NAF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)4.97480195
2nuclear pore complex assembly (GO:0051292)4.96503201
3nuclear pore organization (GO:0006999)4.95753124
4maturation of SSU-rRNA (GO:0030490)4.58200086
5response to pheromone (GO:0019236)4.41066458
6formation of translation preinitiation complex (GO:0001731)4.37709496
7regulation of gene silencing by RNA (GO:0060966)4.36779024
8regulation of posttranscriptional gene silencing (GO:0060147)4.36779024
9regulation of gene silencing by miRNA (GO:0060964)4.36779024
10DNA replication initiation (GO:0006270)4.26128194
11folic acid-containing compound biosynthetic process (GO:0009396)4.15489538
12pre-miRNA processing (GO:0031054)4.01965143
13protein localization to kinetochore (GO:0034501)4.00058107
14maturation of 5.8S rRNA (GO:0000460)3.98439659
15DNA double-strand break processing (GO:0000729)3.92872301
16viral transcription (GO:0019083)3.91381539
17IMP biosynthetic process (GO:0006188)3.89900738
18translational termination (GO:0006415)3.89480405
19ribosomal small subunit assembly (GO:0000028)3.87426538
20* ribosome biogenesis (GO:0042254)3.82426004
21nucleobase biosynthetic process (GO:0046112)3.81820191
22mitotic nuclear envelope disassembly (GO:0007077)3.81049854
23* ribonucleoprotein complex biogenesis (GO:0022613)3.79651926
24DNA replication-dependent nucleosome organization (GO:0034723)3.79167570
25DNA replication-dependent nucleosome assembly (GO:0006335)3.79167570
26heterochromatin organization (GO:0070828)3.78696190
27RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.76645735
28negative regulation of DNA-dependent DNA replication (GO:2000104)3.71016208
29DNA strand elongation involved in DNA replication (GO:0006271)3.69000210
30replication fork processing (GO:0031297)3.68700655
31ribosomal large subunit biogenesis (GO:0042273)3.67273386
32translational initiation (GO:0006413)3.63616210
33pore complex assembly (GO:0046931)3.63128718
34somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.61556989
35isotype switching (GO:0045190)3.61556989
36somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.61556989
37IMP metabolic process (GO:0046040)3.61505769
38ribosomal small subunit biogenesis (GO:0042274)3.56877439
39regulation of helicase activity (GO:0051095)3.56564640
40regulation of centriole replication (GO:0046599)3.54799943
41membrane disassembly (GO:0030397)3.54488442
42nuclear envelope disassembly (GO:0051081)3.54488442
43DNA duplex unwinding (GO:0032508)3.52009010
44positive regulation of chromosome segregation (GO:0051984)3.51648728
45DNA geometric change (GO:0032392)3.51096073
46nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.49552251
47mitochondrial RNA metabolic process (GO:0000959)3.48200789
48DNA strand elongation (GO:0022616)3.46664400
49protein localization to chromosome, centromeric region (GO:0071459)3.46589428
50regulation of translational fidelity (GO:0006450)3.45996838
51synapsis (GO:0007129)3.44564881
52* rRNA processing (GO:0006364)3.44193248
53DNA replication checkpoint (GO:0000076)3.43086646
54ribosome assembly (GO:0042255)3.41797358
55translational elongation (GO:0006414)3.40372185
56* rRNA metabolic process (GO:0016072)3.33905920
57mitotic metaphase plate congression (GO:0007080)3.33751991
58regulation of RNA export from nucleus (GO:0046831)3.33556788
59regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.31987152
60chromatin assembly (GO:0031497)3.31493395
61negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.31127878
62mitotic sister chromatid segregation (GO:0000070)3.31028021
63regulation of translational termination (GO:0006449)3.30833542
64regulation of centrosome duplication (GO:0010824)3.28913530
65purine nucleobase biosynthetic process (GO:0009113)3.28623748
66somatic recombination of immunoglobulin gene segments (GO:0016447)3.26872498
67somatic diversification of immunoglobulins (GO:0016445)3.24886739
68meiotic chromosome segregation (GO:0045132)3.24825377
69DNA catabolic process, exonucleolytic (GO:0000738)3.22730722
70mitotic sister chromatid cohesion (GO:0007064)3.19944703
71regulation of histone H3-K9 methylation (GO:0051570)3.19753812
72regulation of DNA endoreduplication (GO:0032875)3.19415871
73rRNA modification (GO:0000154)3.18681759
74* pseudouridine synthesis (GO:0001522)3.18481588
75telomere maintenance via semi-conservative replication (GO:0032201)3.16896900
76double-strand break repair via nonhomologous end joining (GO:0006303)3.16825028
77non-recombinational repair (GO:0000726)3.16825028
78protein K6-linked ubiquitination (GO:0085020)3.12339972
79negative regulation of histone methylation (GO:0031061)3.11045490
80negative regulation of mRNA processing (GO:0050686)3.08994534
81regulation of nuclear cell cycle DNA replication (GO:0033262)3.07126339
82negative regulation of RNA splicing (GO:0033119)3.06968133
83histone H4-K12 acetylation (GO:0043983)3.06687153
84exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.05922649
85sister chromatid segregation (GO:0000819)3.05744828
86DNA deamination (GO:0045006)3.05479632
87cellular protein complex disassembly (GO:0043624)3.05214502
88regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.04349815
89regulation of sister chromatid cohesion (GO:0007063)3.02603685
90chromatin remodeling at centromere (GO:0031055)3.02117538
91nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.01186258
92establishment of integrated proviral latency (GO:0075713)3.00314054
93intra-S DNA damage checkpoint (GO:0031573)2.97032575
94viral life cycle (GO:0019058)2.96987019
95histone exchange (GO:0043486)2.96700254
96positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.96604629
97positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.96604629
98positive regulation of mitotic sister chromatid separation (GO:1901970)2.96604629
99peptidyl-arginine omega-N-methylation (GO:0035247)2.94372011
100spliceosomal snRNP assembly (GO:0000387)2.94035664
101rRNA methylation (GO:0031167)2.93385769
102somatic diversification of immune receptors (GO:0002200)2.92554199
103somatic diversification of immune receptors via somatic mutation (GO:0002566)2.91616377
104somatic hypermutation of immunoglobulin genes (GO:0016446)2.91616377
105SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.91081520
106somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.90998891
107somatic cell DNA recombination (GO:0016444)2.90998891
108regulation of centrosome cycle (GO:0046605)2.90113274
109sister chromatid cohesion (GO:0007062)2.89744645
110double-strand break repair via homologous recombination (GO:0000724)2.89111517
111chromatin assembly or disassembly (GO:0006333)2.88857609
112maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.88768799
113protein complex disassembly (GO:0043241)2.88703427
114CENP-A containing nucleosome assembly (GO:0034080)2.88555819
115L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.88412442
116recombinational repair (GO:0000725)2.87680143
117transcription from mitochondrial promoter (GO:0006390)2.86764133
118metaphase plate congression (GO:0051310)2.85750982
119RNA stabilization (GO:0043489)2.85540535
120mRNA stabilization (GO:0048255)2.85540535
121protein targeting to ER (GO:0045047)2.84977201
122histone H2A acetylation (GO:0043968)2.84661260
123nuclear envelope organization (GO:0006998)2.84260799
124kinetochore organization (GO:0051383)2.84181945
125paraxial mesoderm development (GO:0048339)2.83878919
126positive regulation of histone H3-K4 methylation (GO:0051571)2.83700277
127regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.83590046
128regulation of mitotic spindle checkpoint (GO:1903504)2.83590046
129regulation of hippo signaling (GO:0035330)2.83421488
130nuclear-transcribed mRNA catabolic process (GO:0000956)2.83336421
131cotranslational protein targeting to membrane (GO:0006613)2.82942713
132telomere maintenance via recombination (GO:0000722)2.82931224
133nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.82852737
134DNA replication-independent nucleosome organization (GO:0034724)2.82243304
135DNA replication-independent nucleosome assembly (GO:0006336)2.82243304
136nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:0000288)2.81821139
137mitotic chromosome condensation (GO:0007076)2.81628362
138RNA splicing, via transesterification reactions (GO:0000375)2.81400351
139proteasome assembly (GO:0043248)2.81371599
140negative regulation of mRNA metabolic process (GO:1903312)2.79870547
141regulation of gene silencing (GO:0060968)2.79018071
142mRNA splicing, via spliceosome (GO:0000398)2.78104829
143RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.78104829
144mitotic recombination (GO:0006312)2.77874650
145dosage compensation (GO:0007549)2.77328924
146rRNA catabolic process (GO:0016075)2.77305281
147telomere maintenance via telomerase (GO:0007004)2.73975612
148telomere maintenance via telomere lengthening (GO:0010833)2.72471084
149DNA ligation (GO:0006266)2.71160241
150tRNA modification (GO:0006400)2.70866052
151N-terminal protein amino acid acetylation (GO:0006474)2.70837087
152nucleotide-excision repair, DNA gap filling (GO:0006297)2.70638258
153double-strand break repair (GO:0006302)2.68408643
154prenylation (GO:0097354)2.67824898
155protein prenylation (GO:0018342)2.67824898
156DNA topological change (GO:0006265)2.65894735
157response to X-ray (GO:0010165)2.64421509
158DNA recombination (GO:0006310)2.59481884
159establishment of protein localization to mitochondrial membrane (GO:0090151)2.59266642

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.66028977
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.53138823
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.03325518
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.63343354
5MYC_19079543_ChIP-ChIP_MESCs_Mouse3.38862774
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.22691098
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.96954551
8MYC_19030024_ChIP-ChIP_MESCs_Mouse2.89950385
9KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.74281340
10KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.74281340
11KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.74281340
12ZNF274_21170338_ChIP-Seq_K562_Hela2.63357644
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.55152218
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.47051992
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.29092392
16MYC_22102868_ChIP-Seq_BL_Human2.21517636
17SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.17907130
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.15120880
19XRN2_22483619_ChIP-Seq_HELA_Human2.13783267
20* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.10070562
21EWS_26573619_Chip-Seq_HEK293_Human2.10044177
22AR_21909140_ChIP-Seq_LNCAP_Human2.09906963
23FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.05492504
24EST1_17652178_ChIP-ChIP_JURKAT_Human2.02389996
25MYC_18940864_ChIP-ChIP_HL60_Human2.00131177
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.98001780
27VDR_22108803_ChIP-Seq_LS180_Human1.97585759
28* ETS1_20019798_ChIP-Seq_JURKAT_Human1.96926558
29POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.94689262
