NACC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)4.96429548
2neuronal action potential propagation (GO:0019227)4.86997919
3locomotory exploration behavior (GO:0035641)4.61271565
4regulation of short-term neuronal synaptic plasticity (GO:0048172)4.34616631
5cellular potassium ion homeostasis (GO:0030007)4.20966661
6glycine transport (GO:0015816)4.18172176
7sodium ion export (GO:0071436)4.10534008
8vocalization behavior (GO:0071625)4.05264949
9glutamate secretion (GO:0014047)4.05063449
10cytoskeletal anchoring at plasma membrane (GO:0007016)4.04244922
11synaptic vesicle exocytosis (GO:0016079)4.00352426
12positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.99235731
13regulation of synaptic vesicle exocytosis (GO:2000300)3.98644771
14positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.96410941
15gamma-aminobutyric acid transport (GO:0015812)3.93705484
16L-amino acid import (GO:0043092)3.71431290
17neurotransmitter secretion (GO:0007269)3.69453749
18regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.69124056
19neuromuscular process controlling posture (GO:0050884)3.67511358
20membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.66938398
21regulation of ARF protein signal transduction (GO:0032012)3.62914136
22cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.62898028
23protein localization to endosome (GO:0036010)3.62676367
24regulation of synaptic vesicle transport (GO:1902803)3.56288566
25synaptic vesicle docking involved in exocytosis (GO:0016081)3.54189684
26potassium ion import (GO:0010107)3.50436752
27ionotropic glutamate receptor signaling pathway (GO:0035235)3.47031239
28regulation of synapse structural plasticity (GO:0051823)3.44856164
29positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.44165217
30proline transport (GO:0015824)3.41983967
31exploration behavior (GO:0035640)3.35445702
32regulation of glutamate receptor signaling pathway (GO:1900449)3.34236974
33regulation of neuronal synaptic plasticity (GO:0048168)3.33560822
34regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.33099949
35cell communication by electrical coupling (GO:0010644)3.32715385
36neuron cell-cell adhesion (GO:0007158)3.28523494
37protein localization to synapse (GO:0035418)3.22106429
38negative regulation of synaptic transmission, GABAergic (GO:0032229)3.18151588
39axon ensheathment in central nervous system (GO:0032291)3.17150453
40central nervous system myelination (GO:0022010)3.17150453
41neurotransmitter transport (GO:0006836)3.16432391
42potassium ion homeostasis (GO:0055075)3.15995089
43layer formation in cerebral cortex (GO:0021819)3.14082016
44neuromuscular process controlling balance (GO:0050885)3.12975560
45membrane depolarization during action potential (GO:0086010)3.08483584
46neurotransmitter-gated ion channel clustering (GO:0072578)3.07678969
47amino acid import (GO:0043090)3.07322140
48regulation of long-term neuronal synaptic plasticity (GO:0048169)3.07187913
49cellular sodium ion homeostasis (GO:0006883)3.06945738
50cerebellar Purkinje cell differentiation (GO:0021702)3.05193088
51synaptic transmission, glutamatergic (GO:0035249)3.03798401
52neurofilament cytoskeleton organization (GO:0060052)3.03003269
53negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.02876816
54activation of protein kinase A activity (GO:0034199)3.02012074
55response to auditory stimulus (GO:0010996)3.01925566
56glutamate receptor signaling pathway (GO:0007215)3.00468773
57positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.99951104
58positive regulation of potassium ion transmembrane transport (GO:1901381)2.99776693
59stress fiber assembly (GO:0043149)2.98438909
60neuron-neuron synaptic transmission (GO:0007270)2.94418131
61regulation of neurotransmitter levels (GO:0001505)2.92471005
62adult walking behavior (GO:0007628)2.92349116
63barbed-end actin filament capping (GO:0051016)2.89605802
64positive regulation of synaptic transmission, GABAergic (GO:0032230)2.88561483
65long-term memory (GO:0007616)2.88119182
66positive regulation of receptor recycling (GO:0001921)2.86979075
67positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.86108432
68dendrite morphogenesis (GO:0048813)2.85746126
69positive regulation of potassium ion transport (GO:0043268)2.84594515
70transmission of nerve impulse (GO:0019226)2.84368845
71cortical actin cytoskeleton organization (GO:0030866)2.83627338
72adherens junction assembly (GO:0034333)2.81711860
73regulation of voltage-gated calcium channel activity (GO:1901385)2.79822078
74regulation of early endosome to late endosome transport (GO:2000641)2.77961109
75negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.73568550
76membrane hyperpolarization (GO:0060081)2.73234666
77alanine transport (GO:0032328)2.73116306
78cell-substrate adherens junction assembly (GO:0007045)2.72814439
79focal adhesion assembly (GO:0048041)2.72814439
80regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.72266595
81G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.71699713
82neuronal ion channel clustering (GO:0045161)2.71335639
83cell communication involved in cardiac conduction (GO:0086065)2.70459488
84membrane repolarization (GO:0086009)2.70234901
85regulation of synaptic transmission, glutamatergic (GO:0051966)2.69664558
86axon cargo transport (GO:0008088)2.68922009
87neuromuscular process (GO:0050905)2.68221240
88regulation of excitatory postsynaptic membrane potential (GO:0060079)2.68208072
89auditory behavior (GO:0031223)2.67895016
90cell migration in hindbrain (GO:0021535)2.67418165
91cerebellar granule cell differentiation (GO:0021707)2.66258029
