ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein neddylation (GO:0045116)	4.74749635
2	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.71668010
3	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.63564835
4	ATP synthesis coupled proton transport (GO:0015986)	4.63564835
5	one-carbon compound transport (GO:0019755)	4.54583884
6	DNA deamination (GO:0045006)	4.33441167
7	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	4.15227884
8	proteasome assembly (GO:0043248)	3.92449154
9	GTP biosynthetic process (GO:0006183)	3.89148291
10	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.81251007
11	auditory receptor cell stereocilium organization (GO:0060088)	3.57057054
12	positive regulation of interleukin-17 production (GO:0032740)	3.55087143
13	UTP metabolic process (GO:0046051)	3.52745373
14	negative regulation of thymocyte apoptotic process (GO:0070244)	3.45793871
15	regulation of isotype switching to IgG isotypes (GO:0048302)	3.42214888
16	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.36522747
17	ribosomal large subunit biogenesis (GO:0042273)	3.28278604
18	UTP biosynthetic process (GO:0006228)	3.23356869
19	coenzyme catabolic process (GO:0009109)	3.15154421
20	signal peptide processing (GO:0006465)	3.14846604
21	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.12869429
22	negative regulation of T cell differentiation in thymus (GO:0033085)	3.08964327
23	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.03822233
24	positive regulation of lamellipodium assembly (GO:0010592)	3.02942141
25	oxidative phosphorylation (GO:0006119)	3.01863854
26	L-fucose catabolic process (GO:0042355)	3.01344427
27	fucose catabolic process (GO:0019317)	3.01344427
28	L-fucose metabolic process (GO:0042354)	3.01344427
29	regulation of regulatory T cell differentiation (GO:0045589)	3.00726867
30	positive regulation of defense response to virus by host (GO:0002230)	2.99177050
31	dopamine transport (GO:0015872)	2.98878696
32	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.97489691
33	piRNA metabolic process (GO:0034587)	2.97145844
34	negative regulation of heart rate (GO:0010459)	2.94366602
35	cellular response to exogenous dsRNA (GO:0071360)	2.93394554
36	ATP biosynthetic process (GO:0006754)	2.88781367
37	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.87976037
38	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.87976037
39	NADH dehydrogenase complex assembly (GO:0010257)	2.87976037
40	indolalkylamine metabolic process (GO:0006586)	2.87371806
41	negative regulation of B cell apoptotic process (GO:0002903)	2.86923879
42	cytidine metabolic process (GO:0046087)	2.85047493
43	cytidine catabolic process (GO:0006216)	2.85047493
44	cytidine deamination (GO:0009972)	2.85047493
45	mitochondrial respiratory chain complex assembly (GO:0033108)	2.81601446
46	negative regulation of macrophage differentiation (GO:0045650)	2.81154570
47	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.79403952
48	guanosine-containing compound biosynthetic process (GO:1901070)	2.79345299
49	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.79238082
50	ubiquinone biosynthetic process (GO:0006744)	2.78708398
51	water-soluble vitamin biosynthetic process (GO:0042364)	2.77031077
52	regulation of B cell apoptotic process (GO:0002902)	2.75992832
53	respiratory electron transport chain (GO:0022904)	2.73974083
54	histone mRNA metabolic process (GO:0008334)	2.73782886
55	protein complex biogenesis (GO:0070271)	2.72026871
56	electron transport chain (GO:0022900)	2.70760247
57	ubiquinone metabolic process (GO:0006743)	2.70748563
58	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.70600372
59	protein K6-linked ubiquitination (GO:0085020)	2.70200303
60	epithelial cilium movement (GO:0003351)	2.69960496
61	hydrogen ion transmembrane transport (GO:1902600)	2.69126109
