NAGPA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Hydrolases are transported to lysosomes after binding to mannose 6-phosphate receptors in the trans-Golgi network. This gene encodes the enzyme that catalyzes the second step in the formation of the mannose 6-phosphate recognition marker on lysosomal hydrolases. Commonly known as 'uncovering enzyme' or UCE, this enzyme removes N-acetyl-D-glucosamine (GlcNAc) residues from GlcNAc-alpha-P-mannose moieties and thereby produces the recognition marker. The encoded preproprotein is proteolytically processed by furin to generate the mature enzyme, a homotetramer of two disulfide-linked homodimers. Mutations in this gene are associated with developmental stuttering in human patients. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.58319818
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.54330172
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.54330172
4positive regulation by symbiont of host defense response (GO:0052509)4.02372542
5modulation by symbiont of host defense response (GO:0052031)4.02372542
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.02372542
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.02372542
8positive regulation by organism of defense response of other organism involved in symbiotic interact4.02372542
9modulation by symbiont of host immune response (GO:0052553)4.02372542
10antigen processing and presentation of endogenous antigen (GO:0019883)3.97758209
11Arp2/3 complex-mediated actin nucleation (GO:0034314)3.86722916
12regulation of interferon-beta biosynthetic process (GO:0045357)3.80168417
13oligosaccharide catabolic process (GO:0009313)3.74755291
14regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.71327983
15immunoglobulin mediated immune response (GO:0016064)3.67959871
16glycosphingolipid catabolic process (GO:0046479)3.66694286
17DNA deamination (GO:0045006)3.53629035
18neutrophil activation involved in immune response (GO:0002283)3.52272676
19negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.45637638
20negative regulation of cell killing (GO:0031342)3.45637638
21positive regulation of B cell differentiation (GO:0045579)3.41235218
22positive regulation of gamma-delta T cell activation (GO:0046645)3.39256131
23positive regulation of mast cell activation (GO:0033005)3.30281052
24regulation of mast cell degranulation (GO:0043304)3.29425391
25positive regulation of interferon-alpha production (GO:0032727)3.28814633
26glycolipid catabolic process (GO:0019377)3.24795741
27respiratory burst (GO:0045730)3.21532104
28response to peptidoglycan (GO:0032494)3.19738966
29macrophage activation involved in immune response (GO:0002281)3.19318059
30NIK/NF-kappaB signaling (GO:0038061)3.13583634
31amino sugar catabolic process (GO:0046348)3.12602668
32B cell mediated immunity (GO:0019724)3.11616217
33pinocytosis (GO:0006907)3.11472563
34regulation of B cell receptor signaling pathway (GO:0050855)3.11264777
35positive regulation of mast cell activation involved in immune response (GO:0033008)3.10289640
36positive regulation of mast cell degranulation (GO:0043306)3.10289640
37regulation of interferon-alpha production (GO:0032647)3.09664491
38positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.05139220
39ceramide catabolic process (GO:0046514)3.04939344
40pentose-phosphate shunt (GO:0006098)3.02835810
41regulation of mast cell activation involved in immune response (GO:0033006)3.02785181
42regulation of mast cell activation (GO:0033003)3.00426524
43negative regulation of granulocyte differentiation (GO:0030853)2.91099784
44N-acetylneuraminate metabolic process (GO:0006054)2.89918540
45regulation of myeloid leukocyte mediated immunity (GO:0002886)2.89113792
46antigen processing and presentation via MHC class Ib (GO:0002475)2.87700634
47negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.84891053
48mannose metabolic process (GO:0006013)2.83401094
49regulation of B cell differentiation (GO:0045577)2.82695560
50regulation of hypersensitivity (GO:0002883)2.79765858
51negative regulation of interleukin-12 production (GO:0032695)2.79375013
52regulation of superoxide anion generation (GO:0032928)2.79368535
53regulation of leukocyte degranulation (GO:0043300)2.78317676
54actin nucleation (GO:0045010)2.75961973
55negative regulation of phagocytosis (GO:0050765)2.71964698
56positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.71568541
57NADPH regeneration (GO:0006740)2.69009685
58cellular response to thyroid hormone stimulus (GO:0097067)2.66656293
59folic acid-containing compound biosynthetic process (GO:0009396)2.66603288
60negative regulation of interleukin-1 beta production (GO:0032691)2.66321833
61sphingolipid catabolic process (GO:0030149)2.66081725
62regulation of gamma-delta T cell differentiation (GO:0045586)2.65909988
63response to interferon-beta (GO:0035456)2.63303466
64folic acid metabolic process (GO:0046655)2.62518706
65neutrophil mediated immunity (GO:0002446)2.62364793
66* lysosome organization (GO:0007040)2.60738160
67* lytic vacuole organization (GO:0080171)2.60738160
68regulation of cholesterol esterification (GO:0010872)2.60557589
69positive regulation of interferon-beta production (GO:0032728)2.58934064
70cholesterol efflux (GO:0033344)2.58435339
71DNA strand elongation involved in DNA replication (GO:0006271)2.58132912
72positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.56084689
