ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	piRNA metabolic process (GO:0034587)	4.94462799
2	behavioral response to nicotine (GO:0035095)	4.50931457
3	regulation of meiosis I (GO:0060631)	4.40839591
4	protein-cofactor linkage (GO:0018065)	4.33475992
5	protein complex biogenesis (GO:0070271)	3.83615635
6	protein K11-linked deubiquitination (GO:0035871)	3.82294872
7	DNA double-strand break processing (GO:0000729)	3.79978155
8	mitochondrial respiratory chain complex assembly (GO:0033108)	3.72989219
9	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.72389768
10	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.68103799
11	respiratory chain complex IV assembly (GO:0008535)	3.67240901
12	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.64142356
13	NADH dehydrogenase complex assembly (GO:0010257)	3.64142356
14	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.64142356
15	proteasome assembly (GO:0043248)	3.54412689
16	synapsis (GO:0007129)	3.50750820
17	pseudouridine synthesis (GO:0001522)	3.46798565
18	fucose catabolic process (GO:0019317)	3.44389087
19	L-fucose metabolic process (GO:0042354)	3.44389087
20	L-fucose catabolic process (GO:0042355)	3.44389087
21	platelet dense granule organization (GO:0060155)	3.42530416
22	cytochrome complex assembly (GO:0017004)	3.39114026
23	indole-containing compound catabolic process (GO:0042436)	3.39061192
24	indolalkylamine catabolic process (GO:0046218)	3.39061192
25	tryptophan catabolic process (GO:0006569)	3.39061192
26	sulfation (GO:0051923)	3.37844701
27	water-soluble vitamin biosynthetic process (GO:0042364)	3.36465910
28	DNA methylation involved in gamete generation (GO:0043046)	3.35686539
29	maturation of 5.8S rRNA (GO:0000460)	3.33548911
30	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.24304257
31	regulation of posttranscriptional gene silencing (GO:0060147)	3.23557448
32	regulation of gene silencing by miRNA (GO:0060964)	3.23557448
33	regulation of gene silencing by RNA (GO:0060966)	3.23557448
34	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.22898297
35	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.22898297
36	DNA deamination (GO:0045006)	3.22206730
37	peptidyl-histidine modification (GO:0018202)	3.20487528
38	male meiosis I (GO:0007141)	3.17922497
39	negative regulation of telomere maintenance (GO:0032205)	3.13996222
40	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.12779872
41	male meiosis (GO:0007140)	3.10703105
42	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.05416672
43	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.05416672
44	glycerophospholipid catabolic process (GO:0046475)	3.01928433
45	termination of RNA polymerase III transcription (GO:0006386)	3.00724026
46	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.00724026
47	kynurenine metabolic process (GO:0070189)	2.99801999
48	retinal cone cell development (GO:0046549)	2.94876806
49	rRNA catabolic process (GO:0016075)	2.92619870
50	positive regulation of meiosis (GO:0045836)	2.92069883
51	indolalkylamine metabolic process (GO:0006586)	2.91461210
52	protein K6-linked ubiquitination (GO:0085020)	2.89453481
53	ubiquinone biosynthetic process (GO:0006744)	2.89037782
54	replication fork processing (GO:0031297)	2.88942957
55	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.87946327
56	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.83368677
57	protein neddylation (GO:0045116)	2.79189777
58	positive regulation of meiotic cell cycle (GO:0051446)	2.75908077
59	mannosylation (GO:0097502)	2.75765236
60	tryptophan metabolic process (GO:0006568)	2.73462113
61	reciprocal DNA recombination (GO:0035825)	2.72956050
62	reciprocal meiotic recombination (GO:0007131)	2.72956050
63	mitochondrial RNA metabolic process (GO:0000959)	2.70327308
64	protein deneddylation (GO:0000338)	2.66440456
