ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	proline biosynthetic process (GO:0006561)	7.64748440
2	inner mitochondrial membrane organization (GO:0007007)	7.27683697
3	receptor catabolic process (GO:0032801)	6.63183792
4	dorsal/ventral axis specification (GO:0009950)	6.25684490
5	attachment of spindle microtubules to kinetochore (GO:0008608)	5.83664483
6	proline metabolic process (GO:0006560)	5.73905383
7	CDP-diacylglycerol biosynthetic process (GO:0016024)	5.49355736
8	regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)	5.31909494
9	positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)	5.31909494
10	transcription from mitochondrial promoter (GO:0006390)	5.29545939
11	righting reflex (GO:0060013)	5.24637341
12	nonmotile primary cilium assembly (GO:0035058)	5.22822620
13	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	5.19413915
14	cullin deneddylation (GO:0010388)	4.87458108
15	CDP-diacylglycerol metabolic process (GO:0046341)	4.77696930
16	single strand break repair (GO:0000012)	4.74839728
17	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	4.74422313
18	cell fate commitment involved in formation of primary germ layer (GO:0060795)	4.72798328
19	estrogen biosynthetic process (GO:0006703)	4.41547741
20	protein deneddylation (GO:0000338)	4.37560428
21	toxin metabolic process (GO:0009404)	4.28576359
22	regulation of acyl-CoA biosynthetic process (GO:0050812)	4.24971495
23	eye photoreceptor cell differentiation (GO:0001754)	4.24367222
24	photoreceptor cell differentiation (GO:0046530)	4.24367222
25	regulation of coenzyme metabolic process (GO:0051196)	4.22537480
26	regulation of cofactor metabolic process (GO:0051193)	4.22537480
27	peptidyl-histidine modification (GO:0018202)	4.15664076
28	negative regulation of cytosolic calcium ion concentration (GO:0051481)	4.15204623
29	mitochondrial fusion (GO:0008053)	4.11614888
30	L-methionine salvage (GO:0071267)	4.09633993
31	L-methionine biosynthetic process (GO:0071265)	4.09633993
32	amino acid salvage (GO:0043102)	4.09633993
33	peptidyl-cysteine modification (GO:0018198)	4.07673170
34	histone H2A monoubiquitination (GO:0035518)	4.01836407
35	kidney morphogenesis (GO:0060993)	3.95300002
36	glycosphingolipid biosynthetic process (GO:0006688)	3.92118607
37	ribonucleoprotein complex disassembly (GO:0032988)	3.91983261
38	detection of calcium ion (GO:0005513)	3.68754963
39	epithelial cell fate commitment (GO:0072148)	3.60479619
40	primitive streak formation (GO:0090009)	3.58746009
41	response to pheromone (GO:0019236)	3.45804666
42	ovulation from ovarian follicle (GO:0001542)	3.44834783
43	regulation of clathrin-mediated endocytosis (GO:2000369)	3.41927932
44	renal tubule development (GO:0061326)	3.41451902
45	glycosylceramide metabolic process (GO:0006677)	3.41168577
46	regulation of MHC class I biosynthetic process (GO:0045343)	3.37577833
47	brain morphogenesis (GO:0048854)	3.30566550
48	snRNA transcription (GO:0009301)	3.27959837
49	positive regulation of mRNA 3-end processing (GO:0031442)	3.27002702
50	reflex (GO:0060004)	3.25207958
51	metanephric mesenchyme development (GO:0072075)	3.23745758
52	organelle membrane fusion (GO:0090174)	3.21872449
53	histone H2A ubiquitination (GO:0033522)	3.21204891
54	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.20821146
55	regulation of sulfur metabolic process (GO:0042762)	3.19147905
56	iron ion import (GO:0097286)	3.16221205
57	regulation of timing of cell differentiation (GO:0048505)	3.16169694
58	organelle disassembly (GO:1903008)	3.12251111
59	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.11128004
60	positive regulation of cytokinesis (GO:0032467)	3.09636677
61	DNA double-strand break processing (GO:0000729)	3.08719757
62	natural killer cell activation involved in immune response (GO:0002323)	3.07930848
