ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit biogenesis (GO:0042274)	6.83143569
2	ribosomal small subunit assembly (GO:0000028)	6.47602566
3	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.08897168
4	ATP synthesis coupled proton transport (GO:0015986)	6.08897168
5	viral transcription (GO:0019083)	5.88290064
6	translational termination (GO:0006415)	5.61524184
7	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.59395686
8	maturation of SSU-rRNA (GO:0030490)	5.52607966
9	GTP biosynthetic process (GO:0006183)	5.29843912
10	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	5.14307844
11	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	5.12006224
12	chaperone-mediated protein transport (GO:0072321)	5.07229838
13	translational elongation (GO:0006414)	4.91840036
14	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.89055267
15	cotranslational protein targeting to membrane (GO:0006613)	4.86534178
16	respiratory electron transport chain (GO:0022904)	4.86423655
17	DNA deamination (GO:0045006)	4.82849365
18	protein targeting to ER (GO:0045047)	4.80432806
19	electron transport chain (GO:0022900)	4.78726580
20	protein complex biogenesis (GO:0070271)	4.65561379
21	UTP biosynthetic process (GO:0006228)	4.64441468
22	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.60359352
23	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.60359352
24	NADH dehydrogenase complex assembly (GO:0010257)	4.60359352
25	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.59983796
26	protein localization to endoplasmic reticulum (GO:0070972)	4.52631120
27	protein neddylation (GO:0045116)	4.46532057
28	UTP metabolic process (GO:0046051)	4.40180617
29	mitochondrial respiratory chain complex assembly (GO:0033108)	4.36972535
30	pyrimidine nucleotide catabolic process (GO:0006244)	4.29485428
31	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.25318464
32	respiratory chain complex IV assembly (GO:0008535)	4.23549473
33	cellular protein complex disassembly (GO:0043624)	4.22952023
34	behavioral response to nicotine (GO:0035095)	4.21858862
35	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	4.14567776
36	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	4.13054534
37	peptidyl-histidine modification (GO:0018202)	4.10987146
38	translational initiation (GO:0006413)	4.09927748
39	viral life cycle (GO:0019058)	4.08469686
40	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.07442024
41	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	4.05442453
42	purine nucleoside triphosphate biosynthetic process (GO:0009145)	4.03052617
43	CTP biosynthetic process (GO:0006241)	3.99758649
44	CTP metabolic process (GO:0046036)	3.99758649
45	guanosine-containing compound biosynthetic process (GO:1901070)	3.96569422
46	translation (GO:0006412)	3.96128717
47	cytochrome complex assembly (GO:0017004)	3.93546053
48	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	3.89847699
49	water-soluble vitamin biosynthetic process (GO:0042364)	3.88158594
50	protein polyglutamylation (GO:0018095)	3.81564170
51	ATP biosynthetic process (GO:0006754)	3.76173677
52	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.73705945
53	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.73705945
54	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.70894802
55	pseudouridine synthesis (GO:0001522)	3.70765468
56	maturation of 5.8S rRNA (GO:0000460)	3.69061634
57	protein targeting to mitochondrion (GO:0006626)	3.67936824
58	ribosomal large subunit biogenesis (GO:0042273)	3.60527958
59	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	3.59750510
60	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.59051427
61	termination of RNA polymerase III transcription (GO:0006386)	3.59051427
62	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.57714203
