NAMPT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. The protein belongs to the nicotinic acid phosphoribosyltransferase (NAPRTase) family and is thought to be involved in many important biological processes, including metabolism, stress response and aging. This gene has a pseudogene on chromosome 10. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of molecule of bacterial origin (GO:0032490)6.26038859
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.79243572
3positive regulation of interferon-alpha production (GO:0032727)5.46590612
4neutrophil activation involved in immune response (GO:0002283)5.29870682
5positive regulation of gamma-delta T cell activation (GO:0046645)5.26357523
6negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.21597480
7negative regulation of cell killing (GO:0031342)5.21597480
8regulation of interferon-alpha production (GO:0032647)5.15621876
9negative regulation of interleukin-12 production (GO:0032695)4.88547593
10detection of external biotic stimulus (GO:0098581)4.80753091
11cellular extravasation (GO:0045123)4.74343946
12detection of other organism (GO:0098543)4.67593055
13* positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.66236270
14positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)4.59164778
15microglial cell activation (GO:0001774)4.57705713
16hydrogen peroxide biosynthetic process (GO:0050665)4.54066873
17response to peptidoglycan (GO:0032494)4.53042290
18positive regulation of chemokine biosynthetic process (GO:0045080)4.52972908
19positive regulation of heat generation (GO:0031652)4.40622794
20lipopolysaccharide-mediated signaling pathway (GO:0031663)4.40165850
21macrophage activation (GO:0042116)4.39458102
22neutrophil mediated immunity (GO:0002446)4.31277761
23detection of biotic stimulus (GO:0009595)4.29062343
24natural killer cell mediated immunity (GO:0002228)4.27823808
25natural killer cell mediated cytotoxicity (GO:0042267)4.27823808
26regulation of B cell receptor signaling pathway (GO:0050855)4.25442041
27regulation of fever generation (GO:0031620)4.23683715
28positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.17854662
29immunoglobulin mediated immune response (GO:0016064)4.16792742
30cellular response to type I interferon (GO:0071357)4.03168366
31type I interferon signaling pathway (GO:0060337)4.03168366
32response to type I interferon (GO:0034340)4.01588103
33regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)4.01141892
34reactive oxygen species biosynthetic process (GO:1903409)4.00829576
35positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.00630624
36positive regulation by symbiont of host defense response (GO:0052509)3.98030835
37modulation by symbiont of host defense response (GO:0052031)3.98030835
38modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.98030835
39modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.98030835
40positive regulation by organism of defense response of other organism involved in symbiotic interact3.98030835
41modulation by symbiont of host immune response (GO:0052553)3.98030835
42positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.97913223
43response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.96536082
44response to host (GO:0075136)3.96536082
45response to host defenses (GO:0052200)3.96536082
46detection of bacterium (GO:0016045)3.90820462
47granulocyte activation (GO:0036230)3.90405003
48regulation of gamma-delta T cell activation (GO:0046643)3.90071243
49respiratory burst (GO:0045730)3.89941742
50regulation of chemokine biosynthetic process (GO:0045073)3.88576457
51cellular response to zinc ion (GO:0071294)3.82852517
52negative regulation of lymphocyte mediated immunity (GO:0002707)3.75300423
53regulation of T-helper 1 cell differentiation (GO:0045625)3.69378573
54positive regulation of interferon-beta production (GO:0032728)3.67523039
55antigen processing and presentation of endogenous antigen (GO:0019883)3.65625159
56myeloid leukocyte mediated immunity (GO:0002444)3.65165147
57germinal center formation (GO:0002467)3.64452710
58myeloid dendritic cell differentiation (GO:0043011)3.62262799
59neutrophil activation (GO:0042119)3.61972338
60positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.60348578
61positive regulation of natural killer cell differentiation (GO:0032825)3.56602740
62cellular response to virus (GO:0098586)3.55150097
63response to muramyl dipeptide (GO:0032495)3.54349032
64response to interleukin-15 (GO:0070672)3.53225747
65regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.52840119
66superoxide anion generation (GO:0042554)3.51096603
67leukocyte migration involved in inflammatory response (GO:0002523)3.50769502
68T-helper 1 type immune response (GO:0042088)3.48633362
69regulation of vitamin D biosynthetic process (GO:0060556)3.47986609
70cellular response to interferon-alpha (GO:0035457)3.47497365
71regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.45987516
72B cell mediated immunity (GO:0019724)3.43766968
73positive regulation of interleukin-12 production (GO:0032735)3.41956995
74regulation of T-helper 2 cell differentiation (GO:0045628)3.40469769
75macrophage activation involved in immune response (GO:0002281)3.37765214
76response to interferon-alpha (GO:0035455)3.37452554