92regulation of neurotransmitter secretion (GO:0046928)2.65732632
93acidic amino acid transport (GO:0015800)2.64156938
94regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.63560778
95regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.63399181
96positive regulation of membrane potential (GO:0045838)2.62418663
97regulation of synaptic plasticity (GO:0048167)2.62360506
98dendritic spine morphogenesis (GO:0060997)2.61956850
99detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.61579938
100detection of temperature stimulus involved in sensory perception (GO:0050961)2.61579938
101protein targeting to plasma membrane (GO:0072661)2.61206517
102presynaptic membrane organization (GO:0097090)2.60447570
103positive regulation of synapse maturation (GO:0090129)2.60173331
104detection of temperature stimulus (GO:0016048)2.60023834
105regulation of neurotransmitter transport (GO:0051588)2.59962960
106cell-substrate junction assembly (GO:0007044)2.59516228
107prepulse inhibition (GO:0060134)2.59420387
108innervation (GO:0060384)2.58556988
109regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.58223757
110negative regulation of erythrocyte differentiation (GO:0045647)2.57293657
111membrane depolarization (GO:0051899)2.57106843
112positive regulation of macrophage cytokine production (GO:0060907)2.57067795
113import into cell (GO:0098657)2.56246174
114negative regulation of dendrite morphogenesis (GO:0050774)2.56211593
115neuronal action potential (GO:0019228)2.55625928
116neurotransmitter uptake (GO:0001504)2.55187587
117L-glutamate transport (GO:0015813)2.55071483
118regulation of postsynaptic membrane potential (GO:0060078)2.54617259
119cortical cytoskeleton organization (GO:0030865)2.54473439
120astrocyte development (GO:0014002)2.54260299
121astrocyte differentiation (GO:0048708)2.52358140
122semaphorin-plexin signaling pathway (GO:0071526)2.52036526
123peptidyl-tyrosine autophosphorylation (GO:0038083)2.49099090
124regulation of macrophage cytokine production (GO:0010935)2.44993690
125positive regulation of protein dephosphorylation (GO:0035307)2.43610024
126regulation of ARF GTPase activity (GO:0032312)2.43221090
127cellular response to catecholamine stimulus (GO:0071870)2.37982796
128cellular response to monoamine stimulus (GO:0071868)2.37982796
129myelin maintenance (GO:0043217)2.36708333
130mannose metabolic process (GO:0006013)2.30884897
131positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.30455424
132cell volume homeostasis (GO:0006884)2.29532592
133positive regulation of extracellular matrix organization (GO:1903055)2.29480901
134insulin-like growth factor receptor signaling pathway (GO:0048009)2.29391169
135regulation of amyloid precursor protein catabolic process (GO:1902991)2.28476878
136positive regulation of fibroblast migration (GO:0010763)2.27769041
137peripheral nervous system axon ensheathment (GO:0032292)2.27062778
138myelination in peripheral nervous system (GO:0022011)2.27062778
139regulation of extracellular matrix disassembly (GO:0010715)2.26735984
140regulation of beta-amyloid formation (GO:1902003)2.23809246
141adenosine receptor signaling pathway (GO:0001973)2.22959649
142synaptic vesicle endocytosis (GO:0048488)2.22270956
143positive regulation of cellular amide metabolic process (GO:0034250)2.21400117
144mating behavior (GO:0007617)2.21329922
145cellular response to epinephrine stimulus (GO:0071872)2.21118932
146signal complex assembly (GO:0007172)2.20110560
147activation of Rac GTPase activity (GO:0032863)2.19186337
148actin filament bundle organization (GO:0061572)2.17450542
149actin filament bundle assembly (GO:0051017)2.17450542
150negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.15476297
151postsynaptic membrane organization (GO:0001941)2.13844250
152vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.10157525
153cell-cell junction maintenance (GO:0045217)2.09776688
154positive regulation of Rap GTPase activity (GO:0032854)2.08698881
155negative regulation of inclusion body assembly (GO:0090084)2.08391927
156cerebellar Purkinje cell layer development (GO:0021680)2.07973799
157chondroitin sulfate catabolic process (GO:0030207)2.06572003
158basement membrane organization (GO:0071711)2.05123668
159negative regulation of fatty acid transport (GO:2000192)2.04424413
160response to laminar fluid shear stress (GO:0034616)2.04016754
161positive regulation of axon extension (GO:0045773)2.04002952
162actin filament capping (GO:0051693)2.02831587
163positive regulation of dendritic spine development (GO:0060999)2.00943770

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.71696650
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.98349403
3GBX2_23144817_ChIP-Seq_PC3_Human2.90902899
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.89070149
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.80855308
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.71553832
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.71553832
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.64353866
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.53985262
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.52192237
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.48663133
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.47569839
13KDM2B_26808549_Chip-Seq_SUP-B15_Human2.46686338
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.43717658
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.41551683
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.41071957
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.39701359