65	tRNA processing (GO:0008033)	2.65937787
66	ubiquinone metabolic process (GO:0006743)	2.64650875
67	cullin deneddylation (GO:0010388)	2.63065671
68	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.61694647
69	DNA replication checkpoint (GO:0000076)	2.60929424
70	serotonin receptor signaling pathway (GO:0007210)	2.58488832
71	reflex (GO:0060004)	2.57889268
72	neural tube formation (GO:0001841)	2.55799708
73	meiosis I (GO:0007127)	2.52534060
74	rhodopsin mediated signaling pathway (GO:0016056)	2.50736956
75	recombinational repair (GO:0000725)	2.50601026
76	DNA catabolic process, exonucleolytic (GO:0000738)	2.49854953
77	presynaptic membrane assembly (GO:0097105)	2.49363745
78	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.48192102
79	regulation of translation, ncRNA-mediated (GO:0045974)	2.48192102
80	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.48192102
81	double-strand break repair via homologous recombination (GO:0000724)	2.47970480
82	axoneme assembly (GO:0035082)	2.47770576
83	neuronal action potential (GO:0019228)	2.47362566
84	detection of light stimulus involved in sensory perception (GO:0050962)	2.47272163
85	detection of light stimulus involved in visual perception (GO:0050908)	2.47272163
86	dopamine transport (GO:0015872)	2.47019742
87	regulation of mesoderm development (GO:2000380)	2.46816988
88	photoreceptor cell maintenance (GO:0045494)	2.46322358
89	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.46086420
90	preassembly of GPI anchor in ER membrane (GO:0016254)	2.45075397
91	indole-containing compound metabolic process (GO:0042430)	2.42114126
92	kidney morphogenesis (GO:0060993)	2.41872378
93	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.41101187
94	cellular ketone body metabolic process (GO:0046950)	2.41017778
95	response to pheromone (GO:0019236)	2.40508314
96	cilium morphogenesis (GO:0060271)	2.39003116
97	regulation of mitochondrial translation (GO:0070129)	2.38553573
98	photoreceptor cell development (GO:0042461)	2.38095670
99	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.38085606
100	ATP synthesis coupled proton transport (GO:0015986)	2.37668451

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.18129465
2	VDR_22108803_ChIP-Seq_LS180_Human	3.63066058
3	GBX2_23144817_ChIP-Seq_PC3_Human	2.95327106
4	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.80268718
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.76846250
6	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.70807460
7	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.61256319
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.46568646
9	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.45507819
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.43546920
11	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.37492711
12	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.32078223
13	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.29151933
14	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.20445739
15	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.13498037
16	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.07867536
17	EWS_26573619_Chip-Seq_HEK293_Human	2.07593755
18	FUS_26573619_Chip-Seq_HEK293_Human	1.95890774
19	P300_19829295_ChIP-Seq_ESCs_Human	1.94390855
20	TAF15_26573619_Chip-Seq_HEK293_Human	1.87839549
21	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.85458689
22	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.85208589
23	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.77704396
24	IRF1_19129219_ChIP-ChIP_H3396_Human	1.75497114
25	ER_23166858_ChIP-Seq_MCF-7_Human	1.67769356
26	MYC_18940864_ChIP-ChIP_HL60_Human	1.63317632
27	TP53_22573176_ChIP-Seq_HFKS_Human	1.62931999
28	VDR_23849224_ChIP-Seq_CD4+_Human	1.60605318
