NAE1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)5.68300153
2DNA methylation involved in gamete generation (GO:0043046)4.92050257
3chromatin remodeling at centromere (GO:0031055)4.61571654
4CENP-A containing nucleosome assembly (GO:0034080)4.49067987
5DNA strand elongation involved in DNA replication (GO:0006271)4.22397398
6cullin deneddylation (GO:0010388)4.20657329
7protein deneddylation (GO:0000338)4.11227605
8DNA strand elongation (GO:0022616)4.01769372
9mitotic metaphase plate congression (GO:0007080)3.96862877
10protein localization to kinetochore (GO:0034501)3.89040154
11DNA replication-independent nucleosome organization (GO:0034724)3.87254991
12DNA replication-independent nucleosome assembly (GO:0006336)3.87254991
13* DNA replication checkpoint (GO:0000076)3.86924339
14kinetochore organization (GO:0051383)3.86520717
15IMP biosynthetic process (GO:0006188)3.83878383
16histone exchange (GO:0043486)3.83506728
177-methylguanosine mRNA capping (GO:0006370)3.83449651
18proteasome assembly (GO:0043248)3.79961305
197-methylguanosine RNA capping (GO:0009452)3.78502348
20RNA capping (GO:0036260)3.78502348
21regulation of meiosis I (GO:0060631)3.76599326
22meiotic chromosome segregation (GO:0045132)3.72449155
23DNA ligation (GO:0006266)3.72269072
24kinetochore assembly (GO:0051382)3.65274389
25attachment of spindle microtubules to kinetochore (GO:0008608)3.63754279
26nucleobase biosynthetic process (GO:0046112)3.62017062
27somatic hypermutation of immunoglobulin genes (GO:0016446)3.57485816
28somatic diversification of immune receptors via somatic mutation (GO:0002566)3.57485816
29metaphase plate congression (GO:0051310)3.56924984
30regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.56738605
31regulation of mitotic spindle checkpoint (GO:1903504)3.56738605
32ribosome assembly (GO:0042255)3.56242890
33male meiosis (GO:0007140)3.53679135
34DNA double-strand break processing (GO:0000729)3.50624687
35replication fork processing (GO:0031297)3.48379697
36nuclear pore organization (GO:0006999)3.46126645
37synaptonemal complex assembly (GO:0007130)3.44664483
38negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.44570693
39synapsis (GO:0007129)3.43418439
40IMP metabolic process (GO:0046040)3.42867196
41mitotic sister chromatid segregation (GO:0000070)3.40804724
42regulation of double-strand break repair via homologous recombination (GO:0010569)3.40006429
43positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.38881631
44regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.37941899
45mitotic sister chromatid cohesion (GO:0007064)3.37712969
46synaptonemal complex organization (GO:0070193)3.37022300
47DNA catabolic process, exonucleolytic (GO:0000738)3.35448996
48nucleotide-excision repair, DNA gap filling (GO:0006297)3.34860179
49anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.34461819
50double-strand break repair via nonhomologous end joining (GO:0006303)3.32587989
51non-recombinational repair (GO:0000726)3.32587989
52sister chromatid segregation (GO:0000819)3.30901497
53negative regulation of DNA recombination (GO:0045910)3.29428162
54maturation of 5.8S rRNA (GO:0000460)3.26363722
55DNA damage response, detection of DNA damage (GO:0042769)3.23679532
56meiotic nuclear division (GO:0007126)3.22690270
57DNA unwinding involved in DNA replication (GO:0006268)3.18683723
58L-serine metabolic process (GO:0006563)3.18286543
59nuclear pore complex assembly (GO:0051292)3.16297337
60regulation of centriole replication (GO:0046599)3.16177199
61regulation of chromosome segregation (GO:0051983)3.15900744
62protein localization to chromosome, centromeric region (GO:0071459)3.14844103
63negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.14006855
64telomere maintenance via telomere lengthening (GO:0010833)3.12435135
65establishment of chromosome localization (GO:0051303)3.12026265
66negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.11466349
67negative regulation of sister chromatid segregation (GO:0033046)3.11466349
68negative regulation of mitotic sister chromatid separation (GO:2000816)3.11466349
69negative regulation of mitotic sister chromatid segregation (GO:0033048)3.11466349
70exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.11343050
71spindle checkpoint (GO:0031577)3.10954612
72chromosome organization involved in meiosis (GO:0070192)3.08269185
73ATP-dependent chromatin remodeling (GO:0043044)3.07014454
74mitotic spindle checkpoint (GO:0071174)3.06754658
75positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.05614526
76transcription-coupled nucleotide-excision repair (GO:0006283)3.03886571
77nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.03160455
78maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.03024426
79regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.02975533
80negative regulation of ligase activity (GO:0051352)3.02682430
81negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.02682430
82negative regulation of chromosome segregation (GO:0051985)3.02112429
83establishment of viral latency (GO:0019043)3.01481651