73low-density lipoprotein particle remodeling (GO:0034374)2.55259233
74membrane lipid catabolic process (GO:0046466)2.55068157
75regulation of inflammatory response to antigenic stimulus (GO:0002861)2.54372283
76response to fungus (GO:0009620)2.54249244
77phagosome maturation (GO:0090382)2.52827530
78germinal center formation (GO:0002467)2.51726670
79granulocyte activation (GO:0036230)2.51359150
80negative regulation of cytokine production involved in immune response (GO:0002719)2.51211781
81ribosomal small subunit assembly (GO:0000028)2.51104466
82regulation of gamma-delta T cell activation (GO:0046643)2.50516027
83regulation of macrophage chemotaxis (GO:0010758)2.49545454
84positive regulation of leukocyte degranulation (GO:0043302)2.49076635
85plasma lipoprotein particle clearance (GO:0034381)2.48015551
86negative regulation of interleukin-1 production (GO:0032692)2.47997258
87interferon-gamma-mediated signaling pathway (GO:0060333)2.47050194
88disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.46485020
89killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.46485020
90positive regulation of antigen processing and presentation (GO:0002579)2.45389393
91DNA strand elongation (GO:0022616)2.45197722
92response to muramyl dipeptide (GO:0032495)2.44634351
93response to thyroid hormone (GO:0097066)2.42945185
94regulation of B cell apoptotic process (GO:0002902)2.42751312
95reactive oxygen species biosynthetic process (GO:1903409)2.41807928
96cellular response to interferon-beta (GO:0035458)2.41283681
97myeloid cell activation involved in immune response (GO:0002275)2.41163175
98mature B cell differentiation (GO:0002335)2.40334937
99regulation of regulated secretory pathway (GO:1903305)2.39604706
100regulation of interleukin-12 biosynthetic process (GO:0045075)2.39363550
101response to interferon-alpha (GO:0035455)2.39307066
102production of molecular mediator involved in inflammatory response (GO:0002532)2.38705355
103dendritic cell differentiation (GO:0097028)2.38542272
104viral transcription (GO:0019083)2.38353936
105regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.38194092
106positive regulation of chemokine secretion (GO:0090197)2.37977917
107antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.37315698
108telomere maintenance via semi-conservative replication (GO:0032201)2.36941487
109negative regulation of innate immune response (GO:0045824)2.36372180
110myeloid dendritic cell activation (GO:0001773)2.35848110
111myeloid dendritic cell differentiation (GO:0043011)2.35705120
112cellular response to zinc ion (GO:0071294)2.34817562
113plasma lipoprotein particle assembly (GO:0034377)2.34804812
114response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.34475163
115response to host immune response (GO:0052572)2.34475163
116folic acid transport (GO:0015884)2.34235697
117leukocyte mediated cytotoxicity (GO:0001909)2.33766461
118regulation of type I interferon-mediated signaling pathway (GO:0060338)2.32851567
119positive thymic T cell selection (GO:0045059)2.32333593
120translational termination (GO:0006415)2.31451818
121regulation of T cell tolerance induction (GO:0002664)2.30367927
122B cell receptor signaling pathway (GO:0050853)2.29835291
123T cell apoptotic process (GO:0070231)2.29731107
124positive regulation of B cell mediated immunity (GO:0002714)2.28876446
125positive regulation of immunoglobulin mediated immune response (GO:0002891)2.28876446
126tumor necrosis factor-mediated signaling pathway (GO:0033209)2.28628344
127apoptotic cell clearance (GO:0043277)2.28347549
128negative regulation of T cell mediated immunity (GO:0002710)2.28058152
129defense response to protozoan (GO:0042832)2.26359576
130lipopolysaccharide-mediated signaling pathway (GO:0031663)2.26119778
131positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.25314133
132regulation of T-helper 2 cell differentiation (GO:0045628)2.25284943
133negative regulation of erythrocyte differentiation (GO:0045647)2.25093805
134glycosylceramide metabolic process (GO:0006677)2.24469938
135negative regulation of nitric oxide biosynthetic process (GO:0045019)2.24320031
136regulation of interferon-beta production (GO:0032648)2.22589188
137response to protozoan (GO:0001562)2.22263150
138cellular extravasation (GO:0045123)2.21682149
139formation of translation preinitiation complex (GO:0001731)2.21311237
140antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.21257458
141regulation of antigen processing and presentation (GO:0002577)2.20676570
142regulation of interleukin-8 biosynthetic process (GO:0045414)2.20385544
143regulation of cholesterol storage (GO:0010885)2.20237440
144neutrophil activation (GO:0042119)2.18877316
145nucleobase biosynthetic process (GO:0046112)2.18752132
146negative regulation of myeloid cell apoptotic process (GO:0033033)2.18434377
147positive regulation of lamellipodium assembly (GO:0010592)2.18299461
148hyaluronan catabolic process (GO:0030214)2.17834574
149mature B cell differentiation involved in immune response (GO:0002313)2.17301273
150purine-containing compound salvage (GO:0043101)2.17132229
151negative regulation of growth of symbiont in host (GO:0044130)2.16221796
152negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.16221796
153modulation of growth of symbiont involved in interaction with host (GO:0044144)2.16221796
154regulation of growth of symbiont in host (GO:0044126)2.16221796
155response to type I interferon (GO:0034340)2.16213027
