NANOGP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ventricular system development (GO:0021591)8.99112010
2regulation of cilium movement (GO:0003352)7.19457688
3left/right pattern formation (GO:0060972)6.14277190
4microtubule bundle formation (GO:0001578)6.00701563
5photoreceptor cell maintenance (GO:0045494)5.49082302
6left/right axis specification (GO:0070986)5.08560540
7hepatocyte differentiation (GO:0070365)4.86991203
8cilium organization (GO:0044782)4.41891453
9microtubule-based movement (GO:0007018)4.16710856
10brain morphogenesis (GO:0048854)4.06844125
11fat-soluble vitamin biosynthetic process (GO:0042362)3.99331368
12regulation of DNA endoreduplication (GO:0032875)3.99304885
13regulation of microtubule-based movement (GO:0060632)3.92344681
14microtubule depolymerization (GO:0007019)3.92195502
15eye photoreceptor cell development (GO:0042462)3.91360520
16peristalsis (GO:0030432)3.76417840
17lateral ventricle development (GO:0021670)3.76253176
18photoreceptor cell development (GO:0042461)3.75686293
19negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.75445111
20negative regulation of translation, ncRNA-mediated (GO:0040033)3.75445111
21regulation of translation, ncRNA-mediated (GO:0045974)3.75445111
22maintenance of gastrointestinal epithelium (GO:0030277)3.57844466
23cellular component assembly involved in morphogenesis (GO:0010927)3.57405187
24cilium assembly (GO:0042384)3.51795259
25intraciliary transport (GO:0042073)3.40379763
26phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.40092509
27establishment of protein localization to Golgi (GO:0072600)3.39978341
28oxidative demethylation (GO:0070989)3.38033828
29interkinetic nuclear migration (GO:0022027)3.36416270
30cilium morphogenesis (GO:0060271)3.33231052
31protein localization to microtubule cytoskeleton (GO:0072698)3.27838995
32peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.22124992
33synaptic vesicle docking involved in exocytosis (GO:0016081)3.04540412
34cilium or flagellum-dependent cell motility (GO:0001539)20.1706583
35early endosome to late endosome transport (GO:0045022)2.97841323
36cell projection assembly (GO:0030031)2.97269634
37multicellular organismal aging (GO:0010259)2.97192361
38protein localization to cilium (GO:0061512)2.95920920
39histone H3-K36 demethylation (GO:0070544)2.91954894
40positive regulation by symbiont of host defense response (GO:0052509)2.91093416
41modulation by symbiont of host defense response (GO:0052031)2.91093416
42modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.91093416
43modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.91093416
44positive regulation by organism of defense response of other organism involved in symbiotic interact2.91093416
45modulation by symbiont of host immune response (GO:0052553)2.91093416
46macrophage activation involved in immune response (GO:0002281)2.90188720
47protein targeting to Golgi (GO:0000042)2.81332747
48microtubule polymerization or depolymerization (GO:0031109)2.80194061
49regulation of interleukin-5 production (GO:0032674)2.78771111
50protein localization to cytoskeleton (GO:0044380)2.77750685
51regulation of gamma-delta T cell differentiation (GO:0045586)2.76813677
52negative regulation of complement activation (GO:0045916)2.76312114
53retrograde transport, vesicle recycling within Golgi (GO:0000301)2.74071090
54kidney morphogenesis (GO:0060993)2.71517612
55epithelial structure maintenance (GO:0010669)2.68405718
56histone H3-K9 demethylation (GO:0033169)2.64280879
57determination of left/right symmetry (GO:0007368)2.62567597
58ubiquinone biosynthetic process (GO:0006744)2.62266126