77low-density lipoprotein particle clearance (GO:0034383)3.36451855
78regulation of heat generation (GO:0031650)3.35012730
79production of molecular mediator involved in inflammatory response (GO:0002532)3.32606722
80cellular response to exogenous dsRNA (GO:0071360)3.32171219
81negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.32095923
82leukocyte mediated cytotoxicity (GO:0001909)3.31983078
83antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.31911121
84antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.31911121
85negative regulation of T cell mediated immunity (GO:0002710)3.30875465
86interferon-gamma-mediated signaling pathway (GO:0060333)3.29712382
87defense response to protozoan (GO:0042832)3.29306221
88negative regulation of viral genome replication (GO:0045071)3.28246524
89regulation of activation of Janus kinase activity (GO:0010533)3.27796857
90positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.27528808
91leukocyte aggregation (GO:0070486)3.27056700
92regulation of gamma-delta T cell differentiation (GO:0045586)3.26581872
93regulation of interleukin-8 biosynthetic process (GO:0045414)3.25304244
94negative regulation of leukocyte mediated immunity (GO:0002704)3.23294451
95regulation of RIG-I signaling pathway (GO:0039535)3.20162077
96negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.19873309
97negative regulation of T-helper cell differentiation (GO:0045623)3.19873309
98* regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.19317204
99regulation of cholesterol storage (GO:0010885)3.17786620
100positive regulation of toll-like receptor signaling pathway (GO:0034123)3.17473260
101negative regulation of lipid storage (GO:0010888)3.17177003
102cellular response to interferon-beta (GO:0035458)3.15436475
103monocyte chemotaxis (GO:0002548)3.14214479
104myeloid dendritic cell activation (GO:0001773)3.12243990
105positive regulation of type 2 immune response (GO:0002830)3.09037628
106cellular response to interleukin-15 (GO:0071350)3.08514105
107cytokine secretion (GO:0050663)3.08482449
108regulation of interferon-beta biosynthetic process (GO:0045357)3.08004180
109regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.07701801
110neutrophil chemotaxis (GO:0030593)3.06481827
111regulation of dendritic cell antigen processing and presentation (GO:0002604)3.04060666
112positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.02712653
113positive regulation of chemokine production (GO:0032722)3.02580764
114positive regulation of prostaglandin secretion (GO:0032308)3.02415636
115regulation of vitamin metabolic process (GO:0030656)3.01274000
116negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.99718839
117NIK/NF-kappaB signaling (GO:0038061)2.98516937
118neutrophil migration (GO:1990266)2.98403930
119regulation of mast cell degranulation (GO:0043304)2.95501173
120positive regulation of monocyte chemotaxis (GO:0090026)2.95216814
121positive regulation of T-helper cell differentiation (GO:0045624)2.95182760
122regulation of prostaglandin secretion (GO:0032306)2.94938715
123myeloid leukocyte activation (GO:0002274)2.94610363
124eosinophil chemotaxis (GO:0048245)2.93773850
125positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.93595643
126regulation of interleukin-6 biosynthetic process (GO:0045408)2.93487056
127positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.93452367
128positive regulation of antigen processing and presentation (GO:0002579)2.90129275
129response to interferon-beta (GO:0035456)2.88655779
130positive regulation of macrophage cytokine production (GO:0060907)2.87769621
131regulation of macrophage cytokine production (GO:0010935)2.87228482
132positive regulation of cellular amide metabolic process (GO:0034250)2.87187158
133antigen processing and presentation via MHC class Ib (GO:0002475)2.86067871
134regulation of interleukin-12 biosynthetic process (GO:0045075)2.85794735
135regulation of heterotypic cell-cell adhesion (GO:0034114)2.85360691
136negative regulation of cytokine production involved in immune response (GO:0002719)2.85163993
137negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.84210824
138positive regulation of acute inflammatory response (GO:0002675)2.83743306
139myeloid cell activation involved in immune response (GO:0002275)2.83440922
140positive regulation of mast cell degranulation (GO:0043306)2.81949493
141positive regulation of mast cell activation involved in immune response (GO:0033008)2.81949493
142positive regulation of interleukin-2 production (GO:0032743)2.80886831
143negative regulation of interleukin-17 production (GO:0032700)2.80304843
144regulation of mononuclear cell migration (GO:0071675)2.79987364
145negative regulation of immunoglobulin mediated immune response (GO:0002890)2.79507708
146negative regulation of B cell mediated immunity (GO:0002713)2.79507708
147positive regulation of NF-kappaB import into nucleus (GO:0042346)2.79434907
148JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.79239591
149regulation of mast cell activation (GO:0033003)2.79070472
150dendritic cell migration (GO:0036336)2.78951652
151response to protozoan (GO:0001562)2.77710610
152response to host immune response (GO:0052572)2.77567012