156cellular response to type I interferon (GO:0071357)2.16108539
157type I interferon signaling pathway (GO:0060337)2.16108539
158regulation of protein heterodimerization activity (GO:0043497)2.15725622

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.29196573
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.16409216
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.15677482
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.09752208
5LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.54862636
6THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.51377364
7BP1_19119308_ChIP-ChIP_Hs578T_Human2.43599216
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.40295478
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.33887962
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.32047004
11VDR_21846776_ChIP-Seq_THP-1_Human2.30597633
12MYB_21317192_ChIP-Seq_ERMYB_Mouse2.30439933
13NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.28847946
14SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.28122634
15MYC_22102868_ChIP-Seq_BL_Human2.23554321
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.09387191
17ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.05177846
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.04599590
19IRF8_27001747_Chip-Seq_BMDM_Mouse2.01164247
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.01159634
21NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.00538336
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.94716830
23SPI1_23547873_ChIP-Seq_NB4_Human1.93956801
24FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.86612167
25GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.82633050
26TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.81382885
27VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.79733835
28PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.79296581
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.78234219
30* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.76525516
31KDM2B_26808549_Chip-Seq_SUP-B15_Human1.74145789
32ELF1_17652178_ChIP-ChIP_JURKAT_Human1.72246636
33BCL6_27268052_Chip-Seq_Bcells_Human1.70911401
34MYC_18358816_ChIP-ChIP_MESCs_Mouse1.70297966
35ELF1_20517297_ChIP-Seq_JURKAT_Human1.68160447
36ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.66409609
37SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.65741932
38SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.64421667
39* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.64087604
40SCL_19346495_ChIP-Seq_HPC-7_Human1.63982573
41NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.63234311
42BCOR_27268052_Chip-Seq_Bcells_Human1.62344963
43GATA1_22025678_ChIP-Seq_K562_Human1.59125329
44FOXM1_23109430_ChIP-Seq_U2OS_Human1.58191404
45ETS1_20019798_ChIP-Seq_JURKAT_Human1.58056775
46VDR_24763502_ChIP-Seq_THP-1_Human1.56325462
47MAF_26560356_Chip-Seq_TH1_Human1.54068349
48GATA1_19941827_ChIP-Seq_MEL_Mouse1.54059407
49STAT4_19710469_ChIP-ChIP_TH1__Mouse1.53416164
50GABP_17652178_ChIP-ChIP_JURKAT_Human1.52124372
51RUNX1_22412390_ChIP-Seq_EML_Mouse1.50141915
52P68_20966046_ChIP-Seq_HELA_Human1.49999845
53PPARA_22158963_ChIP-Seq_LIVER_Mouse1.49608245
54MYC_19079543_ChIP-ChIP_MESCs_Mouse1.48420462
55EST1_17652178_ChIP-ChIP_JURKAT_Human1.48092107
56VDR_24787735_ChIP-Seq_THP-1_Human1.47167216
57* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.44417098
58RUNX_20019798_ChIP-Seq_JUKART_Human1.42606031
59IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.42033142
60ERG_20887958_ChIP-Seq_HPC-7_Mouse1.38159589
61RXR_22158963_ChIP-Seq_LIVER_Mouse1.37202331
62STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.36213730
63MYB_26560356_Chip-Seq_TH2_Human1.36194216
64* VDR_23849224_ChIP-Seq_CD4+_Human1.34727479
65GATA1_22383799_ChIP-Seq_G1ME_Mouse1.34462955
66CREB1_15753290_ChIP-ChIP_HEK293T_Human1.34148996
67ELK3_25401928_ChIP-Seq_HUVEC_Human1.34112186
68UTX_26944678_Chip-Seq_JUKART_Human1.33935788
69IKZF1_21737484_ChIP-ChIP_HCT116_Human1.33450434
70E2F4_17652178_ChIP-ChIP_JURKAT_Human1.33201806
71KDM2B_26808549_Chip-Seq_DND41_Human1.32945218
72CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.31887119
73MYB_26560356_Chip-Seq_TH1_Human1.29985263
74* XRN2_22483619_ChIP-Seq_HELA_Human1.29815610
75KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.29533026
76NOTCH1_21737748_ChIP-Seq_TLL_Human1.29290456
77NELFA_20434984_ChIP-Seq_ESCs_Mouse1.29232721
78* TFEB_21752829_ChIP-Seq_HELA_Human1.29011144
79CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28967060
80PU.1_20513432_ChIP-Seq_Bcells_Mouse1.27453351
81FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.26877163
82SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26805505
83MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.26269132
84* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.25560095
85E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.25106790
86PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24539470
87DCP1A_22483619_ChIP-Seq_HELA_Human1.24362730
88E2F1_18555785_ChIP-Seq_MESCs_Mouse1.24018965
89GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23764576
90TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23637698
91RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.22245152
92GATA3_27048872_Chip-Seq_THYMUS_Human1.21508124
93FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.20078518