18DROSHA_22980978_ChIP-Seq_HELA_Human2.34213071
19TRIM28_21343339_ChIP-Seq_HEK293_Human2.33934892
20LXR_22292898_ChIP-Seq_THP-1_Human2.23023672
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.19962472
22EZH2_27304074_Chip-Seq_ESCs_Mouse2.19225269
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.14362036
24REST_21632747_ChIP-Seq_MESCs_Mouse2.08648244
25* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.06251466
26RNF2_27304074_Chip-Seq_ESCs_Mouse2.03725286
27RARB_27405468_Chip-Seq_BRAIN_Mouse1.88373001
28MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.88125261
29ZFP281_18757296_ChIP-ChIP_E14_Mouse1.85287768
30ELK3_25401928_ChIP-Seq_HUVEC_Human1.83902029
31AR_21572438_ChIP-Seq_LNCaP_Human1.83636645
32KDM2B_26808549_Chip-Seq_DND41_Human1.81432445
33KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.73952914
34RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.71917541
35STAT6_21828071_ChIP-Seq_BEAS2B_Human1.71634688
36REST_18959480_ChIP-ChIP_MESCs_Mouse1.71056325
37CLOCK_20551151_ChIP-Seq_293T_Human1.69226035
38RACK7_27058665_Chip-Seq_MCF-7_Human1.68115762
39NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.65152380
40TCF7_22412390_ChIP-Seq_EML_Mouse1.63911758
41IKZF1_21737484_ChIP-ChIP_HCT116_Human1.63867852
42ZFP281_27345836_Chip-Seq_ESCs_Mouse1.59565833
43EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.58169142
44ERG_21242973_ChIP-ChIP_JURKAT_Human1.56519127
45CDX2_19796622_ChIP-Seq_MESCs_Mouse1.56435402
46* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.54530237
47EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.50996582
48P300_27058665_Chip-Seq_ZR-75-30cells_Human1.50412562
49KDM2B_26808549_Chip-Seq_JURKAT_Human1.50058596
50UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.45544753
51GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.44148378
52SMAD4_21799915_ChIP-Seq_A2780_Human1.42170182
53PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.42083419
54VDR_21846776_ChIP-Seq_THP-1_Human1.38306444
55PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36890486
56PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35608087
57CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.34751640
58* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.32231184
59ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.31884506
60* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.31558993
61TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.28167300
62TAF15_26573619_Chip-Seq_HEK293_Human1.27658273
63CTBP2_25329375_ChIP-Seq_LNCAP_Human1.27205662
64* TBX20_22328084_ChIP-Seq_HEART_Mouse1.26769675
65* TBX20_22080862_ChIP-Seq_HEART_Mouse1.26769675
66RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25599854
67SMAD_19615063_ChIP-ChIP_OVARY_Human1.25445126
68GATA2_21666600_ChIP-Seq_HMVEC_Human1.23892658
69SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23834851
70RING1B_27294783_Chip-Seq_ESCs_Mouse1.22342062
71* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.22298502
72NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21682951
73ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.21391781
74SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.20767006
75SOX9_24532713_ChIP-Seq_HFSC_Mouse1.20696809
76* SMC4_20622854_ChIP-Seq_HELA_Human1.20680837
77NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.19937126
78ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.19687487
79ESR1_21235772_ChIP-Seq_MCF-7_Human1.19526512
80* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19370394
81SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19100169
82ESR2_21235772_ChIP-Seq_MCF-7_Human1.18193715
83KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.17181080
84PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.17180807
85PIAS1_25552417_ChIP-Seq_VCAP_Human1.16993243
86* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.14815485
87ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14189116
88KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.12787094
89ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.11983559
90KDM2B_26808549_Chip-Seq_K562_Human1.11809041
91SOX2_21211035_ChIP-Seq_LN229_Gbm1.11466387
92GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10934519
93GATA1_19941827_ChIP-Seq_MEL_Mouse1.10596486
94TP53_23651856_ChIP-Seq_MEFs_Mouse1.10492184
95OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09812803
96CTBP1_25329375_ChIP-Seq_LNCAP_Human1.09558487
97AR_25329375_ChIP-Seq_VCAP_Human1.09431205
98AHR_22903824_ChIP-Seq_MCF-7_Human1.09359009
99SMC1_22415368_ChIP-Seq_MEFs_Mouse1.08354321
100NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.08286756
101DNAJC2_21179169_ChIP-ChIP_NT2_Human1.08078301
102KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.07597107
103* STAT3_23295773_ChIP-Seq_U87_Human1.07386449
104* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.07225852
105CTCF_27219007_Chip-Seq_ERYTHROID_Human1.06221776
106ARNT_22903824_ChIP-Seq_MCF-7_Human1.05558078
107P300_19829295_ChIP-Seq_ESCs_Human1.05361501
108EP300_21415370_ChIP-Seq_HL-1_Mouse1.05057384
109CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.04981310
110AR_19668381_ChIP-Seq_PC3_Human1.04625736
111CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.04308411
112SMAD3_21741376_ChIP-Seq_EPCs_Human1.03229980
113NFIB_24661679_ChIP-Seq_LUNG_Mouse1.03092620
114ESR1_20079471_ChIP-ChIP_T-47D_Human1.02844458
115* CREB1_26743006_Chip-Seq_LNCaP_Human1.02119765
116TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01266997
117* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.00780674
