NAIF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)9.10856867
2response to growth hormone (GO:0060416)8.40279233
3regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)7.66509331
4JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)7.51501189
5positive regulation of receptor internalization (GO:0002092)7.11429778
6positive regulation by symbiont of host defense response (GO:0052509)7.10415889
7modulation by symbiont of host defense response (GO:0052031)7.10415889
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:007.10415889
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:07.10415889
10positive regulation by organism of defense response of other organism involved in symbiotic interact7.10415889
11modulation by symbiont of host immune response (GO:0052553)7.10415889
12regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)6.30438534
13macrophage activation involved in immune response (GO:0002281)5.74746887
14detection of molecule of bacterial origin (GO:0032490)5.59700235
15positive regulation of tyrosine phosphorylation of Stat3 protein (GO:0042517)5.28019983
16microglial cell activation (GO:0001774)5.15960529
17regulation of interleukin-6 biosynthetic process (GO:0045408)5.06550284
18anatomical structure maturation (GO:0071695)4.96041644
19T-helper 1 type immune response (GO:0042088)4.86259911
20response to host immune response (GO:0052572)4.61002283
21response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.61002283
22DNA deamination (GO:0045006)4.50158593
23regulation of receptor internalization (GO:0002090)4.41918748
24regulation of tyrosine phosphorylation of Stat3 protein (GO:0042516)4.18986454
25response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.10938700
26response to host (GO:0075136)4.10938700
27response to host defenses (GO:0052200)4.10938700
28positive regulation of multicellular organism growth (GO:0040018)4.07442072
29JAK-STAT cascade (GO:0007259)3.96321247
30dendritic spine morphogenesis (GO:0060997)3.79372817
31cellular response to interleukin-15 (GO:0071350)3.72359511
32striated muscle atrophy (GO:0014891)3.64378096
33protein prenylation (GO:0018342)3.61048212
34prenylation (GO:0097354)3.61048212
35detection of external biotic stimulus (GO:0098581)3.58690751
36positive regulation of mast cell activation involved in immune response (GO:0033008)3.52003888
37positive regulation of mast cell degranulation (GO:0043306)3.52003888
38macrophage activation (GO:0042116)3.51544988
39righting reflex (GO:0060013)3.45790191
40protein localization to chromosome, centromeric region (GO:0071459)3.41895854
41ribosomal small subunit assembly (GO:0000028)3.38903873
42positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531)3.38223165
43hepatocyte apoptotic process (GO:0097284)3.36061851
44positive regulation of mast cell activation (GO:0033005)3.35196247
45positive regulation of receptor-mediated endocytosis (GO:0048260)3.34298207
46antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.23048995
47antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.23048995
48response to interleukin-15 (GO:0070672)3.21554528
49positive regulation of bone resorption (GO:0045780)3.21397639
50positive regulation of bone remodeling (GO:0046852)3.21397639
51mitotic sister chromatid segregation (GO:0000070)3.21064561
52DNA strand elongation involved in DNA replication (GO:0006271)3.16657491
53mitotic metaphase plate congression (GO:0007080)3.13340719
54detection of biotic stimulus (GO:0009595)3.10056188
55kinetochore organization (GO:0051383)3.09366123
56mitotic nuclear envelope disassembly (GO:0007077)3.08150528
57telomere maintenance via semi-conservative replication (GO:0032201)3.07210294
58regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.05062716
59muscle atrophy (GO:0014889)3.02714917
60nuclear pore complex assembly (GO:0051292)3.02712957
61DNA strand elongation (GO:0022616)3.02336402
62kinetochore assembly (GO:0051382)2.97622808
63positive regulation of phosphatidylinositol 3-kinase signaling (GO:0014068)2.97353843
64regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.94744864
65antigen processing and presentation of endogenous antigen (GO:0019883)2.92361584
66skeletal muscle adaptation (GO:0043501)2.91752553
67regulation of interferon-beta biosynthetic process (GO:0045357)2.89608072
68oxidative demethylation (GO:0070989)2.82227761
69regulation of superoxide anion generation (GO:0032928)2.81867432
70telomere maintenance via recombination (GO:0000722)2.81657660
71labyrinthine layer development (GO:0060711)2.81296880
72regulation of tyrosine phosphorylation of STAT protein (GO:0042509)2.81243393
73natural killer cell mediated cytotoxicity (GO:0042267)2.79668578
74natural killer cell mediated immunity (GO:0002228)2.79668578
75folic acid-containing compound biosynthetic process (GO:0009396)2.78355657
76regulation of gamma-delta T cell differentiation (GO:0045586)2.78034977
77positive regulation of leukocyte degranulation (GO:0043302)2.77769499
78interferon-gamma secretion (GO:0072643)2.76615051
79positive regulation of JAK-STAT cascade (GO:0046427)2.75750637
80Arp2/3 complex-mediated actin nucleation (GO:0034314)2.74891987
81nuclear pore organization (GO:0006999)2.74371249
82preassembly of GPI anchor in ER membrane (GO:0016254)2.74287327
83nuclear envelope disassembly (GO:0051081)2.73881466
84membrane disassembly (GO:0030397)2.73881466
85CENP-A containing nucleosome assembly (GO:0034080)2.72091381
86response to muramyl dipeptide (GO:0032495)2.70900386
87sperm-egg recognition (GO:0035036)2.69557150
88DNA replication initiation (GO:0006270)2.69516347
89establishment of chromosome localization (GO:0051303)2.69286562
90ribosome biogenesis (GO:0042254)2.68805669
91L-fucose catabolic process (GO:0042355)2.68506995
92fucose catabolic process (GO:0019317)2.68506995
93L-fucose metabolic process (GO:0042354)2.68506995
94regulation of spindle organization (GO:0090224)2.68154842
95sister chromatid segregation (GO:0000819)2.67025495
96cilium or flagellum-dependent cell motility (GO:0001539)2.66211003
97positive regulation of regulated secretory pathway (GO:1903307)2.65971065
98IMP biosynthetic process (GO:0006188)2.64498774
99chromatin remodeling at centromere (GO:0031055)2.63908918
100binding of sperm to zona pellucida (GO:0007339)2.63305125