63	protein-cofactor linkage (GO:0018065)	3.52309037
64	cellular component biogenesis (GO:0044085)	3.51768972
65	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.48119647
66	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	3.47384144
67	protein complex disassembly (GO:0043241)	3.43781128
68	hydrogen ion transmembrane transport (GO:1902600)	3.43485638
69	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.40225860
70	ribonucleoprotein complex biogenesis (GO:0022613)	3.36268779
71	rRNA processing (GO:0006364)	3.34591920
72	establishment of protein localization to mitochondrion (GO:0072655)	3.34043684
73	base-excision repair, AP site formation (GO:0006285)	3.31680717
74	macromolecular complex disassembly (GO:0032984)	3.30965760
75	nucleoside triphosphate biosynthetic process (GO:0009142)	3.30654690
76	response to pheromone (GO:0019236)	3.29515719
77	nucleoside diphosphate phosphorylation (GO:0006165)	3.28884743
78	heart contraction (GO:0060047)	3.24569358
79	heart process (GO:0003015)	3.24569358
80	rRNA metabolic process (GO:0016072)	3.22793433
81	deoxyribonucleotide catabolic process (GO:0009264)	3.15750403
82	proton transport (GO:0015992)	3.12763351
83	regulation of mitochondrial translation (GO:0070129)	3.10061358
84	protein localization to mitochondrion (GO:0070585)	3.08649072
85	hydrogen transport (GO:0006818)	3.05617534
86	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.03618107
87	protein targeting to membrane (GO:0006612)	3.02293465
88	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.01997339
89	regulation of cellular respiration (GO:0043457)	3.00177510
90	deoxyribose phosphate catabolic process (GO:0046386)	2.98462616
91	negative regulation of telomere maintenance (GO:0032205)	2.92676811
92	proteasome assembly (GO:0043248)	2.86579648
93	pyrimidine nucleotide biosynthetic process (GO:0006221)	2.85213711
94	mRNA catabolic process (GO:0006402)	2.82291203
95	cytidine deamination (GO:0009972)	2.75204759
96	cytidine metabolic process (GO:0046087)	2.75204759
97	cytidine catabolic process (GO:0006216)	2.75204759
98	metallo-sulfur cluster assembly (GO:0031163)	2.73128992
99	iron-sulfur cluster assembly (GO:0016226)	2.73128992
100	pyrimidine ribonucleoside biosynthetic process (GO:0046132)	2.72765969

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.67002930
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.23348815
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.83417561
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.75778890
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.61092609
6	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.40327970
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.21365862
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.08434203
9	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.05495697
10	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.64863448
11	EZH2_22144423_ChIP-Seq_EOC_Human	2.53442419
12	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.47448193
13	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.35064890
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.29064187
15	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.12081104
16	VDR_22108803_ChIP-Seq_LS180_Human	2.10316557
17	ZNF274_21170338_ChIP-Seq_K562_Hela	2.01226172
18	FOXP3_21729870_ChIP-Seq_TREG_Human	1.99641239
19	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.97026867
20	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.90799034
21	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.86642654
22	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.84899116
23	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.76802975
24	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.73352579
25	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.66991927
