NACC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the BTB/POZ protein family. BTB/POZ proteins are involved in several cellular processes including proliferation, apoptosis and transcription regulation. The encoded protein is a transcriptional repressor that plays a role in stem cell self-renewal and pluripotency maintenance. The encoded protein also suppresses transcription of the candidate tumor suppressor Gadd45GIP1, and expression of this gene may play a role in the progression of multiple types of cancer. A pseudogene of this gene is located on the short arm of chromosome 9. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pre-miRNA processing (GO:0031054)5.51428656
2heterochromatin organization (GO:0070828)4.76524933
3nuclear pore complex assembly (GO:0051292)4.69043182
4nuclear pore organization (GO:0006999)4.62515899
5regulation of translational fidelity (GO:0006450)4.60957363
6Golgi transport vesicle coating (GO:0048200)4.50134483
7COPI coating of Golgi vesicle (GO:0048205)4.50134483
8regulation of posttranscriptional gene silencing (GO:0060147)4.43840311
9regulation of gene silencing by miRNA (GO:0060964)4.43840311
10regulation of gene silencing by RNA (GO:0060966)4.43840311
11DNA unwinding involved in DNA replication (GO:0006268)4.40140641
12protein localization to endosome (GO:0036010)4.28191083
13regulation of translational termination (GO:0006449)4.25489920
14protein localization to kinetochore (GO:0034501)4.15221753
15regulation of mammary gland epithelial cell proliferation (GO:0033599)4.15194648
16regulation of early endosome to late endosome transport (GO:2000641)3.89676572
17regulation of hippo signaling (GO:0035330)3.87489260
18folic acid-containing compound biosynthetic process (GO:0009396)3.81535726
19peptidyl-arginine omega-N-methylation (GO:0035247)3.76345106
20protein complex localization (GO:0031503)3.75625740
21peptidyl-lysine dimethylation (GO:0018027)3.70908248
22glucocorticoid receptor signaling pathway (GO:0042921)3.69909335
23proline biosynthetic process (GO:0006561)3.69904044
24activation of Rac GTPase activity (GO:0032863)3.67099574
25protein retention in ER lumen (GO:0006621)3.67024365
26NLS-bearing protein import into nucleus (GO:0006607)3.63648741
27mitotic nuclear envelope disassembly (GO:0007077)3.61967552
28positive regulation of SMAD protein import into nucleus (GO:0060391)3.59861916
29negative regulation of histone methylation (GO:0031061)3.58827620
30maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.57592027
31cellular protein complex localization (GO:0034629)3.51113411
32paraxial mesoderm development (GO:0048339)3.50681900
33membrane disassembly (GO:0030397)3.50415217
34nuclear envelope disassembly (GO:0051081)3.50415217
35mRNA stabilization (GO:0048255)3.48199695
36RNA stabilization (GO:0043489)3.48199695
37chromatin assembly (GO:0031497)3.40674333
38peptidyl-arginine methylation (GO:0018216)3.40436750
39peptidyl-arginine N-methylation (GO:0035246)3.40436750
40establishment of apical/basal cell polarity (GO:0035089)3.35237622
41epithelial cell-cell adhesion (GO:0090136)3.32904990
42retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.31583658
43negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.29829508
44DNA duplex unwinding (GO:0032508)3.29370338
45mitotic G1 DNA damage checkpoint (GO:0031571)3.28896645
46sister chromatid segregation (GO:0000819)3.26761799
47pore complex assembly (GO:0046931)3.26498321
48DNA geometric change (GO:0032392)3.26133967
49polarized epithelial cell differentiation (GO:0030859)3.25277771
50adherens junction assembly (GO:0034333)3.22044853
51semaphorin-plexin signaling pathway (GO:0071526)3.21358025
52intracellular estrogen receptor signaling pathway (GO:0030520)3.20910840
53dosage compensation (GO:0007549)3.20563633
54protein localization to chromosome, centromeric region (GO:0071459)3.19975292
55regulation of RNA export from nucleus (GO:0046831)3.18492475
56pentose-phosphate shunt (GO:0006098)3.17445604
57regulation of glucose import in response to insulin stimulus (GO:2001273)3.17272403
58cytoskeletal anchoring at plasma membrane (GO:0007016)3.17154282
59apoptotic process involved in morphogenesis (GO:0060561)3.13531428
60IMP biosynthetic process (GO:0006188)3.13128291
61spliceosomal tri-snRNP complex assembly (GO:0000244)3.12507947
62negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.11155464
63mitotic sister chromatid segregation (GO:0000070)3.09584612
64regulation of histone H3-K9 methylation (GO:0051570)3.08840651
65mitotic sister chromatid cohesion (GO:0007064)3.08600406
66regulation of SMAD protein import into nucleus (GO:0060390)3.06040119
67regulation of sister chromatid cohesion (GO:0007063)3.04493013
68stress fiber assembly (GO:0043149)3.04040560
69trophectodermal cell differentiation (GO:0001829)3.02399585
70positive regulation of histone deacetylation (GO:0031065)3.01104726
71hippo signaling (GO:0035329)3.00477562
72regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.00077062
73basement membrane organization (GO:0071711)2.99029301
74positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.98360386
75histone H2A monoubiquitination (GO:0035518)2.98017288
76convergent extension (GO:0060026)2.96545719
77DNA replication-dependent nucleosome organization (GO:0034723)2.95428550
78DNA replication-dependent nucleosome assembly (GO:0006335)2.95428550
