ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	peptidyl-histidine modification (GO:0018202)	6.30526354
2	rRNA methylation (GO:0031167)	5.58743006
3	rRNA modification (GO:0000154)	5.54290558
4	maturation of 5.8S rRNA (GO:0000460)	5.22164240
5	water-soluble vitamin biosynthetic process (GO:0042364)	4.69847631
6	negative regulation of acute inflammatory response (GO:0002674)	4.69648736
7	positive regulation of glycoprotein biosynthetic process (GO:0010560)	4.67026858
8	respiratory chain complex IV assembly (GO:0008535)	4.36613131
9	protein K6-linked ubiquitination (GO:0085020)	4.32120512
10	snRNA transcription (GO:0009301)	4.27876816
11	positive regulation of protein autophosphorylation (GO:0031954)	4.13123811
12	proteasome assembly (GO:0043248)	4.01854219
13	positive regulation of glycoprotein metabolic process (GO:1903020)	3.85022435
14	keratinocyte development (GO:0003334)	3.83834666
15	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.83688663
16	termination of RNA polymerase III transcription (GO:0006386)	3.83688663
17	very-low-density lipoprotein particle assembly (GO:0034379)	3.75671270
18	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.67464876
19	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.61540327
20	positive regulation of chromosome segregation (GO:0051984)	3.57398305
21	positive regulation of glycolytic process (GO:0045821)	3.54730639
22	positive regulation of respiratory burst (GO:0060267)	3.53409438
23	positive regulation of protein sumoylation (GO:0033235)	3.44325038
24	positive regulation of mitotic sister chromatid separation (GO:1901970)	3.41319076
25	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	3.41319076
26	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	3.41319076
27	DNA double-strand break processing (GO:0000729)	3.41236073
28	cytochrome complex assembly (GO:0017004)	3.40533722
29	cullin deneddylation (GO:0010388)	3.37736294
30	nucleotide-excision repair, DNA gap filling (GO:0006297)	3.37179915
31	DNA replication checkpoint (GO:0000076)	3.33273719
32	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class	3.29951571
33	protein deneddylation (GO:0000338)	3.29486249
34	viral mRNA export from host cell nucleus (GO:0046784)	3.25344227
35	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.12834159
36	chromatin remodeling at centromere (GO:0031055)	3.11575817
37	uterus development (GO:0060065)	3.09974509
38	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	3.06337039
39	tryptophan catabolic process (GO:0006569)	3.04455093
40	indole-containing compound catabolic process (GO:0042436)	3.04455093
41	indolalkylamine catabolic process (GO:0046218)	3.04455093
42	dendritic spine morphogenesis (GO:0060997)	3.04042324
43	nuclear pore organization (GO:0006999)	3.02848372
44	CENP-A containing nucleosome assembly (GO:0034080)	3.00036282
45	postreplication repair (GO:0006301)	2.98717211
46	telomere maintenance via telomerase (GO:0007004)	2.98440916
47	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.96297028
48	replication fork processing (GO:0031297)	2.94279370
49	double-strand break repair via homologous recombination (GO:0000724)	2.93567389
50	rRNA processing (GO:0006364)	2.93037230
51	recombinational repair (GO:0000725)	2.88502598
52	kinetochore organization (GO:0051383)	2.83997091
53	rRNA metabolic process (GO:0016072)	2.83700391
54	translesion synthesis (GO:0019985)	2.82537312
55	transcription from RNA polymerase III promoter (GO:0006383)	2.77939933
56	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.77425995
57	ATP synthesis coupled proton transport (GO:0015986)	2.77425995
58	nuclear pore complex assembly (GO:0051292)	2.76784019
59	prenylation (GO:0097354)	2.70713476
60	protein prenylation (GO:0018342)	2.70713476
61	telomere maintenance via semi-conservative replication (GO:0032201)	2.68408577
