NACAP5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous antigen (GO:0019883)9.76066378
2intra-S DNA damage checkpoint (GO:0031573)8.92400072
3heart trabecula morphogenesis (GO:0061384)8.40629641
4histone H4-K12 acetylation (GO:0043983)7.70166029
5skeletal muscle tissue regeneration (GO:0043403)7.55356354
6regulation of gene silencing by RNA (GO:0060966)7.48266615
7regulation of posttranscriptional gene silencing (GO:0060147)7.48266615
8regulation of gene silencing by miRNA (GO:0060964)7.48266615
9fatty acid elongation (GO:0030497)6.97643112
10negative regulation of gene silencing (GO:0060969)6.79204706
11trabecula morphogenesis (GO:0061383)6.59328857
12negative regulation of striated muscle cell apoptotic process (GO:0010664)6.35178070
13regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901215.33343815
14behavioral response to nicotine (GO:0035095)5.23483097
15positive regulation of skeletal muscle tissue development (GO:0048643)5.16510113
16myoblast migration (GO:0051451)4.95819905
17positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)4.89411123
18macrophage chemotaxis (GO:0048246)4.87583782
19viral transcription (GO:0019083)4.82049495
20regulation of cell proliferation involved in heart morphogenesis (GO:2000136)4.69474922
21translational termination (GO:0006415)4.65702240
22dopamine transport (GO:0015872)4.51844215
23ribosomal small subunit biogenesis (GO:0042274)4.45951947
24mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.36957264
25diol metabolic process (GO:0034311)4.33198749
26regulation of striated muscle cell apoptotic process (GO:0010662)4.30119668
27translational elongation (GO:0006414)4.23434739
28mRNA splice site selection (GO:0006376)4.16141753
29autophagic vacuole fusion (GO:0000046)4.15360191
30ATP synthesis coupled proton transport (GO:0015986)4.02012218
31energy coupled proton transport, down electrochemical gradient (GO:0015985)4.02012218
32SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.92332692
33DNA damage response, detection of DNA damage (GO:0042769)3.90681680
34cotranslational protein targeting to membrane (GO:0006613)3.84486869
35phagocytosis, engulfment (GO:0006911)3.79776737
36transmission of nerve impulse (GO:0019226)3.76546458
37protein targeting to ER (GO:0045047)3.76363395
38microglial cell activation (GO:0001774)3.75719369
39regulation of DNA damage checkpoint (GO:2000001)3.68029267
40protein localization to endoplasmic reticulum (GO:0070972)3.60453810
41positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)3.59379343
42positive regulation of cell cycle G2/M phase transition (GO:1902751)3.59379343
43establishment of protein localization to endoplasmic reticulum (GO:0072599)3.58915923
44sphingoid metabolic process (GO:0046519)3.57275511
45cellular protein complex disassembly (GO:0043624)3.52405414
46membrane tubulation (GO:0097320)3.52370071
47mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.47509832
48ribosomal small subunit assembly (GO:0000028)3.46732971
49viral life cycle (GO:0019058)3.34912460
50mitochondrial calcium ion transport (GO:0006851)3.31378419
51regulation of heart morphogenesis (GO:2000826)3.28510617
52macrophage activation involved in immune response (GO:0002281)3.27119840
53nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.24518164
54DNA integration (GO:0015074)3.22277804
55mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.17549704
56mitochondrial respiratory chain complex I assembly (GO:0032981)3.17549704
57NADH dehydrogenase complex assembly (GO:0010257)3.17549704
58nucleoside diphosphate catabolic process (GO:0009134)3.16148827
