NANOS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a CCHC-type zinc finger protein that is a member of the nanos family. This protein co-localizes with the RNA-binding protein pumilio RNA-binding family member 2 and may be involved in regulating translation as a post-transcriptional repressor. Mutations in this gene are associated with spermatogenic impairment. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)6.68937805
2regulation of acrosome reaction (GO:0060046)6.31978327
3multicellular organism reproduction (GO:0032504)5.62894948
4regulation of DNA methylation (GO:0044030)5.38529551
5DNA methylation involved in gamete generation (GO:0043046)5.30522631
6behavioral response to nicotine (GO:0035095)5.23136611
7regulation of female gonad development (GO:2000194)5.13509105
8regulation of meiosis I (GO:0060631)5.06744901
9meiotic cell cycle (GO:0051321)4.79145931
10retinal cone cell development (GO:0046549)4.73494361
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.13754951
12female gamete generation (GO:0007292)4.11915189
13DNA deamination (GO:0045006)4.10495024
14postsynaptic membrane organization (GO:0001941)3.90526288
15oocyte development (GO:0048599)3.90275790
16facial nerve structural organization (GO:0021612)3.81819309
17respiratory chain complex IV assembly (GO:0008535)3.76921490
18positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.72609981
19detection of light stimulus involved in visual perception (GO:0050908)3.67382319
20detection of light stimulus involved in sensory perception (GO:0050962)3.67382319
21synapsis (GO:0007129)3.65700810
22gene silencing by RNA (GO:0031047)3.59745521
23cytochrome complex assembly (GO:0017004)3.54701733
24male meiosis I (GO:0007141)3.51928571
25glycine transport (GO:0015816)3.49458351
26neuron fate determination (GO:0048664)3.43982367
27reproduction (GO:0000003)3.38153158
28negative regulation of reproductive process (GO:2000242)3.37586506
29epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.36805354
30male meiosis (GO:0007140)3.36632611
31regulation of cell maturation (GO:1903429)3.35983875
32positive regulation of gastrulation (GO:2000543)3.33307996
33superoxide anion generation (GO:0042554)3.27388895
34positive regulation of histone H3-K4 methylation (GO:0051571)3.25606044
35presynaptic membrane assembly (GO:0097105)3.20517645
36regulation of action potential (GO:0098900)3.19551136
37centriole replication (GO:0007099)3.19189076
38regulation of calcium ion-dependent exocytosis (GO:0017158)3.13200680
39dopamine biosynthetic process (GO:0042416)3.08808727
40regulation of meiosis (GO:0040020)3.06945242
41somite rostral/caudal axis specification (GO:0032525)3.06074552
42positive regulation of meiosis (GO:0045836)3.05441013
43DNA replication checkpoint (GO:0000076)3.00522956
44response to interferon-beta (GO:0035456)2.94318910
45positive regulation of meiotic cell cycle (GO:0051446)2.89535366
46defense response to protozoan (GO:0042832)2.89050556
47telomere maintenance via semi-conservative replication (GO:0032201)2.88864080
48lymphoid progenitor cell differentiation (GO:0002320)2.88621397
49mannosylation (GO:0097502)2.87256492
50mast cell activation (GO:0045576)2.87253794
51platelet dense granule organization (GO:0060155)2.86912673
52immunoglobulin mediated immune response (GO:0016064)2.86802898
53deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.85601782
54regulation of steroid hormone secretion (GO:2000831)2.84398430
55epithelial cilium movement (GO:0003351)2.83889460
56intra-S DNA damage checkpoint (GO:0031573)2.76492423
57cellular response to ATP (GO:0071318)2.75102942
58inositol phosphate dephosphorylation (GO:0046855)2.73703271
59phosphorylated carbohydrate dephosphorylation (GO:0046838)2.73703271
60myeloid dendritic cell activation (GO:0001773)2.71026528
61telomere maintenance via recombination (GO:0000722)2.70298040
62cellular response to interferon-beta (GO:0035458)2.69744931
63positive regulation of macrophage differentiation (GO:0045651)2.69595309
64peristalsis (GO:0030432)2.68981234
65inositol phosphate catabolic process (GO:0071545)2.68324006
66regulation of meiotic cell cycle (GO:0051445)2.67867669
67endosome to pigment granule transport (GO:0043485)2.67854040
68endosome to melanosome transport (GO:0035646)2.67854040
69response to interferon-alpha (GO:0035455)2.67033368
70chromosome organization involved in meiosis (GO:0070192)2.66074500
71photoreceptor cell development (GO:0042461)2.65899159
72positive regulation of catecholamine secretion (GO:0033605)2.65364644
73negative regulation of cAMP-mediated signaling (GO:0043951)2.65343614
74regulation of skeletal muscle contraction (GO:0014819)2.64670359
75single fertilization (GO:0007338)2.64576662
76cellular response to exogenous dsRNA (GO:0071360)2.63986418
77cranial nerve structural organization (GO:0021604)2.63723857
78negative regulation of mast cell activation (GO:0033004)2.63288649
79fertilization (GO:0009566)2.62717430
80regulation of phospholipid biosynthetic process (GO:0071071)2.62494503
81meiosis I (GO:0007127)2.61387132
82response to peptidoglycan (GO:0032494)2.61235708
83positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.60386182
84positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.60386182
85positive regulation of mitotic sister chromatid separation (GO:1901970)2.60386182