62	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.68775831
63	termination of RNA polymerase III transcription (GO:0006386)	2.68775831
64	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.64841050
65	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.64204573
66	translation (GO:0006412)	2.63992440
67	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.62358075
68	positive regulation of T-helper 1 type immune response (GO:0002827)	2.61737628
69	left/right axis specification (GO:0070986)	2.60800295
70	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.58443216
71	kynurenine metabolic process (GO:0070189)	2.56929500
72	peptidyl-histidine modification (GO:0018202)	2.56133470
73	viral mRNA export from host cell nucleus (GO:0046784)	2.54782248
74	CTP metabolic process (GO:0046036)	2.54326296
75	CTP biosynthetic process (GO:0006241)	2.54326296
76	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.54291472
77	regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)	2.53282178
78	gene silencing by RNA (GO:0031047)	2.52840483
79	cotranslational protein targeting to membrane (GO:0006613)	2.52262992
80	viral transcription (GO:0019083)	2.52240228
81	anterograde synaptic vesicle transport (GO:0048490)	2.50641532
82	protein targeting to ER (GO:0045047)	2.50556965
83	negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)	2.49732582
84	mast cell degranulation (GO:0043303)	2.49620753
85	mast cell activation involved in immune response (GO:0002279)	2.49620753
86	proton transport (GO:0015992)	2.49612771
87	negative regulation of T cell apoptotic process (GO:0070233)	2.49046510
88	positive regulation of prostaglandin secretion (GO:0032308)	2.48937559
89	negative regulation of lymphocyte apoptotic process (GO:0070229)	2.47294040
90	protein localization to endoplasmic reticulum (GO:0070972)	2.47273700
91	hydrogen transport (GO:0006818)	2.46739856
92	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.46459799
93	B cell differentiation (GO:0030183)	2.45635118
94	regulation of cellular amino acid metabolic process (GO:0006521)	2.44708834
95	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.44325864
96	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.44325864
97	translational termination (GO:0006415)	2.43199842
98	polyol transport (GO:0015791)	2.42761102
99	formation of translation preinitiation complex (GO:0001731)	2.42758709
100	response to pheromone (GO:0019236)	2.41706075

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.62237377
2	VDR_22108803_ChIP-Seq_LS180_Human	3.50561530
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.36375728
4	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.18908341
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.93299274
6	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.89554014
7	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.82444664
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.81181500
9	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.74056595
10	IRF1_19129219_ChIP-ChIP_H3396_Human	2.42831179
11	VDR_23849224_ChIP-Seq_CD4+_Human	2.38758128
12	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.38190385
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.11301902
14	ELK1_19687146_ChIP-ChIP_HELA_Human	2.05461777
15	IGF1R_20145208_ChIP-Seq_DFB_Human	2.02982772
16	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.01328747
17	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.99899345
18	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.99837714
19	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.99696456
20	EWS_26573619_Chip-Seq_HEK293_Human	1.91619654
21	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.87802467
22	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.80371096
23	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.79000225
24	MYC_18940864_ChIP-ChIP_HL60_Human	1.77076774