63	mitochondrial RNA metabolic process (GO:0000959)	3.05115449
64	protein localization to Golgi apparatus (GO:0034067)	3.02659167
65	regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)	2.99341559
66	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)	2.99341559
67	transcription elongation from RNA polymerase I promoter (GO:0006362)	2.98077042
68	regulation of meiosis I (GO:0060631)	2.95823104
69	vascular smooth muscle contraction (GO:0014829)	2.95037910
70	response to acidic pH (GO:0010447)	2.95015275
71	microtubule anchoring (GO:0034453)	2.93948323
72	chaperone-mediated protein transport (GO:0072321)	2.93635895
73	regulation of cell fate commitment (GO:0010453)	2.93238984
74	regulation of mRNA 3-end processing (GO:0031440)	2.93135398
75	gastrulation with mouth forming second (GO:0001702)	2.92221041
76	regulation of mitochondrial translation (GO:0070129)	2.92083121
77	succinate metabolic process (GO:0006105)	2.91206455
78	proteasome assembly (GO:0043248)	2.89523371
79	regulation of development, heterochronic (GO:0040034)	2.88533501
80	positive regulation of mRNA processing (GO:0050685)	2.88158133
81	cellular response to gamma radiation (GO:0071480)	2.87551201
82	termination of RNA polymerase I transcription (GO:0006363)	2.86932366
83	melanosome transport (GO:0032402)	2.84886110
84	signal peptide processing (GO:0006465)	2.83187860
85	response to UV-C (GO:0010225)	2.82811096
86	atrial cardiac muscle cell action potential (GO:0086014)	2.82442514
87	methionine biosynthetic process (GO:0009086)	2.80881559
88	establishment of melanosome localization (GO:0032401)	2.79157943
89	histone H2A acetylation (GO:0043968)	2.78692081
90	tRNA methylation (GO:0030488)	2.78621662
91	pigment granule transport (GO:0051904)	2.75495588
92	protein palmitoylation (GO:0018345)	2.74474632
93	negative regulation of mRNA processing (GO:0050686)	2.74379404
94	regulation of telomere maintenance (GO:0032204)	2.72755763
95	translesion synthesis (GO:0019985)	2.71407480
96	kidney mesenchyme development (GO:0072074)	2.71017123
97	establishment of pigment granule localization (GO:0051905)	2.70424756
98	potassium ion import (GO:0010107)	2.68636261
99	phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)	2.66335192
100	negative regulation of cell fate commitment (GO:0010454)	2.65672969

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.90815548
2	FLI1_27457419_Chip-Seq_LIVER_Mouse	3.58789958
3	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.05286940
4	RBPJ_22232070_ChIP-Seq_NCS_Mouse	3.05188552
5	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.95983489
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.88802635
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.62125249
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.43330481
9	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.39636380
10	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.39502235
11	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.37363340
12	VDR_22108803_ChIP-Seq_LS180_Human	2.36663398
13	IGF1R_20145208_ChIP-Seq_DFB_Human	2.35459130
14	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.35454107
15	FUS_26573619_Chip-Seq_HEK293_Human	2.29163313
16	E2F7_22180533_ChIP-Seq_HELA_Human	2.05178715
17	TAF15_26573619_Chip-Seq_HEK293_Human	2.04465217
18	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.00392384
19	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.97856795
20	P300_19829295_ChIP-Seq_ESCs_Human	1.88452020
21	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.83112659
22	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	1.82412823
23	GBX2_23144817_ChIP-Seq_PC3_Human	1.80453639
24	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.80002021
25	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.79686195
26	BCAT_22108803_ChIP-Seq_LS180_Human	1.79225995