62	negative regulation of neurological system process (GO:0031645)	2.67574204
63	negative regulation of gluconeogenesis (GO:0045721)	2.65518281
64	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.64787815
65	inositol phosphate dephosphorylation (GO:0046855)	2.64787815
66	regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	2.63167427
67	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.62182176
68	negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)	2.61813467
69	negative regulation of glycogen metabolic process (GO:0070874)	2.60451167
70	chaperone-mediated protein transport (GO:0072321)	2.59425854
71	DNA strand elongation (GO:0022616)	2.59398622
72	histone exchange (GO:0043486)	2.57962153
73	synaptic transmission, dopaminergic (GO:0001963)	2.56875410
74	fatty acid homeostasis (GO:0055089)	2.56873004
75	DNA replication-independent nucleosome assembly (GO:0006336)	2.54728175
76	DNA replication-independent nucleosome organization (GO:0034724)	2.54728175
77	righting reflex (GO:0060013)	2.54650918
78	telomere maintenance via telomere lengthening (GO:0010833)	2.53960393
79	negative regulation of inflammatory response to antigenic stimulus (GO:0002862)	2.53863955
80	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.53859786
81	DNA strand elongation involved in DNA replication (GO:0006271)	2.53342549
82	mitotic sister chromatid cohesion (GO:0007064)	2.53058591
83	regulation of acrosome reaction (GO:0060046)	2.51928318
84	pseudouridine synthesis (GO:0001522)	2.51810483
85	centriole replication (GO:0007099)	2.51667407
86	regulation of centriole replication (GO:0046599)	2.51401801
87	amino acid activation (GO:0043038)	2.51099772
88	tRNA aminoacylation (GO:0043039)	2.51099772
89	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.50362330
90	DNA catabolic process, exonucleolytic (GO:0000738)	2.48102557
91	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.47334747
92	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.46936047
93	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.46936047
94	RNA-dependent DNA replication (GO:0006278)	2.45782752
95	tRNA aminoacylation for protein translation (GO:0006418)	2.45574030
96	dorsal/ventral axis specification (GO:0009950)	2.45474897
97	prostate gland growth (GO:0060736)	2.45418638
98	ncRNA processing (GO:0034470)	2.45139601
99	tRNA processing (GO:0008033)	2.44939117
100	regulation of protein autophosphorylation (GO:0031952)	2.43788007

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	5.87232837
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.64021902
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.23844623
4	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	3.59161844
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.44748955
6	E2F4_17652178_ChIP-ChIP_JURKAT_Human	3.33725986
7	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.27720564
8	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.26668799
9	ELK1_19687146_ChIP-ChIP_HELA_Human	2.80491658
10	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.69970135
11	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.61678367
12	IGF1R_20145208_ChIP-Seq_DFB_Human	2.57875117
13	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.51249593
14	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.50901518
15	VDR_22108803_ChIP-Seq_LS180_Human	2.49330729
16	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.38069171
17	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.34354321
18	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.32955507
19	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.29771687
20	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.21879937
21	MYC_18940864_ChIP-ChIP_HL60_Human	2.18898674
22	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.17339620