30MYCN_18555785_ChIP-Seq_MESCs_Mouse1.92556634
31MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.91631082
32CREB1_15753290_ChIP-ChIP_HEK293T_Human1.90105182
33FLI1_27457419_Chip-Seq_LIVER_Mouse1.87041484
34FUS_26573619_Chip-Seq_HEK293_Human1.84742259
35E2F1_21310950_ChIP-Seq_MCF-7_Human1.84316077
36HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.83442649
37MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.79784792
38TP63_19390658_ChIP-ChIP_HaCaT_Human1.79601616
39STAT3_1855785_ChIP-Seq_MESCs_Mouse1.78572182
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.77157339
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.75992943
42TTF2_22483619_ChIP-Seq_HELA_Human1.71784599
43GABP_17652178_ChIP-ChIP_JURKAT_Human1.68353792
44* VDR_23849224_ChIP-Seq_CD4+_Human1.68279287
45KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.66366409
46SRF_21415370_ChIP-Seq_HL-1_Mouse1.62473409
47E2F1_18555785_ChIP-Seq_MESCs_Mouse1.62392511
48TCF3_18692474_ChIP-Seq_MEFs_Mouse1.62349088
49ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.60053926
50JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.58820842
51NOTCH1_21737748_ChIP-Seq_TLL_Human1.58613592
52NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.58348845
53SALL1_21062744_ChIP-ChIP_HESCs_Human1.55843144
54POU3F2_20337985_ChIP-ChIP_501MEL_Human1.55143901
55POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.51427438
56DCP1A_22483619_ChIP-Seq_HELA_Human1.51178511
57SOX2_18555785_ChIP-Seq_MESCs_Mouse1.50189030
58ZFX_18555785_ChIP-Seq_MESCs_Mouse1.49399426
59ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.44965716
60FOXP3_21729870_ChIP-Seq_TREG_Human1.41651951
61E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.41649968
62SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.41585091
63KLF4_18555785_ChIP-Seq_MESCs_Mouse1.39653536
64GABP_19822575_ChIP-Seq_HepG2_Human1.38514774
65TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.38370507
66KDM5A_27292631_Chip-Seq_BREAST_Human1.36952643
67TCF3_18692474_ChIP-Seq_MESCs_Mouse1.35870955
68PCGF2_27294783_Chip-Seq_ESCs_Mouse1.35815843
69NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.35384759
70SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.34290737
71GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34144649
72NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.33210053
73ELK1_19687146_ChIP-ChIP_HELA_Human1.29791720
74PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29012631
75EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.27779818
76HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.26597651
77ELF1_17652178_ChIP-ChIP_JURKAT_Human1.26511735
78KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.24321330
79SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.22710330
80DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.22499428
81ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.21116558
82KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.21061610
83VDR_21846776_ChIP-Seq_THP-1_Human1.20623874
84YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18856843
85THAP11_20581084_ChIP-Seq_MESCs_Mouse1.17351513
86TAF15_26573619_Chip-Seq_HEK293_Human1.12474651
87CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.09245318
88CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.07881429
89TFEB_21752829_ChIP-Seq_HELA_Human1.07496481
90CIITA_25753668_ChIP-Seq_RAJI_Human1.07167828
91ER_23166858_ChIP-Seq_MCF-7_Human1.07135970
92NANOG_21062744_ChIP-ChIP_HESCs_Human1.06201094
93NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.05255389
94IGF1R_20145208_ChIP-Seq_DFB_Human1.05244953
95* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.04727910
96SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.04238041
97YY1_21170310_ChIP-Seq_MESCs_Mouse1.02689704
98NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.02193428
99E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02051347
100SOX2_18692474_ChIP-Seq_MEFs_Mouse1.01786117
101POU5F1_16153702_ChIP-ChIP_HESCs_Human1.01689501
102P300_19829295_ChIP-Seq_ESCs_Human1.01580312
103MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.01234234
104POU5F1_16518401_ChIP-PET_MESCs_Mouse1.01047275
105SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.99237488
106TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.99071454
107CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98974070
108* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.96515102
109SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96243768
110HOXB4_20404135_ChIP-ChIP_EML_Mouse0.95093628
111BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.94832326
112SOX2_18692474_ChIP-Seq_MESCs_Mouse0.94634728
113NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.94500793
114SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.93799341
115HIF1A_21447827_ChIP-Seq_MCF-7_Human0.92786880
116ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.92284917
117OCT4_18692474_ChIP-Seq_MEFs_Mouse0.91308774
118PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.91239057
119TP53_22573176_ChIP-Seq_HFKS_Human0.90233737
120CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.89424612
121ERG_20887958_ChIP-Seq_HPC-7_Mouse0.88872131
122NANOG_18692474_ChIP-Seq_MEFs_Mouse0.88796995
123DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.88540941
124PADI4_21655091_ChIP-ChIP_MCF-7_Human0.88395500
125EZH2_27294783_Chip-Seq_NPCs_Mouse0.87894341
126ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.87792985
127* ZFP57_27257070_Chip-Seq_ESCs_Mouse0.87788910
128ZNF263_19887448_ChIP-Seq_K562_Human0.87745098
129NANOG_16153702_ChIP-ChIP_HESCs_Human0.85821195
130SOX2_16153702_ChIP-ChIP_HESCs_Human0.84381962
131PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.83162392
132HOXB7_26014856_ChIP-Seq_BT474_Human0.81581334
133FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.80875255
134CBP_20019798_ChIP-Seq_JUKART_Human0.80621280
135IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.80621280
136RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.80037710
137PCGF2_27294783_Chip-Seq_NPCs_Mouse0.77757136
138BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.76860970
139RBPJ_22232070_ChIP-Seq_NCS_Mouse0.76132783
140ELF5_23300383_ChIP-Seq_T47D_Human0.75771003
141NFE2_27457419_Chip-Seq_LIVER_Mouse0.75656359
142MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.75025202
143SUZ12_27294783_Chip-Seq_NPCs_Mouse0.72524077
144CTBP2_25329375_ChIP-Seq_LNCAP_Human0.72443306
145GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.72231535

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.18396494
2MP0008057_abnormal_DNA_replication4.07887090
3MP0004957_abnormal_blastocyst_morpholog3.94963176
4MP0010094_abnormal_chromosome_stability3.82613598
5MP0003111_abnormal_nucleus_morphology3.56156581
6MP0003077_abnormal_cell_cycle3.22854101
7MP0010352_gastrointestinal_tract_polyps2.96232570
8MP0003646_muscle_fatigue2.66887914
9MP0002102_abnormal_ear_morphology2.61694883
10MP0008058_abnormal_DNA_repair2.52299088
11MP0002254_reproductive_system_inflammat2.48531496
12MP0001730_embryonic_growth_arrest2.38970039
13MP0008007_abnormal_cellular_replicative2.33889315
14MP0003123_paternal_imprinting2.31551743
15MP0008932_abnormal_embryonic_tissue2.28847825
16MP0000350_abnormal_cell_proliferation2.27963441
17MP0003718_maternal_effect2.25319549
18MP0000372_irregular_coat_pigmentation2.16493009
19MP0009697_abnormal_copulation2.14909511
20MP0001672_abnormal_embryogenesis/_devel2.09261170
21MP0005380_embryogenesis_phenotype2.09261170
22MP0002084_abnormal_developmental_patter2.02307343
23MP0010030_abnormal_orbit_morphology2.01699930
24MP0002396_abnormal_hematopoietic_system2.00402315
25MP0004197_abnormal_fetal_growth/weight/1.96295558
26MP0002085_abnormal_embryonic_tissue1.92815941
27MP0001697_abnormal_embryo_size1.90928823
28MP0005076_abnormal_cell_differentiation1.90369300
29MP0003984_embryonic_growth_retardation1.88073734
30MP0002160_abnormal_reproductive_system1.86540960
31MP0002088_abnormal_embryonic_growth/wei1.84692278
32MP0002086_abnormal_extraembryonic_tissu1.79900697
33MP0003890_abnormal_embryonic-extraembry1.79608243
34MP0001293_anophthalmia1.78160205
35MP0005646_abnormal_pituitary_gland1.71512039
36MP0003786_premature_aging1.71180317
37MP0010307_abnormal_tumor_latency1.70313619
38MP0008877_abnormal_DNA_methylation1.69674136
39MP0000490_abnormal_crypts_of1.62116526
40MP0002080_prenatal_lethality1.58237507
41MP0003567_abnormal_fetal_cardiomyocyte1.56140977
42MP0005410_abnormal_fertilization1.54920576
43MP0002877_abnormal_melanocyte_morpholog1.53551408
44MP0003705_abnormal_hypodermis_morpholog1.46911024
45MP0002837_dystrophic_cardiac_calcinosis1.46036474
46MP0005389_reproductive_system_phenotype1.43946234
47MP0004133_heterotaxia1.42047871
48MP0004808_abnormal_hematopoietic_stem1.41667775
49MP0003121_genomic_imprinting1.41494299
50MP0006072_abnormal_retinal_apoptosis1.36696388
51MP0003119_abnormal_digestive_system1.35460744
52MP0003937_abnormal_limbs/digits/tail_de1.30809954
53MP0005623_abnormal_meninges_morphology1.29932722
54MP0000313_abnormal_cell_death1.29902561
55MP0005645_abnormal_hypothalamus_physiol1.29556169
56MP0003950_abnormal_plasma_membrane1.29475093
57MP0002653_abnormal_ependyma_morphology1.23516352
58MP0009278_abnormal_bone_marrow1.22278797
59MP0001661_extended_life_span1.21585521
60MP0001545_abnormal_hematopoietic_system1.18442590
61MP0005397_hematopoietic_system_phenotyp1.18442590
62MP0000428_abnormal_craniofacial_morphol1.17561638
63MP0002234_abnormal_pharynx_morphology1.17552437
64MP0001764_abnormal_homeostasis1.17539030
65MP0010234_abnormal_vibrissa_follicle1.16234977
66MP0002009_preneoplasia1.16107882
67MP0003698_abnormal_male_reproductive1.13916779
68MP0002019_abnormal_tumor_incidence1.10375779
69MP0003878_abnormal_ear_physiology1.09302426
70MP0005377_hearing/vestibular/ear_phenot1.09302426
71MP0006292_abnormal_olfactory_placode1.08929592
72MP0005253_abnormal_eye_physiology1.08126319
73MP0006035_abnormal_mitochondrial_morpho1.07065479
74MP0002111_abnormal_tail_morphology1.06335043
75MP0001915_intracranial_hemorrhage1.05767708
76MP0002092_abnormal_eye_morphology1.04927309
77MP0000432_abnormal_head_morphology1.03063203
78MP0001919_abnormal_reproductive_system1.03018681
79MP0000537_abnormal_urethra_morphology1.02362609
80MP0003943_abnormal_hepatobiliary_system1.01709165
81MP0000631_abnormal_neuroendocrine_gland1.00998011
82MP0003941_abnormal_skin_development0.98916202
83MP0002163_abnormal_gland_morphology0.98878249
84MP0004264_abnormal_extraembryonic_tissu0.98780610
85MP0000427_abnormal_hair_cycle0.98531300
86MP0010678_abnormal_skin_adnexa0.98373016
87MP0009053_abnormal_anal_canal0.97625789
88MP0002938_white_spotting0.97597592
89MP0004233_abnormal_muscle_weight0.97286275
90MP0001286_abnormal_eye_development0.96742132
91MP0002210_abnormal_sex_determination0.96280618
92MP0000358_abnormal_cell_content/0.94913214
93MP0002697_abnormal_eye_size0.94188029
94MP0001849_ear_inflammation0.93110048
95MP0009333_abnormal_splenocyte_physiolog0.92921606
96MP0009703_decreased_birth_body0.92405185
97MP0001145_abnormal_male_reproductive0.90811755
98MP0003136_yellow_coat_color0.89179923
99MP0000703_abnormal_thymus_morphology0.88873301
100MP0005023_abnormal_wound_healing0.88724825
101MP0000733_abnormal_muscle_development0.88680218
102MP0003806_abnormal_nucleotide_metabolis0.88062419
103MP0003935_abnormal_craniofacial_develop0.87983095
104MP0008770_decreased_survivor_rate0.87534326
105MP0001119_abnormal_female_reproductive0.87323737
106MP0002925_abnormal_cardiovascular_devel0.86662806
107MP0009672_abnormal_birth_weight0.85614046
108MP0002249_abnormal_larynx_morphology0.84979022
109MP0002233_abnormal_nose_morphology0.83260102
110MP0005220_abnormal_exocrine_pancreas0.82703742
111MP0008775_abnormal_heart_ventricle0.79937715
112MP0001348_abnormal_lacrimal_gland0.79784387
113MP0003315_abnormal_perineum_morphology0.79236436
114MP0003566_abnormal_cell_adhesion0.77748340
115MP0003763_abnormal_thymus_physiology0.77499165
116MP0003861_abnormal_nervous_system0.77079585
117MP0004084_abnormal_cardiac_muscle0.76993136
118MP0002138_abnormal_hepatobiliary_system0.76041624
119MP0002282_abnormal_trachea_morphology0.75201573
120MP0002161_abnormal_fertility/fecundity0.74976264
121MP0000383_abnormal_hair_follicle0.73785888
122MP0002751_abnormal_autonomic_nervous0.73693253
123MP0005395_other_phenotype0.73289303
124MP0001929_abnormal_gametogenesis0.72194384
125MP0002114_abnormal_axial_skeleton0.72156374
126MP0000647_abnormal_sebaceous_gland0.71534859
127MP0000653_abnormal_sex_gland0.71305759
128MP0003755_abnormal_palate_morphology0.71013107
129MP0000516_abnormal_urinary_system0.70856842
130MP0005367_renal/urinary_system_phenotyp0.70856842
131MP0006036_abnormal_mitochondrial_physio0.70714317
132MP0000049_abnormal_middle_ear0.70433337
133MP0001529_abnormal_vocalization0.70246143
134MP0000477_abnormal_intestine_morphology0.69640987
135MP0002722_abnormal_immune_system0.68349169
136MP0002398_abnormal_bone_marrow0.68138288
137MP0003448_altered_tumor_morphology0.67159996
138MP0008995_early_reproductive_senescence0.66864686
139MP0009046_muscle_twitch0.66275893
140MP0003828_pulmonary_edema0.65833911
141MP0003936_abnormal_reproductive_system0.65797794
142MP0000858_altered_metastatic_potential0.65755787
143MP0002116_abnormal_craniofacial_bone0.65607862
144MP0005384_cellular_phenotype0.65394479
145MP0003699_abnormal_female_reproductive0.65366220
146MP0003283_abnormal_digestive_organ0.64890541
147MP0003938_abnormal_ear_development0.64865558
148MP0002006_tumorigenesis0.64760599
149MP0005391_vision/eye_phenotype0.64041505
150MP0008789_abnormal_olfactory_epithelium0.63872076
151MP0009250_abnormal_appendicular_skeleto0.63006833
152MP0005647_abnormal_sex_gland0.60904463
153MP0005266_abnormal_metabolism0.60351573

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)3.78969640
2Supernumerary spleens (HP:0009799)3.54029787
3Selective tooth agenesis (HP:0001592)3.52965687
4Abnormality of the labia minora (HP:0012880)3.42635533
5Colon cancer (HP:0003003)3.32943079
6Rib fusion (HP:0000902)3.25747594
7Reticulocytopenia (HP:0001896)3.23040464
8Duplicated collecting system (HP:0000081)3.20409241
9Methylmalonic acidemia (HP:0002912)3.17916388
10Missing ribs (HP:0000921)3.16103764
11Abnormality of cells of the erythroid lineage (HP:0012130)3.14916210
12Abnormality of homocysteine metabolism (HP:0010919)3.08015333
13Homocystinuria (HP:0002156)3.08015333
14Medulloblastoma (HP:0002885)3.07532131
15Breast hypoplasia (HP:0003187)3.02181882
16Absent radius (HP:0003974)2.98247569
17Birth length less than 3rd percentile (HP:0003561)2.95345464
18Abnormality of midbrain morphology (HP:0002418)2.86242361
19Molar tooth sign on MRI (HP:0002419)2.86242361
20Abnormality of abdominal situs (HP:0011620)2.85705766
21Abdominal situs inversus (HP:0003363)2.85705766
22Volvulus (HP:0002580)2.81743662
23Abnormality of the renal collecting system (HP:0004742)2.81283547
24Absent thumb (HP:0009777)2.80478661
25Pancreatic cysts (HP:0001737)2.79992419
26Aplasia involving forearm bones (HP:0009822)2.79307322
27Absent forearm bone (HP:0003953)2.79307322
28Rhabdomyosarcoma (HP:0002859)2.78369306
29Abnormal number of erythroid precursors (HP:0012131)2.75151758
30Abnormality of the astrocytes (HP:0100707)2.74774477
31Astrocytoma (HP:0009592)2.74774477
32Asplenia (HP:0001746)2.74675720
33Abnormality of the pons (HP:0007361)2.71506675
34Aplasia/hypoplasia of the humerus (HP:0006507)2.69292995
35Facial hemangioma (HP:0000329)2.68607384
36Chronic hepatic failure (HP:0100626)2.68510950
37Chromsome breakage (HP:0040012)2.68507421
38Proximal placement of thumb (HP:0009623)2.65308819
39Abnormal number of incisors (HP:0011064)2.64219425
40Deviation of the thumb (HP:0009603)2.63087843
41Pendular nystagmus (HP:0012043)2.59995203
42Chromosomal breakage induced by crosslinking agents (HP:0003221)2.58309210
43Neoplasm of the oral cavity (HP:0100649)2.57338599
44Abnormality of DNA repair (HP:0003254)2.56399137
45Hypoplasia of the pons (HP:0012110)2.55835168
46Short humerus (HP:0005792)2.55177111
47Aplasia/Hypoplasia of the spleen (HP:0010451)2.54832328
48Esophageal atresia (HP:0002032)2.52480331
49Impulsivity (HP:0100710)2.50540140
50Basal cell carcinoma (HP:0002671)2.50216338
5111 pairs of ribs (HP:0000878)2.42512850
52Neoplasm of striated muscle (HP:0009728)2.41126378
53Patellar aplasia (HP:0006443)2.41029930
54Pancreatic fibrosis (HP:0100732)2.40372593
55Atresia of the external auditory canal (HP:0000413)2.40242592
56Abnormality of chromosome stability (HP:0003220)2.34944971
57Methylmalonic aciduria (HP:0012120)2.34840363
58Abnormality of methionine metabolism (HP:0010901)2.34245386
59Glioma (HP:0009733)2.32210508
60Microvesicular hepatic steatosis (HP:0001414)2.31964481