27	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.78290152
28	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.76382830
29	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.71806969
30	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.68661881
31	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.67510649
32	IRF1_19129219_ChIP-ChIP_H3396_Human	1.67011374
33	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.62291956
34	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.62196303
35	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.62196303
36	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.62196303
37	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.60165453
38	EWS_26573619_Chip-Seq_HEK293_Human	1.58807355
39	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.55759529
40	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.51006748
41	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.51006748
42	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.47008947
43	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.43860881
44	NACC1_18358816_ChIP-ChIP_MESCs_Mouse	1.43838843
45	TBX3_20139965_ChIP-Seq_ESCs_Mouse	1.43619273
46	TBX3_20139965_ChIP-Seq_MESCs_Mouse	1.42136912
47	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.42100276
48	ER_23166858_ChIP-Seq_MCF-7_Human	1.40291118
49	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.39990924
50	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.35167806
51	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.34679105
52	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.32416342
53	NANOG_18358816_ChIP-ChIP_MESCs_Mouse	1.31422396
54	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.31018444
55	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.29901289
56	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.26857088
57	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.22569650
58	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.22220805
59	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.22045839
60	ELK1_19687146_ChIP-ChIP_HELA_Human	1.21201277
61	TCF4_22108803_ChIP-Seq_LS180_Human	1.19143732
62	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.18885355
63	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.15941869
64	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.15621986
65	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.14411132
66	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.14242096
67	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.12550130
68	AR_25329375_ChIP-Seq_VCAP_Human	1.12337195
69	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.11915549
70	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.10898844
71	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.10029589
72	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.09982078
73	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.09944389
74	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	1.09619469
75	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.09599393
76	NANOG_19829295_ChIP-Seq_ESCs_Human	1.09023598
77	SOX2_19829295_ChIP-Seq_ESCs_Human	1.09023598
78	POU5F1_18347094_ChIP-ChIP_MESCs_Mouse	1.08910457
79	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.08390144
80	STAT3_23295773_ChIP-Seq_U87_Human	1.07463659
81	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.07399071
82	SALL4_18804426_ChIP-ChIP_MESCs_Mouse	1.07363567
83	VDR_23849224_ChIP-Seq_CD4+_Human	1.07029355
84	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.03173411
85	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.03104563
86	OCT4_18555785_Chip-Seq_ESCs_Mouse	0.98831315
87	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	0.98535760
88	CTCF_18555785_Chip-Seq_ESCs_Mouse	0.97985137
89	TCF3_18692474_ChIP-Seq_MESCs_Mouse	0.96715386