79corticosteroid receptor signaling pathway (GO:0031958)2.94049222
80skin morphogenesis (GO:0043589)2.92933311
81embryonic process involved in female pregnancy (GO:0060136)2.90646492
82hemidesmosome assembly (GO:0031581)2.90451633
83negative regulation of cell size (GO:0045792)2.89991028
84nuclear envelope organization (GO:0006998)2.87323273
85cell-substrate adherens junction assembly (GO:0007045)2.86058310
86focal adhesion assembly (GO:0048041)2.86058310
87histone arginine methylation (GO:0034969)2.85937487
88negative regulation of mRNA metabolic process (GO:1903312)2.85722188
89mitotic chromosome condensation (GO:0007076)2.85475123
90regulation of NFAT protein import into nucleus (GO:0051532)2.84123099
91positive regulation of chromosome segregation (GO:0051984)2.83942717
92mitotic G1/S transition checkpoint (GO:0044819)2.81557936
93regulation of gene silencing (GO:0060968)2.80983166
94establishment or maintenance of monopolar cell polarity (GO:0061339)2.80375741
95establishment of monopolar cell polarity (GO:0061162)2.80375741
96maternal placenta development (GO:0001893)2.79890613
97dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.79712077
98glucose 6-phosphate metabolic process (GO:0051156)2.79667010
99cytoplasmic mRNA processing body assembly (GO:0033962)2.78600934
100regulation of mitotic spindle organization (GO:0060236)2.77638250
101negative regulation of mRNA processing (GO:0050686)2.76815986
102negative regulation of RNA splicing (GO:0033119)2.76603134
103NADPH regeneration (GO:0006740)2.75781251
104glucose catabolic process (GO:0006007)2.74247015
105histone H4-K12 acetylation (GO:0043983)2.72771620
106positive regulation of RNA splicing (GO:0033120)2.72000549
107positive regulation of Cdc42 GTPase activity (GO:0043089)2.71975401
1083-UTR-mediated mRNA stabilization (GO:0070935)2.71599543
109barbed-end actin filament capping (GO:0051016)2.71287565
110IMP metabolic process (GO:0046040)2.69917881
111positive regulation of gene expression, epigenetic (GO:0045815)2.69745215
112nodal signaling pathway (GO:0038092)2.69118692
113regulation of nucleobase-containing compound transport (GO:0032239)2.69116248
114gene silencing (GO:0016458)2.68322635
115anterior/posterior axis specification, embryo (GO:0008595)2.68297509
116pinocytosis (GO:0006907)2.67657994
117response to UV-C (GO:0010225)2.67055550
118epithelial cell differentiation involved in prostate gland development (GO:0060742)2.66647394
119modulation by symbiont of host cellular process (GO:0044068)2.66117992
120G1 DNA damage checkpoint (GO:0044783)2.65645997
121positive regulation of blood vessel endothelial cell migration (GO:0043536)2.64291856
122planar cell polarity pathway involved in neural tube closure (GO:0090179)2.63756855
123regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.62446243
124gene silencing by RNA (GO:0031047)2.61835992
125regulation of spindle organization (GO:0090224)2.60582844
126activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.59827190
127regulation of mRNA stability (GO:0043488)2.59461546
128cell-substrate junction assembly (GO:0007044)2.59246841
129Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.58731939
130nucleosome disassembly (GO:0006337)2.58284315
131protein-DNA complex disassembly (GO:0032986)2.58284315
132establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.58260461
133regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.58112779
134protein export from nucleus (GO:0006611)2.57960155
135branching involved in mammary gland duct morphogenesis (GO:0060444)2.57558161
136chromatin silencing (GO:0006342)2.57390808
137cellular response to epidermal growth factor stimulus (GO:0071364)2.57285684
138negative regulation of DNA repair (GO:0045738)2.57277145
139protein maturation by protein folding (GO:0022417)2.55270121
140modulation by virus of host morphology or physiology (GO:0019048)2.55102010
141positive regulation of nuclease activity (GO:0032075)2.53145194
142desmosome organization (GO:0002934)2.52903848
143negative regulation of fatty acid transport (GO:2000192)2.51337382
144protein localization to microtubule (GO:0035372)2.47608555
145regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.45666912
146cell-cell junction maintenance (GO:0045217)2.44557400
147regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.43868946
148modulation by virus of host process (GO:0019054)2.43436490
149regulation of establishment of planar polarity (GO:0090175)2.41498572
150vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.39696965
151endoplasmic reticulum unfolded protein response (GO:0030968)2.37822613
152proline metabolic process (GO:0006560)2.36777408
153regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.36639529
154positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.36639529
155actin filament bundle organization (GO:0061572)2.36440990
156actin filament bundle assembly (GO:0051017)2.36440990
157negative regulation of cell fate specification (GO:0009996)2.35269497
158embryonic eye morphogenesis (GO:0048048)2.35157359
159regulation of chromatin binding (GO:0035561)2.33896213
160activation of MAPKKK activity (GO:0000185)2.33623399
161negative regulation of erythrocyte differentiation (GO:0045647)2.32525120
162regulation of cholesterol homeostasis (GO:2000188)2.32269069
163ER-nucleus signaling pathway (GO:0006984)2.31863088
164regulation of extracellular matrix disassembly (GO:0010715)2.31729866