23	VDR_23849224_ChIP-Seq_CD4+_Human	2.15383967
24	AR_21909140_ChIP-Seq_LNCAP_Human	2.13503979
25	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.12866615
26	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.10163859
27	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	2.02721660
28	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.92516002
29	EWS_26573619_Chip-Seq_HEK293_Human	1.89694260
30	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.86148101
31	ZNF274_21170338_ChIP-Seq_K562_Hela	1.77759327
32	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.77369682
33	TTF2_22483619_ChIP-Seq_HELA_Human	1.75201668
34	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.73856237
35	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.68402619
36	DCP1A_22483619_ChIP-Seq_HELA_Human	1.67252970
37	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.63763824
38	FOXP3_21729870_ChIP-Seq_TREG_Human	1.61635644
39	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.58436976
40	ER_23166858_ChIP-Seq_MCF-7_Human	1.57982487
41	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.57534579
42	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.44586839
43	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.42964295
44	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.38392059
45	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.31063867
46	FUS_26573619_Chip-Seq_HEK293_Human	1.29324490
47	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.28790346
48	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.27057051
49	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.27027801
50	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.24798340
51	XRN2_22483619_ChIP-Seq_HELA_Human	1.21040654
52	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.19822411
53	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.18465970
54	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.16999555
55	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.16422042
56	GABP_19822575_ChIP-Seq_HepG2_Human	1.15774921
57	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.15261926
58	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.15172179
59	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.13230724
60	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.09336338
61	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.06432566
62	CBP_20019798_ChIP-Seq_JUKART_Human	1.05195113
63	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.05195113
64	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.03387760
65	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.03062500
66	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.02595058
67	KDM5A_27292631_Chip-Seq_BREAST_Human	1.01224919
68	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.01140547
69	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.99583089
70	P300_19829295_ChIP-Seq_ESCs_Human	0.98823208
71	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.95485030
72	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	0.94605850
73	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.92321268
74	RBPJ_21746931_ChIP-Seq_IB4_Human	0.91795896
75	AR_21572438_ChIP-Seq_LNCaP_Human	0.90964263
76	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.90373531
77	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.88735825
78	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.88275667
79	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.87465236
80	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.86648839
81	PHF8_20622853_ChIP-Seq_HELA_Human	0.86237599
82	ELF5_23300383_ChIP-Seq_T47D_Human	0.84500896
83	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.84059756
84	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.83845209
85	SOX9_26525672_Chip-Seq_HEART_Mouse	0.83347691