59pericardium development (GO:0060039)2.61920153
60axis elongation (GO:0003401)2.61839550
61positive regulation of gamma-delta T cell activation (GO:0046645)2.61481513
62T-helper 1 type immune response (GO:0042088)2.56828164
63determination of bilateral symmetry (GO:0009855)2.56126919
64indole-containing compound catabolic process (GO:0042436)2.55948666
65indolalkylamine catabolic process (GO:0046218)2.55948666
66tryptophan catabolic process (GO:0006569)2.55948666
67regulation of pigment cell differentiation (GO:0050932)2.55775542
68exogenous drug catabolic process (GO:0042738)2.55624700
69oxygen transport (GO:0015671)2.55361026
70positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.53897915
71regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.53897915
72nucleus localization (GO:0051647)2.53487830
73negative regulation of protein activation cascade (GO:2000258)2.52427859
74regulation of gamma-delta T cell activation (GO:0046643)2.50658947
75specification of symmetry (GO:0009799)2.49032052
76neural tube formation (GO:0001841)2.48433608
77histone lysine demethylation (GO:0070076)2.45952714
78microtubule-based process (GO:0007017)2.44986739
79kynurenine metabolic process (GO:0070189)2.43959899
80regulation of interleukin-12 biosynthetic process (GO:0045075)2.43736898
81negative regulation of humoral immune response (GO:0002921)2.43090905
82O-glycan processing (GO:0016266)2.42577122
83drug catabolic process (GO:0042737)2.39254798
84response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.36937425
85response to host immune response (GO:0052572)2.36937425
86positive regulation of developmental pigmentation (GO:0048087)2.36206913
87embryonic retina morphogenesis in camera-type eye (GO:0060059)2.35022030
88snRNA transcription (GO:0009301)2.34143251
89ubiquinone metabolic process (GO:0006743)2.31797872
90positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.30556122
91regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.30556122
92single strand break repair (GO:0000012)2.29675281
93epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)15.5920409
94cilium movement (GO:0003341)13.9590464
95retinal rod cell development (GO:0046548)13.8007485
96axoneme assembly (GO:0035082)13.2194684
97retinal cone cell development (GO:0046549)13.0917375
98motile cilium assembly (GO:0044458)12.8939794
99axonemal dynein complex assembly (GO:0070286)12.3778013
100epithelial cilium movement (GO:0003351)10.7967821

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse7.03990796
2AR_21572438_ChIP-Seq_LNCaP_Human4.64732662
3STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse4.60300048
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.09270186
5IGF1R_20145208_ChIP-Seq_DFB_Human3.36823007
6CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.34051768
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.32968259
8SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.19687068
9AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.19318096
10TP53_16413492_ChIP-PET_HCT116_Human2.17270911
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.07093273
12DROSHA_22980978_ChIP-Seq_HELA_Human2.01252582
13SMAD4_21799915_ChIP-Seq_A2780_Human1.99785948
14PIAS1_25552417_ChIP-Seq_VCAP_Human1.98190185
15GATA1_22025678_ChIP-Seq_K562_Human1.92169249
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.87618056
17ZNF217_24962896_ChIP-Seq_MCF-7_Human1.84094371
18FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.81755096
19FOXM1_26456572_ChIP-Seq_MCF-7_Human1.80611840
20STAT3_23295773_ChIP-Seq_U87_Human1.77699884
21GBX2_23144817_ChIP-Seq_PC3_Human1.76549138