26	GABP_19822575_ChIP-Seq_HepG2_Human	1.65703326
27	MYC_18940864_ChIP-ChIP_HL60_Human	1.62471307
28	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.61393396
29	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.61106303
30	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.59108676
31	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.58471468
32	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.57794817
33	TTF2_22483619_ChIP-Seq_HELA_Human	1.57326385
34	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.55120703
35	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.53765506
36	IGF1R_20145208_ChIP-Seq_DFB_Human	1.53147549
37	NCOR_22424771_ChIP-Seq_293T_Human	1.52504244
38	NANOG_20526341_ChIP-Seq_ESCs_Human	1.50402853
39	TP53_22573176_ChIP-Seq_HFKS_Human	1.50100328
40	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.48579747
41	XRN2_22483619_ChIP-Seq_HELA_Human	1.47915999
42	FUS_26573619_Chip-Seq_HEK293_Human	1.36988474
43	ELK1_19687146_ChIP-ChIP_HELA_Human	1.36767342
44	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.34078184
45	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.33026665
46	EWS_26573619_Chip-Seq_HEK293_Human	1.32712838
47	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.28183093
48	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.27802602
49	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.27103089
50	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.25145387
51	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.24700159
52	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.24389698
53	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.21858455
54	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.20672161
55	TAF2_19829295_ChIP-Seq_ESCs_Human	1.16574657
56	STAT1_20625510_ChIP-Seq_HELA_Human	1.14558155
57	IRF1_19129219_ChIP-ChIP_H3396_Human	1.14437619
58	AR_20517297_ChIP-Seq_VCAP_Human	1.14299814
59	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.13566892
60	MYC_19829295_ChIP-Seq_ESCs_Human	1.13333251
61	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.12637883
62	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.11988524
63	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.10464221
64	P53_21459846_ChIP-Seq_SAOS-2_Human	1.10251373
65	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.09356352
66	DCP1A_22483619_ChIP-Seq_HELA_Human	1.09347021
67	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.08728309
68	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.07183208
69	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.05951463
70	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.05817846
71	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.04887655
72	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.04523633
73	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.02842149
74	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.02271129
75	ERA_21632823_ChIP-Seq_H3396_Human	1.02133518
76	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.01251926
77	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.00666187
78	CTCF_20526341_ChIP-Seq_ESCs_Human	0.99751496
79	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.98853256
80	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.98358769
81	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.98261147
82	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.98189521
83	RNF2_27304074_Chip-Seq_NSC_Mouse	0.97261960
84	CIITA_25753668_ChIP-Seq_RAJI_Human	0.96885032
85	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.95973662
86	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.95854079
87	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.94645768
88	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.94204241
