_embryo_implantation	0.57087626
99	MP0002734_abnormal_mechanical_nocicepti	0.55345273
100	MP0005220_abnormal_exocrine_pancreas	0.54201498

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.41574807
2	Reticulocytopenia (HP:0001896)	4.41266846
3	Abnormality of cells of the erythroid lineage (HP:0012130)	4.39931656
4	Congenital, generalized hypertrichosis (HP:0004540)	4.16992027
5	Increased hepatocellular lipid droplets (HP:0006565)	4.15934689
6	Abnormal number of erythroid precursors (HP:0012131)	4.14847564
7	Mitochondrial inheritance (HP:0001427)	4.12056252
8	Abnormal mitochondria in muscle tissue (HP:0008316)	3.90348363
9	Acute encephalopathy (HP:0006846)	3.87916485
10	Lipid accumulation in hepatocytes (HP:0006561)	3.78838881
11	Increased CSF lactate (HP:0002490)	3.69049699
12	Pancreatic cysts (HP:0001737)	3.63950123
13	Progressive macrocephaly (HP:0004481)	3.59860034
14	Pancreatic fibrosis (HP:0100732)	3.51937836
15	Hepatic necrosis (HP:0002605)	3.48317692
16	Abnormality of the renal cortex (HP:0011035)	3.38002661
17	Hepatocellular necrosis (HP:0001404)	3.27661114
18	Molar tooth sign on MRI (HP:0002419)	3.24137838
19	Abnormality of midbrain morphology (HP:0002418)	3.24137838
20	Nephronophthisis (HP:0000090)	3.16708057
21	Renal cortical cysts (HP:0000803)	3.12182424
22	Renal Fanconi syndrome (HP:0001994)	3.11615976
23	Generalized aminoaciduria (HP:0002909)	3.02583008
24	Macrocytic anemia (HP:0001972)	3.02378276
25	Exertional dyspnea (HP:0002875)	3.01192447
26	True hermaphroditism (HP:0010459)	2.98715877
27	Degeneration of anterior horn cells (HP:0002398)	2.98471721
28	Abnormality of the anterior horn cell (HP:0006802)	2.98471721
29	Colon cancer (HP:0003003)	2.86022578
30	Abnormality of the renal medulla (HP:0100957)	2.81593700
31	Bilateral microphthalmos (HP:0007633)	2.73193474
32	Increased intramyocellular lipid droplets (HP:0012240)	2.62909906
33	Congenital stationary night blindness (HP:0007642)	2.62130894
34	Optic disc pallor (HP:0000543)	2.61840346
35	Medial flaring of the eyebrow (HP:0010747)	2.61228673
36	Pallor (HP:0000980)	2.50916295
37	Abnormality of renal resorption (HP:0011038)	2.45729788
38	Cerebral edema (HP:0002181)	2.44958650
39	Septo-optic dysplasia (HP:0100842)	2.43704791
40	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.43513488
41	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.40131756
42	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.40131756
43	Retinal dysplasia (HP:0007973)	2.39734900
44	Hypothermia (HP:0002045)	2.38824783
45	Abnormality of the pons (HP:0007361)	2.36349858
46	Type II lissencephaly (HP:0007260)	2.35552222
47	Glycosuria (HP:0003076)	2.34816801
48	Abnormality of urine glucose concentration (HP:0011016)	2.34816801
49	Respiratory failure (HP:0002878)	2.30691612
50	Hypoplasia of the pons (HP:0012110)	2.30625411
51	3-Methylglutaconic aciduria (HP:0003535)	2.29226165
52	Tubulointerstitial fibrosis (HP:0005576)	2.14741698
53	Tubular atrophy (HP:0000092)	2.14322489
54	Leukodystrophy (HP:0002415)	2.13226829
55	Postaxial foot polydactyly (HP:0001830)	2.10473015
56	Tongue fasciculations (HP:0001308)	2.10041291
57	Increased muscle lipid content (HP:0009058)	2.08582544
58	Absent thumb (HP:0009777)	2.08556697
59	Congenital hepatic fibrosis (HP:0002612)	2.07707728
60	Limb dystonia (HP:0002451)	2.06244429
61	Supernumerary spleens (HP:0009799)	2.05790208
62	Hyperglycinuria (HP:0003108)	2.05718684
