NANOG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a DNA binding homeobox transcription factor involved in embryonic stem (ES) cell proliferation, renewal, and pluripotency. The encoded protein can block ES cell differentiation and can also autorepress its own expression in differentiating cells. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1aminoglycoside antibiotic metabolic process (GO:0030647)6.94960332
2maintenance of protein location in nucleus (GO:0051457)6.93630328
3regulation of nuclear cell cycle DNA replication (GO:0033262)6.90344887
4regulation of telomere maintenance via telomerase (GO:0032210)6.56707122
5protein localization to kinetochore (GO:0034501)6.53014220
6negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)6.28013043
7negative regulation of telomerase activity (GO:0051974)6.24482646
8histone H4-K12 acetylation (GO:0043983)6.02323269
9somite rostral/caudal axis specification (GO:0032525)5.92643562
10regulation of mammary gland epithelial cell proliferation (GO:0033599)5.72613639
11negative regulation of epidermis development (GO:0045683)5.62745190
12negative regulation of cell cycle G2/M phase transition (GO:1902750)5.61924189
13histone H4-K5 acetylation (GO:0043981)5.57971654
14histone H4-K8 acetylation (GO:0043982)5.57971654
15mitotic sister chromatid segregation (GO:0000070)5.43987550
16regulation of MHC class I biosynthetic process (GO:0045343)5.10706869
17regulation of response to osmotic stress (GO:0047484)5.08703078
18rRNA transcription (GO:0009303)5.06518171
19positive regulation of DNA-dependent DNA replication (GO:2000105)4.96338504
20negative regulation of telomere maintenance (GO:0032205)4.90150067
21negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.86842396
22notochord development (GO:0030903)4.86186999
23protein localization to chromosome, centromeric region (GO:0071459)4.84269889
24muscle organ morphogenesis (GO:0048644)4.82062987
25DNA replication-dependent nucleosome organization (GO:0034723)4.80749656
26DNA replication-dependent nucleosome assembly (GO:0006335)4.80749656
27nuclear pore complex assembly (GO:0051292)4.77216934
28heterochromatin organization (GO:0070828)4.74549882
29regulation of translation in response to stress (GO:0043555)4.66098966
30DNA replication checkpoint (GO:0000076)4.63899181
31regulation of cilium movement (GO:0003352)4.56898803
32sister chromatid segregation (GO:0000819)4.50136691
33rRNA methylation (GO:0031167)4.49728719
34negative regulation of epidermal cell differentiation (GO:0045605)4.39203498
35nuclear pore organization (GO:0006999)4.36242148
36chromatin remodeling at centromere (GO:0031055)4.33992885
37rRNA modification (GO:0000154)4.32005791
38negative regulation of DNA-dependent DNA replication (GO:2000104)4.29383641
39regulation of apoptotic process involved in morphogenesis (GO:1902337)4.28945720
40nucleoside transmembrane transport (GO:1901642)4.28636804
41response to dietary excess (GO:0002021)4.27624656
42regulation of mitotic spindle checkpoint (GO:1903504)4.19176221
43regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.19176221
44intestinal epithelial cell development (GO:0060576)4.15521653
45DNA double-strand break processing (GO:0000729)4.13242126
46regulation of telomere maintenance (GO:0032204)4.11052089
47chromatin assembly (GO:0031497)4.10593051
48histone H4-K16 acetylation (GO:0043984)4.06223565
49CENP-A containing nucleosome assembly (GO:0034080)4.05528594
50branching involved in mammary gland duct morphogenesis (GO:0060444)3.98458629
51quinone metabolic process (GO:1901661)3.96486265
52regulation of telomerase activity (GO:0051972)3.94250572
53somatic diversification of immune receptors via somatic mutation (GO:0002566)3.93017267
54somatic hypermutation of immunoglobulin genes (GO:0016446)3.93017267
55cytidine metabolic process (GO:0046087)3.91990632
56cytidine catabolic process (GO:0006216)3.91990632
57cytidine deamination (GO:0009972)3.91990632
58primitive streak formation (GO:0090009)3.90281513
59intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)3.82359217
60pre-miRNA processing (GO:0031054)3.81743949
61histone exchange (GO:0043486)3.81478415
62phenol-containing compound catabolic process (GO:0019336)3.81010038
63coenzyme catabolic process (GO:0009109)3.78866346
64regulation of gene silencing by RNA (GO:0060966)3.77606896
65regulation of posttranscriptional gene silencing (GO:0060147)3.77606896
66regulation of gene silencing by miRNA (GO:0060964)3.77606896
67negative regulation of translation, ncRNA-mediated (GO:0040033)3.75992087
68regulation of translation, ncRNA-mediated (GO:0045974)3.75992087
69negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.75992087
70regulation of helicase activity (GO:0051095)3.75707151
71cardiovascular system development (GO:0072358)3.74331413
72maintenance of protein localization in organelle (GO:0072595)3.72707809
73cullin deneddylation (GO:0010388)3.72620218
74interferon-gamma production (GO:0032609)3.72097412
75formation of translation preinitiation complex (GO:0001731)3.70318736
76IMP biosynthetic process (GO:0006188)3.63554234
77hormone catabolic process (GO:0042447)3.61974035
78ribosome biogenesis (GO:0042254)3.59754565
79pore complex assembly (GO:0046931)3.57860747
80L-serine metabolic process (GO:0006563)3.56098762
81mitochondrion distribution (GO:0048311)3.52524088
82DNA duplex unwinding (GO:0032508)3.44641961
83DNA damage response, detection of DNA damage (GO:0042769)3.44635483
84nucleobase biosynthetic process (GO:0046112)3.41183985
85DNA geometric change (GO:0032392)3.40911791
86regulation of meiosis I (GO:0060631)3.37694993
87purine nucleobase biosynthetic process (GO:0009113)3.36574169
88cellular modified amino acid catabolic process (GO:0042219)3.33589931
89regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.33495282
90establishment of integrated proviral latency (GO:0075713)3.32666477
91mRNA stabilization (GO:0048255)3.32201230
92RNA stabilization (GO:0043489)3.32201230
93water-soluble vitamin biosynthetic process (GO:0042364)3.26899009
94retinoic acid receptor signaling pathway (GO:0048384)3.26554893
