NADK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a mitochondrial kinase that catalyzes the phosphorylation of NAD to yield NADP. Mutations in this gene result in 2,4-dienoyl-CoA reductase deficiency. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.36772462
2L-phenylalanine catabolic process (GO:0006559)7.36772462
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.03906147
4L-phenylalanine metabolic process (GO:0006558)7.03906147
5aromatic amino acid family catabolic process (GO:0009074)6.58651907
6exogenous drug catabolic process (GO:0042738)6.51552346
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.10285141
8glyoxylate metabolic process (GO:0046487)5.98622192
9tryptophan catabolic process (GO:0006569)5.90822491
10indole-containing compound catabolic process (GO:0042436)5.90822491
11indolalkylamine catabolic process (GO:0046218)5.90822491
12kynurenine metabolic process (GO:0070189)5.89170517
13bile acid biosynthetic process (GO:0006699)5.88439676
14cysteine metabolic process (GO:0006534)5.81025276
15alpha-linolenic acid metabolic process (GO:0036109)5.70158206
16omega-hydroxylase P450 pathway (GO:0097267)5.59239917
17tryptophan metabolic process (GO:0006568)5.51409847
18urea cycle (GO:0000050)5.47010118
19urea metabolic process (GO:0019627)5.47010118
20epoxygenase P450 pathway (GO:0019373)5.42978250
21lysine metabolic process (GO:0006553)5.34520449
22lysine catabolic process (GO:0006554)5.34520449
23sulfur amino acid catabolic process (GO:0000098)5.31861185
24high-density lipoprotein particle remodeling (GO:0034375)5.21712643
25serine family amino acid catabolic process (GO:0009071)5.21501639
26negative regulation of fibrinolysis (GO:0051918)5.16672162
27nitrogen cycle metabolic process (GO:0071941)5.07788077
28regulation of fibrinolysis (GO:0051917)5.04083206
29regulation of protein activation cascade (GO:2000257)5.03992373
30fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.01842844
31homocysteine metabolic process (GO:0050667)4.94973081
32bile acid metabolic process (GO:0008206)4.93039132
33complement activation, alternative pathway (GO:0006957)4.88970011
34amino-acid betaine metabolic process (GO:0006577)4.88286647
35peptidyl-glutamic acid carboxylation (GO:0017187)4.87754646
36protein carboxylation (GO:0018214)4.87754646
37oxidative demethylation (GO:0070989)4.80938936
38alpha-amino acid catabolic process (GO:1901606)4.80507549
39regulation of triglyceride catabolic process (GO:0010896)4.79746423
40glycine metabolic process (GO:0006544)4.75512379
41aromatic amino acid family metabolic process (GO:0009072)4.70822895
42regulation of complement activation (GO:0030449)4.70469895
43reverse cholesterol transport (GO:0043691)4.63670885
44regulation of cholesterol esterification (GO:0010872)4.62614155
45serine family amino acid metabolic process (GO:0009069)4.60923431
46plasma lipoprotein particle remodeling (GO:0034369)4.58097501
47protein-lipid complex remodeling (GO:0034368)4.58097501
48macromolecular complex remodeling (GO:0034367)4.58097501
49serine family amino acid biosynthetic process (GO:0009070)4.51825438
50cellular ketone body metabolic process (GO:0046950)4.49578480
51glutamate metabolic process (GO:0006536)4.47678638
52cellular amino acid catabolic process (GO:0009063)4.46740541
53tyrosine metabolic process (GO:0006570)4.41507869
54ethanol oxidation (GO:0006069)4.34899363
55imidazole-containing compound metabolic process (GO:0052803)4.34610865
56triglyceride homeostasis (GO:0070328)4.33981348
57acylglycerol homeostasis (GO:0055090)4.33981348
58negative regulation of cholesterol transport (GO:0032375)4.33596556
59negative regulation of sterol transport (GO:0032372)4.33596556
60cellular glucuronidation (GO:0052695)4.32561149
61S-adenosylmethionine metabolic process (GO:0046500)4.27629119
62coenzyme catabolic process (GO:0009109)4.26393564
63phospholipid efflux (GO:0033700)4.24463415
64aspartate family amino acid catabolic process (GO:0009068)4.22926996
65dicarboxylic acid biosynthetic process (GO:0043650)4.20857026
66cellular modified amino acid catabolic process (GO:0042219)4.16834065
67plasma lipoprotein particle assembly (GO:0034377)4.16626649
68amine catabolic process (GO:0009310)4.15498897
69cellular biogenic amine catabolic process (GO:0042402)4.15498897
70drug metabolic process (GO:0017144)4.12107713
71bile acid and bile salt transport (GO:0015721)4.11166342
72indolalkylamine metabolic process (GO:0006586)4.10874479
73low-density lipoprotein particle remodeling (GO:0034374)4.07711016
74very-low-density lipoprotein particle assembly (GO:0034379)4.06645973
75plasma lipoprotein particle clearance (GO:0034381)4.04624238
76short-chain fatty acid metabolic process (GO:0046459)3.99536834
77arginine metabolic process (GO:0006525)3.98061326
78benzene-containing compound metabolic process (GO:0042537)3.97824156
79cholesterol efflux (GO:0033344)3.95608303
80carboxylic acid catabolic process (GO:0046395)3.92230390
81organic acid catabolic process (GO:0016054)3.92230390
82drug catabolic process (GO:0042737)3.89483074
83ketone body metabolic process (GO:1902224)3.87379554
84heme transport (GO:0015886)3.86611406
85acetyl-CoA metabolic process (GO:0006084)3.84211598
86blood coagulation, intrinsic pathway (GO:0007597)3.82911407
87cofactor catabolic process (GO:0051187)3.82487690
88carnitine metabolic process (GO:0009437)3.77242038
89uronic acid metabolic process (GO:0006063)3.76602905