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.64763851
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.57127366
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.75935264
4MYC_22102868_ChIP-Seq_BL_Human3.45546629
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.44618611
6ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.46185359
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.31634199
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.31221054
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.14723849
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.14342709
11KDM2B_26808549_Chip-Seq_DND41_Human2.13524371
12ZFP281_18757296_ChIP-ChIP_E14_Mouse2.12497006
13VDR_21846776_ChIP-Seq_THP-1_Human2.11818068
14SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.07731160
15TCF7_22412390_ChIP-Seq_EML_Mouse2.06646984
16TP63_17297297_ChIP-ChIP_HaCaT_Human2.05903836
17MYC_18555785_ChIP-Seq_MESCs_Mouse2.03058582
18POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.01899728
19KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.00853491
20SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.99890311
21* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.99681963
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.99653619
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.95675944
24ZFP281_27345836_Chip-Seq_ESCs_Mouse1.92357617
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.91303699
26KDM2B_26808549_Chip-Seq_SUP-B15_Human1.89525346
27ESR1_15608294_ChIP-ChIP_MCF-7_Human1.88091389
28ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.87232625
29EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.86176617
30ELK3_25401928_ChIP-Seq_HUVEC_Human1.85487584
31KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.85163626
32ZNF263_19887448_ChIP-Seq_K562_Human1.77208672
33SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.76355418
34TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69896302
35HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.68855608
36* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.67359389
37ESR2_21235772_ChIP-Seq_MCF-7_Human1.61971619
38KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.61155025
39KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.60791815
40KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.60791815
41KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.60791815
42NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.60578173
43STAT6_21828071_ChIP-Seq_BEAS2B_Human1.59940458
44MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.59089917
45STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.57533788
46AR_21909140_ChIP-Seq_LNCAP_Human1.54587376
47TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.54385961
48STAT3_1855785_ChIP-Seq_MESCs_Mouse1.53978612
49P300_27058665_Chip-Seq_ZR-75-30cells_Human1.53034551
50ERG_21242973_ChIP-ChIP_JURKAT_Human1.50559827
51RACK7_27058665_Chip-Seq_MCF-7_Human1.49663560
52E2F1_21310950_ChIP-Seq_MCF-7_Human1.49377439
53LXR_22292898_ChIP-Seq_THP-1_Human1.46955980
54CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.46832287
55KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.46483637
56ATF3_27146783_Chip-Seq_COLON_Human1.45788533
57TCF3_18692474_ChIP-Seq_MEFs_Mouse1.45596226
58PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.43968857
59DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.43806588
60KDM2B_26808549_Chip-Seq_JURKAT_Human1.43004632
61TET1_21451524_ChIP-Seq_MESCs_Mouse1.40972301
62TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.39167365
63WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.38804100
64KLF4_18555785_ChIP-Seq_MESCs_Mouse1.35120327
65SRY_22984422_ChIP-ChIP_TESTIS_Rat1.34717854
66RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.33986919
67KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.32847134
68HIF1A_21447827_ChIP-Seq_MCF-7_Human1.32566115
69KDM2B_26808549_Chip-Seq_K562_Human1.31797383
70DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.31059181
71CLOCK_20551151_ChIP-Seq_293T_Human1.29840260
72UTX_26944678_Chip-Seq_JUKART_Human1.28906964
73NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.28446478
74MAF_26560356_Chip-Seq_TH1_Human1.25212189
75NCOR1_26117541_ChIP-Seq_K562_Human1.25039686
76NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.24163785
77NANOG_18555785_ChIP-Seq_MESCs_Mouse1.24004786
78CTCF_27219007_Chip-Seq_ERYTHROID_Human1.23896261
79NANOG_21062744_ChIP-ChIP_HESCs_Human1.22107944
80CIITA_25753668_ChIP-Seq_RAJI_Human1.21841112
81XRN2_22483619_ChIP-Seq_HELA_Human1.21182346
82NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.20612512
83* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.20397262
84MYC_18358816_ChIP-ChIP_MESCs_Mouse1.19003694
85SA1_27219007_Chip-Seq_ERYTHROID_Human1.18024672
86SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.17989602
87CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17885376
88CREB1_26743006_Chip-Seq_LNCaP_Human1.16944562
89TCF3_18692474_ChIP-Seq_MESCs_Mouse1.16858542
90HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.14926424
91SMC4_20622854_ChIP-Seq_HELA_Human1.14442349
92* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.12484576
93TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.12316550
94TP53_22127205_ChIP-Seq_IMR90_Human1.12007525
95TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10880727