25	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.69698172
26	ER_23166858_ChIP-Seq_MCF-7_Human	1.68912517
27	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.68340207
28	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.68340207
29	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.66904495
30	CBP_20019798_ChIP-Seq_JUKART_Human	1.66904495
31	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.65068663
32	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.64034819
33	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.61658430
34	FOXP3_21729870_ChIP-Seq_TREG_Human	1.60345786
35	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.59227707
36	P300_19829295_ChIP-Seq_ESCs_Human	1.54902137
37	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.53099368
38	TAF15_26573619_Chip-Seq_HEK293_Human	1.51664638
39	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.47990730
40	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.46211546
41	SOX2_19829295_ChIP-Seq_ESCs_Human	1.42589367
42	NANOG_19829295_ChIP-Seq_ESCs_Human	1.42589367
43	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.41978314
44	AR_20517297_ChIP-Seq_VCAP_Human	1.39914337
45	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.38669746
46	GATA3_26560356_Chip-Seq_TH2_Human	1.37398242
47	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.34521277
48	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.34430741
49	EZH2_22144423_ChIP-Seq_EOC_Human	1.33480091
50	TP53_22573176_ChIP-Seq_HFKS_Human	1.28472760
51	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.27543568
52	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.26823695
53	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.25692319
54	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.25167253
55	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.24791855
56	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.22819919
57	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.22675695
58	BCAT_22108803_ChIP-Seq_LS180_Human	1.22591508
59	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.22501039
60	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.22265679
61	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.21414253
62	TCF4_22108803_ChIP-Seq_LS180_Human	1.21145025
63	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.18043836
64	TAF2_19829295_ChIP-Seq_ESCs_Human	1.17472485
65	NCOR_22424771_ChIP-Seq_293T_Human	1.17283733
66	CDX2_22108803_ChIP-Seq_LS180_Human	1.15458502
67	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.15322997
68	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.13548876
69	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.13211284
70	MYC_19829295_ChIP-Seq_ESCs_Human	1.10763885
71	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.09491525
72	FUS_26573619_Chip-Seq_HEK293_Human	1.09299910
73	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.08952249
74	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.08605110
75	TTF2_22483619_ChIP-Seq_HELA_Human	1.07932964
76	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.07859562
77	MYB_26560356_Chip-Seq_TH2_Human	1.07742491
78	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.05007298
79	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.04107843
80	GATA3_27048872_Chip-Seq_THYMUS_Human	1.03742498
81	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.02365394
82	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.01424291
83	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.01200795
84	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.00494358
85	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.99579732
86	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.98769594
87	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	0.98538521
88	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.97694760