118ZFP57_27257070_Chip-Seq_ESCs_Mouse0.98179714
119MYB_21317192_ChIP-Seq_ERMYB_Mouse0.98061611
120SMAD4_21741376_ChIP-Seq_HESCs_Human0.97765530
121RING1B_27294783_Chip-Seq_NPCs_Mouse0.97618449
122OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.97585935
123TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97509171
124AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97442430
125THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.97429672
126EGR1_19374776_ChIP-ChIP_THP-1_Human0.96616428
127WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.96298453
128RXR_22108803_ChIP-Seq_LS180_Human0.95567503
129BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95108669
130ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.94991958
131VDR_24763502_ChIP-Seq_THP-1_Human0.94621802
132* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94147180
133GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93874097
134SPI1_23127762_ChIP-Seq_K562_Human0.93872432
135SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.93704505
136CBX2_27304074_Chip-Seq_ESCs_Mouse0.93181669
137SA1_27219007_Chip-Seq_ERYTHROID_Human0.93171676
138SMAD3_21741376_ChIP-Seq_HESCs_Human0.92327241
139ZNF274_21170338_ChIP-Seq_K562_Hela0.92122762
140TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91743164
141TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91501351
142SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91321495
143MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90858620
144VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.90476542
145NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90027812
146EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.89588440
147P53_22127205_ChIP-Seq_FIBROBLAST_Human0.88699551
148NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.88278377
149NRF2_20460467_ChIP-Seq_MEFs_Mouse0.88278377
150TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.87943162
151TET1_21490601_ChIP-Seq_MESCs_Mouse0.86726977
152TCF4_23295773_ChIP-Seq_U87_Human0.86703299
153CTNNB1_20460455_ChIP-Seq_HCT116_Human0.85835627
154PRDM14_20953172_ChIP-Seq_ESCs_Human0.83496019
155YAP1_20516196_ChIP-Seq_MESCs_Mouse0.83341880
156RUNX2_22187159_ChIP-Seq_PCA_Human0.82698449
157BCAT_22108803_ChIP-Seq_LS180_Human0.82110520
158SMAD4_21741376_ChIP-Seq_EPCs_Human0.82027432
159BMI1_23680149_ChIP-Seq_NPCS_Mouse0.81966830
160CTCF_27219007_Chip-Seq_Bcells_Human0.81586871

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.03957587
2MP0003705_abnormal_hypodermis_morpholog4.38632660
3MP0003880_abnormal_central_pattern3.67677850
4MP0004270_analgesia3.58708837
5MP0003635_abnormal_synaptic_transmissio3.40322175
6MP0001968_abnormal_touch/_nociception3.19346444
7MP0009046_muscle_twitch3.15856425
8MP0002735_abnormal_chemical_nociception2.95608962
9MP0008438_abnormal_cutaneous_collagen2.95258188
10MP0002064_seizures2.87400016
11MP0001958_emphysema2.83967051
12MP0009745_abnormal_behavioral_response2.81266269
13MP0002272_abnormal_nervous_system2.72479110
14MP0002734_abnormal_mechanical_nocicepti2.69927490
15MP0004858_abnormal_nervous_system2.69039315
16MP0002736_abnormal_nociception_after2.67610859
17MP0001486_abnormal_startle_reflex2.54274817
18MP0005423_abnormal_somatic_nervous2.49245493
19MP0002063_abnormal_learning/memory/cond2.47528522
20MP0005409_darkened_coat_color2.36710951
21MP0002733_abnormal_thermal_nociception2.29931879
22MP0003329_amyloid_beta_deposits2.29823564
23MP0003566_abnormal_cell_adhesion2.29759873
24MP0008569_lethality_at_weaning2.21982586
25MP0002572_abnormal_emotion/affect_behav2.18347576
26MP0001970_abnormal_pain_threshold2.16727519
27MP0002067_abnormal_sensory_capabilities2.11583639
28MP0003191_abnormal_cellular_cholesterol2.09495463
29MP0003279_aneurysm1.98691235
30MP0004885_abnormal_endolymph1.96838421
31MP0002822_catalepsy1.96743645
32MP0003091_abnormal_cell_migration1.96299181
33MP0008260_abnormal_autophagy1.94899867
34MP0003690_abnormal_glial_cell1.92962683
35MP0002877_abnormal_melanocyte_morpholog1.89371591
36MP0001501_abnormal_sleep_pattern1.88987866
37MP0000920_abnormal_myelination1.83072952
38MP0005058_abnormal_lysosome_morphology1.76182780
39MP0001440_abnormal_grooming_behavior1.75200271
40MP0006276_abnormal_autonomic_nervous1.72973785
41MP0009780_abnormal_chondrocyte_physiolo1.72355454
42MP0004142_abnormal_muscle_tone1.71121952
43MP0002909_abnormal_adrenal_gland1.66375800
44MP0002184_abnormal_innervation1.64883109
45MP0003633_abnormal_nervous_system1.62150504
46MP0000955_abnormal_spinal_cord1.61932598
47MP0003879_abnormal_hair_cell1.60716820
48MP0001849_ear_inflammation1.59177552
49MP0000751_myopathy1.51610527
50MP0005646_abnormal_pituitary_gland1.50831989
51MP0004811_abnormal_neuron_physiology1.48083444
52MP0000778_abnormal_nervous_system1.46436246
53MP0003634_abnormal_glial_cell1.46255869
54MP0003300_gastrointestinal_ulcer1.42438652
55MP0005076_abnormal_cell_differentiation1.40569671
56MP0004272_abnormal_basement_membrane1.40342630
57MP0002557_abnormal_social/conspecific_i1.39951372
58MP0005386_behavior/neurological_phenoty1.39639308
59MP0004924_abnormal_behavior1.39639308
60MP0003303_peritoneal_inflammation1.37262110
61MP0002066_abnormal_motor_capabilities/c1.36238694
62MP0003631_nervous_system_phenotype1.32347641
63MP0002882_abnormal_neuron_morphology1.29472406
64MP0004510_myositis1.29349209
65MP0004145_abnormal_muscle_electrophysio1.29034376
66MP0002229_neurodegeneration1.21927266
67MP0004742_abnormal_vestibular_system1.20473642
68MP0000604_amyloidosis1.20145530
69MP0001984_abnormal_olfaction1.20108441
70MP0005023_abnormal_wound_healing1.19462729