29	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.55393988
30	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.54683279
31	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.51055890
32	ELK1_19687146_ChIP-ChIP_HELA_Human	1.48598905
33	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.46422084
34	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.45186506
35	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.45012819
36	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.45012819
37	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.44858767
38	BCAT_22108803_ChIP-Seq_LS180_Human	1.41198322
39	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.36940079
40	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.35961085
41	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.34212584
42	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.34043520
43	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.33923594
44	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.32858369
45	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.32676977
46	STAT3_23295773_ChIP-Seq_U87_Human	1.31648569
47	AR_25329375_ChIP-Seq_VCAP_Human	1.31320128
48	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.31036023
49	NANOG_19829295_ChIP-Seq_ESCs_Human	1.31031853
50	SOX2_19829295_ChIP-Seq_ESCs_Human	1.31031853
51	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.27472736
52	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.26853909
53	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.26399589
54	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.25917924
55	TCF4_23295773_ChIP-Seq_U87_Human	1.25076103
56	SMAD4_21799915_ChIP-Seq_A2780_Human	1.24935216
57	TCF4_22108803_ChIP-Seq_LS180_Human	1.23873497
58	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.22597476
59	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.21252559
60	CBP_20019798_ChIP-Seq_JUKART_Human	1.20846924
61	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.20846924
62	FOXP3_21729870_ChIP-Seq_TREG_Human	1.20783668
63	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.20437185
64	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.19908195
65	RNF2_27304074_Chip-Seq_NSC_Mouse	1.19727469
66	AR_20517297_ChIP-Seq_VCAP_Human	1.18838313
67	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.18100982
68	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.17739692
69	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.17570437
70	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.16786621
71	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.16612631
72	RUNX2_22187159_ChIP-Seq_PCA_Human	1.16243712
73	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.15588587
74	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.13914702
75	HOXB7_26014856_ChIP-Seq_BT474_Human	1.13130802
76	NCOR_22424771_ChIP-Seq_293T_Human	1.12511327
77	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.10847013
78	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.10819946
79	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.07033854
80	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.07033854
81	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.05965297
82	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.05850585
83	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.05829115
84	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.04625083
85	REST_21632747_ChIP-Seq_MESCs_Mouse	1.04046160
86	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.02743877
87	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.02032943
88	EZH2_22144423_ChIP-Seq_EOC_Human	1.01174513
89	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.00709881
90	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.00466546