84mitotic spindle assembly checkpoint (GO:0007094)3.00977838
85telomere maintenance via recombination (GO:0000722)3.00565561
86chromatin assembly or disassembly (GO:0006333)2.99905378
87spindle assembly checkpoint (GO:0071173)2.98723178
88DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.98206225
89signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.97751681
90signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.97751681
91signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.97751681
92microtubule depolymerization (GO:0007019)2.97115547
93intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.96321014
94signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.96321014
95histone mRNA metabolic process (GO:0008334)2.96238378
96establishment of integrated proviral latency (GO:0075713)2.95369403
97regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.94942903
98regulation of mitotic sister chromatid separation (GO:0010965)2.94283677
99regulation of mitotic sister chromatid segregation (GO:0033047)2.94283677
100regulation of sister chromatid segregation (GO:0033045)2.94283677
101mitotic nuclear envelope disassembly (GO:0007077)2.93142630
102regulation of mitotic metaphase/anaphase transition (GO:0030071)2.92549865
103regulation of cellular amino acid metabolic process (GO:0006521)2.91778954
104reciprocal DNA recombination (GO:0035825)2.91229997
105reciprocal meiotic recombination (GO:0007131)2.91229997
106postreplication repair (GO:0006301)2.90448765
107rRNA modification (GO:0000154)2.90073906
108resolution of meiotic recombination intermediates (GO:0000712)2.90009340
109DNA replication-dependent nucleosome organization (GO:0034723)2.89920232
110DNA replication-dependent nucleosome assembly (GO:0006335)2.89920232
111negative regulation of meiosis (GO:0045835)2.89847654
112DNA replication initiation (GO:0006270)2.89488783
113regulation of nuclear cell cycle DNA replication (GO:0033262)2.89473459
114signal transduction involved in DNA integrity checkpoint (GO:0072401)2.89463904
115signal transduction involved in DNA damage checkpoint (GO:0072422)2.89463904
116negative regulation of mitosis (GO:0045839)2.89147341
117spliceosomal snRNP assembly (GO:0000387)2.88796155
118deoxyribonucleotide biosynthetic process (GO:0009263)2.88379727
119RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.87968324
120tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.87968324
121transcription elongation from RNA polymerase I promoter (GO:0006362)2.87957641
122signal transduction involved in cell cycle checkpoint (GO:0072395)2.87894607
123positive regulation of ligase activity (GO:0051351)2.87809170
124protein-cofactor linkage (GO:0018065)2.87529341
125mitotic recombination (GO:0006312)2.86688695
126establishment of protein localization to mitochondrial membrane (GO:0090151)2.86198438
127telomere maintenance via semi-conservative replication (GO:0032201)2.83373100
128DNA strand renaturation (GO:0000733)2.83214166
129regulation of helicase activity (GO:0051095)2.82979088
130purine nucleobase biosynthetic process (GO:0009113)2.82213685
131regulation of DNA endoreduplication (GO:0032875)2.81824458
132sister chromatid cohesion (GO:0007062)2.80645102
133RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.80613810
134rRNA methylation (GO:0031167)2.79820906
135histone H2A acetylation (GO:0043968)2.78821026
136response to X-ray (GO:0010165)2.78740216
137DNA synthesis involved in DNA repair (GO:0000731)2.78408622
138intra-S DNA damage checkpoint (GO:0031573)2.77263727
139negative regulation of DNA-dependent DNA replication (GO:2000104)2.77085664
140termination of RNA polymerase III transcription (GO:0006386)2.76150101
141transcription elongation from RNA polymerase III promoter (GO:0006385)2.76150101
142somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.75749952
143isotype switching (GO:0045190)2.75749952
144termination of RNA polymerase I transcription (GO:0006363)2.73654391
145deoxyribose phosphate biosynthetic process (GO:0046385)2.72725464
1462-deoxyribonucleotide biosynthetic process (GO:0009265)2.72725464

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.72917930
2RBPJ_22232070_ChIP-Seq_NCS_Mouse3.56016854
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.47112969
4E2F4_17652178_ChIP-ChIP_JURKAT_Human2.96161636
5GABP_17652178_ChIP-ChIP_JURKAT_Human2.92565672
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.84347616
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.61368805
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.57918045
9FUS_26573619_Chip-Seq_HEK293_Human2.42674294
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.35464593
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.35394157
12* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.33312247
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.27042187
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.25366338
15* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.25047072
16ELK1_19687146_ChIP-ChIP_HELA_Human2.18478203
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.13028432
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.05418783
