NAGLU

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme that degrades heparan sulfate by hydrolysis of terminal N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides. Defects in this gene are the cause of mucopolysaccharidosis type IIIB (MPS-IIIB), also known as Sanfilippo syndrome B. This disease is characterized by the lysosomal accumulation and urinary excretion of heparan sulfate. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.21186945
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.21186945
3regulation of interferon-beta biosynthetic process (GO:0045357)4.06013781
4positive regulation by symbiont of host defense response (GO:0052509)3.99280312
5modulation by symbiont of host defense response (GO:0052031)3.99280312
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.99280312
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.99280312
8positive regulation by organism of defense response of other organism involved in symbiotic interact3.99280312
9modulation by symbiont of host immune response (GO:0052553)3.99280312
10apoptotic cell clearance (GO:0043277)3.84665527
11peptidyl-glutamic acid carboxylation (GO:0017187)3.84331271
12protein carboxylation (GO:0018214)3.84331271
13mannose metabolic process (GO:0006013)3.84214052
14barbed-end actin filament capping (GO:0051016)3.77193991
15adhesion of symbiont to host (GO:0044406)3.69132396
16complement activation, alternative pathway (GO:0006957)3.69064909
17macrophage activation involved in immune response (GO:0002281)3.64655362
18glycosphingolipid catabolic process (GO:0046479)3.61709205
19antigen processing and presentation of endogenous antigen (GO:0019883)3.59250110
20fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.54156702
21low-density lipoprotein particle clearance (GO:0034383)3.51680139
22detection of molecule of bacterial origin (GO:0032490)3.49678043
23regulation of extracellular matrix disassembly (GO:0010715)3.45823498
24virion attachment to host cell (GO:0019062)3.45722935
25adhesion of symbiont to host cell (GO:0044650)3.45722935
26protein localization to endosome (GO:0036010)3.44196653
27alpha-linolenic acid metabolic process (GO:0036109)3.43712546
28regulation of protein activation cascade (GO:2000257)3.37594728
29regulation of complement activation (GO:0030449)3.37271868
30tyrosine metabolic process (GO:0006570)3.36652912
31positive regulation of extracellular matrix organization (GO:1903055)3.33812565
32Golgi transport vesicle coating (GO:0048200)3.28635017
33COPI coating of Golgi vesicle (GO:0048205)3.28635017
34L-phenylalanine metabolic process (GO:0006558)3.27871866
35erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.27871866
36pinocytosis (GO:0006907)3.27728520
37glycolipid catabolic process (GO:0019377)3.26825363
38erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.26699937
39L-phenylalanine catabolic process (GO:0006559)3.26699937
40keratan sulfate catabolic process (GO:0042340)3.25270662
41plasma lipoprotein particle clearance (GO:0034381)3.24835702
42hyaluronan catabolic process (GO:0030214)3.24198353
43regulation of cholesterol storage (GO:0010885)3.23085932
44sulfur amino acid catabolic process (GO:0000098)3.18396265
45antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.15399564
46skin morphogenesis (GO:0043589)3.15116529
47oligosaccharide catabolic process (GO:0009313)3.13939935
48positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.07003668
49regulation of early endosome to late endosome transport (GO:2000641)3.05050911
50opsonization (GO:0008228)3.02936749
51regulation of cholesterol esterification (GO:0010872)3.00997635
52positive regulation of triglyceride lipase activity (GO:0061365)2.99535759
53positive regulation of lipoprotein lipase activity (GO:0051006)2.99535759
54triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.98674882
55negative regulation of erythrocyte differentiation (GO:0045647)2.96636497
56regulation of apoptotic cell clearance (GO:2000425)2.94746829
57positive regulation of interferon-alpha production (GO:0032727)2.94152646
58amino sugar catabolic process (GO:0046348)2.92990669
59negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.90112197
60urea cycle (GO:0000050)2.86127855
61urea metabolic process (GO:0019627)2.86127855
62glyoxylate metabolic process (GO:0046487)2.85715239
63valine metabolic process (GO:0006573)2.84566081
644-hydroxyproline metabolic process (GO:0019471)2.83306355
65response to thyroid hormone (GO:0097066)2.82680414
66positive regulation of coagulation (GO:0050820)2.81787836
67stress fiber assembly (GO:0043149)2.81660976
68positive regulation of hemostasis (GO:1900048)2.81616578
69positive regulation of blood coagulation (GO:0030194)2.81616578
70positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.81470624
71aromatic amino acid family catabolic process (GO:0009074)2.80884358
72regulation of plasminogen activation (GO:0010755)2.78402635
73complement activation (GO:0006956)2.78000087
74negative regulation of fibrinolysis (GO:0051918)2.77758303
75regulation of interferon-alpha production (GO:0032647)2.75644162
76endodermal cell differentiation (GO:0035987)2.71907068
77cysteine metabolic process (GO:0006534)2.71564167
78response to laminar fluid shear stress (GO:0034616)2.71069665
79complement activation, classical pathway (GO:0006958)2.70597143
80ceramide catabolic process (GO:0046514)2.70505567