89	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.94082645
90	NANOG_19829295_ChIP-Seq_ESCs_Human	0.92703695
91	SOX2_19829295_ChIP-Seq_ESCs_Human	0.92703695
92	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.91350096
93	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.90857932
94	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.89623979
95	HTT_18923047_ChIP-ChIP_STHdh_Human	0.89431056
96	ERG_20517297_ChIP-Seq_VCAP_Human	0.89206727
97	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.89142571
98	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.88087242
99	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.87380295
100	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.87333595

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	4.57661843
2	MP0009379_abnormal_foot_pigmentation	4.01572477
3	MP0003123_paternal_imprinting	3.54654818
4	MP0003122_maternal_imprinting	3.33299947
5	MP0005646_abnormal_pituitary_gland	3.23912570
6	MP0002837_dystrophic_cardiac_calcinosis	2.84806134
7	MP0002163_abnormal_gland_morphology	2.77952309
8	MP0003787_abnormal_imprinting	2.75939834
9	MP0003121_genomic_imprinting	2.71791464
10	MP0005379_endocrine/exocrine_gland_phen	2.44318807
11	MP0004142_abnormal_muscle_tone	2.43517728
12	MP0008875_abnormal_xenobiotic_pharmacok	2.32305071
13	MP0002638_abnormal_pupillary_reflex	2.20460447
14	MP0000372_irregular_coat_pigmentation	2.00663078
15	MP0002938_white_spotting	1.96242994
16	MP0004145_abnormal_muscle_electrophysio	1.87146050
17	MP0003283_abnormal_digestive_organ	1.84937819
18	MP0001968_abnormal_touch/_nociception	1.80880336
19	MP0009046_muscle_twitch	1.80466757
20	MP0005551_abnormal_eye_electrophysiolog	1.65153928
21	MP0005084_abnormal_gallbladder_morpholo	1.59475150
22	MP0006276_abnormal_autonomic_nervous	1.57922362
23	MP0004885_abnormal_endolymph	1.54702905
24	MP0000631_abnormal_neuroendocrine_gland	1.54135964
25	MP0002160_abnormal_reproductive_system	1.49339844
26	MP0002138_abnormal_hepatobiliary_system	1.44806654
27	MP0003186_abnormal_redox_activity	1.44168453
28	MP0003195_calcinosis	1.43213927
29	MP0006036_abnormal_mitochondrial_physio	1.42484274
30	MP0002653_abnormal_ependyma_morphology	1.42358899
31	MP0004147_increased_porphyrin_level	1.42353904
32	MP0008877_abnormal_DNA_methylation	1.41857038
33	MP0009745_abnormal_behavioral_response	1.39882844
34	MP0008789_abnormal_olfactory_epithelium	1.38211101
35	MP0002876_abnormal_thyroid_physiology	1.37384979
36	MP0005174_abnormal_tail_pigmentation	1.35397680
37	MP0001188_hyperpigmentation	1.35108534
38	MP0002272_abnormal_nervous_system	1.34446802
39	MP0000678_abnormal_parathyroid_gland	1.33935470
40	MP0000049_abnormal_middle_ear	1.33438286
41	MP0001905_abnormal_dopamine_level	1.32324812
42	MP0002736_abnormal_nociception_after	1.31075628
43	MP0008872_abnormal_physiological_respon	1.29846311
44	MP0005671_abnormal_response_to	1.27779857
45	MP0005389_reproductive_system_phenotype	1.25229186
46	MP0005670_abnormal_white_adipose	1.23590777
47	MP0005377_hearing/vestibular/ear_phenot	1.20813491
48	MP0003878_abnormal_ear_physiology	1.20813491
49	MP0002102_abnormal_ear_morphology	1.16966669
50	MP0005645_abnormal_hypothalamus_physiol	1.13061889
51	MP0002733_abnormal_thermal_nociception	1.11937945
52	MP0002557_abnormal_social/conspecific_i	1.10829471
53	MP0001986_abnormal_taste_sensitivity	1.07444913
54	MP0001970_abnormal_pain_threshold	1.06224803
55	MP0001764_abnormal_homeostasis	1.05560979
56	MP0006072_abnormal_retinal_apoptosis	1.05102597
57	MP0005332_abnormal_amino_acid	1.01395398
58	MP0003567_abnormal_fetal_cardiomyocyte	1.00261754
59	MP0008058_abnormal_DNA_repair	0.99053201
60	MP0003880_abnormal_central_pattern	0.96364368
61	MP0005499_abnormal_olfactory_system	0.95917117
62	MP0005394_taste/olfaction_phenotype	0.95917117
63	MP0005636_abnormal_mineral_homeostasis	0.95883679