153response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.77567012
154growth hormone receptor signaling pathway (GO:0060396)2.77511689
155regulation of interleukin-12 production (GO:0032655)2.75679855
156B cell receptor signaling pathway (GO:0050853)2.75307496
157regulation of toll-like receptor signaling pathway (GO:0034121)2.75286699

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.14574353
2IRF8_21731497_ChIP-ChIP_J774_Mouse6.66900032
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.63172619
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.71141598
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.33209074
6* IRF8_27001747_Chip-Seq_BMDM_Mouse3.94925848
7* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.63269324
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.56052278
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.45530337
10* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.44626048
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.11284583
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.96964024
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.71089793
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.64402062
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.58658482
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.57304700
17* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.54992950
18PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.52097396
19MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.48545549
20STAT4_19710469_ChIP-ChIP_TH1__Mouse2.46805617
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.43042430
22STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.34381417
23NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.04643191
24ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.03987271
25TP63_17297297_ChIP-ChIP_HaCaT_Human1.97214203
26EGR1_23403033_ChIP-Seq_LIVER_Mouse1.86094950
27BRD4_27068464_Chip-Seq_AML-cells_Mouse1.81349165
28CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.79990107
29RXR_22158963_ChIP-Seq_LIVER_Mouse1.63810348
30BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.63210517
31* SPI1_23547873_ChIP-Seq_NB4_Human1.62875909
32PU_27001747_Chip-Seq_BMDM_Mouse1.55113780
33PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.54761334
34PPARA_22158963_ChIP-Seq_LIVER_Mouse1.54500694
35E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.53671451
36VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.51705697
37* LXR_22158963_ChIP-Seq_LIVER_Mouse1.50413354
38MYB_26560356_Chip-Seq_TH2_Human1.45953383
39CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.43720549
40TCF7_22412390_ChIP-Seq_EML_Mouse1.42658003
41UTX_26944678_Chip-Seq_JUKART_Human1.39858594
42TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37637413
43PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.35923090
44TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.35758335
45ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.34221403
46SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.32493705
47NRF2_20460467_ChIP-Seq_MEFs_Mouse1.32363278
48NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.32363278
49MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.31566287
50RUNX_20019798_ChIP-Seq_JUKART_Human1.30733966
51GATA1_19941827_ChIP-Seq_MEL_Mouse1.30708567
52VDR_24787735_ChIP-Seq_THP-1_Human1.28209625
53CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.24554329
54MAF_26560356_Chip-Seq_TH1_Human1.24284260
55CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23061603
56STAT6_21828071_ChIP-Seq_BEAS2B_Human1.21447063
57KDM2B_26808549_Chip-Seq_SUP-B15_Human1.18628222
58CLOCK_20551151_ChIP-Seq_293T_Human1.18435559
59VDR_24763502_ChIP-Seq_THP-1_Human1.18149991
60MYB_26560356_Chip-Seq_TH1_Human1.17904293
61RUNX1_22412390_ChIP-Seq_EML_Mouse1.17551791
62CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16631328
63SMAD_19615063_ChIP-ChIP_OVARY_Human1.15531640
64GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11230472
65CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.07800283
66CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07014079
67SPI1_23127762_ChIP-Seq_K562_Human1.06430424
68MAF_26560356_Chip-Seq_TH2_Human1.05604568
69GATA3_26560356_Chip-Seq_TH2_Human1.05290017
70SOX2_20726797_ChIP-Seq_SW620_Human1.05228111
71TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.05176722
72SCL_19346495_ChIP-Seq_HPC-7_Human1.03794496
73THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.03603631
74FOXO3_23340844_ChIP-Seq_DLD1_Human1.02101588
75LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.00992613
76FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.00528783
77TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99702093
78MYC_22102868_ChIP-Seq_BL_Human0.99494461
79KDM2B_26808549_Chip-Seq_DND41_Human0.99076435
80PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98308903
81RARG_19884340_ChIP-ChIP_MEFs_Mouse0.98006163
82GATA3_27048872_Chip-Seq_THYMUS_Human0.97713794
83GATA2_21666600_ChIP-Seq_HMVEC_Human0.97000597
84SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96029865
85GATA2_19941826_ChIP-Seq_K562_Human0.95797925
86GATA2_22383799_ChIP-Seq_G1ME_Mouse0.95175756
87STAT3_1855785_ChIP-Seq_MESCs_Mouse0.94765052
88KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.94455286
89SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.93121234
90SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.93121234
91RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.92587464
92GATA1_19941826_ChIP-Seq_K562_Human0.92049514
93SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.90960636
94FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.89879708
95KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.89762600
96GATA1_22383799_ChIP-Seq_G1ME_Mouse0.89486015
97TRIM28_21343339_ChIP-Seq_HEK293_Human0.89295168
98GATA1_22025678_ChIP-Seq_K562_Human0.89061055
99SALL4_18804426_ChIP-ChIP_XEN_Mouse0.88906785
100CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.88008195
101GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.87430279
102* FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.85511965
103E2F7_22180533_ChIP-Seq_HELA_Human0.85081849
104GATA1_19941827_ChIP-Seq_MEL86_Mouse0.84646273
105TFEB_21752829_ChIP-Seq_HELA_Human0.84380219
106* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.83767848
107* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.83097279
108NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.81882130
109BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.81479295
110* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.80527902
111PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.80236184
112HIF1A_21447827_ChIP-Seq_MCF-7_Human0.79392255
113EGR1_19032775_ChIP-ChIP_M12_Human0.79385196
114ESR1_20079471_ChIP-ChIP_T-47D_Human0.78220977
115SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.77875608
116SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.77750775
117RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.77730887
118* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.76949262
119VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.76490666
120SMRT_27268052_Chip-Seq_Bcells_Human0.74977646
121ELK3_25401928_ChIP-Seq_HUVEC_Human0.74010972
122ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.73828509
123FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.73427921
124GATA4_25053715_ChIP-Seq_YYC3_Human0.73266911
125JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.72331866
126FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.71834564
127CDX2_19796622_ChIP-Seq_MESCs_Mouse0.71479694
128KDM2B_26808549_Chip-Seq_JURKAT_Human0.71398316
129GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71260865
130ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.67309519
131JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.66676362
132CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.64984254
133LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.64934505
134VDR_21846776_ChIP-Seq_THP-1_Human0.64008527
135CJUN_26792858_Chip-Seq_BT549_Human0.63153285

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.39630606
2MP0009785_altered_susceptibility_to3.97637678
3MP0002148_abnormal_hypersensitivity_rea3.43042004
4MP0003436_decreased_susceptibility_to3.31281291
5MP0006082_CNS_inflammation3.11058933
6MP0003303_peritoneal_inflammation2.91394049
7MP0003724_increased_susceptibility_to2.84707100
8MP0005000_abnormal_immune_tolerance2.79119115
9MP0002419_abnormal_innate_immunity2.77784373
10MP0005025_abnormal_response_to2.75011743
11MP0004510_myositis2.54734290
12MP0005167_abnormal_blood-brain_barrier2.52510222
13MP0000685_abnormal_immune_system2.47315160
14MP0002006_tumorigenesis2.40947189
15MP0005387_immune_system_phenotype2.34846171
16MP0001790_abnormal_immune_system2.34846171
17MP0008260_abnormal_autophagy2.33971423
18MP0002452_abnormal_antigen_presenting2.26451685
19MP0009764_decreased_sensitivity_to2.18827512
20MP0002254_reproductive_system_inflammat2.16511126
21MP0005671_abnormal_response_to2.12847974
22MP0002723_abnormal_immune_serum2.12483508
23MP0003186_abnormal_redox_activity2.05995590
24MP0001800_abnormal_humoral_immune2.05789621
25MP0003448_altered_tumor_morphology2.04656048
26MP0005058_abnormal_lysosome_morphology2.00315222
27MP0001853_heart_inflammation1.89381293
28MP0001819_abnormal_immune_cell1.85171618
29MP0002420_abnormal_adaptive_immunity1.79684906
30MP0010352_gastrointestinal_tract_polyps1.79296354
31MP0002138_abnormal_hepatobiliary_system1.74755414
32MP0001845_abnormal_inflammatory_respons1.73971782
33MP0008469_abnormal_protein_level1.70728179
34MP0001533_abnormal_skeleton_physiology1.70318892
35MP0003191_abnormal_cellular_cholesterol1.64769686
36MP0004947_skin_inflammation1.62329185
37MP0002132_abnormal_respiratory_system1.60032207
38MP0000343_altered_response_to1.58891947
39MP0002405_respiratory_system_inflammati1.58755373
40MP0008004_abnormal_stomach_pH1.58390328
41MP0004883_abnormal_blood_vessel1.57502762
42MP0003763_abnormal_thymus_physiology1.53319923
43MP0010155_abnormal_intestine_physiology1.52811636
44MP0003195_calcinosis1.48703656
45MP0000858_altered_metastatic_potential1.47596410
46MP0009840_abnormal_foam_cell1.46682740
47MP0005310_abnormal_salivary_gland1.45462619
48MP0005464_abnormal_platelet_physiology1.44725047
49MP0003075_altered_response_to1.44344720
50MP0003656_abnormal_erythrocyte_physiolo1.43653176
51MP0002998_abnormal_bone_remodeling1.37991415
52MP0003300_gastrointestinal_ulcer1.34579822
