NANOGP5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1interferon-gamma production (GO:0032609)9.33805900
2negative regulation of T cell mediated immunity (GO:0002710)7.67456566
3positive regulation of T cell chemotaxis (GO:0010820)7.34571396
4regulation of T cell chemotaxis (GO:0010819)7.34571396
5negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)7.31185673
6positive regulation of T cell cytokine production (GO:0002726)7.30724057
7positive regulation of T-helper 1 type immune response (GO:0002827)6.28606030
8negative regulation of interleukin-2 production (GO:0032703)5.83235608
9positive regulation of T cell mediated cytotoxicity (GO:0001916)5.77511752
10regulation of T cell mediated cytotoxicity (GO:0001914)5.71282122
11lymphocyte chemotaxis (GO:0048247)5.22981416
12positive regulation of type 2 immune response (GO:0002830)5.02202106
13positive regulation of alpha-beta T cell proliferation (GO:0046641)4.92183561
14positive regulation of transforming growth factor beta production (GO:0071636)4.71598026
15regulation of T-helper 1 type immune response (GO:0002825)4.68596117
16regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.52308213
17positive regulation of neutrophil chemotaxis (GO:0090023)4.45040572
18positive regulation of neutrophil migration (GO:1902624)4.45040572
19regulation of T cell cytokine production (GO:0002724)4.42168082
20activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO4.42072724
21regulation of lymphocyte chemotaxis (GO:1901623)4.33320634
22negative regulation of cytokine production involved in immune response (GO:0002719)4.14839096
23negative regulation of adaptive immune response (GO:0002820)4.10916804
24protein K6-linked ubiquitination (GO:0085020)4.04975071
25receptor guanylyl cyclase signaling pathway (GO:0007168)4.03064702
26positive regulation of granulocyte chemotaxis (GO:0071624)3.90498201
27positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.90459296
28sleep (GO:0030431)3.87221582
29negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.82766930
30negative regulation of lymphocyte mediated immunity (GO:0002707)3.78992016
31regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.72100499
32phosphorelay signal transduction system (GO:0000160)3.71271658
33male meiosis (GO:0007140)3.70970914
34histone H3-K4 trimethylation (GO:0080182)3.66880724
35negative regulation of alpha-beta T cell activation (GO:0046636)3.66306811
36regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.65890269
37cellular response to interleukin-4 (GO:0071353)3.63967929
38positive regulation of immunoglobulin production (GO:0002639)3.62729603
39positive regulation of T cell migration (GO:2000406)3.61437747
40positive regulation of gamma-delta T cell activation (GO:0046645)3.61102443
41proline transport (GO:0015824)3.57098319
42lymphocyte migration (GO:0072676)3.55898063
43regulation of T cell migration (GO:2000404)3.52782792
44negative regulation of production of molecular mediator of immune response (GO:0002701)3.51209353
45methionine biosynthetic process (GO:0009086)3.50975830
46positive regulation of T cell mediated immunity (GO:0002711)3.46618280
47negative regulation of viral transcription (GO:0032897)3.45891565
48regulation of alpha-beta T cell proliferation (GO:0046640)3.45516166
49interleukin-6-mediated signaling pathway (GO:0070102)3.38964815
50positive regulation of release of sequestered calcium ion into cytosol (GO:0051281)3.37749132
51regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.35500647
52regulation of neutrophil migration (GO:1902622)3.34518872
53regulation of neutrophil chemotaxis (GO:0090022)3.34518872
54positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.32255275