81regulation of extracellular matrix organization (GO:1903053)2.69703180
82amyloid precursor protein catabolic process (GO:0042987)2.65065240
83cellular response to thyroid hormone stimulus (GO:0097067)2.64766668
84nitrogen cycle metabolic process (GO:0071941)2.59240194
85tooth mineralization (GO:0034505)2.58125176
86embryo implantation (GO:0007566)2.57504965
87cellular modified amino acid catabolic process (GO:0042219)2.56448742
88maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.55096918
89regulation of cholesterol homeostasis (GO:2000188)2.54836520
90positive regulation of cholesterol efflux (GO:0010875)2.54722810
91bile acid biosynthetic process (GO:0006699)2.54244027
92reverse cholesterol transport (GO:0043691)2.53950722
93retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.52908437
94positive regulation of endothelial cell apoptotic process (GO:2000353)2.52553895
95high-density lipoprotein particle remodeling (GO:0034375)2.51917892
96regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.51536409
97aldehyde catabolic process (GO:0046185)2.51019968
98pentose-phosphate shunt (GO:0006098)2.50899822
99protein activation cascade (GO:0072376)2.50694335
100sphingolipid catabolic process (GO:0030149)2.49474625
101membrane lipid catabolic process (GO:0046466)2.48786057
102macrophage activation (GO:0042116)2.48670398
103kynurenine metabolic process (GO:0070189)2.48038017
104melanin biosynthetic process (GO:0042438)2.47754454
105negative regulation of fatty acid transport (GO:2000192)2.47748224
106ethanol oxidation (GO:0006069)2.46925262
107regulation of fibrinolysis (GO:0051917)2.46845226
108L-alpha-amino acid transmembrane transport (GO:1902475)2.45447204
109regulation of glucose import in response to insulin stimulus (GO:2001273)2.44731760
110cell adhesion mediated by integrin (GO:0033627)2.44117630
111negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.43504947
112positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.43113887
113response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.42897442
114response to host immune response (GO:0052572)2.42897442
115fibrinolysis (GO:0042730)2.42810535
116NADPH regeneration (GO:0006740)2.42730443
117N-acetylneuraminate metabolic process (GO:0006054)2.42550906
118positive regulation of receptor recycling (GO:0001921)2.42541676
119lipoprotein metabolic process (GO:0042157)2.42090707
120peptide catabolic process (GO:0043171)2.41692693
121cholesterol efflux (GO:0033344)2.41443151
122lysine metabolic process (GO:0006553)2.41322877
123lysine catabolic process (GO:0006554)2.41322877
1242-oxoglutarate metabolic process (GO:0006103)2.41141961
125protein heterotrimerization (GO:0070208)2.41054228
126tryptophan metabolic process (GO:0006568)2.40498182
127acute-phase response (GO:0006953)2.40210553
128amino-acid betaine metabolic process (GO:0006577)2.40015636
129endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.39176880
130homocysteine metabolic process (GO:0050667)2.38759576
131positive regulation of triglyceride biosynthetic process (GO:0010867)2.38240843
132indole-containing compound catabolic process (GO:0042436)2.37946983
133indolalkylamine catabolic process (GO:0046218)2.37946983
134tryptophan catabolic process (GO:0006569)2.37946983
135basement membrane organization (GO:0071711)2.37755372
136aromatic amino acid family metabolic process (GO:0009072)2.37350469
137phospholipid efflux (GO:0033700)2.37149385
138epithelial cell-cell adhesion (GO:0090136)2.37138356
139protein retention in ER lumen (GO:0006621)2.37101634
140regulation of cholesterol biosynthetic process (GO:0045540)2.36510701
141regulation of membrane protein ectodomain proteolysis (GO:0051043)2.35976516
142negative regulation of lipid transport (GO:0032369)2.35677966
143activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.35290497
144regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.34384237
145vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.34193345
146regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.34092762
147neutrophil activation involved in immune response (GO:0002283)2.33064389
148bile acid metabolic process (GO:0008206)2.32714406
149protein-lipid complex assembly (GO:0065005)2.32101859
150positive regulation of natural killer cell differentiation (GO:0032825)2.31170969
151glucose 6-phosphate metabolic process (GO:0051156)2.30231981
152hyaluronan metabolic process (GO:0030212)2.29154647
153cell migration involved in heart development (GO:0060973)2.28501041
154collagen metabolic process (GO:0032963)2.27979828
155plasma lipoprotein particle assembly (GO:0034377)2.27753761
156proline biosynthetic process (GO:0006561)2.27294654
157modulation by symbiont of host cellular process (GO:0044068)2.26649684
158regulation of mononuclear cell migration (GO:0071675)2.25298951
159vascular endothelial growth factor signaling pathway (GO:0038084)2.24594043
160glucose catabolic process (GO:0006007)2.23694295
161decidualization (GO:0046697)2.23584280
162semaphorin-plexin signaling pathway (GO:0071526)2.23425606
163glial cell migration (GO:0008347)2.22774099

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.54955760
2* RXR_22158963_ChIP-Seq_LIVER_Mouse4.05286208
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.93598950
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.71466632