101NIK/NF-kappaB signaling (GO:0038061)2.62605740
102metaphase plate congression (GO:0051310)2.60167199
103neutrophil activation involved in immune response (GO:0002283)2.59274300
104negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.57349746
105negative regulation of translation, ncRNA-mediated (GO:0040033)2.57349746
106regulation of translation, ncRNA-mediated (GO:0045974)2.57349746
107histone exchange (GO:0043486)2.57348962
108proteasome assembly (GO:0043248)2.57082740
109regulation of spindle checkpoint (GO:0090231)2.56036794
110single strand break repair (GO:0000012)2.55986302
111pinocytosis (GO:0006907)2.54547807
112pore complex assembly (GO:0046931)2.53927677
113hydrogen peroxide biosynthetic process (GO:0050665)2.52995868
114protein localization to kinetochore (GO:0034501)2.52619387
115myeloid cell activation involved in immune response (GO:0002275)2.52093225
116cell-cell recognition (GO:0009988)2.51790711
117regulation of gamma-delta T cell activation (GO:0046643)2.51360264
118antigen processing and presentation via MHC class Ib (GO:0002475)2.51145983
119mitotic recombination (GO:0006312)2.50183436
120negative regulation of T cell mediated immunity (GO:0002710)2.49958864
121regulation of platelet aggregation (GO:0090330)2.49037766
122antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.47966662
123positive regulation of interleukin-1 beta secretion (GO:0050718)2.47219506
124negative regulation of cAMP-mediated signaling (GO:0043951)2.46490878
125intestinal absorption (GO:0050892)2.45972253
126coenzyme A biosynthetic process (GO:0015937)2.45184502
127nucleobase biosynthetic process (GO:0046112)2.44712031
128DNA replication-independent nucleosome organization (GO:0034724)2.44313820
129DNA replication-independent nucleosome assembly (GO:0006336)2.44313820
130regulation of mast cell degranulation (GO:0043304)2.43653824
131immunoglobulin mediated immune response (GO:0016064)2.43303321
132reactive oxygen species biosynthetic process (GO:1903409)2.42107164
133microtubule depolymerization (GO:0007019)2.41310991
134positive regulation of gamma-delta T cell activation (GO:0046645)2.40642829
135positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.40635268
136regulation of mitotic spindle checkpoint (GO:1903504)2.39980608
137regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.39980608
138fusion of sperm to egg plasma membrane (GO:0007342)2.39558761
139DNA packaging (GO:0006323)2.39289828
140DNA replication checkpoint (GO:0000076)2.39072973
1413-UTR-mediated mRNA stabilization (GO:0070935)2.38374255
142purine nucleobase biosynthetic process (GO:0009113)2.38374092
143cellular extravasation (GO:0045123)2.37974130
144chromosome condensation (GO:0030261)2.37603013
145deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.36531642
146skeletal muscle tissue regeneration (GO:0043403)2.36427406
147male meiosis I (GO:0007141)2.35242209
148negative regulation of platelet activation (GO:0010544)2.35120229
149regulation of platelet activation (GO:0010543)2.34544724
150negative regulation of actin filament bundle assembly (GO:0032232)2.34460786
151regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.34354401
152motile cilium assembly (GO:0044458)2.32697498
153negative regulation of T cell receptor signaling pathway (GO:0050860)2.32062596
154neural tube formation (GO:0001841)2.31643338
155modulation by symbiont of host cellular process (GO:0044068)2.31581273
156IMP metabolic process (GO:0046040)2.30753690
157negative regulation of interleukin-1 production (GO:0032692)2.30733322
158positive regulation of interleukin-1 secretion (GO:0050716)2.29859619
159sperm motility (GO:0030317)2.29421186
160regulation of mast cell activation (GO:0033003)2.28090658
161positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.27850769
162regulation of centrosome cycle (GO:0046605)2.27785838
163negative regulation of Rho protein signal transduction (GO:0035024)2.26840965
164B cell mediated immunity (GO:0019724)2.26654836
165T cell apoptotic process (GO:0070231)2.26326294
166ribonucleoprotein complex biogenesis (GO:0022613)2.25900634
167positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.25237148
168positive regulation of chromosome segregation (GO:0051984)2.24334891
169DNA replication-dependent nucleosome assembly (GO:0006335)2.21698877
170DNA replication-dependent nucleosome organization (GO:0034723)2.21698877
171regulation of RIG-I signaling pathway (GO:0039535)2.21353917
172meiotic chromosome segregation (GO:0045132)2.20837438
173axonemal dynein complex assembly (GO:0070286)2.20702951
174regulation of double-strand break repair via homologous recombination (GO:0010569)2.20150278
175modulation by virus of host process (GO:0019054)2.18805431
176spermatid development (GO:0007286)2.17156414
177ribosomal small subunit biogenesis (GO:0042274)2.16460331
178regulation of mitotic spindle organization (GO:0060236)2.13940326
179regulation of centriole replication (GO:0046599)2.13912563
180telomere maintenance via telomere lengthening (GO:0010833)2.13331460
181response to interferon-beta (GO:0035456)2.13318482
182DNA unwinding involved in DNA replication (GO:0006268)2.13107947
183nucleotide-excision repair, DNA gap filling (GO:0006297)2.13036303
184cellular response to zinc ion (GO:0071294)2.12284065
185positive regulation of mitotic sister chromatid separation (GO:1901970)2.11535277
186positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.11535277
187positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.11535277
188translesion synthesis (GO:0019985)2.11388122
189formation of translation preinitiation complex (GO:0001731)2.11092811
190regulation of activation of Janus kinase activity (GO:0010533)18.0592522
191growth hormone receptor signaling pathway (GO:0060396)17.3188616
192cellular response to growth hormone stimulus (GO:0071378)15.3796565
193positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)10.1606889

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.92370167
2VDR_22108803_ChIP-Seq_LS180_Human4.84873903
3RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.17386725
4FOXM1_23109430_ChIP-Seq_U2OS_Human4.14910453
5CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human3.95049978
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.79124211
7STAT6_21828071_ChIP-Seq_BEAS2B_Human3.76899287