22TAF15_26573619_Chip-Seq_HEK293_Human1.71055009
23IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.70397618
24CBP_20019798_ChIP-Seq_JUKART_Human1.70397618
25ARNT_22903824_ChIP-Seq_MCF-7_Human1.66320623
26AHR_22903824_ChIP-Seq_MCF-7_Human1.65149068
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.61629990
28FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.61444871
29POU3F2_20337985_ChIP-ChIP_501MEL_Human1.56141680
30TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.55960307
31NR3C1_21868756_ChIP-Seq_MCF10A_Human1.53192214
32TOP2B_26459242_ChIP-Seq_MCF-7_Human1.52894279
33SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.52804281
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.51737401
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50717018
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49103245
37CTNNB1_20460455_ChIP-Seq_HCT116_Human1.46780401
38SMAD3_21741376_ChIP-Seq_EPCs_Human1.46636665
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.36537364
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34420693
41SMRT_27268052_Chip-Seq_Bcells_Human1.33834936
42FUS_26573619_Chip-Seq_HEK293_Human1.33507539
43MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30553373
44SUZ12_27294783_Chip-Seq_NPCs_Mouse1.30503074
45NFE2_27457419_Chip-Seq_LIVER_Mouse1.28507882
46TCF4_23295773_ChIP-Seq_U87_Human1.28158298
47TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.26181098
48EP300_21415370_ChIP-Seq_HL-1_Mouse1.25945701
49PRDM14_20953172_ChIP-Seq_ESCs_Human1.25473741
50EWS_26573619_Chip-Seq_HEK293_Human1.24492980
51ESR1_20079471_ChIP-ChIP_T-47D_Human1.24059121
52VDR_24787735_ChIP-Seq_THP-1_Human1.22567903
53ER_23166858_ChIP-Seq_MCF-7_Human1.20352329
54AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.20326341
55GATA1_26923725_Chip-Seq_HPCs_Mouse1.20133311
56VDR_22108803_ChIP-Seq_LS180_Human1.19887036
57ELK4_26923725_Chip-Seq_MESODERM_Mouse1.16271404
58GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12103681
59EZH2_27294783_Chip-Seq_NPCs_Mouse1.10868406
60Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.10346507
61AR_25329375_ChIP-Seq_VCAP_Human1.09840594
62P300_19829295_ChIP-Seq_ESCs_Human1.07317472
63SMAD3_21741376_ChIP-Seq_HESCs_Human1.05582087
64RUNX2_22187159_ChIP-Seq_PCA_Human1.04904257
65SMAD4_21741376_ChIP-Seq_EPCs_Human1.04716117
66ZFP57_27257070_Chip-Seq_ESCs_Mouse1.03962070
67TCF4_22108803_ChIP-Seq_LS180_Human1.03742881
68SOX2_21211035_ChIP-Seq_LN229_Gbm1.03531327
69FOXA1_25552417_ChIP-Seq_VCAP_Human1.03350764
70POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03254955
71TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03254955
72FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.02435604
73NANOG_19829295_ChIP-Seq_ESCs_Human1.01777000
74SOX2_19829295_ChIP-Seq_ESCs_Human1.01777000
75KDM2B_26808549_Chip-Seq_REH_Human1.00553400
76PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99854887
77SMAD4_21741376_ChIP-Seq_HESCs_Human0.99513346
78BCAT_22108803_ChIP-Seq_LS180_Human0.98698618
79EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97625050
80SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97304649
81TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97111498
82IRF8_22096565_ChIP-ChIP_GC-B_Human0.95922550
83CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.95766787
84CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.95484454
85UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94900502
86GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.92904697
87SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.91672644
88FOXO3_23340844_ChIP-Seq_DLD1_Human0.91565524