89	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.95767531
90	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	0.95540806
91	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.94530719
92	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.94149473
93	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.94138750
94	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.93875246
95	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.93488335
96	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.93091292
97	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.92209076
98	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.91357647
99	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.91204206
100	HOXB7_26014856_ChIP-Seq_BT474_Human	0.90569052

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001835_abnormal_antigen_presentation	4.72190682
2	MP0002138_abnormal_hepatobiliary_system	4.36488530
3	MP0002166_altered_tumor_susceptibility	3.27400827
4	MP0005671_abnormal_response_to	3.01723846
5	MP0002006_tumorigenesis	2.76891560
6	MP0004145_abnormal_muscle_electrophysio	2.38981105
7	MP0003806_abnormal_nucleotide_metabolis	2.36540492
8	MP0005075_abnormal_melanosome_morpholog	2.27737495
9	MP0004147_increased_porphyrin_level	2.20765536
10	MP0001968_abnormal_touch/_nociception	2.14455251
11	MP0003195_calcinosis	2.08287536
12	MP0002876_abnormal_thyroid_physiology	2.07851120
13	MP0005645_abnormal_hypothalamus_physiol	2.04381060
14	MP0008007_abnormal_cellular_replicative	2.04293877
15	MP0002148_abnormal_hypersensitivity_rea	1.97434449
16	MP0006072_abnormal_retinal_apoptosis	1.96553097
17	MP0005451_abnormal_body_composition	1.91787012
18	MP0002638_abnormal_pupillary_reflex	1.89309182
19	MP0006292_abnormal_olfactory_placode	1.85556141
20	MP0009785_altered_susceptibility_to	1.80640117
21	MP0003880_abnormal_central_pattern	1.80000681
22	MP0001800_abnormal_humoral_immune	1.75617485
23	MP0001905_abnormal_dopamine_level	1.67412993
24	MP0005084_abnormal_gallbladder_morpholo	1.60638019
25	MP0001790_abnormal_immune_system	1.59403144
26	MP0005387_immune_system_phenotype	1.59403144
27	MP0005646_abnormal_pituitary_gland	1.58594966
28	MP0009278_abnormal_bone_marrow	1.55362347
29	MP0009697_abnormal_copulation	1.50556726
30	MP0004885_abnormal_endolymph	1.44013654
31	MP0001188_hyperpigmentation	1.42668283
32	MP0002837_dystrophic_cardiac_calcinosis	1.38879694
33	MP0000685_abnormal_immune_system	1.38371634
34	MP0001986_abnormal_taste_sensitivity	1.35408200
35	MP0005551_abnormal_eye_electrophysiolog	1.34637540
36	MP0005332_abnormal_amino_acid	1.32785860
37	MP0001984_abnormal_olfaction	1.31228138
38	MP0002452_abnormal_antigen_presenting	1.30750927
39	MP0002736_abnormal_nociception_after	1.29779052
40	MP0006276_abnormal_autonomic_nervous	1.28402557
41	MP0002938_white_spotting	1.27838577
42	MP0004142_abnormal_muscle_tone	1.27649310
43	MP0005253_abnormal_eye_physiology	1.27040558
44	MP0004742_abnormal_vestibular_system	1.25074579
45	MP0002723_abnormal_immune_serum	1.23820854
46	MP0005410_abnormal_fertilization	1.22803833
47	MP0002909_abnormal_adrenal_gland	1.20563804
48	MP0005000_abnormal_immune_tolerance	1.19008562
49	MP0002009_preneoplasia	1.12522745
50	MP0008872_abnormal_physiological_respon	1.10471297
51	MP0003786_premature_aging	1.09294377
52	MP0008875_abnormal_xenobiotic_pharmacok	1.06716934
53	MP0008775_abnormal_heart_ventricle	1.03759733
54	MP0010386_abnormal_urinary_bladder	1.03538280
55	MP0005360_urolithiasis	1.02599388
56	MP0005389_reproductive_system_phenotype	1.02231941
57	MP0001819_abnormal_immune_cell	1.02055466
58	MP0001661_extended_life_span	1.02019989
59	MP0009745_abnormal_behavioral_response	1.01374453
60	MP0002653_abnormal_ependyma_morphology	1.00899554
61	MP0001970_abnormal_pain_threshold	1.00866037
62	MP0001919_abnormal_reproductive_system	1.00621985