95microtubule severing (GO:0051013)3.26372680
96positive regulation of protein deacetylation (GO:0090312)3.26299305
97negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.25880910
98telomere maintenance via telomerase (GO:0007004)3.25550454
99mitochondrial RNA metabolic process (GO:0000959)3.25076855
100respiratory chain complex IV assembly (GO:0008535)3.23086559
101DNA replication-independent nucleosome assembly (GO:0006336)3.22668720
102DNA replication-independent nucleosome organization (GO:0034724)3.22668720
103regulation of DNA-dependent DNA replication (GO:0090329)3.21773260
104protein deneddylation (GO:0000338)3.21615423
105establishment of protein localization to mitochondrial membrane (GO:0090151)3.19806823
106transcription from mitochondrial promoter (GO:0006390)3.19330312
107proteasome assembly (GO:0043248)3.17817421
108regulation of centriole replication (GO:0046599)3.17518108
109protein polyglutamylation (GO:0018095)3.17242167
110IMP metabolic process (GO:0046040)3.17227812
111GDP-mannose metabolic process (GO:0019673)3.16773808
112bone trabecula formation (GO:0060346)3.16761668
113somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.16288925
114somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.16288925
115isotype switching (GO:0045190)3.16288925
116intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)3.16221187
117nucleoside transport (GO:0015858)3.15338247
118synapsis (GO:0007129)3.15269454
119RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.15194245
120lysine catabolic process (GO:0006554)3.15162882
121lysine metabolic process (GO:0006553)3.15162882
122trophectodermal cell differentiation (GO:0001829)3.13514281
123mitotic chromosome condensation (GO:0007076)3.13466051
124exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.11215847
125regulation of double-strand break repair (GO:2000779)3.10022831
126DNA unwinding involved in DNA replication (GO:0006268)3.09874822
127DNA catabolic process, exonucleolytic (GO:0000738)3.08967901
128termination of RNA polymerase III transcription (GO:0006386)3.08676043
129transcription elongation from RNA polymerase III promoter (GO:0006385)3.08676043
130nodal signaling pathway (GO:0038092)3.07677150
131spindle assembly (GO:0051225)3.07625193
132anterior/posterior axis specification (GO:0009948)3.05586765
133nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.04514620
134pseudouridine synthesis (GO:0001522)3.04456539
135maternal placenta development (GO:0001893)3.04374972
136negative regulation of DNA biosynthetic process (GO:2000279)3.03758850
137DNA strand elongation involved in DNA replication (GO:0006271)3.03667476
138maturation of 5.8S rRNA (GO:0000460)3.02327585
139regulation of microtubule-based movement (GO:0060632)3.01856968
140negative regulation of mitotic sister chromatid separation (GO:2000816)3.01451656
141negative regulation of sister chromatid segregation (GO:0033046)3.01451656
142negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.01451656
143negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.01451656
144negative regulation of mitotic sister chromatid segregation (GO:0033048)3.01451656
145chaperone-mediated protein transport (GO:0072321)2.99944779
146replication fork processing (GO:0031297)2.99520795
147mitochondrial DNA replication (GO:0006264)2.98559757
148negative regulation of chromosome segregation (GO:0051985)2.98540158
149negative regulation of gene silencing (GO:0060969)2.96901064
150negative regulation of DNA recombination (GO:0045910)2.94016780
151positive regulation of SMAD protein import into nucleus (GO:0060391)2.90061583
152protein neddylation (GO:0045116)2.86805494
153ncRNA catabolic process (GO:0034661)2.85384628
154regulation of mesoderm development (GO:2000380)2.85172508
155DNA strand elongation (GO:0022616)2.85059825
156mitotic metaphase plate congression (GO:0007080)2.83406707
157lung-associated mesenchyme development (GO:0060484)2.82039577
158regulation of gene silencing (GO:0060968)2.81397276
159ribosome assembly (GO:0042255)2.80658217
160tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.80373150
161RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.80373150
162mitotic spindle checkpoint (GO:0071174)2.77559517
163somatic recombination of immunoglobulin gene segments (GO:0016447)2.76727452
164spindle checkpoint (GO:0031577)2.75811876
165somatic diversification of immunoglobulins (GO:0016445)2.71804964
166single strand break repair (GO:0000012)2.71723813
167recombinational repair (GO:0000725)2.71518182
168cytochrome complex assembly (GO:0017004)2.69716537
169double-strand break repair via homologous recombination (GO:0000724)2.69612831
170intra-S DNA damage checkpoint (GO:0031573)2.68063486
171DNA deamination (GO:0045006)2.66870399
172response to X-ray (GO:0010165)2.66316678
173DNA strand renaturation (GO:0000733)2.65387465
174female gonad development (GO:0008585)2.64423685
175telomere maintenance via semi-conservative replication (GO:0032201)2.63457309
176kidney morphogenesis (GO:0060993)2.62703524
177histone mRNA metabolic process (GO:0008334)2.61074920
178regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.60507179
179regulation of mitotic metaphase/anaphase transition (GO:0030071)2.60507179
180polyketide metabolic process (GO:0030638)10.7329140
181doxorubicin metabolic process (GO:0044598)10.7329140
182daunorubicin metabolic process (GO:0044597)10.7329140

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.91476246
2* KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.91476246
3* KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.91476246
4BP1_19119308_ChIP-ChIP_Hs578T_Human5.55874931
5E2F7_22180533_ChIP-Seq_HELA_Human5.31073278
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.27057445
7* NACC1_18358816_ChIP-ChIP_MESCs_Mouse3.54882490
8POU5F1_18700969_ChIP-ChIP_MESCs_Mouse3.43337388
9SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.32377689
10ZNF274_21170338_ChIP-Seq_K562_Hela3.19616598
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.15449107