86	TP53_22573176_ChIP-Seq_HFKS_Human	0.82261985
87	SMAD4_21799915_ChIP-Seq_A2780_Human	0.81881430
88	P53_22387025_ChIP-Seq_ESCs_Mouse	0.80731038
89	ETV1_20927104_ChIP-Seq_GIST48_Human	0.80504671
90	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.80471286
91	TFEB_21752829_ChIP-Seq_HELA_Human	0.79696757
92	NFYA_21822215_ChIP-Seq_K562_Human	0.79637308
93	ESR1_20079471_ChIP-ChIP_T-47D_Human	0.79330838
94	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.79181332
95	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.78466032
96	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.78445407
97	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.77914692
98	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.76212288
99	RBPJ_22232070_ChIP-Seq_NCS_Mouse	0.75580230
100	CDX2_22108803_ChIP-Seq_LS180_Human	0.75402729

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003787_abnormal_imprinting	5.19546919
2	MP0003123_paternal_imprinting	4.78447072
3	MP0005451_abnormal_body_composition	4.41575252
4	MP0002163_abnormal_gland_morphology	3.82063694
5	MP0003195_calcinosis	3.37984579
6	MP0010234_abnormal_vibrissa_follicle	3.20383658
7	MP0010094_abnormal_chromosome_stability	3.13986633
8	MP0005379_endocrine/exocrine_gland_phen	2.86903048
9	MP0000427_abnormal_hair_cycle	2.74136954
10	MP0003890_abnormal_embryonic-extraembry	2.59492864
11	MP0001661_extended_life_span	2.55790731
12	MP0005408_hypopigmentation	2.39072557
13	MP0003121_genomic_imprinting	2.19875362
14	MP0004957_abnormal_blastocyst_morpholog	2.04774081
15	MP0003786_premature_aging	2.04054284
16	MP0003111_abnormal_nucleus_morphology	1.87256432
17	MP0009697_abnormal_copulation	1.87225999
18	MP0003693_abnormal_embryo_hatching	1.82213398
19	MP0000647_abnormal_sebaceous_gland	1.78180312
20	MP0002234_abnormal_pharynx_morphology	1.77065151
21	MP0001986_abnormal_taste_sensitivity	1.74554922
22	MP0010678_abnormal_skin_adnexa	1.73434337
23	MP0003950_abnormal_plasma_membrane	1.72987493
24	MP0008058_abnormal_DNA_repair	1.69051195
25	MP0002160_abnormal_reproductive_system	1.69025973
26	MP0006072_abnormal_retinal_apoptosis	1.68735028
27	MP0010307_abnormal_tumor_latency	1.64833554
28	MP0009780_abnormal_chondrocyte_physiolo	1.61878124
29	MP0008995_early_reproductive_senescence	1.61809756
30	MP0009046_muscle_twitch	1.48435990
31	MP0000639_abnormal_adrenal_gland	1.47702874
32	MP0001727_abnormal_embryo_implantation	1.44069148
33	MP0003077_abnormal_cell_cycle	1.43793815
34	MP0005253_abnormal_eye_physiology	1.40724060
35	MP0008057_abnormal_DNA_replication	1.39870034
36	MP0008877_abnormal_DNA_methylation	1.38809533
37	MP0000516_abnormal_urinary_system	1.36789156
38	MP0005367_renal/urinary_system_phenotyp	1.36789156
39	MP0000579_abnormal_nail_morphology	1.33763946
40	MP0002098_abnormal_vibrissa_morphology	1.31812344
41	MP0002396_abnormal_hematopoietic_system	1.24255865
42	MP0000383_abnormal_hair_follicle	1.23810031
43	MP0002095_abnormal_skin_pigmentation	1.21599833
44	MP0010352_gastrointestinal_tract_polyps	1.18394272
45	MP0002837_dystrophic_cardiac_calcinosis	1.17284047
46	MP0006036_abnormal_mitochondrial_physio	1.16155258
47	MP0008007_abnormal_cellular_replicative	1.13802722
48	MP0000538_abnormal_urinary_bladder	1.12852108
49	MP0003119_abnormal_digestive_system	1.12203238
50	MP0003806_abnormal_nucleotide_metabolis	1.10282162
51	MP0004197_abnormal_fetal_growth/weight/	1.08251508
52	MP0005646_abnormal_pituitary_gland	1.07917430
53	MP0002282_abnormal_trachea_morphology	1.04056767
54	MP0003011_delayed_dark_adaptation	1.02170954
55	MP0005389_reproductive_system_phenotype	1.00519391
56	MP0005220_abnormal_exocrine_pancreas	0.96719327
57	MP0005075_abnormal_melanosome_morpholog	0.96645158
58	MP0004215_abnormal_myocardial_fiber	0.95576783
59	MP0001188_hyperpigmentation	0.91964570