91	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.00221785
92	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.98563145
93	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.97884669
94	RBPJ_22232070_ChIP-Seq_NCS_Mouse	0.96747017
95	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	0.96377090
96	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.96012889
97	CDX2_22108803_ChIP-Seq_LS180_Human	0.95733547
98	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.95374791
99	MYC_19829295_ChIP-Seq_ESCs_Human	0.93964062
100	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.93582787

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.71993089
2	MP0005551_abnormal_eye_electrophysiolog	2.61780718
3	MP0003195_calcinosis	2.52631432
4	MP0002736_abnormal_nociception_after	2.45259237
5	MP0002254_reproductive_system_inflammat	2.45124855
6	MP0001968_abnormal_touch/_nociception	2.34633977
7	MP0004147_increased_porphyrin_level	2.21654608
8	MP0002102_abnormal_ear_morphology	2.17825363
9	MP0002837_dystrophic_cardiac_calcinosis	2.14818344
10	MP0003787_abnormal_imprinting	2.12941310
11	MP0006072_abnormal_retinal_apoptosis	2.11509194
12	MP0003136_yellow_coat_color	2.11484239
13	MP0008058_abnormal_DNA_repair	2.00884943
14	MP0008875_abnormal_xenobiotic_pharmacok	1.97776456
15	MP0006292_abnormal_olfactory_placode	1.92180363
16	MP0004133_heterotaxia	1.85050702
17	MP0002876_abnormal_thyroid_physiology	1.80132847
18	MP0000569_abnormal_digit_pigmentation	1.79129128
19	MP0001501_abnormal_sleep_pattern	1.77991485
20	MP0009745_abnormal_behavioral_response	1.77038547
21	MP0008872_abnormal_physiological_respon	1.75047473
22	MP0004142_abnormal_muscle_tone	1.73388724
23	MP0005084_abnormal_gallbladder_morpholo	1.71358955
24	MP0003718_maternal_effect	1.71042319
25	MP0009046_muscle_twitch	1.70139696
26	MP0002938_white_spotting	1.69663498
27	MP0005253_abnormal_eye_physiology	1.68786829
28	MP0000427_abnormal_hair_cycle	1.62839825
29	MP0002163_abnormal_gland_morphology	1.61755419
30	MP0003011_delayed_dark_adaptation	1.61555809
31	MP0005379_endocrine/exocrine_gland_phen	1.56937539
32	MP0004885_abnormal_endolymph	1.55858288
33	MP0005645_abnormal_hypothalamus_physiol	1.54873342
34	MP0002638_abnormal_pupillary_reflex	1.51622780
35	MP0005174_abnormal_tail_pigmentation	1.47716505
36	MP0000372_irregular_coat_pigmentation	1.47610693
37	MP0002272_abnormal_nervous_system	1.47303811
38	MP0000566_synostosis	1.46302098
39	MP0000631_abnormal_neuroendocrine_gland	1.45557262
40	MP0001485_abnormal_pinna_reflex	1.39192849
41	MP0003890_abnormal_embryonic-extraembry	1.37116395
42	MP0003806_abnormal_nucleotide_metabolis	1.36287157
43	MP0002160_abnormal_reproductive_system	1.35209141
44	MP0003646_muscle_fatigue	1.35038041
45	MP0001986_abnormal_taste_sensitivity	1.34756509
46	MP0005075_abnormal_melanosome_morpholog	1.33837170
47	MP0000647_abnormal_sebaceous_gland	1.32864862
48	MP0001529_abnormal_vocalization	1.31690691
49	MP0005389_reproductive_system_phenotype	1.29595742
50	MP0002138_abnormal_hepatobiliary_system	1.28827623
51	MP0010386_abnormal_urinary_bladder	1.28047429
52	MP0002277_abnormal_respiratory_mucosa	1.27543860
53	MP0002210_abnormal_sex_determination	1.22012978
54	MP0002064_seizures	1.21945058
55	MP0005646_abnormal_pituitary_gland	1.21844630
56	MP0003693_abnormal_embryo_hatching	1.21319310
57	MP0000383_abnormal_hair_follicle	1.18534173
58	MP0001486_abnormal_startle_reflex	1.18275240
59	MP0001929_abnormal_gametogenesis	1.17766391
60	MP0001764_abnormal_homeostasis	1.16977966
61	MP0010094_abnormal_chromosome_stability	1.15555532
62	MP0003567_abnormal_fetal_cardiomyocyte	1.12331161
63	MP0006276_abnormal_autonomic_nervous	1.10580121
64	MP0003698_abnormal_male_reproductive	1.08934530
65	MP0002735_abnormal_chemical_nociception	1.07737220
66	MP0004043_abnormal_pH_regulation	1.06399661