90	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.96586116
91	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.95986466
92	MYC_18940864_ChIP-ChIP_HL60_Human	0.95882802
93	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.95663837
94	CMYC_18555785_Chip-Seq_ESCs_Mouse	0.95239257
95	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.95209570
96	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.93682754
97	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.93376876
98	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.92973198
99	ETS1_20019798_ChIP-Seq_JURKAT_Human	0.92388374
100	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.92342773

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000383_abnormal_hair_follicle	4.46544401
2	MP0010678_abnormal_skin_adnexa	4.10173054
3	MP0002638_abnormal_pupillary_reflex	3.98672951
4	MP0003283_abnormal_digestive_organ	3.74111355
5	MP0003011_delayed_dark_adaptation	3.71413077
6	MP0008057_abnormal_DNA_replication	3.54329403
7	MP0005220_abnormal_exocrine_pancreas	2.82669562
8	MP0010234_abnormal_vibrissa_follicle	2.79087073
9	MP0000427_abnormal_hair_cycle	2.73265514
10	MP0003787_abnormal_imprinting	2.70949060
11	MP0010094_abnormal_chromosome_stability	2.61210041
12	MP0002837_dystrophic_cardiac_calcinosis	2.55058736
13	MP0003890_abnormal_embryonic-extraembry	2.52221434
14	MP0002254_reproductive_system_inflammat	2.51570670
15	MP0006292_abnormal_olfactory_placode	2.40675342
16	MP0008058_abnormal_DNA_repair	2.39392563
17	MP0004957_abnormal_blastocyst_morpholog	2.13399197
18	MP0003941_abnormal_skin_development	1.99219281
19	MP0008995_early_reproductive_senescence	1.97163473
20	MP0005379_endocrine/exocrine_gland_phen	1.94556321
21	MP0008877_abnormal_DNA_methylation	1.87804561
22	MP0003718_maternal_effect	1.83531287
23	MP0004133_heterotaxia	1.79575065
24	MP0000647_abnormal_sebaceous_gland	1.71526236
25	MP0002139_abnormal_hepatobiliary_system	1.68661435
26	MP0003195_calcinosis	1.64583377
27	MP0003937_abnormal_limbs/digits/tail_de	1.61308888
28	MP0002877_abnormal_melanocyte_morpholog	1.60902383
29	MP0009046_muscle_twitch	1.52157721
30	MP0003693_abnormal_embryo_hatching	1.51978584
31	MP0002163_abnormal_gland_morphology	1.51719811
32	MP0005365_abnormal_bile_salt	1.48762184
33	MP0008789_abnormal_olfactory_epithelium	1.48421139
34	MP0003252_abnormal_bile_duct	1.48372720
35	MP0001529_abnormal_vocalization	1.48116508
36	MP0003786_premature_aging	1.45613059
37	MP0006072_abnormal_retinal_apoptosis	1.43623925
38	MP0006035_abnormal_mitochondrial_morpho	1.42494433
39	MP0001485_abnormal_pinna_reflex	1.40513222
40	MP0001293_anophthalmia	1.36423801
41	MP0001984_abnormal_olfaction	1.35838443
42	MP0002090_abnormal_vision	1.34914501
43	MP0010307_abnormal_tumor_latency	1.34399699
44	MP0001286_abnormal_eye_development	1.28085453
45	MP0004885_abnormal_endolymph	1.23286899
46	MP0001501_abnormal_sleep_pattern	1.21770171
47	MP0002693_abnormal_pancreas_physiology	1.17936843
48	MP0005085_abnormal_gallbladder_physiolo	1.17669211
49	MP0005367_renal/urinary_system_phenotyp	1.14503523
50	MP0000516_abnormal_urinary_system	1.14503523
51	MP0005499_abnormal_olfactory_system	1.14353387
52	MP0005394_taste/olfaction_phenotype	1.14353387
53	MP0004270_analgesia	1.11850501
54	MP0001929_abnormal_gametogenesis	1.07960039
55	MP0001730_embryonic_growth_arrest	1.07539930
56	MP0001727_abnormal_embryo_implantation	1.06469802
57	MP0002084_abnormal_developmental_patter	1.05760095
58	MP0002876_abnormal_thyroid_physiology	1.04706847
59	MP0006036_abnormal_mitochondrial_physio	1.04011920
60	MP0002938_white_spotting	1.02569214
61	MP0003077_abnormal_cell_cycle	0.99400675
62	MP0009745_abnormal_behavioral_response	0.97786622
63	MP0000013_abnormal_adipose_tissue	0.97592698
64	MP0008932_abnormal_embryonic_tissue	0.95411542