90glucuronate metabolic process (GO:0019585)3.76602905
91aldehyde catabolic process (GO:0046185)3.70953799
922-oxoglutarate metabolic process (GO:0006103)3.69191711
93fatty acid oxidation (GO:0019395)3.68689713
94protein-lipid complex assembly (GO:0065005)3.68585036
95response to nitrosative stress (GO:0051409)3.67805630
96fatty acid beta-oxidation (GO:0006635)3.67801816
97flavonoid metabolic process (GO:0009812)3.66181275
98L-serine metabolic process (GO:0006563)3.65081551
99regulation of bile acid biosynthetic process (GO:0070857)3.64655703
100monocarboxylic acid catabolic process (GO:0072329)3.63976521
101plasma lipoprotein particle organization (GO:0071827)3.63917027
102lipid oxidation (GO:0034440)3.62589491
103negative regulation of lipase activity (GO:0060192)3.60960981
104fibrinolysis (GO:0042730)3.60060847
105cholesterol homeostasis (GO:0042632)3.58707190
106positive regulation of lipid catabolic process (GO:0050996)3.58674551
107urate metabolic process (GO:0046415)3.58412662
108ethanol metabolic process (GO:0006067)3.55578760
109pyrimidine nucleobase catabolic process (GO:0006208)3.51728239
110negative regulation of protein activation cascade (GO:2000258)3.34861833
111nucleobase catabolic process (GO:0046113)3.22010806
112regulation of plasminogen activation (GO:0010755)3.14970398
113intestinal cholesterol absorption (GO:0030299)3.13945468
114phenylpropanoid metabolic process (GO:0009698)3.13825443
115alkaloid metabolic process (GO:0009820)3.05543974
116embryonic retina morphogenesis in camera-type eye (GO:0060059)2.90720105
117protein activation cascade (GO:0072376)2.89023013
118L-methionine salvage (GO:0071267)2.88056448
119L-methionine biosynthetic process (GO:0071265)2.88056448
120amino acid salvage (GO:0043102)2.88056448
121opsonization (GO:0008228)2.74220170
122positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.71839397
123midgut development (GO:0007494)2.68780079
124negative regulation of complement activation (GO:0045916)2.67548669
125polyketide metabolic process (GO:0030638)2.66334476
126doxorubicin metabolic process (GO:0044598)2.66334476
127daunorubicin metabolic process (GO:0044597)2.66334476
128negative regulation of hemostasis (GO:1900047)2.65371629
129negative regulation of blood coagulation (GO:0030195)2.65371629
130phospholipid homeostasis (GO:0055091)2.65190223
131xenobiotic catabolic process (GO:0042178)2.63654456
132response to mercury ion (GO:0046689)2.62791197
133C4-dicarboxylate transport (GO:0015740)2.61942135
134methionine metabolic process (GO:0006555)2.58587110

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.24772637
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.11947364
3EGR1_23403033_ChIP-Seq_LIVER_Mouse7.11873322
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.36278739
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.00881776
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.99620249
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.85420242
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.16360810
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.75773363
10GBX2_23144817_ChIP-Seq_PC3_Human3.21132488
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.87462552
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.83043822
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.81978168
14IGF1R_20145208_ChIP-Seq_DFB_Human2.65209544
15FUS_26573619_Chip-Seq_HEK293_Human2.38786016
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.37769717
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.24717205
18TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.23130359
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.22712799
20GATA1_22025678_ChIP-Seq_K562_Human2.22658663
21HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.18153190
22PIAS1_25552417_ChIP-Seq_VCAP_Human2.11080138
23TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.05126369
24ESR1_17901129_ChIP-ChIP_LIVER_Mouse12.0601883
25AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.96825827
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.87712745
27SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.87501602
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.87053841
29EWS_26573619_Chip-Seq_HEK293_Human1.83851852
30VDR_22108803_ChIP-Seq_LS180_Human1.82339369
31P300_19829295_ChIP-Seq_ESCs_Human1.81566143
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.76835207
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72886411
34EZH2_22144423_ChIP-Seq_EOC_Human1.61753400
35CLOCK_20551151_ChIP-Seq_293T_Human1.61521994
36MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.57022334
37FOXA2_19822575_ChIP-Seq_HepG2_Human1.56282452
38HTT_18923047_ChIP-ChIP_STHdh_Human1.55869694
39OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55724148
40SMAD4_21799915_ChIP-Seq_A2780_Human1.55583338
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.55577839
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.55101393
43ER_23166858_ChIP-Seq_MCF-7_Human1.53309337
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52480787
45STAT3_23295773_ChIP-Seq_U87_Human1.47611582
46UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44803553
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43751606
48HNF4A_19822575_ChIP-Seq_HepG2_Human1.42841102
49PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.40934413