55cellular response to ethanol (GO:0071361)3.32007793
56positive regulation of defense response to virus by host (GO:0002230)3.31695899
57leukotriene biosynthetic process (GO:0019370)3.31498367
58aspartate family amino acid biosynthetic process (GO:0009067)3.25536876
59negative regulation of execution phase of apoptosis (GO:1900118)3.24193152
60regulation of leukocyte mediated cytotoxicity (GO:0001910)3.23058497
61interferon-gamma secretion (GO:0072643)3.22032644
62regulation of rhodopsin mediated signaling pathway (GO:0022400)3.21689214
63regulation of nuclear cell cycle DNA replication (GO:0033262)3.19784047
64lipopolysaccharide biosynthetic process (GO:0009103)3.19513526
65positive regulation of cell killing (GO:0031343)3.17672111
66positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.14819443
67autophagic vacuole fusion (GO:0000046)3.14251113
68hepatocyte apoptotic process (GO:0097284)3.11465175
69regulation of cell killing (GO:0031341)3.09505493
70mannosylation (GO:0097502)3.09314511
71pyrimidine-containing compound transmembrane transport (GO:0072531)3.08312168
72glucosamine-containing compound catabolic process (GO:1901072)3.08073522
73lipopolysaccharide metabolic process (GO:0008653)3.04954357
74coenzyme A metabolic process (GO:0015936)3.04557798
75negative regulation of glucose transport (GO:0010829)3.02169646
76regulation of gamma-delta T cell differentiation (GO:0045586)3.01999803
77regulation of T cell mediated immunity (GO:0002709)3.00669649
78ribonucleoprotein complex disassembly (GO:0032988)3.00352899
79metallo-sulfur cluster assembly (GO:0031163)2.93068621
80iron-sulfur cluster assembly (GO:0016226)2.93068621
81response to interleukin-4 (GO:0070670)2.92902538
82positive regulation of lymphocyte migration (GO:2000403)2.92703379
83cGMP metabolic process (GO:0046068)2.92596188
84methionine metabolic process (GO:0006555)2.89608804
85rhodopsin mediated signaling pathway (GO:0016056)2.87825957
86piRNA metabolic process (GO:0034587)2.86637902
87positive regulation of granulocyte differentiation (GO:0030854)2.86160691
88mitochondrial genome maintenance (GO:0000002)2.85488704
89regulation of B cell receptor signaling pathway (GO:0050855)2.82778020
90negative regulation of leukocyte mediated immunity (GO:0002704)2.80302090
91positive regulation of B cell mediated immunity (GO:0002714)2.79540841
92positive regulation of immunoglobulin mediated immune response (GO:0002891)2.79540841
93negative regulation of glucose import (GO:0046325)2.78893342
94natural killer cell differentiation (GO:0001779)2.78433551
95glomerular basement membrane development (GO:0032836)2.74070067
96DNA deamination (GO:0045006)2.73815878
97positive thymic T cell selection (GO:0045059)2.73746738
98regulation of gamma-delta T cell activation (GO:0046643)2.72094587
99regulation of glucokinase activity (GO:0033131)2.71021576
100regulation of hexokinase activity (GO:1903299)2.71021576

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.55443613
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.29870918
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.90817349
4RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.90083704
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.33855239
6ZNF274_21170338_ChIP-Seq_K562_Hela3.28234817
7VDR_22108803_ChIP-Seq_LS180_Human3.02125642
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.97352252
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.60230673
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.54109919
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.53959429
12AR_21572438_ChIP-Seq_LNCaP_Human2.51334754
13PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.39397340