65	MP0001188_hyperpigmentation	0.92512156
66	MP0010352_gastrointestinal_tract_polyps	0.89746150
67	MP0003880_abnormal_central_pattern	0.89388496
68	MP0003121_genomic_imprinting	0.88839820
69	MP0004019_abnormal_vitamin_homeostasis	0.87861677
70	MP0009703_decreased_birth_body	0.86861117
71	MP0004085_abnormal_heartbeat	0.86643005
72	MP0002210_abnormal_sex_determination	0.85760785
73	MP0001944_abnormal_pancreas_morphology	0.84693795
74	MP0004742_abnormal_vestibular_system	0.80036489
75	MP0005257_abnormal_intraocular_pressure	0.79819286
76	MP0002085_abnormal_embryonic_tissue	0.79244016
77	MP0006276_abnormal_autonomic_nervous	0.79029406
78	MP0005253_abnormal_eye_physiology	0.77281329
79	MP0000569_abnormal_digit_pigmentation	0.77223967
80	MP0005310_abnormal_salivary_gland	0.75665286
81	MP0002697_abnormal_eye_size	0.75005771
82	MP0001145_abnormal_male_reproductive	0.71465902
83	MP0005645_abnormal_hypothalamus_physiol	0.71292934
84	MP0002734_abnormal_mechanical_nocicepti	0.70852653
85	MP0008775_abnormal_heart_ventricle	0.70160789
86	MP0000653_abnormal_sex_gland	0.68489258
87	MP0002909_abnormal_adrenal_gland	0.68446220
88	MP0001697_abnormal_embryo_size	0.67510317
89	MP0001177_atelectasis	0.65760666
90	MP0008007_abnormal_cellular_replicative	0.64952789
91	MP0003635_abnormal_synaptic_transmissio	0.64863274
92	MP0005195_abnormal_posterior_eye	0.63951485
93	MP0002078_abnormal_glucose_homeostasis	0.63741161
94	MP0003111_abnormal_nucleus_morphology	0.63515947
95	MP0002572_abnormal_emotion/affect_behav	0.60781277
96	MP0005395_other_phenotype	0.60620019
97	MP0005501_abnormal_skin_physiology	0.56782613
98	MP0005551_abnormal_eye_electrophysiolog	0.56367134
99	MP0002272_abnormal_nervous_system	0.55169683
100	MP0002086_abnormal_extraembryonic_tissu	0.54166027

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of alanine metabolism (HP:0010916)	5.39359840
2	Hyperalaninemia (HP:0003348)	5.39359840
3	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	5.39359840
4	Gaze-evoked nystagmus (HP:0000640)	5.33383333
5	Medial flaring of the eyebrow (HP:0010747)	5.32385026
6	Dysmetric saccades (HP:0000641)	5.19627680
7	Increased intramyocellular lipid droplets (HP:0012240)	4.94437211
8	Renal Fanconi syndrome (HP:0001994)	4.26805117
9	Sensorimotor neuropathy (HP:0007141)	4.19187083
10	Increased muscle lipid content (HP:0009058)	4.13246947
11	Pancreatic islet-cell hyperplasia (HP:0004510)	3.92700084
12	Increased hepatocellular lipid droplets (HP:0006565)	3.61772768
13	Coronal craniosynostosis (HP:0004440)	3.46460140
14	Spastic paraparesis (HP:0002313)	3.44422366
15	Congenital primary aphakia (HP:0007707)	3.40443310
16	Gait imbalance (HP:0002141)	3.40003746
17	Male infertility (HP:0003251)	3.36669414
18	Progressive external ophthalmoplegia (HP:0000590)	3.35047321
19	Lipid accumulation in hepatocytes (HP:0006561)	3.31160355
20	Hydroureter (HP:0000072)	3.21927365
21	Hypomagnesemia (HP:0002917)	3.18438614
22	Supernumerary spleens (HP:0009799)	3.15110338
23	Nephrogenic diabetes insipidus (HP:0009806)	2.96891799
24	Zonular cataract (HP:0010920)	2.93445664
25	Abnormal rod and cone electroretinograms (HP:0008323)	2.85043855
26	Abnormality of renal resorption (HP:0011038)	2.77583452
27	Persistence of primary teeth (HP:0006335)	2.76821333
28	Palpitations (HP:0001962)	2.71480385
29	Attenuation of retinal blood vessels (HP:0007843)	2.63192328
30	Hypoplasia of the fovea (HP:0007750)	2.63027196
31	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.63027196
32	Poor coordination (HP:0002370)	2.60091249
33	Hypophosphatemic rickets (HP:0004912)	2.53753792
34	Broad-based gait (HP:0002136)	2.46589433
35	Vaginal atresia (HP:0000148)	2.46225349
36	Genital tract atresia (HP:0001827)	2.45602523
37	Limb ataxia (HP:0002070)	2.45462935
38	Neoplasm of the adrenal gland (HP:0100631)	2.44832060
39	Volvulus (HP:0002580)	2.43791536