12GABP_17652178_ChIP-ChIP_JURKAT_Human3.03087825
13TP63_19390658_ChIP-ChIP_HaCaT_Human3.00889479
14* SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.99602988
15NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.93695320
16* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.83157653
17TCF3_18692474_ChIP-Seq_MEFs_Mouse2.80194142
18VDR_22108803_ChIP-Seq_LS180_Human2.75153829
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.72515679
20* TCF3_18692474_ChIP-Seq_MESCs_Mouse2.71686533
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.60694227
22FLI1_27457419_Chip-Seq_LIVER_Mouse2.37567759
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.34296851
24FOXM1_23109430_ChIP-Seq_U2OS_Human2.31508838
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.28417934
26* NANOG_18358816_ChIP-ChIP_MESCs_Mouse2.21555492
27MYC_18555785_ChIP-Seq_MESCs_Mouse2.19566621
28ELK1_19687146_ChIP-ChIP_HELA_Human2.15112787
29MYC_19079543_ChIP-ChIP_MESCs_Mouse2.11095579
30EWS_26573619_Chip-Seq_HEK293_Human2.09382403
31NANOG_18555785_ChIP-Seq_MESCs_Mouse2.05145798
32* NANOG_18347094_ChIP-ChIP_MESCs_Mouse2.04514568
33ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.03268572
34* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.95858812
35TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.92410150
36FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.91567442
37* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.88889568
38IRF1_19129219_ChIP-ChIP_H3396_Human1.88288082
39* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.85728402
40CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.85620632
41* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.84312178
42* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.83853426
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.82418960
44HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.81560163
45* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.81070363
46MYC_18940864_ChIP-ChIP_HL60_Human1.80791404
47FUS_26573619_Chip-Seq_HEK293_Human1.79525253
48VDR_23849224_ChIP-Seq_CD4+_Human1.78446371
49MYC_19030024_ChIP-ChIP_MESCs_Mouse1.78274545
50SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.77282311
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.77085009
52P300_19829295_ChIP-Seq_ESCs_Human1.70156630
53* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.68154985
54* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.67699900
55* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.66331184
56RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63354431
57IGF1R_20145208_ChIP-Seq_DFB_Human1.62959304
58* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.62932931
59GBX2_23144817_ChIP-Seq_PC3_Human1.59671406
60* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.56836147
61HIF1A_21447827_ChIP-Seq_MCF-7_Human1.51463003
62* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.51035029
63MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.50986105
64MYC_18358816_ChIP-ChIP_MESCs_Mouse1.50114927
65EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.49440649
66OCT4_18692474_ChIP-Seq_MEFs_Mouse1.49086603
67YY1_21170310_ChIP-Seq_MESCs_Mouse1.45919725
68* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.43521134
69PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.42742722
70CREB1_15753290_ChIP-ChIP_HEK293T_Human1.42473543
71* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.41526263
72* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.39749416
73FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.38773082
74POU3F2_20337985_ChIP-ChIP_501MEL_Human1.38257304
75PADI4_21655091_ChIP-ChIP_MCF-7_Human1.37531614
76KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.36826849
77ZFP57_27257070_Chip-Seq_ESCs_Mouse1.34939380
78TAF15_26573619_Chip-Seq_HEK293_Human1.34234935
79* NANOG_16518401_ChIP-PET_MESCs_Mouse1.29280941
80ZFP281_18757296_ChIP-ChIP_E14_Mouse1.29226077
81YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28616622
82KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.28042317
83PCGF2_27294783_Chip-Seq_NPCs_Mouse1.26776036
84GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.26550251
85E2F1_17053090_ChIP-ChIP_MCF-7_Human1.26250661
86E2F1_21310950_ChIP-Seq_MCF-7_Human1.25655028
87SRF_21415370_ChIP-Seq_HL-1_Mouse1.25338965
88TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23290468
89EST1_17652178_ChIP-ChIP_JURKAT_Human1.22972759
90PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21884377
91CTBP1_25329375_ChIP-Seq_LNCAP_Human1.21164534
92NANOG_21062744_ChIP-ChIP_HESCs_Human1.20982432
93CTBP2_25329375_ChIP-Seq_LNCAP_Human1.20722107
94EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.20488344
95ZFP281_27345836_Chip-Seq_ESCs_Mouse1.19985588
96MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.09449948
97KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.08761213
98THAP11_20581084_ChIP-Seq_MESCs_Mouse1.08309844
99E2F1_18555785_ChIP-Seq_MESCs_Mouse1.08185069
100TP53_22573176_ChIP-Seq_HFKS_Human1.08048735
101* NANOG_16153702_ChIP-ChIP_HESCs_Human1.07535634
102NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.06028784
103* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.05621368
104* NANOG_19829295_ChIP-Seq_ESCs_Human1.02794964
105* SOX2_19829295_ChIP-Seq_ESCs_Human1.02794964
106MYC_22102868_ChIP-Seq_BL_Human1.02117050
107PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.99815722
108ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.98991052
109RBPJ_22232070_ChIP-Seq_NCS_Mouse0.98899756
110NFE2_27457419_Chip-Seq_LIVER_Mouse0.98563106
111DCP1A_22483619_ChIP-Seq_HELA_Human0.98334705
112EZH2_27294783_Chip-Seq_NPCs_Mouse0.97973618
113GABP_19822575_ChIP-Seq_HepG2_Human0.97892488
114SUZ12_27294783_Chip-Seq_NPCs_Mouse0.95294635
115UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95202756
116CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.94580085
117HOXB4_20404135_ChIP-ChIP_EML_Mouse0.94288474
118ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93770541
119CDX2_20551321_ChIP-Seq_CACO-2_Human0.93682823
