NADK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: NADK catalyzes the transfer of a phosphate group from ATP to NAD to generate NADP, which in its reduced form acts as an electron donor for biosynthetic reactions (Lerner et al., 2001 [PubMed 11594753]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)6.12036896
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.12036896
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.08204932
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.92517711
5positive regulation by organism of defense response of other organism involved in symbiotic interact5.92517711
6modulation by symbiont of host immune response (GO:0052553)5.92517711
7positive regulation by symbiont of host defense response (GO:0052509)5.92517711
8modulation by symbiont of host defense response (GO:0052031)5.92517711
9modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.92517711
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.55717191
11positive regulation of gamma-delta T cell activation (GO:0046645)5.55615071
12antigen processing and presentation of endogenous antigen (GO:0019883)5.40733894
13L-phenylalanine catabolic process (GO:0006559)5.35563629
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.35563629
15L-phenylalanine metabolic process (GO:0006558)5.34262238
16erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.34262238
17detection of other organism (GO:0098543)5.23852586
18alpha-linolenic acid metabolic process (GO:0036109)5.23378534
19neutrophil activation involved in immune response (GO:0002283)5.15297269
20antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.05640262
21triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.01365391
22detection of bacterium (GO:0016045)5.00214377
23response to peptidoglycan (GO:0032494)4.98074565
24macrophage activation involved in immune response (GO:0002281)4.96000272
25cysteine metabolic process (GO:0006534)4.89666471
26sulfur amino acid catabolic process (GO:0000098)4.83248091
27aromatic amino acid family catabolic process (GO:0009074)4.78585827
28detection of molecule of bacterial origin (GO:0032490)4.64338442
29detection of external biotic stimulus (GO:0098581)4.62402712
30complement activation, alternative pathway (GO:0006957)4.50884504
31urea cycle (GO:0000050)4.48953260
32urea metabolic process (GO:0019627)4.48953260
33fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.40192296
34glyoxylate metabolic process (GO:0046487)4.37965727
35regulation of B cell receptor signaling pathway (GO:0050855)4.36630779
36kynurenine metabolic process (GO:0070189)4.33275309
37negative regulation of interleukin-12 production (GO:0032695)4.33086532
38negative regulation of fibrinolysis (GO:0051918)4.32456888
39bile acid biosynthetic process (GO:0006699)4.29834935
40tryptophan catabolic process (GO:0006569)4.29319595
41indole-containing compound catabolic process (GO:0042436)4.29319595
42indolalkylamine catabolic process (GO:0046218)4.29319595
43peptidyl-glutamic acid carboxylation (GO:0017187)4.29005110
44protein carboxylation (GO:0018214)4.29005110
45leukocyte aggregation (GO:0070486)4.28610509
46plasma lipoprotein particle clearance (GO:0034381)4.27876643
47regulation of interferon-beta biosynthetic process (GO:0045357)4.27150188
48low-density lipoprotein particle clearance (GO:0034383)4.26133940
49cellular extravasation (GO:0045123)4.24945124
50lysine catabolic process (GO:0006554)4.15323187
51lysine metabolic process (GO:0006553)4.15323187
52respiratory burst (GO:0045730)4.11742232
53regulation of triglyceride catabolic process (GO:0010896)4.11667162
54leukocyte migration involved in inflammatory response (GO:0002523)4.10505640
55nitrogen cycle metabolic process (GO:0071941)4.09764003
56high-density lipoprotein particle remodeling (GO:0034375)4.09453411
57positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.09247512
58regulation of protein activation cascade (GO:2000257)4.08708183
59serine family amino acid catabolic process (GO:0009071)4.07320730
60homocysteine metabolic process (GO:0050667)4.06133477
61negative regulation of lymphocyte mediated immunity (GO:0002707)4.05774689
62tryptophan metabolic process (GO:0006568)4.04468538
63response to host immune response (GO:0052572)4.03495969
64response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.03495969
65detection of biotic stimulus (GO:0009595)4.02899202
66neutrophil activation (GO:0042119)4.00186738
67regulation of gamma-delta T cell activation (GO:0046643)3.98612097
68amino-acid betaine metabolic process (GO:0006577)3.96595345
69glycine metabolic process (GO:0006544)3.89719351
70regulation of complement activation (GO:0030449)3.89158833
71immunoglobulin mediated immune response (GO:0016064)3.83827281
72regulation of fibrinolysis (GO:0051917)3.80579208
73reverse cholesterol transport (GO:0043691)3.80290001
74response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.78724224
75response to host (GO:0075136)3.78724224
76response to host defenses (GO:0052200)3.78724224
77serine family amino acid biosynthetic process (GO:0009070)3.77313362
78serine family amino acid metabolic process (GO:0009069)3.77245236
79positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.74377841
80regulation of mast cell degranulation (GO:0043304)3.74334416
81negative regulation of erythrocyte differentiation (GO:0045647)3.73307019
82bile acid metabolic process (GO:0008206)3.72529354
83negative regulation of sterol transport (GO:0032372)3.71661176
84negative regulation of cholesterol transport (GO:0032375)3.71661176
85plasma lipoprotein particle remodeling (GO:0034369)3.70388492
86protein-lipid complex remodeling (GO:0034368)3.70388492
87macromolecular complex remodeling (GO:0034367)3.70388492
88cellular response to type I interferon (GO:0071357)3.70178022
89type I interferon signaling pathway (GO:0060337)3.70178022
90granulocyte activation (GO:0036230)3.69404834
91response to type I interferon (GO:0034340)3.67451406
92negative regulation of leukocyte mediated immunity (GO:0002704)3.66085720
93response to interleukin-15 (GO:0070672)3.65787963
94valine metabolic process (GO:0006573)3.64204789
95microglial cell activation (GO:0001774)3.61172246
96regulation of cholesterol homeostasis (GO:2000188)3.58835893
97ethanol oxidation (GO:0006069)3.58359479
98acylglycerol homeostasis (GO:0055090)3.57315793