96CHD1_26751641_Chip-Seq_LNCaP_Human1.10857762
97CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.08758338
98NELFA_20434984_ChIP-Seq_ESCs_Mouse1.08521777
99UBF1/2_26484160_Chip-Seq_HMECs_Human1.08351457
100SALL1_21062744_ChIP-ChIP_HESCs_Human1.08177630
101VDR_24763502_ChIP-Seq_THP-1_Human1.07274346
102SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.07227660
103SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.07016892
104SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06932224
105ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.06823656
106KDM5A_27292631_Chip-Seq_BREAST_Human1.05924887
107POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.05617678
108EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.05253477
109TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03889938
110CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.03166707
111MYCN_18555785_ChIP-Seq_MESCs_Mouse1.03004745
112* SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.01451361
113RUNX1_27514584_Chip-Seq_MCF-7_Human1.01229058
114UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.00699821
115PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.99807158
116BRD4_27068464_Chip-Seq_AML-cells_Mouse0.99641027
117ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.98039474
118ZFX_18555785_ChIP-Seq_MESCs_Mouse0.97414699
119ESR1_21235772_ChIP-Seq_MCF-7_Human0.97369216
120TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97193971
121EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.97061045
122ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.96848079
123SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.95797944
124CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95632130
125GATA1_22383799_ChIP-Seq_G1ME_Mouse0.95594262
126PKCTHETA_26484144_Chip-Seq_BREAST_Human0.95543422
127ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.95475460
128P68_20966046_ChIP-Seq_HELA_Human0.95206177
129SOX2_18555785_ChIP-Seq_MESCs_Mouse0.94269064
130GATA6_25053715_ChIP-Seq_YYC3_Human0.93960885
131FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.93043163
132OCT4_18692474_ChIP-Seq_MEFs_Mouse0.92137461
133FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.92117359

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.29986967
2MP0010352_gastrointestinal_tract_polyps3.76198310
3MP0005076_abnormal_cell_differentiation3.33720920
4MP0005451_abnormal_body_composition2.69088415
5MP0010234_abnormal_vibrissa_follicle2.56264539
6MP0003111_abnormal_nucleus_morphology2.50508974
7MP0005257_abnormal_intraocular_pressure2.44145642
8MP0001730_embryonic_growth_arrest2.33798372
9MP0004957_abnormal_blastocyst_morpholog2.33134761
10MP0003566_abnormal_cell_adhesion2.32124136
11MP0010307_abnormal_tumor_latency2.22543418
12MP0001849_ear_inflammation2.18019139
13MP0003283_abnormal_digestive_organ2.15743821
14MP0000537_abnormal_urethra_morphology2.15514573
15MP0005623_abnormal_meninges_morphology2.13019171
16MP0004197_abnormal_fetal_growth/weight/2.11377746
17MP0010094_abnormal_chromosome_stability2.10017585
18MP0003123_paternal_imprinting2.10007036
19MP0003077_abnormal_cell_cycle2.07694052
20MP0002084_abnormal_developmental_patter2.04853767
21MP0009278_abnormal_bone_marrow2.04355044
22MP0002796_impaired_skin_barrier2.04056349
23MP0000350_abnormal_cell_proliferation1.96083918
24MP0005058_abnormal_lysosome_morphology1.95105509
25MP0010030_abnormal_orbit_morphology1.93407314
26MP0002254_reproductive_system_inflammat1.91331758
27MP0005380_embryogenesis_phenotype1.88131556
28MP0001672_abnormal_embryogenesis/_devel1.88131556
29MP0003300_gastrointestinal_ulcer1.84865614
30MP0002086_abnormal_extraembryonic_tissu1.84620192
31MP0002085_abnormal_embryonic_tissue1.82540993
32MP0003984_embryonic_growth_retardation1.81020783
33MP0000733_abnormal_muscle_development1.79856390
34MP0002088_abnormal_embryonic_growth/wei1.78867233
35MP0002653_abnormal_ependyma_morphology1.77601503
36MP0003693_abnormal_embryo_hatching1.76207435
37MP0001697_abnormal_embryo_size1.75208434
38MP0009053_abnormal_anal_canal1.67571817
39MP0002877_abnormal_melanocyte_morpholog1.67554172
40MP0005501_abnormal_skin_physiology1.65078090
41MP0004185_abnormal_adipocyte_glucose1.63867114
42MP0009840_abnormal_foam_cell1.61592088
43MP0005409_darkened_coat_color1.57573839
44MP0003119_abnormal_digestive_system1.55401978
45MP0002080_prenatal_lethality1.54669308
46MP0004233_abnormal_muscle_weight1.53724635
47MP0000678_abnormal_parathyroid_gland1.52034671
48MP0008260_abnormal_autophagy1.50184117
49MP0008961_abnormal_basal_metabolism1.46162786
50MP0003890_abnormal_embryonic-extraembry1.45258977
51MP0005023_abnormal_wound_healing1.40790244
52MP0003303_peritoneal_inflammation1.37354798
53MP0002060_abnormal_skin_morphology1.35943570
54MP0004808_abnormal_hematopoietic_stem1.34385202
55MP0000579_abnormal_nail_morphology1.33132769
56MP0000858_altered_metastatic_potential1.33049940
57MP0003115_abnormal_respiratory_system1.31885682
58MP0000428_abnormal_craniofacial_morphol1.30558097
59MP0008057_abnormal_DNA_replication1.27334925
60MP0009672_abnormal_birth_weight1.26832905
61MP0003091_abnormal_cell_migration1.25455290
62MP0004858_abnormal_nervous_system1.25343322
63MP0002925_abnormal_cardiovascular_devel1.24995897
64MP0008007_abnormal_cellular_replicative1.22587322
65MP0001915_intracranial_hemorrhage1.20352560
66MP0001293_anophthalmia1.20239672