64	MP0004742_abnormal_vestibular_system	0.95826037
65	MP0002095_abnormal_skin_pigmentation	0.94296742
66	MP0003786_premature_aging	0.93624231
67	MP0003011_delayed_dark_adaptation	0.93053665
68	MP0001919_abnormal_reproductive_system	0.91912781
69	MP0003693_abnormal_embryo_hatching	0.91791916
70	MP0001270_distended_abdomen	0.88829534
71	MP0001293_anophthalmia	0.88129288
72	MP0002184_abnormal_innervation	0.88020739
73	MP0005075_abnormal_melanosome_morpholog	0.86858882
74	MP0000015_abnormal_ear_pigmentation	0.84702258
75	MP0003646_muscle_fatigue	0.83916767
76	MP0005253_abnormal_eye_physiology	0.79959731
77	MP0002064_seizures	0.79352110
78	MP0000681_abnormal_thyroid_gland	0.79170957
79	MP0000516_abnormal_urinary_system	0.78833647
80	MP0005367_renal/urinary_system_phenotyp	0.78833647
81	MP0005195_abnormal_posterior_eye	0.76794258
82	MP0005503_abnormal_tendon_morphology	0.76144303
83	MP0003136_yellow_coat_color	0.75764006
84	MP0001324_abnormal_eye_pigmentation	0.73010676
85	MP0000026_abnormal_inner_ear	0.72823990
86	MP0002210_abnormal_sex_determination	0.70947306
87	MP0002822_catalepsy	0.69709672
88	MP0001440_abnormal_grooming_behavior	0.69708918
89	MP0000427_abnormal_hair_cycle	0.69491674
90	MP0002734_abnormal_mechanical_nocicepti	0.67178562
91	MP0003806_abnormal_nucleotide_metabolis	0.66797025
92	MP0001765_abnormal_ion_homeostasis	0.66655575
93	MP0003315_abnormal_perineum_morphology	0.65745270
94	MP0002067_abnormal_sensory_capabilities	0.64145691
95	MP0001963_abnormal_hearing_physiology	0.63564070
96	MP0002572_abnormal_emotion/affect_behav	0.62607692
97	MP0002752_abnormal_somatic_nervous	0.62409028
98	MP0001529_abnormal_vocalization	0.60673860
99	MP0001756_abnormal_urination	0.60476116
100	MP0001485_abnormal_pinna_reflex	0.60398182

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.93782026
2	Abnormal mitochondria in muscle tissue (HP:0008316)	4.41032580
3	Mitochondrial inheritance (HP:0001427)	4.32044389
4	Progressive macrocephaly (HP:0004481)	4.22101800
5	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	4.15850438
6	Decreased activity of mitochondrial respiratory chain (HP:0008972)	4.15850438
7	Renal Fanconi syndrome (HP:0001994)	4.12538545
8	Acute encephalopathy (HP:0006846)	4.09651822
9	3-Methylglutaconic aciduria (HP:0003535)	4.00786367
10	Increased CSF lactate (HP:0002490)	3.99944157
11	Increased hepatocellular lipid droplets (HP:0006565)	3.86577756
12	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.50757508
13	Cerebral edema (HP:0002181)	3.41691768
14	Lipid accumulation in hepatocytes (HP:0006561)	3.38939920
15	Abnormal rod and cone electroretinograms (HP:0008323)	3.36877150
16	Pancreatic fibrosis (HP:0100732)	3.34055954
17	Congenital stationary night blindness (HP:0007642)	3.20717341
18	Hepatic necrosis (HP:0002605)	3.06593843
19	Hepatocellular necrosis (HP:0001404)	3.06259856
20	Pancreatic cysts (HP:0001737)	3.04738399
21	Optic disc pallor (HP:0000543)	3.02425440
22	Abnormality of cells of the erythroid lineage (HP:0012130)	3.01776368
23	Abnormality of midbrain morphology (HP:0002418)	2.98716753
24	Molar tooth sign on MRI (HP:0002419)	2.98716753
25	Increased intramyocellular lipid droplets (HP:0012240)	2.95397174
26	Reduced antithrombin III activity (HP:0001976)	2.93230359
27	Abnormal number of erythroid precursors (HP:0012131)	2.90734167
28	Exertional dyspnea (HP:0002875)	2.87740461
29	Abnormal drinking behavior (HP:0030082)	2.82418599
30	Polydipsia (HP:0001959)	2.82418599
31	Macrocytic anemia (HP:0001972)	2.80782776
32	Microretrognathia (HP:0000308)	2.69521957
33	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.65064696
34	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.61276507
35	Glycosuria (HP:0003076)	2.59382099
36	Abnormality of urine glucose concentration (HP:0011016)	2.59382099