63	MP0009333_abnormal_splenocyte_physiolog	1.00184426
64	MP0002420_abnormal_adaptive_immunity	0.99624724
65	MP0008877_abnormal_DNA_methylation	0.99339351
66	MP0001845_abnormal_inflammatory_respons	0.98490719
67	MP0005408_hypopigmentation	0.96216878
68	MP0001853_heart_inflammation	0.95096093
69	MP0003787_abnormal_imprinting	0.94192910
70	MP0006036_abnormal_mitochondrial_physio	0.92203020
71	MP0001529_abnormal_vocalization	0.90442782
72	MP0005379_endocrine/exocrine_gland_phen	0.89074795
73	MP0001879_abnormal_lymphatic_vessel	0.88621997
74	MP0002733_abnormal_thermal_nociception	0.87424588
75	MP0001502_abnormal_circadian_rhythm	0.87128460
76	MP0002272_abnormal_nervous_system	0.86759946
77	MP0000613_abnormal_salivary_gland	0.86176672
78	MP0002398_abnormal_bone_marrow	0.83986417
79	MP0001545_abnormal_hematopoietic_system	0.83868674
80	MP0005397_hematopoietic_system_phenotyp	0.83868674
81	MP0001663_abnormal_digestive_system	0.83503182
82	MP0010094_abnormal_chromosome_stability	0.80501838
83	MP0002735_abnormal_chemical_nociception	0.80203905
84	MP0001873_stomach_inflammation	0.80092488
85	MP0005220_abnormal_exocrine_pancreas	0.80054802
86	MP0000716_abnormal_immune_system	0.76775629
87	MP0005535_abnormal_body_temperature	0.76350545
88	MP0002734_abnormal_mechanical_nocicepti	0.76186734
89	MP0000566_synostosis	0.76033706
90	MP0002933_joint_inflammation	0.75443151
91	MP0002095_abnormal_skin_pigmentation	0.75051501
92	MP0002132_abnormal_respiratory_system	0.75009204
93	MP0005377_hearing/vestibular/ear_phenot	0.74602618
94	MP0003878_abnormal_ear_physiology	0.74602618
95	MP0003763_abnormal_thymus_physiology	0.73459927
96	MP0000631_abnormal_neuroendocrine_gland	0.73231961
97	MP0000372_irregular_coat_pigmentation	0.72488688
98	MP0008058_abnormal_DNA_repair	0.71696210
99	MP0001765_abnormal_ion_homeostasis	0.71263055
100	MP0010155_abnormal_intestine_physiology	0.70572298

Predicted human phenotypes

Rank	Gene Set	Z-score
1	B lymphocytopenia (HP:0010976)	5.87004497
2	Abnormality of B cell number (HP:0010975)	5.34320521
3	Thyroiditis (HP:0100646)	5.31039509
4	Panhypogammaglobulinemia (HP:0003139)	4.95510791
5	Severe combined immunodeficiency (HP:0004430)	4.93341393
6	Hypoplasia of the thymus (HP:0000778)	4.78642480
7	Absent rod-and cone-mediated responses on ERG (HP:0007688)	4.70165414
8	Hypoproteinemia (HP:0003075)	4.54035074
9	Abnormal rod and cone electroretinograms (HP:0008323)	4.01504898
10	Decreased central vision (HP:0007663)	3.94908301
11	Combined immunodeficiency (HP:0005387)	3.74821709
12	Molar tooth sign on MRI (HP:0002419)	3.74499694
13	Abnormality of midbrain morphology (HP:0002418)	3.74499694
14	IgG deficiency (HP:0004315)	3.62509559
15	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.46407384
16	Absent/shortened dynein arms (HP:0200106)	3.46407384
17	Pancreatic cysts (HP:0001737)	3.32673541
18	Type II lissencephaly (HP:0007260)	3.31643569
19	Hyperglycinuria (HP:0003108)	3.04813569
20	Eosinophilia (HP:0001880)	3.00112571
21	Abolished electroretinogram (ERG) (HP:0000550)	2.94296652
22	Attenuation of retinal blood vessels (HP:0007843)	2.92140038
23	T lymphocytopenia (HP:0005403)	2.88391663
24	Chronic sinusitis (HP:0011109)	2.86167159
25	Abnormality of eosinophils (HP:0001879)	2.85008064
26	Mitochondrial inheritance (HP:0001427)	2.83867598
27	Elevated erythrocyte sedimentation rate (HP:0003565)	2.83144089
28	3-Methylglutaconic aciduria (HP:0003535)	2.82582221
29	Pancreatic fibrosis (HP:0100732)	2.81124827
30	Acute necrotizing encephalopathy (HP:0006965)	2.74437139
31	True hermaphroditism (HP:0010459)	2.71307128
32	Erythroderma (HP:0001019)	2.69826192
33	Constricted visual fields (HP:0001133)	2.56458238
34	Progressive macrocephaly (HP:0004481)	2.53492339
35	Abnormal mitochondria in muscle tissue (HP:0008316)	2.50496643
36	Increased hepatocellular lipid droplets (HP:0006565)	2.48505544