67MP0009703_decreased_birth_body1.19467576
68MP0003567_abnormal_fetal_cardiomyocyte1.19431104
69MP0002396_abnormal_hematopoietic_system1.17863199
70MP0003121_genomic_imprinting1.16703234
71MP0002249_abnormal_larynx_morphology1.16341456
72MP0008770_decreased_survivor_rate1.12318278
73MP0004264_abnormal_extraembryonic_tissu1.10880170
74MP0003329_amyloid_beta_deposits1.10198810
75MP0000534_abnormal_ureter_morphology1.09630901
76MP0000566_synostosis1.08449687
77MP0002697_abnormal_eye_size1.07802574
78MP0010630_abnormal_cardiac_muscle1.07064372
79MP0003191_abnormal_cellular_cholesterol1.04149256
80MP0004947_skin_inflammation1.03871184
81MP0003935_abnormal_craniofacial_develop1.02968624
82MP0002092_abnormal_eye_morphology1.02256868
83MP0001216_abnormal_epidermal_layer1.00955915
84MP0002089_abnormal_postnatal_growth/wei1.00824492
85MP0002111_abnormal_tail_morphology0.99869705
86MP0000762_abnormal_tongue_morphology0.99389817
87MP0001545_abnormal_hematopoietic_system0.97655077
88MP0005397_hematopoietic_system_phenotyp0.97655077
89MP0000767_abnormal_smooth_muscle0.96562803
90MP0003279_aneurysm0.95716636
91MP0000266_abnormal_heart_morphology0.92797370
92MP0008932_abnormal_embryonic_tissue0.92192998
93MP0000751_myopathy0.91636419
94MP0000467_abnormal_esophagus_morphology0.91555017
95MP0003861_abnormal_nervous_system0.91442099
96MP0003385_abnormal_body_wall0.90056065
97MP0001348_abnormal_lacrimal_gland0.88726793
98MP0000569_abnormal_digit_pigmentation0.88279785
99MP0000432_abnormal_head_morphology0.88109434
100MP0003172_abnormal_lysosome_physiology0.88088204
101MP0000490_abnormal_crypts_of0.87973553
102MP0005666_abnormal_adipose_tissue0.87271732
103MP0005621_abnormal_cell_physiology0.86900655
104MP0005187_abnormal_penis_morphology0.86828201
105MP0000313_abnormal_cell_death0.86774764
106MP0004087_abnormal_muscle_fiber0.85523452
107MP0000462_abnormal_digestive_system0.83183641
108MP0002896_abnormal_bone_mineralization0.82648993
109MP0002098_abnormal_vibrissa_morphology0.82318957
110MP0002019_abnormal_tumor_incidence0.82298240
111MP0000747_muscle_weakness0.82070129
112MP0005375_adipose_tissue_phenotype0.79783503
113MP0000750_abnormal_muscle_regeneration0.79597839
114MP0002932_abnormal_joint_morphology0.79585659
115MP0003942_abnormal_urinary_system0.78003372
116MP0009931_abnormal_skin_appearance0.77889606
117MP0000759_abnormal_skeletal_muscle0.77813830
118MP0001346_abnormal_lacrimal_gland0.77808364
119MP0001784_abnormal_fluid_regulation0.77760696
120MP0009384_cardiac_valve_regurgitation0.77533385
121MP0004510_myositis0.77049615
122MP0000703_abnormal_thymus_morphology0.76767744
123MP0000003_abnormal_adipose_tissue0.76507660
124MP0003453_abnormal_keratinocyte_physiol0.74183888
125MP0000477_abnormal_intestine_morphology0.74098819
126MP0000377_abnormal_hair_follicle0.73755924
127MP0005508_abnormal_skeleton_morphology0.73390894
128MP0002269_muscular_atrophy0.72481778
129MP0004272_abnormal_basement_membrane0.71957504
130MP0005377_hearing/vestibular/ear_phenot0.71722823
131MP0003878_abnormal_ear_physiology0.71722823
132MP0005384_cellular_phenotype0.71159191
133MP0002234_abnormal_pharynx_morphology0.69858404
134MP0004133_heterotaxia0.69455291
135MP0001614_abnormal_blood_vessel0.67682344
136MP0008438_abnormal_cutaneous_collagen0.67469915
137MP0003941_abnormal_skin_development0.66988327

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)3.79261064
2Premature rupture of membranes (HP:0001788)3.72700128
3Hyperacusis (HP:0010780)3.34092069
4Astrocytoma (HP:0009592)3.32060190
5Abnormality of the astrocytes (HP:0100707)3.32060190
6Shallow orbits (HP:0000586)3.01878996
7Short 4th metacarpal (HP:0010044)2.93139877
8Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.93139877
9Cerebral aneurysm (HP:0004944)2.90404734
10Upper limb amyotrophy (HP:0009129)2.73773667
11Distal upper limb amyotrophy (HP:0007149)2.73773667
12Distal lower limb amyotrophy (HP:0008944)2.72827696
13Renal duplication (HP:0000075)2.69527060
14Abnormality of the lower motor neuron (HP:0002366)2.69135091
15Broad face (HP:0000283)2.65147713
16Long palpebral fissure (HP:0000637)2.64477604
17Vertebral compression fractures (HP:0002953)2.63927490
18Disproportionate tall stature (HP:0001519)2.62726733
19Hand muscle atrophy (HP:0009130)2.60413220
20Asymmetry of the thorax (HP:0001555)2.56852107
21Protrusio acetabuli (HP:0003179)2.53377563
22Pseudobulbar signs (HP:0002200)2.51896406
23Increased nuchal translucency (HP:0010880)2.51067023
24Distal lower limb muscle weakness (HP:0009053)2.48211155
25Selective tooth agenesis (HP:0001592)2.47356968
26Deviation of the thumb (HP:0009603)2.38184442
27Obstructive sleep apnea (HP:0002870)2.37039699
28Glioma (HP:0009733)2.36904937
29Elfin facies (HP:0004428)2.36718081
30Ulnar bowing (HP:0003031)2.36150471
31Flat acetabular roof (HP:0003180)2.35249230
32Pointed chin (HP:0000307)2.33110393
33Abnormality of the 4th metacarpal (HP:0010012)2.30201156
34Malignant gastrointestinal tract tumors (HP:0006749)2.29382936
35Gastrointestinal carcinoma (HP:0002672)2.29382936
36Spinal rigidity (HP:0003306)2.28517238
37Neoplasm of the oral cavity (HP:0100649)2.26882068
38Proximal placement of thumb (HP:0009623)2.26179146
39Fragile skin (HP:0001030)2.25790561
40Arnold-Chiari malformation (HP:0002308)2.24442072
41Lower limb amyotrophy (HP:0007210)2.23876959
42Renovascular hypertension (HP:0100817)2.23545074
43Genu recurvatum (HP:0002816)2.23532484