89TP53_18474530_ChIP-ChIP_U2OS_Human0.91251097
90CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.90945732
91RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.90866125
92PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90865736
93AR_19668381_ChIP-Seq_PC3_Human0.90164069
94GATA4_25053715_ChIP-Seq_YYC3_Human0.90086971
95TBL1_22424771_ChIP-Seq_293T_Human0.89570969
96OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89302809
97ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.89286435
98SALL1_21062744_ChIP-ChIP_HESCs_Human0.88548303
99TP63_23658742_ChIP-Seq_EP156T_Human0.87734790
100ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87121351

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology6.00571275
2MP0005083_abnormal_biliary_tract5.59064480
3MP0008057_abnormal_DNA_replication4.69914968
4MP0005623_abnormal_meninges_morphology3.76588196
5MP0000569_abnormal_digit_pigmentation3.46600016
6MP0005253_abnormal_eye_physiology3.40739726
7MP0004043_abnormal_pH_regulation3.00384379
8MP0001666_abnormal_nutrient_absorption2.93061328
9MP0000383_abnormal_hair_follicle2.78409947
10MP0001346_abnormal_lacrimal_gland2.67120152
11MP0008961_abnormal_basal_metabolism2.66149733
12MP0005551_abnormal_eye_electrophysiolog2.38382484
13MP0008875_abnormal_xenobiotic_pharmacok2.36723383
14MP0010368_abnormal_lymphatic_system2.20498665
15MP0005085_abnormal_gallbladder_physiolo2.17653563
16MP0003195_calcinosis2.00221917
17MP0005377_hearing/vestibular/ear_phenot1.99570833
18MP0003878_abnormal_ear_physiology1.99570833
19MP0009115_abnormal_fat_cell1.95166421
20MP0010678_abnormal_skin_adnexa1.92588063
21MP0003045_fibrosis1.85909484
22MP0003950_abnormal_plasma_membrane1.82272205
23MP0008995_early_reproductive_senescence1.78593539
24MP0005220_abnormal_exocrine_pancreas1.75022139
25MP0004145_abnormal_muscle_electrophysio1.69919175
26MP0009046_muscle_twitch1.60954050
27MP0001851_eye_inflammation1.54827037
28MP0010329_abnormal_lipoprotein_level1.51786134
29MP0005365_abnormal_bile_salt1.48409212
30MP0001790_abnormal_immune_system1.47083495
31MP0005387_immune_system_phenotype1.47083495
32MP0005195_abnormal_posterior_eye1.45113275
33MP0002168_other_aberrant_phenotype1.44446999
34MP0005391_vision/eye_phenotype1.43132615
35MP0002405_respiratory_system_inflammati1.40177974
36MP0010352_gastrointestinal_tract_polyps1.38336536
37MP0003690_abnormal_glial_cell1.36396528
38MP0001661_extended_life_span1.26330685
39MP0003959_abnormal_lean_body1.22021187
40MP0002229_neurodegeneration1.18204808
41MP0002282_abnormal_trachea_morphology1.15326896
42MP0003183_abnormal_peptide_metabolism1.15119907
43MP0003868_abnormal_feces_composition1.14830863
44MP0005248_abnormal_Harderian_gland1.14767149
45MP0001879_abnormal_lymphatic_vessel1.14267616
46MP0003646_muscle_fatigue1.13269264
47MP0001486_abnormal_startle_reflex1.10946626
48MP0001324_abnormal_eye_pigmentation1.08749889
49MP0001800_abnormal_humoral_immune1.07977360
50MP0002928_abnormal_bile_duct1.07623225
51MP0009643_abnormal_urine_homeostasis1.04280178
52MP0003656_abnormal_erythrocyte_physiolo1.01951570
53MP0009765_abnormal_xenobiotic_induced0.99707608
54MP0002822_catalepsy0.97541050
55MP0001502_abnormal_circadian_rhythm0.97458449
56MP0002970_abnormal_white_adipose0.94263443
57MP0002118_abnormal_lipid_homeostasis0.93605954
58MP0003866_abnormal_defecation0.92707110
59MP0002135_abnormal_kidney_morphology0.90630807
60MP0005646_abnormal_pituitary_gland0.89358245
61MP0003943_abnormal_hepatobiliary_system0.83287805
62MP0002108_abnormal_muscle_morphology0.82685481
63MP0002136_abnormal_kidney_physiology0.80686764
64MP0003252_abnormal_bile_duct0.79000244