59negative regulation of muscle cell apoptotic process (GO:0010656)3.10046323
60translation (GO:0006412)3.07190730
61regulation of endothelial cell differentiation (GO:0045601)3.05124443
62trophectodermal cell differentiation (GO:0001829)3.03479492
63respiratory electron transport chain (GO:0022904)3.00359400
64protein complex biogenesis (GO:0070271)2.97977205
65electron transport chain (GO:0022900)2.97025387
66organelle membrane fusion (GO:0090174)2.96972612
67translational initiation (GO:0006413)2.90170914
68cellular defense response (GO:0006968)2.89026637
69response to pheromone (GO:0019236)2.88348681
70GTP biosynthetic process (GO:0006183)2.86601373
71positive regulation of protein kinase C signaling (GO:0090037)2.82637258
72inner cell mass cell proliferation (GO:0001833)2.80541959
73chaperone-mediated protein transport (GO:0072321)2.80477028
74male meiosis I (GO:0007141)2.79652434
75protein complex disassembly (GO:0043241)2.79232189
76cellular response to gamma radiation (GO:0071480)2.78439599
77mitochondrial respiratory chain complex assembly (GO:0033108)2.75740579
78positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.71290526
79positive regulation of endothelial cell differentiation (GO:0045603)2.70064282
80lymphocyte chemotaxis (GO:0048247)2.68899173
81macromolecular complex disassembly (GO:0032984)2.68678893
82regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.64150752
83ribonucleoprotein complex biogenesis (GO:0022613)2.62069747
84chemokine-mediated signaling pathway (GO:0070098)2.60153951
85catecholamine transport (GO:0051937)2.59915175
86ribosomal large subunit biogenesis (GO:0042273)2.56771826
87antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.56363772
88cullin deneddylation (GO:0010388)2.56213235
89regulation of transcription elongation from RNA polymerase II promoter (GO:0034243)2.56017255
90cellular component biogenesis (GO:0044085)2.53534019
91antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.52308201
92positive regulation of icosanoid secretion (GO:0032305)2.49987591
93tissue regeneration (GO:0042246)2.49590110
94long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.48278061
95purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.46290713
96purine nucleoside triphosphate biosynthetic process (GO:0009145)2.44717681
97positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.43783692
98antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)13.1426246
99antigen processing and presentation of endogenous peptide antigen (GO:0002483)11.9123492
100maturation of SSU-rRNA (GO:0030490)11.1465014

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ELF1_17652178_ChIP-ChIP_JURKAT_Human6.36045543
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.13485206
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.82527176
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.37724339
5IRF8_22096565_ChIP-ChIP_GC-B_Human2.86909978
6EZH2_22144423_ChIP-Seq_EOC_Human2.86284734
7ETS1_20019798_ChIP-Seq_JURKAT_Human2.65003370
8PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.47598034
9CREB1_15753290_ChIP-ChIP_HEK293T_Human2.45578906
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.39295113
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.34778606
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.28718557
13VDR_23849224_ChIP-Seq_CD4+_Human2.26176677
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.17050524
15MYC_18940864_ChIP-ChIP_HL60_Human2.15408003
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.09230717
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.05278035
18EST1_17652178_ChIP-ChIP_JURKAT_Human2.01150471