71MP0001485_abnormal_pinna_reflex1.18955107
72MP0003828_pulmonary_edema1.14512661
73MP0010368_abnormal_lymphatic_system1.13693465
74MP0005451_abnormal_body_composition1.13176114
75MP0003453_abnormal_keratinocyte_physiol1.12950874
76MP0004233_abnormal_muscle_weight1.11939511
77MP0000767_abnormal_smooth_muscle1.11556610
78MP0002896_abnormal_bone_mineralization1.09101026
79MP0005623_abnormal_meninges_morphology1.08945571
80MP0005595_abnormal_vascular_smooth1.08809722
81MP0009840_abnormal_foam_cell1.08423705
82MP0000013_abnormal_adipose_tissue1.07999403
83MP0005257_abnormal_intraocular_pressure1.07577753
84MP0005388_respiratory_system_phenotype1.07139499
85MP0002133_abnormal_respiratory_system1.07139499
86MP0005645_abnormal_hypothalamus_physiol1.05786973
87MP0003632_abnormal_nervous_system1.04342567
88MP0001915_intracranial_hemorrhage1.03738834
89MP0004130_abnormal_muscle_cell1.03160155
90MP0001299_abnormal_eye_distance/1.02032400
91MP0001963_abnormal_hearing_physiology0.99374114
92MP0004147_increased_porphyrin_level0.98291523
93MP0001502_abnormal_circadian_rhythm0.97732732
94MP0002249_abnormal_larynx_morphology0.96488508
95MP0001177_atelectasis0.95545752
96MP0002998_abnormal_bone_remodeling0.95239732
97MP0005166_decreased_susceptibility_to0.95145353
98MP0000733_abnormal_muscle_development0.94629404
99MP0004043_abnormal_pH_regulation0.92858132
100MP0009278_abnormal_bone_marrow0.92005882
101MP0003075_altered_response_to0.90035015
102MP0004087_abnormal_muscle_fiber0.89899961
103MP0005171_absent_coat_pigmentation0.89506615
104MP0006138_congestive_heart_failure0.89344154
105MP0001905_abnormal_dopamine_level0.88445891
106MP0008874_decreased_physiological_sensi0.87951086
107MP0000747_muscle_weakness0.86732436
108MP0005535_abnormal_body_temperature0.86570723
109MP0001986_abnormal_taste_sensitivity0.86474595
110MP0003646_muscle_fatigue0.86247272
111MP0002089_abnormal_postnatal_growth/wei0.85826013
112MP0005666_abnormal_adipose_tissue0.85616034
113MP0004185_abnormal_adipocyte_glucose0.84700552
114MP0005167_abnormal_blood-brain_barrier0.84335786
115MP0005165_increased_susceptibility_to0.83860659
116MP0003436_decreased_susceptibility_to0.82346614
117MP0000759_abnormal_skeletal_muscle0.81992817
118MP0002152_abnormal_brain_morphology0.81175543
119MP0005670_abnormal_white_adipose0.80784319
120MP0003137_abnormal_impulse_conducting0.77694591
121MP0005275_abnormal_skin_tensile0.77311508
122MP0005375_adipose_tissue_phenotype0.77031110
123MP0003045_fibrosis0.76674512
124MP0002295_abnormal_pulmonary_circulatio0.76576690
125MP0002752_abnormal_somatic_nervous0.76207581
126MP0010234_abnormal_vibrissa_follicle0.75964286
127MP0001533_abnormal_skeleton_physiology0.75688211
128MP0004215_abnormal_myocardial_fiber0.74754902
129MP0000749_muscle_degeneration0.73444497
130MP0002069_abnormal_eating/drinking_beha0.73442230
131MP0002060_abnormal_skin_morphology0.72976815
132MP0002837_dystrophic_cardiac_calcinosis0.72950428
133MP0002090_abnormal_vision0.72009011
134MP0004085_abnormal_heartbeat0.71532897
135MP0010630_abnormal_cardiac_muscle0.71390401
136MP0002971_abnormal_brown_adipose0.70270540
137MP0000534_abnormal_ureter_morphology0.70110979
138MP0004484_altered_response_of0.69928534
139MP0003172_abnormal_lysosome_physiology0.69712306
140MP0005551_abnormal_eye_electrophysiolog0.69323666
141MP0005621_abnormal_cell_physiology0.69255775
142MP0000858_altered_metastatic_potential0.68188644
143MP0008872_abnormal_physiological_respon0.67069520
144MP0003283_abnormal_digestive_organ0.66251505
145MP0005377_hearing/vestibular/ear_phenot0.65509059
146MP0003878_abnormal_ear_physiology0.65509059
147MP0001348_abnormal_lacrimal_gland0.65290574
148MP0001529_abnormal_vocalization0.64919974
149MP0004036_abnormal_muscle_relaxation0.59193727
150MP0001188_hyperpigmentation0.57136838
151MP0001664_abnormal_digestion0.56660189
152MP0003183_abnormal_peptide_metabolism0.55107976
153MP0002876_abnormal_thyroid_physiology0.52249505
154MP0000026_abnormal_inner_ear0.52225646
155MP0005620_abnormal_muscle_contractility0.50496333
156MP0010386_abnormal_urinary_bladder0.50355401

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.52454162
2Focal motor seizures (HP:0011153)6.03591258
3Action tremor (HP:0002345)5.51119919
4Focal seizures (HP:0007359)4.49422746
5Supranuclear gaze palsy (HP:0000605)4.40487481
6Progressive cerebellar ataxia (HP:0002073)4.01213848
7Obstructive sleep apnea (HP:0002870)3.78423888
8Visual hallucinations (HP:0002367)3.76385982
9Ankle clonus (HP:0011448)3.76270538
10Atonic seizures (HP:0010819)3.73003890
11Febrile seizures (HP:0002373)3.65791635
12Ulnar claw (HP:0001178)3.62031940
13Protrusio acetabuli (HP:0003179)3.56657888
14Pheochromocytoma (HP:0002666)3.31232996
15Premature rupture of membranes (HP:0001788)3.20595428
16Cerebral aneurysm (HP:0004944)3.16100826
17Abnormal eating behavior (HP:0100738)3.14130348
18Neurofibrillary tangles (HP:0002185)3.13214206
19Epileptic encephalopathy (HP:0200134)3.12836703
20Generalized tonic-clonic seizures (HP:0002069)3.10492544
21Scanning speech (HP:0002168)3.00521051
22Dysmetria (HP:0001310)2.99689969
23Arterial tortuosity (HP:0005116)2.98259752
24Termporal pattern (HP:0011008)2.98147399
25Insidious onset (HP:0003587)2.98147399
26Intention tremor (HP:0002080)2.97235438
27Dysdiadochokinesis (HP:0002075)2.97019678
28Vascular tortuosity (HP:0004948)2.92571196
29Absence seizures (HP:0002121)2.92210168
30Onion bulb formation (HP:0003383)2.90826387
31Hemiplegia (HP:0002301)2.88475330
32Depression (HP:0000716)2.83694591
33Gaze-evoked nystagmus (HP:0000640)2.83445072
34Neuroendocrine neoplasm (HP:0100634)2.82988119