65MP0002933_joint_inflammation0.78932266
66MP0005448_abnormal_energy_balance0.78647126
67MP0005388_respiratory_system_phenotype0.78001476
68MP0002133_abnormal_respiratory_system0.78001476
69MP0000631_abnormal_neuroendocrine_gland0.77437539
70MP0000427_abnormal_hair_cycle0.75956593
71MP0001963_abnormal_hearing_physiology0.74995705
72MP0001944_abnormal_pancreas_morphology0.74366741
73MP0001835_abnormal_antigen_presentation0.70297598
74MP0005266_abnormal_metabolism0.67904663
75MP0005360_urolithiasis0.67551611
76MP0003436_decreased_susceptibility_to0.66675013
77MP0005395_other_phenotype0.65596209
78MP0001663_abnormal_digestive_system0.65513433
79MP0009764_decreased_sensitivity_to0.64973850
80MP0002452_abnormal_antigen_presenting0.63477544
81MP0005310_abnormal_salivary_gland0.61747195
82MP0005164_abnormal_response_to0.61553945
83MP0001177_atelectasis0.61497275
84MP0008873_increased_physiological_sensi0.61096708
85MP0006082_CNS_inflammation0.60806409
86MP0002420_abnormal_adaptive_immunity0.60092610
87MP0005452_abnormal_adipose_tissue0.59640106
88MP0002723_abnormal_immune_serum0.58465052
89MP0002078_abnormal_glucose_homeostasis0.57796258
90MP0001819_abnormal_immune_cell0.57285772
91MP0002419_abnormal_innate_immunity0.56989370
92MP0005332_abnormal_amino_acid0.56795316
93MP0003953_abnormal_hormone_level0.55605928
94MP0005000_abnormal_immune_tolerance0.54943351
95MP0002277_abnormal_respiratory_mucosa0.54918022
96MP0001501_abnormal_sleep_pattern0.53770336
97MP0002734_abnormal_mechanical_nocicepti0.53386805
98MP0001845_abnormal_inflammatory_respons0.52909461
99MP0001765_abnormal_ion_homeostasis0.52519662
100MP0004133_heterotaxia0.51916320

Predicted human phenotypes

RankGene SetZ-score
1Absent rod-and cone-mediated responses on ERG (HP:0007688)9.23280958
2Abnormal ciliary motility (HP:0012262)9.08304918
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.81371879
4Abnormal respiratory epithelium morphology (HP:0012253)8.17456918
5Abnormal respiratory motile cilium morphology (HP:0005938)8.17456918
6Abnormal respiratory motile cilium physiology (HP:0012261)7.94076937
7Chronic hepatic failure (HP:0100626)6.19590749
8Tubulointerstitial nephritis (HP:0001970)5.95080974
9Chronic bronchitis (HP:0004469)5.92483949
10Abnormal rod and cone electroretinograms (HP:0008323)5.58453445
11Rhinitis (HP:0012384)5.48978038
12Bronchiectasis (HP:0002110)4.87856155
13Nasal polyposis (HP:0100582)4.73764838
14Bronchitis (HP:0012387)4.56026790
15Constricted visual fields (HP:0001133)4.01382598
16Bony spicule pigmentary retinopathy (HP:0007737)3.89547642
17Abnormality of the nasal mucosa (HP:0000433)3.87076692
18Abnormality of the fingertips (HP:0001211)3.78898627
19Recurrent bronchitis (HP:0002837)3.62212493
20Abnormal hair whorl (HP:0010721)3.58123909
21Menstrual irregularities (HP:0000858)3.52494062
22Recurrent sinusitis (HP:0011108)3.49741948
23Cone-rod dystrophy (HP:0000548)3.46351098
24Recurrent otitis media (HP:0000403)3.18809761
25Hypoalphalipoproteinemia (HP:0003233)3.12885316
26Progressive sensorineural hearing impairment (HP:0000408)2.96264161
27Renovascular hypertension (HP:0100817)2.85691792
28Chronic sinusitis (HP:0011109)2.70183324
29Hyperactive renin-angiotensin system (HP:0000841)2.64952072
30Macroorchidism (HP:0000053)2.63962068
31Decreased circulating renin level (HP:0003351)2.63884306
32Tubulointerstitial abnormality (HP:0001969)2.60865460
33Insulin-resistant diabetes mellitus (HP:0000831)2.59652179
34Aortic aneurysm (HP:0004942)2.33781962
35Long nose (HP:0003189)2.25903524
36Anteriorly placed anus (HP:0001545)2.25398660
37Premature skin wrinkling (HP:0100678)2.25006323
38Gingivitis (HP:0000230)2.18064061