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.00476873
20TP53_22573176_ChIP-Seq_HFKS_Human1.98813351
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.98539998
22ELK1_19687146_ChIP-ChIP_HELA_Human1.96419453
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.91726503
24NOTCH1_21737748_ChIP-Seq_TLL_Human1.81059017
25CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.79746746
26EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.78899831
27BMI1_23680149_ChIP-Seq_NPCS_Mouse1.76112113
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.75768410
29AR_20517297_ChIP-Seq_VCAP_Human1.71348919
30YY1_22570637_ChIP-Seq_MALME-3M_Human1.63620355
31HTT_18923047_ChIP-ChIP_STHdh_Human1.54873005
32ZNF274_21170338_ChIP-Seq_K562_Hela1.53215280
33MYC_18555785_ChIP-Seq_MESCs_Mouse1.47216743
34VDR_22108803_ChIP-Seq_LS180_Human1.44930944
35EED_16625203_ChIP-ChIP_MESCs_Mouse1.42877685
36STAT1_20625510_ChIP-Seq_HELA_Human1.41592718
37MYC_19079543_ChIP-ChIP_MESCs_Mouse1.40006370
38RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.38794101
39ERG_21242973_ChIP-ChIP_JURKAT_Human1.38633496
40EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.37610989
41GABP_19822575_ChIP-Seq_HepG2_Human1.30189692
42TDRD3_21172665_ChIP-Seq_MCF-7_Human1.29629443
43PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.29263207
44SRF_21415370_ChIP-Seq_HL-1_Mouse1.28347512
45TTF2_22483619_ChIP-Seq_HELA_Human1.27178820
46XRN2_22483619_ChIP-Seq_HELA_Human1.23432525
47CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.23216737
48GATA3_26560356_Chip-Seq_TH2_Human1.16911710
49YY1_21170310_ChIP-Seq_MESCs_Mouse1.16736657
50EGR1_23403033_ChIP-Seq_LIVER_Mouse1.16433897
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.16340310
52TAF2_19829295_ChIP-Seq_ESCs_Human1.16235334
53CTCF_20526341_ChIP-Seq_ESCs_Human1.14268279
54EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.14175714
55ERA_21632823_ChIP-Seq_H3396_Human1.13488131
56SOX2_22085726_ChIP-Seq_NPCs_Mouse1.10088968
57FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.08866190
58SOX2_18555785_ChIP-Seq_MESCs_Mouse1.08858720
59GATA6_21074721_ChIP-Seq_CACO-2_Human1.05992846
60SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.04132188
61EZH2_27304074_Chip-Seq_ESCs_Mouse1.02485650
62BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.01630967
63EGR1_19032775_ChIP-ChIP_M12_Human1.01557170
64ESR1_20079471_ChIP-ChIP_T-47D_Human1.01474081
65BCL6_27268052_Chip-Seq_Bcells_Human1.01389676
66FOXH1_21741376_ChIP-Seq_EPCs_Human1.00527029
67SA1_27219007_Chip-Seq_Bcells_Human1.00044328
68TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.99642582
69MYC_19829295_ChIP-Seq_ESCs_Human0.99299003
70MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.98050834
71FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97958131
72FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.97650514
73NCOR_22424771_ChIP-Seq_293T_Human0.96305807
74MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.94803709
75MYC_18358816_ChIP-ChIP_MESCs_Mouse0.94766007
76GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.93548789
77RNF2_27304074_Chip-Seq_NSC_Mouse0.93281816
78REST_18959480_ChIP-ChIP_MESCs_Mouse0.92785563
79JARID2_20075857_ChIP-Seq_MESCs_Mouse0.92104149
80KLF5_20875108_ChIP-Seq_MESCs_Mouse0.91831835
81SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.89851359
82IGF1R_20145208_ChIP-Seq_DFB_Human0.88948590
83FLI1_27457419_Chip-Seq_LIVER_Mouse0.88794127
84NANOG_20526341_ChIP-Seq_ESCs_Human0.88364243
85CTCF_26484167_Chip-Seq_Bcells_Mouse0.87889348
86BP1_19119308_ChIP-ChIP_Hs578T_Human0.86383908
87CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.86373619
88FUS_26573619_Chip-Seq_HEK293_Human0.85701433
89FOXA1_27270436_Chip-Seq_PROSTATE_Human0.85162650
90FOXA1_25329375_ChIP-Seq_VCAP_Human0.85162650
91ETV2_25802403_ChIP-Seq_MESCs_Mouse0.84919230
92KAP1_22055183_ChIP-Seq_ESCs_Mouse0.84858449
93CTBP1_25329375_ChIP-Seq_LNCAP_Human0.83765699
94ERG_20517297_ChIP-Seq_VCAP_Human0.83246490
95E2F1_20622854_ChIP-Seq_HELA_Human0.83086778
96CBP_20019798_ChIP-Seq_JUKART_Human0.82586811
97IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.82586811
98SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.82519163
99RBPJ_21746931_ChIP-Seq_IB4_Human0.81498101
100FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.81071465

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.08885592
2MP0003567_abnormal_fetal_cardiomyocyte4.31749448
3MP0001529_abnormal_vocalization4.13529312
4MP0002138_abnormal_hepatobiliary_system3.99490247
5MP0006082_CNS_inflammation3.94788451
6MP0005671_abnormal_response_to3.62326926
7MP0004147_increased_porphyrin_level3.40731257
8MP0000750_abnormal_muscle_regeneration2.83953325
9MP0003195_calcinosis2.76788474
10MP0006292_abnormal_olfactory_placode2.50617448
11MP0001188_hyperpigmentation2.50595271
12MP0001348_abnormal_lacrimal_gland2.38844794
13MP0002638_abnormal_pupillary_reflex2.29900543
14MP0009379_abnormal_foot_pigmentation2.28805493
15MP0008260_abnormal_autophagy2.21264103
16MP0006054_spinal_hemorrhage2.13783144
17MP0008875_abnormal_xenobiotic_pharmacok1.95367366
18MP0002160_abnormal_reproductive_system1.94389406
19MP0001986_abnormal_taste_sensitivity1.86050220
20MP0001764_abnormal_homeostasis1.76725700
21MP0004142_abnormal_muscle_tone1.72927562
22MP0000685_abnormal_immune_system1.66594128
23MP0009785_altered_susceptibility_to1.55862109
24MP0002102_abnormal_ear_morphology1.54397773
25MP0009333_abnormal_splenocyte_physiolog1.52776786
26MP0003646_muscle_fatigue1.51610511
27MP0005166_decreased_susceptibility_to1.49598959
28MP0005645_abnormal_hypothalamus_physiol1.48604186
29MP0003936_abnormal_reproductive_system1.43918941
30MP0005551_abnormal_eye_electrophysiolog1.42740908
31MP0005389_reproductive_system_phenotype1.41486188
32MP0000627_abnormal_mammary_gland1.30997460
33MP0004885_abnormal_endolymph1.28297656
34MP0002837_dystrophic_cardiac_calcinosis1.27456324
35MP0003879_abnormal_hair_cell1.26196317
36MP0005025_abnormal_response_to1.23399598
37MP0008877_abnormal_DNA_methylation1.19944916
38MP0003878_abnormal_ear_physiology1.19036634
39MP0005377_hearing/vestibular/ear_phenot1.19036634
40MP0003787_abnormal_imprinting1.18521498
41MP0005646_abnormal_pituitary_gland1.16110684
42MP0006072_abnormal_retinal_apoptosis1.15037992
43MP0003252_abnormal_bile_duct1.14434575
44MP0004145_abnormal_muscle_electrophysio1.11532583
45MP0000462_abnormal_digestive_system1.10819866
46MP0008872_abnormal_physiological_respon1.09937705
47MP0002452_abnormal_antigen_presenting1.08296845
48MP0002420_abnormal_adaptive_immunity1.06398743
49MP0001819_abnormal_immune_cell1.03451847
50MP0005310_abnormal_salivary_gland1.00738298
51MP0000026_abnormal_inner_ear1.00508313
52MP0001915_intracranial_hemorrhage1.00232864
53MP0004019_abnormal_vitamin_homeostasis0.99896550
54MP0001800_abnormal_humoral_immune0.99797801
55MP0000858_altered_metastatic_potential0.97745723
56MP0000049_abnormal_middle_ear0.97599499
57MP0002419_abnormal_innate_immunity0.97543747
58MP0009745_abnormal_behavioral_response0.97145028
59MP0004883_abnormal_blood_vessel0.96839121
60MP0005332_abnormal_amino_acid0.96833168
61MP0003806_abnormal_nucleotide_metabolis0.93472906
62MP0002148_abnormal_hypersensitivity_rea0.90285687