94TCF7_22412390_ChIP-Seq_EML_Mouse1.20024427
95SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.19730896
96STAT3_1855785_ChIP-Seq_MESCs_Mouse1.19591424
97SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19543834
98CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19276155
99CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.18474288
100FOXP3_21729870_ChIP-Seq_TREG_Human1.18464453
101GATA2_22383799_ChIP-Seq_G1ME_Mouse1.18320183
102STAT1_20625510_ChIP-Seq_HELA_Human1.17995442
103E2F1_20622854_ChIP-Seq_HELA_Human1.17536299
104CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.17533817
105* PHF8_20622854_ChIP-Seq_HELA_Human1.16561037
106HOXB4_20404135_ChIP-ChIP_EML_Mouse1.16228894
107GATA2_21666600_ChIP-Seq_HMVEC_Human1.15549201
108GABP_19822575_ChIP-Seq_HepG2_Human1.14695148
109GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.13986841
110CTCF_27219007_Chip-Seq_ERYTHROID_Human1.13947106
111MAF_26560356_Chip-Seq_TH2_Human1.13042852
112CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13017456
113SPI1_23127762_ChIP-Seq_K562_Human1.12439824
114FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.11903981
115* CIITA_25753668_ChIP-Seq_RAJI_Human1.09966194
116PU_27001747_Chip-Seq_BMDM_Mouse1.09125119
117* CTCF_26484167_Chip-Seq_Bcells_Mouse1.08369064
118STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.06818745
119* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06416781
120GATA1_19941826_ChIP-Seq_K562_Human1.06383098
121TET1_21451524_ChIP-Seq_MESCs_Mouse1.06172423
122PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05737133
123EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.05463171
124LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.05118583
125SPI1_20517297_ChIP-Seq_HL60_Human1.05054401
126* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04275126
127PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03106561
128KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.02889472
129KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.02767729
130SRY_22984422_ChIP-ChIP_TESTIS_Rat1.02665253
131VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.01197423
132SRF_21415370_ChIP-Seq_HL-1_Mouse1.01175639
133SA1_27219007_Chip-Seq_Bcells_Human1.00781633
134SA1_27219007_Chip-Seq_ERYTHROID_Human1.00547514
135LXR_22292898_ChIP-Seq_THP-1_Human1.00097607
136FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.97158627
137STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.96860013
138TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.96501788
139STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.96117722
140CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96105099
141TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95931351
142ZFX_18555785_ChIP-Seq_MESCs_Mouse0.95127375
143Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.94472998

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009840_abnormal_foam_cell3.30839229
2MP0005058_abnormal_lysosome_morphology3.23722214
3MP0001835_abnormal_antigen_presentation3.17082748
4MP0003436_decreased_susceptibility_to3.07702258
5MP0003303_peritoneal_inflammation2.62279280
6MP0003191_abnormal_cellular_cholesterol2.48623169
7MP0002419_abnormal_innate_immunity2.41735722
8MP0009785_altered_susceptibility_to2.24446532
9MP0005000_abnormal_immune_tolerance2.21100121
10MP0005025_abnormal_response_to2.19588532
11MP0006082_CNS_inflammation2.17419417
12MP0000685_abnormal_immune_system2.15643094
13MP0002396_abnormal_hematopoietic_system2.14636013
14MP0002452_abnormal_antigen_presenting2.11896218
15MP0001800_abnormal_humoral_immune2.08998747
16MP0005464_abnormal_platelet_physiology2.07516495
17MP0003724_increased_susceptibility_to2.01139312
18MP0002148_abnormal_hypersensitivity_rea1.99502268
19MP0002723_abnormal_immune_serum1.95459406
20MP0005671_abnormal_response_to1.94225224
21MP0009333_abnormal_splenocyte_physiolog1.89729763
22MP0005387_immune_system_phenotype1.89370206
23MP0001790_abnormal_immune_system1.89370206
24MP0002420_abnormal_adaptive_immunity1.86122531
25MP0001819_abnormal_immune_cell1.85960484
26MP0001853_heart_inflammation1.78138436
27MP0003693_abnormal_embryo_hatching1.77218004
28MP0003195_calcinosis1.74212993
29MP0005167_abnormal_blood-brain_barrier1.68097186
30* MP0003172_abnormal_lysosome_physiology1.67567715
31MP0005397_hematopoietic_system_phenotyp1.67549124
32MP0001545_abnormal_hematopoietic_system1.67549124
33MP0001533_abnormal_skeleton_physiology1.66948335
34MP0002405_respiratory_system_inflammati1.66562710
35MP0000689_abnormal_spleen_morphology1.65326099
36MP0002398_abnormal_bone_marrow1.64131852
37MP0001845_abnormal_inflammatory_respons1.59734710
38MP0000716_abnormal_immune_system1.59062039
39MP0003300_gastrointestinal_ulcer1.58940892
40MP0008469_abnormal_protein_level1.55080387
41MP0002722_abnormal_immune_system1.53677181
42MP0004947_skin_inflammation1.50878450
43MP0000465_gastrointestinal_hemorrhage1.50705167
44MP0010155_abnormal_intestine_physiology1.50623812
45MP0000490_abnormal_crypts_of1.46980619
46MP0002166_altered_tumor_susceptibility1.45787228
47MP0002429_abnormal_blood_cell1.45071608
48MP0004510_myositis1.43138119
49MP0010307_abnormal_tumor_latency1.42904755
50MP0000343_altered_response_to1.41305568
51MP0008260_abnormal_autophagy1.35504034
52MP0003763_abnormal_thymus_physiology1.35028073
53MP0003705_abnormal_hypodermis_morpholog1.32378321
54MP0009278_abnormal_bone_marrow1.31341537
55MP0000858_altered_metastatic_potential1.30944948