63	Lactic acidosis (HP:0003128)	2.04950602
64	Abnormal respiratory epithelium morphology (HP:0012253)	2.04923379
65	Abnormal respiratory motile cilium morphology (HP:0005938)	2.04923379
66	Cystic liver disease (HP:0006706)	2.03582572
67	Anencephaly (HP:0002323)	2.00834946
68	Short tibia (HP:0005736)	1.97793183
69	Abnormal drinking behavior (HP:0030082)	1.96938339
70	Polydipsia (HP:0001959)	1.96938339
71	Concave nail (HP:0001598)	1.96039572
72	Bile duct proliferation (HP:0001408)	1.94052084
73	Abnormal biliary tract physiology (HP:0012439)	1.94052084
74	Abolished electroretinogram (ERG) (HP:0000550)	1.93155293
75	Amelogenesis imperfecta (HP:0000705)	1.90953394
76	Hyperglycinemia (HP:0002154)	1.90797347
77	Sclerocornea (HP:0000647)	1.90192564
78	Maternal diabetes (HP:0009800)	1.89305675
79	Increased serum lactate (HP:0002151)	1.87318145
80	Constricted visual fields (HP:0001133)	1.86212508
81	Exercise intolerance (HP:0003546)	1.85587969
82	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.81075443
83	Abnormal respiratory motile cilium physiology (HP:0012261)	1.80391440
84	Anophthalmia (HP:0000528)	1.79701520
85	Respiratory difficulties (HP:0002880)	1.79593551
86	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.79060276
87	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.79002609
88	Hypochromic microcytic anemia (HP:0004840)	1.78889710
89	Reduced antithrombin III activity (HP:0001976)	1.78535419
90	Woolly hair (HP:0002224)	1.77520275
91	Type I transferrin isoform profile (HP:0003642)	1.76839846
92	Panhypogammaglobulinemia (HP:0003139)	1.75983285
93	Absent septum pellucidum (HP:0001331)	1.75749333
94	Rhinitis (HP:0012384)	1.74282032
95	Ulnar claw (HP:0001178)	1.73961749
96	Hyperphosphaturia (HP:0003109)	1.72422686
97	Lethargy (HP:0001254)	1.72120129
98	Severe combined immunodeficiency (HP:0004430)	1.71968033
99	Bifid tongue (HP:0010297)	1.69501128
100	Postaxial hand polydactyly (HP:0001162)	1.69260398

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	5.01426014
2	BMPR1B	4.48426690
3	CDK8	3.25884594
4	VRK1	3.24228799
5	NUAK1	3.14979261
6	TGFBR1	3.08448552
7	STK16	2.83950545
8	TAF1	2.70890757
9	CDK19	2.45358991
10	GRK1	2.05511336
11	NME1	2.03929052
12	TAOK3	2.03241950
13	ADRBK2	1.96604276
14	WNK3	1.83402446
15	TLK1	1.78286381
16	TXK	1.66334129
17	PASK	1.65740892
18	ZAK	1.64326198
19	MAPK15	1.61512827
20	PLK3	1.58608386
21	EPHA4	1.54826752
22	DYRK2	1.43247635
23	PNCK	1.30797127
24	FRK	1.29241538
25	CAMKK2	1.24164972
26	BUB1	1.22511559
27	EPHB2	1.15172657
28	TSSK6	1.09902442
29	BLK	1.07313183
30	TIE1	1.07112315
31	DAPK3	0.97151681
32	RPS6KA4	0.96341299
33	TEC	0.94968623
34	CDC7	0.93636745
35	EIF2AK3	0.91188940
36	CDK3	0.91052734
37	PLK4	0.89872491
38	NEK2	0.88605462
39	WEE1	0.88220488
40	PRKCG	0.85969930
41	MKNK1	0.85562360
42	NME2	0.85037601
43	WNK4	0.83526592
44	CDK9	0.81342860
45	EIF2AK2	0.81342735
46	MAP4K2	0.78390368
47	MKNK2	0.77748077
48	CASK	0.70942389
49	CHEK2	0.70535616
50	ADRBK1	0.68942979
51	DYRK3	0.68756693
52	MAPKAPK5	0.68672097
53	INSRR	0.68543180
54	CSNK1G1	0.68375067
55	PHKG1	0.67825250
56	PHKG2	0.67825250
57	SRPK1	0.67590392
58	MAP4K1	0.66501216
59	PLK2	0.66371636
60	GRK7	0.64827403
61	STK38L	0.64146400
62	OXSR1	0.64015656
63	PRKCE	0.63567045
64	DYRK1A	0.63119046
65	GRK5	0.63038779
66	BRSK2	0.60508126
67	ILK	0.56608291
68	CAMK1	0.53216996
69	SYK	0.52891368
70	BCKDK	0.52087078