40	Short foot (HP:0001773)	2.40376957
41	Abnormality of magnesium homeostasis (HP:0004921)	2.38396821
42	Bony spicule pigmentary retinopathy (HP:0007737)	2.34954407
43	Abnormality of saccadic eye movements (HP:0000570)	2.34580044
44	Prominent supraorbital ridges (HP:0000336)	2.28878990
45	Dysdiadochokinesis (HP:0002075)	2.27634271
46	Abnormality of endocrine pancreas physiology (HP:0012093)	2.26517481
47	Abnormality of the pancreatic islet cells (HP:0006476)	2.26517481
48	Abnormality of the fovea (HP:0000493)	2.24312498
49	Abnormality of the labia minora (HP:0012880)	2.23191454
50	Hyperphosphaturia (HP:0003109)	2.21580493
51	Shoulder girdle muscle weakness (HP:0003547)	2.20474003
52	Oculomotor apraxia (HP:0000657)	2.18986094
53	Leukodystrophy (HP:0002415)	2.15416962
54	Confusion (HP:0001289)	2.14257984
55	Intrahepatic cholestasis (HP:0001406)	2.10021125
56	Large for gestational age (HP:0001520)	2.09164900
57	Conjunctival hamartoma (HP:0100780)	2.08698054
58	Ankyloglossia (HP:0010296)	2.08451591
59	Glycosuria (HP:0003076)	2.07470213
60	Abnormality of urine glucose concentration (HP:0011016)	2.07470213
61	Diaphragmatic weakness (HP:0009113)	2.04623675
62	Generalized myoclonic seizures (HP:0002123)	2.03337216
63	Acute necrotizing encephalopathy (HP:0006965)	2.00444354
64	Aplasia/Hypoplasia of the lens (HP:0008063)	2.00159967
65	Disproportionate short-trunk short stature (HP:0003521)	1.98498063
66	Bilateral microphthalmos (HP:0007633)	1.97590632
67	Delusions (HP:0000746)	1.97492385
68	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.95113418
69	Mitochondrial inheritance (HP:0001427)	1.94253376
70	Progressive macrocephaly (HP:0004481)	1.93068527
71	Ovarian neoplasm (HP:0100615)	1.90068864
72	Pelvic girdle muscle weakness (HP:0003749)	1.88329136
73	Ileus (HP:0002595)	1.88316524
74	Lower limb hyperreflexia (HP:0002395)	1.85018208
75	Abnormality of the hip-girdle musculature (HP:0001445)	1.84808902
76	Abnormality of the musculature of the pelvis (HP:0001469)	1.84808902
77	Renal tubular dysfunction (HP:0000124)	1.82899000
78	Abnormal mitochondria in muscle tissue (HP:0008316)	1.82370658
79	Slow saccadic eye movements (HP:0000514)	1.78745903
80	Barrel-shaped chest (HP:0001552)	1.77635666
81	Degeneration of anterior horn cells (HP:0002398)	1.76495343
82	Abnormality of the anterior horn cell (HP:0006802)	1.76495343
83	Abnormality of methionine metabolism (HP:0010901)	1.75819268
84	Increased CSF lactate (HP:0002490)	1.75716034
85	Proximal tubulopathy (HP:0000114)	1.75565938
86	Esophageal neoplasm (HP:0100751)	1.74231040
87	Neoplasm of head and neck (HP:0012288)	1.74231040
88	Aplasia/Hypoplasia of the macula (HP:0008059)	1.73056717
89	Abolished electroretinogram (ERG) (HP:0000550)	1.71859299
90	Urethral obstruction (HP:0000796)	1.68943229
91	Exertional dyspnea (HP:0002875)	1.68075288
92	Rickets (HP:0002748)	1.67876283
93	Broad foot (HP:0001769)	1.67154490
94	Abnormal urine phosphate concentration (HP:0012599)	1.66660686
95	Pheochromocytoma (HP:0002666)	1.66599062
96	Abnormality of serum amino acid levels (HP:0003112)	1.65408563
97	11 pairs of ribs (HP:0000878)	1.64218414
98	Hypoplasia of the pons (HP:0012110)	1.63832351
99	Preaxial foot polydactyly (HP:0001841)	1.61861900
100	Neoplasm of the rectum (HP:0100743)	1.61367086

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ACVR1B	5.57238133
2	MAP3K9	3.27315434
3	FRK	3.00865862
4	BMPR2	2.91534914
5	MAP3K4	2.32325633
6	FGR	2.14446310
7	TAF1	10.1801871
8	TSSK6	1.99955745
9	ERBB3	1.97696086
10	FGFR2	1.71990878
11	SIK2	1.69790122
12	MKNK2	1.65429835
13	MAP3K13	1.51182840
14	CASK	1.49387028
15	PTK2B	1.46906543
16	SGK2	1.42860684
17	PBK	1.41432222
18	ARAF	1.40536226
19	WNK3	1.37807467
20	CLK1	1.32598362
21	STK4	1.27620283
22	KSR2	1.25597516
23	ZAK	1.25526192
24	PNCK	1.17373355
25	SGK3	1.16679315
26	MKNK1	1.14298715