8STAT1_20625510_ChIP-Seq_HELA_Human3.38258234
9EGR1_19374776_ChIP-ChIP_THP-1_Human3.17315802
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.84805643
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.82506369
12* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.79468934
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.74056198
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.63632352
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.48602125
16ZNF274_21170338_ChIP-Seq_K562_Hela2.46671946
17BP1_19119308_ChIP-ChIP_Hs578T_Human2.38993350
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.31624674
19RUNX_20019798_ChIP-Seq_JUKART_Human2.30497562
20IRF8_21731497_ChIP-ChIP_J774_Mouse2.17780430
21IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.16444947
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.00062953
23GATA1_22025678_ChIP-Seq_K562_Human1.99930747
24* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.99884334
25MYC_19030024_ChIP-ChIP_MESCs_Mouse1.91824104
26BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.88600482
27MYC_19079543_ChIP-ChIP_MESCs_Mouse1.88472965
28MYC_18358816_ChIP-ChIP_MESCs_Mouse1.85509039
29MYC_22102868_ChIP-Seq_BL_Human1.81659500
30VDR_21846776_ChIP-Seq_THP-1_Human1.81478162
31ER_23166858_ChIP-Seq_MCF-7_Human1.79749923
32* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.79569074
33MYB_21317192_ChIP-Seq_ERMYB_Mouse1.76608454
34EST1_17652178_ChIP-ChIP_JURKAT_Human1.76197985
35NELFA_20434984_ChIP-Seq_ESCs_Mouse1.74880793
36KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.70985130
37AR_21909140_ChIP-Seq_LNCAP_Human1.69687404
38E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.69523051
39GABP_17652178_ChIP-ChIP_JURKAT_Human1.68589562
40NOTCH1_21737748_ChIP-Seq_TLL_Human1.67288508
41* XRN2_22483619_ChIP-Seq_HELA_Human1.66597546
42BCAT_22108803_ChIP-Seq_LS180_Human1.65235040
43TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.61820473
44CREB1_15753290_ChIP-ChIP_HEK293T_Human1.58459992
45JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.57111067
46SCL_19346495_ChIP-Seq_HPC-7_Human1.56785119
47VDR_23849224_ChIP-Seq_CD4+_Human1.56056726
48VDR_24787735_ChIP-Seq_THP-1_Human1.54513842
49MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.54011063
50ETS1_20019798_ChIP-Seq_JURKAT_Human1.52480394
51E2F1_21310950_ChIP-Seq_MCF-7_Human1.50581148
52EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.50458745
53* SPI1_23547873_ChIP-Seq_NB4_Human1.50085122
54STAT4_19710469_ChIP-ChIP_TH1__Mouse1.47965063
55MYB_26560356_Chip-Seq_TH1_Human1.46050083
56FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.44722493
57TAF15_26573619_Chip-Seq_HEK293_Human1.43129444
58MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.40140285
59RXR_22108803_ChIP-Seq_LS180_Human1.39948754
60STAT3_1855785_ChIP-Seq_MESCs_Mouse1.39285126
61BRD4_27068464_Chip-Seq_AML-cells_Mouse1.39136950
62FOXP3_21729870_ChIP-Seq_TREG_Human1.38235022
63SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.38162762
64MAF_26560356_Chip-Seq_TH1_Human1.37603819
65PCGF2_27294783_Chip-Seq_NPCs_Mouse1.36816191
66ELF1_17652178_ChIP-ChIP_JURKAT_Human1.36769215
67AR_20517297_ChIP-Seq_VCAP_Human1.36717785
68SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.36054979
69* MYB_26560356_Chip-Seq_TH2_Human1.34892763
70MYCN_18555785_ChIP-Seq_MESCs_Mouse1.34331025
71* GATA3_21878914_ChIP-Seq_MCF-7_Human1.34125212
72NANOG_18555785_ChIP-Seq_MESCs_Mouse1.33472564
73IRF8_27001747_Chip-Seq_BMDM_Mouse1.32535686
74EZH2_22144423_ChIP-Seq_EOC_Human1.31701088
75FOXA1_27270436_Chip-Seq_PROSTATE_Human1.31691408
76FOXA1_25329375_ChIP-Seq_VCAP_Human1.31691408
77CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.31508433
78* SPI1_23127762_ChIP-Seq_K562_Human1.30336871
79GATA3_26560356_Chip-Seq_TH1_Human1.29820763
80NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.29622798
81HOXB4_20404135_ChIP-ChIP_EML_Mouse1.29324039
82E2F1_18555785_ChIP-Seq_MESCs_Mouse1.28372725
83RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.28193993
84SMAD4_21741376_ChIP-Seq_EPCs_Human1.28055134
85IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.27506777
86E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.27059623
87RUNX1_22412390_ChIP-Seq_EML_Mouse1.26565081
88NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.24556667
89GABP_19822575_ChIP-Seq_HepG2_Human1.23468085
90EGR1_23403033_ChIP-Seq_LIVER_Mouse1.22461055
91CIITA_25753668_ChIP-Seq_RAJI_Human1.20266901
92IGF1R_20145208_ChIP-Seq_DFB_Human1.19866541
93STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.19771438
94MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18886837
95VDR_24763502_ChIP-Seq_THP-1_Human1.17972048
96SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.17304933
97DCP1A_22483619_ChIP-Seq_HELA_Human1.17032186
98KDM5A_27292631_Chip-Seq_BREAST_Human1.16956609
99SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.14891960
100GATA1_19941826_ChIP-Seq_K562_Human1.14563759
101GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.12320805
102TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11812556
103POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.11235680
104STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.11214090
105* UTX_26944678_Chip-Seq_JUKART_Human1.10252641
106TP53_16413492_ChIP-PET_HCT116_Human1.09376992
107ELK1_19687146_ChIP-ChIP_HELA_Human1.08903926
108NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.08691696
109FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08644115
110* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.08187102
111SRF_21415370_ChIP-Seq_HL-1_Mouse1.07983327
112SRY_22984422_ChIP-ChIP_TESTIS_Rat1.07630842
113IRF1_19129219_ChIP-ChIP_H3396_Human1.07536798
114TTF2_22483619_ChIP-Seq_HELA_Human1.07429695
115ZNF263_19887448_ChIP-Seq_K562_Human1.06793019
116ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06253396
117NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.06020150
118FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.05246818
119MAF_26560356_Chip-Seq_TH2_Human1.04673044
120GATA3_26560356_Chip-Seq_TH2_Human1.04455884
121TCF7_22412390_ChIP-Seq_EML_Mouse1.04205249
122TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04093113
123POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04093113
124PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04020712
125FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.03419346
126MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03361723
127CTCF_21964334_ChIP-Seq_BJAB-B_Human1.01549884
128* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.01358635
129CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.01178005
130FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.00806689
131IKZF1_21737484_ChIP-ChIP_HCT116_Human1.00595286
132LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.00580107
133GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99837046
134RAC3_21632823_ChIP-Seq_H3396_Human0.99790161
135GBX2_23144817_ChIP-Seq_PC3_Human0.99426090
136HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.99109100
137CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.98557387
138TFEB_21752829_ChIP-Seq_HELA_Human0.97932937
139KLF4_18555785_ChIP-Seq_MESCs_Mouse0.96936905
140TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.95639511
141GATA1_22383799_ChIP-Seq_G1ME_Mouse0.94175167
142GATA2_22383799_ChIP-Seq_G1ME_Mouse0.94069952
143E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93505098
144* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.93261314
145YY1_21170310_ChIP-Seq_MESCs_Mouse0.92237563
146PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.91822891
147REST_21632747_ChIP-Seq_MESCs_Mouse0.91795931
148RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.91456117
149HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.90452440
150ERG_20517297_ChIP-Seq_VCAP_Human0.90443955
151FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.89454143
152CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88103056
153P300_19829295_ChIP-Seq_ESCs_Human0.87722104
154CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.86655848
155GATA3_21867929_ChIP-Seq_TH1_Mouse0.86046344
156BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.85624676
157TP53_22573176_ChIP-Seq_HFKS_Human0.85432458
158AR_25329375_ChIP-Seq_VCAP_Human0.85002232
159ZFP57_27257070_Chip-Seq_ESCs_Mouse0.84460260
160PRDM14_20953172_ChIP-Seq_ESCs_Human0.84063325
161GATA3_27048872_Chip-Seq_THYMUS_Human0.83874698
162E2F1_18555785_Chip-Seq_ESCs_Mouse0.81776010
163KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.80877045
164KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.80877045
165KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.80877045
166* ERA_21632823_ChIP-Seq_H3396_Human0.80518190
167EZH2_27294783_Chip-Seq_ESCs_Mouse0.80009948
168FOXH1_21741376_ChIP-Seq_EPCs_Human0.79511235

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001348_abnormal_lacrimal_gland3.82819528
2MP0002139_abnormal_hepatobiliary_system3.03634527
3MP0003693_abnormal_embryo_hatching2.80826449
4MP0010094_abnormal_chromosome_stability2.67573571
5MP0003111_abnormal_nucleus_morphology2.59764971
6MP0003077_abnormal_cell_cycle2.40441270
7MP0001835_abnormal_antigen_presentation2.39824674
8MP0003195_calcinosis2.34560531
9MP0008057_abnormal_DNA_replication2.32958022
10MP0000678_abnormal_parathyroid_gland2.31736373
11MP0008007_abnormal_cellular_replicative2.29653775
12MP0002877_abnormal_melanocyte_morpholog2.12261114
13MP0005410_abnormal_fertilization2.07185858
14MP0000685_abnormal_immune_system2.01158163
15MP0005397_hematopoietic_system_phenotyp1.94428397
16MP0001545_abnormal_hematopoietic_system1.94428397
17MP0004957_abnormal_blastocyst_morpholog1.94351835
18MP0003436_decreased_susceptibility_to1.86191053
19MP0003186_abnormal_redox_activity1.85244258
20MP0004808_abnormal_hematopoietic_stem1.81204569
21MP0001800_abnormal_humoral_immune1.77513945
22MP0002396_abnormal_hematopoietic_system1.75978324
23MP0009278_abnormal_bone_marrow1.72411689
24MP0002398_abnormal_bone_marrow1.71237719
25MP0000767_abnormal_smooth_muscle1.71144452
26MP0008058_abnormal_DNA_repair1.70187224
27MP0002452_abnormal_antigen_presenting1.66731813
28MP0004130_abnormal_muscle_cell1.66268719
29MP0003763_abnormal_thymus_physiology1.65405121
30MP0008875_abnormal_xenobiotic_pharmacok1.63462901
31MP0010307_abnormal_tumor_latency1.63138244
32MP0001853_heart_inflammation1.61761118
33MP0009785_altered_susceptibility_to1.58389774
34MP0002723_abnormal_immune_serum1.55461989
35MP0002405_respiratory_system_inflammati1.52952048
36MP0002420_abnormal_adaptive_immunity1.51912543
37MP0000689_abnormal_spleen_morphology1.51212604
38MP0005000_abnormal_immune_tolerance1.50931391
39MP0010352_gastrointestinal_tract_polyps1.50787763
40MP0001819_abnormal_immune_cell1.50507754
41MP0005387_immune_system_phenotype1.49675571
42MP0001790_abnormal_immune_system1.49675571
43MP0002419_abnormal_innate_immunity1.49231507
44MP0005025_abnormal_response_to1.48007575
45MP0000569_abnormal_digit_pigmentation1.46816340
46MP0002148_abnormal_hypersensitivity_rea1.46791315
47MP0009333_abnormal_splenocyte_physiolog1.45872746
48MP0005174_abnormal_tail_pigmentation1.45814847
49MP0008961_abnormal_basal_metabolism1.45457866
50MP0002722_abnormal_immune_system1.45420119
51MP0005464_abnormal_platelet_physiology1.42656899
52MP0004782_abnormal_surfactant_physiolog1.42120329
53MP0000716_abnormal_immune_system1.41999808
54MP0000350_abnormal_cell_proliferation1.40434753
55MP0004947_skin_inflammation1.40362342
56MP0005671_abnormal_response_to1.40128386
57MP0000490_abnormal_crypts_of1.40103768
58MP0002138_abnormal_hepatobiliary_system1.39569921
59MP0002638_abnormal_pupillary_reflex1.39509392
60MP0005451_abnormal_body_composition1.37227843
61MP0009840_abnormal_foam_cell1.37060328
62MP0005076_abnormal_cell_differentiation1.35692678
63MP0001663_abnormal_digestive_system1.34030073
64MP0004381_abnormal_hair_follicle1.31627120
65MP0002429_abnormal_blood_cell1.31398569
66MP0000858_altered_metastatic_potential1.29894776
67MP0003786_premature_aging1.28907063
68MP0003183_abnormal_peptide_metabolism1.28016744
69MP0003806_abnormal_nucleotide_metabolis1.27002576
70MP0000313_abnormal_cell_death1.24606504
71MP0002928_abnormal_bile_duct1.24534991
72MP0004145_abnormal_muscle_electrophysio1.23052935
73MP0000703_abnormal_thymus_morphology1.21817349
74MP0005423_abnormal_somatic_nervous1.20065805
75MP0003566_abnormal_cell_adhesion1.19479050
76MP0004147_increased_porphyrin_level1.18991442
77MP0008872_abnormal_physiological_respon1.18394940
78MP0010155_abnormal_intestine_physiology1.17911358
