NADSYN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Nicotinamide adenine dinucleotide (NAD) is a coenzyme in metabolic redox reactions, a precursor for several cell signaling molecules, and a substrate for protein posttranslational modifications. NAD synthetase (EC 6.3.5.1) catalyzes the final step in the biosynthesis of NAD from nicotinic acid adenine dinucleotide (NaAD). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.64172971
2L-phenylalanine catabolic process (GO:0006559)6.64172971
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.49941327
4L-phenylalanine metabolic process (GO:0006558)6.49941327
5triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.11365746
6aromatic amino acid family catabolic process (GO:0009074)6.02010262
7cysteine metabolic process (GO:0006534)5.54938299
8indole-containing compound catabolic process (GO:0042436)5.52556226
9indolalkylamine catabolic process (GO:0046218)5.52556226
10tryptophan catabolic process (GO:0006569)5.52556226
11positive regulation of gamma-delta T cell activation (GO:0046645)5.51565060
12urea metabolic process (GO:0019627)5.39243678
13urea cycle (GO:0000050)5.39243678
14kynurenine metabolic process (GO:0070189)5.36490727
15glyoxylate metabolic process (GO:0046487)5.34707292
16high-density lipoprotein particle remodeling (GO:0034375)5.25234196
17bile acid biosynthetic process (GO:0006699)5.23488020
18tryptophan metabolic process (GO:0006568)5.19627805
19homocysteine metabolic process (GO:0050667)5.18214831
20sulfur amino acid catabolic process (GO:0000098)5.13873652
21alpha-linolenic acid metabolic process (GO:0036109)4.95629749
22serine family amino acid catabolic process (GO:0009071)4.94524280
23nitrogen cycle metabolic process (GO:0071941)4.92045036
24antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.78415976
25regulation of cholesterol esterification (GO:0010872)4.77308971
26lysine catabolic process (GO:0006554)4.76737616
27lysine metabolic process (GO:0006553)4.76737616
28fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.73926608
29reverse cholesterol transport (GO:0043691)4.70633487
30antigen processing and presentation of endogenous antigen (GO:0019883)4.69492585
31negative regulation of fibrinolysis (GO:0051918)4.67933433
32regulation of triglyceride catabolic process (GO:0010896)4.64851488
33regulation of protein activation cascade (GO:2000257)4.60416545
34protein-lipid complex remodeling (GO:0034368)4.59930520
35macromolecular complex remodeling (GO:0034367)4.59930520
36plasma lipoprotein particle remodeling (GO:0034369)4.59930520
37antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.59177336
38negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.58946016
39negative regulation of cell killing (GO:0031342)4.58946016
40phospholipid efflux (GO:0033700)4.56323580
41bile acid metabolic process (GO:0008206)4.55148085
42regulation of fibrinolysis (GO:0051917)4.54547768
43complement activation, alternative pathway (GO:0006957)4.53456092
44antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.49659072
45glycine metabolic process (GO:0006544)4.44950153
46drug catabolic process (GO:0042737)4.42920379
47amino-acid betaine metabolic process (GO:0006577)4.41978394
48cellular glucuronidation (GO:0052695)4.41350694
49protein carboxylation (GO:0018214)4.39862547
50peptidyl-glutamic acid carboxylation (GO:0017187)4.39862547
51negative regulation of cholesterol transport (GO:0032375)4.39658442
52negative regulation of sterol transport (GO:0032372)4.39658442
53mannose metabolic process (GO:0006013)4.39515999
54regulation of gamma-delta T cell activation (GO:0046643)4.38759319
55aromatic amino acid family metabolic process (GO:0009072)4.36090648
56serine family amino acid metabolic process (GO:0009069)4.35927950
57serine family amino acid biosynthetic process (GO:0009070)4.34175476
58alpha-amino acid catabolic process (GO:1901606)4.29483072
59regulation of complement activation (GO:0030449)4.28612006
60acylglycerol homeostasis (GO:0055090)4.27944510
61triglyceride homeostasis (GO:0070328)4.27944510
62ethanol oxidation (GO:0006069)4.26296464
63detection of bacterium (GO:0016045)4.21131581
64detection of other organism (GO:0098543)4.18381858
65regulation of B cell receptor signaling pathway (GO:0050855)4.16125975
66negative regulation of erythrocyte differentiation (GO:0045647)4.10408258
67regulation of gamma-delta T cell differentiation (GO:0045586)4.10011116
68response to peptidoglycan (GO:0032494)4.09367947
69modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.07557569
70modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.07557569
71positive regulation by organism of defense response of other organism involved in symbiotic interact4.07557569
72modulation by symbiont of host immune response (GO:0052553)4.07557569
73positive regulation by symbiont of host defense response (GO:0052509)4.07557569
74modulation by symbiont of host defense response (GO:0052031)4.07557569
75cholesterol efflux (GO:0033344)4.06797425
76cellular ketone body metabolic process (GO:0046950)4.04708984
77aldehyde catabolic process (GO:0046185)4.02927162
78glucuronate metabolic process (GO:0019585)4.02872875
79uronic acid metabolic process (GO:0006063)4.02872875
80bile acid and bile salt transport (GO:0015721)4.02612543
81plasma lipoprotein particle assembly (GO:0034377)4.02336496
82plasma lipoprotein particle clearance (GO:0034381)4.01668534
83cellular modified amino acid catabolic process (GO:0042219)4.00192678
84cellular amino acid catabolic process (GO:0009063)3.97798516
85positive regulation of triglyceride lipase activity (GO:0061365)3.94111404
86positive regulation of lipoprotein lipase activity (GO:0051006)3.94111404
87tyrosine metabolic process (GO:0006570)3.93805559
88flavonoid metabolic process (GO:0009812)3.93061318
89imidazole-containing compound metabolic process (GO:0052803)3.90568889
90short-chain fatty acid metabolic process (GO:0046459)3.88362371
91intestinal cholesterol absorption (GO:0030299)3.85196775
92glutamate metabolic process (GO:0006536)3.84950803
93indolalkylamine metabolic process (GO:0006586)3.82124457
94exogenous drug catabolic process (GO:0042738)3.80344644
95amine catabolic process (GO:0009310)3.79776991
96cellular biogenic amine catabolic process (GO:0042402)3.79776991
97low-density lipoprotein particle remodeling (GO:0034374)3.78607018
98cholesterol homeostasis (GO:0042632)3.77227778
99neutrophil activation involved in immune response (GO:0002283)3.77054114