53MP0009278_abnormal_bone_marrow1.33572799
54MP0000465_gastrointestinal_hemorrhage1.31472380
55MP0009333_abnormal_splenocyte_physiolog1.29474429
56MP0004782_abnormal_surfactant_physiolog1.28767151
57MP0002166_altered_tumor_susceptibility1.27303422
58MP0003646_muscle_fatigue1.27029800
59MP0005166_decreased_susceptibility_to1.25373456
60* MP0000716_abnormal_immune_system1.22293212
61MP0004381_abnormal_hair_follicle1.21021190
62MP0005164_abnormal_response_to1.19475140
63MP0003221_abnormal_cardiomyocyte_apopto1.17242886
64MP0002277_abnormal_respiratory_mucosa1.16092164
65MP0010307_abnormal_tumor_latency1.15802540
66MP0009763_increased_sensitivity_to1.15751033
67MP0001851_eye_inflammation1.15672645
68MP0003453_abnormal_keratinocyte_physiol1.15249243
69MP0003866_abnormal_defecation1.12653100
70MP0003690_abnormal_glial_cell1.07686927
71* MP0002398_abnormal_bone_marrow1.04827571
72MP0004130_abnormal_muscle_cell1.03957832
73MP0002332_abnormal_exercise_endurance1.02444936
74MP0005397_hematopoietic_system_phenotyp1.01772199
75MP0001545_abnormal_hematopoietic_system1.01772199
76MP0000604_amyloidosis1.01497733
77MP0003828_pulmonary_edema1.01273389
78MP0002396_abnormal_hematopoietic_system1.01139282
79MP0003566_abnormal_cell_adhesion0.99645202
80* MP0002429_abnormal_blood_cell0.95676393
81MP0005076_abnormal_cell_differentiation0.94971018
82* MP0000703_abnormal_thymus_morphology0.94601000
83MP0005319_abnormal_enzyme/_coenzyme0.94404105
84MP0003045_fibrosis0.94224819
85MP0003172_abnormal_lysosome_physiology0.93575249
86MP0002877_abnormal_melanocyte_morpholog0.92403378
87MP0004484_altered_response_of0.91250433
88MP0006054_spinal_hemorrhage0.90907794
89MP0003705_abnormal_hypodermis_morpholog0.90713755
90MP0003183_abnormal_peptide_metabolism0.90635402
91MP0004808_abnormal_hematopoietic_stem0.90372943
92MP0000371_diluted_coat_color0.89238958
93MP0002136_abnormal_kidney_physiology0.87906592
94MP0005535_abnormal_body_temperature0.87834515
95MP0001881_abnormal_mammary_gland0.87497985
96MP0000609_abnormal_liver_physiology0.87346949
97MP0000689_abnormal_spleen_morphology0.86033450
98MP0010234_abnormal_vibrissa_follicle0.85559569
99MP0003806_abnormal_nucleotide_metabolis0.83046118
100MP0009765_abnormal_xenobiotic_induced0.81810529
101* MP0002722_abnormal_immune_system0.81720092
102MP0000249_abnormal_blood_vessel0.80526561
103MP0005360_urolithiasis0.78983492
104MP0005408_hypopigmentation0.76954900
105MP0000372_irregular_coat_pigmentation0.76543080
106MP0002139_abnormal_hepatobiliary_system0.74174301
107MP0009643_abnormal_urine_homeostasis0.74069603
108MP0005584_abnormal_enzyme/coenzyme_acti0.72535169
109MP0001873_stomach_inflammation0.71151842
110MP0001663_abnormal_digestive_system0.70115381
111MP0000015_abnormal_ear_pigmentation0.68908428
112MP0008874_decreased_physiological_sensi0.68898717
113MP0000569_abnormal_digit_pigmentation0.68813011
114MP0003091_abnormal_cell_migration0.66475983
115MP0004185_abnormal_adipocyte_glucose0.66158779
116MP0005376_homeostasis/metabolism_phenot0.65969459
117MP0009115_abnormal_fat_cell0.65712267
118MP0005451_abnormal_body_composition0.64445351
119MP0005390_skeleton_phenotype0.63550657
120MP0008775_abnormal_heart_ventricle0.63214779
121MP0001348_abnormal_lacrimal_gland0.63176655
122MP0000598_abnormal_liver_morphology0.61611384
123MP0003795_abnormal_bone_structure0.61183838
124MP0002971_abnormal_brown_adipose0.60384646
125MP0003329_amyloid_beta_deposits0.52435926
126MP0005023_abnormal_wound_healing0.51350979

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)7.56858076
2Recurrent abscess formation (HP:0002722)6.42973646
3Recurrent bacterial skin infections (HP:0005406)6.01662455
4Recurrent gram-negative bacterial infections (HP:0005420)6.01645738
5Mediastinal lymphadenopathy (HP:0100721)5.07884075
6Autoimmune thrombocytopenia (HP:0001973)4.92772185
7Abnormality of macrophages (HP:0004311)4.89274355
8Keratoconjunctivitis sicca (HP:0001097)4.77603461
9Elevated erythrocyte sedimentation rate (HP:0003565)4.18335130
10Gingivitis (HP:0000230)4.08634671
11Recurrent skin infections (HP:0001581)3.86541687
12Tetraparesis (HP:0002273)3.83249892
13Increased IgM level (HP:0003496)3.78375345
14Recurrent fungal infections (HP:0002841)3.66204345
15Systemic lupus erythematosus (HP:0002725)3.58347451
16Peritonitis (HP:0002586)3.52934730
17Encephalitis (HP:0002383)3.50774509
18T lymphocytopenia (HP:0005403)3.48994215
19Vacuolated lymphocytes (HP:0001922)3.43136913
20Basal ganglia calcification (HP:0002135)3.35270726
21Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.33487485
22Vasculitis (HP:0002633)3.29116064
23Abnormal delayed hypersensitivity skin test (HP:0002963)3.28345234
24Spontaneous hematomas (HP:0007420)3.28067735
25Interstitial pulmonary disease (HP:0006530)3.26277359
26Axonal loss (HP:0003447)3.25772815
27Orchitis (HP:0100796)3.25403343
28Stomatitis (HP:0010280)3.23721812
29Myositis (HP:0100614)3.22885839
30Gangrene (HP:0100758)3.20969112
31Increased cerebral lipofuscin (HP:0011813)3.08926613
32Amyloidosis (HP:0011034)3.07532188
33Anorexia (HP:0002039)3.05564362
34Chest pain (HP:0100749)3.03808896
35Chronic obstructive pulmonary disease (HP:0006510)3.02141182
36Obstructive lung disease (HP:0006536)3.02141182
37Increased neuronal autofluorescent lipopigment (HP:0002074)2.98299625
38Episodic fever (HP:0001954)2.97751880
39Hematochezia (HP:0002573)2.91764504
40Cellulitis (HP:0100658)2.90678652
41Pulmonary embolism (HP:0002204)2.89955287
42Hydroxyprolinuria (HP:0003080)2.89541488
43Abnormality of proline metabolism (HP:0010907)2.89541488
44Increased IgE level (HP:0003212)2.87404021
45Recurrent viral infections (HP:0004429)2.86803436
46Chronic mucocutaneous candidiasis (HP:0002728)2.85306766
47Recurrent cutaneous fungal infections (HP:0011370)2.85306766
48Retrobulbar optic neuritis (HP:0100654)2.82558274
49Optic neuritis (HP:0100653)2.82558274
50Nausea (HP:0002018)2.80561704
51Periodontitis (HP:0000704)2.72954805
52Hypergammaglobulinemia (HP:0010702)2.72456782
53Prostate neoplasm (HP:0100787)2.68691583
54Subacute progressive viral hepatitis (HP:0006572)2.68028820
55Urticaria (HP:0001025)2.66830727
56Exercise-induced muscle cramps (HP:0003710)2.65003275
57Abnormality of the pleura (HP:0002103)2.62215006
58Myocardial infarction (HP:0001658)2.60876167
59Esophageal varix (HP:0002040)2.54381707
60Abnormality of the endocardium (HP:0004306)2.54173751
61Abnormality of the peritoneum (HP:0002585)2.53341132
62Recurrent pneumonia (HP:0006532)2.52277649
63Disinhibition (HP:0000734)2.49570738
64Autoimmune hemolytic anemia (HP:0001890)2.49427761
65Esophageal neoplasm (HP:0100751)2.49238050
66Neoplasm of head and neck (HP:0012288)2.49238050
67Abnormality of T cells (HP:0002843)2.48419711
68Osteomyelitis (HP:0002754)2.47895315
69Premature loss of primary teeth (HP:0006323)2.44341680
70Thick nail (HP:0001805)2.43287344
71Epistaxis (HP:0000421)2.42881756
72Abnormality of glutamine family amino acid metabolism (HP:0010902)2.42658404
73Keratitis (HP:0000491)2.40749056
74Pulmonary infiltrates (HP:0002113)2.39994098
75Glomerulopathy (HP:0100820)2.37123484
76Prolonged bleeding time (HP:0003010)2.36914737
77Glomerulonephritis (HP:0000099)2.31060551
78Porencephaly (HP:0002132)2.29606705
79Osteolytic defects of the phalanges of the hand (HP:0009771)2.28806467
80Osteolytic defects of the hand bones (HP:0009699)2.28806467
81Agnosia (HP:0010524)2.28620139
82Hepatosplenomegaly (HP:0001433)2.26239219
83Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.25868327
84Granulocytopenia (HP:0001913)2.24926786
85Gingival bleeding (HP:0000225)2.24619197
86Bone pain (HP:0002653)2.22272152
87Vertigo (HP:0002321)2.21606622
88Eosinophilia (HP:0001880)2.20711457
89Recurrent lower respiratory tract infections (HP:0002783)2.20663081
90Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.19610652
91Slow saccadic eye movements (HP:0000514)2.18863339
92Nephritis (HP:0000123)2.18205584
93Pathologic fracture (HP:0002756)2.15032873
94Hemorrhage of the eye (HP:0011885)2.14170941
95Chronic otitis media (HP:0000389)2.14038061
96Polyneuropathy (HP:0001271)2.13554594
97Hypoglycemic coma (HP:0001325)2.13531861
98Increased serum ferritin (HP:0003281)2.12060622
99Petechiae (HP:0000967)2.11332718
100Loss of speech (HP:0002371)2.09824868
101Acne (HP:0001061)2.09027286
102Inflammation of the large intestine (HP:0002037)2.08802410
103Gastrointestinal infarctions (HP:0005244)2.08792902
104Arterial thrombosis (HP:0004420)2.08369385
105Pustule (HP:0200039)2.08330711
106Sepsis (HP:0100806)2.06798422
107Joint swelling (HP:0001386)2.05969669
108Abnormality of the vasculature of the conjunctiva (HP:0008054)2.05583727
109Viral hepatitis (HP:0006562)2.05443545
110Abnormality of liposaccharide metabolism (HP:0010968)2.05389075
111Abnormality of glycosphingolipid metabolism (HP:0004343)2.05389075
112Abnormality of glycolipid metabolism (HP:0010969)2.05389075
113Abnormality of iron homeostasis (HP:0011031)2.04468409
114Acute hepatic failure (HP:0006554)2.03442676
115Leukocytosis (HP:0001974)2.03165559
116Thrombophlebitis (HP:0004418)2.02639024
117Mucosal telangiectasiae (HP:0100579)2.02248348
118Segmental peripheral demyelination/remyelination (HP:0003481)2.02125318
119Colitis (HP:0002583)2.00861582
120Hemoptysis (HP:0002105)2.00027635
121Abnormality of T cell number (HP:0011839)1.99580779
122Joint hemorrhage (HP:0005261)1.96688134
123Recurrent bronchitis (HP:0002837)1.95442381
124Gastrointestinal stroma tumor (HP:0100723)1.95013707
125Cheilitis (HP:0100825)1.94092528
126Neoplasm of the tracheobronchial system (HP:0100552)1.92555652
127Gastrointestinal inflammation (HP:0004386)1.92154479
128Parakeratosis (HP:0001036)1.91173594
129IgA deficiency (HP:0002720)1.90985530
130Hypochromic anemia (HP:0001931)1.90837576
131Abnormality of the pericardium (HP:0001697)1.90399708
132Abnormality of T cell physiology (HP:0011840)1.89351340
133Abnormality of the basal ganglia (HP:0002134)1.89172524
134Keratoconjunctivitis (HP:0001096)1.89093803
135Upper motor neuron abnormality (HP:0002127)1.88136467
136Meningitis (HP:0001287)1.88081306
137Purpura (HP:0000979)1.86600141
138Vertebral compression fractures (HP:0002953)1.85941299
139Prolonged neonatal jaundice (HP:0006579)1.84857620
140Poor head control (HP:0002421)1.84057259
141Bone cyst (HP:0012062)1.83799022
142Abnormality of transition element cation homeostasis (HP:0011030)1.83733377
143Skin ulcer (HP:0200042)1.83664364
144Progressive visual loss (HP:0000529)1.83229023
145Proximal tubulopathy (HP:0000114)1.82000562
146Fatigue (HP:0012378)1.81336891