99triglyceride homeostasis (GO:0070328)3.57315793
100phospholipid efflux (GO:0033700)3.55378651
101regulation of myeloid leukocyte mediated immunity (GO:0002886)3.55167017
102macrophage activation (GO:0042116)3.55131893
103production of molecular mediator involved in inflammatory response (GO:0002532)3.53095647
104regulation of cholesterol esterification (GO:0010872)3.52081255
105antigen processing and presentation via MHC class Ib (GO:0002475)3.51637202
106positive regulation of lipid catabolic process (GO:0050996)3.49969457
107myeloid cell activation involved in immune response (GO:0002275)3.49014483
108alpha-amino acid catabolic process (GO:1901606)3.48227455
109aromatic amino acid family metabolic process (GO:0009072)3.47650742
110regulation of leukocyte degranulation (GO:0043300)3.44540205
111regulation of gamma-delta T cell differentiation (GO:0045586)3.43436046
112plasma lipoprotein particle assembly (GO:0034377)3.41755910
113regulation of mast cell activation involved in immune response (GO:0033006)3.38701788
114response to muramyl dipeptide (GO:0032495)3.37625476
115positive regulation of fatty acid beta-oxidation (GO:0032000)3.36423620
116regulation of cholesterol storage (GO:0010885)3.36173350
117cellular modified amino acid catabolic process (GO:0042219)3.34898074
118phospholipid homeostasis (GO:0055091)3.34728622
119B cell receptor signaling pathway (GO:0050853)3.32943148
120neutrophil mediated immunity (GO:0002446)3.32910779
121acetyl-CoA metabolic process (GO:0006084)3.32503012
122positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.32111149
123cellular amino acid catabolic process (GO:0009063)3.29799141
124negative regulation of T cell mediated immunity (GO:0002710)3.29423751
125positive regulation of lipoprotein lipase activity (GO:0051006)3.27971069
126positive regulation of triglyceride lipase activity (GO:0061365)3.27971069
127negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.27835839
128disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.27466844
129killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.27466844
130fatty acid beta-oxidation (GO:0006635)3.26559781
131aldehyde catabolic process (GO:0046185)3.25989781
132positive regulation of triglyceride metabolic process (GO:0090208)3.24900390
133negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.24530277
134imidazole-containing compound metabolic process (GO:0052803)3.22787925
135fatty acid oxidation (GO:0019395)3.22289881
1362-oxoglutarate metabolic process (GO:0006103)3.21480242
137germinal center formation (GO:0002467)3.20929015
138tyrosine metabolic process (GO:0006570)3.20880432
139protein-lipid complex assembly (GO:0065005)3.20702257
140cellular response to interleukin-15 (GO:0071350)3.20652299
141fibrinolysis (GO:0042730)3.18913952
142lipopolysaccharide-mediated signaling pathway (GO:0031663)3.18372328
143lipid oxidation (GO:0034440)3.17896147
144bile acid and bile salt transport (GO:0015721)3.17269774
145cholesterol homeostasis (GO:0042632)3.16646516
146cholesterol efflux (GO:0033344)3.16218844
147regulation of T cell tolerance induction (GO:0002664)3.15960203
148sterol homeostasis (GO:0055092)3.14014231
149positive regulation of mast cell activation (GO:0033005)3.12751156
150regulation of T-helper 2 cell differentiation (GO:0045628)3.12701720
151carnitine metabolic process (GO:0009437)3.12282563
152regulation of tolerance induction (GO:0002643)3.11447846
153regulation of fatty acid beta-oxidation (GO:0031998)3.11115064
154L-serine metabolic process (GO:0006563)3.10833891
155lipoprotein metabolic process (GO:0042157)3.10536322
156benzene-containing compound metabolic process (GO:0042537)3.08661623
157cellular glucuronidation (GO:0052695)3.08640461
158pentose-phosphate shunt (GO:0006098)3.07981588
159plasma lipoprotein particle organization (GO:0071827)3.07635495
160defense response to protozoan (GO:0042832)3.07625264
161negative regulation of phagocytosis (GO:0050765)3.07603525
162interferon-gamma-mediated signaling pathway (GO:0060333)3.06821852
163very-low-density lipoprotein particle assembly (GO:0034379)3.06699924
164cellular ketone body metabolic process (GO:0046950)3.06379391
165urate metabolic process (GO:0046415)3.05616520
166regulation of dendritic cell antigen processing and presentation (GO:0002604)3.05183452
167NADPH regeneration (GO:0006740)3.04004627
168positive regulation of cellular amide metabolic process (GO:0034250)3.03532935
169positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.02066915
170ethanol metabolic process (GO:0006067)3.01345410
171regulation of mast cell activation (GO:0033003)3.01037127
172regulation of B cell differentiation (GO:0045577)3.00936518
173carboxylic acid catabolic process (GO:0046395)3.00915389
174organic acid catabolic process (GO:0016054)3.00915389
175glutamate metabolic process (GO:0006536)3.00646012
176fatty acid catabolic process (GO:0009062)3.00280118
177low-density lipoprotein particle remodeling (GO:0034374)3.00190273
178response to nitrosative stress (GO:0051409)2.99165565
179positive regulation of B cell differentiation (GO:0045579)2.97324039
180positive regulation of interferon-alpha production (GO:0032727)2.97129343
181B cell mediated immunity (GO:0019724)2.95923794
182regulation of regulated secretory pathway (GO:1903305)2.95654689
183negative regulation of innate immune response (GO:0045824)2.95385321
184leukocyte degranulation (GO:0043299)2.88896866
185negative regulation of type 2 immune response (GO:0002829)2.88873742
186regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.88185306
187negative regulation of toll-like receptor signaling pathway (GO:0034122)2.86806591
188positive thymic T cell selection (GO:0045059)2.85585737
189negative regulation of interleukin-6 production (GO:0032715)2.84496328
190myeloid leukocyte mediated immunity (GO:0002444)2.83745116
191positive regulation of Cdc42 GTPase activity (GO:0043089)2.81989744
192negative regulation of cytokine production involved in immune response (GO:0002719)2.81396934
193regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.79939915
194dendritic cell chemotaxis (GO:0002407)2.78965365
195regulation of interferon-alpha production (GO:0032647)2.76255232
196positive regulation of mast cell activation involved in immune response (GO:0033008)2.75791187