37	Increased CSF lactate (HP:0002490)	2.45253319
38	Congenital stationary night blindness (HP:0007642)	2.44804548
39	Agammaglobulinemia (HP:0004432)	2.44239928
40	Bile duct proliferation (HP:0001408)	2.43714901
41	Abnormal biliary tract physiology (HP:0012439)	2.43714901
42	Abnormality of T cell number (HP:0011839)	2.43697961
43	Abnormality of alanine metabolism (HP:0010916)	2.43665242
44	Hyperalaninemia (HP:0003348)	2.43665242
45	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.43665242
46	Renal cortical cysts (HP:0000803)	2.41998441
47	Nephronophthisis (HP:0000090)	2.41103265
48	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.36469313
49	Lipid accumulation in hepatocytes (HP:0006561)	2.35533112
50	Hypothermia (HP:0002045)	2.34015276
51	Retinal dysplasia (HP:0007973)	2.32045939
52	Poikiloderma (HP:0001029)	2.31926164
53	Increased intramyocellular lipid droplets (HP:0012240)	2.31872977
54	Hepatocellular necrosis (HP:0001404)	2.30929637
55	Acute encephalopathy (HP:0006846)	2.28120227
56	Abnormality of macular pigmentation (HP:0008002)	2.26401003
57	Cerebral edema (HP:0002181)	2.22528435
58	Entropion (HP:0000621)	2.20537429
59	Methylmalonic aciduria (HP:0012120)	2.20334056
60	Abnormal ciliary motility (HP:0012262)	2.19809615
61	Congenital, generalized hypertrichosis (HP:0004540)	2.17285830
62	Mesangial abnormality (HP:0001966)	2.16423517
63	Posterior subcapsular cataract (HP:0007787)	2.15944389
64	Bony spicule pigmentary retinopathy (HP:0007737)	2.14927251
65	Aplastic anemia (HP:0001915)	2.14018125
66	Hepatic necrosis (HP:0002605)	2.12659486
67	Microretrognathia (HP:0000308)	2.12618396
68	Renal Fanconi syndrome (HP:0001994)	2.11479502
69	Methylmalonic acidemia (HP:0002912)	2.10143839
70	Recurrent fungal infections (HP:0002841)	2.09877703
71	Abnormal respiratory epithelium morphology (HP:0012253)	2.07660137
72	Abnormal respiratory motile cilium morphology (HP:0005938)	2.07660137
73	Granulocytopenia (HP:0001913)	2.07421108
74	Optic disc pallor (HP:0000543)	2.06808205
75	Muscle hypertrophy of the lower extremities (HP:0008968)	2.06262840
76	Abnormality of serine family amino acid metabolism (HP:0010894)	2.05723751
77	Abnormality of glycine metabolism (HP:0010895)	2.05723751
78	Recurrent viral infections (HP:0004429)	2.03900279
79	Aplasia/hypoplasia of the uterus (HP:0008684)	2.03695892
80	Abnormality of the renal medulla (HP:0100957)	2.03654630
81	Hyperventilation (HP:0002883)	1.96589999
82	Increased muscle lipid content (HP:0009058)	1.93891601
83	Sensorimotor neuropathy (HP:0007141)	1.93824313
84	Increased serum lactate (HP:0002151)	1.93593287
85	Meningitis (HP:0001287)	1.93090829
86	Abnormality of DNA repair (HP:0003254)	1.90032993
87	Cystic liver disease (HP:0006706)	1.89754859
88	Exertional dyspnea (HP:0002875)	1.88944105
89	Pendular nystagmus (HP:0012043)	1.87389844
90	Abnormality of the prostate (HP:0008775)	1.85650816
91	Central scotoma (HP:0000603)	1.85075381
92	Bifid tongue (HP:0010297)	1.84482503
93	Lethargy (HP:0001254)	1.84329621
94	Dicarboxylic aciduria (HP:0003215)	1.83000900
95	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.83000900
96	Lactic acidosis (HP:0003128)	1.82648058
97	Keratoconus (HP:0000563)	1.81376735
98	Increased corneal curvature (HP:0100692)	1.81376735
99	Type 2 muscle fiber atrophy (HP:0003554)	1.80263450
100	Abnormality of the renal cortex (HP:0011035)	1.74717538

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CDK19	4.59529283
2	FRK	4.07137829
3	BMPR1B	3.62884968
4	KIT	2.91299382
5	EIF2AK3	2.70540968
6	TLK1	2.52660193
7	STK16	2.46254287
8	ADRBK2	2.31958846
9	TGFBR1	2.30499980
10	NUAK1	2.27709249
11	PIK3CG	2.22045233
12	GRK1	2.13215971
13	BMPR2	2.03884145
14	TEC	1.96269175
15	ZAK	1.92458774
16	FLT3	1.89266708
17	PINK1	1.84035637
18	ITK	1.75250909
19	MAP4K2	1.70533704
20	MAP3K12	1.62550659
21	CSNK1G3	1.55495009
22	ACVR1B	1.51902618
23	VRK1	1.50996895