147Hypochromic microcytic anemia (HP:0004840)1.80596654
148Amaurosis fugax (HP:0100576)1.78300393
149Abnormality of eosinophils (HP:0001879)1.77544297
150Alveolar cell carcinoma (HP:0006519)1.74817767

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K145.25012011
2PBK5.19011772
3TBK13.70028692
4RIPK43.48608151
5TYK22.92295965
6BLK2.86126343
7IRAK32.64670311
8IRAK42.55443035
9IKBKE2.55235267
10JAK32.53101531
11IKBKB2.40734661
12EPHB12.14041722
13MST42.12782045
14EPHA32.04565679
15JAK12.02662530
16CHUK1.84164768
17FES1.80117076
18FGFR41.71833307
19PRPF4B1.68633060
20TXK1.67957612
21BMX1.67773131
22GRK61.63187416
23MST1R1.60532777
24FGFR31.57721994
25MAP3K131.56848570
26ERN11.55352654
27TAOK11.53016736
28MAP3K21.52954871
29PIM21.51518922
30TAOK31.50492115
31MAP4K11.47993115
32SIK31.44655892
33ABL21.38895106
34RPS6KA41.33664783
35KIT1.31885643
36NEK91.31650629
37PIM11.30307809
38STK41.28196179
39JAK21.26671649
40MAP3K61.26256386
41MET1.16814397
42CSK1.14464003
43TTN1.12302050
44TNK21.11503152
45FGR1.10928791
46MAP3K111.08957887
47RIPK11.07304687
48GRK71.04770704
49TAOK21.03799315
50ZAP701.03735705
51NLK1.03352810
52BMPR21.02303539
53KSR11.01534355
54IRAK11.00965019
55SYK0.98259682
56HCK0.97941558
57ERBB40.90497334
58CSF1R0.85860731
59EIF2AK20.82868069
60MARK30.82484660
61WNK10.82114711
62RAF10.80649616
63TRPM70.77258798
64FLT30.77110255
65FRK0.74405241
66LYN0.71251429
67NME20.71163071
68MAP3K50.70728675
69LCK0.70646965
70KDR0.70469696
71MARK20.68590144
72STK100.67591473
73SGK30.67577702
74BTK0.67212768
75PKN20.66249559
76MATK0.66134825
77ABL10.63926559
78PTK60.63860156
79ERBB30.63490467
80EGFR0.62903536
81CDC42BPA0.62852216
82MAP2K60.62135053
83CLK10.61369364
84TEC0.59846583
85BCR0.58941879
86MOS0.58840902
87PRKCD0.57633099
88LRRK20.57624073
89STK240.57092591
90YES10.55256331
91MAP2K40.55150700
92PDK20.54740058
93TGFBR20.54430675
94SGK20.53655150
95DYRK30.53509856
96ALK0.52021249
97FYN0.51484216
98CDK60.49311262
99STK30.48753481
100PIK3CG0.48576401
101BCKDK0.44980181
102MAP2K30.44251354
103RPS6KA50.43589596
104HIPK20.42908783
105PRKCQ0.42034870
106RET0.41767089
107STK380.40512109
108GSK3A0.38174894
109MAPK70.37476215
110MAPKAPK20.37081209
111ITK0.35285738
112MAP3K30.35114080
113STK110.34939663
114PDPK10.34887674
115CDK120.34439977
116TGFBR10.33897603
117CDK40.33602862
118MAP3K10.33031306
119PRKD20.32748021
120PDK10.32462627
121PDGFRB0.31165312
122MAP3K70.31158895
123ARAF0.31101292
124CAMKK20.29354241
125KSR20.28762120
126DAPK30.28660584
127IGF1R0.28054352
128INSR0.27847682
129DYRK1B0.27706048
130DAPK20.27295582
131ACVR1B0.27149807
132PRKAA20.26352195
133RPS6KA10.25415576
134MAPK120.25411551
135PTK2B0.23779921
136IRAK20.22582277
137MAP3K80.21772659
138SCYL20.18591124

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053324.21472586
2Leishmaniasis_Homo sapiens_hsa051403.29376633
3Allograft rejection_Homo sapiens_hsa053302.81274297
4Toll-like receptor signaling pathway_Homo sapiens_hsa046202.79816625
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.78068261
6Staphylococcus aureus infection_Homo sapiens_hsa051502.77171333
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.71772136
8Legionellosis_Homo sapiens_hsa051342.69486720
9Type I diabetes mellitus_Homo sapiens_hsa049402.69317190
10NOD-like receptor signaling pathway_Homo sapiens_hsa046212.67707215
11Rheumatoid arthritis_Homo sapiens_hsa053232.32032131
12RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.26815329
13Osteoclast differentiation_Homo sapiens_hsa043802.17647638
14Pertussis_Homo sapiens_hsa051332.13092251
15Measles_Homo sapiens_hsa051622.12241561
16Malaria_Homo sapiens_hsa051442.01366256
17Tuberculosis_Homo sapiens_hsa051521.97958997
18Asthma_Homo sapiens_hsa053101.97057965
19TNF signaling pathway_Homo sapiens_hsa046681.89719873
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.89101279
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.87115070
22African trypanosomiasis_Homo sapiens_hsa051431.83128627
23Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.81012572
24Influenza A_Homo sapiens_hsa051641.80578987
25Salmonella infection_Homo sapiens_hsa051321.59829251
26Herpes simplex infection_Homo sapiens_hsa051681.56978118
27Toxoplasmosis_Homo sapiens_hsa051451.51894249
28Phagosome_Homo sapiens_hsa041451.36233349
29Autoimmune thyroid disease_Homo sapiens_hsa053201.35085704
30Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.31770203
31Lysosome_Homo sapiens_hsa041421.24604191
32Non-small cell lung cancer_Homo sapiens_hsa052231.14673199
33Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.13535036
34Apoptosis_Homo sapiens_hsa042101.13520049
35Jak-STAT signaling pathway_Homo sapiens_hsa046301.10689203
36Chemokine signaling pathway_Homo sapiens_hsa040621.08323595
37Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.08101611
38Pentose and glucuronate interconversions_Homo sapiens_hsa000401.07229284
39Antigen processing and presentation_Homo sapiens_hsa046121.07160163
40Hematopoietic cell lineage_Homo sapiens_hsa046401.06221696
41Viral myocarditis_Homo sapiens_hsa054161.04606083
42Hepatitis C_Homo sapiens_hsa051601.03120428
43Dorso-ventral axis formation_Homo sapiens_hsa043201.02475104
44Prion diseases_Homo sapiens_hsa050201.01571796
45Arginine biosynthesis_Homo sapiens_hsa002201.01351868