67	MP0002572_abnormal_emotion/affect_behav	1.03488662
68	MP0000653_abnormal_sex_gland	1.02998351
69	MP0003880_abnormal_central_pattern	1.02105523
70	MP0002557_abnormal_social/conspecific_i	1.00317069
71	MP0006035_abnormal_mitochondrial_morpho	0.99417032
72	MP0005386_behavior/neurological_phenoty	0.99166937
73	MP0004924_abnormal_behavior	0.99166937
74	MP0005332_abnormal_amino_acid	0.97468004
75	MP0002928_abnormal_bile_duct	0.97277816
76	MP0001145_abnormal_male_reproductive	0.96201571
77	MP0001293_anophthalmia	0.95985998
78	MP0003121_genomic_imprinting	0.95499272
79	MP0009780_abnormal_chondrocyte_physiolo	0.94141111
80	MP0001188_hyperpigmentation	0.94126406
81	MP0001919_abnormal_reproductive_system	0.93364114
82	MP0001984_abnormal_olfaction	0.91533265
83	MP0004145_abnormal_muscle_electrophysio	0.91264270
84	MP0002095_abnormal_skin_pigmentation	0.90477051
85	MP0001970_abnormal_pain_threshold	0.90077811
86	MP0005195_abnormal_posterior_eye	0.89708264
87	MP0005085_abnormal_gallbladder_physiolo	0.89319536
88	MP0003186_abnormal_redox_activity	0.89166113
89	MP0004957_abnormal_blastocyst_morpholog	0.89093423
90	MP0005365_abnormal_bile_salt	0.88953550
91	MP0003937_abnormal_limbs/digits/tail_de	0.88205330
92	MP0004215_abnormal_myocardial_fiber	0.84885869
93	MP0002067_abnormal_sensory_capabilities	0.82978883
94	MP0002734_abnormal_mechanical_nocicepti	0.82832342
95	MP0004742_abnormal_vestibular_system	0.82775611
96	MP0008995_early_reproductive_senescence	0.82559107
97	MP0001324_abnormal_eye_pigmentation	0.81856542
98	MP0010329_abnormal_lipoprotein_level	0.81308015
99	MP0002909_abnormal_adrenal_gland	0.80527965
100	MP0002653_abnormal_ependyma_morphology	0.79828793

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	3.89794600
2	Congenital stationary night blindness (HP:0007642)	3.67213191
3	True hermaphroditism (HP:0010459)	3.65673180
4	Pancreatic fibrosis (HP:0100732)	3.61727665
5	Abnormality of midbrain morphology (HP:0002418)	3.47020216
6	Molar tooth sign on MRI (HP:0002419)	3.47020216
7	Nephronophthisis (HP:0000090)	2.99541082
8	Abnormality of the labia minora (HP:0012880)	2.96991199
9	Abnormality of alanine metabolism (HP:0010916)	2.94871322
10	Hyperalaninemia (HP:0003348)	2.94871322
11	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.94871322
12	Abolished electroretinogram (ERG) (HP:0000550)	2.89557167
13	Hyperglycinuria (HP:0003108)	2.88109679
14	Congenital, generalized hypertrichosis (HP:0004540)	2.75230293
15	Attenuation of retinal blood vessels (HP:0007843)	2.74620803
16	Acute necrotizing encephalopathy (HP:0006965)	2.69467668
17	Polydipsia (HP:0001959)	2.65767277
18	Abnormal drinking behavior (HP:0030082)	2.65767277
19	Progressive inability to walk (HP:0002505)	2.61425645
20	Increased CSF lactate (HP:0002490)	2.60316249
21	Type II lissencephaly (HP:0007260)	2.59090116
22	Abnormality of the renal cortex (HP:0011035)	2.56069878
23	Pendular nystagmus (HP:0012043)	2.55554443
24	Medial flaring of the eyebrow (HP:0010747)	2.54497587
25	Acute encephalopathy (HP:0006846)	2.54289333
26	Abnormality of the renal medulla (HP:0100957)	2.44734201
27	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.44576220
28	Progressive macrocephaly (HP:0004481)	2.41506469
29	Mitochondrial inheritance (HP:0001427)	2.39831294
30	Inability to walk (HP:0002540)	2.36003916
31	Abnormal biliary tract physiology (HP:0012439)	2.35627374
32	Bile duct proliferation (HP:0001408)	2.35627374
33	Methylmalonic acidemia (HP:0002912)	2.31483362
34	Abnormality of the pons (HP:0007361)	2.30804649
35	Cystic liver disease (HP:0006706)	2.29290022
36	Hyperventilation (HP:0002883)	2.29153370
37	Hypoplasia of the pons (HP:0012110)	2.28917708
38	Asplenia (HP:0001746)	2.26683163
39	Abnormality of glycine metabolism (HP:0010895)	2.25920658
40	Abnormality of serine family amino acid metabolism (HP:0010894)	2.25920658