71	GRK6	0.51583984
72	CSNK1A1	0.51036993
73	PINK1	0.50866281
74	CSNK1G2	0.50525329
75	CDK7	0.49632989
76	CSNK1G3	0.49272593
77	CSNK2A2	0.47906041
78	CHUK	0.47635456
79	ITK	0.47118767
80	IKBKB	0.46154627
81	ATR	0.45583629
82	NEK1	0.44635511
83	LRRK2	0.43869048
84	PIK3CA	0.43609797
85	MAPK13	0.43220063
86	PTK2B	0.42799620
87	FGFR2	0.42643059
88	KIT	0.42573688
89	PRKACA	0.41363107
90	AURKB	0.39542576
91	OBSCN	0.38417955
92	CSNK2A1	0.37929795
93	TNIK	0.34514584
94	PKN1	0.33822204
95	RPS6KA5	0.32471947
96	SMG1	0.31871446
97	ERBB2	0.30231220
98	CSNK1E	0.29691845
99	TTK	0.28698847
100	IRAK1	0.28364739

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.97479273
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.80504921
3	Parkinsons disease_Homo sapiens_hsa05012	3.79224296
4	Proteasome_Homo sapiens_hsa03050	2.94241068
5	Huntingtons disease_Homo sapiens_hsa05016	2.67046110
6	Alzheimers disease_Homo sapiens_hsa05010	2.66782499
7	Protein export_Homo sapiens_hsa03060	2.56997632
8	Asthma_Homo sapiens_hsa05310	2.44905885
9	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.32622788
10	Cardiac muscle contraction_Homo sapiens_hsa04260	2.23992487
11	Homologous recombination_Homo sapiens_hsa03440	2.21848750
12	Nitrogen metabolism_Homo sapiens_hsa00910	2.07345794
13	Mismatch repair_Homo sapiens_hsa03430	1.85470978
14	RNA polymerase_Homo sapiens_hsa03020	1.81168034
15	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.62433892
16	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.53843481
17	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.52167733
18	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.52066388
19	Allograft rejection_Homo sapiens_hsa05330	1.50688499
20	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.47596169
21	Type I diabetes mellitus_Homo sapiens_hsa04940	1.45462201
22	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.43895885
23	Graft-versus-host disease_Homo sapiens_hsa05332	1.43249275
24	Linoleic acid metabolism_Homo sapiens_hsa00591	1.41166675
25	Nucleotide excision repair_Homo sapiens_hsa03420	1.39008301
26	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.35527290
27	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.33737536
28	Basal transcription factors_Homo sapiens_hsa03022	1.31555832
29	RNA degradation_Homo sapiens_hsa03018	1.24648477
30	One carbon pool by folate_Homo sapiens_hsa00670	1.20590853
31	DNA replication_Homo sapiens_hsa03030	1.15813218
32	Fanconi anemia pathway_Homo sapiens_hsa03460	1.14962079
33	Spliceosome_Homo sapiens_hsa03040	1.09273487
34	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.06510311
35	Folate biosynthesis_Homo sapiens_hsa00790	1.05767317
36	RNA transport_Homo sapiens_hsa03013	1.02157564
37	Purine metabolism_Homo sapiens_hsa00230	1.01632790
38	Phototransduction_Homo sapiens_hsa04744	0.99586533
39	Collecting duct acid secretion_Homo sapiens_hsa04966	0.98871470
40	Rheumatoid arthritis_Homo sapiens_hsa05323	0.98857425
41	Pyrimidine metabolism_Homo sapiens_hsa00240	0.97471903
42	Tryptophan metabolism_Homo sapiens_hsa00380	0.95098262
43	Base excision repair_Homo sapiens_hsa03410	0.94376423
44	Primary immunodeficiency_Homo sapiens_hsa05340	0.92486780
45	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.88786415
46	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.87944307
47	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.84976522