86DNA methylation (GO:0006306)2.60164335
87DNA alkylation (GO:0006305)2.60164335
88protein K6-linked ubiquitination (GO:0085020)2.59792515
89eye photoreceptor cell development (GO:0042462)2.58687560
90tRNA methylation (GO:0030488)2.58438313
91presynaptic membrane organization (GO:0097090)2.57610151
92dendritic cell chemotaxis (GO:0002407)2.56969347
93rRNA methylation (GO:0031167)2.56829470
94neuronal action potential (GO:0019228)2.56773753
95righting reflex (GO:0060013)2.55586575
96regulation of RIG-I signaling pathway (GO:0039535)2.55519019
97regulation of B cell receptor signaling pathway (GO:0050855)2.54844811
98nucleotide transmembrane transport (GO:1901679)2.54519201
99sperm-egg recognition (GO:0035036)2.54108379
100meiotic chromosome segregation (GO:0045132)2.54004897
101synaptic transmission, cholinergic (GO:0007271)2.52405791
102negative regulation of viral genome replication (GO:0045071)2.51731099
103proteasome assembly (GO:0043248)2.51277262
104positive regulation of T cell mediated cytotoxicity (GO:0001916)2.50917814
105response to protozoan (GO:0001562)2.50332179
106cellular ketone body metabolic process (GO:0046950)2.48881839
107dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.48826276
108spinal cord motor neuron differentiation (GO:0021522)2.45596470
109energy homeostasis (GO:0097009)2.44201295
110behavioral response to ethanol (GO:0048149)2.43961218
111myeloid dendritic cell differentiation (GO:0043011)2.43820351
112DNA replication-dependent nucleosome organization (GO:0034723)2.43740362
113DNA replication-dependent nucleosome assembly (GO:0006335)2.43740362
114generation of neurons (GO:0048699)2.43458737
115regulation of T cell mediated cytotoxicity (GO:0001914)2.42621122
116gonadal mesoderm development (GO:0007506)2.42453448
117rRNA modification (GO:0000154)2.42108012
118meiotic nuclear division (GO:0007126)2.42088328
119water-soluble vitamin biosynthetic process (GO:0042364)2.41840063
120positive regulation of action potential (GO:0045760)2.41232443
121CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.41103671
122viral genome replication (GO:0019079)2.40443798
123negative regulation of cell aging (GO:0090344)2.40076197
124protein kinase C signaling (GO:0070528)2.39959955
125regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.39494962
126negative regulation of hormone biosynthetic process (GO:0032353)2.39072024
127neurotransmitter-gated ion channel clustering (GO:0072578)2.38951476
128mast cell activation involved in immune response (GO:0002279)2.38066449
129mast cell degranulation (GO:0043303)2.38066449
130dendritic cell migration (GO:0036336)2.37672072
131DNA double-strand break processing (GO:0000729)2.36827491
132type B pancreatic cell development (GO:0003323)2.36379125
133cAMP catabolic process (GO:0006198)2.35208134
134T cell lineage commitment (GO:0002360)2.34520138
135DNA integration (GO:0015074)2.32344673
136regulation of pigment cell differentiation (GO:0050932)2.32160456
137mature B cell differentiation involved in immune response (GO:0002313)2.31361015
138type I interferon signaling pathway (GO:0060337)2.30675724
139cellular response to type I interferon (GO:0071357)2.30675724
140neutrophil activation involved in immune response (GO:0002283)2.30633884
141regulation of histone H3-K9 methylation (GO:0051570)2.30296379
142meiotic cell cycle process (GO:1903046)2.30293236
143interferon-gamma production (GO:0032609)2.30197001
144replication fork processing (GO:0031297)2.29927130
145synaptonemal complex assembly (GO:0007130)2.29093386
146RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.28821941
147tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.28821941
148synaptonemal complex organization (GO:0070193)2.28578372
149reciprocal DNA recombination (GO:0035825)2.27267367
150reciprocal meiotic recombination (GO:0007131)2.27267367
151membrane invagination (GO:0010324)2.27248889
152regulation of G2/M transition of mitotic cell cycle (GO:0010389)2.27008181
153neuromuscular synaptic transmission (GO:0007274)2.26942370
154detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.26735270
155cranial nerve morphogenesis (GO:0021602)2.26566567
156negative regulation of transcription regulatory region DNA binding (GO:2000678)2.26170703
157interferon-gamma-mediated signaling pathway (GO:0060333)2.23586213
158regulation of mast cell activation (GO:0033003)2.23278320
159positive regulation of embryonic development (GO:0040019)2.23177487
160telomere maintenance via telomere lengthening (GO:0010833)2.23139993
161ketone body metabolic process (GO:1902224)2.22807774
162developmental pigmentation (GO:0048066)2.21883770
163response to type I interferon (GO:0034340)2.21807791
164daunorubicin metabolic process (GO:0044597)2.20895524
165polyketide metabolic process (GO:0030638)2.20895524
166doxorubicin metabolic process (GO:0044598)2.20895524
167mitotic recombination (GO:0006312)2.20755440
168ribosomal small subunit assembly (GO:0000028)2.19852092
169regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.19706435
170DNA catabolic process, exonucleolytic (GO:0000738)2.19581462
171regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.18944998
172metallo-sulfur cluster assembly (GO:0031163)2.18678607
173iron-sulfur cluster assembly (GO:0016226)2.18678607
174centriole assembly (GO:0098534)2.17895786
175myeloid leukocyte mediated immunity (GO:0002444)2.17773589