197positive regulation of mast cell degranulation (GO:0043306)2.75791187
198dendritic cell migration (GO:0036336)2.72493694
199regulation of T cell mediated cytotoxicity (GO:0001914)2.71876319
200response to protozoan (GO:0001562)2.71314874

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.86272845
2* RXR_22158963_ChIP-Seq_LIVER_Mouse5.55179119
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.37364475
4PPARA_22158963_ChIP-Seq_LIVER_Mouse5.07523755
5* LXR_22158963_ChIP-Seq_LIVER_Mouse4.28524740
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.01099191
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.44640622
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.18740384
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.73480645
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.70656769
11* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.56049646
12CLOCK_20551151_ChIP-Seq_293T_Human2.41495324
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.40554492
14* SPI1_23127762_ChIP-Seq_K562_Human2.31743650
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.28313593
16* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.27517611
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.11191120
18STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.05830740
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.02352072
20KDM2B_26808549_Chip-Seq_DND41_Human2.00602750
21STAT4_19710469_ChIP-ChIP_TH1__Mouse1.99417303
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.97686026
23SCL_19346495_ChIP-Seq_HPC-7_Human1.97663885
24RUNX_20019798_ChIP-Seq_JUKART_Human1.97373528
25IRF8_22096565_ChIP-ChIP_GC-B_Human1.95743036
26VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.95475578
27RARG_19884340_ChIP-ChIP_MEFs_Mouse1.89431789
28TP63_17297297_ChIP-ChIP_HaCaT_Human1.84341815
29MYB_26560356_Chip-Seq_TH2_Human1.82423856
30FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.79242506
31* MAF_26560356_Chip-Seq_TH2_Human1.78885424
32HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.77234506
33STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.69815168
34MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.69428508
35IRF8_21731497_ChIP-ChIP_J774_Mouse1.69346687
36* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.68272617
37EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.63893016
38* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.62392915
39TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.60156218
40RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.59770903
41GATA1_19941827_ChIP-Seq_MEL_Mouse1.56801863
42TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.55576754
43STAT6_21828071_ChIP-Seq_BEAS2B_Human1.54720335
44EGR1_19374776_ChIP-ChIP_THP-1_Human1.54141621
45STAT3_1855785_ChIP-Seq_MESCs_Mouse1.52454294
46* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.50873268
47BRD4_27068464_Chip-Seq_AML-cells_Mouse1.48703247
48LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.38847019
49* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.38524118
50PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36779042
51* KDM2B_26808549_Chip-Seq_JURKAT_Human1.35601011
52* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.35214148
53VDR_24787735_ChIP-Seq_THP-1_Human1.35172736
54IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.34048841
55* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.32481956
56CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.31223831
57* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.30056859
58Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.29215595
59IRF8_27001747_Chip-Seq_BMDM_Mouse1.28407466
60CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.24526912
61GATA3_27048872_Chip-Seq_THYMUS_Human1.22534945
62ESR1_15608294_ChIP-ChIP_MCF-7_Human1.21860095
63ELK3_25401928_ChIP-Seq_HUVEC_Human1.21419458
64THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.20699815
65CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20476324
66PU.1_20513432_ChIP-Seq_Bcells_Mouse1.20460869
67GATA1_19941826_ChIP-Seq_K562_Human1.20077366
68SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19469870
69PU_27001747_Chip-Seq_BMDM_Mouse1.19006634
70GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18801168
71ZNF263_19887448_ChIP-Seq_K562_Human1.17662303
72* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.16985956
73POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.14709054
74MYC_22102868_ChIP-Seq_BL_Human1.14575682
75* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14172309
76GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.13684818
77AR_21909140_ChIP-Seq_LNCAP_Human1.13614996
78SOX2_27498859_Chip-Seq_STOMACH_Mouse1.13346391
79GATA1_22025678_ChIP-Seq_K562_Human1.11853407
80CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11051500
81* KDM2B_26808549_Chip-Seq_K562_Human1.10271403
82* VDR_21846776_ChIP-Seq_THP-1_Human1.10190592
83* LXR_22292898_ChIP-Seq_THP-1_Human1.10012509
84SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.07677401
85ATF3_27146783_Chip-Seq_COLON_Human1.07072521
86* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.06675717
87* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.05714408
88* SA1_27219007_Chip-Seq_ERYTHROID_Human1.05389246
89SMAD_19615063_ChIP-ChIP_OVARY_Human1.03953883
90TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03847004
91* RACK7_27058665_Chip-Seq_MCF-7_Human1.03819028
92* GATA4_25053715_ChIP-Seq_YYC3_Human1.03363837
93SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.02827080
94LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.02664506
95RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.97486415
96* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.96896807
97SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.96625370
98ESR2_21235772_ChIP-Seq_MCF-7_Human0.95485227
99* P68_20966046_ChIP-Seq_HELA_Human0.95109307
100* HNF4A_19822575_ChIP-Seq_HepG2_Human0.94533433
101* FOXA2_19822575_ChIP-Seq_HepG2_Human0.94254316
102GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93963059
103SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93718091
104GATA2_21666600_ChIP-Seq_HMVEC_Human0.93284232
105IKZF1_21737484_ChIP-ChIP_HCT116_Human0.93029090
106* MAF_26560356_Chip-Seq_TH1_Human0.92419720