39Heterotopia (HP:0002282)2.18007638
40Infertility (HP:0000789)2.10920197
41Hyperkalemia (HP:0002153)2.08038552
42Increased purine levels (HP:0004368)2.04759219
43Hyperuricemia (HP:0002149)2.04759219
44Truncal obesity (HP:0001956)2.02850583
45Dynein arm defect of respiratory motile cilia (HP:0012255)13.3258042
46Absent/shortened dynein arms (HP:0200106)13.3258042
47Partial agenesis of the corpus callosum (HP:0001338)1.96499621
48Portal hypertension (HP:0001409)1.94695803
49Nephronophthisis (HP:0000090)1.89591296
50Recurrent pneumonia (HP:0006532)1.88055267
51Deep philtrum (HP:0002002)1.83612314
52Anal stenosis (HP:0002025)1.83065064
53Abnormality of the renal medulla (HP:0100957)1.82900762
54Subcapsular cataract (HP:0000523)1.77721184
55Abnormality of the hepatic vasculature (HP:0006707)1.76218468
56Progressive hearing impairment (HP:0001730)1.70139147
57Obsessive-compulsive behavior (HP:0000722)1.67517176
58Hepatitis (HP:0012115)1.63173928
59Hypolipoproteinemia (HP:0010981)1.61218400
60Abnormal social behavior (HP:0012433)1.59674991
61Impaired social interactions (HP:0000735)1.59674991
62Narrow palate (HP:0000189)1.59187752
63Growth hormone deficiency (HP:0000824)1.57542042
64Narrow nasal bridge (HP:0000446)1.57190570
65Renal salt wasting (HP:0000127)1.55043882
66Medial flaring of the eyebrow (HP:0010747)1.54108656
67Neoplasm of the heart (HP:0100544)1.52308157
68Abnormality of midbrain morphology (HP:0002418)1.51552774
69Molar tooth sign on MRI (HP:0002419)1.51552774
70Congenital primary aphakia (HP:0007707)1.47318029
71Nephritis (HP:0000123)1.47241846
72Hyperaldosteronism (HP:0000859)1.45491420
73Gait imbalance (HP:0002141)1.44474722
74Abnormality of the astrocytes (HP:0100707)1.42558583
75Astrocytoma (HP:0009592)1.42558583
76Poor coordination (HP:0002370)1.39739119
77Abnormality of chloride homeostasis (HP:0011422)1.39294630
78Abnormality of renin-angiotensin system (HP:0000847)1.39214359
79Supernumerary spleens (HP:0009799)1.38165051
80Delayed closure of the anterior fontanelle (HP:0001476)1.37690550
81Hypergonadotropic hypogonadism (HP:0000815)1.37181844
82Nephrogenic diabetes insipidus (HP:0009806)1.36108970
83Hypokalemic alkalosis (HP:0001949)1.34766400
84Nephrocalcinosis (HP:0000121)1.34534224
85Abnormality of the nasal septum (HP:0000419)1.32749346
86High pitched voice (HP:0001620)1.32473261
87Prominent nose (HP:0000448)1.31564203
88Retinitis pigmentosa (HP:0000510)1.30397181
89Broad hallux (HP:0010055)1.29895567
90Protruding tongue (HP:0010808)1.27476909
91Open mouth (HP:0000194)1.27299377
92Large for gestational age (HP:0001520)1.22008795
93Recurrent lower respiratory tract infections (HP:0002783)1.20189846
94Asthma (HP:0002099)1.19565897
95Abnormality of purine metabolism (HP:0004352)1.19442717
96Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.18018706
97Occipital encephalocele (HP:0002085)1.15597470
98Bell-shaped thorax (HP:0001591)1.14087982
99Atelectasis (HP:0100750)1.12495372
100Type II diabetes mellitus (HP:0005978)1.10725476

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.97853896
2MAPK153.52668790
3TYK23.52144090
4STK163.42691745
5FRK2.90804327
6MST42.69975278
7IRAK12.58274686
8BCR2.41366657
9ERBB22.39644618
10SGK22.34126569
11MAP3K22.19396243
12BLK2.18093383
13CAMK1D2.02219111
14CAMK1G1.97817465
15MST1R1.90208458
16MARK21.68192586
17MAP3K71.62524367
18SGK4941.61532570
19SGK2231.61532570
20BRD41.53321312
21ERN11.50253836
22ZAP701.49463363
23WNK11.48644275
24SGK31.48239899
25IRAK21.42835563
26IKBKE1.31010305
27IRAK41.28799743
28LATS11.22154659
29STK111.21586704
30CDC42BPA1.18903546
31CSNK1A1L1.16162222
32MUSK1.13902366