60	MP0002102_abnormal_ear_morphology	0.88723338
61	MP0001944_abnormal_pancreas_morphology	0.87410253
62	MP0003718_maternal_effect	0.87033389
63	MP0005623_abnormal_meninges_morphology	0.85907693
64	MP0001697_abnormal_embryo_size	0.84960295
65	MP0003984_embryonic_growth_retardation	0.81690804
66	MP0001286_abnormal_eye_development	0.81333745
67	MP0002088_abnormal_embryonic_growth/wei	0.81138133
68	MP0001672_abnormal_embryogenesis/_devel	0.79767008
69	MP0005380_embryogenesis_phenotype	0.79767008
70	MP0002938_white_spotting	0.79266242
71	MP0002210_abnormal_sex_determination	0.75658626
72	MP0004145_abnormal_muscle_electrophysio	0.75285042
73	MP0005551_abnormal_eye_electrophysiolog	0.74183870
74	MP0001186_pigmentation_phenotype	0.72137686
75	MP0001270_distended_abdomen	0.70998207
76	MP0001764_abnormal_homeostasis	0.70221662
77	MP0001984_abnormal_olfaction	0.67912315
78	MP0005332_abnormal_amino_acid	0.66801209
79	MP0003936_abnormal_reproductive_system	0.66351731
80	MP0005174_abnormal_tail_pigmentation	0.66102682
81	MP0004270_analgesia	0.65500723
82	MP0003943_abnormal_hepatobiliary_system	0.65468298
83	MP0000613_abnormal_salivary_gland	0.65433208
84	MP0005423_abnormal_somatic_nervous	0.64118286
85	MP0005391_vision/eye_phenotype	0.63894594
86	MP0002970_abnormal_white_adipose	0.63267425
87	MP0001730_embryonic_growth_arrest	0.62848896
88	MP0008932_abnormal_embryonic_tissue	0.62792954
89	MP0002751_abnormal_autonomic_nervous	0.60971161
90	MP0003942_abnormal_urinary_system	0.60919057
91	MP0003315_abnormal_perineum_morphology	0.60649960
92	MP0001929_abnormal_gametogenesis	0.60376866
93	MP0002928_abnormal_bile_duct	0.59762168
94	MP0000631_abnormal_neuroendocrine_gland	0.59163755
95	MP0001145_abnormal_male_reproductive	0.58863619
96	MP0000377_abnormal_hair_follicle	0.57835827
97	MP0002638_abnormal_pupillary_reflex	0.57522929
98	MP0002009_preneoplasia	0.56494746
99	MP0002184_abnormal_innervation	0.56451279
100	MP0001529_abnormal_vocalization	0.55976338

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Neoplasm of the adrenal cortex (HP:0100641)	6.39009350
2	Metaphyseal dysplasia (HP:0100255)	5.63418421
3	Hepatoblastoma (HP:0002884)	3.79429946
4	Adrenal hypoplasia (HP:0000835)	3.56850074
5	Neoplasm of the adrenal gland (HP:0100631)	3.55202644
6	Abnormality of the preputium (HP:0100587)	3.36391078
7	Neonatal hypoglycemia (HP:0001998)	3.33365507
8	Ketoacidosis (HP:0001993)	3.25200283
9	Congenital, generalized hypertrichosis (HP:0004540)	3.21617820
10	Chromsome breakage (HP:0040012)	3.19988183
11	Aplasia/Hypoplasia of the uvula (HP:0010293)	3.10621599
12	Abnormality of chromosome stability (HP:0003220)	3.05280395
13	Pili torti (HP:0003777)	2.93687882
14	Diastasis recti (HP:0001540)	2.93297067
15	Birth length less than 3rd percentile (HP:0003561)	2.79009995
16	Aqueductal stenosis (HP:0002410)	2.78718330
17	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.69716730
18	Hyperinsulinemic hypoglycemia (HP:0000825)	2.64287568
19	Meckel diverticulum (HP:0002245)	2.63544015
20	Abnormal pancreas size (HP:0012094)	2.63469022
21	Type 2 muscle fiber atrophy (HP:0003554)	2.62271487
22	Progressive macrocephaly (HP:0004481)	2.61657431
23	Sparse eyelashes (HP:0000653)	2.61381250
24	Enlarged kidneys (HP:0000105)	2.61069583
25	Hypoglycemic coma (HP:0001325)	2.59801674
26	Hypomagnesemia (HP:0002917)	2.56991947
27	Abnormality of methionine metabolism (HP:0010901)	2.54548822
28	Methylmalonic acidemia (HP:0002912)	2.53544082
29	Homocystinuria (HP:0002156)	2.53466999
30	Abnormality of homocysteine metabolism (HP:0010919)	2.53466999
31	Abnormality of the pancreatic islet cells (HP:0006476)	2.48717061
32	Abnormality of endocrine pancreas physiology (HP:0012093)	2.48717061
33	Cutaneous melanoma (HP:0012056)	2.48630715
34	Abnormality of the ileum (HP:0001549)	2.45683920
35	Sensory axonal neuropathy (HP:0003390)	2.45330393