35Truncal ataxia (HP:0002078)2.81533072
36Peripheral hypomyelination (HP:0007182)2.81449415
37Postural instability (HP:0002172)2.80915972
38Shallow orbits (HP:0000586)2.80834674
39Ventricular fibrillation (HP:0001663)2.80553780
40Hyperacusis (HP:0010780)2.76059765
41Dialeptic seizures (HP:0011146)2.75796845
42Anxiety (HP:0000739)2.73600123
43Megalencephaly (HP:0001355)2.72746946
44Torticollis (HP:0000473)2.64166212
45Bundle branch block (HP:0011710)2.64150988
46Segmental peripheral demyelination/remyelination (HP:0003481)2.58348663
47Urinary urgency (HP:0000012)2.57696453
48Mitral regurgitation (HP:0001653)2.55245011
49Hammertoe (HP:0001765)2.54234895
50Urinary bladder sphincter dysfunction (HP:0002839)2.54219392
51Spastic gait (HP:0002064)2.53648110
52Hyporeflexia of lower limbs (HP:0002600)2.52011351
53Increased variability in muscle fiber diameter (HP:0003557)2.49651022
54Aplasia involving bones of the upper limbs (HP:0009823)2.45914286
55Aplasia of the phalanges of the hand (HP:0009802)2.45914286
56Aplasia involving bones of the extremities (HP:0009825)2.45914286
57Ulnar bowing (HP:0003031)2.44674672
58Progressive inability to walk (HP:0002505)2.43016146
59Mutism (HP:0002300)2.42470571
60Abnormal social behavior (HP:0012433)2.39341276
61Impaired social interactions (HP:0000735)2.39341276
62Aortic aneurysm (HP:0004942)2.38187511
63Poor eye contact (HP:0000817)2.37780483
64Cerebral inclusion bodies (HP:0100314)2.34321570
65Increased connective tissue (HP:0009025)2.34129637
66Broad face (HP:0000283)2.33127373
67Distal lower limb muscle weakness (HP:0009053)2.33108271
68Postural tremor (HP:0002174)2.31930625
69Hemiparesis (HP:0001269)2.31402173
70Lower limb amyotrophy (HP:0007210)2.30857759
71Focal dystonia (HP:0004373)2.29813465
72Impaired vibration sensation in the lower limbs (HP:0002166)2.29050888
73Lower limb muscle weakness (HP:0007340)2.27229817
74Slow saccadic eye movements (HP:0000514)2.25101744
75Aortic dissection (HP:0002647)2.22112778
76Foot dorsiflexor weakness (HP:0009027)2.22085883
77Upper limb amyotrophy (HP:0009129)2.21980981
78Distal upper limb amyotrophy (HP:0007149)2.21980981
79Abnormality of saccadic eye movements (HP:0000570)2.19975444
80Craniofacial dystonia (HP:0012179)2.19124960
81Atrophic scars (HP:0001075)2.17687838
82Vertebral compression fractures (HP:0002953)2.17627241
83Broad-based gait (HP:0002136)2.17285575
84Fragile skin (HP:0001030)2.17202743
85Wormian bones (HP:0002645)2.16153669
86Abnormality of skeletal muscle fiber size (HP:0012084)2.15826109
87Mitral stenosis (HP:0001718)2.15541373
88Bradycardia (HP:0001662)2.15316937
89Dilatation of the ascending aorta (HP:0005111)2.14726138
90Steppage gait (HP:0003376)2.14411246
91Abnormality of the corticospinal tract (HP:0002492)2.12277365
92Distal lower limb amyotrophy (HP:0008944)2.11297809
93Neoplasm of the peripheral nervous system (HP:0100007)2.07187805
94Abnormality of binocular vision (HP:0011514)2.06445038
95Diplopia (HP:0000651)2.06445038
96Myotonia (HP:0002486)2.04681052
97Fetal akinesia sequence (HP:0001989)2.04337427
98Spinal rigidity (HP:0003306)2.03642614
99Amyloidosis (HP:0011034)2.03458531
100Turricephaly (HP:0000262)2.03216884
101Bladder diverticulum (HP:0000015)2.02630052
102Bradykinesia (HP:0002067)2.01371067
103Genetic anticipation (HP:0003743)2.00869055
104Status epilepticus (HP:0002133)2.00604733
105Neuronal loss in central nervous system (HP:0002529)2.00586921
106Aneurysm (HP:0002617)1.99183202
107Retinal dysplasia (HP:0007973)1.98926703
108Clonus (HP:0002169)1.98480880
109Dysmetric saccades (HP:0000641)1.98402378
110Difficulty climbing stairs (HP:0003551)1.96885296
111Mitral valve prolapse (HP:0001634)1.96594490
112Papilledema (HP:0001085)1.96129168
113Abnormality of the foot musculature (HP:0001436)1.95975537
114Decreased motor nerve conduction velocity (HP:0003431)1.94869777
115Rapidly progressive (HP:0003678)1.92720173
116Agitation (HP:0000713)1.92257886
117Prolonged QT interval (HP:0001657)1.91731938
118Rigidity (HP:0002063)1.91383506
119Hypercortisolism (HP:0001578)1.89775225
120Distal sensory impairment (HP:0002936)1.89181275
121Osteolytic defects of the phalanges of the hand (HP:0009771)1.88964094
122Osteolytic defects of the hand bones (HP:0009699)1.88964094
123Difficulty running (HP:0009046)1.88270862
124Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.87944990
125Gait ataxia (HP:0002066)1.87675793
126Peritonitis (HP:0002586)1.87104588
127Annular pancreas (HP:0001734)1.86834710
128Increased circulating renin level (HP:0000848)1.84759828
129Nuclear cataract (HP:0100018)1.84644893
130Heart block (HP:0012722)1.84031436
131Centrally nucleated skeletal muscle fibers (HP:0003687)1.83096282
132Insomnia (HP:0100785)1.82833924
133Broad metatarsal (HP:0001783)1.82465631
134Muscle fiber splitting (HP:0003555)1.81637188
135Hyperextensible skin (HP:0000974)1.81098379
136Limb dystonia (HP:0002451)1.79886726
137Axonal loss (HP:0003447)1.78643492
138Genu recurvatum (HP:0002816)1.77758259
139Slow progression (HP:0003677)1.77337242
140Impaired vibratory sensation (HP:0002495)1.76433808
141Abnormality of pain sensation (HP:0010832)1.76337226
142Impaired pain sensation (HP:0007328)1.76337226
143Tetraplegia (HP:0002445)1.76304486
144Bronchomalacia (HP:0002780)1.75797282
145Achilles tendon contracture (HP:0001771)1.75464350
146Arnold-Chiari malformation (HP:0002308)1.75289232
147Hyperparathyroidism (HP:0000843)1.74991823
148Lower limb asymmetry (HP:0100559)1.74606173
149Blue sclerae (HP:0000592)1.74392562
150Abnormal EKG (HP:0003115)1.74209807