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.39770551
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.38445601
7* LXR_22158963_ChIP-Seq_LIVER_Mouse3.25426895
8IRF8_27001747_Chip-Seq_BMDM_Mouse2.70981974
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.66297051
10* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.56009606
11NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.52693614
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.42852789
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.40318797
14Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.37526679
15EGR1_23403033_ChIP-Seq_LIVER_Mouse2.36873473
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.32062948
17* FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.25864708
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.19448154
19MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.16301696
20IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.04574685
21CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.04049661
22CLOCK_20551151_ChIP-Seq_293T_Human2.01737377
23EGR1_19374776_ChIP-ChIP_THP-1_Human1.99503047
24BRD4_27068464_Chip-Seq_AML-cells_Mouse1.98311177
25ZNF263_19887448_ChIP-Seq_K562_Human1.96910085
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.96581983
27RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.95527505
28TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.90052999
29STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.81938558
30* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.79757115
31VDR_21846776_ChIP-Seq_THP-1_Human1.76342960
32TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.71619483
33CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.68508873
34* LXR_22292898_ChIP-Seq_THP-1_Human1.68062120
35CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.67845796
36IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.67215611
37* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.65956172
38NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.63478718
39* ELK3_25401928_ChIP-Seq_HUVEC_Human1.61599272
40SCL_19346495_ChIP-Seq_HPC-7_Human1.59364531
41VDR_24763502_ChIP-Seq_THP-1_Human1.51373222
42STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.51303077
43KDM2B_26808549_Chip-Seq_K562_Human1.49191499
44GATA1_22025678_ChIP-Seq_K562_Human1.49078935
45UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.48077889
46TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.47039372
47STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.45042443
48* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.42725469
49* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.40863174
50TRIM28_21343339_ChIP-Seq_HEK293_Human1.39142420
51SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.37182939
52CTCF_27219007_Chip-Seq_ERYTHROID_Human1.36678585
53PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.36383865
54SPI1_23127762_ChIP-Seq_K562_Human1.35274044
55P300_27058665_Chip-Seq_ZR-75-30cells_Human1.35155247
56TET1_21451524_ChIP-Seq_MESCs_Mouse1.35028914
57MAF_26560356_Chip-Seq_TH1_Human1.32575919
58SA1_27219007_Chip-Seq_ERYTHROID_Human1.32456770
59STAT6_21828071_ChIP-Seq_BEAS2B_Human1.32201890
60SRY_22984422_ChIP-ChIP_TESTIS_Rat1.31453354
61SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.28762462
62GATA2_21666600_ChIP-Seq_HMVEC_Human1.28702415
63* RUNX1_22412390_ChIP-Seq_EML_Mouse1.28392853
64TCF7_22412390_ChIP-Seq_EML_Mouse1.26871256
65RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.25589545
66EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.24074339
67* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23348620
68TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23286492
69ESR2_21235772_ChIP-Seq_MCF-7_Human1.23101810
70SPI1_23547873_ChIP-Seq_NB4_Human1.23081052
71KDM2B_26808549_Chip-Seq_SUP-B15_Human1.22888788
72ATF3_27146783_Chip-Seq_COLON_Human1.22691021
73DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.22433916
74ESR1_21235772_ChIP-Seq_MCF-7_Human1.22363167
75P68_20966046_ChIP-Seq_HELA_Human1.21985553
76MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.20892309
77PU_27001747_Chip-Seq_BMDM_Mouse1.19469424
78KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.18673409
79ERG_21242973_ChIP-ChIP_JURKAT_Human1.18665457
80TP53_22127205_ChIP-Seq_IMR90_Human1.18275926
81CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17802145
82SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17486924
83WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.17479115
84EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16972543
85TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16788201
86ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.16557795
87NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.15678423
88RACK7_27058665_Chip-Seq_MCF-7_Human1.13746239
89* SMC4_20622854_ChIP-Seq_HELA_Human1.13111891
90TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.13018048
91FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.12571364
92MYC_22102868_ChIP-Seq_BL_Human1.10964102
93* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.10758526
94ZFP281_18757296_ChIP-ChIP_E14_Mouse1.10596760
95* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.10224532
96* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.09806516
97* ELF1_20517297_ChIP-Seq_JURKAT_Human1.08358144
98PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.08198232
99ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.08046964
100UBF1/2_26484160_Chip-Seq_HMECs_Human1.07516401
101NCOR1_26117541_ChIP-Seq_K562_Human1.06825014
102KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.05513257
103STAT4_19710469_ChIP-ChIP_TH1__Mouse1.05337670
104MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.04859803
105P63_26484246_Chip-Seq_KERATINOCYTES_Human1.04762195
106UTX_26944678_Chip-Seq_JUKART_Human1.04742911
107DNAJC2_21179169_ChIP-ChIP_NT2_Human1.04040866
108SOX2_27498859_Chip-Seq_STOMACH_Mouse1.03743210
109* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03299437
110BCOR_27268052_Chip-Seq_Bcells_Human1.01735670
111STAT3_1855785_ChIP-Seq_MESCs_Mouse1.01728263
112* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.01557933
113ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.01382781
114TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.01374229
115HIF1A_21447827_ChIP-Seq_MCF-7_Human1.01042689
116* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.00859063
117VDR_24787735_ChIP-Seq_THP-1_Human1.00628479
118MYB_26560356_Chip-Seq_TH2_Human1.00150579
119* KDM2B_26808549_Chip-Seq_JURKAT_Human1.00076192
120STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.99832599
121* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.99740603
122HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.99221130
123RUNX_20019798_ChIP-Seq_JUKART_Human0.99070615
124GATA1_19941827_ChIP-Seq_MEL_Mouse0.99047417
125GATA1_19941826_ChIP-Seq_K562_Human0.97225412
126* TFEB_21752829_ChIP-Seq_HELA_Human0.96877642
127NFIB_24661679_ChIP-Seq_LUNG_Mouse0.96681371
128HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.94871250
129FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.94702214
130* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.94252992
131SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.93434377
132* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93408906
133* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93182863
134SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93150793
135NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.92838752
136KDM2B_26808549_Chip-Seq_DND41_Human0.92699840
137* MYB_26560356_Chip-Seq_TH1_Human0.92692211
138TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.91392434
139TP63_17297297_ChIP-ChIP_HaCaT_Human0.91290603
140GATA2_19941826_ChIP-Seq_K562_Human0.89940781
141FOXO3_23340844_ChIP-Seq_DLD1_Human0.89660469
142* FOXA2_19822575_ChIP-Seq_HepG2_Human0.89405085
143* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.89256005

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0005058_abnormal_lysosome_morphology3.60376675
2MP0008438_abnormal_cutaneous_collagen3.52724332
3MP0002139_abnormal_hepatobiliary_system3.34924554
4MP0009840_abnormal_foam_cell3.23084067
5MP0005360_urolithiasis3.17911594
6MP0003191_abnormal_cellular_cholesterol2.93374484
7MP0003172_abnormal_lysosome_physiology2.59805670
8MP0005365_abnormal_bile_salt2.57790651
9MP0006082_CNS_inflammation2.49420988
10MP0003705_abnormal_hypodermis_morpholog2.42803683
11MP0005451_abnormal_body_composition2.35681208
12MP0004272_abnormal_basement_membrane2.20194037
13MP0003436_decreased_susceptibility_to2.18420400
14MP0003300_gastrointestinal_ulcer2.17447933
15MP0008875_abnormal_xenobiotic_pharmacok2.10940704
16MP0003303_peritoneal_inflammation2.05558639
17MP0005085_abnormal_gallbladder_physiolo2.04259159
18MP0003252_abnormal_bile_duct2.00954084
19MP0001835_abnormal_antigen_presentation1.99125651
20MP0005257_abnormal_intraocular_pressure1.90040724
21MP0001958_emphysema1.84993539
22MP0002419_abnormal_innate_immunity1.78939148
23MP0004858_abnormal_nervous_system1.78594549
24MP0010329_abnormal_lipoprotein_level1.73272408
25MP0005464_abnormal_platelet_physiology1.72731813
26MP0005503_abnormal_tendon_morphology1.68335018
27MP0003195_calcinosis1.65876879
28MP0005083_abnormal_biliary_tract1.62792792
29MP0003724_increased_susceptibility_to1.58924955
30MP0003329_amyloid_beta_deposits1.57346884
31MP0008260_abnormal_autophagy1.56767988
32MP0001533_abnormal_skeleton_physiology1.56648245
33MP0003091_abnormal_cell_migration1.54900917
34MP0000604_amyloidosis1.51698224
35MP0003566_abnormal_cell_adhesion1.46951024
36MP0000609_abnormal_liver_physiology1.45804021
37MP0009384_cardiac_valve_regurgitation1.44318538
38MP0005387_immune_system_phenotype1.41207504
39MP0001790_abnormal_immune_system1.41207504
40MP0009643_abnormal_urine_homeostasis1.40802006
41MP0003453_abnormal_keratinocyte_physiol1.39256292
42MP0003279_aneurysm1.37899535
43MP0004510_myositis1.36115396
44MP0008469_abnormal_protein_level1.35291898
45MP0001542_abnormal_bone_strength1.34576784
46MP0005332_abnormal_amino_acid1.33775880
47MP0005025_abnormal_response_to1.33377478
48MP0000685_abnormal_immune_system1.33371596
49MP0000372_irregular_coat_pigmentation1.32949248
50MP0006054_spinal_hemorrhage1.32600229
51MP0002998_abnormal_bone_remodeling1.31910952
52MP0005000_abnormal_immune_tolerance1.27635828
53MP0009785_altered_susceptibility_to1.26665869
54MP0002254_reproductive_system_inflammat1.25337600
55MP0000371_diluted_coat_color1.24615967
56MP0005670_abnormal_white_adipose1.24298111
57MP0001845_abnormal_inflammatory_respons1.23002979
58MP0005076_abnormal_cell_differentiation1.21589713
59MP0002452_abnormal_antigen_presenting1.20337910