56MP0004808_abnormal_hematopoietic_stem1.27054959
57MP0003656_abnormal_erythrocyte_physiolo1.26906634
58MP0003806_abnormal_nucleotide_metabolis1.25811389
59MP0001873_stomach_inflammation1.25038068
60MP0003329_amyloid_beta_deposits1.23933059
61MP0000015_abnormal_ear_pigmentation1.22505329
62MP0010352_gastrointestinal_tract_polyps1.22035423
63MP0003186_abnormal_redox_activity1.20422756
64MP0003690_abnormal_glial_cell1.20238521
65MP0002138_abnormal_hepatobiliary_system1.20057038
66MP0003566_abnormal_cell_adhesion1.19577693
67MP0005451_abnormal_body_composition1.18578839
68MP0003448_altered_tumor_morphology1.14688122
69MP0000609_abnormal_liver_physiology1.12459808
70MP0002006_tumorigenesis1.11783236
71MP0005360_urolithiasis1.09703986
72MP0004957_abnormal_blastocyst_morpholog1.09472974
73MP0009764_decreased_sensitivity_to1.07843766
74MP0003111_abnormal_nucleus_morphology1.05600384
75MP0001986_abnormal_taste_sensitivity1.05486994
76MP0005023_abnormal_wound_healing1.01956644
77MP0008438_abnormal_cutaneous_collagen1.01554371
78MP0003075_altered_response_to1.01387907
79MP0009763_increased_sensitivity_to1.00333165
80MP0002254_reproductive_system_inflammat1.00286151
81MP0005319_abnormal_enzyme/_coenzyme0.99752331
82MP0000604_amyloidosis0.99358019
83MP0006054_spinal_hemorrhage0.99203216
84MP0003879_abnormal_hair_cell0.98411069
85MP0000920_abnormal_myelination0.96674766
86MP0003077_abnormal_cell_cycle0.96633294
87MP0002933_joint_inflammation0.96236543
88MP0000598_abnormal_liver_morphology0.95981339
89MP0002019_abnormal_tumor_incidence0.95303341
90MP0000703_abnormal_thymus_morphology0.95278266
91MP0008875_abnormal_xenobiotic_pharmacok0.92522176
92MP0002139_abnormal_hepatobiliary_system0.91954851
93MP0000371_diluted_coat_color0.91260293
94MP0005075_abnormal_melanosome_morpholog0.90920043
95MP0010094_abnormal_chromosome_stability0.89891461
96MP0005365_abnormal_bile_salt0.89880736
97MP0001501_abnormal_sleep_pattern0.86103846
98MP0001764_abnormal_homeostasis0.85740525
99MP0005647_abnormal_sex_gland0.85730568
100MP0003866_abnormal_defecation0.85605925
101MP0010329_abnormal_lipoprotein_level0.85250730
102MP0008007_abnormal_cellular_replicative0.84058475
103MP0005174_abnormal_tail_pigmentation0.83479198
104MP0005310_abnormal_salivary_gland0.82893896
105MP0005166_decreased_susceptibility_to0.82823660
106MP0003633_abnormal_nervous_system0.82053965
107MP0002693_abnormal_pancreas_physiology0.81589826
108MP0002118_abnormal_lipid_homeostasis0.81351947
109MP0001968_abnormal_touch/_nociception0.81156083
110MP0001851_eye_inflammation0.80727683
111MP0002998_abnormal_bone_remodeling0.79707176
112MP0003183_abnormal_peptide_metabolism0.79279772
113MP0005165_increased_susceptibility_to0.78274183
114MP0005076_abnormal_cell_differentiation0.78099663
115MP0002653_abnormal_ependyma_morphology0.78094934
116MP0005390_skeleton_phenotype0.77915258
117MP0009643_abnormal_urine_homeostasis0.77900102
118MP0008873_increased_physiological_sensi0.77808562
119MP0005670_abnormal_white_adipose0.77542257
120MP0001663_abnormal_digestive_system0.75967731
121MP0002064_seizures0.75617073
122MP0000249_abnormal_blood_vessel0.74583969
123MP0001915_intracranial_hemorrhage0.74028764
124MP0000313_abnormal_cell_death0.73195054
125MP0003828_pulmonary_edema0.72068712
126MP0008874_decreased_physiological_sensi0.69661971
127MP0008004_abnormal_stomach_pH0.66492241
128MP0005164_abnormal_response_to0.61967706
129MP0005584_abnormal_enzyme/coenzyme_acti0.61729474
130MP0003795_abnormal_bone_structure0.57724622
131MP0009642_abnormal_blood_homeostasis0.55097497

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)4.70741161
2Eczematoid dermatitis (HP:0000976)4.44048618
3Recurrent bacterial skin infections (HP:0005406)4.28094787
4Systemic lupus erythematosus (HP:0002725)4.14301366
5Vacuolated lymphocytes (HP:0001922)4.07024042
6Dysostosis multiplex (HP:0000943)3.82875541
7Recurrent gram-negative bacterial infections (HP:0005420)3.75869372
8Abnormality of macrophages (HP:0004311)3.65818879
9Stomatitis (HP:0010280)3.65723022
10IgM deficiency (HP:0002850)3.51013910
11Elevated erythrocyte sedimentation rate (HP:0003565)3.42577854
12Increased cerebral lipofuscin (HP:0011813)3.42491485
13Thrombocytosis (HP:0001894)3.23098150
14Mutism (HP:0002300)3.21488173
15Purpura (HP:0000979)3.15453205
16Chronic otitis media (HP:0000389)3.14169797
17Glomerulonephritis (HP:0000099)3.07488316
18Increased neuronal autofluorescent lipopigment (HP:0002074)3.06863242
19Mucopolysacchariduria (HP:0008155)3.03320662
20Urinary glycosaminoglycan excretion (HP:0003541)3.03320662
21Abnormality of liposaccharide metabolism (HP:0010968)2.96290217
22Abnormality of glycosphingolipid metabolism (HP:0004343)2.96290217
23Abnormality of glycolipid metabolism (HP:0010969)2.96290217
24Recurrent skin infections (HP:0001581)2.94134924
25Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.89694361
26Amyloidosis (HP:0011034)2.88013465
27Myositis (HP:0100614)2.85348391
28Petechiae (HP:0000967)2.85062878
29Retrobulbar optic neuritis (HP:0100654)2.83478944
30Optic neuritis (HP:0100653)2.83478944
31Recurrent fungal infections (HP:0002841)2.80663495
32Abnormality of polysaccharide metabolism (HP:0011012)2.75550246
33Abnormality of glycosaminoglycan metabolism (HP:0004371)2.75550246
34Abnormality of mucopolysaccharide metabolism (HP:0011020)2.75550246
35Recurrent viral infections (HP:0004429)2.73953465
36Pustule (HP:0200039)2.69429808