100coenzyme catabolic process (GO:0009109)3.76762016
101arginine metabolic process (GO:0006525)3.75124778
102B cell receptor signaling pathway (GO:0050853)3.72068160
103benzene-containing compound metabolic process (GO:0042537)3.70260950
104sterol homeostasis (GO:0055092)3.69430808
105very-low-density lipoprotein particle assembly (GO:0034379)3.69349979
106drug transmembrane transport (GO:0006855)3.69234887
107regulation of bile acid biosynthetic process (GO:0070857)3.68762188
108positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.63810826
109macrophage activation involved in immune response (GO:0002281)3.63565409
110positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.62761719
111dicarboxylic acid biosynthetic process (GO:0043650)3.61304903
112phospholipid homeostasis (GO:0055091)3.61248959
113plasma lipoprotein particle organization (GO:0071827)3.59062783
114heme transport (GO:0015886)3.58687792
115protein-lipid complex assembly (GO:0065005)3.58231681
116aspartate family amino acid catabolic process (GO:0009068)3.58087155
117organic acid catabolic process (GO:0016054)3.57848969
118carboxylic acid catabolic process (GO:0046395)3.57848969
119immunoglobulin mediated immune response (GO:0016064)3.57322280
120blood coagulation, intrinsic pathway (GO:0007597)3.54708033
121lipoprotein metabolic process (GO:0042157)3.54114250
122* nicotinamide nucleotide biosynthetic process (GO:0019359)3.53192590
123* pyridine nucleotide biosynthetic process (GO:0019363)3.53192590
124* NAD biosynthetic process (GO:0009435)3.51436255
125ketone body metabolic process (GO:1902224)3.50800741
126cellular extravasation (GO:0045123)3.50786146
127positive regulation of B cell differentiation (GO:0045579)3.47550503
128urate metabolic process (GO:0046415)3.47448339
129drug transport (GO:0015893)3.47038691
130positive thymic T cell selection (GO:0045059)3.44355919
131response to muramyl dipeptide (GO:0032495)3.44038415
132detection of external biotic stimulus (GO:0098581)3.43124666
133regulation of interferon-beta biosynthetic process (GO:0045357)3.38633067
134response to type I interferon (GO:0034340)3.25344665
135leukocyte aggregation (GO:0070486)3.22033807
136regulation of mast cell degranulation (GO:0043304)3.21592898
137cellular response to type I interferon (GO:0071357)3.19830076
138type I interferon signaling pathway (GO:0060337)3.19830076
139negative regulation of interleukin-12 production (GO:0032695)3.18872427
140positive regulation of Cdc42 GTPase activity (GO:0043089)3.17657622
141germinal center formation (GO:0002467)3.15948244
142negative regulation of lymphocyte mediated immunity (GO:0002707)3.12628756
143thymic T cell selection (GO:0045061)3.11485626
144negative thymic T cell selection (GO:0045060)3.11103967
145regulation of B cell differentiation (GO:0045577)3.08827978
146T cell selection (GO:0045058)3.08122937
147regulation of myeloid leukocyte mediated immunity (GO:0002886)3.07748985
148regulation of dendritic cell antigen processing and presentation (GO:0002604)3.01997577
149negative regulation of leukocyte mediated immunity (GO:0002704)3.00375635
150neutrophil activation (GO:0042119)3.00041128
151regulation of leukocyte degranulation (GO:0043300)2.99839658
152negative T cell selection (GO:0043383)2.98523232
153interferon-gamma-mediated signaling pathway (GO:0060333)2.97673157
154regulation of mast cell activation involved in immune response (GO:0033006)2.97480412
155positive regulation of interferon-alpha production (GO:0032727)2.96616412
156detection of biotic stimulus (GO:0009595)2.94753975
157negative regulation of T cell mediated immunity (GO:0002710)2.92327187
158positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.89052880
159detection of molecule of bacterial origin (GO:0032490)2.88733505
160regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.85660046
161response to interleukin-15 (GO:0070672)2.83892533
162response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.83744397
163response to host immune response (GO:0052572)2.83744397
164NIK/NF-kappaB signaling (GO:0038061)2.83399364
165positive regulation of granulocyte differentiation (GO:0030854)2.81758652
166myeloid cell activation involved in immune response (GO:0002275)2.79557672
167phospholipid scrambling (GO:0017121)2.78463925
168regulation of interferon-alpha production (GO:0032647)2.76052932
169granulocyte activation (GO:0036230)2.75513272
170positive T cell selection (GO:0043368)2.74335039
171regulation of antigen processing and presentation (GO:0002577)2.74113250
172positive regulation of antigen processing and presentation (GO:0002579)2.73109314
173regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.72800579
174positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.72157205
175response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.69937203
176response to host (GO:0075136)2.69937203
177response to host defenses (GO:0052200)2.69937203
178negative regulation of interleukin-6 production (GO:0032715)2.69235728
179respiratory burst (GO:0045730)2.68637250
180defense response to protozoan (GO:0042832)2.66139191
181regulation of necroptotic process (GO:0060544)2.64924856
182B cell mediated immunity (GO:0019724)2.62822585
183antigen processing and presentation via MHC class Ib (GO:0002475)2.61593252
184response to protozoan (GO:0001562)2.59499098
185regulation of mast cell activation (GO:0033003)2.58708141
186macrophage activation (GO:0042116)2.57908523
187positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.56522252
188lipopolysaccharide-mediated signaling pathway (GO:0031663)2.56212383
189regulation of type I interferon-mediated signaling pathway (GO:0060338)2.56131571
190negative regulation of innate immune response (GO:0045824)2.55874637
191T cell migration (GO:0072678)2.54843048
192regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.53958705
193Arp2/3 complex-mediated actin nucleation (GO:0034314)2.50936784
194interferon-gamma secretion (GO:0072643)2.50926229
195microglial cell activation (GO:0001774)2.46861263
196regulation of granulocyte differentiation (GO:0030852)2.46237506
197negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.45804333
198positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.43443450
199negative regulation of cytokine production involved in immune response (GO:0002719)2.42116784
200regulation of alpha-beta T cell proliferation (GO:0046640)2.41732807