41	Hyperglycinemia (HP:0002154)	2.25375128
42	Bilateral microphthalmos (HP:0007633)	2.24647608
43	Lipid accumulation in hepatocytes (HP:0006561)	2.24421967
44	Abnormal mitochondria in muscle tissue (HP:0008316)	2.22854074
45	Tubular atrophy (HP:0000092)	2.20506557
46	Methylmalonic aciduria (HP:0012120)	2.18427851
47	Chronic hepatic failure (HP:0100626)	2.18313174
48	Gaze-evoked nystagmus (HP:0000640)	2.16442799
49	Abnormal rod and cone electroretinograms (HP:0008323)	2.15746892
50	Increased hepatocellular lipid droplets (HP:0006565)	2.13470839
51	Male pseudohermaphroditism (HP:0000037)	2.11764164
52	Increased corneal curvature (HP:0100692)	2.08238887
53	Keratoconus (HP:0000563)	2.08238887
54	Polyuria (HP:0000103)	2.06816191
55	Decreased central vision (HP:0007663)	2.06251068
56	Stomach cancer (HP:0012126)	2.05163002
57	Optic disc pallor (HP:0000543)	2.05125291
58	Birth length less than 3rd percentile (HP:0003561)	2.01982517
59	Hypomagnesemia (HP:0002917)	2.01767362
60	Abnormality of serum amino acid levels (HP:0003112)	2.01252095
61	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.01178458
62	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.00978788
63	Increased serum lactate (HP:0002151)	1.97721579
64	Furrowed tongue (HP:0000221)	1.96773180
65	Genital tract atresia (HP:0001827)	1.95015439
66	Gait imbalance (HP:0002141)	1.94946061
67	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.94924013
68	Sclerocornea (HP:0000647)	1.94067244
69	Renal cortical cysts (HP:0000803)	1.93887203
70	Congenital primary aphakia (HP:0007707)	1.93710604
71	Anencephaly (HP:0002323)	1.93614348
72	Intestinal atresia (HP:0011100)	1.91445588
73	Hepatocellular necrosis (HP:0001404)	1.89322358
74	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.87225792
75	Decreased circulating renin level (HP:0003351)	1.86520594
76	Vaginal atresia (HP:0000148)	1.86186290
77	Lactic acidosis (HP:0003128)	1.84982744
78	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.83639842
79	Abnormal number of erythroid precursors (HP:0012131)	1.82481928
80	Nephrogenic diabetes insipidus (HP:0009806)	1.79366873
81	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.77218417
82	3-Methylglutaconic aciduria (HP:0003535)	1.76933422
83	Colon cancer (HP:0003003)	1.76206266
84	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.75424155
85	Hypoplasia of the fovea (HP:0007750)	1.75424155
86	Cerebral edema (HP:0002181)	1.75357235
87	Gastrointestinal atresia (HP:0002589)	1.74508645
88	Lethargy (HP:0001254)	1.74508096
89	Hepatic necrosis (HP:0002605)	1.71668774
90	Aplasia/hypoplasia of the uterus (HP:0008684)	1.71489269
91	Homocystinuria (HP:0002156)	1.70925626
92	Abnormality of homocysteine metabolism (HP:0010919)	1.70925626
93	Bony spicule pigmentary retinopathy (HP:0007737)	1.70675025
94	Lissencephaly (HP:0001339)	1.70529133
95	Abnormality of vitamin B metabolism (HP:0004340)	1.69935647
96	Meckel diverticulum (HP:0002245)	1.67009091
97	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.66907603
98	Congenital sensorineural hearing impairment (HP:0008527)	1.65874808
99	Abnormality of the ileum (HP:0001549)	1.65594388
100	Prominent supraorbital ridges (HP:0000336)	1.64698809

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.59495804
2	ACVR1B	3.84997637
3	WNK3	3.00237127
4	ZAK	2.88961269
5	PINK1	2.58141531
6	ADRBK2	2.55439699
7	GRK1	2.37038447
8	NUAK1	2.26750677
9	BMPR1B	2.22659775
10	WNK4	2.22432931
11	MST4	2.10482876
12	OXSR1	2.05757073
13	STK39	1.97997070
14	MKNK2	1.86190943
15	MAP4K2	1.68908723
16	FGFR2	1.67472481
17	INSRR	1.60708858
18	TXK	1.58896843
19	PNCK	1.51783159
20	TLK1	1.39964857
21	MAPK13	1.37570819
22	PBK	1.35976954
23	TSSK6	1.32371566
24	PHKG1	1.30285141
25	PHKG2	1.30285141
26	TRIM28	1.22606036
27	PLK3	1.20247800