36	3-Methylglutaconic aciduria (HP:0003535)	2.38802654
37	Enlarged penis (HP:0000040)	2.38474486
38	Hypoplasia of the pons (HP:0012110)	2.35692572
39	Asymmetry of the thorax (HP:0001555)	2.33236040
40	Abnormality of the pons (HP:0007361)	2.32917574
41	Ependymoma (HP:0002888)	2.31908296
42	Molar tooth sign on MRI (HP:0002419)	2.30041945
43	Abnormality of midbrain morphology (HP:0002418)	2.30041945
44	Hypoglycemic seizures (HP:0002173)	2.25554530
45	Muscle fiber atrophy (HP:0100295)	2.24233464
46	Septate vagina (HP:0001153)	2.23419857
47	Embryonal renal neoplasm (HP:0011794)	2.22731134
48	Symptomatic seizures (HP:0011145)	2.22288217
49	Nephroblastoma (Wilms tumor) (HP:0002667)	2.20514536
50	Follicular hyperkeratosis (HP:0007502)	2.17767160
51	Acute necrotizing encephalopathy (HP:0006965)	2.17469650
52	Poor suck (HP:0002033)	2.17021095
53	Hamartoma of the eye (HP:0010568)	2.12510970
54	Increased hepatocellular lipid droplets (HP:0006565)	2.11342380
55	Constricted visual fields (HP:0001133)	2.09366714
56	Lipid accumulation in hepatocytes (HP:0006561)	2.09051814
57	Hypothermia (HP:0002045)	2.07564125
58	Ketosis (HP:0001946)	2.06739015
59	Absent thumb (HP:0009777)	2.05334842
60	Abnormality of the astrocytes (HP:0100707)	2.04957578
61	Astrocytoma (HP:0009592)	2.04957578
62	Acute encephalopathy (HP:0006846)	2.04920587
63	Squamous cell carcinoma (HP:0002860)	2.04480474
64	Prominent metopic ridge (HP:0005487)	2.01883174
65	Nonprogressive disorder (HP:0003680)	2.00437310
66	Malnutrition (HP:0004395)	1.99515546
67	Hepatic necrosis (HP:0002605)	1.98763739
68	Methylmalonic aciduria (HP:0012120)	1.96982878
69	Amniotic constriction ring (HP:0009775)	1.96414062
70	Abnormality of placental membranes (HP:0011409)	1.96414062
71	Woolly hair (HP:0002224)	1.94099077
72	Cystic hygroma (HP:0000476)	1.91664123
73	Hyperglycemia (HP:0003074)	1.90731048
74	Volvulus (HP:0002580)	1.89429110
75	Glioma (HP:0009733)	1.87164085
76	Hyperventilation (HP:0002883)	1.86803121
77	Thyroid carcinoma (HP:0002890)	1.85992503
78	Horseshoe kidney (HP:0000085)	1.85528376
79	Fatigable weakness (HP:0003473)	1.83759704
80	Abnormality of the neuromuscular junction (HP:0003398)	1.83759704
81	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.82080009
82	Sparse lateral eyebrow (HP:0005338)	1.81405129
83	Abnormality of magnesium homeostasis (HP:0004921)	1.80408043
84	Small intestinal stenosis (HP:0012848)	1.79994743
85	Duodenal stenosis (HP:0100867)	1.79994743
86	Abnormality of the carotid arteries (HP:0005344)	1.79849523
87	Renal cortical cysts (HP:0000803)	1.78264519
88	Breast carcinoma (HP:0003002)	1.73737723
89	Abnormality of the duodenum (HP:0002246)	1.73418675
90	Increased serum lactate (HP:0002151)	1.73343664
91	Degeneration of anterior horn cells (HP:0002398)	1.72942296
92	Abnormality of the anterior horn cell (HP:0006802)	1.72942296
93	Mitochondrial inheritance (HP:0001427)	1.70678657
94	Oral leukoplakia (HP:0002745)	1.70661234
95	Dandy-Walker malformation (HP:0001305)	1.70167643
96	Myelodysplasia (HP:0002863)	1.69959743
97	Tongue fasciculations (HP:0001308)	1.69699979
98	Dicarboxylic aciduria (HP:0003215)	1.68660156
99	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.68660156
100	Thyroiditis (HP:0100646)	1.68570816

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	7.65983236
2	MUSK	4.09282962
3	MST4	3.55309911
4	FGFR2	3.51971339
5	STK24	3.29200211
6	EIF2AK1	3.08680559
7	BMPR1B	2.84813502
8	SRPK1	2.78648084
9	ACVR1B	2.66117075
10	STK38L	2.60515168
11	NUAK1	2.44858264
12	MKNK2	2.02848098
13	EIF2AK3	1.85964880
14	TTK	1.79291776
15	GRK1	1.68774705
16	CDC7	1.60161468
17	PRKD3	1.56217332
18	PNCK	1.54826527
19	CSNK1G1	1.53641583
20	PLK3	1.46458533
21	OXSR1	1.43403074
22	WNK3	1.33034220
23	PBK	1.29289358
24	VRK2	1.25540279
25	NME1	1.24294142
26	ERBB3	1.23676392