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.30597021
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.51220998
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.32382882
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.61601027
5CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.82633418
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.61951711
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.56385765
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.06261706
9VDR_21846776_ChIP-Seq_THP-1_Human3.24832508
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.24116325
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.81006244
12MYC_22102868_ChIP-Seq_BL_Human2.79169346
13VDR_24763502_ChIP-Seq_THP-1_Human2.60326031
14VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.54694550
15HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.50275002
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.43904492
17IRF8_22096565_ChIP-ChIP_GC-B_Human2.32782997
18TCF7_22412390_ChIP-Seq_EML_Mouse2.17599029
19SPI1_23127762_ChIP-Seq_K562_Human2.16637720
20KDM2B_26808549_Chip-Seq_SUP-B15_Human2.14839382
21KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.07080334
22ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.4967864
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.98050049
24SPI1_23547873_ChIP-Seq_NB4_Human1.93591760
25TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.92069209
26TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.90747507
27ELK3_25401928_ChIP-Seq_HUVEC_Human1.90148525
28GATA1_22025678_ChIP-Seq_K562_Human1.89500699
29FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.86615018
30IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.85168366
31* MYB_26560356_Chip-Seq_TH2_Human1.79991107
32STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.76686021
33* KDM2B_26808549_Chip-Seq_DND41_Human1.75572727
34STAT4_19710469_ChIP-ChIP_TH1__Mouse1.73210474
35* MAF_26560356_Chip-Seq_TH2_Human1.71551975
36EGR1_19374776_ChIP-ChIP_THP-1_Human1.70701228
37FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.69180073
38NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.63451805
39KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.60450647
40MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.59100323
41TP63_17297297_ChIP-ChIP_HaCaT_Human1.57000613
42STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.53884467
43GATA1_19941826_ChIP-Seq_K562_Human1.42636076
44VDR_24787735_ChIP-Seq_THP-1_Human1.39159128
45TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.38367135
46STAT6_21828071_ChIP-Seq_BEAS2B_Human1.37849973
47HNF4A_19822575_ChIP-Seq_HepG2_Human1.36152154
48ESR2_21235772_ChIP-Seq_MCF-7_Human1.35295564
49LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.34978827
50TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.33991048
51GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30336646
52GATA3_27048872_Chip-Seq_THYMUS_Human1.29304873
53FOXA2_19822575_ChIP-Seq_HepG2_Human1.27422405
54ELF1_20517297_ChIP-Seq_JURKAT_Human1.25801593
55P68_20966046_ChIP-Seq_HELA_Human1.24899257
56CLOCK_20551151_ChIP-Seq_293T_Human1.24092674
57PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23658454
58NCOR1_26117541_ChIP-Seq_K562_Human1.21783242
59THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.21264461
60SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21069044
61ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.19559656
62GATA2_21666600_ChIP-Seq_HMVEC_Human1.19378351
63GATA4_25053715_ChIP-Seq_YYC3_Human1.19163877
64PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18485033
65SOX2_27498859_Chip-Seq_STOMACH_Mouse1.18435449
66CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.17484641
67NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.15698661
68CTCF_27219007_Chip-Seq_ERYTHROID_Human1.15506269
69* RUNX1_27514584_Chip-Seq_MCF-7_Human1.13987878
70STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.13602192
71PU.1_20513432_ChIP-Seq_Bcells_Mouse1.11303353
72EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.10542757
73GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08863626
74SA1_27219007_Chip-Seq_ERYTHROID_Human1.08600707
75RXRA_24833708_ChIP-Seq_LIVER_Mouse1.07851262
76IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.07527997
77VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.06425068
78ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.04800204
79KDM2B_26808549_Chip-Seq_JURKAT_Human1.03891425
80* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.02885018
81TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02872916
82* SMC4_20622854_ChIP-Seq_HELA_Human1.02501226
83HTT_18923047_ChIP-ChIP_STHdh_Human1.02035279
84CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.01502006
85KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01456783
86STAT3_1855785_ChIP-Seq_MESCs_Mouse0.98491570
87NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.98038905
88RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.97633363
89SCL_19346495_ChIP-Seq_HPC-7_Human0.97029162
90ELF1_17652178_ChIP-ChIP_JURKAT_Human0.95174874
91RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.93478773
92TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.90720718
93* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.90259146
94ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90153868
95SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.89691291
96CDX2_20551321_ChIP-Seq_CACO-2_Human0.89637360
97AR_21909140_ChIP-Seq_LNCAP_Human0.85476670
98SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.84207292
99BRD4_27068464_Chip-Seq_AML-cells_Mouse0.80208224
100GATA6_25053715_ChIP-Seq_YYC3_Human0.80077179
101RARA_24833708_ChIP-Seq_LIVER_Mouse0.78455838
102PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.76126686
103GATA1_22383799_ChIP-Seq_G1ME_Mouse0.75948383
104CEBPB_22108803_ChIP-Seq_LS180_Human0.75669792
105BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.74364478
106* SRF_21415370_ChIP-Seq_HL-1_Mouse0.72717034
107CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.71761392
108IRF8_27001747_Chip-Seq_BMDM_Mouse0.71101823
109GATA1_19941827_ChIP-Seq_MEL_Mouse0.69694188
110RARB_24833708_ChIP-Seq_LIVER_Mouse0.69368275
111AR_20517297_ChIP-Seq_VCAP_Human0.68665614
112NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.68587650
113Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.68096449