37	Lactic acidosis (HP:0003128)	2.59196946
38	Testicular atrophy (HP:0000029)	2.50815309
39	Abnormality of renal resorption (HP:0011038)	2.48122591
40	True hermaphroditism (HP:0010459)	2.46252167
41	Increased serum lactate (HP:0002151)	2.45665346
42	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.45435500
43	Absent/shortened dynein arms (HP:0200106)	2.45435500
44	Respiratory difficulties (HP:0002880)	2.37188472
45	Increased muscle lipid content (HP:0009058)	2.37073497
46	Respiratory failure (HP:0002878)	2.31233510
47	Decreased central vision (HP:0007663)	2.30325993
48	Lethargy (HP:0001254)	2.28793807
49	Abnormality of the renal cortex (HP:0011035)	2.26712028
50	Exercise intolerance (HP:0003546)	2.25128236
51	Concave nail (HP:0001598)	2.24870313
52	Cerebral hypomyelination (HP:0006808)	2.23711992
53	Elevated erythrocyte sedimentation rate (HP:0003565)	2.22983102
54	Medial flaring of the eyebrow (HP:0010747)	2.22582767
55	Constricted visual fields (HP:0001133)	2.19873342
56	Hyperphosphaturia (HP:0003109)	2.19410125
57	Polyuria (HP:0000103)	2.18912569
58	Abolished electroretinogram (ERG) (HP:0000550)	2.17690065
59	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.16569426
60	Leukodystrophy (HP:0002415)	2.15766567
61	Absent thumb (HP:0009777)	2.14560404
62	Reticulocytopenia (HP:0001896)	2.13640885
63	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.08601700
64	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.07827287
65	Abnormal protein N-linked glycosylation (HP:0012347)	2.07827287
66	Abnormal protein glycosylation (HP:0012346)	2.07827287
67	Abnormal glycosylation (HP:0012345)	2.07827287
68	Nephronophthisis (HP:0000090)	2.07701499
69	Asplenia (HP:0001746)	2.07572620
70	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.06100850
71	Generalized aminoaciduria (HP:0002909)	2.03470152
72	Abnormality of the renal medulla (HP:0100957)	1.98190045
73	Chronic bronchitis (HP:0004469)	1.97613422
74	Hypoplasia of the uterus (HP:0000013)	1.96251052
75	Abnormality of magnesium homeostasis (HP:0004921)	1.93944213
76	Macular degeneration (HP:0000608)	1.93067314
77	Cystic liver disease (HP:0006706)	1.91668275
78	Triphalangeal thumb (HP:0001199)	1.90769743
79	Myokymia (HP:0002411)	1.90439193
80	Pendular nystagmus (HP:0012043)	1.87511164
81	Aplasia/hypoplasia of the uterus (HP:0008684)	1.86222150
82	Abnormal respiratory motile cilium physiology (HP:0012261)	1.83712236
83	Pallor (HP:0000980)	1.83057685
84	Sclerocornea (HP:0000647)	1.82750619
85	CNS demyelination (HP:0007305)	1.81024814
86	Abnormal respiratory motile cilium morphology (HP:0005938)	1.80964706
87	Abnormal respiratory epithelium morphology (HP:0012253)	1.80964706
88	Adrenal hypoplasia (HP:0000835)	1.80113513
89	Abnormal urine output (HP:0012590)	1.78377123
90	Rib fusion (HP:0000902)	1.76854935
91	Progressive microcephaly (HP:0000253)	1.76850874
92	Type I transferrin isoform profile (HP:0003642)	1.76684720
93	Parakeratosis (HP:0001036)	1.76211649
94	Oligomenorrhea (HP:0000876)	1.75795117
95	Anencephaly (HP:0002323)	1.75549162
96	Type II lissencephaly (HP:0007260)	1.74870519
97	Ketosis (HP:0001946)	1.73232648
98	Hypophosphatemic rickets (HP:0004912)	1.71747920
99	Pachygyria (HP:0001302)	1.70769462
100	Colon cancer (HP:0003003)	1.68374869

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NME2	4.03959563
2	STK16	3.85995085
3	ZAK	3.54023706
4	TLK1	3.07362115
5	BCKDK	2.93636509
6	VRK2	2.63395949
7	WNK4	2.54977298
8	FRK	2.47592887
9	BMPR1B	2.32236568
10	MUSK	2.28894510
11	NUAK1	2.24618930
12	GRK1	2.18185964
13	BRSK2	1.81202481
14	WNK3	1.72026895
15	TNIK	1.70679205
16	ADRBK2	1.64537895
17	DAPK2	1.64363640
18	MAP2K7	1.63066045
19	MAP3K13	1.61241276
20	TAOK3	1.38208925
21	DYRK2	1.35530378
22	CSNK1G3	1.34259952
23	BUB1	1.25259525
24	PINK1	1.24989508
25	KDR	1.19585660
26	LIMK1	1.19360742