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.31932309
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.14638816
16PCGF2_27294783_Chip-Seq_NPCs_Mouse1.97686251
17PCGF2_27294783_Chip-Seq_ESCs_Mouse1.84131177
18IRF1_19129219_ChIP-ChIP_H3396_Human1.83858429
19MYB_26560356_Chip-Seq_TH2_Human1.81265230
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.80275338
21GATA1_22025678_ChIP-Seq_K562_Human1.79009997
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.78457057
23POU3F2_20337985_ChIP-ChIP_501MEL_Human1.78055441
24ZFP57_27257070_Chip-Seq_ESCs_Mouse1.68304619
25GATA3_26560356_Chip-Seq_TH2_Human1.66304200
26ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.57268816
27ER_23166858_ChIP-Seq_MCF-7_Human1.53105259
28NFE2_27457419_Chip-Seq_LIVER_Mouse1.52523351
29SUZ12_27294783_Chip-Seq_NPCs_Mouse1.49276163
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.48532573
31FUS_26573619_Chip-Seq_HEK293_Human1.40051544
32SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.39457743
33TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.38316060
34VDR_23849224_ChIP-Seq_CD4+_Human1.37097889
35IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.36624781
36CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.36458443
37NOTCH1_21737748_ChIP-Seq_TLL_Human1.34757451
38MYC_18940864_ChIP-ChIP_HL60_Human1.30706524
39GATA3_27048872_Chip-Seq_THYMUS_Human1.30581715
40CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.30580739
41EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.30414217
42EGR1_23403033_ChIP-Seq_LIVER_Mouse1.27115435
43PADI4_21655091_ChIP-ChIP_MCF-7_Human1.26693852
44EZH2_27294783_Chip-Seq_NPCs_Mouse1.26406351
45HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.26333307
46ETS1_20019798_ChIP-Seq_JURKAT_Human1.26248961
47POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19527645
48TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19527645
49SCL_19346495_ChIP-Seq_HPC-7_Human1.19219964
50CRX_20693478_ChIP-Seq_RETINA_Mouse1.18847357
51P53_22387025_ChIP-Seq_ESCs_Mouse1.17067268
52EWS_26573619_Chip-Seq_HEK293_Human1.15560911
53MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.15279216
54SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.14509711
55GATA3_26560356_Chip-Seq_TH1_Human1.14171526
56ELF1_17652178_ChIP-ChIP_JURKAT_Human1.13092244
57PRDM14_20953172_ChIP-Seq_ESCs_Human1.12799121
58STAT3_23295773_ChIP-Seq_U87_Human1.12226975
59IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.11561492
60CBP_20019798_ChIP-Seq_JUKART_Human1.11561492
61HOXB7_26014856_ChIP-Seq_BT474_Human1.10596384
62NANOG_18555785_Chip-Seq_ESCs_Mouse1.10432638
63CBX2_22325352_ChIP-Seq_293T-Rex_Human1.09881275
64OCT4_21477851_ChIP-Seq_ESCs_Mouse1.08898418
65TCF4_23295773_ChIP-Seq_U87_Human1.06863551
66OCT4_18555785_Chip-Seq_ESCs_Mouse1.05688667
67LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.05478360
68JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.04406408
69EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.04029322
70PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.02609181
71NCOR_22424771_ChIP-Seq_293T_Human1.02501118
72EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01935887
73BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01046706
74SUZ12_18555785_Chip-Seq_ESCs_Mouse1.00897351
75MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00873557
76P300_18555785_Chip-Seq_ESCs_Mouse1.00099151
77RUNX_20019798_ChIP-Seq_JUKART_Human0.99372938
78FLI1_21867929_ChIP-Seq_TH2_Mouse0.99370386
79AR_20517297_ChIP-Seq_VCAP_Human0.99112984
80STAT3_18555785_Chip-Seq_ESCs_Mouse0.98455671
81NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.97143062
82ETV1_20927104_ChIP-Seq_GIST48_Human0.96671399
83CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.96562211
84PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96175840
85ELK1_19687146_ChIP-ChIP_HELA_Human0.94924003
86UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94663236
87NMYC_18555785_Chip-Seq_ESCs_Mouse0.93972801
88GATA3_21878914_ChIP-Seq_MCF-7_Human0.92703562
89LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.92577354
90PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.92374397
91RUNX1_27457419_Chip-Seq_LIVER_Mouse0.92372289
92FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.92212394
93IGF1R_20145208_ChIP-Seq_DFB_Human0.91322113
94PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.90519929
95AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90168539
96RBPJ_21746931_ChIP-Seq_IB4_Human0.89224578
97SMAD4_21799915_ChIP-Seq_A2780_Human0.88426947
98EST1_17652178_ChIP-ChIP_JURKAT_Human0.87852139
99MYB_26560356_Chip-Seq_TH1_Human0.87816734
100CTCF_18555785_Chip-Seq_ESCs_Mouse0.87750725

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005310_abnormal_salivary_gland4.35055212
2MP0008877_abnormal_DNA_methylation4.24342560
3MP0000569_abnormal_digit_pigmentation3.70768729
4MP0003195_calcinosis3.41426282
5MP0002876_abnormal_thyroid_physiology3.28601128
6MP0003646_muscle_fatigue3.19563806
7MP0002006_tumorigenesis2.77360836
8MP0005671_abnormal_response_to2.66702236
9MP0002653_abnormal_ependyma_morphology2.48965217
10MP0000015_abnormal_ear_pigmentation2.31605950
11MP0009840_abnormal_foam_cell2.30819059
12MP0003656_abnormal_erythrocyte_physiolo2.24119746
13MP0003011_delayed_dark_adaptation2.18557210
14MP0000613_abnormal_salivary_gland2.02928442
15MP0002102_abnormal_ear_morphology1.95201793
16MP0005551_abnormal_eye_electrophysiolog1.90087042
17MP0003191_abnormal_cellular_cholesterol1.89812686
18MP0003763_abnormal_thymus_physiology1.87606877
19MP0005075_abnormal_melanosome_morpholog1.86192301
20MP0003045_fibrosis1.75518817
21MP0002396_abnormal_hematopoietic_system1.68944927
22MP0003786_premature_aging1.67390235
23MP0009333_abnormal_splenocyte_physiolog1.65516484
24MP0001800_abnormal_humoral_immune1.64594581
25MP0005000_abnormal_immune_tolerance1.64442071
26MP0004808_abnormal_hematopoietic_stem1.58177922
27MP0002723_abnormal_immune_serum1.52362585
28MP0004130_abnormal_muscle_cell1.49833359
29MP0005174_abnormal_tail_pigmentation1.47128305
30MP0001501_abnormal_sleep_pattern1.45621265
31MP0000013_abnormal_adipose_tissue1.43429537
32MP0003303_peritoneal_inflammation1.41650005
33MP0010386_abnormal_urinary_bladder1.37086449
34MP0002254_reproductive_system_inflammat1.36281159
35MP0003329_amyloid_beta_deposits1.33457920
36MP0002452_abnormal_antigen_presenting1.32061114
37MP0009046_muscle_twitch1.31485272
38MP0001270_distended_abdomen1.28879259
39MP0001819_abnormal_immune_cell1.28772532
40MP0002420_abnormal_adaptive_immunity1.27098419
41MP0004145_abnormal_muscle_electrophysio1.25353897
42MP0010368_abnormal_lymphatic_system1.24402677
43MP0002398_abnormal_bone_marrow1.24059008
44MP0002148_abnormal_hypersensitivity_rea1.23554725
45MP0002168_other_aberrant_phenotype1.20077892
46MP0002722_abnormal_immune_system1.15151047
47MP0005253_abnormal_eye_physiology1.14596180
48MP0005647_abnormal_sex_gland1.12949472
49MP0004036_abnormal_muscle_relaxation1.08734457
50MP0000689_abnormal_spleen_morphology1.08382991
51MP0000604_amyloidosis1.06070162
52MP0005025_abnormal_response_to1.04207630
53MP0004084_abnormal_cardiac_muscle1.02849752
54MP0004134_abnormal_chest_morphology1.02441382
55MP0008872_abnormal_physiological_respon1.01820634
56MP0004142_abnormal_muscle_tone1.00622858
57MP0000716_abnormal_immune_system0.99774943
58MP0001661_extended_life_span0.97724539
59MP0005360_urolithiasis0.97551669