114* MYB_26560356_Chip-Seq_TH1_Human0.67754123
115ZNF263_19887448_ChIP-Seq_K562_Human0.67490300
116FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.67315149
117IRF8_21731497_ChIP-ChIP_J774_Mouse0.67267289
118LXR_22292898_ChIP-Seq_THP-1_Human0.65881413
119GATA2_22383799_ChIP-Seq_G1ME_Mouse0.65661307
120SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.65629359
121* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.65032242
122KAP1_22055183_ChIP-Seq_ESCs_Mouse0.64878956
123CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.63953343
124E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.63753882
125PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.63728347
126ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.62855411
127SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.62099778
128SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.61377941
129MAF_26560356_Chip-Seq_TH1_Human0.61328774
130AUTS2_25519132_ChIP-Seq_293T-REX_Human0.60738266
131RARG_19884340_ChIP-ChIP_MEFs_Mouse0.60266823
132GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.60096186
133PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.56708851
134* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.56437863
135GATA2_19941826_ChIP-Seq_K562_Human0.56255226
136BCL6_27268052_Chip-Seq_Bcells_Human0.55537813
137CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.54724209
138CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.53774214
139TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.53533619
140UTX_26944678_Chip-Seq_JUKART_Human0.52235702
141MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.51553296
142CTCF_26484167_Chip-Seq_Bcells_Mouse0.50113406
143RAD21_21589869_ChIP-Seq_MESCs_Mouse0.50056813
144RACK7_27058665_Chip-Seq_MCF-7_Human0.49035591
145SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.48836577
146RUNX_20019798_ChIP-Seq_JUKART_Human0.48360752
147RUNX1_22412390_ChIP-Seq_EML_Mouse0.47913440
148CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.47730258
149CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.47620909
150SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.47580031
151SALL4_18804426_ChIP-ChIP_XEN_Mouse0.47526191
152MYB_21317192_ChIP-Seq_ERMYB_Mouse0.47318194
153P53_21459846_ChIP-Seq_SAOS-2_Human0.46801793
154P300_27268052_Chip-Seq_Bcells_Human0.46592138
155LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.46328483
156BCOR_27268052_Chip-Seq_Bcells_Human0.46278444

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.48503647
2MP0002139_abnormal_hepatobiliary_system7.31353270
3MP0005085_abnormal_gallbladder_physiolo5.74278041
4MP0005365_abnormal_bile_salt5.62968486
5MP0008875_abnormal_xenobiotic_pharmacok4.90072795
6MP0003806_abnormal_nucleotide_metabolis4.05282554
7MP0003252_abnormal_bile_duct3.70130562
8MP0010329_abnormal_lipoprotein_level3.38287580
9MP0009840_abnormal_foam_cell3.29353141
10MP0003303_peritoneal_inflammation3.12852924
11MP0001666_abnormal_nutrient_absorption2.93655089
12MP0005332_abnormal_amino_acid2.83561108
13MP0005083_abnormal_biliary_tract2.66506480
14MP0003172_abnormal_lysosome_physiology2.62258631
15MP0005671_abnormal_response_to2.52502225
16MP0005000_abnormal_immune_tolerance2.39795536
17MP0003191_abnormal_cellular_cholesterol2.31049174
18MP0003763_abnormal_thymus_physiology2.27376042
19MP0002452_abnormal_antigen_presenting2.25894186
20MP0002723_abnormal_immune_serum2.24594137
21MP0009278_abnormal_bone_marrow2.16985878
22MP0002420_abnormal_adaptive_immunity2.15489777
23MP0001819_abnormal_immune_cell2.15290640
24MP0003195_calcinosis2.14042802
25MP0004019_abnormal_vitamin_homeostasis2.13536907
26MP0000609_abnormal_liver_physiology2.12064357
27MP0002396_abnormal_hematopoietic_system2.08858278
28MP0002138_abnormal_hepatobiliary_system1.94356008
29MP0002148_abnormal_hypersensitivity_rea1.86674622
30MP0002118_abnormal_lipid_homeostasis1.85346843
31MP0001764_abnormal_homeostasis1.83274567
32MP0005397_hematopoietic_system_phenotyp1.82012897
33MP0001545_abnormal_hematopoietic_system1.82012897
34MP0001533_abnormal_skeleton_physiology1.81264892
35MP0005319_abnormal_enzyme/_coenzyme1.77218164
36MP0002405_respiratory_system_inflammati1.72013514
37MP0000716_abnormal_immune_system1.69359322
38MP0002398_abnormal_bone_marrow1.68932815
39MP0009333_abnormal_splenocyte_physiolog1.66526054
40MP0003183_abnormal_peptide_metabolism1.64421953
41MP0008260_abnormal_autophagy1.61725306
42MP0009643_abnormal_urine_homeostasis1.60052599
43MP0005310_abnormal_salivary_gland1.59775907
44MP0003866_abnormal_defecation1.57811394
45MP0004381_abnormal_hair_follicle1.57120348
46MP0005584_abnormal_enzyme/coenzyme_acti1.53907738
47MP0003868_abnormal_feces_composition1.49991640
48MP0003011_delayed_dark_adaptation1.45786534
49MP0003186_abnormal_redox_activity1.43893966
50MP0002722_abnormal_immune_system1.43054919
51MP0009697_abnormal_copulation1.40569261
52MP0002429_abnormal_blood_cell1.39941089
53MP0002998_abnormal_bone_remodeling1.37130534
54MP0003656_abnormal_erythrocyte_physiolo1.29125748
55MP0003045_fibrosis1.26124903
56MP0009764_decreased_sensitivity_to1.25034072
57MP0005076_abnormal_cell_differentiation1.23395243
58MP0000598_abnormal_liver_morphology1.22951888
59MP0000703_abnormal_thymus_morphology1.19484315
60MP0004808_abnormal_hematopoietic_stem1.17516479
61MP0000858_altered_metastatic_potential1.16335066
62MP0001851_eye_inflammation1.16239115
63MP0005451_abnormal_body_composition1.16187209
64MP0005636_abnormal_mineral_homeostasis1.14553592
65MP0003705_abnormal_hypodermis_morpholog1.10502096
66MP0008469_abnormal_protein_level1.09586672
67MP0003828_pulmonary_edema1.08648512
68MP0009763_increased_sensitivity_to1.05577434
69MP0009384_cardiac_valve_regurgitation1.04876949
70MP0002933_joint_inflammation1.03706150
71MP0006036_abnormal_mitochondrial_physio1.02591971
72MP0004264_abnormal_extraembryonic_tissu1.01140218
73MP0006054_spinal_hemorrhage1.00541772
74MP0000604_amyloidosis0.99914035
75MP0002132_abnormal_respiratory_system0.98853688
76MP0003300_gastrointestinal_ulcer0.98689381
77MP0005647_abnormal_sex_gland0.95429741
78MP0000015_abnormal_ear_pigmentation0.93696245
79MP0003453_abnormal_keratinocyte_physiol0.92668268
80MP0004883_abnormal_blood_vessel0.91932304
81MP0009642_abnormal_blood_homeostasis0.91100524
82MP0009765_abnormal_xenobiotic_induced0.88850705
83MP0003724_increased_susceptibility_to0.87930128
84MP0005670_abnormal_white_adipose0.84620156
85MP0005464_abnormal_platelet_physiology0.84501186