27	WEE1	1.19151584
28	CAMKK2	1.14768833
29	VRK1	1.12012014
30	CSNK1G2	1.08792760
31	STK39	1.02863554
32	TIE1	0.99963560
33	PDK2	0.98767830
34	IKBKB	0.98086530
35	CSNK1A1L	0.97734518
36	PASK	0.96703214
37	BRSK1	0.96632627
38	LRRK2	0.87450300
39	PRKCG	0.87052005
40	CSNK1G1	0.86657973
41	TXK	0.84360729
42	HIPK2	0.81582861
43	MAP4K2	0.81044017
44	ABL2	0.79033523
45	TNK2	0.77191014
46	PIM2	0.76997453
47	OXSR1	0.75755579
48	PHKG2	0.74523237
49	PHKG1	0.74523237
50	PAK3	0.72579635
51	DYRK3	0.72016676
52	CSNK2A2	0.71092414
53	AURKA	0.70432317
54	ATR	0.69845334
55	BTK	0.69758806
56	INSRR	0.68171789
57	MAPKAPK5	0.67793458
58	TEC	0.67762723
59	MINK1	0.66098231
60	BRAF	0.65672118
61	PLK1	0.65671970
62	ILK	0.65205068
63	PRKCQ	0.64550877
64	PLK2	0.64499349
65	RPS6KA5	0.64303406
66	PLK4	0.63529537
67	STK3	0.63303160
68	DAPK1	0.62426866
69	CSNK2A1	0.60344989
70	ADRBK1	0.59022346
71	SYK	0.56407742
72	ARAF	0.55750594
73	CSNK1A1	0.53767990
74	PRKACA	0.52520795
75	MARK1	0.51706234
76	EIF2AK1	0.50775743
77	RPS6KA6	0.50260902
78	MAPK13	0.49995759
79	PRKCE	0.49777956
80	PRKCI	0.49549837
81	PIM1	0.48233588
82	CAMKK1	0.47786795
83	PRKCA	0.47668738
84	ITK	0.46949967
85	IKBKE	0.46867039
86	OBSCN	0.46843790
87	CHEK2	0.46324978
88	DAPK3	0.45793924
89	TRIM28	0.43752894
90	MKNK2	0.43286309
91	CASK	0.43285009
92	PRKG2	0.42143102
93	PRKCD	0.40806141
94	STK24	0.40600506
95	PRKG1	0.38599165
96	GRK5	0.38406139
97	PAK1	0.38232720
98	MAP3K4	0.37083899
99	DYRK1A	0.36567552
100	PRKCH	0.35702595

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.55835215
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.87782633
3	Parkinsons disease_Homo sapiens_hsa05012	3.96817384
4	Huntingtons disease_Homo sapiens_hsa05016	2.86584433
5	Alzheimers disease_Homo sapiens_hsa05010	2.78490681
6	RNA polymerase_Homo sapiens_hsa03020	2.67045135
7	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.57763855
8	Proteasome_Homo sapiens_hsa03050	2.39871058
9	Cardiac muscle contraction_Homo sapiens_hsa04260	2.28920464
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.19613007
11	Asthma_Homo sapiens_hsa05310	2.07999274
12	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.00527339
13	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.89352744
14	Linoleic acid metabolism_Homo sapiens_hsa00591	1.83113544
15	Pyrimidine metabolism_Homo sapiens_hsa00240	1.71242804
16	Protein export_Homo sapiens_hsa03060	1.67364771
17	Homologous recombination_Homo sapiens_hsa03440	1.63088890
18	Allograft rejection_Homo sapiens_hsa05330	1.59189252
19	Phototransduction_Homo sapiens_hsa04744	1.54475538
20	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.53222549
21	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.52191918
22	One carbon pool by folate_Homo sapiens_hsa00670	1.51426478
23	Type I diabetes mellitus_Homo sapiens_hsa04940	1.51023179
24	Graft-versus-host disease_Homo sapiens_hsa05332	1.44261550
25	Fanconi anemia pathway_Homo sapiens_hsa03460	1.43518375
26	Nitrogen metabolism_Homo sapiens_hsa00910	1.37502943
27	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.32102156
28	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.26625692
29	Propanoate metabolism_Homo sapiens_hsa00640	1.26621716
30	RNA degradation_Homo sapiens_hsa03018	1.26616435
31	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.18156312
32	beta-Alanine metabolism_Homo sapiens_hsa00410	1.12152902
33	Base excision repair_Homo sapiens_hsa03410	1.10891018
34	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.10498306
35	Ether lipid metabolism_Homo sapiens_hsa00565	1.10146398
36	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.09249205
37	Sulfur metabolism_Homo sapiens_hsa00920	1.04740473
38	Peroxisome_Homo sapiens_hsa04146	1.00676946
39	Purine metabolism_Homo sapiens_hsa00230	1.00435310