27	STK39	1.20586921
28	INSRR	1.14289180
29	CHEK2	1.07806956
30	CDK19	1.07195428
31	BUB1	1.04038368
32	PHKG2	1.02714603
33	PHKG1	1.02714603
34	PLK1	1.01544597
35	MKNK1	1.00602296
36	PLK4	0.98179327
37	TNIK	0.97811136
38	PINK1	0.97063319
39	CSNK1G3	0.89496827
40	MST1R	0.88840767
41	TGFBR1	0.88479789
42	CSNK1A1L	0.86397954
43	WNK4	0.86281204
44	CSNK1G2	0.82504188
45	MAP4K2	0.81130593
46	BRD4	0.76522582
47	BRSK2	0.74559589
48	NLK	0.70466197
49	ATR	0.69794554
50	TSSK6	0.69611084
51	CDK8	0.69548834
52	PLK2	0.65645012
53	NME2	0.63868748
54	ZAK	0.62660330
55	RPS6KA4	0.61586361
56	IRAK2	0.61553282
57	SIK3	0.60844960
58	ATM	0.57116859
59	EPHA2	0.55930791
60	STK16	0.54600663
61	CDK4	0.54320055
62	FGFR3	0.54239077
63	MELK	0.53353445
64	AURKB	0.52095805
65	TRIM28	0.47831413
66	PRKAA2	0.46935910
67	EIF2AK2	0.43612647
68	MAP3K4	0.43376568
69	VRK1	0.43170978
70	IRAK3	0.39008205
71	CSNK1E	0.38895181
72	PRKAA1	0.38882144
73	CSNK2A1	0.37899133
74	CDK7	0.36877643
75	STK3	0.36576465
76	BCR	0.36346402
77	PAK3	0.34735244
78	WEE1	0.34384912
79	CSNK2A2	0.33132057
80	NTRK3	0.32680779
81	MAP3K9	0.31901206
82	TLK1	0.31091370
83	PRKCI	0.30732348
84	DAPK1	0.29903464
85	PRKD2	0.29755412
86	ADRBK1	0.28244931
87	PRKCG	0.27895366
88	MAP2K1	0.27663051
89	MAP2K4	0.27569369
90	CSNK1D	0.26770489
91	MAP3K12	0.25876698
92	KSR1	0.25425359
93	MAP3K2	0.25243487
94	TAF1	0.24674583
95	CASK	0.24433274
96	CHEK1	0.23972981
97	MAP3K10	0.22823464
98	CDK1	0.22257623
99	PTK2	0.21869123
100	ROCK1	0.21689491

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Vitamin B6 metabolism_Homo sapiens_hsa00750	4.42932003
2	Maturity onset diabetes of the young_Homo sapiens_hsa04950	3.56270311
3	Homologous recombination_Homo sapiens_hsa03440	3.34891921
4	Fanconi anemia pathway_Homo sapiens_hsa03460	3.12060507
5	Protein export_Homo sapiens_hsa03060	2.97669505
6	Mismatch repair_Homo sapiens_hsa03430	2.90661872
7	Steroid biosynthesis_Homo sapiens_hsa00100	2.74391455
8	Proteasome_Homo sapiens_hsa03050	2.69426587
9	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.64996790
10	DNA replication_Homo sapiens_hsa03030	2.54681746
11	Basal transcription factors_Homo sapiens_hsa03022	2.25997498
12	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.24317524
13	Oxidative phosphorylation_Homo sapiens_hsa00190	2.17161647
14	RNA polymerase_Homo sapiens_hsa03020	2.07744589
15	Butanoate metabolism_Homo sapiens_hsa00650	1.94129101
16	RNA transport_Homo sapiens_hsa03013	1.80203400
17	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.73144845
18	Cell cycle_Homo sapiens_hsa04110	1.71673047
19	Spliceosome_Homo sapiens_hsa03040	1.70536611
20	Fatty acid elongation_Homo sapiens_hsa00062	1.70450829
21	RNA degradation_Homo sapiens_hsa03018	1.67770008
22	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.55954684
23	Non-homologous end-joining_Homo sapiens_hsa03450	1.53892775
24	Nucleotide excision repair_Homo sapiens_hsa03420	1.53499355
25	Ribosome_Homo sapiens_hsa03010	1.53135668
26	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.34123026
27	Parkinsons disease_Homo sapiens_hsa05012	1.29581706
28	Regulation of autophagy_Homo sapiens_hsa04140	1.23053302
29	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.21957084
30	One carbon pool by folate_Homo sapiens_hsa00670	1.21713873
31	Tryptophan metabolism_Homo sapiens_hsa00380	1.19126809
32	Cardiac muscle contraction_Homo sapiens_hsa04260	1.17442342
33	mRNA surveillance pathway_Homo sapiens_hsa03015	1.15719484
34	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.12867319
35	Fatty acid metabolism_Homo sapiens_hsa01212	1.12432427
36	Pyrimidine metabolism_Homo sapiens_hsa00240	1.09139952
37	Sulfur metabolism_Homo sapiens_hsa00920	1.06027254
38	Huntingtons disease_Homo sapiens_hsa05016	1.03947444
39	Selenocompound metabolism_Homo sapiens_hsa00450	1.03315938