19POU3F2_20337985_ChIP-ChIP_501MEL_Human2.05017760
20YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.99382977
21EWS_26573619_Chip-Seq_HEK293_Human1.98103414
22ETS1_20019798_ChIP-Seq_JURKAT_Human1.97352875
23PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.96010332
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.91732870
25VDR_22108803_ChIP-Seq_LS180_Human1.90653467
26ZFP57_27257070_Chip-Seq_ESCs_Mouse1.86520556
27FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.85645000
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.84411477
29VDR_23849224_ChIP-Seq_CD4+_Human1.84179588
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.83330108
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.79913862
32EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.78956458
33MYC_19030024_ChIP-ChIP_MESCs_Mouse1.78754178
34ZNF274_21170338_ChIP-Seq_K562_Hela1.77352698
35NELFA_20434984_ChIP-Seq_ESCs_Mouse1.77259977
36AR_21909140_ChIP-Seq_LNCAP_Human1.69949603
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.67924925
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62048158
39MYC_19079543_ChIP-ChIP_MESCs_Mouse1.61373839
40TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.61172952
41CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.60678034
42GBX2_23144817_ChIP-Seq_PC3_Human1.58828407
43GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.57787208
44DCP1A_22483619_ChIP-Seq_HELA_Human1.57775223
45PADI4_21655091_ChIP-ChIP_MCF-7_Human1.56141816
46TAF15_26573619_Chip-Seq_HEK293_Human1.56068474
47RNF2_27304074_Chip-Seq_NSC_Mouse1.52460841
48FOXP3_21729870_ChIP-Seq_TREG_Human1.52374093
49BMI1_23680149_ChIP-Seq_NPCS_Mouse1.50196671
50POU5F1_16153702_ChIP-ChIP_HESCs_Human1.48799573
51TP63_19390658_ChIP-ChIP_HaCaT_Human1.47500524
52SRF_21415370_ChIP-Seq_HL-1_Mouse1.46652794
53MYC_18358816_ChIP-ChIP_MESCs_Mouse1.45618896
54MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.45397354
55E2F1_18555785_ChIP-Seq_MESCs_Mouse1.40914280
56NANOG_16153702_ChIP-ChIP_HESCs_Human1.40894261
57P300_19829295_ChIP-Seq_ESCs_Human1.40673721
58THAP11_20581084_ChIP-Seq_MESCs_Mouse1.38758970
59MYCN_18555785_ChIP-Seq_MESCs_Mouse1.38101559
60TTF2_22483619_ChIP-Seq_HELA_Human1.33232681
61E2F1_21310950_ChIP-Seq_MCF-7_Human1.30966990
62TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30481324
63ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.28577370
64FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.27994490
65SOX2_16153702_ChIP-ChIP_HESCs_Human1.27194190
66SMAD_19615063_ChIP-ChIP_OVARY_Human1.27082426
67ELF1_17652178_ChIP-ChIP_JURKAT_Human1.26644977
68ZFX_18555785_ChIP-Seq_MESCs_Mouse1.26331789
69CTBP2_25329375_ChIP-Seq_LNCAP_Human1.22307292
70PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.22187125
71FOXM1_23109430_ChIP-Seq_U2OS_Human1.21809933
72MYC_18940864_ChIP-ChIP_HL60_Human1.20928283
73HOXB4_20404135_ChIP-ChIP_EML_Mouse1.17799053
74GABP_19822575_ChIP-Seq_HepG2_Human1.17556641
75NFE2_27457419_Chip-Seq_LIVER_Mouse1.16348873
76SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.15781595
77SOX2_18555785_ChIP-Seq_MESCs_Mouse1.15234847
78NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.15051388
79SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14575939
80YY1_21170310_ChIP-Seq_MESCs_Mouse1.14436755
81* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14304909
82CBX2_27304074_Chip-Seq_ESCs_Mouse1.09927680
83HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.09064292
84NANOG_18555785_Chip-Seq_ESCs_Mouse1.09028390
85POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.08656741
86ER_23166858_ChIP-Seq_MCF-7_Human1.07868283
87ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06224146
88IGF1R_20145208_ChIP-Seq_DFB_Human1.06148507
89NANOG_18555785_ChIP-Seq_MESCs_Mouse1.05337458
90PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.05178069
91RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04982691
92TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04247512
93E2F1_18555785_Chip-Seq_ESCs_Mouse1.03834022
94EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03075612
95POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02992899
96NOTCH1_21737748_ChIP-Seq_TLL_Human1.02958438
97STAT3_18555785_Chip-Seq_ESCs_Mouse1.02950395
98IRF1_19129219_ChIP-ChIP_H3396_Human1.02556376
99XRN2_22483619_ChIP-Seq_HELA_Human1.02515486
100PCGF2_27294783_Chip-Seq_NPCs_Mouse1.01708668
101SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.00805237
102CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.99048381
103CTBP1_25329375_ChIP-Seq_LNCAP_Human0.98381108
104SUZ12_18555785_Chip-Seq_ESCs_Mouse0.97921767
105MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96826381
106P53_22387025_ChIP-Seq_ESCs_Mouse0.96730672
107NMYC_18555785_Chip-Seq_ESCs_Mouse0.96473436
108NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.95305724
109EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.95095110
110EZH2_27294783_Chip-Seq_NPCs_Mouse0.94673576
111KDM5A_27292631_Chip-Seq_BREAST_Human0.85900836
112SOX17_20123909_ChIP-Seq_XEN_Mouse0.85213437
113MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.84544576
114CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.83228806
115GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.82675141
116HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.80559770
117CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.75792480
118ERG_20887958_ChIP-Seq_HPC-7_Mouse0.74528978
119NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.73229020
120CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.72218765
121EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.71960216
122KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.69477892
123KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.69477892

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation5.25126605
2MP0008057_abnormal_DNA_replication3.22728488
3MP0003693_abnormal_embryo_hatching3.22664177
4MP0008058_abnormal_DNA_repair3.22163624
5MP0010094_abnormal_chromosome_stability3.21006415
6MP0004957_abnormal_blastocyst_morpholog2.71432708
7MP0003123_paternal_imprinting2.69425760
8MP0006292_abnormal_olfactory_placode2.64022036
9MP0003787_abnormal_imprinting2.63944442
10MP0003121_genomic_imprinting2.48446228
11MP0009697_abnormal_copulation2.45837886
12MP0003077_abnormal_cell_cycle2.23356232
13MP0003786_premature_aging2.22623216
14MP0001529_abnormal_vocalization2.18704817
15MP0001188_hyperpigmentation2.15805093
16MP0003111_abnormal_nucleus_morphology2.12945000
17MP0008932_abnormal_embryonic_tissue2.07592287
18MP0002736_abnormal_nociception_after2.06472515
19MP0002210_abnormal_sex_determination2.01952829
20MP0002735_abnormal_chemical_nociception1.99215631
21MP0008007_abnormal_cellular_replicative1.96132207
22MP0001293_anophthalmia1.93235073
23MP0003880_abnormal_central_pattern1.92472846
24MP0001968_abnormal_touch/_nociception1.90475783
25MP0003718_maternal_effect1.89123058
26MP0003890_abnormal_embryonic-extraembry1.70878878
27MP0003122_maternal_imprinting1.69862202
28MP0003567_abnormal_fetal_cardiomyocyte1.69232386
29MP0002160_abnormal_reproductive_system1.67908701
30MP0001929_abnormal_gametogenesis1.65211119
31MP0005171_absent_coat_pigmentation1.58525974
32MP0001145_abnormal_male_reproductive1.48644372
33MP0000653_abnormal_sex_gland1.48519711
34MP0006276_abnormal_autonomic_nervous1.48444165
35MP0002163_abnormal_gland_morphology1.48134784
36MP0006072_abnormal_retinal_apoptosis1.41043120
37MP0002102_abnormal_ear_morphology1.38974365
38MP0005380_embryogenesis_phenotype1.33164913
39MP0001672_abnormal_embryogenesis/_devel1.33164913
40MP0003698_abnormal_male_reproductive1.30672942
41MP0001984_abnormal_olfaction1.26741998
42MP0008789_abnormal_olfactory_epithelium1.25627902
43MP0003315_abnormal_perineum_morphology1.25474833
44MP0008995_early_reproductive_senescence1.24126527
45MP0004147_increased_porphyrin_level1.22610650
46MP0003941_abnormal_skin_development1.22174294
47MP0000566_synostosis1.21985948
48MP0002734_abnormal_mechanical_nocicepti1.21691057
49MP0009672_abnormal_birth_weight1.19998104
50MP0006036_abnormal_mitochondrial_physio1.19743490
51MP0003186_abnormal_redox_activity1.18467914
52MP0001119_abnormal_female_reproductive1.18437337
53MP0009046_muscle_twitch1.15139599
54MP0005646_abnormal_pituitary_gland1.12662037
55MP0008260_abnormal_autophagy1.11567321
56MP0005389_reproductive_system_phenotype1.10836831
57MP0001177_atelectasis1.10794099
58MP0010386_abnormal_urinary_bladder1.10387478
59MP0005499_abnormal_olfactory_system1.08997398
60MP0005394_taste/olfaction_phenotype1.08997398
61MP0002184_abnormal_innervation1.07948523
62MP0001905_abnormal_dopamine_level1.05596434
63MP0001986_abnormal_taste_sensitivity1.04771780
64MP0002080_prenatal_lethality1.03979149
65MP0009745_abnormal_behavioral_response1.03651518
66MP0000372_irregular_coat_pigmentation1.03271676
67MP0000350_abnormal_cell_proliferation1.02961757
68MP0003984_embryonic_growth_retardation1.02851705
69MP0002088_abnormal_embryonic_growth/wei1.01348483
70MP0002876_abnormal_thyroid_physiology1.00656191
71MP0004197_abnormal_fetal_growth/weight/1.00519459
72MP0003937_abnormal_limbs/digits/tail_de0.99582758
73MP0000647_abnormal_sebaceous_gland0.97274265
74MP0003806_abnormal_nucleotide_metabolis0.97044255
75MP0005503_abnormal_tendon_morphology0.96882587
76MP0002572_abnormal_emotion/affect_behav0.96144037
77MP0003136_yellow_coat_color0.95536163
78MP0002067_abnormal_sensory_capabilities0.95452943
79MP0005075_abnormal_melanosome_morpholog0.95449026
80MP0000358_abnormal_cell_content/0.94287157
81MP0002638_abnormal_pupillary_reflex0.94057309
82MP0002938_white_spotting0.93807954
83MP0002277_abnormal_respiratory_mucosa0.92912573
84MP0002697_abnormal_eye_size0.92886969
85MP0002272_abnormal_nervous_system0.92508978
86MP0002009_preneoplasia0.92495648
87MP0005551_abnormal_eye_electrophysiolog0.91102774
88MP0002234_abnormal_pharynx_morphology0.91098317
89MP0000631_abnormal_neuroendocrine_gland0.90888668
90MP0004133_heterotaxia0.89707374
91MP0003635_abnormal_synaptic_transmissio0.88948143
92MP0002751_abnormal_autonomic_nervous0.88843142
93MP0009703_decreased_birth_body0.87780514
94MP0002090_abnormal_vision0.87476823