37Cellulitis (HP:0100658)2.65885836
38Axonal loss (HP:0003447)2.62707288
39Abnormality of complement system (HP:0005339)2.59984898
40Agnosia (HP:0010524)2.58697649
41Mediastinal lymphadenopathy (HP:0100721)2.58135599
42Periodontitis (HP:0000704)2.55235537
43Complement deficiency (HP:0004431)2.53825505
44Chronic obstructive pulmonary disease (HP:0006510)2.53530389
45Obstructive lung disease (HP:0006536)2.53530389
46Pulmonary infiltrates (HP:0002113)2.47344137
47Autoimmune thrombocytopenia (HP:0001973)2.44586478
48Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.40263514
49Loss of speech (HP:0002371)2.40010740
50Epistaxis (HP:0000421)2.39233597
51Interstitial pulmonary disease (HP:0006530)2.36007684
52Increased serum ferritin (HP:0003281)2.35654684
53Abnormality of T cell physiology (HP:0011840)2.33806054
54Neuronal loss in central nervous system (HP:0002529)2.33267119
55Prolonged neonatal jaundice (HP:0006579)2.32900287
56Spontaneous hematomas (HP:0007420)2.30071070
57Impaired platelet aggregation (HP:0003540)2.27174376
58Abnormal platelet function (HP:0011869)2.27174376
59Episodic fever (HP:0001954)2.24727998
60Abnormality of the nasal mucosa (HP:0000433)2.24662349
61Gastrointestinal inflammation (HP:0004386)2.23444336
62Myocardial infarction (HP:0001658)2.23015817
63Colitis (HP:0002583)2.22438966
64Reduced antithrombin III activity (HP:0001976)2.21663434
65Albinism (HP:0001022)2.21258544
66Inflammation of the large intestine (HP:0002037)2.21093287
67Nasal polyposis (HP:0100582)2.20711453
68Hepatosplenomegaly (HP:0001433)2.19187535
69Thoracic kyphosis (HP:0002942)2.18207633
70Keratoconjunctivitis (HP:0001096)2.16602068
71Keratoconjunctivitis sicca (HP:0001097)2.16529069
72Global brain atrophy (HP:0002283)2.14981590
73Abnormality of the vasculature of the conjunctiva (HP:0008054)2.14570638
74Urticaria (HP:0001025)2.13495529
75Diminished motivation (HP:0000745)2.13210126
76Gingivitis (HP:0000230)2.13176157
77Neurofibrillary tangles (HP:0002185)2.12603382
78Disinhibition (HP:0000734)2.12589777
79Osteolytic defects of the phalanges of the hand (HP:0009771)2.12271824
80Osteolytic defects of the hand bones (HP:0009699)2.12271824
81Meningitis (HP:0001287)2.11489578
82Apathy (HP:0000741)2.11444086
83Hemoptysis (HP:0002105)2.10462014
84Abnormality of iron homeostasis (HP:0011031)2.05417882
85Gingival bleeding (HP:0000225)2.05405636
86Recurrent bronchitis (HP:0002837)2.04982596
87Prolonged bleeding time (HP:0003010)2.04483006
88Abnormal number of erythroid precursors (HP:0012131)2.04403669
89Metaphyseal irregularity (HP:0003025)2.02903234
90Asymmetric septal hypertrophy (HP:0001670)2.01901015
91Basal ganglia calcification (HP:0002135)2.01492307
92Personality changes (HP:0000751)2.00464511
93Poor head control (HP:0002421)2.00278631
94Hematochezia (HP:0002573)1.99208345
95Deep venous thrombosis (HP:0002625)1.98793212
96Abnormality of cells of the erythroid lineage (HP:0012130)1.97646540
97Xanthomatosis (HP:0000991)1.97560246
98Vasculitis (HP:0002633)1.97020466
99Visual hallucinations (HP:0002367)1.96979923
100Leukocytosis (HP:0001974)1.96082121
101Chronic mucocutaneous candidiasis (HP:0002728)1.95901527
102Recurrent cutaneous fungal infections (HP:0011370)1.95901527
103Joint stiffness (HP:0001387)1.95713933
104Joint hemorrhage (HP:0005261)1.92931441
105Dementia (HP:0000726)1.92816007
106Supranuclear gaze palsy (HP:0000605)1.92517823
107Abnormality of the periventricular white matter (HP:0002518)1.91957055
108Abnormality of T cells (HP:0002843)1.90423911
109Osteomyelitis (HP:0002754)1.90262570
110Retinal atrophy (HP:0001105)1.89621770
111Conjunctival telangiectasia (HP:0000524)1.89606439
112Granulocytopenia (HP:0001913)1.89184204
113Abnormality of transition element cation homeostasis (HP:0011030)1.89053704
114Progressive neurologic deterioration (HP:0002344)1.89038122
115Pathologic fracture (HP:0002756)1.89001263
116Nausea (HP:0002018)1.88513705
117Panhypogammaglobulinemia (HP:0003139)1.88178123
118Increased IgM level (HP:0003496)1.88172191
119Orchitis (HP:0100796)1.87799273
120J-shaped sella turcica (HP:0002680)1.87484805
121Mesangial abnormality (HP:0001966)1.86667406
122Nephritis (HP:0000123)1.85115679
123Nonimmune hydrops fetalis (HP:0001790)1.85043193
124Progressive visual loss (HP:0000529)1.83415717
125Cervical subluxation (HP:0003308)1.82936489
126Upper motor neuron abnormality (HP:0002127)1.82838850
127Eosinophilia (HP:0001880)1.82145298
128Abnormality of the thoracic spine (HP:0100711)1.81791881
129Abnormal delayed hypersensitivity skin test (HP:0002963)1.81481111
130Vertebral compression fractures (HP:0002953)1.80595897
131Encephalitis (HP:0002383)1.79126907
132Hemorrhage of the eye (HP:0011885)1.79060769
133Polyneuropathy (HP:0001271)1.77452254
134Chest pain (HP:0100749)1.75551419
135Abnormality of the pleura (HP:0002103)1.75211026
136Nuclear cataract (HP:0100018)1.72206006
137Progressive microcephaly (HP:0000253)1.70188151
138Memory impairment (HP:0002354)1.69428558
139Ocular albinism (HP:0001107)1.68251516
140Pulmonary embolism (HP:0002204)1.67184106
141Abnormality of lateral ventricle (HP:0030047)1.66872329
142Gastrointestinal infarctions (HP:0005244)1.66506898

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.61547851
2ERN13.29658485
3BLK2.87744918
4TBK12.30816443
5KDR2.24434346
6NME22.23522143
7TYK22.22281777
8TGFBR22.22167754
9IRAK42.21840025
10PKN22.21479195
11KIT2.20404428
12TRIB32.15028526
13SCYL22.08022984