50CDX2_19796622_ChIP-Seq_MESCs_Mouse1.39812108
51ZNF274_21170338_ChIP-Seq_K562_Hela1.38394917
52ZNF263_19887448_ChIP-Seq_K562_Human1.38259663
53RNF2_27304074_Chip-Seq_NSC_Mouse1.37044720
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.35243923
55TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.35096354
56FLI1_27457419_Chip-Seq_LIVER_Mouse1.34211814
57IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33390751
58CBP_20019798_ChIP-Seq_JUKART_Human1.33390751
59NANOG_18555785_Chip-Seq_ESCs_Mouse1.33184543
60TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.31532134
61AR_25329375_ChIP-Seq_VCAP_Human1.29627194
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29004243
63EZH2_27294783_Chip-Seq_NPCs_Mouse1.26914147
64ESR1_15608294_ChIP-ChIP_MCF-7_Human1.26830119
65TCF4_23295773_ChIP-Seq_U87_Human1.26364598
66EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.24054640
67BCAT_22108803_ChIP-Seq_LS180_Human1.22228328
68NR3C1_21868756_ChIP-Seq_MCF10A_Human1.22184417
69SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20961164
70KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.20158919
71ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.19808832
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19710913
73KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18393716
74RXRA_24833708_ChIP-Seq_LIVER_Mouse1.17215112
75NFE2_27457419_Chip-Seq_LIVER_Mouse1.17155873
76RUNX2_22187159_ChIP-Seq_PCA_Human1.16928862
77P53_22387025_ChIP-Seq_ESCs_Mouse1.16113056
78MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15337229
79PCGF2_27294783_Chip-Seq_ESCs_Mouse1.13571017
80E2F1_18555785_Chip-Seq_ESCs_Mouse1.10225886
81TCF4_22108803_ChIP-Seq_LS180_Human1.10091772
82TP53_18474530_ChIP-ChIP_U2OS_Human1.09455264
83CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.07580605
84TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06735833
85E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.05862267
86FOXM1_26456572_ChIP-Seq_MCF-7_Human1.05284075
87EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.05004819
88EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.03969104
89SUZ12_18555785_Chip-Seq_ESCs_Mouse1.03959342
90RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.03534642
91SCL_19346495_ChIP-Seq_HPC-7_Human1.03369086
92ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03242590
93AR_21572438_ChIP-Seq_LNCaP_Human1.02971319
94KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.02633735
95SOX2_21211035_ChIP-Seq_LN229_Gbm1.02621320
96AR_21909140_ChIP-Seq_LNCAP_Human1.02490326
97GATA1_19941826_ChIP-Seq_K562_Human1.02166006
98SOX9_26525672_Chip-Seq_HEART_Mouse1.00739074
99TAL1_26923725_Chip-Seq_HPCs_Mouse1.00687537
100CMYC_18555785_Chip-Seq_ESCs_Mouse0.99985887
101CRX_20693478_ChIP-Seq_RETINA_Mouse0.99612318
102STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.99039604
103SOX2_19829295_ChIP-Seq_ESCs_Human0.98997807
104NANOG_19829295_ChIP-Seq_ESCs_Human0.98997807
105PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98480868
106JUN_21703547_ChIP-Seq_K562_Human0.97901357
107AUTS2_25519132_ChIP-Seq_293T-REX_Human0.96764077
108P300_18555785_Chip-Seq_ESCs_Mouse0.96352165
109TBX3_20139965_ChIP-Seq_MESCs_Mouse0.96185625
110TBX3_20139965_ChIP-Seq_ESCs_Mouse0.95916187
111SALL4_18804426_ChIP-ChIP_XEN_Mouse0.95559811
112LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95460402
113SOX2_27498859_Chip-Seq_STOMACH_Mouse0.95406599
114GATA1_19941827_ChIP-Seq_MEL_Mouse0.95225636
115STAT3_1855785_ChIP-Seq_MESCs_Mouse0.92715415
116THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.91503856
117SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.84399232
118NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.83709122
119TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.81627446
120SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.78711381
121ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.75821560
122GATA4_25053715_ChIP-Seq_YYC3_Human0.75640963
123AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.72422421
124GATA2_19941826_ChIP-Seq_K562_Human0.71970571
125BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.69934968
126RARA_24833708_ChIP-Seq_LIVER_Mouse0.68481599
127FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.68430026
128KAP1_22055183_ChIP-Seq_ESCs_Mouse0.66823783
129PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.65876446
130FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.63269997
131RBPJ_22232070_ChIP-Seq_NCS_Mouse0.63093159
132AR_20517297_ChIP-Seq_VCAP_Human0.62810922
133GATA1_22383799_ChIP-Seq_G1ME_Mouse0.60854861
134FOXA1_25552417_ChIP-Seq_VCAP_Human0.60356970
135PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.60112776
136HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.60028469
137TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.58382070
138STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.58061226
139IRF1_19129219_ChIP-ChIP_H3396_Human0.57569037
140ERG_20517297_ChIP-Seq_VCAP_Human0.56974389
141RARB_24833708_ChIP-Seq_LIVER_Mouse0.55691661
142PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.55659049
143CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.53789097
144ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.53167154
145CEBPB_22108803_ChIP-Seq_LS180_Human0.52649607
146POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.52137221