107ELF1_20517297_ChIP-Seq_JURKAT_Human0.91203734
108ELF1_17652178_ChIP-ChIP_JURKAT_Human0.90351023
109SMC4_20622854_ChIP-Seq_HELA_Human0.90155048
110RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89674418
111GATA6_25053715_ChIP-Seq_YYC3_Human0.87251783
112SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.86518291
113* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.84499177
114CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83436329
115* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.83420955
116RXRA_24833708_ChIP-Seq_LIVER_Mouse0.83405653
117* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.83230192
118* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.82721646
119HIF1A_21447827_ChIP-Seq_MCF-7_Human0.82175082
120TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.82044778
121* FOXO3_23340844_ChIP-Seq_DLD1_Human0.81550032
122RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.81299228
123CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.81196722
124BCOR_27268052_Chip-Seq_Bcells_Human0.81128236
125* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.79787087
126* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.79663153
127PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.79271087
128ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.78561888
129SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.78244015
130RUNX1_22412390_ChIP-Seq_EML_Mouse0.78206747
131PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.78001262
132* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.77457233
133PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.76506199
134* UTX_26944678_Chip-Seq_JUKART_Human0.75475318
135GATA2_22383799_ChIP-Seq_G1ME_Mouse0.75209205
136SPI1_23547873_ChIP-Seq_NB4_Human0.75109335
137ESR1_21235772_ChIP-Seq_MCF-7_Human0.75023539
138* IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.74659693
139* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.74242934
140TCF7_22412390_ChIP-Seq_EML_Mouse0.73772419
141* VDR_24763502_ChIP-Seq_THP-1_Human0.73607150
142ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.72764545
143MYB_26560356_Chip-Seq_TH1_Human0.71793172
144BCL6_27268052_Chip-Seq_Bcells_Human0.71770056
145E2F7_22180533_ChIP-Seq_HELA_Human0.71696702
146NCOR1_26117541_ChIP-Seq_K562_Human0.71380246
147BP1_19119308_ChIP-ChIP_Hs578T_Human0.71165294
148SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.70198578
149PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.68714826
150* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.68685034

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.78946783
2MP0005360_urolithiasis5.62002880
3MP0005365_abnormal_bile_salt4.35705888
4MP0005085_abnormal_gallbladder_physiolo4.10649594
5MP0009840_abnormal_foam_cell3.55230058
6MP0003806_abnormal_nucleotide_metabolis3.51271037
7MP0008875_abnormal_xenobiotic_pharmacok3.30887829
8MP0010329_abnormal_lipoprotein_level2.88213963
9MP0003191_abnormal_cellular_cholesterol2.61417412
10MP0003252_abnormal_bile_duct2.57269352
11MP0005671_abnormal_response_to2.49912451
12MP0003705_abnormal_hypodermis_morpholog2.47843946
13MP0002723_abnormal_immune_serum2.41345091
14MP0008260_abnormal_autophagy2.38062915
15MP0002420_abnormal_adaptive_immunity2.36234787
16MP0001819_abnormal_immune_cell2.34299590
17MP0005083_abnormal_biliary_tract2.31527766
18MP0005332_abnormal_amino_acid2.24144630
19MP0001666_abnormal_nutrient_absorption2.14898567
20MP0002148_abnormal_hypersensitivity_rea2.10303514
21MP0003172_abnormal_lysosome_physiology2.03960055
22MP0000609_abnormal_liver_physiology2.02576032
23MP0003763_abnormal_thymus_physiology1.91018366
24MP0003436_decreased_susceptibility_to1.86291358
25MP0003195_calcinosis1.81971906
26MP0003828_pulmonary_edema1.80597175
27MP0002398_abnormal_bone_marrow1.80259824
28MP0003186_abnormal_redox_activity1.77847899
29MP0002132_abnormal_respiratory_system1.77117053
30MP0000716_abnormal_immune_system1.76652560
31MP0002118_abnormal_lipid_homeostasis1.75892358
32MP0002138_abnormal_hepatobiliary_system1.75810665
33MP0004019_abnormal_vitamin_homeostasis1.73420139
34MP0005319_abnormal_enzyme/_coenzyme1.69384140
35MP0009333_abnormal_splenocyte_physiolog1.63966085
36MP0003183_abnormal_peptide_metabolism1.62644078
37MP0002396_abnormal_hematopoietic_system1.60546143
38MP0005670_abnormal_white_adipose1.51845632
39MP0002722_abnormal_immune_system1.48632622
40MP0000689_abnormal_spleen_morphology1.45540274
41MP0003866_abnormal_defecation1.43475923
42MP0002429_abnormal_blood_cell1.43394319
43MP0000465_gastrointestinal_hemorrhage1.40977547
44MP0005058_abnormal_lysosome_morphology1.39512918
45MP0009643_abnormal_urine_homeostasis1.39442779
46MP0008438_abnormal_cutaneous_collagen1.36363441
47MP0003303_peritoneal_inflammation1.35381756
48MP0005584_abnormal_enzyme/coenzyme_acti1.33258811
49MP0004883_abnormal_blood_vessel1.33048526
50MP0003300_gastrointestinal_ulcer1.30981844
51MP0000703_abnormal_thymus_morphology1.29688701
52MP0002254_reproductive_system_inflammat1.29567049
53MP0002998_abnormal_bone_remodeling1.29556309
54MP0003724_increased_susceptibility_to1.29550654
55MP0004510_myositis1.29398404
56MP0000604_amyloidosis1.28418302
57MP0001764_abnormal_homeostasis1.28335762
58MP0009764_decreased_sensitivity_to1.25723850
59MP0005310_abnormal_salivary_gland1.25443859
60MP0000598_abnormal_liver_morphology1.24431708
61MP0004381_abnormal_hair_follicle1.23752758
62MP0008469_abnormal_protein_level1.21254134
63MP0009785_altered_susceptibility_to1.19631845
64MP0001851_eye_inflammation1.18367734
65MP0003656_abnormal_erythrocyte_physiolo1.18220330
66MP0002277_abnormal_respiratory_mucosa1.17998871
67MP0005023_abnormal_wound_healing1.14940386
68MP0001853_heart_inflammation1.13638549
69MP0009763_increased_sensitivity_to1.13113595
70MP0005666_abnormal_adipose_tissue1.12487182
71MP0005464_abnormal_platelet_physiology1.12029719
72MP0005451_abnormal_body_composition1.12019671
73MP0002419_abnormal_innate_immunity1.11286428
74MP0004858_abnormal_nervous_system1.07789185
75MP0010352_gastrointestinal_tract_polyps1.06838992
76MP0003566_abnormal_cell_adhesion1.04124194
77MP0010234_abnormal_vibrissa_follicle1.04080434
78MP0004130_abnormal_muscle_cell1.00630046
79MP0001533_abnormal_skeleton_physiology1.00148927
80MP0004185_abnormal_adipocyte_glucose0.99929985
81MP0002166_altered_tumor_susceptibility0.99702933