120FOXA1_25329375_ChIP-Seq_VCAP_Human0.93553240
121FOXA1_27270436_Chip-Seq_PROSTATE_Human0.93553240
122* KAP1_27257070_Chip-Seq_ESCs_Mouse0.93111365
123NOTCH1_21737748_ChIP-Seq_TLL_Human0.92531969
124HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.92139178
125* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90545241
126* POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90545241
127GATA1_26923725_Chip-Seq_HPCs_Mouse0.89379701
128KLF5_20875108_ChIP-Seq_MESCs_Mouse0.88987280
129TBX3_20139965_ChIP-Seq_ESCs_Mouse0.88691100
130TBX3_20139965_ChIP-Seq_MESCs_Mouse0.87673015
131NELFA_20434984_ChIP-Seq_ESCs_Mouse0.86811390
132* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.86369189
133TP53_22127205_ChIP-Seq_IMR90_Human0.86236235
134ETS1_20019798_ChIP-Seq_JURKAT_Human0.83810821
135XRN2_22483619_ChIP-Seq_HELA_Human0.83762568
136FOXP3_21729870_ChIP-Seq_TREG_Human0.83595255
137NCOR1_26117541_ChIP-Seq_K562_Human0.82981910
138AR_21909140_ChIP-Seq_LNCAP_Human0.82216982
139* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.78384057
140JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.78379888
141KDM5A_27292631_Chip-Seq_BREAST_Human0.78314513
142STAT3_18555785_ChIP-Seq_MESCs_Mouse0.77234678
143SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.76104212
144* SOX2_16153702_ChIP-ChIP_HESCs_Human0.74963191
145* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.74347080
146* POU5F1_16153702_ChIP-ChIP_HESCs_Human0.74052949
147YY1_22570637_ChIP-Seq_MALME-3M_Human0.73780091
148SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.69086235
149STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.68276210
150TTF2_22483619_ChIP-Seq_HELA_Human0.67100293
151TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.66393243
152* SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.65659045
153HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.64425068
154SRY_22984422_ChIP-ChIP_TESTIS_Rat0.63807016
155* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.63295075
156CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.62953212
157SALL1_21062744_ChIP-ChIP_HESCs_Human0.61361712

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation4.39913394
2MP0003011_delayed_dark_adaptation4.39245020
3MP0002254_reproductive_system_inflammat4.31065493
4MP0004264_abnormal_extraembryonic_tissu4.13038044
5MP0006292_abnormal_olfactory_placode4.11999578
6MP0008057_abnormal_DNA_replication3.82843729
7MP0003890_abnormal_embryonic-extraembry3.67148741
8MP0005075_abnormal_melanosome_morpholog3.29072103
9MP0004858_abnormal_nervous_system3.03653582
10MP0003941_abnormal_skin_development2.97480835
11MP0005499_abnormal_olfactory_system2.93512868
12MP0005394_taste/olfaction_phenotype2.93512868
13* MP0004957_abnormal_blastocyst_morpholog2.80799826
14MP0003718_maternal_effect2.79584458
15MP0002332_abnormal_exercise_endurance2.73353652
16MP0003122_maternal_imprinting2.56994993
17MP0003121_genomic_imprinting2.44654108
18MP0002653_abnormal_ependyma_morphology2.39985117
19MP0003705_abnormal_hypodermis_morpholog2.35880822
20MP0005257_abnormal_intraocular_pressure2.28880051
21MP0006035_abnormal_mitochondrial_morpho2.16436758
22MP0010352_gastrointestinal_tract_polyps2.14883203
23MP0002102_abnormal_ear_morphology2.09883464
24MP0001672_abnormal_embryogenesis/_devel2.04413078
25MP0005380_embryogenesis_phenotype2.04413078
26MP0003567_abnormal_fetal_cardiomyocyte1.95534569
27MP0004133_heterotaxia1.93163897
28MP0001188_hyperpigmentation1.90301482
29MP0003938_abnormal_ear_development1.90031529
30MP0006072_abnormal_retinal_apoptosis1.87294111
31MP0003077_abnormal_cell_cycle1.86090227
32MP0002088_abnormal_embryonic_growth/wei1.84977799
33MP0003123_paternal_imprinting1.84757892
34MP0003984_embryonic_growth_retardation1.83803359
35MP0000678_abnormal_parathyroid_gland1.77865731
36MP0003195_calcinosis1.76626723
37MP0003646_muscle_fatigue1.74319329
38MP0000350_abnormal_cell_proliferation1.73598599
39MP0003111_abnormal_nucleus_morphology1.71164528
40MP0001293_anophthalmia1.66144392
41MP0002127_abnormal_cardiovascular_syste1.64071082
42MP0002938_white_spotting1.60180224
43MP0002277_abnormal_respiratory_mucosa1.59576287
44MP0002736_abnormal_nociception_after1.53645850
45MP0001849_ear_inflammation1.53586738
46MP0009672_abnormal_birth_weight1.53399056
47MP0010094_abnormal_chromosome_stability1.50159435
48MP0003283_abnormal_digestive_organ1.49862849
49MP0005266_abnormal_metabolism1.46467512
50MP0001485_abnormal_pinna_reflex1.44490875
51MP0005551_abnormal_eye_electrophysiolog1.44224749
52MP0003787_abnormal_imprinting1.40710748
53MP0003119_abnormal_digestive_system1.40319485
54MP0002837_dystrophic_cardiac_calcinosis1.40037112
55* MP0002085_abnormal_embryonic_tissue1.38339606
56* MP0002086_abnormal_extraembryonic_tissu1.36070402
57MP0008961_abnormal_basal_metabolism1.35449167
58MP0002092_abnormal_eye_morphology1.34646472
59MP0003183_abnormal_peptide_metabolism1.32894601
60MP0000762_abnormal_tongue_morphology1.32503133
61MP0008789_abnormal_olfactory_epithelium1.29661326
62MP0010030_abnormal_orbit_morphology1.28062728
63MP0008872_abnormal_physiological_respon1.26639362
64MP0004197_abnormal_fetal_growth/weight/1.24562092
65* MP0002084_abnormal_developmental_patter1.23114862
66MP0001529_abnormal_vocalization1.22680271
67MP0001730_embryonic_growth_arrest1.22188345
68MP0001968_abnormal_touch/_nociception1.18739133
69MP0003315_abnormal_perineum_morphology1.17321716
70MP0000049_abnormal_middle_ear1.16932510
71MP0002932_abnormal_joint_morphology1.15397716
72MP0009697_abnormal_copulation1.13530882
73MP0005253_abnormal_eye_physiology1.11686313
74MP0003136_yellow_coat_color1.10741746
75MP0004381_abnormal_hair_follicle1.07742232
76MP0000631_abnormal_neuroendocrine_gland1.07548739
77MP0002233_abnormal_nose_morphology1.07402911
78MP0001697_abnormal_embryo_size1.06786042
79MP0000432_abnormal_head_morphology1.06763405
80MP0006082_CNS_inflammation1.06110306
81MP0002210_abnormal_sex_determination1.05974327
82MP0003693_abnormal_embryo_hatching1.05145045
83MP0001929_abnormal_gametogenesis1.04792935
84MP0003806_abnormal_nucleotide_metabolis1.02715707