48	Butanoate metabolism_Homo sapiens_hsa00650	0.83628328
49	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.82774261
50	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.78772884
51	Ether lipid metabolism_Homo sapiens_hsa00565	0.78477067
52	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.78156071
53	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.77305868
54	Propanoate metabolism_Homo sapiens_hsa00640	0.75351416
55	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.74843550
56	Pyruvate metabolism_Homo sapiens_hsa00620	0.74477248
57	Sulfur relay system_Homo sapiens_hsa04122	0.73816685
58	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.73219350
59	Antigen processing and presentation_Homo sapiens_hsa04612	0.70410822
60	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.68358920
61	Fat digestion and absorption_Homo sapiens_hsa04975	0.67949703
62	Metabolic pathways_Homo sapiens_hsa01100	0.66357622
63	Peroxisome_Homo sapiens_hsa04146	0.64881070
64	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.52178343
65	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.51872712
66	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.51052916
67	Olfactory transduction_Homo sapiens_hsa04740	0.46869763
68	Caffeine metabolism_Homo sapiens_hsa00232	0.46089433
69	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.45372678
70	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.45323214
71	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.43488164
72	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.43478240
73	Fatty acid degradation_Homo sapiens_hsa00071	0.43210400
74	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.43003599
75	Basal cell carcinoma_Homo sapiens_hsa05217	0.42142056
76	Chemical carcinogenesis_Homo sapiens_hsa05204	0.41958302
77	Retinol metabolism_Homo sapiens_hsa00830	0.41626045
78	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.40538127
79	Histidine metabolism_Homo sapiens_hsa00340	0.39557154
80	Nicotine addiction_Homo sapiens_hsa05033	0.37044082
81	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.34018605
82	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.33581928
83	Tyrosine metabolism_Homo sapiens_hsa00350	0.33491415
84	p53 signaling pathway_Homo sapiens_hsa04115	0.33201536
85	Non-homologous end-joining_Homo sapiens_hsa03450	0.30851269
86	Taste transduction_Homo sapiens_hsa04742	0.30834684
87	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.29505960
88	Regulation of autophagy_Homo sapiens_hsa04140	0.28855659
89	Morphine addiction_Homo sapiens_hsa05032	0.28505018
90	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.28417521
91	Arginine and proline metabolism_Homo sapiens_hsa00330	0.27701327
92	Serotonergic synapse_Homo sapiens_hsa04726	0.23370815
93	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.20885782
94	Sulfur metabolism_Homo sapiens_hsa00920	0.19055835
95	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.18647914
96	beta-Alanine metabolism_Homo sapiens_hsa00410	0.17523980
97	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.16135473
98	Glycerolipid metabolism_Homo sapiens_hsa00561	0.15543921
99	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.14255946
100	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.13415469

NACAP2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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