86MP0005408_hypopigmentation0.81349458
87MP0004147_increased_porphyrin_level0.80672795
88MP0005220_abnormal_exocrine_pancreas0.80417517
89MP0005376_homeostasis/metabolism_phenot0.79695666
90MP0010155_abnormal_intestine_physiology0.78011479
91MP0002136_abnormal_kidney_physiology0.77018033
92MP0003075_altered_response_to0.76700732
93MP0001849_ear_inflammation0.75399606
94MP0005084_abnormal_gallbladder_morpholo0.75280509
95MP0008004_abnormal_stomach_pH0.74646683
96MP0000490_abnormal_crypts_of0.74253418
97MP0005164_abnormal_response_to0.73698781
98MP0005390_skeleton_phenotype0.72367250
99MP0001853_heart_inflammation0.71187767
100MP0004510_myositis0.69857819
101MP0003091_abnormal_cell_migration0.69765883
102MP0005266_abnormal_metabolism0.69586728
103MP0002796_impaired_skin_barrier0.68875016
104MP0009379_abnormal_foot_pigmentation0.67446011
105MP0004130_abnormal_muscle_cell0.67411702
106MP0001845_abnormal_inflammatory_respons0.67175766
107MP0002078_abnormal_glucose_homeostasis0.66385572
108MP0002971_abnormal_brown_adipose0.66139373
109MP0003795_abnormal_bone_structure0.65866021
110MP0000371_diluted_coat_color0.65670909
111MP0001756_abnormal_urination0.65666802
112MP0003436_decreased_susceptibility_to0.65234613
113MP0001835_abnormal_antigen_presentation0.64793813
114MP0002006_tumorigenesis0.64178450
115MP0005377_hearing/vestibular/ear_phenot0.63875425
116MP0003878_abnormal_ear_physiology0.63875425
117MP0004185_abnormal_adipocyte_glucose0.63736543
118MP0002876_abnormal_thyroid_physiology0.63490311
119MP0000685_abnormal_immune_system0.63040274
120MP0000470_abnormal_stomach_morphology0.61690793
121MP0005381_digestive/alimentary_phenotyp0.61485731
122MP0001873_stomach_inflammation0.61364408
123MP0002254_reproductive_system_inflammat0.60729020
124MP0005025_abnormal_response_to0.58318446
125MP0009785_altered_susceptibility_to0.56018020
126MP0005334_abnormal_fat_pad0.55123447
127MP0001800_abnormal_humoral_immune0.53370952
128MP0008873_increased_physiological_sensi0.51645335
129MP0010234_abnormal_vibrissa_follicle0.50415258
130MP0006082_CNS_inflammation0.50342945
131MP0002419_abnormal_innate_immunity0.48828966
132MP0001663_abnormal_digestive_system0.48231841
133MP0000477_abnormal_intestine_morphology0.48157028
134MP0005058_abnormal_lysosome_morphology0.47694819
135MP0005448_abnormal_energy_balance0.47514910
136MP0002928_abnormal_bile_duct0.46299598
137MP0000465_gastrointestinal_hemorrhage0.45797868
138MP0005666_abnormal_adipose_tissue0.44180343
139MP0004043_abnormal_pH_regulation0.43215328
140MP0005535_abnormal_body_temperature0.42500945
141MP0003718_maternal_effect0.42215579
142MP0004947_skin_inflammation0.42131947
143MP0008872_abnormal_physiological_respon0.41558121
144MP0003638_abnormal_response/metabolism_0.40714886
145MP0000249_abnormal_blood_vessel0.40560177
146MP0003690_abnormal_glial_cell0.39694931
147MP0009115_abnormal_fat_cell0.39406682
148MP0002166_altered_tumor_susceptibility0.38094679
149MP0005166_decreased_susceptibility_to0.37826174
150MP0005075_abnormal_melanosome_morpholog0.37776240
151MP0005023_abnormal_wound_healing0.36890896
152MP0001790_abnormal_immune_system0.36829305
153MP0005387_immune_system_phenotype0.36829305
154MP0000689_abnormal_spleen_morphology0.35836272

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.40199012
2Intrahepatic cholestasis (HP:0001406)6.31997535
3Hypobetalipoproteinemia (HP:0003563)5.94450117
4Deep venous thrombosis (HP:0002625)5.90523971
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.80810815
6Xanthomatosis (HP:0000991)5.59818532
7Prolonged partial thromboplastin time (HP:0003645)5.35226883
8Eczematoid dermatitis (HP:0000976)5.10686387
9Abnormality of glutamine family amino acid metabolism (HP:0010902)4.59586932
10Hyperammonemia (HP:0001987)4.48440176
11Recurrent abscess formation (HP:0002722)4.48315522
12Recurrent bacterial skin infections (HP:0005406)4.48107314
13Hyperglycinemia (HP:0002154)4.44775929
14Hyperlipoproteinemia (HP:0010980)4.41867481
15Hypolipoproteinemia (HP:0010981)4.38880419
16Complement deficiency (HP:0004431)4.28939043
17Hyperglycinuria (HP:0003108)4.23780564
18Abnormality of macrophages (HP:0004311)4.17993844
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.16939035
20Abnormality of serine family amino acid metabolism (HP:0010894)4.12318897
21Abnormality of glycine metabolism (HP:0010895)4.12318897
22Joint hemorrhage (HP:0005261)4.04457158
23Abnormality of aspartate family amino acid metabolism (HP:0010899)4.03562870
24Hypoglycemic coma (HP:0001325)3.95763883
25Ketosis (HP:0001946)3.94214081
26Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.92640709
27Increased cerebral lipofuscin (HP:0011813)3.87205433
28Fat malabsorption (HP:0002630)3.86381686
29Increased neuronal autofluorescent lipopigment (HP:0002074)3.80628217
30Abnormality of pyrimidine metabolism (HP:0004353)3.80421542
31Abnormality of the common coagulation pathway (HP:0010990)3.79639440
32Myositis (HP:0100614)3.73698836
33Abnormality of methionine metabolism (HP:0010901)3.73407919
34Conjugated hyperbilirubinemia (HP:0002908)3.66902718
35Epidermoid cyst (HP:0200040)3.66140067
36Hypoalphalipoproteinemia (HP:0003233)3.64604112
37Abnormal delayed hypersensitivity skin test (HP:0002963)3.58208987
38Colitis (HP:0002583)3.53729043
39Recurrent fungal infections (HP:0002841)3.52900797
40Increased IgE level (HP:0003212)3.48860112
41Abnormality of fatty-acid metabolism (HP:0004359)3.42405254
42Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.41853730
43Hypercholesterolemia (HP:0003124)3.36998688
44Elevated erythrocyte sedimentation rate (HP:0003565)3.36767286
45Inflammation of the large intestine (HP:0002037)3.32748473
46Gastrointestinal inflammation (HP:0004386)3.31931658
47Gastrointestinal infarctions (HP:0005244)3.30454776
48Hyperbilirubinemia (HP:0002904)3.28764089
49Abnormality of nucleobase metabolism (HP:0010932)3.28056080
50Dysostosis multiplex (HP:0000943)3.27293808
51Obstructive lung disease (HP:0006536)3.23659521
52Chronic obstructive pulmonary disease (HP:0006510)3.23659521
53Orchitis (HP:0100796)3.21660980
54Meningitis (HP:0001287)3.21585244
55Mediastinal lymphadenopathy (HP:0100721)3.19239682
56Prolonged bleeding time (HP:0003010)3.15939650
57Pustule (HP:0200039)3.13344827
58Abnormality of serum amino acid levels (HP:0003112)3.11568906
59Abnormality of complement system (HP:0005339)3.11216914
60Recurrent skin infections (HP:0001581)3.10715972