79MP0003646_muscle_fatigue1.17001613
80MP0000343_altered_response_to1.16669382
81MP0003011_delayed_dark_adaptation1.16473312
82MP0003724_increased_susceptibility_to1.15946061
83MP0003448_altered_tumor_morphology1.15316387
84MP0001730_embryonic_growth_arrest1.14811676
85MP0001919_abnormal_reproductive_system1.14725749
86MP0006292_abnormal_olfactory_placode1.12761729
87MP0006082_CNS_inflammation1.12366589
88MP0002019_abnormal_tumor_incidence1.11340675
89MP0005670_abnormal_white_adipose1.09893076
90MP0005023_abnormal_wound_healing1.09473022
91MP0005075_abnormal_melanosome_morpholog1.08129596
92MP0001845_abnormal_inflammatory_respons1.05951117
93MP0003191_abnormal_cellular_cholesterol1.05208545
94MP0001929_abnormal_gametogenesis1.03994347
95MP0001672_abnormal_embryogenesis/_devel1.01971882
96MP0005380_embryogenesis_phenotype1.01971882
97MP0001666_abnormal_nutrient_absorption1.01930888
98MP0003984_embryonic_growth_retardation1.00097489
99MP0005408_hypopigmentation0.99773208
100MP0009764_decreased_sensitivity_to0.99757577
101MP0005389_reproductive_system_phenotype0.99564344
102MP0000467_abnormal_esophagus_morphology0.99353548
103MP0002277_abnormal_respiratory_mucosa0.98732446
104MP0003115_abnormal_respiratory_system0.98649145
105MP0002088_abnormal_embryonic_growth/wei0.96988312
106MP0001849_ear_inflammation0.96475226
107MP0000015_abnormal_ear_pigmentation0.96255184
108MP0003172_abnormal_lysosome_physiology0.94672710
109MP0004510_myositis0.94062051
110MP0002166_altered_tumor_susceptibility0.93602079
111MP0001664_abnormal_digestion0.93598008
112MP0000427_abnormal_hair_cycle0.92964784
113MP0000465_gastrointestinal_hemorrhage0.90440636
114MP0008877_abnormal_DNA_methylation0.90134368
115MP0000049_abnormal_middle_ear0.89227829
116MP0008469_abnormal_protein_level0.88631244
117MP0003303_peritoneal_inflammation0.88289149
118MP0001915_intracranial_hemorrhage0.88287887
119MP0003300_gastrointestinal_ulcer0.85877645
120MP0006054_spinal_hemorrhage0.85833881
121MP0008932_abnormal_embryonic_tissue0.85185799
122MP0001533_abnormal_skeleton_physiology0.84917509
123MP0002933_joint_inflammation0.84658289
124MP0000470_abnormal_stomach_morphology0.83321919
125MP0002210_abnormal_sex_determination0.83120406
126MP0001697_abnormal_embryo_size0.83105836
127MP0003828_pulmonary_edema0.82174015
128MP0005381_digestive/alimentary_phenotyp0.80607678
129MP0002127_abnormal_cardiovascular_syste0.78636282
130MP0000383_abnormal_hair_follicle0.78572110
131MP0003950_abnormal_plasma_membrane0.78358790
132MP0000566_synostosis0.77551152
133MP0002163_abnormal_gland_morphology0.76825437
134MP0002086_abnormal_extraembryonic_tissu0.76243467
135MP0000428_abnormal_craniofacial_morphol0.76044475
136MP0000371_diluted_coat_color0.75315341
137MP0002080_prenatal_lethality0.73765760
138MP0002006_tumorigenesis0.73509299
139MP0004043_abnormal_pH_regulation0.73232476
140MP0010678_abnormal_skin_adnexa0.72426726
141MP0003941_abnormal_skin_development0.72426316
142MP0003567_abnormal_fetal_cardiomyocyte0.71913953
143MP0004197_abnormal_fetal_growth/weight/0.71663160
144MP0005083_abnormal_biliary_tract0.70683823
145MP0003453_abnormal_keratinocyte_physiol0.69205156
146MP0003959_abnormal_lean_body0.69174841
147MP0001765_abnormal_ion_homeostasis0.69105844
148MP0005085_abnormal_gallbladder_physiolo0.67655146
149MP0003045_fibrosis0.67647015
150MP0001529_abnormal_vocalization0.65888203
151MP0009115_abnormal_fat_cell0.65483930
152MP0002735_abnormal_chemical_nociception0.64099628
153MP0004142_abnormal_muscle_tone0.63452740
154MP0004883_abnormal_blood_vessel0.63209739
155MP0002249_abnormal_larynx_morphology0.62540404
156MP0003943_abnormal_hepatobiliary_system0.62110485
157MP0005595_abnormal_vascular_smooth0.61065189
158MP0001986_abnormal_taste_sensitivity0.59648955
159MP0003283_abnormal_digestive_organ0.59559688
160MP0002909_abnormal_adrenal_gland0.58223233
161MP0005310_abnormal_salivary_gland0.57509100
162MP0008995_early_reproductive_senescence0.56512899
163MP0000750_abnormal_muscle_regeneration0.55991072

Predicted human phenotypes

RankGene SetZ-score
1Severe short stature (HP:0003510)7.47426594
2Growth hormone deficiency (HP:0000824)6.89893415
3Stomatitis (HP:0010280)4.97907591
4Large for gestational age (HP:0001520)4.36805386
5Deep palmar crease (HP:0006191)4.01514718
6Abnormality of the anterior horn cell (HP:0006802)3.93151493
7Degeneration of anterior horn cells (HP:0002398)3.93151493
8Duplicated collecting system (HP:0000081)3.80343113
9Eczematoid dermatitis (HP:0000976)3.63426319
10Nasal polyposis (HP:0100582)3.57429727
11Abnormality of the renal collecting system (HP:0004742)3.56882808
12Chronic otitis media (HP:0000389)3.55655698
13Constricted visual fields (HP:0001133)3.53674738
14Recurrent abscess formation (HP:0002722)3.41478509
15Hypobetalipoproteinemia (HP:0003563)3.18491804
16Abnormality of the nasal mucosa (HP:0000433)3.10873001
17Recurrent bacterial skin infections (HP:0005406)3.09736381
18Gastrointestinal stroma tumor (HP:0100723)3.06137966
19Birth length less than 3rd percentile (HP:0003561)2.95841991
20Adactyly (HP:0009776)2.94254892
21Elevated erythrocyte sedimentation rate (HP:0003565)2.92916911
22Palpebral edema (HP:0100540)2.85167498
23Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.85143346
24Oligodontia (HP:0000677)2.82019559
25Absent rod-and cone-mediated responses on ERG (HP:0007688)2.76975109
26Abnormal delayed hypersensitivity skin test (HP:0002963)2.76189571
27Congenital stationary night blindness (HP:0007642)2.74467610
28Petechiae (HP:0000967)2.72309628
29Menstrual irregularities (HP:0000858)2.71693439
30Autoimmune thrombocytopenia (HP:0001973)2.69566445
31Recurrent bronchitis (HP:0002837)2.62532627
32Recurrent viral infections (HP:0004429)2.61952330
33Mediastinal lymphadenopathy (HP:0100721)2.60924626
34Aplasia/Hypoplasia of the uvula (HP:0010293)2.56928648
35Meckel diverticulum (HP:0002245)2.53700952
36Recurrent fungal infections (HP:0002841)2.52530991
37Premature skin wrinkling (HP:0100678)2.52321031
38Conjunctival hamartoma (HP:0100780)2.51804183
39Hyperventilation (HP:0002883)2.45497364
40Recurrent gram-negative bacterial infections (HP:0005420)2.42482117
41Myositis (HP:0100614)2.41978622
42Abnormality of the heme biosynthetic pathway (HP:0010472)2.41395460
43Abnormal number of erythroid precursors (HP:0012131)2.41314070