61Sloping forehead (HP:0000340)2.31427954
62Meckel diverticulum (HP:0002245)2.26489109
63Agnosia (HP:0010524)2.23790839
64Abnormality of the anterior horn cell (HP:0006802)2.22977279
65Degeneration of anterior horn cells (HP:0002398)2.22977279
66Attenuation of retinal blood vessels (HP:0007843)2.22508144
67Abnormality of the ileum (HP:0001549)2.22082549
68Trismus (HP:0000211)2.21034778
69Myelodysplasia (HP:0002863)2.20910342
70Abnormality of the renal cortex (HP:0011035)2.20804335
71Aplasia/Hypoplasia of the patella (HP:0006498)2.20636446
72Aplasia/Hypoplasia of the uvula (HP:0010293)2.18911718
73Carpal bone hypoplasia (HP:0001498)2.18596746
74Squamous cell carcinoma (HP:0002860)2.18219026
75Multiple enchondromatosis (HP:0005701)2.17025211
76Supernumerary ribs (HP:0005815)2.16817801
77Clubbing of toes (HP:0100760)2.14116024
78Oral leukoplakia (HP:0002745)2.13226833
79Supernumerary bones of the axial skeleton (HP:0009144)2.12099951
80Abnormality of alanine metabolism (HP:0010916)2.09822770
81Hyperalaninemia (HP:0003348)2.09822770
82Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.09822770
83Glossoptosis (HP:0000162)2.09436754
84Rectal fistula (HP:0100590)2.09283163
85Rectovaginal fistula (HP:0000143)2.09283163
86Nephronophthisis (HP:0000090)2.08925977
87Hyperglycinemia (HP:0002154)2.07355665
88Septate vagina (HP:0001153)2.06894468
89Abnormality of the preputium (HP:0100587)2.06135231
90Abnormality of aspartate family amino acid metabolism (HP:0010899)2.05855473
91Abnormality of the carotid arteries (HP:0005344)2.05486194
92Increased nuchal translucency (HP:0010880)2.05259382
93Tubular atrophy (HP:0000092)2.01881236
94Aplastic anemia (HP:0001915)2.01019428
95Macrocytic anemia (HP:0001972)2.00783446
96Horseshoe kidney (HP:0000085)2.00645112
97Ectopic kidney (HP:0000086)1.99375036
98Abnormality of the duodenum (HP:0002246)1.98560085
99Prominent nose (HP:0000448)1.97441279
100Pallor (HP:0000980)1.97367287
101Small hand (HP:0200055)1.96518307
102Stomatitis (HP:0010280)1.95429342
103Fused cervical vertebrae (HP:0002949)1.94859783
104Abnormality of vitamin B metabolism (HP:0004340)1.93581163
105Urethral obstruction (HP:0000796)1.93452538
106Aplasia/Hypoplasia involving the musculature (HP:0001460)1.92445241
107Increased serum lactate (HP:0002151)1.92078428
108Abnormality of the vitamin B12 metabolism (HP:0004341)1.91830260
109Sparse lateral eyebrow (HP:0005338)1.91636091
110Rough bone trabeculation (HP:0100670)1.91351374
111Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.90918217
112Tracheoesophageal fistula (HP:0002575)1.90644874
113Progressive muscle weakness (HP:0003323)1.88940400
114Intestinal fistula (HP:0100819)1.87654685
115True hermaphroditism (HP:0010459)1.87098068
116Pancytopenia (HP:0001876)1.86649180
117Vertebral fusion (HP:0002948)1.86340263
118Vertebral clefting (HP:0008428)1.86009253
119Short thumb (HP:0009778)1.84345443
120Duodenal stenosis (HP:0100867)1.84296150
121Small intestinal stenosis (HP:0012848)1.84296150
122Stenosis of the external auditory canal (HP:0000402)1.84249061
123Sclerocornea (HP:0000647)1.83974226
124Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.82902929
125Vertebral hypoplasia (HP:0008417)1.82902929
126Overlapping toe (HP:0001845)1.81905440
127Gastrointestinal atresia (HP:0002589)1.81535679
128Skin tags (HP:0010609)1.81408487
129Hypoplasia of the radius (HP:0002984)1.81382326
130Preauricular skin tag (HP:0000384)1.81242999
131Neoplasm of the pancreas (HP:0002894)1.80325077
132Pseudobulbar signs (HP:0002200)1.80318696
133Abnormality of the renal medulla (HP:0100957)1.79658205
134Triphalangeal thumb (HP:0001199)1.79429717
135Premature graying of hair (HP:0002216)1.78981575
136Hemivertebrae (HP:0002937)1.78733163
137Abnormal biliary tract physiology (HP:0012439)1.77788696
138Bile duct proliferation (HP:0001408)1.77788696
139Pancreatic islet-cell hyperplasia (HP:0004510)1.77077422
140Preaxial hand polydactyly (HP:0001177)1.75624620
141Acute encephalopathy (HP:0006846)1.75383712
142Ulnar bowing (HP:0003031)1.75114398
143Acute necrotizing encephalopathy (HP:0006965)1.74881654
144Increased CSF lactate (HP:0002490)1.73836425
145Lipid accumulation in hepatocytes (HP:0006561)1.73385939
146Abnormality of the salivary glands (HP:0010286)1.72142944
147Biliary tract neoplasm (HP:0100574)1.71070173
148Prostate neoplasm (HP:0100787)1.70654496
149Broad thumb (HP:0011304)1.70620180
150Increased hepatocellular lipid droplets (HP:0006565)1.69930990
151Abnormality of serum amino acid levels (HP:0003112)1.69742447
152Gaze-evoked nystagmus (HP:0000640)1.69383377
153Tubulointerstitial nephritis (HP:0001970)1.69313131
154Renal cortical cysts (HP:0000803)1.69283781
155Long eyelashes (HP:0000527)1.68841347
156Fair hair (HP:0002286)1.68624019
157Abnormality of the antihelix (HP:0009738)1.68523131
158Spinal muscular atrophy (HP:0007269)1.68466874
159Abnormality of sulfur amino acid metabolism (HP:0004339)1.67867860
160High pitched voice (HP:0001620)1.67537399
161Oculomotor apraxia (HP:0000657)1.63737015
162Acute lymphatic leukemia (HP:0006721)1.63174439
163Hyperglycinuria (HP:0003108)1.61599057
164Neoplasm of the adrenal cortex (HP:0100641)1.61576437
165Ureteral duplication (HP:0000073)1.59902309
166Congenital stationary night blindness (HP:0007642)1.59787816
167Dry hair (HP:0011359)1.58536167
168Abnormality of the prostate (HP:0008775)1.57542493
169Abolished electroretinogram (ERG) (HP:0000550)1.57501476
170Postaxial foot polydactyly (HP:0001830)1.56664663

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.74246602