61Abnormality of the intrinsic pathway (HP:0010989)3.10655454
62Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.09944050
63Recurrent cutaneous fungal infections (HP:0011370)3.07731833
64Chronic mucocutaneous candidiasis (HP:0002728)3.07731833
65Abnormality of dicarboxylic acid metabolism (HP:0010995)3.03994536
66Dicarboxylic aciduria (HP:0003215)3.03994536
67Abnormality of purine metabolism (HP:0004352)3.01873349
68Generalized aminoaciduria (HP:0002909)3.01000790
69Gingivitis (HP:0000230)2.95736723
70Vasculitis (HP:0002633)2.92259959
71Delayed CNS myelination (HP:0002188)2.92028851
72Recurrent viral infections (HP:0004429)2.90828026
73Metabolic acidosis (HP:0001942)2.86580045
74Stomatitis (HP:0010280)2.86304911
75Cellulitis (HP:0100658)2.83466583
76Panhypogammaglobulinemia (HP:0003139)2.83191818
77Optic neuritis (HP:0100653)2.80076854
78Retrobulbar optic neuritis (HP:0100654)2.80076854
79Agammaglobulinemia (HP:0004432)2.79791451
80Epistaxis (HP:0000421)2.78519159
81Hepatocellular carcinoma (HP:0001402)2.77029363
82Acanthocytosis (HP:0001927)2.76934880
83Steatorrhea (HP:0002570)2.76724284
84Ketoacidosis (HP:0001993)2.76407309
85Autoimmune thrombocytopenia (HP:0001973)2.74122591
86Spontaneous hematomas (HP:0007420)2.74022495
87Myocardial infarction (HP:0001658)2.69046917
88Urinary glycosaminoglycan excretion (HP:0003541)2.68928598
89Mucopolysacchariduria (HP:0008155)2.68928598
90Abnormality of mucopolysaccharide metabolism (HP:0011020)2.68049981
91Abnormality of polysaccharide metabolism (HP:0011012)2.68049981
92Abnormality of glycosaminoglycan metabolism (HP:0004371)2.68049981
93Systemic lupus erythematosus (HP:0002725)2.61840898
94Lethargy (HP:0001254)2.60581460
95Malnutrition (HP:0004395)2.56245338
96Abnormality of T cell physiology (HP:0011840)2.54681666
97Hydroxyprolinuria (HP:0003080)2.48384875
98Abnormality of proline metabolism (HP:0010907)2.48384875
99Hypochromic anemia (HP:0001931)2.48197452
100Proximal tubulopathy (HP:0000114)2.46913578
101Abnormality of glycosphingolipid metabolism (HP:0004343)2.46247062
102Abnormality of glycolipid metabolism (HP:0010969)2.46247062
103Abnormality of liposaccharide metabolism (HP:0010968)2.46247062
104Spontaneous abortion (HP:0005268)2.45234901
105Encephalitis (HP:0002383)2.44956079
106Chest pain (HP:0100749)2.44652291
107Abnormality of the fingertips (HP:0001211)2.44546918
108Vascular calcification (HP:0004934)2.44406867
109Chronic diarrhea (HP:0002028)2.42646324
110Gout (HP:0001997)2.42512496
111Gastrointestinal stroma tumor (HP:0100723)2.40054236
112Osteomyelitis (HP:0002754)2.37346235
113Loss of speech (HP:0002371)2.36654370
114Petechiae (HP:0000967)2.35989155
115Increased serum ferritin (HP:0003281)2.35489831
116Urticaria (HP:0001025)2.35151443
117Vacuolated lymphocytes (HP:0001922)2.34668168
118Pulmonary infiltrates (HP:0002113)2.33799700
119Hemoptysis (HP:0002105)2.33535257
120Abnormality of T cells (HP:0002843)2.33372709
121Esophageal varix (HP:0002040)2.32566554
122Spastic diplegia (HP:0001264)2.27674351
123Gingival bleeding (HP:0000225)2.26842680
124Irritability (HP:0000737)2.25678286
125Skin nodule (HP:0200036)2.25485275
126Granulocytopenia (HP:0001913)2.23052739
127Renal cortical cysts (HP:0000803)2.18615142
128Hypochromic microcytic anemia (HP:0004840)2.17705969
129Abnormality of vitamin metabolism (HP:0100508)2.16554972
130Hypoglycemic seizures (HP:0002173)2.16397440
131Cardiovascular calcification (HP:0011915)2.15855049
132Thrombophlebitis (HP:0004418)2.15788833
133Menorrhagia (HP:0000132)2.15221963
134Abnormality of urine glucose concentration (HP:0011016)2.15214496
135Glycosuria (HP:0003076)2.15214496
136Late onset (HP:0003584)2.14406094
137Pancreatitis (HP:0001733)2.13648169
138Cerebral edema (HP:0002181)2.13629964
139Arterial thrombosis (HP:0004420)2.13381988
140J-shaped sella turcica (HP:0002680)2.13002931
141Vomiting (HP:0002013)2.12411917
142Recurrent gram-negative bacterial infections (HP:0005420)2.11850598
143Keratoconjunctivitis sicca (HP:0001097)2.11425502
144Glomerulonephritis (HP:0000099)2.11226864
145Opisthotonus (HP:0002179)2.10619537
146Poikilocytosis (HP:0004447)2.09155261
147Cholecystitis (HP:0001082)2.08851275
148Abnormal gallbladder physiology (HP:0012438)2.08851275
149Mitral stenosis (HP:0001718)2.08686096
150Abnormality of transition element cation homeostasis (HP:0011030)2.05815166
151Lymphopenia (HP:0001888)2.05679915
152Viral hepatitis (HP:0006562)2.04432826
153Nausea (HP:0002018)2.03255001
154Purpura (HP:0000979)2.02094946
155Abnormality of T cell number (HP:0011839)2.01702109
156Autoimmune hemolytic anemia (HP:0001890)2.01188548
157T lymphocytopenia (HP:0005403)2.00950710
158Abnormal gallbladder morphology (HP:0012437)2.00137527
159Polygenic inheritance (HP:0010982)1.98698084
160Emphysema (HP:0002097)1.98604246
161Hypergammaglobulinemia (HP:0010702)1.98440854
162Abnormality of iron homeostasis (HP:0011031)1.98176727
163Elevated hepatic transaminases (HP:0002910)1.97707006
164Cholelithiasis (HP:0001081)1.96910427
165Neonatal onset (HP:0003623)1.96537501
166Abnormal enzyme/coenzyme activity (HP:0012379)1.95966841
167Restrictive lung disease (HP:0002091)1.95636829
168Amyloidosis (HP:0011034)1.95041831
169Pulmonary embolism (HP:0002204)1.94135807
170Abnormality of cells of the lymphoid lineage (HP:0012140)1.93801207
171Hypertensive crisis (HP:0100735)1.92457967
172Peritonitis (HP:0002586)1.91609480
173IgM deficiency (HP:0002850)1.91574600
174Papilloma (HP:0012740)1.91432168
175Verrucae (HP:0200043)1.91432168
176Hemorrhage of the eye (HP:0011885)1.90512208
177Leukocytosis (HP:0001974)1.90401974
178Hepatic necrosis (HP:0002605)1.89357699
179Keratoconjunctivitis (HP:0001096)1.88915311
180Interstitial pulmonary disease (HP:0006530)1.87999184
181Increased purine levels (HP:0004368)1.86664661
182Hyperuricemia (HP:0002149)1.86664661
183Abnormality of the peritoneum (HP:0002585)1.86207391
184Flat acetabular roof (HP:0003180)1.85814934
185Thin bony cortex (HP:0002753)1.83537832
186Increased mean platelet volume (HP:0011877)1.83522801
187Abnormal cartilage morphology (HP:0002763)1.83398458
188Skin ulcer (HP:0200042)1.82759634
189Megaloblastic anemia (HP:0001889)1.82749089
190Thrombocytosis (HP:0001894)1.82714040
191Alkalosis (HP:0001948)1.82143539
192Nephritis (HP:0000123)1.77242421

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.54363491
2ERN13.77902598
3FGFR43.54493147
4RIPK43.46677813
5TAOK32.72846026
6SIK12.70809142
7PRPF4B2.61034582
8MST1R2.48404764