60MP0004019_abnormal_vitamin_homeostasis1.19735165
61MP0005319_abnormal_enzyme/_coenzyme1.19559148
62MP0004947_skin_inflammation1.19297640
63MP0002118_abnormal_lipid_homeostasis1.18082712
64MP0002060_abnormal_skin_morphology1.17702389
65MP0002138_abnormal_hepatobiliary_system1.17630134
66MP0003075_altered_response_to1.14566434
67MP0002877_abnormal_melanocyte_morpholog1.12171856
68MP0005023_abnormal_wound_healing1.12090889
69MP0002896_abnormal_bone_mineralization1.10302390
70MP0005275_abnormal_skin_tensile1.09560410
71MP0009764_decreased_sensitivity_to1.09556022
72MP0000343_altered_response_to1.09081176
73MP0005408_hypopigmentation1.08143152
74MP0002148_abnormal_hypersensitivity_rea1.07341925
75MP0002933_joint_inflammation1.07132341
76MP0000003_abnormal_adipose_tissue1.05832471
77MP0010368_abnormal_lymphatic_system1.05518626
78MP0003806_abnormal_nucleotide_metabolis1.05174464
79MP0001666_abnormal_nutrient_absorption1.05171204
80* MP0000598_abnormal_liver_morphology1.04440263
81MP0001800_abnormal_humoral_immune1.04135663
82MP0010234_abnormal_vibrissa_follicle1.03712834
83MP0002723_abnormal_immune_serum1.03668921
84MP0005375_adipose_tissue_phenotype1.01857618
85MP0005508_abnormal_skeleton_morphology1.00818813
86MP0003183_abnormal_peptide_metabolism0.99527720
87MP0000465_gastrointestinal_hemorrhage0.99346883
88MP0002136_abnormal_kidney_physiology0.97431201
89MP0003690_abnormal_glial_cell0.97224723
90MP0005584_abnormal_enzyme/coenzyme_acti0.96130285
91MP0003186_abnormal_redox_activity0.95406935
92MP0003656_abnormal_erythrocyte_physiolo0.94908494
93MP0002089_abnormal_postnatal_growth/wei0.94352487
94MP0005409_darkened_coat_color0.93332915
95MP0009278_abnormal_bone_marrow0.93300485
96MP0001243_abnormal_dermal_layer0.92528143
97MP0001915_intracranial_hemorrhage0.92243117
98MP0005166_decreased_susceptibility_to0.92229030
99MP0000249_abnormal_blood_vessel0.92060576
100MP0001756_abnormal_urination0.91998802
101MP0005164_abnormal_response_to0.91850845
102MP0001853_heart_inflammation0.91814269
103MP0000681_abnormal_thyroid_gland0.91619123
104MP0001819_abnormal_immune_cell0.91485108
105MP0002295_abnormal_pulmonary_circulatio0.91452535
106MP0002090_abnormal_vision0.91433743
107MP0002420_abnormal_adaptive_immunity0.90858863
108MP0005165_increased_susceptibility_to0.90093441
109* MP0001849_ear_inflammation0.89856679
110MP0001661_extended_life_span0.89128987
111MP0003448_altered_tumor_morphology0.87235120
112MP0005666_abnormal_adipose_tissue0.87170489
113MP0005220_abnormal_exocrine_pancreas0.86867743
114MP0009763_increased_sensitivity_to0.85957631
115MP0003634_abnormal_glial_cell0.85162514
116MP0000751_myopathy0.84975620
117MP0000858_altered_metastatic_potential0.84766991
118MP0010307_abnormal_tumor_latency0.84498115
119MP0003795_abnormal_bone_structure0.84258344
120MP0001851_eye_inflammation0.83606156
121MP0005390_skeleton_phenotype0.82597033
122MP0002405_respiratory_system_inflammati0.82317231
123MP0009333_abnormal_splenocyte_physiolog0.82129041
124MP0005623_abnormal_meninges_morphology0.80791931
125MP0010155_abnormal_intestine_physiology0.80147335
126MP0000767_abnormal_smooth_muscle0.80136431
127MP0005595_abnormal_vascular_smooth0.79425515
128MP0002166_altered_tumor_susceptibility0.79002439
129MP0000569_abnormal_digit_pigmentation0.78621733
130MP0004233_abnormal_muscle_weight0.77496584
131MP0002168_other_aberrant_phenotype0.76536455
132MP0004185_abnormal_adipocyte_glucose0.75675846
133MP0004130_abnormal_muscle_cell0.75507330
134MP0002971_abnormal_brown_adipose0.74671475
135* MP0002135_abnormal_kidney_morphology0.74492323
136MP0005171_absent_coat_pigmentation0.72197413
137MP0004883_abnormal_blood_vessel0.71585540
138MP0005397_hematopoietic_system_phenotyp0.69611395
139MP0001545_abnormal_hematopoietic_system0.69611395

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)5.20906549
2Vacuolated lymphocytes (HP:0001922)4.78868182
3* Dysostosis multiplex (HP:0000943)4.55174357
4Increased cerebral lipofuscin (HP:0011813)4.54426423
5* Mucopolysacchariduria (HP:0008155)4.14337095
6* Urinary glycosaminoglycan excretion (HP:0003541)4.14337095
7Complement deficiency (HP:0004431)4.02837651
8* Abnormality of mucopolysaccharide metabolism (HP:0011020)3.88815363
9* Abnormality of polysaccharide metabolism (HP:0011012)3.88815363
10* Abnormality of glycosaminoglycan metabolism (HP:0004371)3.88815363
11Increased neuronal autofluorescent lipopigment (HP:0002074)3.85330068
12Glomerulonephritis (HP:0000099)3.75315121
13Deep venous thrombosis (HP:0002625)3.56695928
14Abnormality of glycolipid metabolism (HP:0010969)3.52120324
15Abnormality of liposaccharide metabolism (HP:0010968)3.52120324
16Abnormality of glycosphingolipid metabolism (HP:0004343)3.52120324
17Abnormality of complement system (HP:0005339)3.38264607
18Recurrent gram-negative bacterial infections (HP:0005420)3.20846919
19Xanthomatosis (HP:0000991)3.20831866
20Myocardial infarction (HP:0001658)3.18810558
21Loss of speech (HP:0002371)3.17276176
22Abnormality of aromatic amino acid family metabolism (HP:0004338)3.08687556
23Cerebral aneurysm (HP:0004944)3.00325295
24Axonal loss (HP:0003447)2.87537767
25Recurrent abscess formation (HP:0002722)2.85952473
26Eczematoid dermatitis (HP:0000976)2.83200307
27Cervical subluxation (HP:0003308)2.77160524
28Premature rupture of membranes (HP:0001788)2.75263277