63MP0004185_abnormal_adipocyte_glucose0.90064339
64MP0008789_abnormal_olfactory_epithelium0.89832296
65MP0005360_urolithiasis0.87699634
66MP0005000_abnormal_immune_tolerance0.87674789
67MP0002723_abnormal_immune_serum0.86701010
68MP0003718_maternal_effect0.86145135
69MP0001905_abnormal_dopamine_level0.85876037
70MP0001984_abnormal_olfaction0.85655984
71MP0003011_delayed_dark_adaptation0.84003762
72MP0006276_abnormal_autonomic_nervous0.82787947
73MP0001919_abnormal_reproductive_system0.82575596
74MP0002163_abnormal_gland_morphology0.79945001
75MP0000613_abnormal_salivary_gland0.78266764
76MP0003880_abnormal_central_pattern0.77888901
77MP0005376_homeostasis/metabolism_phenot0.76675554
78MP0000678_abnormal_parathyroid_gland0.76653882
79MP0005164_abnormal_response_to0.75827903
80MP0000631_abnormal_neuroendocrine_gland0.75466166
81MP0001485_abnormal_pinna_reflex0.74731003
82MP0002090_abnormal_vision0.72627955
83MP0001970_abnormal_pain_threshold0.71659207
84MP0003448_altered_tumor_morphology0.71598722
85MP0010234_abnormal_vibrissa_follicle0.70682039
86MP0003183_abnormal_peptide_metabolism0.69350394
87MP0001727_abnormal_embryo_implantation0.68473658
88MP0004043_abnormal_pH_regulation0.68442001
89MP0000013_abnormal_adipose_tissue0.67763555
90MP0002272_abnormal_nervous_system0.67041955
91MP0005253_abnormal_eye_physiology0.67014881
92MP0005197_abnormal_uvea_morphology0.66852165
93MP0010386_abnormal_urinary_bladder0.66820159
94MP0005195_abnormal_posterior_eye0.65917084
95MP0010094_abnormal_chromosome_stability0.64979975
96MP0001119_abnormal_female_reproductive0.64722293
97MP0001486_abnormal_startle_reflex0.64667803
98MP0002277_abnormal_respiratory_mucosa0.63273413
99MP0001664_abnormal_digestion0.61792295
100MP0002210_abnormal_sex_determination0.61310878

Predicted human phenotypes

RankGene SetZ-score
1Nasal polyposis (HP:0100582)8.96817093
2Chronic sinusitis (HP:0011109)8.24596999
3Abnormality of the nasal mucosa (HP:0000433)7.42109638
4Recurrent bronchitis (HP:0002837)6.51983231
5Hypothermia (HP:0002045)6.27149807
6Deep palmar crease (HP:0006191)5.69648423
7Abnormal rod and cone electroretinograms (HP:0008323)5.01715541
8Bony spicule pigmentary retinopathy (HP:0007737)4.00117313
9Bronchitis (HP:0012387)3.99918604
10Absent rod-and cone-mediated responses on ERG (HP:0007688)3.73485326
11Constricted visual fields (HP:0001133)3.60931078
12Congenital stationary night blindness (HP:0007642)3.52300060
13Acute necrotizing encephalopathy (HP:0006965)3.38226000
14Alveolar cell carcinoma (HP:0006519)3.21747390
15Decreased electroretinogram (ERG) amplitude (HP:0000654)3.04318379
16Thickened helices (HP:0000391)3.04306732
17Submucous cleft hard palate (HP:0000176)3.03987838
18Cortical dysplasia (HP:0002539)3.03984276
19Abnormal mitochondria in muscle tissue (HP:0008316)3.00756665
20Scotoma (HP:0000575)2.92633332
21Mitochondrial inheritance (HP:0001427)2.92459206
22Hepatocellular necrosis (HP:0001404)2.82681374
23Ectopia lentis (HP:0001083)2.80910195
24Emphysema (HP:0002097)2.79781508
25Neoplasm of the tracheobronchial system (HP:0100552)2.79483294
26Impulsivity (HP:0100710)2.78855904
27Progressive macrocephaly (HP:0004481)2.69957195
28Acute encephalopathy (HP:0006846)2.65499726
29Bronchiectasis (HP:0002110)2.63955119
30Enlarged epiphyses (HP:0010580)2.63286195
31Increased CSF lactate (HP:0002490)2.59889835
32Exotropia (HP:0000577)2.52973875
33Pustule (HP:0200039)2.48550790
34Hepatic necrosis (HP:0002605)2.46652166
35Abnormality of alanine metabolism (HP:0010916)2.35979462
36Hyperalaninemia (HP:0003348)2.35979462
37Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.35979462
38Severe visual impairment (HP:0001141)2.35021079
39Epidermoid cyst (HP:0200040)2.34831168
403-Methylglutaconic aciduria (HP:0003535)2.32809980
41Attenuation of retinal blood vessels (HP:0007843)2.32348074
42Congenital, generalized hypertrichosis (HP:0004540)2.32129758
43Dyschromatopsia (HP:0007641)2.28296826
44Hyperlipoproteinemia (HP:0010980)2.26370199
45Decreased central vision (HP:0007663)2.25710881
46Thick nail (HP:0001805)2.25175784
47Optic disc pallor (HP:0000543)2.15043465
48Poor head control (HP:0002421)2.14179257
49Cerebral edema (HP:0002181)2.13849688
50Increased serum lactate (HP:0002151)2.11432033
51Increased hepatocellular lipid droplets (HP:0006565)2.10071798
52Central scotoma (HP:0000603)2.09436094
53Hypoproteinemia (HP:0003075)2.08363393
54Abolished electroretinogram (ERG) (HP:0000550)2.07272782
55Abnormality of hair growth rate (HP:0011363)2.06395584
56Slow-growing hair (HP:0002217)2.06395584
57Agammaglobulinemia (HP:0004432)2.05026255
58Chronic otitis media (HP:0000389)12.0324881
59Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.96413914
60Macrocytic anemia (HP:0001972)1.91032039
61Progressive microcephaly (HP:0000253)1.90145512
62Renal Fanconi syndrome (HP:0001994)1.88950358
63Respiratory difficulties (HP:0002880)1.88440355
64Abnormality of macular pigmentation (HP:0008002)1.86464235
65Global brain atrophy (HP:0002283)1.81640976
66Joint swelling (HP:0001386)1.77661236
67Lactic acidosis (HP:0003128)1.76725511
68Clumsiness (HP:0002312)1.76586686
69Hypoplasia of the radius (HP:0002984)1.74893988
70Bulbous nose (HP:0000414)1.74802717
71Lipid accumulation in hepatocytes (HP:0006561)1.74596863
72Abnormality of the epiphysis of the femoral head (HP:0010574)1.73596929
73Amelogenesis imperfecta (HP:0000705)1.70236125
74Underdeveloped supraorbital ridges (HP:0009891)1.70171671
75Lethargy (HP:0001254)1.69382218
76Medial flaring of the eyebrow (HP:0010747)1.68983055
77Large for gestational age (HP:0001520)1.65929500
78Flat capital femoral epiphysis (HP:0003370)1.64148516
79Oligomenorrhea (HP:0000876)1.63965195
80Pachygyria (HP:0001302)1.63916211
81Forearm undergrowth (HP:0009821)1.62126803
82Hypophosphatemic rickets (HP:0004912)1.62110632
83Thyroid-stimulating hormone excess (HP:0002925)1.61869664
84Abnormality of femoral epiphyses (HP:0006499)1.58404564
85Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.58404564
86Curly hair (HP:0002212)1.56542116
87Alkalosis (HP:0001948)1.55425523
88Generalized amyotrophy (HP:0003700)1.54833911
89Melanoma (HP:0002861)1.54480005
90Retinitis pigmentosa (HP:0000510)1.54064000
91Fibular aplasia (HP:0002990)1.53808985
92Esophageal atresia (HP:0002032)1.53112591
93Abnormality of the femoral head (HP:0003368)1.52214494
94Pigmentary retinal degeneration (HP:0001146)1.52154947
95Chronic diarrhea (HP:0002028)1.51528949
96Recurrent bacterial skin infections (HP:0005406)1.49840292
97Rib fusion (HP:0000902)1.49503809
98Septo-optic dysplasia (HP:0100842)1.47804585
99Type I transferrin isoform profile (HP:0003642)1.47238358
100Increased intramyocellular lipid droplets (HP:0012240)1.45352601

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K139.53964028
2AKT34.57007372
3IRAK44.14988042
4BRAF4.07768768
5TLK14.03785360
6ILK3.27151636
7ARAF3.24793903
8TAOK33.18102440
9TAF13.17379734
10MAP3K93.08658215
11BMPR22.57223555
12TXK2.54059836
13KSR12.13018016
14MOS1.74511137
15MAP3K141.67825087
16PIK3CG1.67038081
17MARK31.31137002
18TIE11.07323358
19SCYL20.99834816
20BCKDK0.96937358
21SGK20.77199422
22MAP4K20.74543429
23MAP3K80.72635644
24GRK10.71986873
25PTK20.71561297
26BMPR1B0.64308968