95MP0005253_abnormal_eye_physiology0.86257063
96MP0002111_abnormal_tail_morphology0.86147667
97MP0002063_abnormal_learning/memory/cond0.85570562
98MP0001730_embryonic_growth_arrest0.85444974
99MP0010307_abnormal_tumor_latency0.85117178
100MP0000778_abnormal_nervous_system0.83832126
101MP0005391_vision/eye_phenotype0.83535787
102MP0000313_abnormal_cell_death0.83498880
103MP0002161_abnormal_fertility/fecundity0.82939795
104MP0005084_abnormal_gallbladder_morpholo0.80321188
105MP0010030_abnormal_orbit_morphology0.79945180
106MP0003861_abnormal_nervous_system0.79786638
107MP0002837_dystrophic_cardiac_calcinosis0.79315976
108MP0006035_abnormal_mitochondrial_morpho0.76450090
109MP0000516_abnormal_urinary_system0.76196315
110MP0005367_renal/urinary_system_phenotyp0.76196315
111MP0003011_delayed_dark_adaptation0.75573609
112MP0003119_abnormal_digestive_system0.75296856
113MP0001440_abnormal_grooming_behavior0.74770438
114MP0005645_abnormal_hypothalamus_physiol0.73925797
115MP0001485_abnormal_pinna_reflex0.73843778
116MP0004215_abnormal_myocardial_fiber0.73475599
117MP0010352_gastrointestinal_tract_polyps0.73359140
118MP0002085_abnormal_embryonic_tissue0.73062817
119MP0000049_abnormal_middle_ear0.72290233
120MP0002086_abnormal_extraembryonic_tissu0.71638334
121MP0003755_abnormal_palate_morphology0.70736554
122MP0005386_behavior/neurological_phenoty0.70356648
123MP0004924_abnormal_behavior0.70356648
124MP0002084_abnormal_developmental_patter0.69828785
125MP0001697_abnormal_embryo_size0.69686958
126MP0003221_abnormal_cardiomyocyte_apopto0.69460678
127MP0001324_abnormal_eye_pigmentation0.69038276
128MP0005187_abnormal_penis_morphology0.67073260
129MP0002233_abnormal_nose_morphology0.65079851
130MP0001919_abnormal_reproductive_system0.64493377
131MP0005379_endocrine/exocrine_gland_phen0.63719273
132MP0001299_abnormal_eye_distance/0.63120736
133MP0001764_abnormal_homeostasis0.62120913
134MP0004142_abnormal_muscle_tone0.60935517
135MP0002653_abnormal_ependyma_morphology0.59959846
136MP0001286_abnormal_eye_development0.59946385
137MP0003699_abnormal_female_reproductive0.59551776

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.65806997
2Abnormality of the labia minora (HP:0012880)4.15785525
3Abnormal hair whorl (HP:0010721)3.40787857
4Chromsome breakage (HP:0040012)3.26475639
5Acute necrotizing encephalopathy (HP:0006965)3.23478441
6Chromosomal breakage induced by crosslinking agents (HP:0003221)3.21421065
7Nephrogenic diabetes insipidus (HP:0009806)3.18480744
8Medial flaring of the eyebrow (HP:0010747)3.11829364
9Congenital primary aphakia (HP:0007707)3.11551249
10Gait imbalance (HP:0002141)3.10028573
11Abnormal mitochondria in muscle tissue (HP:0008316)2.91922579
12Breast hypoplasia (HP:0003187)2.86078146
13Abnormal spermatogenesis (HP:0008669)2.81125997
14Supernumerary spleens (HP:0009799)2.79479241
15Progressive macrocephaly (HP:0004481)2.77010421
16Hyperglycinemia (HP:0002154)2.71280199
17Increased hepatocellular lipid droplets (HP:0006565)2.67819753
18Poor coordination (HP:0002370)2.62466115
19Azoospermia (HP:0000027)2.61615867
20Pancreatic fibrosis (HP:0100732)2.56721604
21Abnormality of serum amino acid levels (HP:0003112)2.53590818
22Patellar aplasia (HP:0006443)2.52806722
23Hypothermia (HP:0002045)2.49036774
24Embryonal renal neoplasm (HP:0011794)2.44497608
25Mitochondrial inheritance (HP:0001427)2.43285199
26Nephroblastoma (Wilms tumor) (HP:0002667)2.43060863
27Meckel diverticulum (HP:0002245)2.41926803
28Abnormality of methionine metabolism (HP:0010901)2.40753027
29Cortical dysplasia (HP:0002539)2.40092252
30Ependymoma (HP:0002888)2.37341055
31Microvesicular hepatic steatosis (HP:0001414)2.35331143
32Abnormality of the preputium (HP:0100587)2.33309971
33Febrile seizures (HP:0002373)2.33287278
34Triphalangeal thumb (HP:0001199)2.32643908
35Increased CSF lactate (HP:0002490)2.31610939
36Papillary thyroid carcinoma (HP:0002895)2.31383357
37Focal motor seizures (HP:0011153)2.29809080
38Abnormal lung lobation (HP:0002101)2.29668313
39Pancreatic cysts (HP:0001737)2.29262820
40Genital tract atresia (HP:0001827)2.28624773
41Rhabdomyosarcoma (HP:0002859)2.28139826
42Aplasia/Hypoplasia of the patella (HP:0006498)2.27445129
43Abnormality of the ileum (HP:0001549)2.26357201
44Aplasia/Hypoplasia of the uvula (HP:0010293)2.25884089
45Abnormality of glycine metabolism (HP:0010895)2.24586334
46Abnormality of serine family amino acid metabolism (HP:0010894)2.24586334
47Methylmalonic acidemia (HP:0002912)2.23890859
48True hermaphroditism (HP:0010459)2.22528806
49Vaginal atresia (HP:0000148)2.21774020
50Oligodactyly (hands) (HP:0001180)2.20250935
51Reticulocytopenia (HP:0001896)2.17840223
52Hyperglycinuria (HP:0003108)2.15193552
53Absent radius (HP:0003974)2.15151768
54Cerebral edema (HP:0002181)2.14427848
55Abnormality of glycolysis (HP:0004366)2.13955532
56Increased serum pyruvate (HP:0003542)2.13955532
57Myelodysplasia (HP:0002863)2.12847763
58Glioma (HP:0009733)2.12370819
59Facial cleft (HP:0002006)2.12332032
60Aplasia involving forearm bones (HP:0009822)2.11385498
61Absent forearm bone (HP:0003953)2.11385498
62Acute encephalopathy (HP:0006846)2.10636565
63Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.10195488
64Abnormality of alanine metabolism (HP:0010916)2.10195488
65Hyperalaninemia (HP:0003348)2.10195488
66Abnormality of chromosome stability (HP:0003220)2.09711740
67Abnormality of the carotid arteries (HP:0005344)2.08829202
68Preaxial hand polydactyly (HP:0001177)2.08452523
69Abnormality of aspartate family amino acid metabolism (HP:0010899)2.06855351
70Small intestinal stenosis (HP:0012848)2.06014320
71Duodenal stenosis (HP:0100867)2.06014320
72Colon cancer (HP:0003003)2.02268428
73Clubbing of toes (HP:0100760)2.02154794
74Gonadotropin excess (HP:0000837)2.00243343
75Multiple enchondromatosis (HP:0005701)1.99493091
76Neoplasm of the colon (HP:0100273)1.98060624
77Increased serum lactate (HP:0002151)1.96230573
78Increased nuchal translucency (HP:0010880)1.93419670
79Lipid accumulation in hepatocytes (HP:0006561)1.92989409
80Capillary hemangiomas (HP:0005306)1.92733158
81Hepatocellular necrosis (HP:0001404)1.92483746
82Type 2 muscle fiber atrophy (HP:0003554)1.90465774
83Aplasia/Hypoplasia of the tibia (HP:0005772)1.89230601
84Abnormality of the clitoris (HP:0000056)1.88737249
85Stenosis of the external auditory canal (HP:0000402)1.87463115
86Hypoplastic pelvis (HP:0008839)1.87327325
87Postnatal microcephaly (HP:0005484)1.85406342
88Optic disc pallor (HP:0000543)1.84760027
89Atonic seizures (HP:0010819)1.83954342
90Breast aplasia (HP:0100783)1.82219688
91Pendular nystagmus (HP:0012043)1.81089513
92Epileptic encephalopathy (HP:0200134)1.80556349
93Pancreatic islet-cell hyperplasia (HP:0004510)1.79669668
94Megaloblastic anemia (HP:0001889)1.79570251
95Postaxial foot polydactyly (HP:0001830)1.79475934
96Shawl scrotum (HP:0000049)1.79456918
97Abnormality of the astrocytes (HP:0100707)1.79153697
98Astrocytoma (HP:0009592)1.79153697
99Broad foot (HP:0001769)1.78805230
100Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.78177970
101Medulloblastoma (HP:0002885)1.77929176
102Median cleft lip (HP:0000161)1.77669142
103Optic nerve hypoplasia (HP:0000609)1.76496978
104Hepatic necrosis (HP:0002605)1.76238541
105Respiratory difficulties (HP:0002880)1.75901036
106Aplasia/Hypoplasia of the sternum (HP:0006714)1.75628554
107Methylmalonic aciduria (HP:0012120)1.74708815
108Renal Fanconi syndrome (HP:0001994)1.74655879
109Oligodactyly (HP:0012165)1.74568808
110Exercise intolerance (HP:0003546)1.74340385
111Intestinal atresia (HP:0011100)1.74208958
112Aplasia/Hypoplasia of the lens (HP:0008063)1.73311245
113Shoulder girdle muscle weakness (HP:0003547)1.72661939
114Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.72427269
115Bifid tongue (HP:0010297)1.72240689
116Aplasia/Hypoplasia of the tongue (HP:0010295)1.71905213
117Absent thumb (HP:0009777)1.71605813
118Lactic acidosis (HP:0003128)1.70851610
119Nephronophthisis (HP:0000090)1.70338450
120Volvulus (HP:0002580)1.69158567
121Aplasia/Hypoplasia of the breasts (HP:0010311)1.68714809
122Postaxial hand polydactyly (HP:0001162)1.68294590
123Neoplasm of the adrenal gland (HP:0100631)1.67937392
124Thyroid carcinoma (HP:0002890)1.66711049
125Horseshoe kidney (HP:0000085)1.66545411
126Sloping forehead (HP:0000340)1.66358150
127Abnormality of incisor morphology (HP:0011063)1.65135874
128Abnormality of the pons (HP:0007361)1.65058738
129Abnormality of the duodenum (HP:0002246)1.64704192
130Ectopic kidney (HP:0000086)1.64364003
131Biliary tract neoplasm (HP:0100574)1.64131688
132Wrist flexion contracture (HP:0001239)1.63656555
133Agnosia (HP:0010524)1.62898128
134Facial hemangioma (HP:0000329)1.62488076
135Aplasia cutis congenita (HP:0001057)1.62246490
136Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.62007487
137Decreased activity of mitochondrial respiratory chain (HP:0008972)1.62007487
138Septo-optic dysplasia (HP:0100842)1.61992787
139Abnormality of the anterior horn cell (HP:0006802)1.61299810
140Degeneration of anterior horn cells (HP:0002398)1.61299810
141Astigmatism (HP:0000483)1.61177302
142Hypoplasia of the pons (HP:0012110)1.61086986
143Short thumb (HP:0009778)1.60659283
144Aganglionic megacolon (HP:0002251)1.60437761
145Abnormality of midbrain morphology (HP:0002418)1.59808398
146Molar tooth sign on MRI (HP:0002419)1.59808398
147Ovarian neoplasm (HP:0100615)1.56846414
148Type I transferrin isoform profile (HP:0003642)1.56610019

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.00200508
2CDC73.26956525
3STK38L2.71126050
4ACVR1B2.68832613
5PLK42.63136570
6BUB12.58376870
7TRIM282.55929688
8SRPK12.44243973
9PLK22.16646131
10BMPR22.14850661
11MAP2K72.13539051
12EIF2AK12.09768168
13PLK32.06575985
14TSSK62.01042055
15VRK21.90640058
16MKNK11.76260938
17TNIK1.74049978
18ERBB31.72770744
19MAP3K121.70698697
20MAP3K41.69166149
21ZAK1.67104457
22AKT31.64029515
23WEE11.63022578
24MKNK21.60277480
25PLK11.58912525
26PBK1.57779693
27VRK11.52039450
28CCNB11.47122931
29SIK31.47006303
30NEK11.44873560
31PASK1.44217917
32EIF2AK31.41317797
33STK241.40307940
34TTK1.38976240
35NTRK31.38787297
36TAF11.37975107
37BCR1.37374951
38BRSK21.36524778
39CDK81.33407903
40MAP4K21.25327810
41CDK191.24486710