85MP0002114_abnormal_axial_skeleton1.02289133
86MP0000428_abnormal_craniofacial_morphol0.99966790
87MP0000579_abnormal_nail_morphology0.99438796
88MP0004043_abnormal_pH_regulation0.98800117
89MP0000490_abnormal_crypts_of0.98121031
90MP0001177_atelectasis0.97609356
91MP0000313_abnormal_cell_death0.97443480
92MP0004147_increased_porphyrin_level0.97352120
93MP0002163_abnormal_gland_morphology0.96840936
94MP0003755_abnormal_palate_morphology0.95176273
95MP0010307_abnormal_tumor_latency0.94602965
96MP0000647_abnormal_sebaceous_gland0.93958536
97MP0001145_abnormal_male_reproductive0.93825548
98MP0002396_abnormal_hematopoietic_system0.93550074
99MP0005248_abnormal_Harderian_gland0.93236996
100MP0008770_decreased_survivor_rate0.93135455
101MP0003935_abnormal_craniofacial_develop0.91791461
102MP0009745_abnormal_behavioral_response0.91625649
103MP0000653_abnormal_sex_gland0.91618993
104MP0002160_abnormal_reproductive_system0.91614699
105* MP0002080_prenatal_lethality0.91180195
106MP0005379_endocrine/exocrine_gland_phen0.91167632
107MP0003878_abnormal_ear_physiology0.90534035
108MP0005377_hearing/vestibular/ear_phenot0.90534035
109MP0004215_abnormal_myocardial_fiber0.89562386
110MP0002249_abnormal_larynx_morphology0.89458235
111MP0005395_other_phenotype0.89172503
112MP0001984_abnormal_olfaction0.89105542
113MP0008007_abnormal_cellular_replicative0.88526236
114MP0009046_muscle_twitch0.88507365
115MP0003186_abnormal_redox_activity0.87806109
116MP0002970_abnormal_white_adipose0.87039238
117MP0005391_vision/eye_phenotype0.86364837
118MP0002090_abnormal_vision0.84673064
119MP0003698_abnormal_male_reproductive0.82377416
120MP0009703_decreased_birth_body0.82286913
121MP0000750_abnormal_muscle_regeneration0.82261296
122MP0003137_abnormal_impulse_conducting0.79190386
123MP0008875_abnormal_xenobiotic_pharmacok0.79121010
124MP0002751_abnormal_autonomic_nervous0.78862074
125MP0005389_reproductive_system_phenotype0.78322764
126MP0002925_abnormal_cardiovascular_devel0.78086903
127MP0002697_abnormal_eye_size0.77601784
128MP0005645_abnormal_hypothalamus_physiol0.76909589
129MP0001286_abnormal_eye_development0.75537153
130MP0002272_abnormal_nervous_system0.75039929
131MP0006276_abnormal_autonomic_nervous0.74507571
132* MP0008932_abnormal_embryonic_tissue0.74281027
133MP0001348_abnormal_lacrimal_gland0.73747273
134MP0001486_abnormal_startle_reflex0.73636388
135MP0005023_abnormal_wound_healing0.73632796
136MP0003786_premature_aging0.72814167
137MP0001324_abnormal_eye_pigmentation0.72542148
138MP0001119_abnormal_female_reproductive0.72061462
139MP0002269_muscular_atrophy0.72008737
140MP0005508_abnormal_skeleton_morphology0.70991103
141MP0005084_abnormal_gallbladder_morpholo0.70658267
142MP0006036_abnormal_mitochondrial_physio0.69884112
143MP0000372_irregular_coat_pigmentation0.69486490
144MP0005174_abnormal_tail_pigmentation0.68774158
145MP0003861_abnormal_nervous_system0.67061228
146MP0003937_abnormal_limbs/digits/tail_de0.66654151
147MP0002116_abnormal_craniofacial_bone0.66564460
148MP0000358_abnormal_cell_content/0.65429753
149MP0005384_cellular_phenotype0.63838129
150MP0002111_abnormal_tail_morphology0.61536724
151MP0008058_abnormal_DNA_repair0.61476387
152MP0002081_perinatal_lethality0.60456124
153MP0002098_abnormal_vibrissa_morphology0.58381629
154MP0002796_impaired_skin_barrier0.52932299
155MP0000383_abnormal_hair_follicle0.52704306
156MP0003448_altered_tumor_morphology0.52647843

Predicted human phenotypes

RankGene SetZ-score
1Hypochromic microcytic anemia (HP:0004840)6.97355859
2Bilateral microphthalmos (HP:0007633)6.94648197
3Hepatoblastoma (HP:0002884)5.80691028
4Ependymoma (HP:0002888)4.94628617
5Multiple enchondromatosis (HP:0005701)4.89079328
6Abnormality of the lower motor neuron (HP:0002366)4.68976218
7Colon cancer (HP:0003003)4.48888988
8Rib fusion (HP:0000902)4.45167334
9Chromosomal breakage induced by crosslinking agents (HP:0003221)4.12849302
10Neoplasm of striated muscle (HP:0009728)4.08815092
11Rhabdomyosarcoma (HP:0002859)4.08336600
12Nephroblastoma (Wilms tumor) (HP:0002667)4.08276642
13Embryonal renal neoplasm (HP:0011794)3.78193344
14Chromsome breakage (HP:0040012)3.54994083
15Testicular atrophy (HP:0000029)3.51278611
16Astrocytoma (HP:0009592)3.47761274
17Abnormality of the astrocytes (HP:0100707)3.47761274
18Fused cervical vertebrae (HP:0002949)3.44298116
19Birth length less than 3rd percentile (HP:0003561)3.32688197
20Abnormality of the salivary glands (HP:0010286)3.32291425
21Hypoplasia of the fovea (HP:0007750)3.23878173
22Aplasia/Hypoplasia of the fovea (HP:0008060)3.23878173
23Amyotrophic lateral sclerosis (HP:0007354)3.15047097
24Aplasia/hypoplasia of the humerus (HP:0006507)3.08251724
25Supernumerary spleens (HP:0009799)3.03713150
26Shawl scrotum (HP:0000049)3.01167214
27Short humerus (HP:0005792)2.98314724
28Abnormal lung lobation (HP:0002101)2.91499260
29Rectal fistula (HP:0100590)2.90781897
30Rectovaginal fistula (HP:0000143)2.90781897
31Horizontal nystagmus (HP:0000666)2.89969969
32Hyperinsulinemic hypoglycemia (HP:0000825)2.86885549
33Trismus (HP:0000211)2.85749655
34Ragged-red muscle fibers (HP:0003200)2.84405360
35Hyperglycinuria (HP:0003108)2.81606357
36Hyperglycinemia (HP:0002154)2.78186896
37Hypochromic anemia (HP:0001931)2.77534743
38Pancreatic cysts (HP:0001737)2.75982654
39Meckel diverticulum (HP:0002245)2.75499372
40Impulsivity (HP:0100710)2.73275620
41Septo-optic dysplasia (HP:0100842)2.70218912
42Large earlobe (HP:0009748)2.69844498
43Glioma (HP:0009733)2.68054776
44Abnormality of chromosome stability (HP:0003220)2.62575724
45Abnormality of glycine metabolism (HP:0010895)2.62068898
46Abnormality of serine family amino acid metabolism (HP:0010894)2.62068898
47Partial duplication of thumb phalanx (HP:0009944)2.61655157
48Abnormality of the ileum (HP:0001549)2.57983026
49Intestinal fistula (HP:0100819)2.56915342
50Abnormal cartilage morphology (HP:0002763)2.56231713
51Anomalous pulmonary venous return (HP:0010772)2.55228655
52Pancreatic fibrosis (HP:0100732)2.55062289
53Abnormality of serum amino acid levels (HP:0003112)2.54229500