40	Selenocompound metabolism_Homo sapiens_hsa00450	0.98146328
41	Tryptophan metabolism_Homo sapiens_hsa00380	0.98085355
42	Nucleotide excision repair_Homo sapiens_hsa03420	0.96874726
43	Collecting duct acid secretion_Homo sapiens_hsa04966	0.95007593
44	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.93491793
45	Sulfur relay system_Homo sapiens_hsa04122	0.92896144
46	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.92552828
47	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.90743655
48	Regulation of autophagy_Homo sapiens_hsa04140	0.86716662
49	DNA replication_Homo sapiens_hsa03030	0.86624088
50	Spliceosome_Homo sapiens_hsa03040	0.84999590
51	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.84924957
52	Fat digestion and absorption_Homo sapiens_hsa04975	0.84382372
53	Metabolic pathways_Homo sapiens_hsa01100	0.84325495
54	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.83273889
55	Fatty acid elongation_Homo sapiens_hsa00062	0.82395429
56	Basal transcription factors_Homo sapiens_hsa03022	0.81949578
57	Pyruvate metabolism_Homo sapiens_hsa00620	0.77078715
58	Mismatch repair_Homo sapiens_hsa03430	0.74937026
59	Butanoate metabolism_Homo sapiens_hsa00650	0.72980211
60	Rheumatoid arthritis_Homo sapiens_hsa05323	0.70642553
61	RNA transport_Homo sapiens_hsa03013	0.67321760
62	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.63853126
63	Fatty acid degradation_Homo sapiens_hsa00071	0.63132358
64	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.60077686
65	Antigen processing and presentation_Homo sapiens_hsa04612	0.56176783
66	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.55184643
67	Arginine and proline metabolism_Homo sapiens_hsa00330	0.54381991
68	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.54143939
69	Olfactory transduction_Homo sapiens_hsa04740	0.54115480
70	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.54114873
71	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.51707040
72	Primary immunodeficiency_Homo sapiens_hsa05340	0.50637315
73	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.46294388
74	Chemical carcinogenesis_Homo sapiens_hsa05204	0.44749607
75	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.41391903
76	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.39998158
77	Folate biosynthesis_Homo sapiens_hsa00790	0.39748736
78	Glycerolipid metabolism_Homo sapiens_hsa00561	0.38940553
79	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.37657150
80	Retinol metabolism_Homo sapiens_hsa00830	0.37566990
81	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.36383918
82	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.36297669
83	Steroid biosynthesis_Homo sapiens_hsa00100	0.35907631
84	Glutathione metabolism_Homo sapiens_hsa00480	0.35904269
85	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.33461755
86	Caffeine metabolism_Homo sapiens_hsa00232	0.33097751
87	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.32769515
88	Morphine addiction_Homo sapiens_hsa05032	0.31793611
89	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.31499320
90	Nicotine addiction_Homo sapiens_hsa05033	0.30802445
91	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.30063227
92	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.28312446
93	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.26378076
94	Tyrosine metabolism_Homo sapiens_hsa00350	0.25081521
95	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.24884952
96	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.24693785
97	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.24378278
98	Insulin secretion_Homo sapiens_hsa04911	0.24277707
99	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.21770665
100	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.21395510

NACAP3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »