NAGA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: NAGA encodes the lysosomal enzyme alpha-N-acetylgalactosaminidase, which cleaves alpha-N-acetylgalactosaminyl moieties from glycoconjugates. Mutations in NAGA have been identified as the cause of Schindler disease types I and II (type II also known as Kanzaki disease). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)6.57641824
2COPI coating of Golgi vesicle (GO:0048205)6.57641824
3signal peptide processing (GO:0006465)4.85915516
4maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.73223694
5detection of other organism (GO:0098543)4.49162733
6negative regulation of interleukin-12 production (GO:0032695)4.38765909
7detection of bacterium (GO:0016045)4.26792652
8immunoglobulin mediated immune response (GO:0016064)4.25235794
9protein retention in ER lumen (GO:0006621)4.19752681
10COPII vesicle coating (GO:0048208)4.11752963
11negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.03355155
12negative regulation of cell killing (GO:0031342)4.03355155
13antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.91767040
14antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.91767040
15cellular extravasation (GO:0045123)3.91615375
16endocrine pancreas development (GO:0031018)3.89057543
17detection of external biotic stimulus (GO:0098581)3.87662385
18retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.87457385
19regulation of mast cell degranulation (GO:0043304)3.84819102
20antigen processing and presentation of endogenous antigen (GO:0019883)3.82350968
21detection of molecule of bacterial origin (GO:0032490)3.79474441
22sequestering of metal ion (GO:0051238)3.69130773
23positive regulation by symbiont of host defense response (GO:0052509)3.63369740
24modulation by symbiont of host defense response (GO:0052031)3.63369740
25modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.63369740
26modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.63369740
27positive regulation by organism of defense response of other organism involved in symbiotic interact3.63369740
28modulation by symbiont of host immune response (GO:0052553)3.63369740
29regulation of myeloid leukocyte mediated immunity (GO:0002886)3.60412172
30regulation of leukocyte degranulation (GO:0043300)3.58511717
31peptide hormone processing (GO:0016486)3.57716216
32cellular response to thyroid hormone stimulus (GO:0097067)3.55925623
33activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.55161791
34production of molecular mediator involved in inflammatory response (GO:0002532)3.54262856
35positive regulation of mast cell activation (GO:0033005)3.53284302
36positive regulation of cellular amide metabolic process (GO:0034250)3.52119061
37peptide catabolic process (GO:0043171)3.50382310
38* glycosphingolipid catabolic process (GO:0046479)3.49993787
39regulation of mast cell activation involved in immune response (GO:0033006)3.49884017
40detection of biotic stimulus (GO:0009595)3.48379125
41lipopolysaccharide-mediated signaling pathway (GO:0031663)3.41811322
42positive regulation of nuclease activity (GO:0032075)3.36829585
43negative regulation of erythrocyte differentiation (GO:0045647)3.34758125
44granulocyte activation (GO:0036230)3.30292062
45positive regulation of mast cell degranulation (GO:0043306)3.25665509
46positive regulation of mast cell activation involved in immune response (GO:0033008)3.25665509
47regulation of interferon-beta biosynthetic process (GO:0045357)3.25502151
48antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.25099133
49myeloid cell activation involved in immune response (GO:0002275)3.23629433
50regulation of mast cell activation (GO:0033003)3.23283386
51B cell mediated immunity (GO:0019724)3.22944128
52response to muramyl dipeptide (GO:0032495)3.21388565
53G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.21270625
54negative regulation of bone resorption (GO:0045779)3.21072795
55microglial cell activation (GO:0001774)3.20638519
56protein maturation by protein folding (GO:0022417)3.18977068
57amino sugar catabolic process (GO:0046348)3.18491240
58positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.18267109
59endoplasmic reticulum unfolded protein response (GO:0030968)3.18207445
60regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.15443340
61cellular response to unfolded protein (GO:0034620)3.14205212
62positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.12577453
63neutrophil activation (GO:0042119)3.10939097
64interferon-gamma-mediated signaling pathway (GO:0060333)3.10562626
65regulation of gamma-delta T cell activation (GO:0046643)3.09065606
66positive regulation of leukocyte degranulation (GO:0043302)3.08618171
67* glycolipid catabolic process (GO:0019377)3.08213398
68keratan sulfate catabolic process (GO:0042340)3.07796640
69intracellular pH reduction (GO:0051452)3.07757671
70regulation of nuclease activity (GO:0032069)3.07025098
71pinocytosis (GO:0006907)3.05780792
72response to thyroid hormone (GO:0097066)3.03141644
73neutrophil activation involved in immune response (GO:0002283)3.01444324
74regulation of antigen processing and presentation (GO:0002577)3.00870658
75cellular response to topologically incorrect protein (GO:0035967)3.00138122
76macrophage activation involved in immune response (GO:0002281)2.95282206
77ER-nucleus signaling pathway (GO:0006984)2.90138647
78response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.90103655
79response to host (GO:0075136)2.90103655
80response to host defenses (GO:0052200)2.90103655
81negative regulation of cytokine production involved in immune response (GO:0002719)2.89274325
82ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.87277781
83barbed-end actin filament capping (GO:0051016)2.86171041
84L-alpha-amino acid transmembrane transport (GO:1902475)2.85958648
85regulation of tolerance induction (GO:0002643)2.83594379
86positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.82393418
87myeloid dendritic cell differentiation (GO:0043011)2.81643145
88antigen processing and presentation via MHC class Ib (GO:0002475)2.81050354
89positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.80859808
90N-acetylneuraminate metabolic process (GO:0006054)2.80655264
91pH reduction (GO:0045851)2.80644803
92regulation of superoxide anion generation (GO:0032928)2.80490454
93cellular response to type I interferon (GO:0071357)2.80243627
94type I interferon signaling pathway (GO:0060337)2.80243627
95regulation of T cell tolerance induction (GO:0002664)2.79734296
96toxin transport (GO:1901998)2.78990920
97NIK/NF-kappaB signaling (GO:0038061)2.78030408
98vesicle coating (GO:0006901)2.77816205
99myeloid dendritic cell activation (GO:0001773)2.76343087
100response to peptidoglycan (GO:0032494)2.75301710
101regulation of regulated secretory pathway (GO:1903305)2.75155401
102response to type I interferon (GO:0034340)2.75025048
103positive regulation of type 2 immune response (GO:0002830)2.74991391
104regulation of T-helper 2 cell differentiation (GO:0045628)2.71974072
105regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.71810817
106regulation of B cell receptor signaling pathway (GO:0050855)2.71412250
107regulation of type B pancreatic cell apoptotic process (GO:2000674)2.70276500
108ER overload response (GO:0006983)2.69985161
109positive regulation of B cell differentiation (GO:0045579)2.69712778
110regulation of mononuclear cell migration (GO:0071675)2.69252541
111negative regulation of glycoprotein biosynthetic process (GO:0010561)2.69101547
112positive regulation of gamma-delta T cell activation (GO:0046645)2.68997982
113negative regulation of tissue remodeling (GO:0034104)2.68722278
114protein N-linked glycosylation via asparagine (GO:0018279)2.68370230
115response to laminar fluid shear stress (GO:0034616)2.67496728
116exocrine pancreas development (GO:0031017)2.66412602
117positive regulation of interferon-alpha production (GO:0032727)2.66228081
118interleukin-1-mediated signaling pathway (GO:0070498)2.65898172
119negative regulation of leukocyte mediated immunity (GO:0002704)2.65047116
120peptidyl-asparagine modification (GO:0018196)2.64884213
121regulation of podosome assembly (GO:0071801)2.64080448
122regulation of macrophage cytokine production (GO:0010935)2.63994304
123valine metabolic process (GO:0006573)2.63584468
124negative regulation of glycoprotein metabolic process (GO:1903019)2.61456064
125negative regulation of myeloid cell apoptotic process (GO:0033033)2.59322081
126positive regulation of tumor necrosis factor production (GO:0032760)2.58755027
127negative regulation of innate immune response (GO:0045824)2.58677127
128negative regulation of lymphocyte mediated immunity (GO:0002707)2.58673314
129regulation of monocyte chemotaxis (GO:0090025)2.58524885
130respiratory burst (GO:0045730)2.58104205
131positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.57670175
132defense response to protozoan (GO:0042832)2.57269911
133response to endoplasmic reticulum stress (GO:0034976)2.55519391
134UDP-N-acetylglucosamine metabolic process (GO:0006047)2.55398751
135purinergic nucleotide receptor signaling pathway (GO:0035590)2.53235299
136glandular epithelial cell differentiation (GO:0002067)2.51507574
137macroautophagy (GO:0016236)2.50469553
138negative regulation of bone remodeling (GO:0046851)2.50031243
139amyloid precursor protein catabolic process (GO:0042987)2.49889473
140regulation of interferon-alpha production (GO:0032647)2.49546265
141macrophage activation (GO:0042116)2.48713464
142positive regulation of antigen processing and presentation (GO:0002579)2.48692733
143endosome to melanosome transport (GO:0035646)2.47113310
144endosome to pigment granule transport (GO:0043485)2.47113310
145cellular response to vitamin D (GO:0071305)2.45396966
146protein N-linked glycosylation (GO:0006487)2.42382560
147JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.41380664
148hydrogen peroxide biosynthetic process (GO:0050665)2.40114663
1494-hydroxyproline metabolic process (GO:0019471)2.38676027
150mannose metabolic process (GO:0006013)2.35869254
151negative regulation of norepinephrine secretion (GO:0010700)2.35388997
152apoptotic cell clearance (GO:0043277)2.34619670
153eosinophil chemotaxis (GO:0048245)2.33952880
154type B pancreatic cell development (GO:0003323)2.32168691
155response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.32009284
156response to host immune response (GO:0052572)2.32009284
157oligosaccharide catabolic process (GO:0009313)2.31293360
158erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.30185561
159L-phenylalanine catabolic process (GO:0006559)2.30185561
160reactive oxygen species biosynthetic process (GO:1903409)2.28989346
161positive regulation of insulin secretion (GO:0032024)2.28959265
162tricarboxylic acid metabolic process (GO:0072350)2.25881019
163T-helper 1 type immune response (GO:0042088)2.25112866
164ER to Golgi vesicle-mediated transport (GO:0006888)2.24327823
165positive regulation of p38MAPK cascade (GO:1900745)2.23009273
166positive regulation of monocyte chemotaxis (GO:0090026)2.22549026
167glandular epithelial cell development (GO:0002068)2.22034081
168regulation of dendritic cell antigen processing and presentation (GO:0002604)2.19269545
169response to unfolded protein (GO:0006986)2.18979346
170fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.18118016
171regulation of cholesterol homeostasis (GO:2000188)2.17687848

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.84291508
2IRF8_21731497_ChIP-ChIP_J774_Mouse3.67583594
3GATA1_22025678_ChIP-Seq_K562_Human3.52258543
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.19902867
5IRF8_27001747_Chip-Seq_BMDM_Mouse2.80307522
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.75139259
7RXR_22158963_ChIP-Seq_LIVER_Mouse2.74984639
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.71113369
9* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.70185766
10PPARA_22158963_ChIP-Seq_LIVER_Mouse2.57407894
11* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.53343028
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.46499486
13LXR_22158963_ChIP-Seq_LIVER_Mouse2.42396756
14NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.38484594
15* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.28696438
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.15595719
17Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.10356303
18RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.09762113
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.09077756
20SCL_19346495_ChIP-Seq_HPC-7_Human2.06963449
21MYB_21317192_ChIP-Seq_ERMYB_Mouse2.04416838
22CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.02449718
23RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.01189036
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.99015696
25* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.92163863
26ELK3_25401928_ChIP-Seq_HUVEC_Human1.84963368
27LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.75377004
28* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.75355283
29MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.72792518
30CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.72055035
31FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.71648259
32EGR1_19374776_ChIP-ChIP_THP-1_Human1.67857992
33MYC_22102868_ChIP-Seq_BL_Human1.67287895
34LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.66495569
35CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.63111862
36SOX2_27498859_Chip-Seq_STOMACH_Mouse1.63088387
37PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.62005073
38GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.60329405
39KDM2B_26808549_Chip-Seq_SUP-B15_Human1.60270982
40VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.59825057
41* SPI1_23547873_ChIP-Seq_NB4_Human1.59774419
42ESR1_21235772_ChIP-Seq_MCF-7_Human1.58725217
43STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.55470765
44PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.55326979
45SPI1_23127762_ChIP-Seq_K562_Human1.53721972
46VDR_24763502_ChIP-Seq_THP-1_Human1.53546278
47STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.52016875
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.47385689
49CLOCK_20551151_ChIP-Seq_293T_Human1.46768545
50FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.46219538
51E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.46021901
52TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.45516462
53MYB_26560356_Chip-Seq_TH2_Human1.45006866
54EGR1_23403033_ChIP-Seq_LIVER_Mouse1.43326204
55GATA2_21666600_ChIP-Seq_HMVEC_Human1.42777019
56KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.42650203
57ELF1_17652178_ChIP-ChIP_JURKAT_Human1.42560667
58FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.39462359
59TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37198702
60STAT4_19710469_ChIP-ChIP_TH1__Mouse1.37146069
61DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.36796592
62* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.35799190
63GATA3_27048872_Chip-Seq_THYMUS_Human1.35563008
64GATA1_22383799_ChIP-Seq_G1ME_Mouse1.32020261
65RUNX1_22412390_ChIP-Seq_EML_Mouse1.31582675
66SOX2_20726797_ChIP-Seq_SW620_Human1.30573216
67RUNX_20019798_ChIP-Seq_JUKART_Human1.28949533
68TFEB_21752829_ChIP-Seq_HELA_Human1.28659409
69GATA1_19941826_ChIP-Seq_K562_Human1.28438167
70RARG_19884340_ChIP-ChIP_MEFs_Mouse1.26718729
71CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.26464643
72KDM2B_26808549_Chip-Seq_DND41_Human1.24303921
73GATA2_22383799_ChIP-Seq_G1ME_Mouse1.23088427
74CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22798876
75MAF_26560356_Chip-Seq_TH2_Human1.22523947
76TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.22379272
77PU_27001747_Chip-Seq_BMDM_Mouse1.21904979
78RACK7_27058665_Chip-Seq_MCF-7_Human1.21310451
79TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.21195141
80MYB_26560356_Chip-Seq_TH1_Human1.21156926
81GATA3_26560356_Chip-Seq_TH2_Human1.20945730
82TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20871687
83* GATA1_19941827_ChIP-Seq_MEL_Mouse1.18554480
84FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.17208543
85SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.14669616
86SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14357323
87MAF_26560356_Chip-Seq_TH1_Human1.14279482
88SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.14040274
89NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.13597961
90GATA4_25053715_ChIP-Seq_YYC3_Human1.13090893
91VDR_21846776_ChIP-Seq_THP-1_Human1.12864227
92* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10542440
93PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07864703
94ERG_20887958_ChIP-Seq_HPC-7_Mouse1.07687765
95ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.07328099
96TRIM28_21343339_ChIP-Seq_HEK293_Human1.06241422
97THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.05843299
98NCOR1_26117541_ChIP-Seq_K562_Human1.05607174
99PU.1_20513432_ChIP-Seq_Bcells_Mouse1.05533971
100SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.04724608
101CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04231645
102PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03103765
103FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.02146738
104HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.02000386
105GATA2_19941826_ChIP-Seq_K562_Human1.01925672
106CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.00885139
107BCL6_27268052_Chip-Seq_Bcells_Human1.00197146
108NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.99402326
109BCOR_27268052_Chip-Seq_Bcells_Human0.98290068
110EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.98057940
111RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.96846343
112* LXR_22292898_ChIP-Seq_THP-1_Human0.96620235
113KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.96578054
114KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.94964945
115TP63_17297297_ChIP-ChIP_HaCaT_Human0.94912960
116FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.94863709
117ELF1_20517297_ChIP-Seq_JURKAT_Human0.92973162
118TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.92169055
119SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92046449
120UTX_26944678_Chip-Seq_JUKART_Human0.92038354
121AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.91178382
122VDR_24787735_ChIP-Seq_THP-1_Human0.90946687
123TCF7_22412390_ChIP-Seq_EML_Mouse0.89602309

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology3.94392995
2MP0002877_abnormal_melanocyte_morpholog3.79026293
3MP0003183_abnormal_peptide_metabolism3.27218732
4MP0001835_abnormal_antigen_presentation3.14892214
5MP0003172_abnormal_lysosome_physiology2.49597326
6MP0009840_abnormal_foam_cell2.46102173
7MP0003195_calcinosis2.36525010
8MP0002693_abnormal_pancreas_physiology2.34678176
9MP0002139_abnormal_hepatobiliary_system2.29164759
10MP0006082_CNS_inflammation2.17025682
11MP0003300_gastrointestinal_ulcer2.15369617
12MP0010386_abnormal_urinary_bladder2.04344122
13MP0003436_decreased_susceptibility_to2.02944468
14MP0000013_abnormal_adipose_tissue1.95718300
15MP0003191_abnormal_cellular_cholesterol1.94769351
16MP0003724_increased_susceptibility_to1.90385656
17MP0005365_abnormal_bile_salt1.90128546
18MP0005451_abnormal_body_composition1.89728990
19MP0004264_abnormal_extraembryonic_tissu1.86632416
20MP0005671_abnormal_response_to1.86580459
21MP0001944_abnormal_pancreas_morphology1.86156520
22MP0002419_abnormal_innate_immunity1.85266555
23MP0008260_abnormal_autophagy1.81718270
24MP0000685_abnormal_immune_system1.81687240
25MP0002138_abnormal_hepatobiliary_system1.81677966
26MP0005220_abnormal_exocrine_pancreas1.80496587
27MP0000604_amyloidosis1.80025574
28MP0004043_abnormal_pH_regulation1.78388548
29MP0009643_abnormal_urine_homeostasis1.77115707
30MP0002148_abnormal_hypersensitivity_rea1.75063152
31MP0005464_abnormal_platelet_physiology1.74566894
32MP0005310_abnormal_salivary_gland1.71950273
33MP0009780_abnormal_chondrocyte_physiolo1.67986159
34MP0002909_abnormal_adrenal_gland1.65318897
35MP0005000_abnormal_immune_tolerance1.64975242
36MP0001790_abnormal_immune_system1.64703448
37MP0005387_immune_system_phenotype1.64703448
38MP0009785_altered_susceptibility_to1.62559148
39MP0003828_pulmonary_edema1.58855293
40MP0005025_abnormal_response_to1.58333080
41MP0000858_altered_metastatic_potential1.57717301
42MP0001666_abnormal_nutrient_absorption1.54932856
43MP0008004_abnormal_stomach_pH1.54029292
44MP0009278_abnormal_bone_marrow1.53862013
45MP0001533_abnormal_skeleton_physiology1.41992833
46MP0009333_abnormal_splenocyte_physiolog1.41167899
47MP0000678_abnormal_parathyroid_gland1.38283177
48MP0003252_abnormal_bile_duct1.37817769
49MP0001845_abnormal_inflammatory_respons1.37570605
50MP0003866_abnormal_defecation1.37495694
51MP0004510_myositis1.36881556
52MP0002452_abnormal_antigen_presenting1.33003226
53MP0005379_endocrine/exocrine_gland_phen1.32875299
54MP0004883_abnormal_blood_vessel1.29908097
55MP0003283_abnormal_digestive_organ1.28970128
56MP0006054_spinal_hemorrhage1.28593149
57MP0003448_altered_tumor_morphology1.27625017
58MP0002723_abnormal_immune_serum1.27576733
59MP0008469_abnormal_protein_level1.27515043
60MP0002928_abnormal_bile_duct1.27425314
61MP0002078_abnormal_glucose_homeostasis1.27154299
62MP0005397_hematopoietic_system_phenotyp1.26055756
63MP0001545_abnormal_hematopoietic_system1.26055756
64MP0005166_decreased_susceptibility_to1.25353355
65MP0010329_abnormal_lipoprotein_level1.24053706
66MP0001849_ear_inflammation1.22065602
67MP0005085_abnormal_gallbladder_physiolo1.21071552
68MP0001819_abnormal_immune_cell1.21030350
69MP0002405_respiratory_system_inflammati1.20654113
70MP0003705_abnormal_hypodermis_morpholog1.20489436
71MP0002398_abnormal_bone_marrow1.18954833
72MP0001756_abnormal_urination1.17275245
73MP0003303_peritoneal_inflammation1.16717134
74MP0002420_abnormal_adaptive_immunity1.16433734
75MP0008875_abnormal_xenobiotic_pharmacok1.13396392
76MP0005164_abnormal_response_to1.13246296
77MP0003091_abnormal_cell_migration1.12280159
78MP0000609_abnormal_liver_physiology1.11929677
79MP0000689_abnormal_spleen_morphology1.11324658
80MP0010155_abnormal_intestine_physiology1.11041531
81MP0001853_heart_inflammation1.10917480
82MP0005360_urolithiasis1.10525946
83MP0002166_altered_tumor_susceptibility1.09755991
84MP0002429_abnormal_blood_cell1.09016459
85MP0004947_skin_inflammation1.08680882
86MP0002118_abnormal_lipid_homeostasis1.08187293
87MP0008438_abnormal_cutaneous_collagen1.06635923
88MP0002254_reproductive_system_inflammat1.06567493
89MP0001800_abnormal_humoral_immune1.06055335
90MP0004019_abnormal_vitamin_homeostasis1.04876075
91MP0000465_gastrointestinal_hemorrhage1.04701528
92MP0003453_abnormal_keratinocyte_physiol1.04266968
93MP0002722_abnormal_immune_system1.03665987
94MP0001765_abnormal_ion_homeostasis1.03650348
95MP0003075_altered_response_to1.02608484
96MP0003656_abnormal_erythrocyte_physiolo0.99486589
97MP0003186_abnormal_redox_activity0.98596069
98MP0003329_amyloid_beta_deposits0.97658022
99MP0005332_abnormal_amino_acid0.97422473
100MP0002998_abnormal_bone_remodeling0.97022958
101MP0002132_abnormal_respiratory_system0.96527228
102MP0009763_increased_sensitivity_to0.96433277
103MP0000003_abnormal_adipose_tissue0.96219067
104MP0003566_abnormal_cell_adhesion0.95978691
105MP0003795_abnormal_bone_structure0.94686010
106MP0002933_joint_inflammation0.94613561
107MP0005257_abnormal_intraocular_pressure0.94111770
108MP0003279_aneurysm0.94098851
109MP0005636_abnormal_mineral_homeostasis0.94082759
110MP0005390_skeleton_phenotype0.93984608
111MP0004782_abnormal_surfactant_physiolog0.92859994
112MP0003868_abnormal_feces_composition0.92636259
113MP0002136_abnormal_kidney_physiology0.91643367
114MP0009764_decreased_sensitivity_to0.91037788
115MP0002876_abnormal_thyroid_physiology0.90553918
116MP0003690_abnormal_glial_cell0.90003928
117MP0000490_abnormal_crypts_of0.89716231
118MP0005319_abnormal_enzyme/_coenzyme0.89651804
119MP0001851_eye_inflammation0.89575878
120MP0002837_dystrophic_cardiac_calcinosis0.88237695
121MP0003806_abnormal_nucleotide_metabolis0.87627615
122MP0001986_abnormal_taste_sensitivity0.86124477
123MP0001873_stomach_inflammation0.85416685
124MP0000343_altered_response_to0.83454722
125MP0005670_abnormal_white_adipose0.82585172
126MP0005083_abnormal_biliary_tract0.82096483
127MP0000249_abnormal_blood_vessel0.80662612
128MP0005023_abnormal_wound_healing0.80334387
129MP0009642_abnormal_blood_homeostasis0.79965685
130MP0002896_abnormal_bone_mineralization0.79102480
131MP0000371_diluted_coat_color0.79054412
132MP0003763_abnormal_thymus_physiology0.79022616
133MP0001542_abnormal_bone_strength0.78239926
134MP0000598_abnormal_liver_morphology0.77327712
135MP0000716_abnormal_immune_system0.76777669
136MP0001958_emphysema0.76436819
137MP0005167_abnormal_blood-brain_barrier0.75756993
138MP0005076_abnormal_cell_differentiation0.74228791
139MP0005165_increased_susceptibility_to0.73692470
140MP0001663_abnormal_digestive_system0.72924813
141MP0000920_abnormal_myelination0.71010108
142MP0004808_abnormal_hematopoietic_stem0.66580672
143MP0010307_abnormal_tumor_latency0.60591257

Predicted human phenotypes

RankGene SetZ-score
1Increased neuronal autofluorescent lipopigment (HP:0002074)5.43021974
2Vacuolated lymphocytes (HP:0001922)5.39181579
3Increased cerebral lipofuscin (HP:0011813)5.37163827
4Dysostosis multiplex (HP:0000943)4.98139258
5Mucopolysacchariduria (HP:0008155)4.47623532
6Urinary glycosaminoglycan excretion (HP:0003541)4.47623532
7Abnormality of liposaccharide metabolism (HP:0010968)4.44619411
8Abnormality of glycosphingolipid metabolism (HP:0004343)4.44619411
9Abnormality of glycolipid metabolism (HP:0010969)4.44619411
10Abnormality of mucopolysaccharide metabolism (HP:0011020)4.11774682
11Abnormality of polysaccharide metabolism (HP:0011012)4.11774682
12Abnormality of glycosaminoglycan metabolism (HP:0004371)4.11774682
13Hypoglycemic coma (HP:0001325)4.09457185
14Hypoglycemic seizures (HP:0002173)4.00270393
15Symptomatic seizures (HP:0011145)3.75559159
16Hyperinsulinemic hypoglycemia (HP:0000825)3.70817166
17Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.50781721
18Generalized aminoaciduria (HP:0002909)3.38814462
19Purpura (HP:0000979)3.32903936
20Amyloidosis (HP:0011034)3.32827199
21Mediastinal lymphadenopathy (HP:0100721)3.25179391
22Abnormality of the intrinsic pathway (HP:0010989)3.24459471
23Chronic obstructive pulmonary disease (HP:0006510)3.09755929
24Obstructive lung disease (HP:0006536)3.09755929
25Ketoacidosis (HP:0001993)3.09333887
26Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.08403564
27Spontaneous hematomas (HP:0007420)3.07330644
28Late onset (HP:0003584)2.99574735
29Eczematoid dermatitis (HP:0000976)2.98737879
30Recurrent abscess formation (HP:0002722)2.97569766
31Stomatitis (HP:0010280)2.90521579
32Disinhibition (HP:0000734)2.86767614
33Optic neuritis (HP:0100653)2.85982726
34Retrobulbar optic neuritis (HP:0100654)2.85982726
35Recurrent fungal infections (HP:0002841)2.85435451
36Hepatosplenomegaly (HP:0001433)2.84358829
37Recurrent bacterial skin infections (HP:0005406)2.81464462
38Abnormality of macrophages (HP:0004311)2.81009863
39Abnormality of aromatic amino acid family metabolism (HP:0004338)2.77919560
40Chronic mucocutaneous candidiasis (HP:0002728)2.76492065
41Recurrent cutaneous fungal infections (HP:0011370)2.76492065
42Upper motor neuron abnormality (HP:0002127)2.74136943
43Progressive neurologic deterioration (HP:0002344)2.65898773
44Interstitial pulmonary disease (HP:0006530)2.62354712
45Systemic lupus erythematosus (HP:0002725)2.61928505
46Recurrent gram-negative bacterial infections (HP:0005420)2.61893881
47Axonal loss (HP:0003447)2.61216141
48Retinal atrophy (HP:0001105)2.55699580
49Abnormality of the vasculature of the conjunctiva (HP:0008054)2.55540613
50Loss of speech (HP:0002371)2.55004759
51Meningitis (HP:0001287)2.53445480
52Beaking of vertebral bodies (HP:0004568)2.51690321
53Urticaria (HP:0001025)2.48485400
54Increased serum ferritin (HP:0003281)2.48420119
55Hyperglycemia (HP:0003074)2.48023652
56Nuclear cataract (HP:0100018)2.46529338
57Mutism (HP:0002300)2.41529841
58Recurrent viral infections (HP:0004429)2.39184681
59Joint hemorrhage (HP:0005261)2.38614979
60Epistaxis (HP:0000421)2.35447157
61Abnormality of the common coagulation pathway (HP:0010990)2.34930356
62Protuberant abdomen (HP:0001538)2.33866991
63Large for gestational age (HP:0001520)2.30700898
64Insulin-resistant diabetes mellitus (HP:0000831)2.29533150
65Ketosis (HP:0001946)2.29091279
66Abnormality of the nasal mucosa (HP:0000433)2.28853327
67Cellulitis (HP:0100658)2.28550872
68Progressive visual loss (HP:0000529)2.27639975
69Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.27312405
70Gingival bleeding (HP:0000225)2.26239238
71Abnormality of endocrine pancreas physiology (HP:0012093)2.25746936
72Abnormality of the pancreatic islet cells (HP:0006476)2.25746936
73Abdominal distention (HP:0003270)2.22823286
74Hemoptysis (HP:0002105)2.21680276
75Abnormal delayed hypersensitivity skin test (HP:0002963)2.19742228
76Prolonged bleeding time (HP:0003010)2.19318048
77Abnormality of calcium-phosphate metabolism (HP:0100530)2.16945373
78Myositis (HP:0100614)2.16847213
79Cervical subluxation (HP:0003308)2.16800534
80Autoimmune thrombocytopenia (HP:0001973)2.15300170
81Gout (HP:0001997)2.15213725
82Vasculitis (HP:0002633)2.14755896
83Colitis (HP:0002583)2.14466709
84Gastrointestinal infarctions (HP:0005244)2.13617698
85Glomerulonephritis (HP:0000099)2.12160383
86Hematochezia (HP:0002573)2.09975208
87Encephalitis (HP:0002383)2.07606077
88Thoracic kyphosis (HP:0002942)2.06479169
89Conjunctival telangiectasia (HP:0000524)2.05740895
90Xanthomatosis (HP:0000991)2.05641081
91Abnormality of iron homeostasis (HP:0011031)2.04401772
92Abnormality of purine metabolism (HP:0004352)2.02973992
93Abnormality of T cell physiology (HP:0011840)2.02282861
94Prolonged partial thromboplastin time (HP:0003645)2.00809118
95Decreased circulating renin level (HP:0003351)2.00547628
96Increased IgE level (HP:0003212)1.99711550
97Petechiae (HP:0000967)1.99630851
98Increased IgM level (HP:0003496)1.99405192
99Hyperactive renin-angiotensin system (HP:0000841)1.98618887
100Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.98504300
101Abnormal glycosylation (HP:0012345)1.97289576
102Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.97289576
103Abnormal protein N-linked glycosylation (HP:0012347)1.97289576
104Abnormal protein glycosylation (HP:0012346)1.97289576
105Keratoconjunctivitis sicca (HP:0001097)1.96156240
106Neuronal loss in central nervous system (HP:0002529)1.96143195
107Nasal polyposis (HP:0100582)1.95943678
108Ovoid vertebral bodies (HP:0003300)1.94804773
109Elevated erythrocyte sedimentation rate (HP:0003565)1.94367657
110Abnormality of complement system (HP:0005339)1.92988367
111Pustule (HP:0200039)1.92696273
112Inflammation of the large intestine (HP:0002037)1.92284070
113Tetraparesis (HP:0002273)1.91757415
114Bone pain (HP:0002653)1.91603972
115Poor head control (HP:0002421)1.90710941
116Pancreatic islet-cell hyperplasia (HP:0004510)1.90517861
117Osteomyelitis (HP:0002754)1.90093594
118Gastrointestinal inflammation (HP:0004386)1.89182300
119Conjugated hyperbilirubinemia (HP:0002908)1.88532275
120Hypergammaglobulinemia (HP:0010702)1.87429056
121Abnormal pancreas size (HP:0012094)1.86949475
122Abnormal platelet volume (HP:0011876)1.85938248
123Cerebral palsy (HP:0100021)1.85350678
124Neurofibrillary tangles (HP:0002185)1.85214381
125Disproportionate short-trunk short stature (HP:0003521)1.84322677
126Malnutrition (HP:0004395)1.84185936
127Joint stiffness (HP:0001387)1.84072877
128Polyneuropathy (HP:0001271)1.84072116
129Arterial thrombosis (HP:0004420)1.83925568
130Polycythemia (HP:0001901)1.83885377
131Orchitis (HP:0100796)1.83527387
132Thrombocytosis (HP:0001894)1.82131582
133Hypokalemia (HP:0002900)1.82042854
134Asymmetric septal hypertrophy (HP:0001670)1.81866945
135Spondylolisthesis (HP:0003302)1.81550278
136Premature loss of primary teeth (HP:0006323)1.81302061
137IgM deficiency (HP:0002850)1.80970065
138Abnormal platelet function (HP:0011869)1.79461465
139Impaired platelet aggregation (HP:0003540)1.79461465
140Diminished motivation (HP:0000745)1.79020732
141Insulin resistance (HP:0000855)1.78418060
142Abnormality of fatty-acid metabolism (HP:0004359)1.77998154
143Recurrent skin infections (HP:0001581)1.75103889
144Thoracolumbar scoliosis (HP:0002944)1.74559210
145Pathologic fracture (HP:0002756)1.72577653
146Myocardial infarction (HP:0001658)1.72459180
147Periodontitis (HP:0000704)1.72177268
148Pulmonary infiltrates (HP:0002113)1.71432288
149Gingivitis (HP:0000230)1.71242993
150Nephritis (HP:0000123)1.70427507
151Type I transferrin isoform profile (HP:0003642)1.69514500
152Basal ganglia calcification (HP:0002135)1.67756859
153* Cardiomegaly (HP:0001640)1.66158946
154Complement deficiency (HP:0004431)1.66138079
155Abnormality of renin-angiotensin system (HP:0000847)1.64172558
156Hypoplasia of the odontoid process (HP:0003311)1.63013352
157Vertebral compression fractures (HP:0002953)1.61868808
158Abnormality of alkaline phosphatase activity (HP:0004379)1.60835811
159Hyperparathyroidism (HP:0000843)1.60799791
160Abnormal enzyme/coenzyme activity (HP:0012379)1.60274669
161Chronic otitis media (HP:0000389)1.59654580

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.08670366
2INSRR3.85397968
3TAOK33.51103695
4MAPK153.40789924
5PRPF4B2.89543424
6IRAK32.81752557
7TRIB32.66320563
8PASK2.61322256
9FLT32.51573392
10TBK12.26510827
11MAP4K12.13472701
12TYK22.09699351
13FES2.00985819
14IRAK42.00443121
15PTK61.96280341
16FGR1.91094764
17KIT1.78846094
18SIK11.76689651
19ZAP701.70092198
20MAP3K141.68475797
21HIPK21.66843043
22TAOK21.61699216
23JAK31.61062346
24EPHA31.57975878
25TGFBR21.55458870
26JAK11.53622874
27BCKDK1.53277218
28TESK21.50599070
29MAP3K111.50484466
30FGFR41.49916134
31SCYL21.48270896
32GRK71.46778971
33EPHB11.42724883
34FRK1.38874147
35TAOK11.36570531
36NEK91.35978160
37MAP3K21.34965202
38MST1R1.33253356
39IKBKB1.25356531
40BTK1.23274401
41MAP3K131.21405067
42IKBKE1.18917415
43IRAK11.18839888
44TEC1.18651213
45CSK1.18379086
46MAP2K31.16948318
47JAK21.12856014
48ITK1.11522814
49TNK21.10764169
50SMG11.09617296
51TXK1.06355981
52BLK1.04227136
53MOS1.02867317
54CDC42BPA1.02340288
55MAP2K21.00310412
56CSF1R0.99910249
57GRK60.98116614
58MAP3K30.96527836
59SYK0.94938465
60DDR20.94189101
61MET0.92557009
62MST40.92220558
63KSR20.91281288
64MAP3K10.91225640
65PRKD20.89928089
66PIM20.89184702
67PIK3CG0.87767528
68CHUK0.85532864
69YES10.82661202
70FGFR30.82660250
71WNK40.81820641
72MATK0.79760154
73LRRK20.79075376
74NLK0.76934232
75PKN20.76824341
76TTN0.76460562
77ICK0.75621764
78DYRK1B0.75342822
79MARK30.74882823
80LYN0.73719197
81WNK30.73692988
82PDGFRA0.73092359
83MAP3K80.72951092
84MAP3K60.71943987
85ABL20.70017811
86CAMKK20.68783472
87RIPK10.68414359
88MAPK70.67820476
89TGFBR10.67731009
90PTK20.67592347
91EPHA20.67186324
92STK100.65883638
93BMPR20.61905840
94CAMK1D0.61467222
95LCK0.61263836
96RIPK40.58546108
97TIE10.57204794
98MAP3K50.54951238
99MARK20.54850065
100BMPR1B0.53423780
101CDK40.53297274
102PDPK10.52755248
103RPS6KA40.52542560
104PRKG20.52229662
105EPHB20.51750892
106HCK0.51018760
107PIM10.48481727
108RPS6KA20.47989611
109MAP2K60.47777810
110EIF2AK30.47301497
111PDK10.45918842
112IGF1R0.45591919
113BMX0.45165830
114MAPKAPK20.44564777
115PRKCD0.44320278
116FYN0.44169822
117NME20.42221344
118SIK30.40128260
119MAPK120.39038106
120GSK3A0.38683420
121PDK20.38666291
122RET0.37309434
123PRKCH0.37142765
124TRPM70.35910047
125IRAK20.35682867
126DMPK0.35326994
127TESK10.35297794
128RPS6KA60.34956841
129ACVR1B0.34392517
130PAK10.33603008
131PAK40.32906747
132STK240.31020261
133ARAF0.30490627
134NTRK10.30377397
135CDK60.30307506
136KDR0.29434325
137RPS6KL10.29324447
138RPS6KC10.29324447

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049506.01589318
2Protein export_Homo sapiens_hsa030603.87678079
3Other glycan degradation_Homo sapiens_hsa005113.36798348
4Glycosaminoglycan degradation_Homo sapiens_hsa005313.16504641
5* Lysosome_Homo sapiens_hsa041423.06218961
6Sulfur metabolism_Homo sapiens_hsa009202.91235149
7Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.52739365
8Asthma_Homo sapiens_hsa053102.22117612
9Autoimmune thyroid disease_Homo sapiens_hsa053202.20542311
10Graft-versus-host disease_Homo sapiens_hsa053322.20482876
11N-Glycan biosynthesis_Homo sapiens_hsa005101.74322675
12Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.71109292
13Viral myocarditis_Homo sapiens_hsa054161.61987809
14Staphylococcus aureus infection_Homo sapiens_hsa051501.59212256
15Selenocompound metabolism_Homo sapiens_hsa004501.57070672
16Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.53654413
17Pentose and glucuronate interconversions_Homo sapiens_hsa000401.51423832
18Tryptophan metabolism_Homo sapiens_hsa003801.48393630
19Legionellosis_Homo sapiens_hsa051341.48342655
20Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.42450625
21Leishmaniasis_Homo sapiens_hsa051401.40621075
22Antigen processing and presentation_Homo sapiens_hsa046121.39683449
23Folate biosynthesis_Homo sapiens_hsa007901.37415562
24Carbohydrate digestion and absorption_Homo sapiens_hsa049731.36796106
25Galactose metabolism_Homo sapiens_hsa000521.33165915
26Salmonella infection_Homo sapiens_hsa051321.29755336
27SNARE interactions in vesicular transport_Homo sapiens_hsa041301.21721075
28Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.19470773
29Fatty acid degradation_Homo sapiens_hsa000711.19168692
30Vibrio cholerae infection_Homo sapiens_hsa051101.19040543
31ABC transporters_Homo sapiens_hsa020101.17173157
32Histidine metabolism_Homo sapiens_hsa003401.17066113
33Toll-like receptor signaling pathway_Homo sapiens_hsa046201.16680319
34Type I diabetes mellitus_Homo sapiens_hsa049401.15574216
35Complement and coagulation cascades_Homo sapiens_hsa046101.15269483
36Starch and sucrose metabolism_Homo sapiens_hsa005001.15084091
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.14412309
38Herpes simplex infection_Homo sapiens_hsa051681.13506524
39Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.09409813
40Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.05767858
41Pertussis_Homo sapiens_hsa051331.04789814
42NF-kappa B signaling pathway_Homo sapiens_hsa040640.98221004
43Peroxisome_Homo sapiens_hsa041460.98220272
44Osteoclast differentiation_Homo sapiens_hsa043800.97741508
45Phagosome_Homo sapiens_hsa041450.97712979
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.95072002
47Fatty acid metabolism_Homo sapiens_hsa012120.94538782
48Hepatitis B_Homo sapiens_hsa051610.93725908
49Insulin resistance_Homo sapiens_hsa049310.93461783
50Fatty acid elongation_Homo sapiens_hsa000620.92708297
51Amoebiasis_Homo sapiens_hsa051460.87838841
52Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.87165312
53Primary immunodeficiency_Homo sapiens_hsa053400.86867416
54* Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.85956697
55Malaria_Homo sapiens_hsa051440.84829006
56Tuberculosis_Homo sapiens_hsa051520.82936756
57African trypanosomiasis_Homo sapiens_hsa051430.82263622
58Renin-angiotensin system_Homo sapiens_hsa046140.81582338
59Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.81371591
60Sphingolipid metabolism_Homo sapiens_hsa006000.79996449
61Insulin secretion_Homo sapiens_hsa049110.79529276
62Toxoplasmosis_Homo sapiens_hsa051450.78255130
63Primary bile acid biosynthesis_Homo sapiens_hsa001200.76968223
64Vitamin digestion and absorption_Homo sapiens_hsa049770.76845928
65Caffeine metabolism_Homo sapiens_hsa002320.76052372
66Pentose phosphate pathway_Homo sapiens_hsa000300.75785443
67Type II diabetes mellitus_Homo sapiens_hsa049300.73839067
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.73713339
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73316102
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72331604
71Notch signaling pathway_Homo sapiens_hsa043300.72172061
72Rheumatoid arthritis_Homo sapiens_hsa053230.71809982
73Pancreatic cancer_Homo sapiens_hsa052120.68138019
74PPAR signaling pathway_Homo sapiens_hsa033200.67596461
75Measles_Homo sapiens_hsa051620.66725455
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66724907
77Fructose and mannose metabolism_Homo sapiens_hsa000510.65472745
78NOD-like receptor signaling pathway_Homo sapiens_hsa046210.65304799
79Influenza A_Homo sapiens_hsa051640.64923867
80Jak-STAT signaling pathway_Homo sapiens_hsa046300.64783554
81Chronic myeloid leukemia_Homo sapiens_hsa052200.64429667
82T cell receptor signaling pathway_Homo sapiens_hsa046600.63754803
83Prolactin signaling pathway_Homo sapiens_hsa049170.63256000
84Drug metabolism - other enzymes_Homo sapiens_hsa009830.62803376
85TNF signaling pathway_Homo sapiens_hsa046680.62319676
86Intestinal immune network for IgA production_Homo sapiens_hsa046720.62187126
87Fat digestion and absorption_Homo sapiens_hsa049750.62140425
88Bladder cancer_Homo sapiens_hsa052190.61716785
89Epstein-Barr virus infection_Homo sapiens_hsa051690.60172759
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60079306
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.59157443
92Mineral absorption_Homo sapiens_hsa049780.58546796
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.57892691
94Endocytosis_Homo sapiens_hsa041440.57629126
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.57005788
96Prion diseases_Homo sapiens_hsa050200.56906720
97Hematopoietic cell lineage_Homo sapiens_hsa046400.56626272
98Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55475197
99RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.53440648
100Protein digestion and absorption_Homo sapiens_hsa049740.53344950
101Apoptosis_Homo sapiens_hsa042100.53314726
102Collecting duct acid secretion_Homo sapiens_hsa049660.53154199
103Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53012802
104B cell receptor signaling pathway_Homo sapiens_hsa046620.51455502
105Regulation of autophagy_Homo sapiens_hsa041400.51400719
106Hepatitis C_Homo sapiens_hsa051600.49486014
107HTLV-I infection_Homo sapiens_hsa051660.49278109
108Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.48450053
109Glutathione metabolism_Homo sapiens_hsa004800.48144375
110Non-small cell lung cancer_Homo sapiens_hsa052230.46810465
111Viral carcinogenesis_Homo sapiens_hsa052030.46122998
112Chemokine signaling pathway_Homo sapiens_hsa040620.45702640
113Phenylalanine metabolism_Homo sapiens_hsa003600.45490651
114Acute myeloid leukemia_Homo sapiens_hsa052210.45440019
115VEGF signaling pathway_Homo sapiens_hsa043700.44118364
116Neurotrophin signaling pathway_Homo sapiens_hsa047220.43606573
117Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.43416186
118Systemic lupus erythematosus_Homo sapiens_hsa053220.43140691
119Renal cell carcinoma_Homo sapiens_hsa052110.41712030
120Pancreatic secretion_Homo sapiens_hsa049720.40735968
121Arachidonic acid metabolism_Homo sapiens_hsa005900.40487689
122beta-Alanine metabolism_Homo sapiens_hsa004100.39230389
123Leukocyte transendothelial migration_Homo sapiens_hsa046700.38583800
124Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.38226396
125Shigellosis_Homo sapiens_hsa051310.36191537
126HIF-1 signaling pathway_Homo sapiens_hsa040660.35957491
127Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.35819411
128Platelet activation_Homo sapiens_hsa046110.35778427
129Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.35551348
130Lysine degradation_Homo sapiens_hsa003100.34597279
131Butanoate metabolism_Homo sapiens_hsa006500.33558020
132Allograft rejection_Homo sapiens_hsa053300.31984103
133Chemical carcinogenesis_Homo sapiens_hsa052040.31850139
134Circadian rhythm_Homo sapiens_hsa047100.31794511
135Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.30870986
136Transcriptional misregulation in cancer_Homo sapiens_hsa052020.24364328
137Phospholipase D signaling pathway_Homo sapiens_hsa040720.22506482
138Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.20031095

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