60MP0003172_abnormal_lysosome_physiology0.97078803
61MP0002419_abnormal_innate_immunity0.96623424
62MP0003724_increased_susceptibility_to0.96608347
63MP0005395_other_phenotype0.95344212
64MP0004233_abnormal_muscle_weight0.93688550
65MP0006035_abnormal_mitochondrial_morpho0.93222795
66MP0003718_maternal_effect0.92675236
67MP0003950_abnormal_plasma_membrane0.91652850
68MP0010329_abnormal_lipoprotein_level0.90983633
69MP0000427_abnormal_hair_cycle0.90919220
70MP0002229_neurodegeneration0.90735752
71MP0003866_abnormal_defecation0.90330593
72MP0009785_altered_susceptibility_to0.89852707
73MP0010094_abnormal_chromosome_stability0.89837566
74MP0004043_abnormal_pH_regulation0.87361866
75MP0001845_abnormal_inflammatory_respons0.86927447
76MP0000703_abnormal_thymus_morphology0.84940346
77MP0001529_abnormal_vocalization0.83935155
78MP0002136_abnormal_kidney_physiology0.82133809
79MP0002429_abnormal_blood_cell0.81508152
80MP0004185_abnormal_adipocyte_glucose0.73232483
81MP0003943_abnormal_hepatobiliary_system0.72128019
82MP0005167_abnormal_blood-brain_barrier0.71553599
83MP0008995_early_reproductive_senescence0.69503435
84MP0003959_abnormal_lean_body0.69492335
85MP0008775_abnormal_heart_ventricle0.69423401
86MP0004924_abnormal_behavior0.68759524
87MP0005386_behavior/neurological_phenoty0.68759524
88MP0005332_abnormal_amino_acid0.66495809
89MP0001764_abnormal_homeostasis0.65339879
90MP0004484_altered_response_of0.64998579
91MP0003448_altered_tumor_morphology0.63812558
92MP0002019_abnormal_tumor_incidence0.63780235
93MP0001545_abnormal_hematopoietic_system0.62538071
94MP0005397_hematopoietic_system_phenotyp0.62538071
95MP0009745_abnormal_behavioral_response0.62129745
96MP0005058_abnormal_lysosome_morphology0.62020992
97MP0001664_abnormal_digestion0.62005958
98MP0009703_decreased_birth_body0.61415040
99MP0009643_abnormal_urine_homeostasis0.59723515
100MP0008469_abnormal_protein_level0.59364347

Predicted human phenotypes

RankGene SetZ-score
1Retrobulbar optic neuritis (HP:0100654)7.55073218
2Optic neuritis (HP:0100653)7.55073218
3Orchitis (HP:0100796)6.74948222
4Myositis (HP:0100614)5.64803679
5Decreased central vision (HP:0007663)5.27885618
6Keratoconjunctivitis (HP:0001096)5.12104954
7Keratoconjunctivitis sicca (HP:0001097)5.05643627
8Decreased electroretinogram (ERG) amplitude (HP:0000654)4.84906113
9Increased corneal curvature (HP:0100692)4.35606094
10Keratoconus (HP:0000563)4.35606094
11Arterial thrombosis (HP:0004420)4.14768081
12Nonimmune hydrops fetalis (HP:0001790)3.89900662
13Beaking of vertebral bodies (HP:0004568)3.80401616
14Absent rod-and cone-mediated responses on ERG (HP:0007688)3.73315850
15Pulmonary infiltrates (HP:0002113)3.52619215
16Keratitis (HP:0000491)3.48168927
17Type I transferrin isoform profile (HP:0003642)3.47669009
18Microvesicular hepatic steatosis (HP:0001414)3.30723481
19Abnormality of the pericardium (HP:0001697)3.27540307
20Visual hallucinations (HP:0002367)3.21396532
21Abnormality of the labia minora (HP:0012880)3.09739552
22Hypoplastic ischia (HP:0003175)3.07697643
23Hemoptysis (HP:0002105)3.06525376
24Attenuation of retinal blood vessels (HP:0007843)3.05397799
25Focal motor seizures (HP:0011153)3.01206062
26J-shaped sella turcica (HP:0002680)2.99889069
27Abnormality of lateral ventricle (HP:0030047)2.87442887
28Gangrene (HP:0100758)2.82664799
29Hypoplasia of the pons (HP:0012110)2.82579888
30Anorexia (HP:0002039)2.82528394
31Abnormality of aspartate family amino acid metabolism (HP:0010899)2.81248586
32Encephalitis (HP:0002383)2.71356859
33Abnormal rod and cone electroretinograms (HP:0008323)2.70048604
34Polyneuropathy (HP:0001271)2.69689555
35Supranuclear gaze palsy (HP:0000605)2.69415594