46VEGF signaling pathway_Homo sapiens_hsa043700.99185897
47B cell receptor signaling pathway_Homo sapiens_hsa046620.98550897
48Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.97302566
49Renal cell carcinoma_Homo sapiens_hsa052110.95894201
50Adipocytokine signaling pathway_Homo sapiens_hsa049200.94856134
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.92742960
52AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.92047166
53Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.89439425
54Amoebiasis_Homo sapiens_hsa051460.89182996
55Platelet activation_Homo sapiens_hsa046110.88287966
56Shigellosis_Homo sapiens_hsa051310.84613107
57FoxO signaling pathway_Homo sapiens_hsa040680.84104075
58Complement and coagulation cascades_Homo sapiens_hsa046100.75824637
59Hepatitis B_Homo sapiens_hsa051610.75816386
60Sphingolipid signaling pathway_Homo sapiens_hsa040710.70741100
61Caffeine metabolism_Homo sapiens_hsa002320.68702752
62PPAR signaling pathway_Homo sapiens_hsa033200.66855400
63Collecting duct acid secretion_Homo sapiens_hsa049660.65657117
64Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.64285044
65HIF-1 signaling pathway_Homo sapiens_hsa040660.63018707
66SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62363641
67Leukocyte transendothelial migration_Homo sapiens_hsa046700.61016318
68Endometrial cancer_Homo sapiens_hsa052130.60690204
69Acute myeloid leukemia_Homo sapiens_hsa052210.58056145
70Fatty acid degradation_Homo sapiens_hsa000710.57674630
71Type II diabetes mellitus_Homo sapiens_hsa049300.57362976
72Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57317473
73Insulin resistance_Homo sapiens_hsa049310.56264015
74Primary immunodeficiency_Homo sapiens_hsa053400.54256569
75GnRH signaling pathway_Homo sapiens_hsa049120.53913491
76Endocytosis_Homo sapiens_hsa041440.53881587
77Notch signaling pathway_Homo sapiens_hsa043300.53876292
78Phenylalanine metabolism_Homo sapiens_hsa003600.53445332
79Mineral absorption_Homo sapiens_hsa049780.53012715
80mTOR signaling pathway_Homo sapiens_hsa041500.52785896
81Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.52574224
82Steroid biosynthesis_Homo sapiens_hsa001000.52190218
83Peroxisome_Homo sapiens_hsa041460.51564024
84Bladder cancer_Homo sapiens_hsa052190.51060315
85ErbB signaling pathway_Homo sapiens_hsa040120.50567527
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.49595086
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49436020
88Prostate cancer_Homo sapiens_hsa052150.48007544
89Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47985573
90Glycosaminoglycan degradation_Homo sapiens_hsa005310.47698283
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46817638
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45908780
93MAPK signaling pathway_Homo sapiens_hsa040100.44863186
94Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44019949
952-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.42992091
96Choline metabolism in cancer_Homo sapiens_hsa052310.42564284
97Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42340334
98Inositol phosphate metabolism_Homo sapiens_hsa005620.42339697
99Small cell lung cancer_Homo sapiens_hsa052220.41226802
100Tryptophan metabolism_Homo sapiens_hsa003800.41121157
101Prolactin signaling pathway_Homo sapiens_hsa049170.41054801
102Histidine metabolism_Homo sapiens_hsa003400.40115489
103beta-Alanine metabolism_Homo sapiens_hsa004100.38338918
104HTLV-I infection_Homo sapiens_hsa051660.38283884
105Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.37344105
106Glioma_Homo sapiens_hsa052140.36029776
107Primary bile acid biosynthesis_Homo sapiens_hsa001200.35285653
108Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.35098668
109Epstein-Barr virus infection_Homo sapiens_hsa051690.34860881
110Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34493649
111Proteoglycans in cancer_Homo sapiens_hsa052050.34117834
112T cell receptor signaling pathway_Homo sapiens_hsa046600.34069108
113Propanoate metabolism_Homo sapiens_hsa006400.34062171
114Starch and sucrose metabolism_Homo sapiens_hsa005000.34051728
115Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.34013508
116Selenocompound metabolism_Homo sapiens_hsa004500.33957473
117Chronic myeloid leukemia_Homo sapiens_hsa052200.33718396
118Other glycan degradation_Homo sapiens_hsa005110.32856561
119Viral carcinogenesis_Homo sapiens_hsa052030.31860136
120Pancreatic cancer_Homo sapiens_hsa052120.31496028
121Fatty acid biosynthesis_Homo sapiens_hsa000610.31105520
122Carbon metabolism_Homo sapiens_hsa012000.31034012
123Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.30391668
124* Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29583436
125Proteasome_Homo sapiens_hsa030500.29488743
126Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.25234533
127Fatty acid metabolism_Homo sapiens_hsa012120.24606161
128Pentose phosphate pathway_Homo sapiens_hsa000300.24429603
129Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.22751963
130Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.21574367
131Transcriptional misregulation in cancer_Homo sapiens_hsa052020.19235020
132Neurotrophin signaling pathway_Homo sapiens_hsa047220.18234666

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