82MP0003448_altered_tumor_morphology0.98841248
83MP0000685_abnormal_immune_system0.98586394
84MP0004947_skin_inflammation0.97823275
85MP0005025_abnormal_response_to0.97461289
86MP0000490_abnormal_crypts_of0.94629289
87MP0001845_abnormal_inflammatory_respons0.93133284
88MP0002971_abnormal_brown_adipose0.93069921
89MP0005076_abnormal_cell_differentiation0.92491721
90MP0005390_skeleton_phenotype0.91979437
91MP0003075_altered_response_to0.89566700
92MP0008004_abnormal_stomach_pH0.87725089
93MP0001835_abnormal_antigen_presentation0.87416549
94MP0000343_altered_response_to0.87125552
95MP0001663_abnormal_digestive_system0.87018417
96MP0006082_CNS_inflammation0.86677362
97MP0003868_abnormal_feces_composition0.86605343
98MP0003011_delayed_dark_adaptation0.84969292
99MP0003453_abnormal_keratinocyte_physiol0.84958215
100MP0009278_abnormal_bone_marrow0.84862866
101MP0004808_abnormal_hematopoietic_stem0.83821650
102MP0002136_abnormal_kidney_physiology0.81863412
103MP0003091_abnormal_cell_migration0.81571157
104MP0001545_abnormal_hematopoietic_system0.79371662
105MP0005397_hematopoietic_system_phenotyp0.79371662
106MP0001756_abnormal_urination0.78009484
107MP0005636_abnormal_mineral_homeostasis0.77863748
108MP0001873_stomach_inflammation0.77450148
109MP0001661_extended_life_span0.76959444
110MP0009642_abnormal_blood_homeostasis0.75986387
111MP0000858_altered_metastatic_potential0.75584566
112MP0010155_abnormal_intestine_physiology0.74441531
113MP0001881_abnormal_mammary_gland0.74413381
114MP0003690_abnormal_glial_cell0.73116338
115MP0005334_abnormal_fat_pad0.72458732
116MP0005167_abnormal_blood-brain_barrier0.71758045
117MP0009765_abnormal_xenobiotic_induced0.70698909
118MP0005647_abnormal_sex_gland0.70391599
119MP0005376_homeostasis/metabolism_phenot0.69833388
120MP0005275_abnormal_skin_tensile0.69792579
121MP0000249_abnormal_blood_vessel0.69073271
122MP0002060_abnormal_skin_morphology0.68907205
123MP0005164_abnormal_response_to0.68727976
124MP0003795_abnormal_bone_structure0.68671916
125MP0005166_decreased_susceptibility_to0.68521583
126MP0009115_abnormal_fat_cell0.68387290
127MP0003221_abnormal_cardiomyocyte_apopto0.67200790
128MP0008874_decreased_physiological_sensi0.66449281
129MP0005000_abnormal_immune_tolerance0.65737128
130MP0001958_emphysema0.65537176
131MP0003045_fibrosis0.65513369
132MP0009053_abnormal_anal_canal0.65055218
133MP0005387_immune_system_phenotype0.63974439
134MP0001790_abnormal_immune_system0.63974439
135MP0002796_impaired_skin_barrier0.63790197
136MP0008873_increased_physiological_sensi0.63741993
137MP0004782_abnormal_surfactant_physiolog0.63598991
138MP0001800_abnormal_humoral_immune0.63079196
139MP0002933_joint_inflammation0.62288547
140MP0005375_adipose_tissue_phenotype0.62141856
141MP0002452_abnormal_antigen_presenting0.61070106
142MP0001849_ear_inflammation0.60705888
143MP0003329_amyloid_beta_deposits0.60246158
144MP0002405_respiratory_system_inflammati0.60105390
145MP0006036_abnormal_mitochondrial_physio0.59854563
146MP0001243_abnormal_dermal_layer0.59287494
147MP0000015_abnormal_ear_pigmentation0.58853137
148MP0002877_abnormal_melanocyte_morpholog0.58159874

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.78182091
2Myositis (HP:0100614)5.39350110
3Xanthomatosis (HP:0000991)5.33981720
4Orchitis (HP:0100796)5.20141830
5Intrahepatic cholestasis (HP:0001406)5.18731666
6Abnormality of aromatic amino acid family metabolism (HP:0004338)5.15825663
7Abnormality of monocarboxylic acid metabolism (HP:0010996)5.14467709
8Hypobetalipoproteinemia (HP:0003563)4.74060961
9Retrobulbar optic neuritis (HP:0100654)4.73702703
10Optic neuritis (HP:0100653)4.73702703
11Complement deficiency (HP:0004431)4.56555850
12Hyperlipoproteinemia (HP:0010980)4.33533789
13Gastrointestinal infarctions (HP:0005244)4.16194768
14Prolonged partial thromboplastin time (HP:0003645)4.06270969
15Chronic obstructive pulmonary disease (HP:0006510)4.05950630
16Obstructive lung disease (HP:0006536)4.05950630
17Hyperammonemia (HP:0001987)4.00237191
18Elevated erythrocyte sedimentation rate (HP:0003565)3.99083185
19Mediastinal lymphadenopathy (HP:0100721)3.98255246
20Hyperglycinuria (HP:0003108)3.95050842
21Hypolipoproteinemia (HP:0010981)3.84702668
22Abnormality of glutamine family amino acid metabolism (HP:0010902)3.84469414
23Stomatitis (HP:0010280)3.84451565
24Recurrent fungal infections (HP:0002841)3.80983760
25Meningitis (HP:0001287)3.80078371
26Abnormality of complement system (HP:0005339)3.76033985
27Abnormality of glycine metabolism (HP:0010895)3.72615058
28Abnormality of serine family amino acid metabolism (HP:0010894)3.72615058
29Gingivitis (HP:0000230)3.71140659
30Recurrent skin infections (HP:0001581)3.70625835
31Abnormality of the common coagulation pathway (HP:0010990)3.65518489
32Hyperglycinemia (HP:0002154)3.62120871
33Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.60305704
34Joint hemorrhage (HP:0005261)3.56637471
35Hypoalphalipoproteinemia (HP:0003233)3.54955378
36Abnormality of sulfur amino acid metabolism (HP:0004339)3.53525174
37Cellulitis (HP:0100658)3.53327819
38Spontaneous hematomas (HP:0007420)3.50034686
39Recurrent gram-negative bacterial infections (HP:0005420)3.49917520
40Keratoconjunctivitis sicca (HP:0001097)3.48714421
41Myocardial infarction (HP:0001658)3.47581277
42Increased IgE level (HP:0003212)3.45953943
43Epidermoid cyst (HP:0200040)3.43717878
44Abnormal delayed hypersensitivity skin test (HP:0002963)3.40918467
45Encephalitis (HP:0002383)3.30402032
46Ketosis (HP:0001946)3.29915224
47Systemic lupus erythematosus (HP:0002725)3.28336444
48Vasculitis (HP:0002633)3.25878559
49Hypoglycemic coma (HP:0001325)3.24434273
50Abnormality of fatty-acid metabolism (HP:0004359)3.19009127
51Recurrent cutaneous fungal infections (HP:0011370)3.16688897
52Chronic mucocutaneous candidiasis (HP:0002728)3.16688897
53Keratoconjunctivitis (HP:0001096)3.12630397
54Fat malabsorption (HP:0002630)3.12257221
55Abnormality of pyrimidine metabolism (HP:0004353)3.12245719
56Abnormality of aspartate family amino acid metabolism (HP:0010899)3.09030369
57Hypercholesterolemia (HP:0003124)3.01602147
58Hypochromic microcytic anemia (HP:0004840)3.00629599
59Prolonged bleeding time (HP:0003010)2.98812203
60Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.97250552
61Hypochromic anemia (HP:0001931)2.89444249