2CDC74.11293949
3WEE13.58094832
4FRK3.12201714
5BUB12.60918404
6BMPR1B2.56200691
7ZAK2.52757592
8NUAK12.52166634
9MAP4K22.51994720
10NEK22.48204655
11CDK72.21665064
12EEF2K2.20867351
13STK102.19761555
14TTK2.19433026
15MST42.06702200
16MKNK12.05389183
17MKNK22.01376653
18RPS6KB22.01002318
19WNK41.95221888
20ALK1.94045774
21TSSK61.84196801
22ICK1.83258629
23NME21.82873455
24EPHA21.82043896
25TYRO31.78847663
26STK391.77622509
27CDK41.77448690
28PASK1.77417131
29CHEK21.72912207
30TRIM281.72076151
31TAF11.69251561
32PLK11.68423265
33STK161.67675946
34VRK21.60282659
35PNCK1.54936857
36DYRK31.54722616
37PKN21.50853280
38TGFBR11.45391381
39BRD41.44395442
40CHEK11.44007674
41MAP3K81.44004607
42AURKB1.40882359
43SRPK11.40633306
44CDK61.37839070
45PLK31.37356638
46ATR1.36564814
47AKT31.36052509
48BRSK21.35298564
49LATS21.35148876
50MAP3K101.32956843
51TESK21.30777077
52STK31.29924077
53PLK21.23467825
54PIM11.20078915
55LRRK21.17773724
56CAMK1G1.16545846
57PAK41.15195101
58WNK31.11892003
59PBK1.10660244
60MAPKAPK31.10567661
61RPS6KA41.08694022
62MTOR1.07086657
63CDK21.05781624
64SCYL21.03818242
65AURKA1.02648001
66PLK41.02162432
67ATM1.01588013
68EIF2AK10.97409053
69VRK10.97405260
70GRK60.96450070
71ACVR1B0.95457171
72CLK10.93008210
73ERBB30.92846756
74GRK10.92510884
75NEK10.89226182
76CAMK1D0.87445164
77EIF2AK20.85389578
78PIM20.84972401
79DDR20.83845283
80TXK0.83597880
81CDK80.83375145
82LATS10.82372410
83MAPKAPK50.81774779
84PAK20.80270187
85TLK10.80265212
86STK38L0.78090777
87TNIK0.77884318
88CDK90.74786699
89MAP3K40.73640252
90CSNK1E0.72882167
91MELK0.72440497
92CSNK2A20.72247648
93TAOK30.72132849
94ADRBK20.71989698
95AKT20.71433017
96EIF2AK30.70872025
97OXSR10.67539741
98BMX0.67305342
99CDK10.66675100
100FGFR10.66455157
101PDGFRA0.65293159
102MAPK130.62931480
103BRAF0.62897472
104PAK10.61214584
105MAP2K70.59819985
106MAP4K10.59695576
107INSRR0.57894908
108MAP3K90.57803725
109CDK30.57202149
110OBSCN0.56714743
111FLT30.56555162
112TRPM70.55907627
113STK40.55734932
114PDK20.52508845
115TGFBR20.52441349
116MAP3K110.52080098
117NEK90.51774073
118CSNK1D0.51464424
119CSNK1G10.50188976
120BRSK10.48814705
121RPS6KA50.47688075
122CSNK2A10.47595403
123BLK0.46590658
124MAPK10.45901744
125NME10.45192243
126MAPK140.44654341
127MAP3K30.43480280
128PRKCI0.42624628
129PRKDC0.41833513
130RPS6KA10.41156131
131MAPK110.40840827
132BTK0.38636024
133PTK60.37860183
134CSK0.37683220
135IKBKB0.35896174
136RAF10.35698637
137PRKG20.34746044
138MAP2K20.34620272
139CHUK0.33690380
140MARK30.32421835
141MATK0.31760698
142GSK3A0.31712978
143MAPK100.30684978
144RPS6KB10.30607202
145MAP3K140.30336414
146AKT10.30039435

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.32710482
2DNA replication_Homo sapiens_hsa030304.19736087
3Mismatch repair_Homo sapiens_hsa034303.86141725
4RNA transport_Homo sapiens_hsa030133.47587609
5Spliceosome_Homo sapiens_hsa030403.44100010
6Ribosome_Homo sapiens_hsa030103.42804645
7One carbon pool by folate_Homo sapiens_hsa006702.87389278
8RNA polymerase_Homo sapiens_hsa030202.85284813
9Cell cycle_Homo sapiens_hsa041102.63453751
10Base excision repair_Homo sapiens_hsa034102.61040359
11Nucleotide excision repair_Homo sapiens_hsa034202.45531744
12Homologous recombination_Homo sapiens_hsa034402.42823612
13mRNA surveillance pathway_Homo sapiens_hsa030152.29293484
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.17252788
15RNA degradation_Homo sapiens_hsa030181.95837283
16Fanconi anemia pathway_Homo sapiens_hsa034601.93579687
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.88114369
18Basal transcription factors_Homo sapiens_hsa030221.86157907
19Pyrimidine metabolism_Homo sapiens_hsa002401.86001677
20Protein export_Homo sapiens_hsa030601.77518314
21p53 signaling pathway_Homo sapiens_hsa041151.67674744
22Non-homologous end-joining_Homo sapiens_hsa034501.61717273
23Propanoate metabolism_Homo sapiens_hsa006401.48484320
24Proteasome_Homo sapiens_hsa030501.36898418
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.30656038
26Basal cell carcinoma_Homo sapiens_hsa052171.26935401
27MicroRNAs in cancer_Homo sapiens_hsa052061.24333860
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.24032711
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.23754610
30Hippo signaling pathway_Homo sapiens_hsa043901.20104809
31Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.18903791
32Viral carcinogenesis_Homo sapiens_hsa052031.14218054
33Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.13213785
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.10617321
35TGF-beta signaling pathway_Homo sapiens_hsa043501.05439944
36HTLV-I infection_Homo sapiens_hsa051661.03635477
37Epstein-Barr virus infection_Homo sapiens_hsa051691.03547624
38Thyroid cancer_Homo sapiens_hsa052161.02976996
39Notch signaling pathway_Homo sapiens_hsa043300.99176766
40Small cell lung cancer_Homo sapiens_hsa052220.98287871
41Nitrogen metabolism_Homo sapiens_hsa009100.98258455
42Herpes simplex infection_Homo sapiens_hsa051680.97896332
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.96756862
44Antigen processing and presentation_Homo sapiens_hsa046120.96073691
45Transcriptional misregulation in cancer_Homo sapiens_hsa052020.94402226
46Purine metabolism_Homo sapiens_hsa002300.90736240
47Oocyte meiosis_Homo sapiens_hsa041140.89415500
48Sulfur relay system_Homo sapiens_hsa041220.89331498
49mTOR signaling pathway_Homo sapiens_hsa041500.88584897
50Colorectal cancer_Homo sapiens_hsa052100.86167626
51Acute myeloid leukemia_Homo sapiens_hsa052210.85893881
52Systemic lupus erythematosus_Homo sapiens_hsa053220.84502255