28	EIF2AK3	1.19710016
29	BRSK2	1.18267793
30	MKNK1	1.16188430
31	VRK1	1.15050880
32	NME1	1.11925096
33	MUSK	1.10829677
34	STK16	1.10482794
35	CASK	1.09445259
36	TAF1	1.09173453
37	VRK2	1.05709345
38	STK38L	1.05666547
39	CDK19	1.00936808
40	DYRK2	1.00435596
41	TAOK3	0.99523338
42	DAPK2	0.96328500
43	BCKDK	0.96271675
44	PAK3	0.93603820
45	PLK4	0.92223567
46	TNIK	0.91136508
47	MAP3K4	0.89506258
48	ADRBK1	0.89404462
49	NTRK3	0.88674750
50	PRKCE	0.86764709
51	BUB1	0.85219196
52	PLK1	0.83835027
53	TTK	0.81080311
54	CAMKK2	0.81026513
55	CSNK1G1	0.80814934
56	WEE1	0.80180127
57	PRKCG	0.80114339
58	CDC7	0.75603713
59	PLK2	0.75408011
60	TIE1	0.74458513
61	CSNK1G2	0.73975799
62	TGFBR1	0.73649361
63	STK3	0.73609439
64	PDK2	0.69569698
65	MAP2K6	0.65910442
66	CHEK2	0.63210326
67	IRAK1	0.59904551
68	CSNK1G3	0.57581103
69	BCR	0.57060833
70	KIT	0.54651407
71	MAPKAPK3	0.54161809
72	ERBB3	0.53409234
73	TEC	0.53136416
74	SRPK1	0.52150932
75	CDK3	0.50466614
76	PRKCQ	0.49153179
77	ATR	0.48948849
78	FER	0.45487908
79	IKBKB	0.43520926
80	NEK1	0.43055930
81	CSNK1A1	0.42369413
82	PTK2B	0.42317115
83	PIK3CA	0.41937177
84	MARK1	0.41753913
85	PASK	0.41341722
86	PRKCI	0.41284891
87	CAMK1	0.40508929
88	CAMK2A	0.40086418
89	EPHA4	0.39546574
90	PRKACA	0.39196834
91	RPS6KA5	0.39043314
92	ATM	0.37014934
93	STK24	0.35501086
94	STK4	0.34274315
95	TRPM7	0.33584586
96	PKN1	0.32947769
97	PRKCA	0.32150681
98	IGF1R	0.31609372
99	EIF2AK2	0.31415923
100	MAPKAPK5	0.30562719

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	2.62380779
2	Selenocompound metabolism_Homo sapiens_hsa00450	2.57847228
3	Oxidative phosphorylation_Homo sapiens_hsa00190	2.57302302
4	RNA polymerase_Homo sapiens_hsa03020	2.53693137
5	Basal transcription factors_Homo sapiens_hsa03022	2.31758580
6	Homologous recombination_Homo sapiens_hsa03440	2.29027034
7	Linoleic acid metabolism_Homo sapiens_hsa00591	2.26454851
8	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.20674281
9	Protein export_Homo sapiens_hsa03060	2.19477894
10	Proteasome_Homo sapiens_hsa03050	2.12785597
11	Parkinsons disease_Homo sapiens_hsa05012	2.02822672
12	Butanoate metabolism_Homo sapiens_hsa00650	1.93161375
13	Non-homologous end-joining_Homo sapiens_hsa03450	1.90722074
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.85230718
15	One carbon pool by folate_Homo sapiens_hsa00670	1.83923295
16	Nitrogen metabolism_Homo sapiens_hsa00910	1.82203306
17	Fanconi anemia pathway_Homo sapiens_hsa03460	1.80220888
18	Nicotine addiction_Homo sapiens_hsa05033	1.74611265
19	Ether lipid metabolism_Homo sapiens_hsa00565	1.73537011
20	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.72483825
21	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.71667372
22	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.70968419
23	Propanoate metabolism_Homo sapiens_hsa00640	1.70031120
24	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.65216008
25	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.62801331
26	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.62347107
27	Tryptophan metabolism_Homo sapiens_hsa00380	1.59502425
28	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.56912014
29	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.54529364
30	RNA degradation_Homo sapiens_hsa03018	1.54294229
31	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.52067218
32	Caffeine metabolism_Homo sapiens_hsa00232	1.52019653
33	Huntingtons disease_Homo sapiens_hsa05016	1.47979348
34	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.22393506
35	Alzheimers disease_Homo sapiens_hsa05010	1.21656328
36	Ribosome_Homo sapiens_hsa03010	1.19602963
37	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.17565494
38	Olfactory transduction_Homo sapiens_hsa04740	1.11939325
39	Mismatch repair_Homo sapiens_hsa03430	1.11130647