62Abnormality of methionine metabolism (HP:0010901)2.88521082
63Chest pain (HP:0100749)2.88399141
64Abnormality of nucleobase metabolism (HP:0010932)2.87412091
65Abnormality of the intrinsic pathway (HP:0010989)2.85537607
66Esophageal varix (HP:0002040)2.76988493
67Episodic fever (HP:0001954)2.75708103
68Spastic diplegia (HP:0001264)2.75603006
69Abnormality of purine metabolism (HP:0004352)2.74995276
70Hemoptysis (HP:0002105)2.74295351
71Gastrointestinal inflammation (HP:0004386)2.70887779
72Inflammation of the large intestine (HP:0002037)2.70303579
73Pulmonary infiltrates (HP:0002113)2.67952128
74Arterial thrombosis (HP:0004420)2.67094870
75Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.64719959
76Recurrent viral infections (HP:0004429)2.64523881
77Glomerulonephritis (HP:0000099)2.58026449
78Osteomyelitis (HP:0002754)2.57566797
79Epistaxis (HP:0000421)2.55212892
80Pulmonary embolism (HP:0002204)2.52846148
81Anorexia (HP:0002039)2.51856952
82Abnormality of proline metabolism (HP:0010907)2.48875183
83Hydroxyprolinuria (HP:0003080)2.48875183
84Colitis (HP:0002583)2.47697293
85Abnormality of serum amino acid levels (HP:0003112)2.47498064
86Hepatocellular carcinoma (HP:0001402)2.44163054
87Abnormality of the peritoneum (HP:0002585)2.42394663
88Petechiae (HP:0000967)2.41422086
89Steatorrhea (HP:0002570)2.41189159
90Peritonitis (HP:0002586)2.39797316
91Skin nodule (HP:0200036)2.38648676
92T lymphocytopenia (HP:0005403)2.38031917
93Dicarboxylic aciduria (HP:0003215)2.37370195
94Abnormality of dicarboxylic acid metabolism (HP:0010995)2.37370195
95Ketoacidosis (HP:0001993)2.36329684
96Purpura (HP:0000979)2.35932221
97Gout (HP:0001997)2.35571108
98Eczematoid dermatitis (HP:0000976)2.34274379
99Abnormality of iron homeostasis (HP:0011031)2.32629044
100Leukocytosis (HP:0001974)2.32538261
101Hyperbilirubinemia (HP:0002904)2.31196130
102Abnormal cartilage morphology (HP:0002763)2.29137567
103Increased IgM level (HP:0003496)2.28692942
104Nausea (HP:0002018)2.28451523
105Vascular calcification (HP:0004934)2.28319665
106Pustule (HP:0200039)2.27339262
107Malnutrition (HP:0004395)2.26514488
108Amyloidosis (HP:0011034)2.26143885
109Abnormality of glycolipid metabolism (HP:0010969)2.25822241
110Abnormality of liposaccharide metabolism (HP:0010968)2.25822241
111Abnormality of glycosphingolipid metabolism (HP:0004343)2.25822241
112Abnormality of T cell number (HP:0011839)2.25586986
113Abnormality of transition element cation homeostasis (HP:0011030)2.24462302
114Loss of speech (HP:0002371)2.23519988
115Hypertriglyceridemia (HP:0002155)2.23362430
116Conjugated hyperbilirubinemia (HP:0002908)2.22323324
117Pancreatitis (HP:0001733)2.21829925
118Sepsis (HP:0100806)2.21325913
119Increased cerebral lipofuscin (HP:0011813)2.18266751
120Cardiovascular calcification (HP:0011915)2.18071887
121Nephritis (HP:0000123)2.17083570
122Gingival bleeding (HP:0000225)2.16499865
123Vacuolated lymphocytes (HP:0001922)2.16406961
124Hepatosplenomegaly (HP:0001433)2.16182628
125Increased serum ferritin (HP:0003281)2.15631533
126Delayed CNS myelination (HP:0002188)2.14508990
127Microcytic anemia (HP:0001935)2.14162319
128Granulocytopenia (HP:0001913)2.13578135
129Hemorrhage of the eye (HP:0011885)2.12220682
130Abnormality of the pleura (HP:0002103)2.10991392
131Metabolic acidosis (HP:0001942)2.10601563
132Gangrene (HP:0100758)2.07678840
133Slow saccadic eye movements (HP:0000514)2.07372367
134Glomerulopathy (HP:0100820)2.06960707
135Abnormality of T cells (HP:0002843)2.06717763
136Skin ulcer (HP:0200042)2.06460641
137Lymphopenia (HP:0001888)2.06242518
138Hypergammaglobulinemia (HP:0010702)2.05828522
139Abnormality of the endocardium (HP:0004306)2.02702275
140Recurrent bacterial skin infections (HP:0005406)2.02438623
141Panhypogammaglobulinemia (HP:0003139)2.02224769
142Acne (HP:0001061)2.01401086
143Premature loss of primary teeth (HP:0006323)1.99738072
144Segmental peripheral demyelination/remyelination (HP:0003481)1.99673716
145Polycythemia (HP:0001901)1.99371774
146Axonal loss (HP:0003447)1.99253427
147Metaphyseal cupping (HP:0003021)1.98417561
148Mitral stenosis (HP:0001718)1.98124469
149Abnormality of cells of the lymphoid lineage (HP:0012140)1.98050931
150Gastrointestinal stroma tumor (HP:0100723)1.97858516
151Lethargy (HP:0001254)1.97025123
152Viral hepatitis (HP:0006562)1.96414100
153Generalized aminoaciduria (HP:0002909)1.95814818
154Thrombophlebitis (HP:0004418)1.95434275
155Increased mean platelet volume (HP:0011877)1.94367752
156Abnormal enzyme/coenzyme activity (HP:0012379)1.88978472
157Recurrent pneumonia (HP:0006532)1.88882194
158Irritability (HP:0000737)1.88813091
159Acute hepatic failure (HP:0006554)1.87129349
160Late onset (HP:0003584)1.86295824
161Subacute progressive viral hepatitis (HP:0006572)1.84751949
162Nasal polyposis (HP:0100582)1.84371233
163Dysostosis multiplex (HP:0000943)1.83568629
164Abnormal platelet volume (HP:0011876)1.82961031
165Multiple enchondromatosis (HP:0005701)1.82902920
166Abnormality of the pericardium (HP:0001697)1.82491631
167Agammaglobulinemia (HP:0004432)1.82444156
168Interstitial pulmonary disease (HP:0006530)1.82156558
169Abnormality of macrophages (HP:0004311)1.81609787
170Spontaneous abortion (HP:0005268)1.81076570
171Menorrhagia (HP:0000132)1.80849344
172Urticaria (HP:0001025)1.80207274
173Autoimmune thrombocytopenia (HP:0001973)1.78442051
174Neonatal onset (HP:0003623)1.77511109
175Cholelithiasis (HP:0001081)1.76055763
176Opisthotonus (HP:0002179)1.74895499
177Sensorimotor neuropathy (HP:0007141)1.74779909
178Abnormality of the Achilles tendon (HP:0005109)1.73736582
179Vomiting (HP:0002013)1.72173222
180Recurrent abscess formation (HP:0002722)1.70920619
181Abnormal gallbladder morphology (HP:0012437)1.69794002
182Proximal tubulopathy (HP:0000114)1.68574226
183Abnormality of alkaline phosphatase activity (HP:0004379)1.68361356

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.62386473
2ERN14.44986075
3TRIB34.23300740
4BCKDK3.86481380
5PKN23.10418929
6SIK12.84246277
7PRPF4B2.74909038
8FGFR42.69026079
9TYK22.17071413
10FES2.08962773
11TNK21.99185908
12PTK61.85272981
13EPHB11.82952687
14TBK11.76542772
15MAP2K31.69277953
16FLT31.65812872
17SMG11.61562136
18TESK21.59653753
19LRRK21.59093722
20EEF2K1.58539453
21STK101.57243378
22EPHA21.56805162
23KDR1.54686962
24TAOK31.48195189
25MAP4K11.44930414