42CSNK1G11.18263286
43MAPK131.16074593
44STK161.15492195
45PRPF4B1.13875886
46MST41.10922024
47NUAK11.10853182
48NME11.08392450
49BMPR1B1.08317509
50ATR1.07233480
51FRK1.07025334
52PNCK1.07000131
53CHEK21.04103416
54BRAF1.00024341
55EIF2AK20.92464030
56BRSK10.89916117
57NEK60.85857849
58KSR10.83900590
59TXK0.83898589
60CSNK1A1L0.82046533
61DYRK20.81745903
62AURKB0.81388087
63OXSR10.78789190
64YES10.78469459
65AURKA0.77479488
66CHEK10.73180320
67TLK10.72308881
68FLT30.70867121
69GRK10.70855188
70STK30.70536241
71ATM0.70526530
72ALK0.70292622
73BCKDK0.68751827
74RPS6KA40.67618327
75MAP3K60.64721427
76DYRK30.63943198
77PDK30.61042756
78PDK40.61042756
79SGK20.60438394
80DAPK10.59916814
81CDK30.59153011
82CSNK2A10.58647497
83MELK0.58507623
84MINK10.57942392
85MAP2K40.53835901
86FGFR10.51863977
87CSNK2A20.50348610
88PRKCI0.50153238
89GRK70.49992549
90CDK10.49707888
91STK40.48797415
92CAMKK20.47246429
93CSNK1E0.46788471
94TIE10.46429446
95STK390.45911701
96BRD40.45255858
97CSNK1G30.43001210
98MARK10.42539390
99PINK10.41571712
100MYLK0.41147394
101ERBB40.39155326
102CDK70.39024999
103PRKCE0.38698251
104UHMK10.38670116
105ADRBK20.37760246
106CDK180.35873892
107CDK140.35814395
108CSNK1G20.34718706
109NEK20.34271534
110CDK20.34197605
111MAP3K80.34161480
112PRKCG0.34079401
113PDK20.33839489
114MARK30.33397241
115DYRK1A0.33300151
116EPHA40.32250028
117TGFBR10.31317938
118WNK40.31247046
119NLK0.31219010
120ADRBK10.30695989
121PRKDC0.30468239
122LATS10.29978052
123WNK30.29899789
124CDK150.29743322
125CAMK2A0.28348586
126LATS20.27864929
127CDK11A0.27795501
128TAOK20.27649191
129RPS6KB10.27141097
130INSRR0.23818857
131PAK40.23522166

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.37198177
2Mismatch repair_Homo sapiens_hsa034303.50836466
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.47369664
4RNA polymerase_Homo sapiens_hsa030203.24333259
5DNA replication_Homo sapiens_hsa030303.10543375
6Basal transcription factors_Homo sapiens_hsa030222.88054099
7Homologous recombination_Homo sapiens_hsa034402.74778845
8Nucleotide excision repair_Homo sapiens_hsa034202.62594943
9RNA transport_Homo sapiens_hsa030132.56305750
10Cell cycle_Homo sapiens_hsa041102.48960440
11Spliceosome_Homo sapiens_hsa030402.46707281
12Fanconi anemia pathway_Homo sapiens_hsa034602.34285314
13Non-homologous end-joining_Homo sapiens_hsa034502.27489226
14RNA degradation_Homo sapiens_hsa030182.18451452
15Oxidative phosphorylation_Homo sapiens_hsa001902.14441717
16Nicotine addiction_Homo sapiens_hsa050332.13226733
17Propanoate metabolism_Homo sapiens_hsa006402.01620253
18Pyrimidine metabolism_Homo sapiens_hsa002401.88561514
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.87276919
20Huntingtons disease_Homo sapiens_hsa050161.81518279
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.81199047
22Parkinsons disease_Homo sapiens_hsa050121.80218215
23mRNA surveillance pathway_Homo sapiens_hsa030151.74265104
24Collecting duct acid secretion_Homo sapiens_hsa049661.71023216
25Steroid biosynthesis_Homo sapiens_hsa001001.67832458
26Base excision repair_Homo sapiens_hsa034101.64498522
27Vitamin B6 metabolism_Homo sapiens_hsa007501.62518970
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.51658293
29Oocyte meiosis_Homo sapiens_hsa041141.51594033
30Ribosome_Homo sapiens_hsa030101.46808683
31Purine metabolism_Homo sapiens_hsa002301.45944879
32Phototransduction_Homo sapiens_hsa047441.43861894
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.41790431
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.38725538
35Selenocompound metabolism_Homo sapiens_hsa004501.38643080
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.37219673
37Synaptic vesicle cycle_Homo sapiens_hsa047211.33020847
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.26048466
39Protein export_Homo sapiens_hsa030601.21719112
40Epstein-Barr virus infection_Homo sapiens_hsa051691.16302335
41Fatty acid elongation_Homo sapiens_hsa000621.13786032
42Biosynthesis of amino acids_Homo sapiens_hsa012301.09202923
43Alzheimers disease_Homo sapiens_hsa050101.06275095
44Taste transduction_Homo sapiens_hsa047421.04343522
45Vibrio cholerae infection_Homo sapiens_hsa051101.02306335
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.02261440
47One carbon pool by folate_Homo sapiens_hsa006701.01426668
48Folate biosynthesis_Homo sapiens_hsa007900.99628952
49p53 signaling pathway_Homo sapiens_hsa041150.99068344
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97591783
51Carbon metabolism_Homo sapiens_hsa012000.95706210
52Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.94392560
53SNARE interactions in vesicular transport_Homo sapiens_hsa041300.89083718
54Regulation of autophagy_Homo sapiens_hsa041400.85015422
55Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.84959808
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83729169
57Serotonergic synapse_Homo sapiens_hsa047260.83691153
58Butanoate metabolism_Homo sapiens_hsa006500.81499693
59Glutathione metabolism_Homo sapiens_hsa004800.81262189
60Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.78602140
61Morphine addiction_Homo sapiens_hsa050320.76592256