44Abnormality of the ileum (HP:0001549)2.40136042
45Myelodysplasia (HP:0002863)2.40101454
46Agnosia (HP:0010524)2.39748702
47Abnormal rod and cone electroretinograms (HP:0008323)2.37454256
48Aplasia/Hypoplasia involving the musculature (HP:0001460)2.37181448
49Verrucae (HP:0200043)2.37142524
50Papilloma (HP:0012740)2.37142524
51Lymphopenia (HP:0001888)2.36179851
52Lip pit (HP:0100267)2.35959739
53Agitation (HP:0000713)2.34288010
54Thrombocytosis (HP:0001894)2.33122379
55Abnormality of the preputium (HP:0100587)2.32551658
56Abnormality of cells of the erythroid lineage (HP:0012130)2.32414141
57Short nail (HP:0001799)2.31720434
58Recurrent pneumonia (HP:0006532)2.29859923
59Hypoplasia of the capital femoral epiphysis (HP:0003090)2.28690624
60Reduced antithrombin III activity (HP:0001976)2.28024121
61Acute myeloid leukemia (HP:0004808)2.27318667
62Abnormality of T cell physiology (HP:0011840)2.26687059
63Bronchitis (HP:0012387)2.26155902
64Abnormal platelet function (HP:0011869)2.25010393
65Impaired platelet aggregation (HP:0003540)2.25010393
66Pustule (HP:0200039)2.24939260
67Abnormality of chromosome stability (HP:0003220)2.23828449
68B lymphocytopenia (HP:0010976)2.22966163
69Hypoplastic pelvis (HP:0008839)2.20579161
70Bone marrow hypocellularity (HP:0005528)2.20464540
71Cellulitis (HP:0100658)2.19689033
72Abnormal respiratory motile cilium morphology (HP:0005938)2.19559775
73Abnormal respiratory epithelium morphology (HP:0012253)2.19559775
74Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.18318056
75Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.17273003
7611 pairs of ribs (HP:0000878)2.17172940
77Obstructive sleep apnea (HP:0002870)2.16154828
78Chromosomal breakage induced by crosslinking agents (HP:0003221)2.15774582
79Impulsivity (HP:0100710)2.12723811
80Mitral stenosis (HP:0001718)2.10427353
81Breast hypoplasia (HP:0003187)2.10203769
82Polymicrogyria (HP:0002126)2.09762021
83Hematochezia (HP:0002573)2.09310758
84Granulocytopenia (HP:0001913)2.09250692
85Clubbing of toes (HP:0100760)2.08104770
86Fibular aplasia (HP:0002990)2.06770685
87IgM deficiency (HP:0002850)2.06393701
88Abnormality of macrophages (HP:0004311)2.06289988
89Abnormality of B cell number (HP:0010975)2.05201927
90Reticulocytopenia (HP:0001896)2.05152309
91Acute lymphatic leukemia (HP:0006721)2.05010667
92Decreased circulating renin level (HP:0003351)2.04840858
93Long foot (HP:0001833)2.04233355
94Type I diabetes mellitus (HP:0100651)2.04127193
95Absent thumb (HP:0009777)2.03456049
96Colitis (HP:0002583)2.01958075
97Keratoconjunctivitis (HP:0001096)2.01732196
98Recurrent skin infections (HP:0001581)1.97936644
99T lymphocytopenia (HP:0005403)1.97770744
100Arterial thrombosis (HP:0004420)1.97665953
101Keratoconjunctivitis sicca (HP:0001097)1.97507914
102Widely spaced teeth (HP:0000687)1.97465524
103Mesomelia (HP:0003027)1.97327807
104Abnormality of the pons (HP:0007361)1.95920265
105Breast aplasia (HP:0100783)1.95742456
106Hyperkalemia (HP:0002153)1.95636670
107Pancreatic fibrosis (HP:0100732)1.95036640
108Chromsome breakage (HP:0040012)1.94935584
109Recurrent sinusitis (HP:0011108)1.94235013
110Ureteral duplication (HP:0000073)1.94195357
111Hypoplasia of the uterus (HP:0000013)1.94012961
112Aplastic anemia (HP:0001915)1.93543907
113Leukopenia (HP:0001882)1.92818339
114Ectopic kidney (HP:0000086)1.92729601
115Hemiplegia (HP:0002301)1.92593770
116Rough bone trabeculation (HP:0100670)1.90830111
117Chronic obstructive pulmonary disease (HP:0006510)1.90699321
118Obstructive lung disease (HP:0006536)1.90699321
119Hypochromic microcytic anemia (HP:0004840)1.89897337
120Selective tooth agenesis (HP:0001592)1.89875039
121Microcytic anemia (HP:0001935)1.89549484
122Gastrointestinal infarctions (HP:0005244)1.89264510
123Chronic sinusitis (HP:0011109)1.88729527
124Orchitis (HP:0100796)1.88506318
125Abnormality of cells of the lymphoid lineage (HP:0012140)1.87733095
126Brushfield spots (HP:0001088)1.87621671
127Carpal bone hypoplasia (HP:0001498)1.86561459
128Gastrointestinal inflammation (HP:0004386)1.86098843
129Eosinophilia (HP:0001880)1.86063493
130Abnormality of T cells (HP:0002843)1.85751545
131Small intestinal stenosis (HP:0012848)1.84155306
132Duodenal stenosis (HP:0100867)1.84155306
133Poikiloderma (HP:0001029)1.83982179
134Meningitis (HP:0001287)1.83390790
135Aplasia/Hypoplasia of the fovea (HP:0008060)1.82831298
136Hypoplasia of the fovea (HP:0007750)1.82831298
137Prolonged bleeding time (HP:0003010)1.82792093
138Inflammation of the large intestine (HP:0002037)1.82525875
139Leukocytosis (HP:0001974)1.81775290
140Abnormality of eosinophils (HP:0001879)1.80040736
141Decreased electroretinogram (ERG) amplitude (HP:0000654)1.79906714
142Fatigue (HP:0012378)1.79046930
143Lymphoma (HP:0002665)1.78530159
144Abnormality of the columella (HP:0009929)1.78417564
145Dynein arm defect of respiratory motile cilia (HP:0012255)1.78219477
146Absent/shortened dynein arms (HP:0200106)1.78219477
147Muscle fiber atrophy (HP:0100295)1.78073311
148High pitched voice (HP:0001620)1.76200068
149Wide intermamillary distance (HP:0006610)1.76171374
150Cleft eyelid (HP:0000625)1.75813333
151Aplasia/Hypoplasia of the patella (HP:0006498)1.75586675
152Abnormal protein glycosylation (HP:0012346)1.74716488
153Abnormal glycosylation (HP:0012345)1.74716488
154Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.74716488
155Abnormal protein N-linked glycosylation (HP:0012347)1.74716488
156Retrobulbar optic neuritis (HP:0100654)1.73621246
157Optic neuritis (HP:0100653)1.73621246
158Muscle fibrillation (HP:0010546)1.73477302
159Abnormal platelet volume (HP:0011876)1.73039367
160Vasculitis (HP:0002633)1.72971826
161Gingival bleeding (HP:0000225)1.72601963
162Personality changes (HP:0000751)1.72274623
163Pulmonary artery stenosis (HP:0004415)1.72022361
164Chronic bronchitis (HP:0004469)1.71590815
165Patellar aplasia (HP:0006443)1.71375052
166Pseudobulbar signs (HP:0002200)1.71355898
167Basal ganglia calcification (HP:0002135)1.70994085
168Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.70965265
169Bony spicule pigmentary retinopathy (HP:0007737)1.70521568
170Periodontitis (HP:0000704)1.70502884
171Aplasia/hypoplasia of the uterus (HP:0008684)1.69996954
172Recurrent cutaneous fungal infections (HP:0011370)1.69743222