36Congenital stationary night blindness (HP:0007642)2.68167488
37Abnormality of homocysteine metabolism (HP:0010919)2.65616149
38Homocystinuria (HP:0002156)2.65616149
39Abnormality of the pons (HP:0007361)2.65338933
40Abnormality of the ischium (HP:0003174)2.64034861
41Cone-rod dystrophy (HP:0000548)2.62677732
42Agammaglobulinemia (HP:0004432)2.60088442
43Abnormality of the pleura (HP:0002103)2.59800361
44Abnormal protein glycosylation (HP:0012346)2.58245979
45Abnormal glycosylation (HP:0012345)2.58245979
46Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.58245979
47Abnormal protein N-linked glycosylation (HP:0012347)2.58245979
48Abnormality of macular pigmentation (HP:0008002)2.57646908
49Type II lissencephaly (HP:0007260)2.54398521
50Acne (HP:0001061)2.51209026
51Abnormality of glycolipid metabolism (HP:0010969)2.49996414
52Abnormality of liposaccharide metabolism (HP:0010968)2.49996414
53Abnormality of glycosphingolipid metabolism (HP:0004343)2.49996414
54Menstrual irregularities (HP:0000858)2.46510517
55Horizontal nystagmus (HP:0000666)2.45180209
56Cerebellar dysplasia (HP:0007033)2.44338397
57Slow saccadic eye movements (HP:0000514)2.41838210
58Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.39131277
59Lipid accumulation in hepatocytes (HP:0006561)2.37408291
60Pulmonary embolism (HP:0002204)2.34092887
61Gastrointestinal infarctions (HP:0005244)2.30009648
62Abnormality of the aortic arch (HP:0012303)2.28379458
63Abnormal auditory evoked potentials (HP:0006958)2.25040219
64Mitral stenosis (HP:0001718)2.19410943
65IgG deficiency (HP:0004315)2.16832799
66Chronic mucocutaneous candidiasis (HP:0002728)2.13424909
67Recurrent cutaneous fungal infections (HP:0011370)2.13424909
68Recurrent corneal erosions (HP:0000495)2.10716879
69Cutaneous melanoma (HP:0012056)2.09555051
70Thrombophlebitis (HP:0004418)2.06264657
71Glomerulopathy (HP:0100820)2.01531635
72Abnormality of the pubic bones (HP:0003172)2.01474824
73Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.99906869
74Follicular hyperkeratosis (HP:0007502)1.99232225
75Vasculitis (HP:0002633)1.95489348
76Hyperglycinuria (HP:0003108)1.94819408
77Prominent nose (HP:0000448)1.92929244
78Agitation (HP:0000713)1.91170474
79Prostate neoplasm (HP:0100787)1.89659940
80Pancreatic fibrosis (HP:0100732)1.89252676
81Abnormality of the endocardium (HP:0004306)1.87103995
82Vertigo (HP:0002321)1.86310954
83Megaloblastic anemia (HP:0001889)1.84856824
84Neoplasm of the heart (HP:0100544)1.84372149
85Chest pain (HP:0100749)1.84188287
86Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.83637036
87Meningitis (HP:0001287)1.82734649
88Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.82274951
89Abnormality of the prostate (HP:0008775)1.80626244
90Abnormal delayed hypersensitivity skin test (HP:0002963)1.79401380
91Abnormality of serum amino acid levels (HP:0003112)1.76621132
92Fair hair (HP:0002286)1.74780941
93Cerebral hypomyelination (HP:0006808)1.71070856
94Metaphyseal dysplasia (HP:0100255)1.65817145
95Abnormality of the epiphyses of the hand (HP:0005924)1.63743524
96Pendular nystagmus (HP:0012043)1.63287387
97Abnormality of the lumbar spine (HP:0100712)1.62889246
98Central scotoma (HP:0000603)1.62812165
99Striae distensae (HP:0001065)1.61066238
100Abnormality of the vitamin B12 metabolism (HP:0004341)1.60742628

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK94.39739717
2TAOK34.32196614
3IRAK44.31886539
4CAMKK24.11118885
5BRSK23.73443631
6PKN23.63543750
7FES3.18509573
8FLT33.13997059
9TXK3.02567486
10TLK12.64412821
11MAP3K42.53868694
12PIK3CG2.40506178
13EPHA32.15059764
14ZAK2.06832028
15JAK31.91012045
16PINK11.76107290
17IRAK11.71581284
18CAMKK11.68820372
19MAP3K141.58904531
20WNK41.48420210
21ADRBK21.44693095