44Ankle contracture (HP:0006466)2.21896971
45Turricephaly (HP:0000262)2.20889326
46Centrally nucleated skeletal muscle fibers (HP:0003687)2.19896830
47Bowel diverticulosis (HP:0005222)2.19893356
48Medulloblastoma (HP:0002885)2.18464251
49Fibroma (HP:0010614)2.16068936
50Insomnia (HP:0100785)2.15434425
51Neoplasm of striated muscle (HP:0009728)2.12505480
52Heterotopia (HP:0002282)2.11931254
53Macroorchidism (HP:0000053)2.10905604
54Increased density of long bones (HP:0006392)2.10797831
55Broad thumb (HP:0011304)2.10643761
56Basal cell carcinoma (HP:0002671)2.10535645
57Advanced eruption of teeth (HP:0006288)2.09354791
58Fibrous tissue neoplasm (HP:0012316)2.08228799
59Short nail (HP:0001799)2.07900895
60Natal tooth (HP:0000695)2.06894637
61Rectal prolapse (HP:0002035)2.06168340
62Trismus (HP:0000211)2.05122074
63Mitral regurgitation (HP:0001653)2.04352105
64Blue sclerae (HP:0000592)2.03279118
65Subacute progressive viral hepatitis (HP:0006572)2.03098349
66Cervical subluxation (HP:0003308)2.02973853
67Dysmetric saccades (HP:0000641)2.01428388
68Urethral obstruction (HP:0000796)2.01240877
69Syringomyelia (HP:0003396)2.01204375
70Spinal cord lesions (HP:0100561)2.01204375
71Ankyloglossia (HP:0010296)2.00515827
72Thin bony cortex (HP:0002753)2.00294189
73Missing ribs (HP:0000921)2.00122766
74Overriding aorta (HP:0002623)1.99472192
75Colon cancer (HP:0003003)1.98272684
76Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.97678642
77Broad palm (HP:0001169)1.97380054
78Annular pancreas (HP:0001734)1.97097413
79Enlarged penis (HP:0000040)1.96352875
80Rhabdomyosarcoma (HP:0002859)1.96014168
81Biliary tract neoplasm (HP:0100574)1.94843311
82Patellar dislocation (HP:0002999)1.94336008
83Adenoma sebaceum (HP:0009720)1.93131781
84Angiofibromas (HP:0010615)1.93131781
85Abnormality of the distal phalanges of the toes (HP:0010182)1.91690929
86Biconcave vertebral bodies (HP:0004586)1.91321934
87Trigonocephaly (HP:0000243)1.90247012
88Long eyelashes (HP:0000527)1.90171644
89Skin tags (HP:0010609)1.89253889
90Generalized amyotrophy (HP:0003700)1.89128802
91Achilles tendon contracture (HP:0001771)1.88700641
92Short humerus (HP:0005792)1.87560197
93Cerebral inclusion bodies (HP:0100314)1.87411620
94High pitched voice (HP:0001620)1.87191992
95Abnormality of the thoracic spine (HP:0100711)1.87060162
96Atrophic scars (HP:0001075)1.85086691
97Skull defect (HP:0001362)1.84942609
98Back pain (HP:0003418)1.84677511
99Mitral valve prolapse (HP:0001634)1.84514506
100Elbow flexion contracture (HP:0002987)1.84029144
101Abnormality of oral frenula (HP:0000190)1.83538855
102Aneurysm (HP:0002617)1.83495984
103Short phalanx of the thumb (HP:0009660)1.83385716
104Bladder diverticulum (HP:0000015)1.82575717
105Hyperparathyroidism (HP:0000843)1.82127926
106Broad distal phalanx of finger (HP:0009836)1.82049030
107Osteolytic defects of the hand bones (HP:0009699)1.79806596
108Osteolytic defects of the phalanges of the hand (HP:0009771)1.79806596
109Spastic diplegia (HP:0001264)1.79599332
110Stridor (HP:0010307)1.79141116
111Bronchomalacia (HP:0002780)1.78619965
112Lymphangioma (HP:0100764)1.77343950
113Mildly elevated creatine phosphokinase (HP:0008180)1.77138574
114Bowing of the arm (HP:0006488)1.76918768
115Bowed forearm bones (HP:0003956)1.76918768
116Progressive muscle weakness (HP:0003323)1.74680499
117Increased variability in muscle fiber diameter (HP:0003557)1.74142507
118Sandal gap (HP:0001852)1.73798163
119Supernumerary ribs (HP:0005815)1.73557312
120Rib fusion (HP:0000902)1.72024078
121Abnormality of the diencephalon (HP:0010662)1.71684076
122Abnormality of the fingertips (HP:0001211)1.71620123
123Abnormal ossification of hand bones (HP:0005921)1.71503054
124Premature skin wrinkling (HP:0100678)1.71391891
125Wormian bones (HP:0002645)1.71200748
126Resting tremor (HP:0002322)1.71099099
127Increased connective tissue (HP:0009025)1.70462668
128Obsessive-compulsive behavior (HP:0000722)1.70248429
129Spinal cord compression (HP:0002176)1.70057151
130Deviation of the hallux (HP:0010051)1.69331145
131Abnormality of the labia minora (HP:0012880)1.68659506
132Broad metatarsal (HP:0001783)1.68137260
133Radial bowing (HP:0002986)1.67094036
134Hallux valgus (HP:0001822)1.66864802
135Abnormality of the Achilles tendon (HP:0005109)1.66534828
136Aplasia/hypoplasia of the humerus (HP:0006507)1.66439560
137Volvulus (HP:0002580)1.66144000
138Leiomyosarcoma (HP:0100243)1.65635481
139Uterine leiomyosarcoma (HP:0002891)1.65635481
140Neoplasm of the heart (HP:0100544)1.65421961
141Thin ribs (HP:0000883)1.65245264
142Flat cornea (HP:0007720)1.65079133
143Metaphyseal cupping (HP:0003021)1.64515890
144Vertebral clefting (HP:0008428)1.64365542
145Congenital glaucoma (HP:0001087)1.64189830
146Uterine neoplasm (HP:0010784)1.63924567
147Vertebral arch anomaly (HP:0008438)1.63871282
148Abnormality of the distal phalanx of the thumb (HP:0009617)1.63656324
149Preauricular skin tag (HP:0000384)1.63151753
150Dilatation of the ascending aorta (HP:0005111)1.63121695
151Difficulty climbing stairs (HP:0003551)1.62761376
152Broad phalanges of the hand (HP:0009768)1.62694250
153Vertebral fusion (HP:0002948)1.62123793
154Abnormality of skeletal muscle fiber size (HP:0012084)1.59681644
155Abnormality of dentin (HP:0010299)1.57697760
156Midface retrusion (HP:0011800)1.57477424
157Abnormality of the umbilical cord (HP:0010881)1.56549772