151Abnormality of the lower motor neuron (HP:0002366)1.72458563
152Ankle contracture (HP:0006466)1.71827367
153Apathy (HP:0000741)1.71636579
154Stridor (HP:0010307)1.71124557
155Overgrowth (HP:0001548)1.70497985
156Hand muscle atrophy (HP:0009130)1.70256665
157Neonatal short-limb short stature (HP:0008921)1.66086154
158Vertebral arch anomaly (HP:0008438)1.65571783
159Bowel diverticulosis (HP:0005222)1.64668233
160Disproportionate tall stature (HP:0001519)1.62718713
161Pointed chin (HP:0000307)1.61069827
162Ankyloglossia (HP:0010296)1.61051370
163Elfin facies (HP:0004428)1.59265431
164Type 1 muscle fiber predominance (HP:0003803)1.58535004
165Short nail (HP:0001799)1.58059881

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.64395150
2MAP3K92.89146363
3LMTK22.85283068
4MINK12.66985521
5NTRK12.40787286
6EPHA42.32894409
7MAP3K42.25565363
8TTN2.25208904
9PAK62.23376306
10MAP2K72.08070776
11PHKG22.05036517
12PHKG12.05036517
13PRKD32.01040442
14MARK11.93633325
15CAMKK11.92996595
16KSR21.87872475
17ERN11.85607030
18ICK1.85605370
19WNK11.84601261
20MAP2K41.84414211
21NTRK21.75584450
22MAP3K121.71949061
23PINK11.70583175
24STK381.69853698
25CAMKK21.64273648
26CASK1.62590653
27TNIK1.56924012
28DAPK21.52748550
29SGK4941.50882423
30SGK2231.50882423
31STK391.47858944
32MUSK1.39432382
33CDK51.35381737
34SMG11.35171581
35GRK51.34879852
36LATS21.31789299
37MAP2K31.26072324
38PTK21.24597991
39MAPK131.23178340
40MAP3K21.20707486
41RET1.18910817
42EEF2K1.18514906
43OXSR11.16534081
44TESK11.14527999
45UHMK11.14514102
46IRAK31.13569858
47ARAF1.13385389
48PRKD21.12062701
49MAPKAPK51.09137139
50PRKCH1.09136572
51DDR21.06585928
52MOS1.05593752
53SGK21.01556299
54FES1.01510623
55RIPK41.00827063
56RIPK11.00006774
57FGFR40.97894750
58CDK190.97716442
59PRKCG0.97311138
60LIMK10.96913613
61SGK30.96542543
62MAP3K30.96465402
63MAPK120.96373899
64CAMK2G0.94460182
65WNK40.94086889
66CAMK10.90847649
67PAK30.90821736
68TNK20.89325515
69PAK20.87558868
70CDK120.87205564
71FER0.85185127
72PDGFRB0.84729463
73PKN20.83588620
74TYRO30.83367798
75CAMK2A0.82588666
76PRPF4B0.81395064
77ROCK20.79791756
78TAOK20.79233172
79PDPK10.77717724
80STK110.77137989
81CAMK2D0.76848714
82PTK60.75969297
83CAMK2B0.75879560
84CAMK1G0.75626307
85MTOR0.75068240
86MAP3K10.74298499
87MAP3K110.72907340
88NEK60.71435469
89JAK10.71123443
90PAK40.70405599
91CDK140.70012217
92MARK20.69057306
93PRKCE0.66638895
94PDK10.65808873
95BMX0.65689613
96NEK90.65638785
97CDK150.64786518
98MET0.64424298
99EPHB10.64415056
100PLK20.63587106
101PTK2B0.63016238
102CDK180.62654647
103CSNK1G20.61955326
104ROCK10.60724695
105PDGFRA0.58828589
106TRIB30.58496415
107MYLK0.58299199
108SIK20.56581561
109MAP3K70.56372078
110PRKG20.55415482
111SGK10.55319803
112CDK11A0.54670996
113CDC42BPA0.54542795
114PRKD10.53965674
115TAOK10.53845812
116EPHA20.53555821
117TGFBR20.52194740
118MAP2K10.52147208
119RAF10.51223633
120CSK0.51152647
121SIK10.50577857
122ZAP700.49836179
123KSR10.49717185
124MAP3K130.49499011
125CAMK1D0.48757746
126ALK0.48494497
127FGFR30.47325871
128IRAK20.47249628
129FGFR20.46964534
130PRKCZ0.46625734
131RPS6KA30.46422440
132FYN0.46240012
133PKN10.45902395
134DMPK0.44588182
135RPS6KA20.43565623
136CAMK40.43276984
137MAPK100.41642701

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.24934193
2Synaptic vesicle cycle_Homo sapiens_hsa047212.77272123
3Nicotine addiction_Homo sapiens_hsa050332.59548282
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.26679990
5GABAergic synapse_Homo sapiens_hsa047272.25514253
6Olfactory transduction_Homo sapiens_hsa047402.17046869
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.15920204
8Glutamatergic synapse_Homo sapiens_hsa047242.08948838
9Circadian entrainment_Homo sapiens_hsa047132.03149594
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.98064238
11Salivary secretion_Homo sapiens_hsa049701.87298804
12Gastric acid secretion_Homo sapiens_hsa049711.86172095
13Morphine addiction_Homo sapiens_hsa050321.85660705
14Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.83273190
15Long-term potentiation_Homo sapiens_hsa047201.74591228
16Insulin secretion_Homo sapiens_hsa049111.65837157
17Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.58368678
18Dopaminergic synapse_Homo sapiens_hsa047281.57383972
19Amphetamine addiction_Homo sapiens_hsa050311.54562458
20Taste transduction_Homo sapiens_hsa047421.52391001
21Cholinergic synapse_Homo sapiens_hsa047251.51739711
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.49646496
23Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.45250587
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.42522023
25Long-term depression_Homo sapiens_hsa047301.37295900
26Renin secretion_Homo sapiens_hsa049241.31021480
27Focal adhesion_Homo sapiens_hsa045101.29923465
28Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.26489400
29Chronic myeloid leukemia_Homo sapiens_hsa052201.26344187
30Calcium signaling pathway_Homo sapiens_hsa040201.22928121
31Cocaine addiction_Homo sapiens_hsa050301.18777384
32Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.18294209
33Oxytocin signaling pathway_Homo sapiens_hsa049211.16944185
34Serotonergic synapse_Homo sapiens_hsa047261.15428094
35Endometrial cancer_Homo sapiens_hsa052131.14375617
36GnRH signaling pathway_Homo sapiens_hsa049121.13427609
37AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.13255207
38Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.11683622
39Non-small cell lung cancer_Homo sapiens_hsa052231.11360364
40Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.09852383
41Gap junction_Homo sapiens_hsa045401.09697047
42cAMP signaling pathway_Homo sapiens_hsa040241.09548328