173Chronic mucocutaneous candidiasis (HP:0002728)1.69743222
174Recurrent lower respiratory tract infections (HP:0002783)1.69567237
175Increased IgE level (HP:0003212)1.68347937

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK13.42947940
2MAP3K13.21895595
3BUB12.94134276
4CDC72.72994615
5NEK22.47799226
6STK102.46725159
7CDK192.40720949
8WEE12.20621920
9MKNK22.12026912
10MAP3K142.04097526
11TESK12.01402891
12RPS6KA41.96861760
13MAP4K11.96778712
14NME21.95886503
15MKNK11.95407646
16GRK61.93712079
17KSR21.78193173
18STK41.74994783
19TYK21.73162056
20MAP3K21.69900271
21MAP3K101.69012755
22FRK1.68858963
23IKBKB1.67383987
24SRPK11.67064252
25MAP3K121.63237878
26BRSK21.61954686
27TBK11.59323326
28STK31.58631930
29ZAK1.57561626
30BRSK11.46520253
31PIM21.46324166
32JAK31.44553009
33MAP2K41.43121489
34OXSR11.41126583
35CAMK1D1.40913774
36IRAK11.40876602
37PIM11.40292143
38KIT1.39730796
39TAOK21.39342329
40VRK11.38775623
41PDK31.38740498
42PDK41.38740498
43IKBKE1.36905818
44TESK21.32194322
45CDK121.27643863
46MAP2K31.26381892
47DYRK31.26339864
48CSF1R1.26102701
49STK38L1.24902946
50MARK31.24636499
51PBK1.24568679
52ZAP701.24070830
53PRKD21.20716412
54FLT31.19453966
55PIK3CG1.18898011
56MAP3K31.18642881
57PLK11.18452382
58HIPK21.16655914
59EIF2AK11.12886421
60TTK1.12625517
61IRAK41.11535972
62STK241.10812320
63ADRBK21.09227944
64PAK31.08833990
65CSK1.05344944
66FGFR41.04813080
67STK161.04052077
68EIF2AK31.03818008
69CHUK1.03367784
70AURKA1.03040333
71RPS6KB21.02979974
72RAF10.99754110
73CLK10.99655603
74PLK40.99558260
75TSSK60.97920161
76BRAF0.96567765
77FES0.94432515
78AURKB0.94224299
79MAP3K130.92798628
80CDK40.92790556
81LRRK20.92331591
82CHEK20.92130911
83CAMK1G0.91800579
84ATR0.91483882
85IRAK30.88547450
86RIPK40.88434465
87MAP3K80.86352849
88CDK70.85186963
89JAK20.84902398
90PDK20.84655092
91STK110.83377457
92YES10.82095579
93ERN10.81939804
94TXK0.81906395
95PLK30.81419899
96CDK60.80795667
97SIK30.80603628
98PTK2B0.78370590
99ARAF0.77620095
100CAMKK10.76373826
101BLK0.76320073
102MAP4K20.75997915
103EIF2AK20.75593565
104KSR10.75564584
105CAMKK20.75425549
106BTK0.74905820
107ACVR1B0.74777812
108TAOK30.72127491
109MAPKAPK30.71370222
110MAPKAPK20.67884728
111CHEK10.67880523
112PAK40.67426966
113TLK10.65412034
114KDR0.64528549
115TEC0.61121319
116NUAK10.61037093
117CASK0.60842874
118FGFR30.58877842
119LCK0.58059100
120PRKCQ0.57320873
121ABL20.56547958
122MELK0.55968398
123EPHB20.55894011
124BMPR20.55806510
125SYK0.55177569
126MATK0.55039052
127TGFBR20.54308507
128MAP3K50.53191868
129DAPK20.52960997
130RIPK10.52333972
131TRPM70.52010609
132EPHA20.51489185
133TGFBR10.51419487
134MAP3K90.50445338
135PRKAA20.49552649
136IRAK20.49183459
137EEF2K0.48234449
138NEK90.45867012
139MAPK110.45863031
140HCK0.45736667
141LYN0.45560998
142SGK20.44771340
143ITK0.43429053
144MAP3K110.43213256
145AKT30.41247876
146PDK10.41217246
147TRIB30.40949659
148ATM0.40933251
149PINK10.40814390
150MARK20.38809207
151BMPR1B0.38750992
152MAP3K70.36275268
153CAMK40.36123801
154DYRK1A0.34513985
155WNK40.34055856
156PLK20.33405449
157ERBB20.32752149
158TIE10.32085677
159BCKDK0.32025671
160PDPK10.31843201
161MAPK70.26635122
162SIK20.26491901
163EPHA30.24792242
164FGR0.24037352

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.68431873
2Mismatch repair_Homo sapiens_hsa034302.81921451
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.44915066
4Fanconi anemia pathway_Homo sapiens_hsa034602.24995676
5Dorso-ventral axis formation_Homo sapiens_hsa043202.21345705
6Base excision repair_Homo sapiens_hsa034102.20220697
7RNA polymerase_Homo sapiens_hsa030202.16746374
8Proteasome_Homo sapiens_hsa030502.16720630
9Homologous recombination_Homo sapiens_hsa034402.16073652
10Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.15312065
11RNA transport_Homo sapiens_hsa030132.09358265
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.08561182
13One carbon pool by folate_Homo sapiens_hsa006702.07497636
14Spliceosome_Homo sapiens_hsa030402.06613124
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.04652735
16Pyrimidine metabolism_Homo sapiens_hsa002401.99098992
17Cell cycle_Homo sapiens_hsa041101.90848175
18p53 signaling pathway_Homo sapiens_hsa041151.85894087
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.82228384
20Ribosome_Homo sapiens_hsa030101.75592604
21Non-small cell lung cancer_Homo sapiens_hsa052231.67824709
22Herpes simplex infection_Homo sapiens_hsa051681.67171433
23Antigen processing and presentation_Homo sapiens_hsa046121.66995361
24Platelet activation_Homo sapiens_hsa046111.65236431
25Nucleotide excision repair_Homo sapiens_hsa034201.62928804
26Selenocompound metabolism_Homo sapiens_hsa004501.53576042
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.49433755
28Leishmaniasis_Homo sapiens_hsa051401.47653886
29ABC transporters_Homo sapiens_hsa020101.46453832
30Measles_Homo sapiens_hsa051621.42433544
31Melanoma_Homo sapiens_hsa052181.40160032
32Epstein-Barr virus infection_Homo sapiens_hsa051691.39404977
33Legionellosis_Homo sapiens_hsa051341.37722556
34Primary immunodeficiency_Homo sapiens_hsa053401.33395707
35MAPK signaling pathway_Homo sapiens_hsa040101.30343650
36B cell receptor signaling pathway_Homo sapiens_hsa046621.28643240
37GnRH signaling pathway_Homo sapiens_hsa049121.25895233
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.25796757
39Pentose phosphate pathway_Homo sapiens_hsa000301.24893781
40Apoptosis_Homo sapiens_hsa042101.24667447
41Chemokine signaling pathway_Homo sapiens_hsa040621.24305072
42Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.22316400
43Basal transcription factors_Homo sapiens_hsa030221.22276612
44RNA degradation_Homo sapiens_hsa030181.22166205
45Oxytocin signaling pathway_Homo sapiens_hsa049211.19474942
46Morphine addiction_Homo sapiens_hsa050321.18381342
47Influenza A_Homo sapiens_hsa051641.17878849
48Non-homologous end-joining_Homo sapiens_hsa034501.17810969
49Intestinal immune network for IgA production_Homo sapiens_hsa046721.13952902
50SNARE interactions in vesicular transport_Homo sapiens_hsa041301.12769265
51Osteoclast differentiation_Homo sapiens_hsa043801.11606570
52Regulation of autophagy_Homo sapiens_hsa041401.11328177
53Glycosaminoglycan degradation_Homo sapiens_hsa005311.09491982
54NOD-like receptor signaling pathway_Homo sapiens_hsa046211.04382477