33MAP3K41.12049181
34RPS6KA21.09763730
35JAK11.06074905
36INSRR1.04884778
37TAOK11.03837597
38CHUK1.02452328
39MAP3K61.00673429
40MET0.99211279
41EGFR0.96688220
42CSK0.95172518
43AKT30.93534742
44IKBKB0.91991814
45WNK30.90243889
46RPS6KA60.84925702
47DAPK20.84037152
48BMPR1B0.80303861
49WNK40.79878691
50TRPM70.79721842
51MAP3K30.75942292
52CAMK40.72375900
53RPS6KC10.69552273
54RPS6KL10.69552273
55JAK20.67217727
56PTK60.67030165
57SGK10.66379565
58NME10.65086258
59STK100.64986618
60FYN0.64922770
61OXSR10.62316955
62PAK30.58635040
63ACVR1B0.56570434
64MAPK70.53534774
65LMTK20.53191958
66MAPKAPK20.48757014
67STK380.47577903
68PNCK0.47168538
69TGFBR10.46354644
70HCK0.45504309
71TEC0.44762267
72KSR20.44193827
73PIK3CA0.42310149
74PRKAA20.41070350
75MAPK30.40412041
76HIPK20.40198003
77MKNK20.39596850
78CDK60.38672651
79TAOK30.38355424
80MAPK10.38215859
81STK40.37858912
82PDGFRB0.37824311
83MAP2K70.37594193
84CDK80.36262776
85FER0.35476661
86SYK0.34985038
87STK30.34088416
88BTK0.32977897
89PTK2B0.31666521
90PRKCQ0.31190609
91PIM10.30663541
92MAP3K50.28527765
93GRK10.28466855
94STK390.27291073
95ATM0.26121726
96PRKCH0.25530327
97ABL10.25395579
98RET0.24247536
99PRKCZ0.23745803
100MTOR0.23661626

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.45793890
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.77364414
3ABC transporters_Homo sapiens_hsa020102.48596970
4Pancreatic secretion_Homo sapiens_hsa049722.11743900
5Pentose and glucuronate interconversions_Homo sapiens_hsa000402.05763008
6Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.01248901
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.92901664
8Linoleic acid metabolism_Homo sapiens_hsa005911.91786619
9Dorso-ventral axis formation_Homo sapiens_hsa043201.72233692
10Steroid hormone biosynthesis_Homo sapiens_hsa001401.68275198
11Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.56315350
12Notch signaling pathway_Homo sapiens_hsa043301.54509153
13Retinol metabolism_Homo sapiens_hsa008301.52207581
14Hematopoietic cell lineage_Homo sapiens_hsa046401.47393089
15Chemical carcinogenesis_Homo sapiens_hsa052041.45830142
16Jak-STAT signaling pathway_Homo sapiens_hsa046301.45814987
17Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.43969238
18Lysine degradation_Homo sapiens_hsa003101.41897269
19Transcriptional misregulation in cancer_Homo sapiens_hsa052021.40372086
20Circadian rhythm_Homo sapiens_hsa047101.39378138
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.36005024
22Huntingtons disease_Homo sapiens_hsa050161.33527545
23ErbB signaling pathway_Homo sapiens_hsa040121.31543656
24Sphingolipid metabolism_Homo sapiens_hsa006001.27549778
25Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.16925729
26Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.12895655
27Adherens junction_Homo sapiens_hsa045201.12444913
28Taste transduction_Homo sapiens_hsa047421.10336528
29Histidine metabolism_Homo sapiens_hsa003401.09385734
30Staphylococcus aureus infection_Homo sapiens_hsa051501.08050086
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.02478258
32Prolactin signaling pathway_Homo sapiens_hsa049171.01882652
33Complement and coagulation cascades_Homo sapiens_hsa046101.01799118
34Vitamin digestion and absorption_Homo sapiens_hsa049771.00972985
35Fat digestion and absorption_Homo sapiens_hsa049751.00450426
36TNF signaling pathway_Homo sapiens_hsa046680.98817380
37Inositol phosphate metabolism_Homo sapiens_hsa005620.96347151
38Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95226934
39Nicotine addiction_Homo sapiens_hsa050330.94563570
40Tryptophan metabolism_Homo sapiens_hsa003800.94430759