24	VRK2	1.50930799
25	CSNK1G1	1.48539397
26	CSNK1G2	1.29025937
27	WNK4	1.27799484
28	CSF1R	1.24223247
29	TXK	1.23231310
30	CDK8	1.21734420
31	BCKDK	1.19288835
32	MYLK	1.18863725
33	TSSK6	1.16340366
34	ILK	1.15152550
35	DAPK1	1.11710959
36	MST4	1.11361262
37	PDK2	1.09156995
38	PRKCE	1.00902981
39	FGFR2	0.99911285
40	SYK	0.99612952
41	SCYL2	0.97351114
42	OXSR1	0.95589575
43	RPS6KA4	0.94233618
44	PHKG2	0.90867265
45	PHKG1	0.90867265
46	MATK	0.90679850
47	TAOK3	0.83778823
48	DAPK3	0.83466692
49	ERBB3	0.80571629
50	PLK2	0.80306791
51	RPS6KA5	0.79672779
52	MAP3K13	0.79539259
53	WNK3	0.78129715
54	PLK3	0.77386461
55	INSRR	0.75545188
56	DAPK2	0.75381534
57	TRIM28	0.74590464
58	LCK	0.73631617
59	JAK3	0.72512689
60	NLK	0.62641232
61	EIF2AK1	0.61738239
62	CSNK1A1L	0.60904293
63	EPHA3	0.60553019
64	BTK	0.60202600
65	CASK	0.58100417
66	PRKCQ	0.57112051
67	DYRK2	0.56852068
68	TIE1	0.56619429
69	LYN	0.55363677
70	IKBKB	0.53157016
71	MAP4K1	0.51039440
72	TYRO3	0.50138152
73	SRPK1	0.48897894
74	CSNK1A1	0.48511827
75	PRKG1	0.47952459
76	CSNK2A2	0.47363624
77	PRKCI	0.46899853
78	MAPK13	0.46323306
79	OBSCN	0.40840378
80	MKNK2	0.38572517
81	NME1	0.38441006
82	NEK2	0.37162204
83	KDR	0.36466605
84	SGK2	0.35982534
85	PRKCA	0.35519495
86	RIPK4	0.34779991
87	CSNK1E	0.34273750
88	PRKACA	0.33861637
89	ALK	0.33695510
90	CDK7	0.32989640
91	MKNK1	0.32917321
92	RPS6KB1	0.31645373
93	TAF1	0.31314412
94	PRKG2	0.30961305
95	MAP2K6	0.27416266
96	PRKCG	0.27211413
97	BLK	0.26666252
98	ATR	0.24684057
99	PAK4	0.24465859
100	CAMK2D	0.24240956

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	4.36671998
2	Allograft rejection_Homo sapiens_hsa05330	3.80102222
3	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.69841237
4	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.52855759
5	Graft-versus-host disease_Homo sapiens_hsa05332	3.40891907
6	Type I diabetes mellitus_Homo sapiens_hsa04940	3.28590470
7	Proteasome_Homo sapiens_hsa03050	2.86192582
8	Primary immunodeficiency_Homo sapiens_hsa05340	2.78061608
9	Protein export_Homo sapiens_hsa03060	2.76625512
10	Oxidative phosphorylation_Homo sapiens_hsa00190	2.64422038
11	Ribosome_Homo sapiens_hsa03010	2.63444568
12	Parkinsons disease_Homo sapiens_hsa05012	2.35889543
13	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.90518500
14	Basal transcription factors_Homo sapiens_hsa03022	1.73714681
15	Sulfur metabolism_Homo sapiens_hsa00920	1.73377930
16	Antigen processing and presentation_Homo sapiens_hsa04612	1.72816807
17	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.69700062
18	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.68640745
19	Linoleic acid metabolism_Homo sapiens_hsa00591	1.64442551
20	Non-homologous end-joining_Homo sapiens_hsa03450	1.63825449
21	RNA polymerase_Homo sapiens_hsa03020	1.62954603
22	Nitrogen metabolism_Homo sapiens_hsa00910	1.49846513
23	Propanoate metabolism_Homo sapiens_hsa00640	1.44190856
24	Rheumatoid arthritis_Homo sapiens_hsa05323	1.40870227
25	Alzheimers disease_Homo sapiens_hsa05010	1.35842406
26	Huntingtons disease_Homo sapiens_hsa05016	1.35523830
27	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.31655187
28	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.30540938
29	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.28634256
30	Regulation of autophagy_Homo sapiens_hsa04140	1.26593560
31	Cardiac muscle contraction_Homo sapiens_hsa04260	1.26439606
32	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.26169859
33	RNA degradation_Homo sapiens_hsa03018	1.20699108
34	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.13114596
35	Viral myocarditis_Homo sapiens_hsa05416	1.12350828
36	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.07509164
37	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.00391925
38	Homologous recombination_Homo sapiens_hsa03440	1.00240323
39	Caffeine metabolism_Homo sapiens_hsa00232	1.00174175