147CBP_21632823_ChIP-Seq_H3396_Human0.52079982
148FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.50448508
149ESET_19884257_ChIP-Seq_ESCs_Mouse0.47223433
150FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.45828273
151BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.45181369
152GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.45158237
153PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.44405197
154STAT1_17558387_ChIP-Seq_HELA_Human0.43863113
155RAD21_21589869_ChIP-Seq_MESCs_Mouse0.43015096
156KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.42648379
157PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.41309008
158CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.40542474
159GATA6_25053715_ChIP-Seq_YYC3_Human0.40278981
160SRF_21415370_ChIP-Seq_HL-1_Mouse0.39906929
161TAF2_19829295_ChIP-Seq_ESCs_Human0.39681999
162RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.39655368
163TCF3_18692474_ChIP-Seq_MEFs_Mouse0.39261860
164SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.38422473
165SOX2_18692474_ChIP-Seq_MEFs_Mouse0.38228348
166ESR1_20079471_ChIP-ChIP_T-47D_Human0.38144353
167NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.37299676
168MYC_19915707_ChIP-ChIP_AK7_Human0.36971398
169CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.36815018
170GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.36794850
171GATA2_22383799_ChIP-Seq_G1ME_Mouse0.36753864
172BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.36636145
173NRF2_20460467_ChIP-Seq_MEFs_Mouse0.35490967
174NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.35490967
175IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.35393972
176NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.35376043
177POU5F1_16518401_ChIP-PET_MESCs_Mouse0.33872715
178TAF15_26573619_Chip-Seq_HEK293_Human0.32469318
179P53_21459846_ChIP-Seq_SAOS-2_Human0.32336383
180CDX2_22108803_ChIP-Seq_LS180_Human0.32282234
181MYC_27129775_Chip-Seq_CORNEA_Mouse0.32034608

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.14889558
2MP0005360_urolithiasis7.35597809
3MP0005085_abnormal_gallbladder_physiolo6.45157200
4MP0005365_abnormal_bile_salt6.06338823
5MP0008875_abnormal_xenobiotic_pharmacok5.04095680
6MP0003806_abnormal_nucleotide_metabolis4.79724007
7MP0003252_abnormal_bile_duct3.76337296
8MP0010329_abnormal_lipoprotein_level3.43383403
9MP0005083_abnormal_biliary_tract3.11201969
10MP0009840_abnormal_foam_cell2.87528107
11MP0005332_abnormal_amino_acid2.79964266
12MP0003195_calcinosis2.73206242
13MP0001666_abnormal_nutrient_absorption2.57796050
14MP0003656_abnormal_erythrocyte_physiolo2.28253729
15MP0003011_delayed_dark_adaptation2.20262651
16MP0004019_abnormal_vitamin_homeostasis2.07974038
17MP0000609_abnormal_liver_physiology2.03477435
18MP0002118_abnormal_lipid_homeostasis2.00572552
19MP0001764_abnormal_homeostasis1.90481446
20MP0003191_abnormal_cellular_cholesterol1.90464201
21MP0005319_abnormal_enzyme/_coenzyme1.84588066
22MP0004147_increased_porphyrin_level1.84223050
23MP0003868_abnormal_feces_composition1.77104551
24MP0005187_abnormal_penis_morphology1.76638885
25MP0009697_abnormal_copulation1.71048681
26MP0002138_abnormal_hepatobiliary_system1.64643684
27MP0003136_yellow_coat_color1.64610771
28MP0002638_abnormal_pupillary_reflex1.63471946
29MP0005584_abnormal_enzyme/coenzyme_acti1.63322641
30MP0003186_abnormal_redox_activity1.55003675
31MP0002102_abnormal_ear_morphology1.41435659
32MP0002234_abnormal_pharynx_morphology1.38946744
33MP0006036_abnormal_mitochondrial_physio1.32647907
34MP0000778_abnormal_nervous_system1.29991541
35MP0009643_abnormal_urine_homeostasis1.23991505
36MP0005451_abnormal_body_composition1.23449973
37MP0001984_abnormal_olfaction1.19885948
38MP0000598_abnormal_liver_morphology1.19414959
39MP0003122_maternal_imprinting1.17795168
40MP0005647_abnormal_sex_gland1.15405779
41MP0003880_abnormal_central_pattern1.14932370
42MP0004885_abnormal_endolymph1.14429093
43MP0001486_abnormal_startle_reflex1.12203949
44MP0004142_abnormal_muscle_tone1.10643543
45MP0005636_abnormal_mineral_homeostasis1.09867652
46MP0002735_abnormal_chemical_nociception1.05993093
47MP0002282_abnormal_trachea_morphology1.04616920
48MP0002909_abnormal_adrenal_gland1.01585246
49MP0009780_abnormal_chondrocyte_physiolo0.99735224
50MP0009763_increased_sensitivity_to0.98898802
51MP0002938_white_spotting0.96764991
52MP0002697_abnormal_eye_size0.93980801
53MP0003890_abnormal_embryonic-extraembry0.93746268
54MP0006035_abnormal_mitochondrial_morpho0.93483395
55MP0009053_abnormal_anal_canal0.93153389
56MP0002822_catalepsy0.92945583
57MP0009764_decreased_sensitivity_to0.92718569
58MP0002233_abnormal_nose_morphology0.91855879
59MP0009745_abnormal_behavioral_response0.91790085
60MP0010368_abnormal_lymphatic_system0.91503553
61MP0003690_abnormal_glial_cell0.91449675
62MP0002272_abnormal_nervous_system0.90866011
63MP0006292_abnormal_olfactory_placode0.89923709
64MP0001485_abnormal_pinna_reflex0.89493433
65MP0002736_abnormal_nociception_after0.88804522
66MP0005376_homeostasis/metabolism_phenot0.88434981
67MP0003937_abnormal_limbs/digits/tail_de0.87865230
68MP0002557_abnormal_social/conspecific_i0.87292740
69MP0000955_abnormal_spinal_cord0.87132401
70MP0005266_abnormal_metabolism0.84505204
71MP0003121_genomic_imprinting0.83414406
72MP0009765_abnormal_xenobiotic_induced0.82803533
73MP0002063_abnormal_learning/memory/cond0.82695528