26MAP3K131.44239120
27MAP3K31.41097983
28MST1R1.40930360
29RIPK11.39203428
30CSK1.38759675
31MAP3K11.37121506
32SYK1.33343879
33CAMK1D1.32761405
34NEK91.32579494
35IRAK31.31420756
36MAP3K101.27509371
37MAP3K141.26213256
38BLK1.23402164
39GRK61.21445860
40TTN1.19109799
41LYN1.17423547
42MARK21.14776206
43LATS11.14144644
44TGFBR21.12964664
45RPS6KA41.12950878
46JAK31.12949698
47YES11.11492554
48PAK41.09717408
49ABL21.08904994
50NME21.08328519
51MAPK111.07779077
52MAP3K111.07183893
53PRKD21.06467320
54SIK31.04290118
55ERBB41.03536350
56TXK1.03294539
57ZAP701.03215636
58CDK61.03012973
59JAK11.01017074
60MAP3K81.00958387
61IRAK20.98666733
62JAK20.96982193
63MAP3K60.95733809
64LCK0.94846043
65MET0.91119975
66PTK20.90832793
67IRAK10.90511811
68BMX0.90151680
69PDK10.88304502
70PDGFRA0.86448682
71TESK10.85302719
72CDC42BPA0.83938674
73CDK40.83136795
74CSF1R0.82474397
75IKBKE0.78829576
76MAP3K20.78123531
77PIK3CG0.77334565
78MARK30.76557430
79IRAK40.76495554
80SIK20.73962654
81BTK0.70675173
82NEK20.69612912
83CDK120.68416223
84KIT0.68355133
85PIM20.68200677
86STK30.65242583
87MAP2K20.64112189
88PIM10.62249847
89BMPR20.62198304
90FRK0.61685226
91MAP3K70.61463296
92IKBKB0.61092087
93FYN0.61072228
94ICK0.60954545
95PDK40.60009841
96PDK30.60009841
97MTOR0.60009349
98MAPK120.59622262
99PRKAA20.57064296
100HIPK20.57059942
101RPS6KL10.55500334
102RPS6KC10.55500334
103DYRK1B0.55303657
104HCK0.55236684
105FGR0.54872138
106FGFR30.54184207
107GSK3A0.54177547
108RET0.54043603
109MAP2K40.53379526
110PAK20.53288746
111SCYL20.52940327
112NEK10.52937542
113MAP2K10.52899631
114MAPKAPK30.51106047
115RAF10.50207391
116TAOK20.50089907
117SGK30.50038639
118MAPK40.48845419
119TAOK10.48442918
120TGFBR10.47041259
121PDPK10.46775150
122KSR20.46704963
123TEC0.46535917
124CHUK0.45489813
125EGFR0.44624090
126CDK190.44314660
127ITK0.44295365
128EIF2AK10.43698162
129MAPK70.43669289
130STK380.43281980
131PRKG20.42453829
132RPS6KA60.42274942
133KSR10.41741844
134STK110.41061408
135EPHA30.41054734
136FGFR10.40394392
137MAPKAPK20.40179883
138ABL10.39901722
139MAP3K50.39148979
140PDK20.39082906
141RPS6KB20.38519279
142MATK0.38394810
143CAMK1G0.38233429
144PTK2B0.37640894
145ACVR1B0.37544107
146MAP2K60.37032416
147CAMKK10.36631234
148RPS6KA20.36464718
149MOS0.36112096
150BUB10.35699253

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.58635291
2Nitrogen metabolism_Homo sapiens_hsa009103.38319552
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.10185644
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.62525012
5Fatty acid degradation_Homo sapiens_hsa000712.59099792
6Arginine biosynthesis_Homo sapiens_hsa002202.58658336
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.58287098
8Complement and coagulation cascades_Homo sapiens_hsa046102.45254653
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.40297008
10B cell receptor signaling pathway_Homo sapiens_hsa046622.39009568
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.31248608
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.31053376
13Staphylococcus aureus infection_Homo sapiens_hsa051502.29985474
14Tryptophan metabolism_Homo sapiens_hsa003802.29692430
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.19934398
16Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.18771117
17PPAR signaling pathway_Homo sapiens_hsa033202.12596663
18Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.09861319
19Caffeine metabolism_Homo sapiens_hsa002322.02818827
20Propanoate metabolism_Homo sapiens_hsa006402.01203289
21Fatty acid metabolism_Homo sapiens_hsa012122.01141580
22Allograft rejection_Homo sapiens_hsa053301.99172247
23Graft-versus-host disease_Homo sapiens_hsa053321.97635986
24Acute myeloid leukemia_Homo sapiens_hsa052211.93990588
25Peroxisome_Homo sapiens_hsa041461.89432918
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.84901764
27Autoimmune thyroid disease_Homo sapiens_hsa053201.83919401
28Measles_Homo sapiens_hsa051621.74515583
29Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.72090408
30Histidine metabolism_Homo sapiens_hsa003401.71847437
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.69315741
32beta-Alanine metabolism_Homo sapiens_hsa004101.66883941
33NOD-like receptor signaling pathway_Homo sapiens_hsa046211.65774324
34Butanoate metabolism_Homo sapiens_hsa006501.65075126
35Drug metabolism - other enzymes_Homo sapiens_hsa009831.64871224
36Primary immunodeficiency_Homo sapiens_hsa053401.62986262
37Chemokine signaling pathway_Homo sapiens_hsa040621.62899453
38Chemical carcinogenesis_Homo sapiens_hsa052041.59712290
39Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.59520734
40Influenza A_Homo sapiens_hsa051641.58269924
41Selenocompound metabolism_Homo sapiens_hsa004501.56167456
42Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.52349549
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.45444700
44T cell receptor signaling pathway_Homo sapiens_hsa046601.45145437
45Carbon metabolism_Homo sapiens_hsa012001.44995616
46Antigen processing and presentation_Homo sapiens_hsa046121.44310106
47Non-small cell lung cancer_Homo sapiens_hsa052231.43059442
48Viral myocarditis_Homo sapiens_hsa054161.41535605
49Biosynthesis of amino acids_Homo sapiens_hsa012301.40644706
50Pyruvate metabolism_Homo sapiens_hsa006201.40418524
51Folate biosynthesis_Homo sapiens_hsa007901.39980281
52Phagosome_Homo sapiens_hsa041451.39768809
53Fat digestion and absorption_Homo sapiens_hsa049751.38775117
54Steroid hormone biosynthesis_Homo sapiens_hsa001401.38757735
55Hematopoietic cell lineage_Homo sapiens_hsa046401.37519855
56Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.36291183
57Herpes simplex infection_Homo sapiens_hsa051681.33528758
58Type I diabetes mellitus_Homo sapiens_hsa049401.32510235
59Chronic myeloid leukemia_Homo sapiens_hsa052201.31668517
60Retinol metabolism_Homo sapiens_hsa008301.31344105
61Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.25122792
62Jak-STAT signaling pathway_Homo sapiens_hsa046301.24722198
63African trypanosomiasis_Homo sapiens_hsa051431.24199186
64Phenylalanine metabolism_Homo sapiens_hsa003601.23878846
65Pancreatic cancer_Homo sapiens_hsa052121.23453470
66Hepatitis B_Homo sapiens_hsa051611.23253386
67Cysteine and methionine metabolism_Homo sapiens_hsa002701.21215665
68Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.20151425