22ERN11.34757864
23TEC1.22845932
24AKT31.16254133
25DYRK1B1.13532064
26MET1.13284847
27WNK31.13122503
28TSSK61.08253127
29TRPM71.07893993
30FRK1.07339940
31BTK1.04992497
32BRSK11.02019377
33PAK21.00974856
34MATK1.00446193
35OXSR10.98839876
36MAPK110.98805716
37HCK0.98598629
38IKBKB0.97213724
39BCKDK0.97070827
40MAP3K130.89901764
41IKBKE0.87623890
42SYK0.84710987
43PRKCQ0.84610482
44TYK20.80800778
45PRKAA20.74837919
46MELK0.68229150
47NTRK30.67678875
48STK38L0.67496201
49ABL10.66591763
50MAP2K60.63922911
51ITK0.63076212
52IRAK20.62303303
53GRK10.62117948
54STK390.60661563
55MAPKAPK50.59964972
56CSK0.59446170
57SRPK10.57129859
58IGF1R0.54581137
59ATR0.53627832
60LCK0.53313829
61ACVR1B0.51498078
62EIF2AK20.51089047
63FER0.48339535
64MAPK70.47362673
65ADRBK10.47188169
66TBK10.46684886
67PHKG10.46275593
68PHKG20.46275593
69MINK10.45427503
70MAP2K30.45289093
71DAPK10.45050112
72KIT0.43012462
73LYN0.42939317
74PBK0.42358512
75OBSCN0.42342510
76MAPK30.40277660
77JAK20.38634674
78RPS6KB20.38569219
79MAP2K20.36435983
80MAPKAPK30.35235518
81EPHB10.33402313
82DYRK1A0.31036785
83WNK10.30446158
84MAP3K70.29644573
85CHEK10.29221902
86BMPR1B0.25841093
87STK110.25567191
88PRKAA10.24751353
89CHUK0.24413626
90MAPK10.23557348
91TAF10.22313255
92ERBB30.21951963
93NUAK10.21798337
94CDK40.19260438
95PIM20.18832208
96MAPK130.17612663
97MAPK80.17542006
98JAK10.17479432
99NME10.16454742
100EIF2AK30.16408741

Predicted pathways (KEGG)

RankGene SetZ-score
1One carbon pool by folate_Homo sapiens_hsa006703.98086948
2Phototransduction_Homo sapiens_hsa047443.79757301
3Primary immunodeficiency_Homo sapiens_hsa053403.41638494
4Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.90815012
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.36374940
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.23622186
7SNARE interactions in vesicular transport_Homo sapiens_hsa041302.22656952
8Homologous recombination_Homo sapiens_hsa034402.17309209
9Olfactory transduction_Homo sapiens_hsa047402.10219298
10Cyanoamino acid metabolism_Homo sapiens_hsa004602.02210577
11Linoleic acid metabolism_Homo sapiens_hsa005911.94446086
12Jak-STAT signaling pathway_Homo sapiens_hsa046301.89951609
13Caffeine metabolism_Homo sapiens_hsa002321.86116875
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.82760397
15Ether lipid metabolism_Homo sapiens_hsa005651.79398693
16Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.76176486
17RNA polymerase_Homo sapiens_hsa030201.75430483
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.69505787
19Antigen processing and presentation_Homo sapiens_hsa046121.68230122
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.68032792
21Protein export_Homo sapiens_hsa030601.67954970
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.67260066
23Malaria_Homo sapiens_hsa051441.66807233
24Selenocompound metabolism_Homo sapiens_hsa004501.47643549
25Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.33312112
26Circadian rhythm_Homo sapiens_hsa047101.32419818
27Purine metabolism_Homo sapiens_hsa002301.27938622
28Other glycan degradation_Homo sapiens_hsa005111.24436413
29Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.22243740
30NOD-like receptor signaling pathway_Homo sapiens_hsa046211.20300507
31Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.18119942
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.18083915
33Glycosaminoglycan degradation_Homo sapiens_hsa005311.16291167
34Lysosome_Homo sapiens_hsa041421.14854328
35NF-kappa B signaling pathway_Homo sapiens_hsa040641.13740288
36Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.13678219
37Chemokine signaling pathway_Homo sapiens_hsa040621.11871424
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.11513508
39Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.06876310
40Basal transcription factors_Homo sapiens_hsa030221.05658629
41ABC transporters_Homo sapiens_hsa020101.05572921
42Fatty acid metabolism_Homo sapiens_hsa012121.04589019
43Tryptophan metabolism_Homo sapiens_hsa003800.99576285
44Fatty acid elongation_Homo sapiens_hsa000620.94417968
45Fanconi anemia pathway_Homo sapiens_hsa034600.92461288
46Butanoate metabolism_Homo sapiens_hsa006500.92216749
47Fatty acid degradation_Homo sapiens_hsa000710.89081459
48N-Glycan biosynthesis_Homo sapiens_hsa005100.88526189
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.88432603
50B cell receptor signaling pathway_Homo sapiens_hsa046620.87604120
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.84390522
52Pentose and glucuronate interconversions_Homo sapiens_hsa000400.76290174
53Glycerophospholipid metabolism_Homo sapiens_hsa005640.74626653
54Graft-versus-host disease_Homo sapiens_hsa053320.74018565
55Fat digestion and absorption_Homo sapiens_hsa049750.73862497
56Measles_Homo sapiens_hsa051620.72595173
57Asthma_Homo sapiens_hsa053100.72430930
58RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.72354659
59Nitrogen metabolism_Homo sapiens_hsa009100.70675679
60T cell receptor signaling pathway_Homo sapiens_hsa046600.69366922
61Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.68861617
62beta-Alanine metabolism_Homo sapiens_hsa004100.67460751
63Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.66185405
64Autoimmune thyroid disease_Homo sapiens_hsa053200.64202302
65Allograft rejection_Homo sapiens_hsa053300.63799077
66Morphine addiction_Homo sapiens_hsa050320.62571159
67Drug metabolism - other enzymes_Homo sapiens_hsa009830.62327052
68Leishmaniasis_Homo sapiens_hsa051400.61787306
69Sulfur metabolism_Homo sapiens_hsa009200.60003805
70Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.56646963
71RNA degradation_Homo sapiens_hsa030180.56538362
72Insulin resistance_Homo sapiens_hsa049310.55278541
73Legionellosis_Homo sapiens_hsa051340.51987262
74Non-homologous end-joining_Homo sapiens_hsa034500.49928485
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49800454
76Ovarian steroidogenesis_Homo sapiens_hsa049130.49754024
77Glycerolipid metabolism_Homo sapiens_hsa005610.46626470
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46190987
79Systemic lupus erythematosus_Homo sapiens_hsa053220.43837467
80Peroxisome_Homo sapiens_hsa041460.43636131
81Arachidonic acid metabolism_Homo sapiens_hsa005900.42462829
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.41982061
83Herpes simplex infection_Homo sapiens_hsa051680.41907894
84Type I diabetes mellitus_Homo sapiens_hsa049400.38365734
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.38307866
86Retinol metabolism_Homo sapiens_hsa008300.37754206
87Nucleotide excision repair_Homo sapiens_hsa034200.37135115
88Starch and sucrose metabolism_Homo sapiens_hsa005000.36376240
89Regulation of autophagy_Homo sapiens_hsa041400.35479367
90Toxoplasmosis_Homo sapiens_hsa051450.35261833
91Propanoate metabolism_Homo sapiens_hsa006400.34734306
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33013136
93mTOR signaling pathway_Homo sapiens_hsa041500.31992012
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.31866025
95Taste transduction_Homo sapiens_hsa047420.31088293
96Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.29300727
97TNF signaling pathway_Homo sapiens_hsa046680.28565964
98Viral myocarditis_Homo sapiens_hsa054160.26651146
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.26482463
100p53 signaling pathway_Homo sapiens_hsa041150.25970008

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