29Abnormality of macrophages (HP:0004311)2.74392477
30Nephritis (HP:0000123)2.72943119
31Joint hemorrhage (HP:0005261)2.72746720
32Recurrent bacterial skin infections (HP:0005406)2.72200796
33Protrusio acetabuli (HP:0003179)2.66513947
34Nuclear cataract (HP:0100018)2.66477129
35Abnormality of monocarboxylic acid metabolism (HP:0010996)2.64804690
36Ankle contracture (HP:0006466)2.64208321
37Achilles tendon contracture (HP:0001771)2.62685584
38Abnormality of the Achilles tendon (HP:0005109)2.59259201
39Abnormality of glutamine family amino acid metabolism (HP:0010902)2.58263214
40Thin bony cortex (HP:0002753)2.57283005
41Aortic aneurysm (HP:0004942)2.53722214
42J-shaped sella turcica (HP:0002680)2.51483451
43Spondylolisthesis (HP:0003302)2.49724732
44Intrahepatic cholestasis (HP:0001406)2.49022008
45Biconcave vertebral bodies (HP:0004586)2.48426083
46Abnormality of the common coagulation pathway (HP:0010990)2.46870766
47Blue sclerae (HP:0000592)2.46467515
48Vertebral compression fractures (HP:0002953)2.44416344
49Abnormality of the vasculature of the conjunctiva (HP:0008054)2.41425123
50Neurofibrillary tangles (HP:0002185)2.39321194
51Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.37976312
52Aortic dissection (HP:0002647)2.33826872
53Wormian bones (HP:0002645)2.33698155
54Retinal atrophy (HP:0001105)2.32602640
55Hemorrhage of the eye (HP:0011885)2.28867694
56Peritonitis (HP:0002586)2.28743320
57Mitral stenosis (HP:0001718)2.27770762
58* Asymmetric septal hypertrophy (HP:0001670)2.26330297
59Abnormality of proline metabolism (HP:0010907)2.22580547
60Hydroxyprolinuria (HP:0003080)2.22580547
61Upper limb amyotrophy (HP:0009129)2.20273961
62Distal upper limb amyotrophy (HP:0007149)2.20273961
63Prolonged partial thromboplastin time (HP:0003645)2.18154818
64Fragile skin (HP:0001030)2.17628965
65Bladder diverticulum (HP:0000015)2.15347573
66Spinal rigidity (HP:0003306)2.14925158
67Hypoalphalipoproteinemia (HP:0003233)2.14834277
68Interstitial pulmonary disease (HP:0006530)2.14223996
69Beaking of vertebral bodies (HP:0004568)2.13927633
70Abnormality of the intrinsic pathway (HP:0010989)2.13916948
71Arterial tortuosity (HP:0005116)2.13457244
72Abnormality of the nasal mucosa (HP:0000433)2.13308853
73Thoracic kyphosis (HP:0002942)2.12921763
74Gingival bleeding (HP:0000225)2.12705988
75Dilatation of the ascending aorta (HP:0005111)2.12057503
76Cerebral inclusion bodies (HP:0100314)2.12019702
77Hyperlipoproteinemia (HP:0010980)2.11647412
78Vascular tortuosity (HP:0004948)2.11354728
79Ulnar bowing (HP:0003031)2.10161559
80Increased variability in muscle fiber diameter (HP:0003557)2.10031676
81Increased CSF protein (HP:0002922)2.09664775
82Abnormality of dentin (HP:0010299)2.06756415
83Purpura (HP:0000979)2.06651849
84Global brain atrophy (HP:0002283)2.06594948
85Skin nodule (HP:0200036)2.06431079
86Ketosis (HP:0001946)2.06148992
87Increased connective tissue (HP:0009025)2.03977024
88Atrophic scars (HP:0001075)2.03807248
89Nasal polyposis (HP:0100582)2.03733030
90Genu recurvatum (HP:0002816)2.03715087
91Impaired platelet aggregation (HP:0003540)2.01298098
92Abnormal platelet function (HP:0011869)2.01298098
93Hematochezia (HP:0002573)2.01214934
94Hypoglycemic coma (HP:0001325)2.01098563
95Abnormality of the lumbar spine (HP:0100712)2.00288925
96Pathologic fracture (HP:0002756)2.00110926
97Menorrhagia (HP:0000132)1.99911310
98Hyperacusis (HP:0010780)1.99499168
99Amyloidosis (HP:0011034)1.99388300
100Broad metatarsal (HP:0001783)1.98683291
101Protuberant abdomen (HP:0001538)1.96211176
102Autoimmune thrombocytopenia (HP:0001973)1.96092412
103Striae distensae (HP:0001065)1.95888604
104Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.95587240
105* Ovoid vertebral bodies (HP:0003300)1.95423034
106Prolonged neonatal jaundice (HP:0006579)1.94680754
107Short nail (HP:0001799)1.94471081
108Abnormality of fatty-acid metabolism (HP:0004359)1.93669451
109Mitral regurgitation (HP:0001653)1.93275573
110Bone pain (HP:0002653)1.92591548
111Abnormality of purine metabolism (HP:0004352)1.92490185
112Soft skin (HP:0000977)1.92418327
113Abnormality of the acetabulum (HP:0003170)1.91705619
114Elbow flexion contracture (HP:0002987)1.90648386
115Esophageal varix (HP:0002040)1.90067947
116Shallow orbits (HP:0000586)1.89146673
117Nonimmune hydrops fetalis (HP:0001790)1.88765627
118Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.88591378
119Osteolytic defects of the hand bones (HP:0009699)1.88424319
120Osteolytic defects of the phalanges of the hand (HP:0009771)1.88424319
121Conjunctival telangiectasia (HP:0000524)1.87600131
122Hypercholesterolemia (HP:0003124)1.85317182
123Distal lower limb muscle weakness (HP:0009053)1.85103099
124Emphysema (HP:0002097)1.82946407
125Sensorimotor neuropathy (HP:0007141)1.82270141
126Aneurysm (HP:0002617)1.81817312
127Long toe (HP:0010511)1.81770772
128Spontaneous hematomas (HP:0007420)1.79692564
129Aortic regurgitation (HP:0001659)1.79690950
130Gingivitis (HP:0000230)1.79597748
131Hand muscle atrophy (HP:0009130)1.79214637
132Recurrent skin infections (HP:0001581)1.78960527
133Ketoacidosis (HP:0001993)1.78568238
134Coxa vara (HP:0002812)1.78527599
135Generalized amyotrophy (HP:0003700)1.78446783
136Abnormality of iron homeostasis (HP:0011031)1.77831233
137Abnormality of the thoracic spine (HP:0100711)1.76549682
138Increased serum ferritin (HP:0003281)1.76544393