9TNK22.43267444
10MAP4K12.35300883
11INSRR2.30582058
12PKN22.15023207
13TYK22.11442175
14EPHA32.07280715
15MAPK111.96221347
16FLT31.95020584
17GRK61.93674499
18MAP2K31.85627690
19SMG11.75279621
20LATS11.66314384
21MUSK1.66105867
22TGFBR21.64015433
23FES1.63844119
24TBK11.60941174
25MAP2K61.57936370
26ERBB41.51667527
27MAP3K141.51527703
28IRAK31.50789916
29PTK61.49381621
30NEK91.45250368
31STK38L1.41337341
32KDR1.41195929
33SCYL21.37272366
34MAP3K111.34772976
35CDC42BPA1.32440413
36IKBKE1.30400592
37MAP3K101.29606840
38KIT1.25616173
39FRK1.25192316
40SIK21.21386078
41HCK1.20201287
42TRIB31.18951158
43STK101.17995793
44PIK3CG1.17837979
45FGR1.05403151
46ICK1.04973812
47JAK11.04621304
48SIK31.03357546
49JAK31.01595445
50MAP3K31.01028315
51NUAK10.99150460
52ZAP700.98652531
53IRAK40.98441108
54MAP3K130.97574526
55PRKD20.97517764
56PDK10.97506787
57STK160.95214921
58PDPK10.94844781
59JAK20.94051771
60PRKAA20.93598956
61ERBB20.93497127
62MAP3K70.93019319
63HIPK20.91206132
64CDK40.90835893
65ACVR1B0.90500414
66FGFR30.89810863
67TGFBR10.88618260
68MARK30.88272421
69CDK60.88251265
70TAOK10.88102550
71MAP2K40.87807266
72MAPK150.87126183
73ITK0.84449312
74CSF1R0.79293121
75BTK0.79255203
76MARK20.78980965
77TLK10.77919918
78BLK0.71736995
79CHUK0.70765063
80RPS6KL10.70443593
81RPS6KC10.70443593
82LRRK20.70192098
83EPHB10.69369355
84CSK0.68407819
85PRKG20.65770771
86IRAK10.65757852
87RPS6KA20.63828753
88TEC0.63221966
89RPS6KA60.63184127
90MYLK0.63162718
91MAP3K60.61826786
92BMX0.60201621
93IKBKB0.59193973
94NME20.58975789
95CDK120.57903539
96ABL20.56569644
97MAPK40.55370532
98MAP3K80.55144865
99NLK0.53235353
100IRAK20.52674121
101TXK0.52109367
102RET0.49770063
103MAP2K20.48703990
104MAPK120.48589540
105MAPKAPK20.48486819
106MELK0.47966255
107BMPR20.47078041
108MAPK70.46862732
109MTOR0.46276549
110LYN0.45351993
111MST40.45142655
112NEK20.44899071
113LCK0.44506965
114SYK0.44127347
115PTK2B0.43928416
116TESK20.41823383
117PRKAA10.41571149
118MET0.41009198
119LMTK20.40993582
120TAOK20.40491626
121TTK0.39329116
122EPHA20.39158313
123TRPM70.38905048
124PIM10.37947285
125DYRK1B0.37473449
126YES10.37402171
127MAP3K10.37346967
128PIK3CA0.36861689
129MATK0.36461631
130MAPK30.35852280
131RIPK10.32495019
132GSK3A0.32468094
133IGF1R0.32130720
134PRKCQ0.30657024
135PRKACG0.30149979
136EEF2K0.29462982
137CDK90.28368056

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.95119453
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.32853243
3Nitrogen metabolism_Homo sapiens_hsa009102.82223411
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.82012220
5Arginine biosynthesis_Homo sapiens_hsa002202.72199316
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.58204534
7Fatty acid degradation_Homo sapiens_hsa000712.57025730
8Tryptophan metabolism_Homo sapiens_hsa003802.54077855
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.51608607
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.48906665
11Leishmaniasis_Homo sapiens_hsa051402.46942612
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.37863700
13Complement and coagulation cascades_Homo sapiens_hsa046102.35681251
14Allograft rejection_Homo sapiens_hsa053302.35488074
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.33713264
16Osteoclast differentiation_Homo sapiens_hsa043802.33043810
17Graft-versus-host disease_Homo sapiens_hsa053322.32401868
18B cell receptor signaling pathway_Homo sapiens_hsa046622.28842605
19Autoimmune thyroid disease_Homo sapiens_hsa053202.15824480
20Peroxisome_Homo sapiens_hsa041462.03712231
21Butanoate metabolism_Homo sapiens_hsa006502.02960575
22Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.02163492
23Histidine metabolism_Homo sapiens_hsa003401.95120052
24Acute myeloid leukemia_Homo sapiens_hsa052211.95017631
25Propanoate metabolism_Homo sapiens_hsa006401.92623762
26Caffeine metabolism_Homo sapiens_hsa002321.91597135
27Asthma_Homo sapiens_hsa053101.87396762
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.82752956
29Folate biosynthesis_Homo sapiens_hsa007901.81643540
30Chemical carcinogenesis_Homo sapiens_hsa052041.80159014
31Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.78907622
32PPAR signaling pathway_Homo sapiens_hsa033201.76953929
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.76610998
34Selenocompound metabolism_Homo sapiens_hsa004501.76560267
35Drug metabolism - other enzymes_Homo sapiens_hsa009831.76547777
36beta-Alanine metabolism_Homo sapiens_hsa004101.76365867
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.75873761
38Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.73785514
39Fatty acid metabolism_Homo sapiens_hsa012121.72613878
40Tuberculosis_Homo sapiens_hsa051521.69273019
41Retinol metabolism_Homo sapiens_hsa008301.69101795
42Type I diabetes mellitus_Homo sapiens_hsa049401.65664409
43Steroid hormone biosynthesis_Homo sapiens_hsa001401.64596110
44Staphylococcus aureus infection_Homo sapiens_hsa051501.59070048
45Toll-like receptor signaling pathway_Homo sapiens_hsa046201.58271266
46Cyanoamino acid metabolism_Homo sapiens_hsa004601.57797316
47Sulfur metabolism_Homo sapiens_hsa009201.55817402
48Toxoplasmosis_Homo sapiens_hsa051451.55064867
49Influenza A_Homo sapiens_hsa051641.54354078
50Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.50172442
51Fat digestion and absorption_Homo sapiens_hsa049751.47494295
52Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.45891979
53Pyruvate metabolism_Homo sapiens_hsa006201.45232739
54Antigen processing and presentation_Homo sapiens_hsa046121.45028676
55Bile secretion_Homo sapiens_hsa049761.43129502
56Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.42775182
57Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.41654621
58Lysosome_Homo sapiens_hsa041421.41256101
59Cysteine and methionine metabolism_Homo sapiens_hsa002701.41012910
60Sulfur relay system_Homo sapiens_hsa041221.39296317
61Hematopoietic cell lineage_Homo sapiens_hsa046401.38850566
62Vitamin digestion and absorption_Homo sapiens_hsa049771.38531712
63Measles_Homo sapiens_hsa051621.37367814
64Herpes simplex infection_Homo sapiens_hsa051681.37082814
65Starch and sucrose metabolism_Homo sapiens_hsa005001.35865729
66NOD-like receptor signaling pathway_Homo sapiens_hsa046211.33989480
67Biosynthesis of amino acids_Homo sapiens_hsa012301.31685298
68TNF signaling pathway_Homo sapiens_hsa046681.31144814
69Phenylalanine metabolism_Homo sapiens_hsa003601.30393431
70ABC transporters_Homo sapiens_hsa020101.29603811