27	SRPK1	1.12054650
28	KSR1	1.11347005
29	DAPK2	1.06972591
30	TTK	1.02674637
31	MST4	0.97565465
32	CDK3	0.96077003
33	PLK3	0.94584459
34	SGK494	0.89141389
35	SGK223	0.89141389
36	ALK	0.84698103
37	TAOK1	0.81907821
38	NEK1	0.79336779
39	NTRK3	0.78285968
40	OXSR1	0.76085523
41	ADRBK2	0.74359648
42	TEC	0.73555575
43	DYRK2	0.73252204
44	CSNK1G1	0.72746238
45	PLK4	0.71931083
46	RAF1	0.70305884
47	NLK	0.63899571
48	DYRK3	0.63835391
49	PINK1	0.61763760
50	PLK1	0.61140156
51	MAPK11	0.60555845
52	BRAF	0.57020969
53	IKBKE	0.56943364
54	WEE1	0.56389360
55	BCR	0.55743795
56	EIF2AK3	0.51430266
57	BUB1	0.50496996
58	TRPM7	0.50356055
59	PRKCE	0.50273242
60	PRKCH	0.48350825
61	STK39	0.47291239
62	SGK1	0.46592657
63	ITK	0.44632375
64	STK38L	0.44311394
65	TAOK3	0.43233688
66	PIM1	0.43061419
67	ATR	0.41730105
68	BCKDK	0.41303232
69	CHEK2	0.39385560
70	PHKG1	0.35884194
71	PHKG2	0.35884194
72	GRK1	0.35420720
73	MOS	0.34542578
74	NUAK1	0.30218673
75	CDK15	0.30186766
76	RPS6KB2	0.30101984
77	NME1	0.30025651
78	NEK2	0.29511186
79	CDK18	0.28997208
80	PLK2	0.27404387
81	PRKACB	0.27057168
82	ERBB4	0.26531765
83	BMX	0.26090598
84	CSNK1E	0.25909611
85	CDC7	0.25387121
86	PRKCG	0.24944365
87	FGFR3	0.24642881
88	FER	0.23804991
89	STK11	0.22490368
90	CDK11A	0.22112591
91	PRKD2	0.21803013
92	BRD4	0.21741072
93	FGFR4	0.21325748
94	CHEK1	0.19565207
95	STK24	0.19222439
96	VRK2	0.18680507
97	CDK14	0.18197515
98	PRKG1	0.17778006
99	PRKACA	0.16333338
100	CSNK1D	0.16262700

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Vitamin B6 metabolism_Homo sapiens_hsa00750	5.18495520
2	Basal transcription factors_Homo sapiens_hsa03022	3.40833690
3	Protein export_Homo sapiens_hsa03060	3.23144004
4	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	3.06778559
5	Ether lipid metabolism_Homo sapiens_hsa00565	2.68713925
6	Proteasome_Homo sapiens_hsa03050	2.59897160
7	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.42099864
8	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.30772355
9	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.15597935
10	Collecting duct acid secretion_Homo sapiens_hsa04966	2.01385199
11	Butanoate metabolism_Homo sapiens_hsa00650	1.93007410
12	Sulfur metabolism_Homo sapiens_hsa00920	1.86827004
13	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.83746034
14	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.83335860
15	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.83216583
16	beta-Alanine metabolism_Homo sapiens_hsa00410	1.82729484
17	Propanoate metabolism_Homo sapiens_hsa00640	1.75240439
18	RNA polymerase_Homo sapiens_hsa03020	1.75110600
19	Fanconi anemia pathway_Homo sapiens_hsa03460	1.61816911
20	Insulin secretion_Homo sapiens_hsa04911	1.55176069
21	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.41584390
22	RNA degradation_Homo sapiens_hsa03018	1.36882217
23	Steroid biosynthesis_Homo sapiens_hsa00100	1.36307525
24	Mineral absorption_Homo sapiens_hsa04978	1.33926217
25	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.32854747
26	Taste transduction_Homo sapiens_hsa04742	1.32317448
27	Mismatch repair_Homo sapiens_hsa03430	1.30349721
28	Retinol metabolism_Homo sapiens_hsa00830	1.27083219
29	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.25678570
30	Oxidative phosphorylation_Homo sapiens_hsa00190	1.22901425
31	Phototransduction_Homo sapiens_hsa04744	1.17392934
32	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.12657709
33	Nucleotide excision repair_Homo sapiens_hsa03420	1.11147145
34	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.10242307
35	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.06377637
36	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.02120768
37	DNA replication_Homo sapiens_hsa03030	1.02066237
38	RNA transport_Homo sapiens_hsa03013	1.01730464
39	Oocyte meiosis_Homo sapiens_hsa04114	1.00437674