27ADRBK20.63825988
28TSSK60.62190828
29WNK40.61496127
30IKBKB0.58982523
31KSR20.55547820
32MAP3K70.54708509
33BTK0.54420425
34EPHA20.53968886
35MARK10.51740046
36INSRR0.51084670
37MAPK130.48005326
38LRRK20.47868604
39PIM10.46742937
40HCK0.46656656
41SGK4940.45694067
42SGK2230.45694067
43PRKCI0.45433951
44KIT0.44595846
45CHUK0.43795110
46PIM20.41765004
47MAP2K60.40783932
48NME20.39754439
49CDK190.38866869
50MAP3K110.38358092
51LIMK10.37661716
52RAF10.36872487
53CHEK10.36861002
54SYK0.35821452
55PAK10.34763808
56OXSR10.34530086
57MAP4K10.33297277
58OBSCN0.31753482
59ACVR1B0.31511987
60MAP2K70.30273017
61NLK0.29968409
62WNK30.28675640
63CSNK2A10.28511841
64CSNK2A20.28062533
65SGK30.28009996
66PLK20.26746968
67DAPK10.26087422
68MAPKAPK50.25817211
69MAP2K40.25567857
70PASK0.25264047
71NME10.24895694
72ZAK0.24644264
73STK390.23573245
74PLK10.23468684
75NEK20.23182423
76PRKCZ0.23126727
77STK38L0.21290527
78EPHA40.19885343
79ABL20.19580545
80SGK10.19010795
81PRKCQ0.18731834
82CDK140.18628169
83ERBB30.18524244
84PRKACA0.18073588
85MAP2K10.18043519
86CSNK1E0.16670884
87MYLK0.15867338
88AURKB0.15457878
89HIPK20.13609677
90MUSK0.13283045
91TRIM280.13128339
92MAP3K120.11743263
93CDK11A0.11284604
94CAMK2A0.11057201
95FRK0.11048666
96CDK150.10209084
97TEC0.10132618
98STK160.09875177
99CDK180.09504471
100DAPK30.09425955

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.54391422
2Oxidative phosphorylation_Homo sapiens_hsa001904.25727235
3Fatty acid elongation_Homo sapiens_hsa000623.86061932
4Parkinsons disease_Homo sapiens_hsa050123.40913538
5Proteasome_Homo sapiens_hsa030503.11101198
6Linoleic acid metabolism_Homo sapiens_hsa005912.41569572
7Phototransduction_Homo sapiens_hsa047442.34001968
8Huntingtons disease_Homo sapiens_hsa050162.31365538
9Alzheimers disease_Homo sapiens_hsa050102.24000665
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.22741788
11Antigen processing and presentation_Homo sapiens_hsa046122.20830730
12Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.20656677
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.16938587
14Intestinal immune network for IgA production_Homo sapiens_hsa046721.97949690
15Asthma_Homo sapiens_hsa053101.90619044
16Thyroid cancer_Homo sapiens_hsa052161.82771815
17Autoimmune thyroid disease_Homo sapiens_hsa053201.72437383
18Allograft rejection_Homo sapiens_hsa053301.71543939
19Cardiac muscle contraction_Homo sapiens_hsa042601.71491084
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.67727580
21RNA polymerase_Homo sapiens_hsa030201.64329071
22Regulation of autophagy_Homo sapiens_hsa041401.61112180
23Graft-versus-host disease_Homo sapiens_hsa053321.60662253
24Homologous recombination_Homo sapiens_hsa034401.59962364
25Spliceosome_Homo sapiens_hsa030401.52020288
26Olfactory transduction_Homo sapiens_hsa047401.50071736
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.37702777
28Nitrogen metabolism_Homo sapiens_hsa009101.32977532
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.32869858
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.22196132
31Collecting duct acid secretion_Homo sapiens_hsa049661.13769653
32Fat digestion and absorption_Homo sapiens_hsa049751.11763715
33Pyrimidine metabolism_Homo sapiens_hsa002401.10910893
34Fatty acid degradation_Homo sapiens_hsa000711.10899249
35Type I diabetes mellitus_Homo sapiens_hsa049401.09617286
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.05831713
37Arachidonic acid metabolism_Homo sapiens_hsa005900.99421032
38Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.93969921
39Fatty acid metabolism_Homo sapiens_hsa012120.86255267