14IRAK32.04694284
15TESK21.97233743
16ZAP701.90665905
17CSF1R1.87622692
18STK101.85726873
19PIM21.77517087
20MAP2K31.75632758
21DAPK21.73410535
22FLT31.73295147
23WEE11.67494967
24BTK1.66467693
25RPS6KA41.66358541
26MAP3K131.62285258
27TIE11.61357159
28EEF2K1.60802858
29JAK31.53325532
30PRPF4B1.53129742
31BCKDK1.51702063
32EIF2AK11.50796269
33TNK21.43082007
34NEK21.41976909
35LRRK21.41607361
36TEC1.40979236
37MAP3K111.39525041
38SIK21.39300451
39GRK71.38752318
40PAK41.37316500
41ADRBK21.35646173
42FRK1.34611194
43BUB11.32430223
44EIF2AK31.31817536
45MAP3K101.30628266
46TAOK21.29703775
47FGR1.21726077
48PRKD21.17536457
49IKBKE1.16219713
50SYK1.14641703
51MAP2K61.14401292
52STK161.13371894
53RIPK41.10738962
54IKBKB1.10101524
55ACVR1B1.07479352
56TAOK31.04115967
57TSSK60.98959684
58PIM10.98193712
59CSK0.98091889
60PDPK10.97801289
61GRK10.97645495
62TTN0.97524342
63MAP3K80.95505968
64CDC42BPA0.93027152
65DAPK10.92261712
66MAP3K30.92132784
67PDK10.90960937
68LYN0.89903342
69MAP3K10.89270539
70GRK60.88713569
71MAP3K140.88440625
72HCK0.87084721
73LCK0.86075514
74JAK10.83520129
75PASK0.82884219
76SIK30.81393611
77RPS6KB20.81104367
78PAK60.80942220
79CDK40.80207039
80ITK0.79298869
81MAPKAPK30.78546130
82TXK0.77644609
83BMPR20.77469501
84CAMKK20.76363450
85MATK0.75906535
86ABL20.74052992
87EPHA20.72766411
88JAK20.72023350
89FES0.71894091
90SIK10.71847772
91TGFBR10.71320069
92EPHB10.71005921
93MAPK120.69672000
94CDK70.64831500
95TESK10.63938977
96NEK90.63333718
97CLK10.62154990
98MAP2K20.61853659
99CDC70.59565609
100FGFR40.59094326
101MARK20.58489718
102CAMK1D0.58343653
103STK40.57649452
104PRKG20.56245216
105IRAK20.55773936
106STK380.55258875
107CDK120.53222742
108MAPK40.52959626
109RPS6KA20.52432214
110PTK60.51120394
111PRKCQ0.49928215
112CAMKK10.49920822
113BRSK20.49335072
114MARK30.48800345
115CHUK0.48291934
116TLK10.46271201
117BMX0.45548611
118FGFR30.45478368
119NTRK30.45382542
120CAMK40.45049898
121PTK2B0.45000626
122CDK60.44151403
123MAPK110.44010740
124ICK0.43574668
125TYRO30.43383012
126VRK10.42263576
127MAPKAPK20.42008070
128MAP4K20.40966652
129DYRK30.40110209
130ATR0.40029763
131HIPK20.39368520
132PAK10.39214688
133ARAF0.38506828
134RPS6KA60.37864464
135MOS0.37694212
136PINK10.37588125
137DAPK30.37306077
138PRKAA20.37210032
139RPS6KL10.37178972
140RPS6KC10.37178972
141MAP3K50.37151812
142ABL10.37062435
143DDR20.36374407
144NLK0.32792643
145EIF2AK20.31674631
146TAOK10.31412682

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051502.84825517
2DNA replication_Homo sapiens_hsa030302.72897895
3Allograft rejection_Homo sapiens_hsa053302.57194737
4Glycosaminoglycan degradation_Homo sapiens_hsa005312.49214793
5Other glycan degradation_Homo sapiens_hsa005112.43190162
6Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.28249924
7Rheumatoid arthritis_Homo sapiens_hsa053232.20893148
8Leishmaniasis_Homo sapiens_hsa051402.19019583
9Autoimmune thyroid disease_Homo sapiens_hsa053202.18945787
10Graft-versus-host disease_Homo sapiens_hsa053322.13537220
11Type I diabetes mellitus_Homo sapiens_hsa049402.12185170
12* Lysosome_Homo sapiens_hsa041422.00402428
13Ribosome_Homo sapiens_hsa030101.90188335
14Antigen processing and presentation_Homo sapiens_hsa046121.89652689
15One carbon pool by folate_Homo sapiens_hsa006701.79618810
16Legionellosis_Homo sapiens_hsa051341.74502737
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.69516486
18Proteasome_Homo sapiens_hsa030501.67865554
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.67214449
20Pentose phosphate pathway_Homo sapiens_hsa000301.65238408
21Mismatch repair_Homo sapiens_hsa034301.59218512
22Base excision repair_Homo sapiens_hsa034101.57889983
23Osteoclast differentiation_Homo sapiens_hsa043801.56443745
24Collecting duct acid secretion_Homo sapiens_hsa049661.55474156
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.49178666
26Folate biosynthesis_Homo sapiens_hsa007901.48888227
27Primary immunodeficiency_Homo sapiens_hsa053401.47409786
28Pertussis_Homo sapiens_hsa051331.46433537
29B cell receptor signaling pathway_Homo sapiens_hsa046621.42949558
30Caffeine metabolism_Homo sapiens_hsa002321.41236248
31Toll-like receptor signaling pathway_Homo sapiens_hsa046201.37865713
32Sulfur relay system_Homo sapiens_hsa041221.35236236
33Complement and coagulation cascades_Homo sapiens_hsa046101.34567476
34Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.32872243
35Measles_Homo sapiens_hsa051621.32551611
36RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.29413929
37Tuberculosis_Homo sapiens_hsa051521.23733035
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.22446797
39Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.21083236
40Pentose and glucuronate interconversions_Homo sapiens_hsa000401.20383423
41Herpes simplex infection_Homo sapiens_hsa051681.20311288
42Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.20298278
43Drug metabolism - other enzymes_Homo sapiens_hsa009831.15920301
44Malaria_Homo sapiens_hsa051441.15688908
45Sphingolipid metabolism_Homo sapiens_hsa006001.14555709
46Selenocompound metabolism_Homo sapiens_hsa004501.12567427
47Pyrimidine metabolism_Homo sapiens_hsa002401.12561179
48Apoptosis_Homo sapiens_hsa042101.11627309
49Shigellosis_Homo sapiens_hsa051311.08449476
50Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.07735359
51Primary bile acid biosynthesis_Homo sapiens_hsa001201.05621222
52Synaptic vesicle cycle_Homo sapiens_hsa047211.05576063