54Abolished electroretinogram (ERG) (HP:0000550)2.51565473
55Vaginal fistula (HP:0004320)2.45534422
56Medulloblastoma (HP:0002885)2.44573414
57Methylmalonic acidemia (HP:0002912)2.43967781
58Aplasia/Hypoplasia of the uvula (HP:0010293)2.43707969
59Sensory axonal neuropathy (HP:0003390)2.42651389
60Hypoplasia of the pons (HP:0012110)2.42074945
61Abnormality of the fovea (HP:0000493)2.41264005
62Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.40487995
63Abnormality of chromosome segregation (HP:0002916)2.38841255
64Abnormality of the pons (HP:0007361)2.36737193
65Progressive inability to walk (HP:0002505)2.33557557
66Progressive muscle weakness (HP:0003323)2.32867932
67Preauricular skin tag (HP:0000384)2.32033834
68Aplasia/Hypoplasia of the sternum (HP:0006714)2.31944450
69Neoplasm of the adrenal cortex (HP:0100641)2.31073118
70Malignant neoplasm of the central nervous system (HP:0100836)2.29793073
71Abnormality of alanine metabolism (HP:0010916)2.28396300
72Hyperalaninemia (HP:0003348)2.28396300
73Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.28396300
74Progressive external ophthalmoplegia (HP:0000590)2.27610044
75True hermaphroditism (HP:0010459)2.27389930
76Reduced antithrombin III activity (HP:0001976)2.25149192
77Acute necrotizing encephalopathy (HP:0006965)2.24716139
78Partial duplication of the phalanx of hand (HP:0009999)2.24148314
79Methylmalonic aciduria (HP:0012120)2.23881135
80Abnormality of homocysteine metabolism (HP:0010919)2.22559181
81Homocystinuria (HP:0002156)2.22559181
82Abnormality of midbrain morphology (HP:0002418)2.22474122
83Molar tooth sign on MRI (HP:0002419)2.22474122
84Tetraplegia (HP:0002445)2.21476966
85Abnormality of the musculature of the hand (HP:0001421)2.20192984
86Nasolacrimal duct obstruction (HP:0000579)2.20030069
87Acute encephalopathy (HP:0006846)2.18773104
88Bifid tongue (HP:0010297)2.18030213
89Ectopic kidney (HP:0000086)2.18016226
90Increased hepatocellular lipid droplets (HP:0006565)2.14977473
91Hyperventilation (HP:0002883)2.14279079
92Inability to walk (HP:0002540)2.13852691
93Preauricular pit (HP:0004467)2.13764755
94Periauricular skin pits (HP:0100277)2.13764755
95Premature ovarian failure (HP:0008209)2.13377596
96Abnormality of the pulmonary veins (HP:0011718)2.12920022
97Upper motor neuron abnormality (HP:0002127)2.12162554
98Stenosis of the external auditory canal (HP:0000402)2.11617078
99Supernumerary nipples (HP:0002558)2.11498843
100Difficulty running (HP:0009046)2.11498344
101Small intestinal stenosis (HP:0012848)2.11070907
102Duodenal stenosis (HP:0100867)2.11070907
103Aplasia/Hypoplasia of the macula (HP:0008059)2.09958488
104Neoplasm of the adrenal gland (HP:0100631)2.08692456
105Carpal bone hypoplasia (HP:0001498)2.08662480
106Congenital stationary night blindness (HP:0007642)2.08583298
107Neoplasm of the oral cavity (HP:0100649)2.08231642
108Abnormality of aspartate family amino acid metabolism (HP:0010899)2.08152499
109Lipid accumulation in hepatocytes (HP:0006561)2.07968972
110Generalized hypotonia (HP:0001290)2.07385778
111Pseudobulbar signs (HP:0002200)2.06571621
112Embryonal neoplasm (HP:0002898)2.06090921
113Sloping forehead (HP:0000340)2.05200425
114Nephronophthisis (HP:0000090)2.04781818
115Absent thumb (HP:0009777)2.04683464
116Glossoptosis (HP:0000162)2.04472472
117Microvesicular hepatic steatosis (HP:0001414)2.03450364
118Supernumerary ribs (HP:0005815)2.03265010
119Skin tags (HP:0010609)2.02343934
120Atrophy/Degeneration involving motor neurons (HP:0007373)2.01811965
121Increased CSF lactate (HP:0002490)1.99780984
122Increased connective tissue (HP:0009025)1.99310395
123Abnormality of the duodenum (HP:0002246)1.98863747
124Vertebral fusion (HP:0002948)1.97926618
125Neoplasm of the heart (HP:0100544)1.97188489
1263-Methylglutaconic aciduria (HP:0003535)1.96312449
127Resting tremor (HP:0002322)1.94119510
128Horseshoe kidney (HP:0000085)1.93248721
129Absent radius (HP:0003974)1.93126022
130Tongue fasciculations (HP:0001308)1.91730052
131Pendular nystagmus (HP:0012043)1.91380897
132Patellar aplasia (HP:0006443)1.91333386
133Neuroectodermal neoplasm (HP:0030061)1.89688690
134Neuroepithelial neoplasm (HP:0030063)1.89688690
135Nervous tissue neoplasm (HP:0030060)1.89688690
136Optic nerve hypoplasia (HP:0000609)1.88600753
137Abnormality of the labia minora (HP:0012880)1.88575462
138Supernumerary bones of the axial skeleton (HP:0009144)1.88481279
139Aplasia involving forearm bones (HP:0009822)1.88430396
140Absent forearm bone (HP:0003953)1.88430396
141Pancreatic islet-cell hyperplasia (HP:0004510)1.87733807
142Abnormality of abdominal situs (HP:0011620)1.87363826
143Abdominal situs inversus (HP:0003363)1.87363826
144Amblyopia (HP:0000646)1.87276635
145Aplasia/Hypoplasia affecting the retina (HP:0008061)1.86813823
146Triphalangeal thumb (HP:0001199)1.86552949
147Biliary tract neoplasm (HP:0100574)1.85218303
148Mitochondrial inheritance (HP:0001427)1.84968592
149Progressive macrocephaly (HP:0004481)1.84537447
150Abnormal biliary tract physiology (HP:0012439)1.84430130
151Bile duct proliferation (HP:0001408)1.84430130
152Villous atrophy (HP:0011473)1.84029150
153Abnormality of small intestinal villus morphology (HP:0011472)1.84029150
154Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.83724942
155Neoplasm of the colon (HP:0100273)1.83315198
156Abnormality of the preputium (HP:0100587)1.82776279
157Combined immunodeficiency (HP:0005387)1.82650680
158Abnormality of methionine metabolism (HP:0010901)1.80965936
159Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.80500802
160Primitive neuroectodermal tumor (HP:0030065)1.80500802
161Aplasia/Hypoplasia of the patella (HP:0006498)1.79982896
162Anencephaly (HP:0002323)1.79664684
163Clubbing of toes (HP:0100760)1.78102556
164Abnormal mitochondria in muscle tissue (HP:0008316)1.77527962
165Dandy-Walker malformation (HP:0001305)1.77173322
166Chronic bronchitis (HP:0004469)1.76624687
167Intestinal atresia (HP:0011100)1.76563892
168Absent septum pellucidum (HP:0001331)1.75555431
169Abnormality of the carotid arteries (HP:0005344)1.72758955