139Flared iliac wings (HP:0002869)1.75865814
140Abnormality of skeletal muscle fiber size (HP:0012084)1.75745108
141Colitis (HP:0002583)1.75519518
142* Joint stiffness (HP:0001387)1.75488609
143Abnormality of sulfur amino acid metabolism (HP:0004339)1.75317345
144Stridor (HP:0010307)1.74987743
145Malnutrition (HP:0004395)1.74774754
146Upper motor neuron abnormality (HP:0002127)1.70233913
147Hypertriglyceridemia (HP:0002155)1.70142192
148Broad face (HP:0000283)1.69428123
149Flat acetabular roof (HP:0003180)1.67347281

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.96482125
2TRIB34.28352736
3PKN23.28974814
4TGFBR23.13341458
5MST1R3.02924759
6PRPF4B2.54574475
7TBK12.41864704
8KIT2.31147650
9TYK22.13987259
10ICK2.13884939
11MAP4K12.10730396
12BLK2.08946601
13SMG12.05796209
14PTK61.92815185
15SIK11.89921872
16BCKDK1.89011419
17TAOK31.86022574
18MAPK151.81906865
19MAP2K31.80084088
20FGFR41.73918844
21TAOK21.64874675
22EPHB11.63852365
23ZAP701.60581187
24TTN1.56005252
25FLT31.55779800
26IRAK31.53336134
27EEF2K1.53026163
28CAMK1D1.50470058
29CDC42BPA1.48606992
30LRRK21.43179831
31JAK11.39370080
32CSF1R1.36592407
33JAK31.34701181
34PRKD21.32201105
35NME21.31502034
36SCYL21.30770165
37MAP3K31.30398759
38MET1.21639101
39RIPK11.21482694
40ARAF1.21480561
41CSK1.19971401
42BMX1.18679899
43MAP3K101.18016391
44PAK41.13292591
45TESK21.12646492
46EPHA21.11131598
47EPHA31.09517913
48KDR1.08687056
49NEK91.08077614
50BTK1.05332618
51JAK21.03335485
52CAMK1G1.02490679
53IKBKE1.00426381
54MYLK0.99028011
55CDK120.96971649
56HCK0.94681738
57IRAK40.93654315
58TAOK10.92283391
59RPS6KA20.91765935
60MAP3K140.89918504
61EPHB20.89504652
62LMTK20.89070511
63PIK3CG0.88062374
64STK100.87125939
65PDGFRA0.87040790
66CAMKK20.84243451
67LIMK10.82098044
68MARK30.81317707
69MAP3K110.80909039
70RIPK40.80788925
71RPS6KA40.78421232
72TESK10.77653659
73SYK0.77482050
74IKBKB0.77332199
75ABL20.73788795
76MAP3K60.73588990
77PAK20.72242612
78LATS20.70718720
79NTRK10.70395950
80PIM20.68307206
81MAPK70.67736764
82PRKD30.65964454
83PTK20.65425265
84MARK20.63832744
85RPS6KL10.63787251
86RPS6KC10.63787251
87CAMKK10.62341335
88BRAF0.62102690
89MAP2K20.61936576
90PRKCH0.61170122
91PDPK10.61060060
92INSRR0.61057700
93MAPKAPK30.60029791
94ITK0.59912927
95RET0.59765018
96MAP3K10.57962010
97LYN0.57844383
98LCK0.57394481
99TGFBR10.56833899
100ILK0.56415387
101PDK20.56191371
102DAPK30.55946059
103DYRK1B0.54494633
104IRAK20.54468852
105GRK70.54253190
106DDR20.54236320
107HIPK20.52460889
108TYRO30.51366390
109TEC0.51089814
110MATK0.51044316
111PDK10.49742522
112IRAK10.49576872
113PRKG20.49147056
114CHUK0.48772599
115GSK3A0.48639834
116MAP3K80.47804634
117TRPM70.47633619
118EGFR0.47165149
119MAPK120.46497201
120MAPKAPK20.43943501
121MAP3K130.43346229
122MAPK40.42860510
123PDGFRB0.42860188
124GRK60.41321526
125KSR20.41215711
126RPS6KA60.40782559
127CDK60.40513692
128STK380.40460017
129MAP3K20.39990016
130ABL10.38488524
131IGF1R0.38237782
132MTOR0.37919670
133MOS0.36223864
134FES0.35379147
135FGFR30.35057650
136MAP3K70.33657436
137MAPK110.32694751
138PIM10.31121529

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.44632839
2* Glycosaminoglycan degradation_Homo sapiens_hsa005313.28851086
3Other glycan degradation_Homo sapiens_hsa005113.16915122
4* Lysosome_Homo sapiens_hsa041422.75182315
5Complement and coagulation cascades_Homo sapiens_hsa046102.68721965
6Primary bile acid biosynthesis_Homo sapiens_hsa001202.48985966
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.35937617
8Pentose and glucuronate interconversions_Homo sapiens_hsa000402.29595517
9Nitrogen metabolism_Homo sapiens_hsa009102.01976613
10Caffeine metabolism_Homo sapiens_hsa002321.98037371
11Fatty acid degradation_Homo sapiens_hsa000711.87416816
12Tryptophan metabolism_Homo sapiens_hsa003801.60882998
13Arginine biosynthesis_Homo sapiens_hsa002201.60067809
14PPAR signaling pathway_Homo sapiens_hsa033201.58720726
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.49671827
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.49248598
17Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.47391649
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.45787296
19Leishmaniasis_Homo sapiens_hsa051401.44689240
20Bladder cancer_Homo sapiens_hsa052191.39130698
21Selenocompound metabolism_Homo sapiens_hsa004501.38274754
22Starch and sucrose metabolism_Homo sapiens_hsa005001.34374652
23Osteoclast differentiation_Homo sapiens_hsa043801.32151011
24Pertussis_Homo sapiens_hsa051331.26749081
25Peroxisome_Homo sapiens_hsa041461.26182689
26Malaria_Homo sapiens_hsa051441.25740264
27Fatty acid metabolism_Homo sapiens_hsa012121.17522820
28Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.17131535
29Histidine metabolism_Homo sapiens_hsa003401.16758260
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.16535420
31Sulfur metabolism_Homo sapiens_hsa009201.16175197
32Vibrio cholerae infection_Homo sapiens_hsa051101.14676249
33Toll-like receptor signaling pathway_Homo sapiens_hsa046201.11773555
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.10077393
35Phagosome_Homo sapiens_hsa041451.06781237
36Sphingolipid metabolism_Homo sapiens_hsa006001.06499042
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.06420699
38ABC transporters_Homo sapiens_hsa020101.05915665
39Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.03314519
40Tyrosine metabolism_Homo sapiens_hsa003501.02980272