53Intestinal immune network for IgA production_Homo sapiens_hsa046721.03828287
54SNARE interactions in vesicular transport_Homo sapiens_hsa041301.01292184
55Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.00844178
56Renin-angiotensin system_Homo sapiens_hsa046141.00047572
57NOD-like receptor signaling pathway_Homo sapiens_hsa046210.99756656
58Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.97173809
59Sulfur metabolism_Homo sapiens_hsa009200.94722582
60Spliceosome_Homo sapiens_hsa030400.94348297
61Influenza A_Homo sapiens_hsa051640.93675114
62Homologous recombination_Homo sapiens_hsa034400.93267028
63Toxoplasmosis_Homo sapiens_hsa051450.91238475
64Hematopoietic cell lineage_Homo sapiens_hsa046400.91108179
65Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.90876140
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.87319596
67Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.86041735
68Acute myeloid leukemia_Homo sapiens_hsa052210.85677767
69Galactose metabolism_Homo sapiens_hsa000520.85601784
70Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.82774461
71Epstein-Barr virus infection_Homo sapiens_hsa051690.82766690
72Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.82613807
73Nucleotide excision repair_Homo sapiens_hsa034200.81868223
74RNA polymerase_Homo sapiens_hsa030200.80987570
75T cell receptor signaling pathway_Homo sapiens_hsa046600.80761507
76African trypanosomiasis_Homo sapiens_hsa051430.80335975
77Phagosome_Homo sapiens_hsa041450.79373504
78Chemokine signaling pathway_Homo sapiens_hsa040620.77700532
79Biosynthesis of amino acids_Homo sapiens_hsa012300.77597865
80Carbon metabolism_Homo sapiens_hsa012000.74995952
81Jak-STAT signaling pathway_Homo sapiens_hsa046300.74174042
82N-Glycan biosynthesis_Homo sapiens_hsa005100.74111857
83Salmonella infection_Homo sapiens_hsa051320.73707347
84Leukocyte transendothelial migration_Homo sapiens_hsa046700.73675258
852-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.72325039
86Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.72152855
87p53 signaling pathway_Homo sapiens_hsa041150.71820417
88RNA transport_Homo sapiens_hsa030130.71394136
89Vibrio cholerae infection_Homo sapiens_hsa051100.71030869
90Hepatitis B_Homo sapiens_hsa051610.70506997
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69604599
92Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68792370
93Cysteine and methionine metabolism_Homo sapiens_hsa002700.67520378
94Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67191137
95Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.65024932
96Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64081423
97Nitrogen metabolism_Homo sapiens_hsa009100.62451848
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.62029279
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.59859600
100Viral carcinogenesis_Homo sapiens_hsa052030.59010690
101Systemic lupus erythematosus_Homo sapiens_hsa053220.58927131
102TNF signaling pathway_Homo sapiens_hsa046680.57516528
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.57321009
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.54317567
105Glutathione metabolism_Homo sapiens_hsa004800.52595390
106Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51859130
107Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.51520248
108PPAR signaling pathway_Homo sapiens_hsa033200.51163185
109Ether lipid metabolism_Homo sapiens_hsa005650.50988839
110Fructose and mannose metabolism_Homo sapiens_hsa000510.50931738
111Chronic myeloid leukemia_Homo sapiens_hsa052200.49722680
112Asthma_Homo sapiens_hsa053100.49643619
113Cell cycle_Homo sapiens_hsa041100.49371225
114Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.48657357
115Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47787245
116Mineral absorption_Homo sapiens_hsa049780.47364663
117Viral myocarditis_Homo sapiens_hsa054160.46866360
118Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46313602
119ABC transporters_Homo sapiens_hsa020100.44942425
120Fatty acid degradation_Homo sapiens_hsa000710.44284561
121Vitamin B6 metabolism_Homo sapiens_hsa007500.43938617
122Small cell lung cancer_Homo sapiens_hsa052220.43931075
123Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43294117
124Tryptophan metabolism_Homo sapiens_hsa003800.42945870
125Peroxisome_Homo sapiens_hsa041460.40995509
126Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40846078
127AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.40767778
128Prion diseases_Homo sapiens_hsa050200.39603061
129Regulation of autophagy_Homo sapiens_hsa041400.38859249
130Starch and sucrose metabolism_Homo sapiens_hsa005000.38771998
131Arachidonic acid metabolism_Homo sapiens_hsa005900.38722488
132Hepatitis C_Homo sapiens_hsa051600.38376909
133Platelet activation_Homo sapiens_hsa046110.36963456
134VEGF signaling pathway_Homo sapiens_hsa043700.35468313
135Glycerolipid metabolism_Homo sapiens_hsa005610.35083294
136Endocytosis_Homo sapiens_hsa041440.34910259
137Insulin resistance_Homo sapiens_hsa049310.25950152
138Aldosterone synthesis and secretion_Homo sapiens_hsa049250.24533761
139Histidine metabolism_Homo sapiens_hsa003400.24160088
140Carbohydrate digestion and absorption_Homo sapiens_hsa049730.23464328
141Cyanoamino acid metabolism_Homo sapiens_hsa004600.23215060
142Phosphatidylinositol signaling system_Homo sapiens_hsa040700.19778767

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