40	Ether lipid metabolism_Homo sapiens_hsa00565	0.99332202
41	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.98374645
42	Phototransduction_Homo sapiens_hsa04744	0.95792025
43	Nucleotide excision repair_Homo sapiens_hsa03420	0.95221147
44	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.89815670
45	Peroxisome_Homo sapiens_hsa04146	0.86154001
46	Folate biosynthesis_Homo sapiens_hsa00790	0.82860209
47	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.81286524
48	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.79980497
49	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.78956686
50	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.74775404
51	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.67624810
52	Olfactory transduction_Homo sapiens_hsa04740	0.64895185
53	RNA transport_Homo sapiens_hsa03013	0.64783180
54	Tryptophan metabolism_Homo sapiens_hsa00380	0.64474909
55	Pyrimidine metabolism_Homo sapiens_hsa00240	0.64167506
56	Butanoate metabolism_Homo sapiens_hsa00650	0.64166326
57	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.63825049
58	Purine metabolism_Homo sapiens_hsa00230	0.62668571
59	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.61825077
60	Steroid biosynthesis_Homo sapiens_hsa00100	0.60856252
61	Fatty acid degradation_Homo sapiens_hsa00071	0.59694058
62	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.58034635
63	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.56764790
64	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.56407905
65	Leishmaniasis_Homo sapiens_hsa05140	0.55649413
66	Collecting duct acid secretion_Homo sapiens_hsa04966	0.52586062
67	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.51272263
68	Spliceosome_Homo sapiens_hsa03040	0.43994843
69	beta-Alanine metabolism_Homo sapiens_hsa00410	0.43967183
70	Fat digestion and absorption_Homo sapiens_hsa04975	0.43605568
71	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.43434688
72	One carbon pool by folate_Homo sapiens_hsa00670	0.42776779
73	Metabolic pathways_Homo sapiens_hsa01100	0.39764270
74	Chemical carcinogenesis_Homo sapiens_hsa05204	0.38552615
75	Nicotine addiction_Homo sapiens_hsa05033	0.33070327
76	Fanconi anemia pathway_Homo sapiens_hsa03460	0.32774074
77	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.32016238
78	Fatty acid metabolism_Homo sapiens_hsa01212	0.31633629
79	Serotonergic synapse_Homo sapiens_hsa04726	0.30473898
80	Retinol metabolism_Homo sapiens_hsa00830	0.29154708
81	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.28760146
82	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.28692500
83	p53 signaling pathway_Homo sapiens_hsa04115	0.28600285
84	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.28501122
85	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.27202040
86	GABAergic synapse_Homo sapiens_hsa04727	0.27163404
87	Insulin secretion_Homo sapiens_hsa04911	0.25451858
88	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.25143210
89	Amphetamine addiction_Homo sapiens_hsa05031	0.23752652
90	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.23260165
91	Sulfur relay system_Homo sapiens_hsa04122	0.22901450
92	Salivary secretion_Homo sapiens_hsa04970	0.22306693
93	Circadian entrainment_Homo sapiens_hsa04713	0.22029348
94	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.20448888
95	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.20358105
96	Morphine addiction_Homo sapiens_hsa05032	0.19835768
97	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.19586163
98	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.19445888
99	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.18903791
100	Herpes simplex infection_Homo sapiens_hsa05168	0.17213071

NACAP7

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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