71Carbon metabolism_Homo sapiens_hsa012001.29303955
72T cell receptor signaling pathway_Homo sapiens_hsa046601.29234811
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.25792605
74One carbon pool by folate_Homo sapiens_hsa006701.24979010
75Viral myocarditis_Homo sapiens_hsa054161.22142591
76Arginine and proline metabolism_Homo sapiens_hsa003301.20688451
77Tyrosine metabolism_Homo sapiens_hsa003501.18688734
78Fatty acid elongation_Homo sapiens_hsa000621.18195019
79* Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.17142980
80Maturity onset diabetes of the young_Homo sapiens_hsa049501.17101427
81Platelet activation_Homo sapiens_hsa046111.14216576
82Chemokine signaling pathway_Homo sapiens_hsa040621.13468537
83Chronic myeloid leukemia_Homo sapiens_hsa052201.12541063
84Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.12320097
85Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.10862270
86Malaria_Homo sapiens_hsa051441.10187327
87VEGF signaling pathway_Homo sapiens_hsa043701.10011631
88Non-small cell lung cancer_Homo sapiens_hsa052231.07556093
89Hepatitis B_Homo sapiens_hsa051611.06525021
90Jak-STAT signaling pathway_Homo sapiens_hsa046301.04991535
91Leukocyte transendothelial migration_Homo sapiens_hsa046701.00838323
92Steroid biosynthesis_Homo sapiens_hsa001001.00395113
93Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.00036473
94Glutathione metabolism_Homo sapiens_hsa004800.98816465
95Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.95765508
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.92282067
97Apoptosis_Homo sapiens_hsa042100.91113554
98Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.91013241
99Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.90971347
100Pancreatic cancer_Homo sapiens_hsa052120.89407039
101Pertussis_Homo sapiens_hsa051330.89389947
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87487042
103AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86003238
104African trypanosomiasis_Homo sapiens_hsa051430.85721877
105Pentose phosphate pathway_Homo sapiens_hsa000300.85336719
106Lysine degradation_Homo sapiens_hsa003100.85040078
107Notch signaling pathway_Homo sapiens_hsa043300.83717667
108Prolactin signaling pathway_Homo sapiens_hsa049170.81740345
109Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.79372543
110Rheumatoid arthritis_Homo sapiens_hsa053230.79076187
111Choline metabolism in cancer_Homo sapiens_hsa052310.78210455
112Phospholipase D signaling pathway_Homo sapiens_hsa040720.76018935
113Legionellosis_Homo sapiens_hsa051340.74956242
114Phagosome_Homo sapiens_hsa041450.74136297
115Glycerolipid metabolism_Homo sapiens_hsa005610.73226393
116mTOR signaling pathway_Homo sapiens_hsa041500.72909830
117Inositol phosphate metabolism_Homo sapiens_hsa005620.70875855
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.69178486
119Neurotrophin signaling pathway_Homo sapiens_hsa047220.68339551
120Epstein-Barr virus infection_Homo sapiens_hsa051690.64602097
121Shigellosis_Homo sapiens_hsa051310.61351985
122Bladder cancer_Homo sapiens_hsa052190.60318172
123Galactose metabolism_Homo sapiens_hsa000520.60257213
124Sphingolipid metabolism_Homo sapiens_hsa006000.58536878
125* Metabolic pathways_Homo sapiens_hsa011000.57748347
126GnRH signaling pathway_Homo sapiens_hsa049120.56941100
127HTLV-I infection_Homo sapiens_hsa051660.56215862
128Viral carcinogenesis_Homo sapiens_hsa052030.56144718
129Vitamin B6 metabolism_Homo sapiens_hsa007500.52565447
130Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52554768
131Endocytosis_Homo sapiens_hsa041440.52251044
132Fructose and mannose metabolism_Homo sapiens_hsa000510.52120331
133Fatty acid biosynthesis_Homo sapiens_hsa000610.51107334
134Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50244987
135Amoebiasis_Homo sapiens_hsa051460.49683105
136Endometrial cancer_Homo sapiens_hsa052130.48611599
137Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48438264
138Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47647537
139HIF-1 signaling pathway_Homo sapiens_hsa040660.47177250
140Salmonella infection_Homo sapiens_hsa051320.46272620
141FoxO signaling pathway_Homo sapiens_hsa040680.43839232
142Renal cell carcinoma_Homo sapiens_hsa052110.41558198
143Estrogen signaling pathway_Homo sapiens_hsa049150.39658511
144SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38817458
145Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37214885
146ErbB signaling pathway_Homo sapiens_hsa040120.35739666
147Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.27534199
148alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.23928822
149Insulin resistance_Homo sapiens_hsa049310.19745633
150Adipocytokine signaling pathway_Homo sapiens_hsa049200.17123649
151Renin-angiotensin system_Homo sapiens_hsa046140.15779123
152Linoleic acid metabolism_Homo sapiens_hsa005910.15319959
153Mineral absorption_Homo sapiens_hsa049780.15220759
154Other glycan degradation_Homo sapiens_hsa005110.09919029
155Intestinal immune network for IgA production_Homo sapiens_hsa046720.09499546
156Pyrimidine metabolism_Homo sapiens_hsa002400.08964498
157Glycosaminoglycan degradation_Homo sapiens_hsa005310.07145043
158Primary immunodeficiency_Homo sapiens_hsa053400.06670616
159Glycerophospholipid metabolism_Homo sapiens_hsa005640.04728993
160Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.01364449
161Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.1352370
162Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512-0.1295156
163Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1282759
164NF-kappa B signaling pathway_Homo sapiens_hsa04064-0.1197672
165AMPK signaling pathway_Homo sapiens_hsa04152-0.1019748
166Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623-0.0962329
167Prion diseases_Homo sapiens_hsa05020-0.0918156
168Protein digestion and absorption_Homo sapiens_hsa04974-0.0881871
169Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0853899
170Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0767940
171Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970-0.0555284
172Hepatitis C_Homo sapiens_hsa05160-0.0503307
173RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.0493643
174Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.0480082
175Glucagon signaling pathway_Homo sapiens_hsa04922-0.0476245
176Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0424141

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