170Reticulocytopenia (HP:0001896)1.72705459
171Abnormality of the clitoris (HP:0000056)1.72458413
172Aplasia/Hypoplasia of the hallux (HP:0008362)1.72027923
173Sclerocornea (HP:0000647)1.71963802
174Medial flaring of the eyebrow (HP:0010747)1.70317933

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK129.01667492
2GRK54.63273611
3ERN14.27652335
4ZAK3.72595540
5MKNK23.33642501
6TTK3.23833677
7GRK63.23084170
8TSSK63.12828537
9CSF1R2.73470300
10TYRO32.68233833
11GRK72.60208264
12MKNK12.55141013
13MAPK72.54537884
14WNK32.54058134
15TGFBR22.51587191
16FRK2.49031119
17NUAK12.47689714
18ACVR1B2.45724972
19PLK32.38538960
20TNIK2.38119003
21ADRBK22.36871171
22STK102.36111958
23GRK12.33663543
24MATK2.31058900
25BMPR1B2.30794797
26VRK22.29798480
27PBK2.26098204
28EPHA22.09398332
29MOS2.08267084
30PLK42.03668217
31TAF12.02195580
32WNK11.99024522
33BRSK21.87566280
34AKT31.84932933
35CDK71.78558066
36TRIM281.74116653
37VRK11.68826717
38NTRK11.59566222
39CHEK21.55330836
40OXSR11.42418157
41PAK41.41602084
42CDK191.39648734
43PLK11.38652960
44MAP4K21.33533921
45EIF2AK31.26265423
46STK161.25311355
47PRKG21.25096412
48WEE11.21791797
49TLK11.21359773
50STK38L1.20596933
51BUB11.20081041
52CASK1.16024684
53MARK21.15929532
54WNK41.14852733
55MAP2K41.14036028
56HIPK21.13352094
57NME11.13123956
58PNCK1.12551773
59CAMK41.10943271
60CSNK1G11.08110971
61PASK1.05034113
62NLK1.04118008
63CDC70.99888645
64INSRR0.99795160
65PINK10.98076995
66STK30.97649512
67CHEK10.96846545
68TGFBR10.96459433
69ADRBK10.89985772
70FGFR30.84837904
71CSNK1G20.83637990
72RPS6KB20.82936371
73ALK0.82514650
74TIE10.81591311
75FGFR20.79320786
76EIF2AK20.77013111
77MAP3K40.75187169
78LATS20.73377980
79AKT20.71257838
80ERBB40.70950370
81PRKCG0.69582647
82CSK0.67850000
83PLK20.67369168
84NEK10.67122309
85CSNK1G30.66574717
86AURKA0.65847691
87NEK20.65125467
88STK390.64802052
89CDK20.62003961
90BRSK10.61968552
91MTOR0.61875120
92MAP3K90.59174392
93MAP2K60.58762326
94PRKCI0.57570614
95MAPK120.56081347
96MAP3K100.54705185
97PRPF4B0.54536686
98FGFR10.53403172
99TESK20.52636980
100CSNK1A1L0.52464943
101STK240.51283231
102DYRK20.50449225
103BCR0.49991352
104PAK10.49427067
105CSNK1E0.48708174
106ATM0.48556274
107PRKCE0.48338843
108AURKB0.46008477
109SRPK10.45857817
110CDK40.44709703
111TEC0.44528010
112BCKDK0.42196728
113CSNK2A10.40840309
114PRKDC0.40173143
115TXK0.38873684
116FLT30.37622093
117MAPK100.37452958
118PTK20.37312127
119DAPK20.36997241
120CDK30.36727828
121RPS6KA50.36486593
122CDK10.36388096
123MAPKAPK30.36197114
124CSNK1A10.34261653
125MAP3K70.33974027
126PHKG20.33118874
127PHKG10.33118874
128PIM10.32412261
129CSNK2A20.31183692
130CAMK1D0.29121746
131MET0.28812087
132CAMK1G0.28690907
133ERBB20.28630400
134MAPK130.27563739
135EIF2AK10.27545786
136GSK3B0.27152474
137MAPK10.26228933
138CDK150.26087737
139PDK20.25747197
140BRD40.25629002
141MAPK140.24871928
142IGF1R0.24542617
143CDK11A0.24459062
144INSR0.23351476
145PRKCD0.23312913
146ICK0.22952002
147CDK180.21800336
148DYRK30.21589085
149TAOK20.21420624
150PDK30.21195850
151PDK40.21195850
152DYRK1A0.20989693
153MAP3K80.20615212
154ATR0.19944566
155IKBKB0.18185940
156PAK30.18001625
157DDR20.17564115
158BMX0.17047220
159CDK140.16454881
160PRKACB0.16418144
161STK40.15341182
162CSNK1D0.14875455
163MAPK40.14426628
164PRKACG0.14362888
165GSK3A0.13574406
166STK380.12249247
167PRKD20.12103355
168MST40.11013861
169PAK60.10857852

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.88083213
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006035.82069185
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.67070104
4Fructose and mannose metabolism_Homo sapiens_hsa000513.76206289
5Arachidonic acid metabolism_Homo sapiens_hsa005902.57950500
6RNA transport_Homo sapiens_hsa030132.42494334
7Galactose metabolism_Homo sapiens_hsa000522.42405139
8Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.22330131
9Mismatch repair_Homo sapiens_hsa034302.20793638
10DNA replication_Homo sapiens_hsa030302.19838451
11Linoleic acid metabolism_Homo sapiens_hsa005912.14063463
12Fanconi anemia pathway_Homo sapiens_hsa034602.07426558
13Protein export_Homo sapiens_hsa030601.98216730
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.97723090
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.91734600
16Ribosome_Homo sapiens_hsa030101.91508561
17One carbon pool by folate_Homo sapiens_hsa006701.86283561
18Oxidative phosphorylation_Homo sapiens_hsa001901.76400597
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.69346834
20Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.68773828
21Propanoate metabolism_Homo sapiens_hsa006401.68171121
22mRNA surveillance pathway_Homo sapiens_hsa030151.66463373
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.64634988
24Cell cycle_Homo sapiens_hsa041101.61859384
25Homologous recombination_Homo sapiens_hsa034401.59994509
26Pentose and glucuronate interconversions_Homo sapiens_hsa000401.57903571
27Parkinsons disease_Homo sapiens_hsa050121.56316907
28Spliceosome_Homo sapiens_hsa030401.56031952
29Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.53652721
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.50074083
31Phototransduction_Homo sapiens_hsa047441.48355681
32Steroid biosynthesis_Homo sapiens_hsa001001.48329322
33Thyroid cancer_Homo sapiens_hsa052161.46353052
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.38103227
35mTOR signaling pathway_Homo sapiens_hsa041501.36864813
36RNA polymerase_Homo sapiens_hsa030201.31957435
37RNA degradation_Homo sapiens_hsa030181.31093639
38Huntingtons disease_Homo sapiens_hsa050161.25839915
39Purine metabolism_Homo sapiens_hsa002301.24123453
40Butanoate metabolism_Homo sapiens_hsa006501.14123572
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.13401409
42* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.12617773
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.12350996
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.07089942
45Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.05668635
46Caffeine metabolism_Homo sapiens_hsa002321.04849770
47Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.04481579
48Nitrogen metabolism_Homo sapiens_hsa009101.03854015
49Folate biosynthesis_Homo sapiens_hsa007901.02254006
50Nicotine addiction_Homo sapiens_hsa050331.01586817
51p53 signaling pathway_Homo sapiens_hsa041151.00576186
52Base excision repair_Homo sapiens_hsa034100.99755669
53Pyruvate metabolism_Homo sapiens_hsa006200.98653331
54Ether lipid metabolism_Homo sapiens_hsa005650.95411285
55Maturity onset diabetes of the young_Homo sapiens_hsa049500.93113219
56Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.92125654
57Vitamin digestion and absorption_Homo sapiens_hsa049770.91552903
58Other glycan degradation_Homo sapiens_hsa005110.89562340
59Chemical carcinogenesis_Homo sapiens_hsa052040.87464740
60Basal cell carcinoma_Homo sapiens_hsa052170.86717169
61Nucleotide excision repair_Homo sapiens_hsa034200.86101467
62Fatty acid elongation_Homo sapiens_hsa000620.85550531
63Hedgehog signaling pathway_Homo sapiens_hsa043400.85409325
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.84801096
65Basal transcription factors_Homo sapiens_hsa030220.83261067
66Alzheimers disease_Homo sapiens_hsa050100.82741440
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.82719207
68Pentose phosphate pathway_Homo sapiens_hsa000300.82396950
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.80133021
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.80111442
71MicroRNAs in cancer_Homo sapiens_hsa052060.79485299
72beta-Alanine metabolism_Homo sapiens_hsa004100.78693394
73Peroxisome_Homo sapiens_hsa041460.72513216
74Biosynthesis of amino acids_Homo sapiens_hsa012300.72260266
75Regulation of actin cytoskeleton_Homo sapiens_hsa048100.72000987
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.69535303
77Pyrimidine metabolism_Homo sapiens_hsa002400.68881428
78Pathways in cancer_Homo sapiens_hsa052000.68222223
79Inositol phosphate metabolism_Homo sapiens_hsa005620.67944139
80Retinol metabolism_Homo sapiens_hsa008300.66458186
81Ovarian steroidogenesis_Homo sapiens_hsa049130.65632645
82Taste transduction_Homo sapiens_hsa047420.64606288
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.64157722
84Cardiac muscle contraction_Homo sapiens_hsa042600.63546465
85Central carbon metabolism in cancer_Homo sapiens_hsa052300.62286374
86Hippo signaling pathway_Homo sapiens_hsa043900.61318682
87Non-homologous end-joining_Homo sapiens_hsa034500.60420701
88Glycosaminoglycan degradation_Homo sapiens_hsa005310.60263775
89Choline metabolism in cancer_Homo sapiens_hsa052310.59090565
90Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.58372274
91Carbon metabolism_Homo sapiens_hsa012000.58356988
92RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.57082655
93Primary bile acid biosynthesis_Homo sapiens_hsa001200.56927024
94Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.56726538
95Cyanoamino acid metabolism_Homo sapiens_hsa004600.55525254
962-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.54771580
97Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.54147708
98Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53453365
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.53358839
100Arginine and proline metabolism_Homo sapiens_hsa003300.53209806
101Fatty acid degradation_Homo sapiens_hsa000710.52931797
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52123826
103Fat digestion and absorption_Homo sapiens_hsa049750.51979075
104Rap1 signaling pathway_Homo sapiens_hsa040150.49867773
105Acute myeloid leukemia_Homo sapiens_hsa052210.48647417
106Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47700785
107Cysteine and methionine metabolism_Homo sapiens_hsa002700.46681991
108Wnt signaling pathway_Homo sapiens_hsa043100.46450260
109TGF-beta signaling pathway_Homo sapiens_hsa043500.46159516
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45096712
111Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.44643950
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43370270
113Notch signaling pathway_Homo sapiens_hsa043300.42581249
114Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.41489844
115Bladder cancer_Homo sapiens_hsa052190.40464630
116Olfactory transduction_Homo sapiens_hsa047400.40003010
117African trypanosomiasis_Homo sapiens_hsa051430.39900301
118Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.39380880
119Fatty acid metabolism_Homo sapiens_hsa012120.38820879
120Lysine degradation_Homo sapiens_hsa003100.36839980
121Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36808024
122Herpes simplex infection_Homo sapiens_hsa051680.36666008
123Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.36579207
124Regulation of autophagy_Homo sapiens_hsa041400.35909627
125Tight junction_Homo sapiens_hsa045300.33723216
126Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.33065546
127Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.31438111
128Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.29856698
129Sulfur relay system_Homo sapiens_hsa041220.29702833
130Tryptophan metabolism_Homo sapiens_hsa003800.28761407
131Metabolic pathways_Homo sapiens_hsa011000.27145788
132Oocyte meiosis_Homo sapiens_hsa041140.26900392
133AMPK signaling pathway_Homo sapiens_hsa041520.26882295
134Selenocompound metabolism_Homo sapiens_hsa004500.25808032
135Non-small cell lung cancer_Homo sapiens_hsa052230.23190852
136Glutathione metabolism_Homo sapiens_hsa004800.23022855
137Viral carcinogenesis_Homo sapiens_hsa052030.22979827
138Phosphatidylinositol signaling system_Homo sapiens_hsa040700.21695021
139Proteasome_Homo sapiens_hsa030500.20232909
140PI3K-Akt signaling pathway_Homo sapiens_hsa041510.19122799
141Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.18976286
142HTLV-I infection_Homo sapiens_hsa051660.18564197
143Adherens junction_Homo sapiens_hsa045200.18024650
144Ras signaling pathway_Homo sapiens_hsa040140.17252783
145Apoptosis_Homo sapiens_hsa042100.16896191
146Colorectal cancer_Homo sapiens_hsa052100.15310939
147Serotonergic synapse_Homo sapiens_hsa047260.14830847

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