69Starch and sucrose metabolism_Homo sapiens_hsa005001.18333170
70Sulfur relay system_Homo sapiens_hsa041221.17741954
71Bile secretion_Homo sapiens_hsa049761.17549199
72Pentose phosphate pathway_Homo sapiens_hsa000301.16116943
73Sulfur metabolism_Homo sapiens_hsa009201.12480115
74VEGF signaling pathway_Homo sapiens_hsa043701.12389708
75Cyanoamino acid metabolism_Homo sapiens_hsa004601.05552982
76Fatty acid biosynthesis_Homo sapiens_hsa000611.04551710
77Vitamin B6 metabolism_Homo sapiens_hsa007501.04031562
78Platelet activation_Homo sapiens_hsa046111.03921515
79One carbon pool by folate_Homo sapiens_hsa006701.03893020
80Salmonella infection_Homo sapiens_hsa051321.03419032
81Vitamin digestion and absorption_Homo sapiens_hsa049771.03224736
82Shigellosis_Homo sapiens_hsa051311.02716616
83Notch signaling pathway_Homo sapiens_hsa043301.01088371
84Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.00302344
85Glutathione metabolism_Homo sapiens_hsa004801.00049490
86Fatty acid elongation_Homo sapiens_hsa000620.98644080
87Tyrosine metabolism_Homo sapiens_hsa003500.97068532
88ABC transporters_Homo sapiens_hsa020100.95298823
89Renal cell carcinoma_Homo sapiens_hsa052110.95078180
90Glycerolipid metabolism_Homo sapiens_hsa005610.95062209
91Intestinal immune network for IgA production_Homo sapiens_hsa046720.94867325
92Steroid biosynthesis_Homo sapiens_hsa001000.94407752
93AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.92837544
94Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.92376133
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.91885321
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.91678370
97Prolactin signaling pathway_Homo sapiens_hsa049170.90542421
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.89896052
99Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.89574805
100Arginine and proline metabolism_Homo sapiens_hsa003300.87883698
101Asthma_Homo sapiens_hsa053100.86607413
102Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85446869
103Endocytosis_Homo sapiens_hsa041440.83122578
104Endometrial cancer_Homo sapiens_hsa052130.79114283
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.75911215
106Sphingolipid signaling pathway_Homo sapiens_hsa040710.75656387
107Lysine degradation_Homo sapiens_hsa003100.74701069
108Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74413711
109Rheumatoid arthritis_Homo sapiens_hsa053230.71562317
110Viral carcinogenesis_Homo sapiens_hsa052030.70579706
111Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70145775
112Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.67956112
113Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.66635687
114FoxO signaling pathway_Homo sapiens_hsa040680.65989487
115GnRH signaling pathway_Homo sapiens_hsa049120.64756769
116Choline metabolism in cancer_Homo sapiens_hsa052310.64716988
117Epstein-Barr virus infection_Homo sapiens_hsa051690.63539671
118mTOR signaling pathway_Homo sapiens_hsa041500.63219601
119Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62367043
120Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62191546
121Adipocytokine signaling pathway_Homo sapiens_hsa049200.60855890
122Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60737096
123HTLV-I infection_Homo sapiens_hsa051660.60219281
124HIF-1 signaling pathway_Homo sapiens_hsa040660.59922055
125Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57894146
126Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56371760
127Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.55581584
128Colorectal cancer_Homo sapiens_hsa052100.54267241
129Legionellosis_Homo sapiens_hsa051340.53081257
130ErbB signaling pathway_Homo sapiens_hsa040120.51287523
131Insulin signaling pathway_Homo sapiens_hsa049100.51091773
132Inositol phosphate metabolism_Homo sapiens_hsa005620.51011403
133Prostate cancer_Homo sapiens_hsa052150.49912785
134Fructose and mannose metabolism_Homo sapiens_hsa000510.49330111
135Leishmaniasis_Homo sapiens_hsa051400.48928595
136* Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48400377
137Insulin resistance_Homo sapiens_hsa049310.47359076
138Galactose metabolism_Homo sapiens_hsa000520.46596515
139Type II diabetes mellitus_Homo sapiens_hsa049300.45537403
140Glioma_Homo sapiens_hsa052140.44409058
141Rap1 signaling pathway_Homo sapiens_hsa040150.44214263
142Thyroid cancer_Homo sapiens_hsa052160.42886605
143Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42643123
144Dorso-ventral axis formation_Homo sapiens_hsa043200.41008507
145Estrogen signaling pathway_Homo sapiens_hsa049150.39799927
146Glycosaminoglycan degradation_Homo sapiens_hsa005310.35891228
147Lysosome_Homo sapiens_hsa041420.35830129
148Maturity onset diabetes of the young_Homo sapiens_hsa049500.32962793
149* Metabolic pathways_Homo sapiens_hsa011000.32502554
150Pertussis_Homo sapiens_hsa051330.31126332
151Prion diseases_Homo sapiens_hsa050200.28849892
152Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.25876498
153Other glycan degradation_Homo sapiens_hsa005110.24037105
154Malaria_Homo sapiens_hsa051440.23454586
155Bladder cancer_Homo sapiens_hsa052190.23138923
156Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.21915396
157AMPK signaling pathway_Homo sapiens_hsa041520.20403527
158Renin-angiotensin system_Homo sapiens_hsa046140.19375100
159Toll-like receptor signaling pathway_Homo sapiens_hsa046200.18164886
160NF-kappa B signaling pathway_Homo sapiens_hsa040640.15394504
161Amoebiasis_Homo sapiens_hsa051460.15384443
162Hepatitis C_Homo sapiens_hsa051600.14635445
163Osteoclast differentiation_Homo sapiens_hsa043800.12615432
164Glycerophospholipid metabolism_Homo sapiens_hsa005640.12488931
165Toxoplasmosis_Homo sapiens_hsa051450.12487955
166Leukocyte transendothelial migration_Homo sapiens_hsa046700.12193244
167alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.10995241
168Central carbon metabolism in cancer_Homo sapiens_hsa052300.10882446
169Apoptosis_Homo sapiens_hsa042100.09314508
170Small cell lung cancer_Homo sapiens_hsa052220.09060808
171Tuberculosis_Homo sapiens_hsa051520.08934619
172RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.08541071
173Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.07800567
174TNF signaling pathway_Homo sapiens_hsa046680.07682782

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