158Polygenic inheritance (HP:0010982)1.55897090
159Arterial tortuosity (HP:0005116)1.54706111
160Hypercalcemia (HP:0003072)1.54611753
161Upper motor neuron abnormality (HP:0002127)1.54337394
162Hyperextensible skin (HP:0000974)1.54042578
163Aplasia involving bones of the extremities (HP:0009825)1.52995706
164Aplasia involving bones of the upper limbs (HP:0009823)1.52995706
165Aplasia of the phalanges of the hand (HP:0009802)1.52995706
166Choanal stenosis (HP:0000452)1.51272606
167Long toe (HP:0010511)1.50988164
168Sparse lateral eyebrow (HP:0005338)1.50698177

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.22675538
2SMG14.18552307
3EEF2K4.15373468
4TRIB33.80346941
5PKN23.62945868
6IRAK33.00531254
7MAP3K102.93335445
8PRPF4B2.70227140
9CDC72.30997100
10NME22.28246123
11ICK2.07439340
12NEK12.05407186
13ALK1.97618174
14NEK21.96653898
15RIPK11.93988438
16TTN1.88949546
17BMX1.79684145
18PDGFRA1.73031306
19FGFR41.72370145
20SCYL21.70756041
21PTK61.66745240
22LATS11.63213623
23LATS21.61503060
24EPHA21.56124283
25RPS6KB21.54994968
26MTOR1.49428951
27PRKD31.46161064
28PAK41.45285443
29TAOK21.37091797
30TYRO31.36599470
31STK101.30123055
32BRD41.29990879
33LRRK21.29443085
34MST1R1.28717963
35CDK41.27349802
36ARAF1.25378164
37NTRK11.24704815
38MAP3K81.23154240
39CDK61.22824888
40KSR21.19217495
41PASK1.15221685
42SIK11.13541187
43ERN11.13199385
44CAMK1D1.12793979
45TTK1.12557243
46TSSK61.06719068
47PAK21.06095578
48DDR21.03733280
49CAMK1G1.00906078
50TAOK11.00611489
51MAP3K90.97109886
52CDK70.94913246
53DMPK0.92250700
54FGFR10.91763611
55BRAF0.91598090
56FLT30.89690121
57PTK20.87372414
58CHEK10.87273293
59MAP3K130.86181310
60PAK60.84830625
61SIK20.84693380
62PRKD20.80526312
63TESK20.79102264
64IRAK20.78147751
65STK30.77832047
66RET0.75243132
67PDPK10.74358194
68GRK60.73999664
69CDK20.72658439
70PRKG20.69671014
71MAP3K110.68876123
72MET0.68303770
73PDGFRB0.67651540
74WEE10.65760923
75ERBB40.65213001
76ATR0.64746727
77MAP4K10.63665675
78AKT20.63651199
79BUB10.63446280
80MAP2K20.61894538
81MAP3K70.61372343
82MOS0.60771293
83MAP3K10.60110344
84KSR10.59091490
85RPS6KL10.58985736
86RPS6KC10.58985736
87CAMKK10.58435831
88LIMK10.58313150
89TGFBR10.57704724
90PLK10.55885572
91MAP3K30.55275694
92AURKB0.54109292
93ILK0.52743748
94TESK10.52636230
95RPS6KA40.52500859
96ATM0.52101215
97MAPK110.51942816
98AURKA0.51157182
99RPS6KA10.50201078
100CSNK1E0.50027177
101STK380.49192530
102HIPK20.47540788
103CHEK20.46228770
104PAK10.44154114
105PIM10.43590051
106CDK10.43579587
107PRKCH0.42538388
108STK40.42233921
109MAP3K20.41954550
110TAF10.41058236
111VRK20.40263624
112IRAK40.40061215
113CDK11A0.39211290
114CDK150.39066774
115CDK80.38978393
116PRKDC0.38752054
117CDC42BPA0.38724686
118MAPK10.38366314
119MAPK140.38043138
120* CSNK1D0.37176577
121CDK90.36902262
122PIM20.36502523
123LMTK20.36480995
124MELK0.35651541
125RPS6KA20.35359819
126STK110.34958404
127MAP2K30.34570135
128KDR0.34117540
129CDK180.34059505
130SIK30.34027024
131BRSK10.33933791
132FGFR30.33767508
133ROCK20.33457509
134RPS6KA60.32976996
135EPHB20.32818019
136PNCK0.32213351
137MARK20.31891061
138* GSK3B0.30860696
139AKT10.30692840
140EPHB10.29660494
141ERBB20.29464295

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.12074411
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.05543689
3Chronic myeloid leukemia_Homo sapiens_hsa052201.88270591
4One carbon pool by folate_Homo sapiens_hsa006701.85733359
5mTOR signaling pathway_Homo sapiens_hsa041501.85298449
6RNA transport_Homo sapiens_hsa030131.77002751
7Pentose phosphate pathway_Homo sapiens_hsa000301.66264267
8Adherens junction_Homo sapiens_hsa045201.65437516
9mRNA surveillance pathway_Homo sapiens_hsa030151.64723537
10Nitrogen metabolism_Homo sapiens_hsa009101.61971834
11Central carbon metabolism in cancer_Homo sapiens_hsa052301.61155224
12MicroRNAs in cancer_Homo sapiens_hsa052061.60791138
13DNA replication_Homo sapiens_hsa030301.57524651
14Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.56053714
15Prion diseases_Homo sapiens_hsa050201.55720122
16Hippo signaling pathway_Homo sapiens_hsa043901.52975590
17Cell cycle_Homo sapiens_hsa041101.50654394
18Proteoglycans in cancer_Homo sapiens_hsa052051.48920511
19Notch signaling pathway_Homo sapiens_hsa043301.46151676
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.44555605
21Lysine degradation_Homo sapiens_hsa003101.44434378
22Other glycan degradation_Homo sapiens_hsa005111.44000479
23Endometrial cancer_Homo sapiens_hsa052131.41843007
24Non-small cell lung cancer_Homo sapiens_hsa052231.41682720
25Bladder cancer_Homo sapiens_hsa052191.40954233
26Mismatch repair_Homo sapiens_hsa034301.40630437
27Basal cell carcinoma_Homo sapiens_hsa052171.40252194
28Colorectal cancer_Homo sapiens_hsa052101.39901839
29Small cell lung cancer_Homo sapiens_hsa052221.37352299
30Glioma_Homo sapiens_hsa052141.34751982
31Thyroid hormone signaling pathway_Homo sapiens_hsa049191.34211412
32Thyroid cancer_Homo sapiens_hsa052161.33558138
33Spliceosome_Homo sapiens_hsa030401.32886411
34Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.30969297
35Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.28630912
36Neurotrophin signaling pathway_Homo sapiens_hsa047221.26513728
37Fructose and mannose metabolism_Homo sapiens_hsa000511.24398439
38Vitamin B6 metabolism_Homo sapiens_hsa007501.24004837
39Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.22843664
40Focal adhesion_Homo sapiens_hsa045101.20821958