74MP0003705_abnormal_hypodermis_morpholog0.81800291
75MP0005408_hypopigmentation0.81190629
76MP0004924_abnormal_behavior0.80966069
77MP0005386_behavior/neurological_phenoty0.80966069
78MP0004859_abnormal_synaptic_plasticity0.80403516
79MP0000631_abnormal_neuroendocrine_gland0.80277957
80MP0004130_abnormal_muscle_cell0.79503369
81MP0009642_abnormal_blood_homeostasis0.78877749
82MP0000516_abnormal_urinary_system0.77684198
83MP0005367_renal/urinary_system_phenotyp0.77684198
84MP0001293_anophthalmia0.77670529
85MP0002064_seizures0.76191276
86MP0004215_abnormal_myocardial_fiber0.76013842
87MP0005670_abnormal_white_adipose0.74675681
88MP0001529_abnormal_vocalization0.74107489
89MP0002572_abnormal_emotion/affect_behav0.73163435
90MP0005551_abnormal_eye_electrophysiolog0.72834361
91MP0001968_abnormal_touch/_nociception0.72808569
92MP0001286_abnormal_eye_development0.72556734
93MP0002971_abnormal_brown_adipose0.71941476
94MP0003635_abnormal_synaptic_transmissio0.71576695
95MP0000569_abnormal_digit_pigmentation0.71118718
96MP0000604_amyloidosis0.71112569
97MP0005423_abnormal_somatic_nervous0.70929397
98MP0001502_abnormal_circadian_rhythm0.70506977
99MP0000013_abnormal_adipose_tissue0.69873283
100MP0002078_abnormal_glucose_homeostasis0.68556528
101MP0002009_preneoplasia0.68453963
102MP0004043_abnormal_pH_regulation0.68396877
103MP0005084_abnormal_gallbladder_morpholo0.67844691
104MP0004270_analgesia0.66638998
105MP0006072_abnormal_retinal_apoptosis0.66203183
106MP0005171_absent_coat_pigmentation0.65930732
107MP0008469_abnormal_protein_level0.65915990
108MP0003633_abnormal_nervous_system0.64885748
109MP0008877_abnormal_DNA_methylation0.63024971
110MP0002067_abnormal_sensory_capabilities0.62478306
111MP0003119_abnormal_digestive_system0.62468549
112MP0003632_abnormal_nervous_system0.62290695
113MP0005391_vision/eye_phenotype0.62049945
114MP0002132_abnormal_respiratory_system0.61896763
115MP0005220_abnormal_exocrine_pancreas0.61732937
116MP0002184_abnormal_innervation0.61598878
117MP0005334_abnormal_fat_pad0.60082929
118MP0005535_abnormal_body_temperature0.58997988
119MP0001661_extended_life_span0.58945959
120MP0009384_cardiac_valve_regurgitation0.55259424
121MP0000639_abnormal_adrenal_gland0.54825185
122MP0002254_reproductive_system_inflammat0.50227831
123MP0008872_abnormal_physiological_respon0.50113363
124MP0009672_abnormal_birth_weight0.48077794
125MP0003718_maternal_effect0.47195296
126MP0008873_increased_physiological_sensi0.44955600
127MP0003329_amyloid_beta_deposits0.44658164
128MP0002837_dystrophic_cardiac_calcinosis0.44644947
129MP0005666_abnormal_adipose_tissue0.43914390
130MP0003638_abnormal_response/metabolism_0.42655303
131MP0005248_abnormal_Harderian_gland0.41994745
132MP0005464_abnormal_platelet_physiology0.40680079
133MP0008874_decreased_physiological_sensi0.40567174
134MP0001756_abnormal_urination0.39895855
135MP0004264_abnormal_extraembryonic_tissu0.38283994
136MP0002136_abnormal_kidney_physiology0.37854021
137MP0001324_abnormal_eye_pigmentation0.37793993
138MP0005448_abnormal_energy_balance0.37672710
139MP0005646_abnormal_pituitary_gland0.35468716
140MP0003075_altered_response_to0.35296965
141MP0002269_muscular_atrophy0.33868786
142MP0005395_other_phenotype0.33455288
143MP0002090_abnormal_vision0.32914826
144MP0000566_synostosis0.32741121
145MP0002970_abnormal_white_adipose0.31741468
146MP0003953_abnormal_hormone_level0.31529463
147MP0001915_intracranial_hemorrhage0.30919597
148MP0009115_abnormal_fat_cell0.30822642
149MP0005330_cardiomyopathy0.30213025
150MP0002928_abnormal_bile_duct0.29960356
151MP0000230_abnormal_systemic_arterial0.28244793
152MP0005075_abnormal_melanosome_morpholog0.27789447
153MP0004381_abnormal_hair_follicle0.25612184
154MP0002876_abnormal_thyroid_physiology0.25264607
155MP0002249_abnormal_larynx_morphology0.24081793
156MP0005166_decreased_susceptibility_to0.23194897
157MP0005253_abnormal_eye_physiology0.22949389
158MP0005195_abnormal_posterior_eye0.22716133
159MP0002128_abnormal_blood_circulation0.21573021
160MP0004782_abnormal_surfactant_physiolog0.20382257

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)7.28501726
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.75942650
3Deep venous thrombosis (HP:0002625)6.68840728
4Hypobetalipoproteinemia (HP:0003563)6.35238472
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.17266840
6Prolonged partial thromboplastin time (HP:0003645)5.91725461
7Xanthomatosis (HP:0000991)5.79146898
8Hyperlipoproteinemia (HP:0010980)5.08615846
9Hyperammonemia (HP:0001987)4.80482875
10Hypolipoproteinemia (HP:0010981)4.67061880
11Complement deficiency (HP:0004431)4.65267581
12Hyperglycinemia (HP:0002154)4.51877265
13Ketosis (HP:0001946)4.37022579
14Abnormality of serine family amino acid metabolism (HP:0010894)4.31077772
15Abnormality of glycine metabolism (HP:0010895)4.31077772
16Joint hemorrhage (HP:0005261)4.30420878
17Abnormality of methionine metabolism (HP:0010901)4.28233680
18Hyperglycinuria (HP:0003108)4.27440101
19Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.25565948
20Epidermoid cyst (HP:0200040)4.23833096
21Abnormality of aspartate family amino acid metabolism (HP:0010899)4.22463615
22Abnormality of sulfur amino acid metabolism (HP:0004339)4.20560777
23Hypoglycemic coma (HP:0001325)4.07356020
24Abnormality of the common coagulation pathway (HP:0010990)4.00406514
25Hypochromic microcytic anemia (HP:0004840)3.96844241