41Protein digestion and absorption_Homo sapiens_hsa049740.93447948
42Thyroid hormone signaling pathway_Homo sapiens_hsa049190.92512837
43Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.90779289
44Chronic myeloid leukemia_Homo sapiens_hsa052200.89268808
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.86897350
46Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.85926061
47B cell receptor signaling pathway_Homo sapiens_hsa046620.82773957
48Tuberculosis_Homo sapiens_hsa051520.82508632
49NOD-like receptor signaling pathway_Homo sapiens_hsa046210.82007324
50Starch and sucrose metabolism_Homo sapiens_hsa005000.80673291
51Influenza A_Homo sapiens_hsa051640.78895909
52Acute myeloid leukemia_Homo sapiens_hsa052210.78712342
53Hepatitis C_Homo sapiens_hsa051600.76902445
54Arachidonic acid metabolism_Homo sapiens_hsa005900.74586534
55Osteoclast differentiation_Homo sapiens_hsa043800.71655186
56Toxoplasmosis_Homo sapiens_hsa051450.69950848
57Viral myocarditis_Homo sapiens_hsa054160.69176741
58Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69017383
59Asthma_Homo sapiens_hsa053100.68864794
60Colorectal cancer_Homo sapiens_hsa052100.64658663
61Leishmaniasis_Homo sapiens_hsa051400.63842391
62Sphingolipid signaling pathway_Homo sapiens_hsa040710.60928185
63Glycosaminoglycan degradation_Homo sapiens_hsa005310.58586109
64Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.55913087
65Serotonergic synapse_Homo sapiens_hsa047260.55739940
66T cell receptor signaling pathway_Homo sapiens_hsa046600.55203741
67Amoebiasis_Homo sapiens_hsa051460.54651212
68Graft-versus-host disease_Homo sapiens_hsa053320.53790256
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53346269
70NF-kappa B signaling pathway_Homo sapiens_hsa040640.53262270
71Autoimmune thyroid disease_Homo sapiens_hsa053200.51777584
72Regulation of autophagy_Homo sapiens_hsa041400.51487385
73Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50469457
74FoxO signaling pathway_Homo sapiens_hsa040680.50328594
75AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.49758400
76Allograft rejection_Homo sapiens_hsa053300.49668788
77Prostate cancer_Homo sapiens_hsa052150.49609754
78Drug metabolism - other enzymes_Homo sapiens_hsa009830.49284140
79Chemokine signaling pathway_Homo sapiens_hsa040620.48846171
80Antigen processing and presentation_Homo sapiens_hsa046120.47828900
81Maturity onset diabetes of the young_Homo sapiens_hsa049500.46210078
82Small cell lung cancer_Homo sapiens_hsa052220.45494686
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44577586
84MAPK signaling pathway_Homo sapiens_hsa040100.43769622
85Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.43126827
86Nitrogen metabolism_Homo sapiens_hsa009100.42918226
87Glutamatergic synapse_Homo sapiens_hsa047240.42866897
88Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.42787837
89Toll-like receptor signaling pathway_Homo sapiens_hsa046200.42783475
90Non-small cell lung cancer_Homo sapiens_hsa052230.42432157
91Endometrial cancer_Homo sapiens_hsa052130.42336828
92Choline metabolism in cancer_Homo sapiens_hsa052310.41831128
93Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.41701431
94Calcium signaling pathway_Homo sapiens_hsa040200.41477145
95RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.41238985
96Herpes simplex infection_Homo sapiens_hsa051680.40443639
97Glycerolipid metabolism_Homo sapiens_hsa005610.40110409
98mTOR signaling pathway_Homo sapiens_hsa041500.40078493
99Ether lipid metabolism_Homo sapiens_hsa005650.39695432
100cAMP signaling pathway_Homo sapiens_hsa040240.39682540

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