40	Pyruvate metabolism_Homo sapiens_hsa00620	0.99354024
41	Homologous recombination_Homo sapiens_hsa03440	0.98128732
42	mRNA surveillance pathway_Homo sapiens_hsa03015	0.97143346
43	Cell cycle_Homo sapiens_hsa04110	0.95305797
44	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.94495151
45	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.93095489
46	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.90889239
47	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.90424222
48	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.89078950
49	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.88571020
50	Glycerolipid metabolism_Homo sapiens_hsa00561	0.87770389
51	Peroxisome_Homo sapiens_hsa04146	0.83537287
52	Base excision repair_Homo sapiens_hsa03410	0.83254629
53	Tryptophan metabolism_Homo sapiens_hsa00380	0.83003497
54	Metabolic pathways_Homo sapiens_hsa01100	0.82779565
55	Wnt signaling pathway_Homo sapiens_hsa04310	0.81132018
56	Spliceosome_Homo sapiens_hsa03040	0.80883704
57	Pyrimidine metabolism_Homo sapiens_hsa00240	0.78537435
58	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.77027637
59	Parkinsons disease_Homo sapiens_hsa05012	0.76994599
60	Serotonergic synapse_Homo sapiens_hsa04726	0.76237485
61	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.73968912
62	p53 signaling pathway_Homo sapiens_hsa04115	0.73829240
63	Renin-angiotensin system_Homo sapiens_hsa04614	0.73769874
64	Purine metabolism_Homo sapiens_hsa00230	0.72153602
65	Cardiac muscle contraction_Homo sapiens_hsa04260	0.72124744
66	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.71967316
67	Non-homologous end-joining_Homo sapiens_hsa03450	0.70470636
68	Sphingolipid metabolism_Homo sapiens_hsa00600	0.70200399
69	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.66896345
70	Vibrio cholerae infection_Homo sapiens_hsa05110	0.65759243
71	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.65191275
72	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.65003189
73	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.63436986
74	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.61718218
75	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.60520619
76	Linoleic acid metabolism_Homo sapiens_hsa00591	0.59314978
77	Huntingtons disease_Homo sapiens_hsa05016	0.56422821
78	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.56265721
79	Alzheimers disease_Homo sapiens_hsa05010	0.55412919
80	Adherens junction_Homo sapiens_hsa04520	0.53990903
81	Arginine and proline metabolism_Homo sapiens_hsa00330	0.50941791
82	Carbon metabolism_Homo sapiens_hsa01200	0.47152200
83	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.47102299
84	One carbon pool by folate_Homo sapiens_hsa00670	0.45000752
85	Nicotine addiction_Homo sapiens_hsa05033	0.44791947
86	Selenocompound metabolism_Homo sapiens_hsa00450	0.44545101
87	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.44200575
88	GABAergic synapse_Homo sapiens_hsa04727	0.44158405
89	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.43345581
90	Tight junction_Homo sapiens_hsa04530	0.43022498
91	Pancreatic secretion_Homo sapiens_hsa04972	0.42809034
92	ABC transporters_Homo sapiens_hsa02010	0.41631288
93	Salivary secretion_Homo sapiens_hsa04970	0.41553673
94	Tyrosine metabolism_Homo sapiens_hsa00350	0.39575575
95	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.39187585
96	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.39063125
97	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.37674299
98	Type I diabetes mellitus_Homo sapiens_hsa04940	0.36658937
99	Circadian entrainment_Homo sapiens_hsa04713	0.36607964
100	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.35744130

NANOGP2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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