55Purine metabolism_Homo sapiens_hsa002301.03909765
56Nitrogen metabolism_Homo sapiens_hsa009101.02551799
57mRNA surveillance pathway_Homo sapiens_hsa030151.01838193
58Fatty acid biosynthesis_Homo sapiens_hsa000611.01820130
59Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.00598532
60Phagosome_Homo sapiens_hsa041451.00371939
61Linoleic acid metabolism_Homo sapiens_hsa005911.00301107
62Shigellosis_Homo sapiens_hsa051311.00177604
63Viral carcinogenesis_Homo sapiens_hsa052030.99107642
64Renal cell carcinoma_Homo sapiens_hsa052110.98069857
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.95817940
66Maturity onset diabetes of the young_Homo sapiens_hsa049500.95552817
67TNF signaling pathway_Homo sapiens_hsa046680.95407254
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.94282436
69Toll-like receptor signaling pathway_Homo sapiens_hsa046200.93295206
70Folate biosynthesis_Homo sapiens_hsa007900.90354183
71Cholinergic synapse_Homo sapiens_hsa047250.90119043
72ErbB signaling pathway_Homo sapiens_hsa040120.90002602
73Viral myocarditis_Homo sapiens_hsa054160.89902701
74Drug metabolism - other enzymes_Homo sapiens_hsa009830.89535547
75Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.88470956
76Glutathione metabolism_Homo sapiens_hsa004800.87221443
77Toxoplasmosis_Homo sapiens_hsa051450.87046233
78Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.85996228
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.85219031
80Sulfur relay system_Homo sapiens_hsa041220.83931645
81Hematopoietic cell lineage_Homo sapiens_hsa046400.83480593
82HTLV-I infection_Homo sapiens_hsa051660.82930788
83Acute myeloid leukemia_Homo sapiens_hsa052210.82498080
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.81795349
85Hepatitis B_Homo sapiens_hsa051610.80934279
86Small cell lung cancer_Homo sapiens_hsa052220.80098466
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.77926135
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.77046719
89Jak-STAT signaling pathway_Homo sapiens_hsa046300.76248817
90Olfactory transduction_Homo sapiens_hsa047400.75829446
91Staphylococcus aureus infection_Homo sapiens_hsa051500.72908319
92Glioma_Homo sapiens_hsa052140.72733824
93Ovarian steroidogenesis_Homo sapiens_hsa049130.72635387
94Other glycan degradation_Homo sapiens_hsa005110.71883783
95Estrogen signaling pathway_Homo sapiens_hsa049150.69611079
96Ras signaling pathway_Homo sapiens_hsa040140.69209396
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.68091591
98Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.66552444
99Systemic lupus erythematosus_Homo sapiens_hsa053220.66266223
100FoxO signaling pathway_Homo sapiens_hsa040680.65704063
101Malaria_Homo sapiens_hsa051440.65177631
102MicroRNAs in cancer_Homo sapiens_hsa052060.65144427
103Prolactin signaling pathway_Homo sapiens_hsa049170.64979333
104cAMP signaling pathway_Homo sapiens_hsa040240.64908612
105Allograft rejection_Homo sapiens_hsa053300.64603782
106Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.63933077
107PI3K-Akt signaling pathway_Homo sapiens_hsa041510.62906076
108Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.61319569
109Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.60691869
110Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.60535785
111Galactose metabolism_Homo sapiens_hsa000520.60455343
112Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59921944
113Notch signaling pathway_Homo sapiens_hsa043300.59910516
114T cell receptor signaling pathway_Homo sapiens_hsa046600.57161061
115Chronic myeloid leukemia_Homo sapiens_hsa052200.56997613
116Tuberculosis_Homo sapiens_hsa051520.56940379
117Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56274235
118Tryptophan metabolism_Homo sapiens_hsa003800.55858356
119Rap1 signaling pathway_Homo sapiens_hsa040150.55800846
120Thyroid cancer_Homo sapiens_hsa052160.54999526
121Glutamatergic synapse_Homo sapiens_hsa047240.54569589
122Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53564936
123Sphingolipid signaling pathway_Homo sapiens_hsa040710.53231737
124Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51454867
125GABAergic synapse_Homo sapiens_hsa047270.50897071
126Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50546022
127Leukocyte transendothelial migration_Homo sapiens_hsa046700.50361894
128Autoimmune thyroid disease_Homo sapiens_hsa053200.49491963
129Bile secretion_Homo sapiens_hsa049760.48462520
130Collecting duct acid secretion_Homo sapiens_hsa049660.48188692
131Neurotrophin signaling pathway_Homo sapiens_hsa047220.47180611
132Gastric acid secretion_Homo sapiens_hsa049710.45927313
133Pertussis_Homo sapiens_hsa051330.45659425
134Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45431333
135Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45262693
136Hepatitis C_Homo sapiens_hsa051600.45209003
137Biosynthesis of amino acids_Homo sapiens_hsa012300.45100489
138Prostate cancer_Homo sapiens_hsa052150.44426460
139Steroid hormone biosynthesis_Homo sapiens_hsa001400.43914864
140Circadian entrainment_Homo sapiens_hsa047130.43859134
141Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43720929
142HIF-1 signaling pathway_Homo sapiens_hsa040660.43215541
143Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43108243
144Phototransduction_Homo sapiens_hsa047440.43048876
145Rheumatoid arthritis_Homo sapiens_hsa053230.43026075
146Asthma_Homo sapiens_hsa053100.42479540
147Taste transduction_Homo sapiens_hsa047420.40683344
148Vitamin B6 metabolism_Homo sapiens_hsa007500.39646707
149Salmonella infection_Homo sapiens_hsa051320.37701434
150Adipocytokine signaling pathway_Homo sapiens_hsa049200.37631607
151Pancreatic cancer_Homo sapiens_hsa052120.35672137
152Aldosterone synthesis and secretion_Homo sapiens_hsa049250.35669099
153Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35576491
154Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.34332575
155Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33968077
156Bladder cancer_Homo sapiens_hsa052190.33958784
157AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.31670897
158Graft-versus-host disease_Homo sapiens_hsa053320.31014581
159Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.30215683
160Caffeine metabolism_Homo sapiens_hsa002320.30064069

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