43Amoebiasis_Homo sapiens_hsa051461.08961633
44Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.07266202
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.04991139
46Dorso-ventral axis formation_Homo sapiens_hsa043201.03193000
47Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02808130
48ECM-receptor interaction_Homo sapiens_hsa045121.02452562
49Bile secretion_Homo sapiens_hsa049761.00457581
50Proteoglycans in cancer_Homo sapiens_hsa052050.99473081
51Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.99385667
52mTOR signaling pathway_Homo sapiens_hsa041500.99164158
53Notch signaling pathway_Homo sapiens_hsa043300.98293253
54Other glycan degradation_Homo sapiens_hsa005110.96364865
55Leukocyte transendothelial migration_Homo sapiens_hsa046700.96214058
56Fatty acid biosynthesis_Homo sapiens_hsa000610.94958879
57Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.94213880
58Central carbon metabolism in cancer_Homo sapiens_hsa052300.92555261
59Collecting duct acid secretion_Homo sapiens_hsa049660.92239569
60Cardiac muscle contraction_Homo sapiens_hsa042600.92091468
61Glioma_Homo sapiens_hsa052140.91408610
62Regulation of actin cytoskeleton_Homo sapiens_hsa048100.90590503
63Pancreatic cancer_Homo sapiens_hsa052120.90408257
64Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.90220532
65Glycosaminoglycan degradation_Homo sapiens_hsa005310.90084033
66Type II diabetes mellitus_Homo sapiens_hsa049300.89889574
67Osteoclast differentiation_Homo sapiens_hsa043800.89598179
68Acute myeloid leukemia_Homo sapiens_hsa052210.88097736
69Adherens junction_Homo sapiens_hsa045200.87562064
70Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.86854438
71Estrogen signaling pathway_Homo sapiens_hsa049150.85222341
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.84748848
73Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.83080714
74ErbB signaling pathway_Homo sapiens_hsa040120.81987701
75Axon guidance_Homo sapiens_hsa043600.81554434
76Butanoate metabolism_Homo sapiens_hsa006500.80683079
77Arginine biosynthesis_Homo sapiens_hsa002200.80468947
78Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.80068548
79Pancreatic secretion_Homo sapiens_hsa049720.79851590
80Thyroid hormone synthesis_Homo sapiens_hsa049180.79449720
81Melanogenesis_Homo sapiens_hsa049160.79291025
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.79146365
83cGMP-PKG signaling pathway_Homo sapiens_hsa040220.78523974
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.77657435
85Dilated cardiomyopathy_Homo sapiens_hsa054140.75304096
86Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75271122
87Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.74929002
88AMPK signaling pathway_Homo sapiens_hsa041520.73157044
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.73142829
90Platelet activation_Homo sapiens_hsa046110.71898066
91Prolactin signaling pathway_Homo sapiens_hsa049170.69145708
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68192157
93Bladder cancer_Homo sapiens_hsa052190.66315302
94Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.64848213
95B cell receptor signaling pathway_Homo sapiens_hsa046620.64711196
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63749345
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63340202
98HIF-1 signaling pathway_Homo sapiens_hsa040660.63216915
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.62141676
100Salmonella infection_Homo sapiens_hsa051320.60420945
101Fatty acid metabolism_Homo sapiens_hsa012120.59190970
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.59160994
103Choline metabolism in cancer_Homo sapiens_hsa052310.57927384
104Endocytosis_Homo sapiens_hsa041440.55765712
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.55419903
106Mineral absorption_Homo sapiens_hsa049780.52803106
107Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51823538
108Vibrio cholerae infection_Homo sapiens_hsa051100.51683076
109Fatty acid elongation_Homo sapiens_hsa000620.50999894
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.50737758
111Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50564915
112Ras signaling pathway_Homo sapiens_hsa040140.50409219
113Insulin signaling pathway_Homo sapiens_hsa049100.49998094
114Rap1 signaling pathway_Homo sapiens_hsa040150.49413508
115Inositol phosphate metabolism_Homo sapiens_hsa005620.49171684
116Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47847698
117MAPK signaling pathway_Homo sapiens_hsa040100.47191911
118PPAR signaling pathway_Homo sapiens_hsa033200.46137812
119Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.45774556
120Prion diseases_Homo sapiens_hsa050200.45407502
121Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44776325
122Ovarian steroidogenesis_Homo sapiens_hsa049130.44596966
123Propanoate metabolism_Homo sapiens_hsa006400.43817819
124Glucagon signaling pathway_Homo sapiens_hsa049220.42330679
125Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41094231
126Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.39819014
127Glycerolipid metabolism_Homo sapiens_hsa005610.39801207
128Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.39702479
1292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.38300213
130Renal cell carcinoma_Homo sapiens_hsa052110.33980128
131Melanoma_Homo sapiens_hsa052180.33493251
132Adipocytokine signaling pathway_Homo sapiens_hsa049200.32912403
133Vitamin B6 metabolism_Homo sapiens_hsa007500.32783393
134VEGF signaling pathway_Homo sapiens_hsa043700.31851053

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