40	Alzheimers disease_Homo sapiens_hsa05010	1.02218296
41	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.99687528
42	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.99386507
43	Nicotine addiction_Homo sapiens_hsa05033	0.95674128
44	Collecting duct acid secretion_Homo sapiens_hsa04966	0.94806602
45	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.94664929
46	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.92913224
47	Oocyte meiosis_Homo sapiens_hsa04114	0.89516896
48	Propanoate metabolism_Homo sapiens_hsa00640	0.87991103
49	mTOR signaling pathway_Homo sapiens_hsa04150	0.86215113
50	Phototransduction_Homo sapiens_hsa04744	0.85612575
51	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.82341699
52	Lysine degradation_Homo sapiens_hsa00310	0.78622799
53	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.77680965
54	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.74301717
55	Purine metabolism_Homo sapiens_hsa00230	0.73895160
56	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.71052534
57	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.70621736
58	Fatty acid degradation_Homo sapiens_hsa00071	0.67694252
59	Insulin secretion_Homo sapiens_hsa04911	0.67565419
60	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.62823400
61	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.60533458
62	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.55653873
63	Chemical carcinogenesis_Homo sapiens_hsa05204	0.55577606
64	Base excision repair_Homo sapiens_hsa03410	0.54242774
65	Folate biosynthesis_Homo sapiens_hsa00790	0.52276096
66	Metabolic pathways_Homo sapiens_hsa01100	0.50247572
67	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.49709297
68	Circadian rhythm_Homo sapiens_hsa04710	0.47456591
69	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.46309879
70	Mineral absorption_Homo sapiens_hsa04978	0.46269785
71	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.45154344
72	Thyroid cancer_Homo sapiens_hsa05216	0.44791166
73	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.44362215
74	Caffeine metabolism_Homo sapiens_hsa00232	0.43152842
75	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.42608973
76	Peroxisome_Homo sapiens_hsa04146	0.42578670
77	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.42414844
78	Retinol metabolism_Homo sapiens_hsa00830	0.41525874
79	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.41393059
80	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.36991389
81	Sulfur relay system_Homo sapiens_hsa04122	0.34078131
82	Olfactory transduction_Homo sapiens_hsa04740	0.32953691
83	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.32140597
84	Vibrio cholerae infection_Homo sapiens_hsa05110	0.31871116
85	Type II diabetes mellitus_Homo sapiens_hsa04930	0.30822570
86	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.30141592
87	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.30022199
88	Salivary secretion_Homo sapiens_hsa04970	0.27495161
89	Melanoma_Homo sapiens_hsa05218	0.27475967
90	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.26659348
91	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.25372749
92	beta-Alanine metabolism_Homo sapiens_hsa00410	0.25230632
93	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.22572567
94	Pyruvate metabolism_Homo sapiens_hsa00620	0.21118946
95	Amphetamine addiction_Homo sapiens_hsa05031	0.19633909
96	Prostate cancer_Homo sapiens_hsa05215	0.18918404
97	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.17460287
98	Glutathione metabolism_Homo sapiens_hsa00480	0.17418970
99	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.17066373
100	Arginine biosynthesis_Homo sapiens_hsa00220	0.16187414

NANOGNBP3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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