26Fat malabsorption (HP:0002630)3.96552255
27Hypoalphalipoproteinemia (HP:0003233)3.90625950
28Abnormality of glutamine family amino acid metabolism (HP:0010902)3.88628195
29Hyperbilirubinemia (HP:0002904)3.85784556
30Acanthocytosis (HP:0001927)3.76764026
31Abnormality of pyrimidine metabolism (HP:0004353)3.62821485
32Poikilocytosis (HP:0004447)3.59393594
33Abnormality of fatty-acid metabolism (HP:0004359)3.50427687
34Hypercholesterolemia (HP:0003124)3.49881686
35Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.38930269
36Abnormality of the intrinsic pathway (HP:0010989)3.35159194
37Ketoacidosis (HP:0001993)3.34878590
38Delayed CNS myelination (HP:0002188)3.31931753
39Abnormality of complement system (HP:0005339)3.23751052
40Abnormality of serum amino acid levels (HP:0003112)3.23270936
41Conjugated hyperbilirubinemia (HP:0002908)3.20949941
42Hepatocellular carcinoma (HP:0001402)3.18889400
43Metabolic acidosis (HP:0001942)3.05678761
44Cholelithiasis (HP:0001081)2.95754548
45Steatorrhea (HP:0002570)2.94756290
46Abnormality of the heme biosynthetic pathway (HP:0010472)2.94703743
47Abnormal gallbladder morphology (HP:0012437)2.91670875
48Abnormality of nucleobase metabolism (HP:0010932)2.90839751
49Spontaneous abortion (HP:0005268)2.84606641
50Abnormality of dicarboxylic acid metabolism (HP:0010995)2.79890157
51Dicarboxylic aciduria (HP:0003215)2.79890157
52Lethargy (HP:0001254)2.75136068
53Abnormal gallbladder physiology (HP:0012438)2.72240603
54Cholecystitis (HP:0001082)2.72240603
55Cerebral edema (HP:0002181)2.72071186
56Spastic diplegia (HP:0001264)2.67512089
57Reticulocytosis (HP:0001923)2.67027731
58Fair hair (HP:0002286)2.60358171
59Hypoglycemic seizures (HP:0002173)2.58129760
60Abnormality of purine metabolism (HP:0004352)2.54848883
61Glomerulonephritis (HP:0000099)2.49001293
62Skin nodule (HP:0200036)2.47820454
63Gout (HP:0001997)2.33827496
64Arthropathy (HP:0003040)2.26260293
65Abnormality of the gallbladder (HP:0005264)2.24418914
66Myocardial infarction (HP:0001658)2.23688837
67Hyperventilation (HP:0002883)2.22479604
68Blue irides (HP:0000635)2.20695571
69Vomiting (HP:0002013)2.20388308
70Pheochromocytoma (HP:0002666)2.20319522
71Enlarged kidneys (HP:0000105)2.20179457
72Osteomalacia (HP:0002749)2.19156719
73Renal cortical cysts (HP:0000803)2.15685501
74Neonatal onset (HP:0003623)2.15517175
75Generalized aminoaciduria (HP:0002909)2.15186394
76Vascular calcification (HP:0004934)2.13767374
77Irritability (HP:0000737)2.13461540
78Gingival bleeding (HP:0000225)2.09741765
79Brushfield spots (HP:0001088)2.09357813
80Confusion (HP:0001289)2.07103489
81Abnormality of glycolysis (HP:0004366)2.06608507
82Mitral stenosis (HP:0001718)2.05878709
83Increased serum pyruvate (HP:0003542)2.05743836
84Abnormality of iron homeostasis (HP:0011031)2.03038065
85Sensorimotor neuropathy (HP:0007141)2.01717017
86Late onset (HP:0003584)2.01084045
87Hyperinsulinemic hypoglycemia (HP:0000825)2.00935561
88Abnormality of transition element cation homeostasis (HP:0011030)2.00327625
89Abnormal biliary tract physiology (HP:0012439)1.97656452
90Bile duct proliferation (HP:0001408)1.97656452
91Thrombophlebitis (HP:0004418)1.97568488
92Abnormality of urine glucose concentration (HP:0011016)1.95183796
93Glycosuria (HP:0003076)1.95183796
94Malnutrition (HP:0004395)1.94829142
95Abnormality of alanine metabolism (HP:0010916)1.93083080
96Hyperalaninemia (HP:0003348)1.93083080
97Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.93083080
98Megalencephaly (HP:0001355)1.91908082
99Chorioretinal atrophy (HP:0000533)1.91585634
100Pigmentary retinal degeneration (HP:0001146)1.90475529
101Rickets (HP:0002748)1.88636795
102Proximal tubulopathy (HP:0000114)1.87696640
103Nausea (HP:0002018)1.86759112
104Abnormality of the renal cortex (HP:0011035)1.86516098
105Pancreatitis (HP:0001733)1.86148584
106Esophageal varix (HP:0002040)1.85967850
107Elevated hepatic transaminases (HP:0002910)1.85311743
108Cardiovascular calcification (HP:0011915)1.84454502
109Abnormality of vitamin metabolism (HP:0100508)1.83945247
110Neuroendocrine neoplasm (HP:0100634)1.82458430
111Papillary thyroid carcinoma (HP:0002895)1.80921303
112Systemic lupus erythematosus (HP:0002725)1.80429961
113Amyloidosis (HP:0011034)1.79825188
114Menorrhagia (HP:0000132)1.78332503
115Morphological abnormality of the pyramidal tract (HP:0002062)1.77567284
116Alkalosis (HP:0001948)1.75913965
117Myoglobinuria (HP:0002913)1.75879049
118Status epilepticus (HP:0002133)1.74589472
119Hepatoblastoma (HP:0002884)1.72953706
120Bifid scrotum (HP:0000048)1.71216898
121Microcytic anemia (HP:0001935)1.70065976
122Abnormal cartilage morphology (HP:0002763)1.70032027
123Degeneration of the lateral corticospinal tracts (HP:0002314)1.68580667
124Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.68580667
125Gonadotropin excess (HP:0000837)1.62478774
126Megaloblastic anemia (HP:0001889)1.62016360
127Generalized hypopigmentation of hair (HP:0011358)1.61015459
128Hypophosphatemic rickets (HP:0004912)1.60247258
129True hermaphroditism (HP:0010459)1.59362647
130Abnormality of the corticospinal tract (HP:0002492)1.59202523
131Action tremor (HP:0002345)1.56387183
132Nephritis (HP:0000123)1.55830435
133Drooling (HP:0002307)1.55234077
134Pancreatic fibrosis (HP:0100732)1.54476873
135Acute encephalopathy (HP:0006846)1.52620977
136Hyperphosphaturia (HP:0003109)1.51476157