40Basal transcription factors_Homo sapiens_hsa030220.86154745
41Sulfur relay system_Homo sapiens_hsa041220.86123023
42Nicotine addiction_Homo sapiens_hsa050330.86084923
43Maturity onset diabetes of the young_Homo sapiens_hsa049500.82363265
44RNA degradation_Homo sapiens_hsa030180.82185441
45Ether lipid metabolism_Homo sapiens_hsa005650.81539410
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.76367329
47Systemic lupus erythematosus_Homo sapiens_hsa053220.69893341
48Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.69471946
49Purine metabolism_Homo sapiens_hsa002300.69294715
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.68897582
51Leishmaniasis_Homo sapiens_hsa051400.67875208
52Steroid biosynthesis_Homo sapiens_hsa001000.64239517
53Staphylococcus aureus infection_Homo sapiens_hsa051500.58071107
54Apoptosis_Homo sapiens_hsa042100.57908774
55Butanoate metabolism_Homo sapiens_hsa006500.57877923
56Protein export_Homo sapiens_hsa030600.57788492
57T cell receptor signaling pathway_Homo sapiens_hsa046600.57270956
58NF-kappa B signaling pathway_Homo sapiens_hsa040640.56191472
59Retinol metabolism_Homo sapiens_hsa008300.55011853
60Rheumatoid arthritis_Homo sapiens_hsa053230.54791506
61Toll-like receptor signaling pathway_Homo sapiens_hsa046200.52560335
62Steroid hormone biosynthesis_Homo sapiens_hsa001400.50705992
63Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.50194742
64Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.49175528
65Vitamin B6 metabolism_Homo sapiens_hsa007500.48955665
66Chemical carcinogenesis_Homo sapiens_hsa052040.48725720
67Metabolic pathways_Homo sapiens_hsa011000.46330335
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45976861
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45808552
70Bladder cancer_Homo sapiens_hsa052190.45466941
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.44655768
72Mineral absorption_Homo sapiens_hsa049780.43837200
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42229593
74Primary immunodeficiency_Homo sapiens_hsa053400.40090576
75Fanconi anemia pathway_Homo sapiens_hsa034600.39755745
76Cysteine and methionine metabolism_Homo sapiens_hsa002700.39531531
77Chemokine signaling pathway_Homo sapiens_hsa040620.39027186
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37623668
79Sulfur metabolism_Homo sapiens_hsa009200.33342362
80Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.32130793
81Malaria_Homo sapiens_hsa051440.31474533
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31408792
83One carbon pool by folate_Homo sapiens_hsa006700.29128828
84Melanoma_Homo sapiens_hsa052180.28832862
85NOD-like receptor signaling pathway_Homo sapiens_hsa046210.27672754
86Renin-angiotensin system_Homo sapiens_hsa046140.27333488
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.26242435
88Osteoclast differentiation_Homo sapiens_hsa043800.21721136
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.20937907
90Hematopoietic cell lineage_Homo sapiens_hsa046400.18761031
91Vascular smooth muscle contraction_Homo sapiens_hsa042700.18742784
92Caffeine metabolism_Homo sapiens_hsa002320.16878681
93Tyrosine metabolism_Homo sapiens_hsa003500.16580801
94Hepatitis C_Homo sapiens_hsa051600.16081450
95Acute myeloid leukemia_Homo sapiens_hsa052210.15135179
96Serotonergic synapse_Homo sapiens_hsa047260.14176263
97Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.10402047
98Long-term depression_Homo sapiens_hsa047300.10248322
99Viral myocarditis_Homo sapiens_hsa054160.07615059
100Insulin secretion_Homo sapiens_hsa049110.07483133

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