41Galactose metabolism_Homo sapiens_hsa000521.19223241
42Viral carcinogenesis_Homo sapiens_hsa052031.19188755
43HTLV-I infection_Homo sapiens_hsa051661.14486830
44Acute myeloid leukemia_Homo sapiens_hsa052211.14391820
45VEGF signaling pathway_Homo sapiens_hsa043701.12088799
46Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.11331320
47Biosynthesis of amino acids_Homo sapiens_hsa012301.07263055
48Hedgehog signaling pathway_Homo sapiens_hsa043401.07077774
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.06570377
50Estrogen signaling pathway_Homo sapiens_hsa049151.03749837
51Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.03172387
52Viral myocarditis_Homo sapiens_hsa054161.02970020
53Tight junction_Homo sapiens_hsa045301.02778902
54Oocyte meiosis_Homo sapiens_hsa041141.02564471
55Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.01058208
56Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.00579986
57Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.00187064
58Dorso-ventral axis formation_Homo sapiens_hsa043200.99923542
59Pancreatic cancer_Homo sapiens_hsa052120.98463974
60Renal cell carcinoma_Homo sapiens_hsa052110.98121715
61AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.95473578
62Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.95321887
63HIF-1 signaling pathway_Homo sapiens_hsa040660.93999228
64Leukocyte transendothelial migration_Homo sapiens_hsa046700.90654940
65p53 signaling pathway_Homo sapiens_hsa041150.89996963
66TGF-beta signaling pathway_Homo sapiens_hsa043500.89881015
67Regulation of actin cytoskeleton_Homo sapiens_hsa048100.88789266
68Vibrio cholerae infection_Homo sapiens_hsa051100.87223892
69Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.86126449
70Insulin resistance_Homo sapiens_hsa049310.85991037
71Hepatitis C_Homo sapiens_hsa051600.85695239
72Sulfur relay system_Homo sapiens_hsa041220.84546645
73Pathways in cancer_Homo sapiens_hsa052000.84207152
74Longevity regulating pathway - mammal_Homo sapiens_hsa042110.82943100
75Insulin signaling pathway_Homo sapiens_hsa049100.82087838
76GnRH signaling pathway_Homo sapiens_hsa049120.81680837
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.80794076
78ErbB signaling pathway_Homo sapiens_hsa040120.80715809
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.80564359
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.79693763
81AMPK signaling pathway_Homo sapiens_hsa041520.78600375
82Amoebiasis_Homo sapiens_hsa051460.78024988
83Base excision repair_Homo sapiens_hsa034100.77059197
84Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.76472178
85Prostate cancer_Homo sapiens_hsa052150.76198538
86Wnt signaling pathway_Homo sapiens_hsa043100.75418005
87Rap1 signaling pathway_Homo sapiens_hsa040150.75127633
88Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74485730
89Transcriptional misregulation in cancer_Homo sapiens_hsa052020.72829313
90Carbon metabolism_Homo sapiens_hsa012000.72826990
91B cell receptor signaling pathway_Homo sapiens_hsa046620.72204156
92Glycosaminoglycan degradation_Homo sapiens_hsa005310.71706416
93Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.71557055
94Type II diabetes mellitus_Homo sapiens_hsa049300.71180267
95ECM-receptor interaction_Homo sapiens_hsa045120.69922708
96Salmonella infection_Homo sapiens_hsa051320.69324029
97Hepatitis B_Homo sapiens_hsa051610.69159969
98Choline metabolism in cancer_Homo sapiens_hsa052310.67643809
99Antigen processing and presentation_Homo sapiens_hsa046120.67166143
100Inositol phosphate metabolism_Homo sapiens_hsa005620.66891056
101Melanogenesis_Homo sapiens_hsa049160.66372033
102Melanoma_Homo sapiens_hsa052180.66343535
103Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.65591086
104Prolactin signaling pathway_Homo sapiens_hsa049170.65054477
105Apoptosis_Homo sapiens_hsa042100.64939904
106Gap junction_Homo sapiens_hsa045400.64302770
107Glucagon signaling pathway_Homo sapiens_hsa049220.63716858
108N-Glycan biosynthesis_Homo sapiens_hsa005100.63030679
109Shigellosis_Homo sapiens_hsa051310.62892058
110Toll-like receptor signaling pathway_Homo sapiens_hsa046200.62052158
111Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61439408
112Toxoplasmosis_Homo sapiens_hsa051450.60732698
113Platelet activation_Homo sapiens_hsa046110.59591207
114Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58737990
115Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58229101
116Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.57966546
117Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.57442470
118FoxO signaling pathway_Homo sapiens_hsa040680.57270632
119Lysosome_Homo sapiens_hsa041420.56203996
120Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55982949
121Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55889378
122TNF signaling pathway_Homo sapiens_hsa046680.55848522
123Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.55413430
124Phospholipase D signaling pathway_Homo sapiens_hsa040720.55294294
125Dilated cardiomyopathy_Homo sapiens_hsa054140.55251945
126Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.54316693
127Long-term potentiation_Homo sapiens_hsa047200.54268371
128MAPK signaling pathway_Homo sapiens_hsa040100.53832890
129Selenocompound metabolism_Homo sapiens_hsa004500.53561515
130Endocytosis_Homo sapiens_hsa041440.51535027

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