41Tuberculosis_Homo sapiens_hsa051521.01781248
42Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.00248872
43Central carbon metabolism in cancer_Homo sapiens_hsa052300.99864730
44Bile secretion_Homo sapiens_hsa049760.98799264
45Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.97309196
46Galactose metabolism_Homo sapiens_hsa000520.97116870
47Butanoate metabolism_Homo sapiens_hsa006500.96704378
48Legionellosis_Homo sapiens_hsa051340.96295084
49Maturity onset diabetes of the young_Homo sapiens_hsa049500.95658730
50Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.95543726
51Notch signaling pathway_Homo sapiens_hsa043300.94730478
52Propanoate metabolism_Homo sapiens_hsa006400.93836295
53Chemical carcinogenesis_Homo sapiens_hsa052040.93493863
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.93218583
55Antigen processing and presentation_Homo sapiens_hsa046120.92893860
56Prion diseases_Homo sapiens_hsa050200.91889447
57beta-Alanine metabolism_Homo sapiens_hsa004100.90658931
58Drug metabolism - other enzymes_Homo sapiens_hsa009830.87116611
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.82894179
60Pentose phosphate pathway_Homo sapiens_hsa000300.82505548
61Toxoplasmosis_Homo sapiens_hsa051450.80146355
62Fat digestion and absorption_Homo sapiens_hsa049750.78197655
63B cell receptor signaling pathway_Homo sapiens_hsa046620.77741115
64Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77109979
65Folate biosynthesis_Homo sapiens_hsa007900.76606152
66Amoebiasis_Homo sapiens_hsa051460.76288228
67Hepatitis C_Homo sapiens_hsa051600.74777087
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.74046619
692-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.74013591
70Proteoglycans in cancer_Homo sapiens_hsa052050.73382022
71Carbon metabolism_Homo sapiens_hsa012000.73162383
72VEGF signaling pathway_Homo sapiens_hsa043700.70736021
73Sulfur relay system_Homo sapiens_hsa041220.68891622
74Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.68849873
75Renin-angiotensin system_Homo sapiens_hsa046140.68594857
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67776191
77N-Glycan biosynthesis_Homo sapiens_hsa005100.67653007
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.67645427
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67505363
80Insulin resistance_Homo sapiens_hsa049310.67119096
81Salmonella infection_Homo sapiens_hsa051320.66727330
82Retinol metabolism_Homo sapiens_hsa008300.66478925
83NF-kappa B signaling pathway_Homo sapiens_hsa040640.63952883
84Pyruvate metabolism_Homo sapiens_hsa006200.63692815
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63537223
86Small cell lung cancer_Homo sapiens_hsa052220.62425980
87Lysine degradation_Homo sapiens_hsa003100.60381179
88Vitamin digestion and absorption_Homo sapiens_hsa049770.59604206
89Chronic myeloid leukemia_Homo sapiens_hsa052200.59013394
90Phenylalanine metabolism_Homo sapiens_hsa003600.58730458
91Rheumatoid arthritis_Homo sapiens_hsa053230.58667610
92Pancreatic cancer_Homo sapiens_hsa052120.57471539
93Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57214433
94Insulin signaling pathway_Homo sapiens_hsa049100.57056701
95Steroid biosynthesis_Homo sapiens_hsa001000.56295314
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55716032
97Glycerolipid metabolism_Homo sapiens_hsa005610.55559994
98Apoptosis_Homo sapiens_hsa042100.55544765
99Protein digestion and absorption_Homo sapiens_hsa049740.55454194
100Biosynthesis of amino acids_Homo sapiens_hsa012300.55225625
101Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.53722851
102AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.53231820
103Measles_Homo sapiens_hsa051620.52340790
104Neurotrophin signaling pathway_Homo sapiens_hsa047220.51225936
105Non-small cell lung cancer_Homo sapiens_hsa052230.50305846
106Prolactin signaling pathway_Homo sapiens_hsa049170.50061110
107Fructose and mannose metabolism_Homo sapiens_hsa000510.49969007
108Hepatitis B_Homo sapiens_hsa051610.49158974
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.48752267
110Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47910187
111Leukocyte transendothelial migration_Homo sapiens_hsa046700.47591713
112AMPK signaling pathway_Homo sapiens_hsa041520.47585345
113Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46614680
114mTOR signaling pathway_Homo sapiens_hsa041500.46608031
115Cyanoamino acid metabolism_Homo sapiens_hsa004600.46002284
116Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.45798461
117ECM-receptor interaction_Homo sapiens_hsa045120.44605400
118TNF signaling pathway_Homo sapiens_hsa046680.44352196
119Endocytosis_Homo sapiens_hsa041440.44232244
120Glutathione metabolism_Homo sapiens_hsa004800.43938509
121Renal cell carcinoma_Homo sapiens_hsa052110.43808582
122Acute myeloid leukemia_Homo sapiens_hsa052210.42572643
123Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42466805
124Vitamin B6 metabolism_Homo sapiens_hsa007500.40252848
125Influenza A_Homo sapiens_hsa051640.39619687
126Endometrial cancer_Homo sapiens_hsa052130.39039835
127Shigellosis_Homo sapiens_hsa051310.38684203
128Focal adhesion_Homo sapiens_hsa045100.37960760
129Arginine and proline metabolism_Homo sapiens_hsa003300.37719819
130Phospholipase D signaling pathway_Homo sapiens_hsa040720.37073369

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