40	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.10827235
41	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.09050998
42	Purine metabolism_Homo sapiens_hsa00230	1.08610027
43	Peroxisome_Homo sapiens_hsa04146	1.08411903
44	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.04024960
45	Pyrimidine metabolism_Homo sapiens_hsa00240	1.03952483
46	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.01255978
47	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.01017715
48	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.00434234
49	RNA transport_Homo sapiens_hsa03013	1.00403398
50	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.98186380
51	Taste transduction_Homo sapiens_hsa04742	0.98024840
52	Base excision repair_Homo sapiens_hsa03410	0.97217402
53	Folate biosynthesis_Homo sapiens_hsa00790	0.97127876
54	beta-Alanine metabolism_Homo sapiens_hsa00410	0.95125992
55	Nucleotide excision repair_Homo sapiens_hsa03420	0.90367804
56	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.89891778
57	Cardiac muscle contraction_Homo sapiens_hsa04260	0.89718374
58	Collecting duct acid secretion_Homo sapiens_hsa04966	0.89566571
59	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.86907067
60	ABC transporters_Homo sapiens_hsa02010	0.86721288
61	Chemical carcinogenesis_Homo sapiens_hsa05204	0.86468356
62	Retinol metabolism_Homo sapiens_hsa00830	0.85453113
63	Metabolic pathways_Homo sapiens_hsa01100	0.80698363
64	Morphine addiction_Homo sapiens_hsa05032	0.79766682
65	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.79760962
66	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.79399564
67	Fat digestion and absorption_Homo sapiens_hsa04975	0.79376030
68	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.77581982
69	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.77507654
70	Glycerolipid metabolism_Homo sapiens_hsa00561	0.75899852
71	Regulation of autophagy_Homo sapiens_hsa04140	0.75313797
72	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.73673011
73	Fatty acid elongation_Homo sapiens_hsa00062	0.69074952
74	Serotonergic synapse_Homo sapiens_hsa04726	0.67890437
75	DNA replication_Homo sapiens_hsa03030	0.66414417
76	Steroid biosynthesis_Homo sapiens_hsa00100	0.66362925
77	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.65079193
78	Histidine metabolism_Homo sapiens_hsa00340	0.63980056
79	Insulin secretion_Homo sapiens_hsa04911	0.63083407
80	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.62949741
81	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.58679709
82	Sulfur metabolism_Homo sapiens_hsa00920	0.55673541
83	Glutathione metabolism_Homo sapiens_hsa00480	0.54852370
84	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.52825497
85	Mineral absorption_Homo sapiens_hsa04978	0.50708299
86	Pyruvate metabolism_Homo sapiens_hsa00620	0.48501887
87	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.47367712
88	GABAergic synapse_Homo sapiens_hsa04727	0.47113077
89	Fatty acid degradation_Homo sapiens_hsa00071	0.46731577
90	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.46700853
91	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.46525851
92	Fatty acid metabolism_Homo sapiens_hsa01212	0.45722298
93	Primary immunodeficiency_Homo sapiens_hsa05340	0.44739764
94	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.39816006
95	Arginine and proline metabolism_Homo sapiens_hsa00330	0.39339118
96	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.38284810
97	Calcium signaling pathway_Homo sapiens_hsa04020	0.37972648
98	Spliceosome_Homo sapiens_hsa03040	0.37108134
99	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.36289446
100	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.35522256

NANOGP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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