137Hypothermia (HP:0002045)1.50256993
138Neoplasm of the liver (HP:0002896)1.48840412
139Aplasia/Hypoplasia of the tibia (HP:0005772)1.47947617
140Pancreatic cysts (HP:0001737)1.47509513
141Methylmalonic acidemia (HP:0002912)1.45054297
142Hemiparesis (HP:0001269)1.44646937
143Hypsarrhythmia (HP:0002521)1.44084977
144Short tibia (HP:0005736)1.43616981

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.29914338
2SIK13.79305486
3PKN23.40688819
4CASK3.35273069
5FGFR43.26584059
6INSRR3.16751423
7PNCK2.83439751
8STK392.67796548
9FLT32.38939968
10TAOK32.30500422
11TNIK2.26232328
12EIF2AK32.25149726
13ERN12.22441640
14MAPK112.13981006
15PINK12.10004076
16ERBB42.09907394
17MAP3K42.00864996
18MARK11.99177752
19MAP2K41.86863018
20TRIB31.76333617
21WNK31.76249428
22NTRK31.75170041
23BMPR1B1.74726613
24ERBB31.74256304
25WNK41.70965580
26PLK21.70295885
27TAOK21.68855789
28LMTK21.59960672
29FGFR21.59888535
30BRSK21.57434009
31MKNK21.52712201
32MAP3K101.52282076
33NEK11.46914637
34MAP2K31.46107825
35MAP2K71.46020066
36BCR1.43849026
37NTRK21.40058029
38FRK1.37824248
39PIK3CG1.37776104
40PDK41.36352349
41PDK31.36352349
42PBK1.31247024
43ERBB21.30000838
44MAPK131.29846784
45NEK91.26737891
46EIF2AK11.25664101
47MAP2K61.24515664
48CSNK1G21.22452295
49TIE11.22308971
50ABL21.19762432
51CAMKK21.19176525
52PRKAA21.16458071
53GRK61.15152589
54CDK61.15027140
55AKT31.13576435
56GRK11.12387046
57MAP3K71.11349811
58MST1R1.11289744
59SGK31.07291439
60EPHA41.06660143
61NUAK11.06307753
62LATS11.06248212
63CAMK1G1.05963531
64TAF11.05582502
65PTK61.01613731
66SGK21.01341535
67MET1.00991134
68JAK21.00580966
69PLK40.98653289
70BRD40.97067801
71SGK4940.95490849
72SGK2230.95490849
73ACVR1B0.95134233
74STK40.94167234
75KDR0.93989967
76PRKD30.93897877
77PLK30.93160850
78PRKCG0.92268292
79MAPK40.91650938
80TSSK60.88872434
81TRIM280.85095902
82PRKACG0.84288259
83MAPK120.83656013
84CDK40.83025799
85PAK30.81996701
86PRKAA10.80730051
87KSR10.79888516
88EPHA30.75797287
89ZAK0.75245037
90CSNK1A1L0.75002016
91PRKCE0.73239068
92TTK0.73059781
93DYRK20.71747353
94DYRK1B0.71719930
95CCNB10.71350537
96PAK60.69487672
97FER0.69352195
98TYK20.68248550
99STK30.66816071
100NTRK10.66138209
101MAP3K20.65783884
102MKNK10.64713508
103MAP3K60.62855324
104OBSCN0.61178207
105EIF2AK20.60611867
106SCYL20.60092380
107CSF1R0.59022830
108MINK10.58131059
109MAPKAPK50.58020915
110CAMK2D0.56946918
111CDC70.55545777
112CAMK2A0.55097867
113WNK10.53301102
114SGK10.52536386
115CAMK2B0.52425500
116PRKCZ0.52415991
117GSK3A0.52384453
118MAP2K10.52095750
119MAP3K50.51971264
120NLK0.51756940
121RAF10.50647978
122AKT20.49884425
123CSNK1G10.48887568
124CAMK2G0.48614940
125CDK120.48541030
126PDK10.47191501
127DYRK1A0.47121130
128ATM0.46974550
129VRK10.46623031
130PIK3CA0.46549809
131ICK0.46501524
132PRKACB0.46138277
133PDPK10.45168673
134YES10.43690287
135MAP3K80.39187472
136STK38L0.38782972
137WEE10.38451480
138TGFBR10.37902673
139RPS6KB10.37199417
140CSNK1D0.36766497
141PDK20.36598194
142DAPK20.36210906
143IRAK20.35972641
144MAPK150.35822304
145RET0.34210773
146TGFBR20.33443085
147CSNK1E0.32716987
148MAPK70.32390375
149EGFR0.32274857
150CAMK1D0.32209008
151CSNK1G30.31768542
152OXSR10.30916248
153IGF1R0.30209968
154PHKG10.29485840
155PHKG20.29485840
156PRKCQ0.29145988
157FGFR30.28920109
158MTOR0.27708392
159CSNK2A20.27575026
160MAPK30.27446842
161TNK20.26163722

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.16013224
2Nitrogen metabolism_Homo sapiens_hsa009104.05213656
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.17170645
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.14662950
5Arginine biosynthesis_Homo sapiens_hsa002202.94654217
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.74078693
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.68445547
8Fatty acid degradation_Homo sapiens_hsa000712.67886042
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.65962377
10Tryptophan metabolism_Homo sapiens_hsa003802.55635275
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.55038294
12Complement and coagulation cascades_Homo sapiens_hsa046102.37203699
13Propanoate metabolism_Homo sapiens_hsa006402.27631241
14Butanoate metabolism_Homo sapiens_hsa006502.24126007
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.21558800
16Peroxisome_Homo sapiens_hsa041462.08196403
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.99179831
18Fatty acid metabolism_Homo sapiens_hsa012121.95414183
19Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.83856236
20Chemical carcinogenesis_Homo sapiens_hsa052041.78603811
21PPAR signaling pathway_Homo sapiens_hsa033201.78209071
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.77699147
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.75552900
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.75539380
25Histidine metabolism_Homo sapiens_hsa003401.74623662
26beta-Alanine metabolism_Homo sapiens_hsa004101.70642606
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.69020370
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.67134000
29Selenocompound metabolism_Homo sapiens_hsa004501.66854481
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.60398840
31Retinol metabolism_Homo sapiens_hsa008301.60361543
32Caffeine metabolism_Homo sapiens_hsa002321.56024409
33Pyruvate metabolism_Homo sapiens_hsa006201.54136730
34Bile secretion_Homo sapiens_hsa049761.50862007
35Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.47472610
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.46048646
37Fatty acid elongation_Homo sapiens_hsa000621.45283913
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.41783211
39Biosynthesis of amino acids_Homo sapiens_hsa012301.39692466
40Sulfur metabolism_Homo sapiens_hsa009201.36634326
41Phenylalanine metabolism_Homo sapiens_hsa003601.36305604
42Carbon metabolism_Homo sapiens_hsa012001.35545150
43Vitamin B6 metabolism_Homo sapiens_hsa007501.31711711
44Tyrosine metabolism_Homo sapiens_hsa003501.28288339
45Starch and sucrose metabolism_Homo sapiens_hsa005001.27339172
46ABC transporters_Homo sapiens_hsa020101.27176943
47Staphylococcus aureus infection_Homo sapiens_hsa051501.24599120
48Folate biosynthesis_Homo sapiens_hsa007901.15108060
49Fat digestion and absorption_Homo sapiens_hsa049751.06180776
50Arginine and proline metabolism_Homo sapiens_hsa003301.04612161
51Steroid biosynthesis_Homo sapiens_hsa001001.01279035
52Cyanoamino acid metabolism_Homo sapiens_hsa004601.00151053
53One carbon pool by folate_Homo sapiens_hsa006701.00037564
54Sulfur relay system_Homo sapiens_hsa041220.99762308
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.98173784
56Lysine degradation_Homo sapiens_hsa003100.92194187
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.91855285
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.89951129
59Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.88795364
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.79904012
61* Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79617462
62Vitamin digestion and absorption_Homo sapiens_hsa049770.77851506
63Glutathione metabolism_Homo sapiens_hsa004800.73997588
64Fatty acid biosynthesis_Homo sapiens_hsa000610.71682884
65Protein export_Homo sapiens_hsa030600.69067258
66Glycerolipid metabolism_Homo sapiens_hsa005610.67201352
67Pentose phosphate pathway_Homo sapiens_hsa000300.65369242
68* Metabolic pathways_Homo sapiens_hsa011000.53264186
69Circadian rhythm_Homo sapiens_hsa047100.50191208
70Nicotine addiction_Homo sapiens_hsa050330.48286257
71Galactose metabolism_Homo sapiens_hsa000520.38849846
72Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.34510780
73Fructose and mannose metabolism_Homo sapiens_hsa000510.34426156
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33697545
75Glutamatergic synapse_Homo sapiens_hsa047240.31655302
76GABAergic synapse_Homo sapiens_hsa047270.29651270
77Linoleic acid metabolism_Homo sapiens_hsa005910.26953590
78Serotonergic synapse_Homo sapiens_hsa047260.26672240
79Fanconi anemia pathway_Homo sapiens_hsa034600.22853346
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.22629671
81Insulin secretion_Homo sapiens_hsa049110.22060201
82Insulin resistance_Homo sapiens_hsa049310.18633504
83Amphetamine addiction_Homo sapiens_hsa050310.18463658
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.17831002
85Cocaine addiction_Homo sapiens_hsa050300.17326984
86Systemic lupus erythematosus_Homo sapiens_hsa053220.16607483
87Circadian entrainment_Homo sapiens_hsa047130.16300317
88Dopaminergic synapse_Homo sapiens_hsa047280.14990230
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.14931203
90Prion diseases_Homo sapiens_hsa050200.13889776
91Basal transcription factors_Homo sapiens_hsa030220.12517955
92Hedgehog signaling pathway_Homo sapiens_hsa043400.12449290
93Dorso-ventral axis formation_Homo sapiens_hsa043200.12094561
94Non-homologous end-joining_Homo sapiens_hsa034500.11883567
95TGF-beta signaling pathway_Homo sapiens_hsa043500.11632329
96Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.11125776
97Hippo signaling pathway_Homo sapiens_hsa043900.08290867
98Glucagon signaling pathway_Homo sapiens_hsa049220.08032064
99Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.07783212
100Taste transduction_Homo sapiens_hsa047420.07516822
101Mineral absorption_Homo sapiens_hsa049780.07067368
102AMPK signaling pathway_Homo sapiens_hsa041520.05949816
103Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.05127268
104Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.03448872
105Basal cell carcinoma_Homo sapiens_hsa052170.02859258
106Phototransduction_Homo sapiens_hsa047440.02481060
107Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.2678911
108Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.2509332
109Renin-angiotensin system_Homo sapiens_hsa04614-0.2470820
110Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2433375
111Purine metabolism_Homo sapiens_hsa00230-0.2363891
112Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014-0.2226040
113Thyroid hormone synthesis_Homo sapiens_hsa04918-0.2117790
114Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1915096
115Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.1811540
116Parkinsons disease_Homo sapiens_hsa05012-0.1796867
117Ether lipid metabolism_Homo sapiens_hsa00565-0.1589922
118Pyrimidine metabolism_Homo sapiens_hsa00240-0.1328929
119Insulin signaling pathway_Homo sapiens_hsa04910-0.1144524
120Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1039459
121Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970-0.0941218
122Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0891547
123Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0579527
124Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0313984

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