53Phototransduction_Homo sapiens_hsa047440.83744726
54Hedgehog signaling pathway_Homo sapiens_hsa043400.82985639
55Bladder cancer_Homo sapiens_hsa052190.81847523
56Ether lipid metabolism_Homo sapiens_hsa005650.81784738
57Linoleic acid metabolism_Homo sapiens_hsa005910.80492159
58Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79837262
59Adherens junction_Homo sapiens_hsa045200.79475568
60Chronic myeloid leukemia_Homo sapiens_hsa052200.77889039
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.77765193
62Cyanoamino acid metabolism_Homo sapiens_hsa004600.72832241
63Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71562897
64Vitamin B6 metabolism_Homo sapiens_hsa007500.70597603
65Wnt signaling pathway_Homo sapiens_hsa043100.70011590
66Biosynthesis of amino acids_Homo sapiens_hsa012300.69991974
67Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.69579074
68Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.69344718
69Pentose phosphate pathway_Homo sapiens_hsa000300.68226729
70Central carbon metabolism in cancer_Homo sapiens_hsa052300.67509363
71Pathways in cancer_Homo sapiens_hsa052000.67144481
72Huntingtons disease_Homo sapiens_hsa050160.66949975
73Steroid biosynthesis_Homo sapiens_hsa001000.65121806
74Butanoate metabolism_Homo sapiens_hsa006500.65053057
75Proteoglycans in cancer_Homo sapiens_hsa052050.60723804
76Cysteine and methionine metabolism_Homo sapiens_hsa002700.59243080
77Hepatitis B_Homo sapiens_hsa051610.56728775
78Apoptosis_Homo sapiens_hsa042100.55976777
79Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55898880
80Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55724314
81Oxidative phosphorylation_Homo sapiens_hsa001900.55490811
82Shigellosis_Homo sapiens_hsa051310.54455996
83Prostate cancer_Homo sapiens_hsa052150.52201939
84Pyruvate metabolism_Homo sapiens_hsa006200.51793468
85Olfactory transduction_Homo sapiens_hsa047400.51741389
86Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.49078052
87HIF-1 signaling pathway_Homo sapiens_hsa040660.48625666
88Metabolic pathways_Homo sapiens_hsa011000.47563219
89Legionellosis_Homo sapiens_hsa051340.47372649
90Asthma_Homo sapiens_hsa053100.47089671
91NF-kappa B signaling pathway_Homo sapiens_hsa040640.46254821
92Folate biosynthesis_Homo sapiens_hsa007900.45592838
93Tight junction_Homo sapiens_hsa045300.45158465
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44995157
95Caffeine metabolism_Homo sapiens_hsa002320.44294520
96Parkinsons disease_Homo sapiens_hsa050120.42194185
97Peroxisome_Homo sapiens_hsa041460.41956768
98Viral myocarditis_Homo sapiens_hsa054160.40455988
99Melanoma_Homo sapiens_hsa052180.39790687
100Vitamin digestion and absorption_Homo sapiens_hsa049770.39275514
101Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38937586
102Tryptophan metabolism_Homo sapiens_hsa003800.38903871
103PI3K-Akt signaling pathway_Homo sapiens_hsa041510.38693734
104Circadian rhythm_Homo sapiens_hsa047100.35908993
105Intestinal immune network for IgA production_Homo sapiens_hsa046720.35024095
106Measles_Homo sapiens_hsa051620.35014020
107Renal cell carcinoma_Homo sapiens_hsa052110.34171942
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33810489
109Non-small cell lung cancer_Homo sapiens_hsa052230.32019363
110Maturity onset diabetes of the young_Homo sapiens_hsa049500.31122430
111Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.30834999
112Selenocompound metabolism_Homo sapiens_hsa004500.30295700
113Focal adhesion_Homo sapiens_hsa045100.30081519
114Lysine degradation_Homo sapiens_hsa003100.29670898
115Pancreatic cancer_Homo sapiens_hsa052120.29601521
116Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29437833
117Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.28803655
118Primary immunodeficiency_Homo sapiens_hsa053400.28253763
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28031090
120Glutathione metabolism_Homo sapiens_hsa004800.27532461
121Fatty acid elongation_Homo sapiens_hsa000620.27397421
122Fatty acid biosynthesis_Homo sapiens_hsa000610.25982622
123B cell receptor signaling pathway_Homo sapiens_hsa046620.25703131
124AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.25239963
125Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.25050931
126Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.24949361
127Leukocyte transendothelial migration_Homo sapiens_hsa046700.24493874
128T cell receptor signaling pathway_Homo sapiens_hsa046600.23533844
129RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.22849854
130Taste transduction_Homo sapiens_hsa047420.21535839
131Endometrial cancer_Homo sapiens_hsa052130.21458025
132Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.20477088
133AMPK signaling pathway_Homo sapiens_hsa041520.20439808
134ECM-receptor interaction_Homo sapiens_hsa045120.20272765
135Alcoholism_Homo sapiens_hsa050340.20233093
136Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.20175650
137Regulation of autophagy_Homo sapiens_hsa041400.19716550
138Fatty acid metabolism_Homo sapiens_hsa012120.18366799
139Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.17847553
140NOD-like receptor signaling pathway_Homo sapiens_hsa046210.17768662
141Carbon metabolism_Homo sapiens_hsa012000.17630654
142Jak-STAT signaling pathway_Homo sapiens_hsa046300.17138165
143Arachidonic acid metabolism_Homo sapiens_hsa005900.16507423
144Dorso-ventral axis formation_Homo sapiens_hsa043200.16216646
145Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.14487422
146N-Glycan biosynthesis_Homo sapiens_hsa005100.13253913

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