62Amphetamine addiction_Homo sapiens_hsa050310.73452882
63Type I diabetes mellitus_Homo sapiens_hsa049400.69279531
64Long-term potentiation_Homo sapiens_hsa047200.68851127
65Olfactory transduction_Homo sapiens_hsa047400.67970215
66Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.67686984
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.67516564
68Fatty acid metabolism_Homo sapiens_hsa012120.67069006
69Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.66829248
70Rheumatoid arthritis_Homo sapiens_hsa053230.66266747
71Circadian rhythm_Homo sapiens_hsa047100.63606115
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.62574840
73Alcoholism_Homo sapiens_hsa050340.62326975
74Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.61500200
75Graft-versus-host disease_Homo sapiens_hsa053320.61180458
76Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59993432
77beta-Alanine metabolism_Homo sapiens_hsa004100.59892063
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56897627
79Peroxisome_Homo sapiens_hsa041460.56333735
80Herpes simplex infection_Homo sapiens_hsa051680.55907076
81Circadian entrainment_Homo sapiens_hsa047130.55278668
82Dopaminergic synapse_Homo sapiens_hsa047280.54661303
83Autoimmune thyroid disease_Homo sapiens_hsa053200.52975715
84Glutamatergic synapse_Homo sapiens_hsa047240.52648558
85Hippo signaling pathway_Homo sapiens_hsa043900.52332290
86Fatty acid degradation_Homo sapiens_hsa000710.50710822
87Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.50003024
88Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49821128
89N-Glycan biosynthesis_Homo sapiens_hsa005100.49436737
90Caffeine metabolism_Homo sapiens_hsa002320.48642349
91TGF-beta signaling pathway_Homo sapiens_hsa043500.48476849
92Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.46797532
93Cardiac muscle contraction_Homo sapiens_hsa042600.46334058
94Calcium signaling pathway_Homo sapiens_hsa040200.45975347
95GABAergic synapse_Homo sapiens_hsa047270.45850592
96Systemic lupus erythematosus_Homo sapiens_hsa053220.44672305
97Arginine and proline metabolism_Homo sapiens_hsa003300.44604150
98HTLV-I infection_Homo sapiens_hsa051660.41519562
99Primary bile acid biosynthesis_Homo sapiens_hsa001200.41393162
100Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41258967
101Drug metabolism - other enzymes_Homo sapiens_hsa009830.40456429
102Wnt signaling pathway_Homo sapiens_hsa043100.39307228
103Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39253344
104Long-term depression_Homo sapiens_hsa047300.38815820
105Hedgehog signaling pathway_Homo sapiens_hsa043400.37724182
106Sulfur relay system_Homo sapiens_hsa041220.35744455
107Tryptophan metabolism_Homo sapiens_hsa003800.34830955
108Basal cell carcinoma_Homo sapiens_hsa052170.34350547
109Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34325873
110Retinol metabolism_Homo sapiens_hsa008300.34127304
111Vitamin digestion and absorption_Homo sapiens_hsa049770.33960698
112Allograft rejection_Homo sapiens_hsa053300.33893037
113Viral carcinogenesis_Homo sapiens_hsa052030.33709327
114Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.32781452
115Arachidonic acid metabolism_Homo sapiens_hsa005900.31297936
116Phagosome_Homo sapiens_hsa041450.30433661
117Nitrogen metabolism_Homo sapiens_hsa009100.29834535
118Sulfur metabolism_Homo sapiens_hsa009200.26422598
119Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.26357276
120Fat digestion and absorption_Homo sapiens_hsa049750.24238578
121Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.23070425
122Lysine degradation_Homo sapiens_hsa003100.21568307
123Antigen processing and presentation_Homo sapiens_hsa046120.21302456
124Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.20631475
125Cysteine and methionine metabolism_Homo sapiens_hsa002700.20314262
126Renin secretion_Homo sapiens_hsa049240.19249944
127Ether lipid metabolism_Homo sapiens_hsa005650.18441291
128Colorectal cancer_Homo sapiens_hsa052100.18392957
129Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.17600319
130NOD-like receptor signaling pathway_Homo sapiens_hsa046210.17443909
131Pyruvate metabolism_Homo sapiens_hsa006200.16604843
132Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.16265114
133Oxytocin signaling pathway_Homo sapiens_hsa049210.16168620
134Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.15816988
135Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.15673370
136Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.15626286
137Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.15424106
138Metabolic pathways_Homo sapiens_hsa011000.15407845
139Cholinergic synapse_Homo sapiens_hsa047250.15240002
140Thyroid cancer_Homo sapiens_hsa052160.14833106
141Legionellosis_Homo sapiens_hsa051340.13034970
142Melanogenesis_Homo sapiens_hsa049160.12936488
143Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.11743668
144Melanoma_Homo sapiens_hsa052180.11284776
145Pathways in cancer_Homo sapiens_hsa052000.11222632
146Insulin secretion_Homo sapiens_hsa049110.10276132

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