176dopamine transport (GO:0015872)2.17337401
177B cell mediated immunity (GO:0019724)2.17135713
178positive regulation of cellular amide metabolic process (GO:0034250)2.16830124
179regulation of nuclear cell cycle DNA replication (GO:0033262)2.16239212
180regulation of macrophage differentiation (GO:0045649)2.15707267
181regulation of MHC class II biosynthetic process (GO:0045346)2.15570493
182startle response (GO:0001964)2.14880803
183mature B cell differentiation (GO:0002335)2.14638258
184DNA synthesis involved in DNA repair (GO:0000731)2.13157671
185regulation of T cell receptor signaling pathway (GO:0050856)2.11269514
186detection of other organism (GO:0098543)2.10173683
187natural killer cell activation involved in immune response (GO:0002323)2.09907338
188kinetochore assembly (GO:0051382)2.09857573
189GDP-mannose metabolic process (GO:0019673)2.08500659
190auditory behavior (GO:0031223)2.08372767
191pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.07194786
192mechanosensory behavior (GO:0007638)2.06723980
193granulocyte differentiation (GO:0030851)2.06708006
194protein localization to synapse (GO:0035418)2.06523131
195C-terminal protein lipidation (GO:0006501)2.05977670
196regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.05718839
197RNA methylation (GO:0001510)2.05309373

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.87732970
2EZH2_22144423_ChIP-Seq_EOC_Human4.48310361
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.06875385
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.21542386
5IRF8_22096565_ChIP-ChIP_GC-B_Human2.83808072
6ZNF274_21170338_ChIP-Seq_K562_Hela2.74126614
7GBX2_23144817_ChIP-Seq_PC3_Human2.73730141
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.72492855
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.71905232
10IGF1R_20145208_ChIP-Seq_DFB_Human2.62475544
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.56292395
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.40557205
13NOTCH1_21737748_ChIP-Seq_TLL_Human2.40251416
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.28252161
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.27830057
16PCGF2_27294783_Chip-Seq_ESCs_Mouse2.24004285
17VDR_22108803_ChIP-Seq_LS180_Human2.21404415
18RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.20042506
19PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.18467002
20E2F7_22180533_ChIP-Seq_HELA_Human2.18127851
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.17183900
22SCL_19346495_ChIP-Seq_HPC-7_Human2.16149400
23* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.10495698
24SMAD_19615063_ChIP-ChIP_OVARY_Human2.08981935
25LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.03271933
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.01065957
27MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.98853523
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.98491038
29FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.92968838
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.78480811
31EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.77873817
32ELF1_17652178_ChIP-ChIP_JURKAT_Human1.77051212
33SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.74026747
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.73431731
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.68232750
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.65734016
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.63487993
38NFE2_27457419_Chip-Seq_LIVER_Mouse1.62341916
39HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.61782347
40SALL1_21062744_ChIP-ChIP_HESCs_Human1.60916564
41SUZ12_27294783_Chip-Seq_NPCs_Mouse1.59675607
42RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.58851348
43STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.58712284
44CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.57074288
45FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.57038984
46KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.56728392
47JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.56487743
48HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.53253762
49CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.52667178
50EZH2_27304074_Chip-Seq_ESCs_Mouse1.51821675
51ER_23166858_ChIP-Seq_MCF-7_Human1.50943181
52TP53_22573176_ChIP-Seq_HFKS_Human1.50725339
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.45749590
54STAT3_18555785_Chip-Seq_ESCs_Mouse1.42481851
55SRF_21415370_ChIP-Seq_HL-1_Mouse1.40577421
56* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40396616
57* CBP_20019798_ChIP-Seq_JUKART_Human1.40396616
58FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.39427728
59NMYC_18555785_Chip-Seq_ESCs_Mouse1.39136757
60GABP_17652178_ChIP-ChIP_JURKAT_Human1.38942701
61UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.38791505
62STAT4_19710469_ChIP-ChIP_TH1__Mouse1.38397158
63RNF2_27304074_Chip-Seq_NSC_Mouse1.37394459
64SPI1_23547873_ChIP-Seq_NB4_Human1.37187053
65MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.36922458
66HOXB4_20404135_ChIP-ChIP_EML_Mouse1.35108544
67EZH2_27294783_Chip-Seq_NPCs_Mouse1.32972481
68P53_22387025_ChIP-Seq_ESCs_Mouse1.32473570
69SUZ12_18555785_Chip-Seq_ESCs_Mouse1.30771338
70EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.29932339
71EWS_26573619_Chip-Seq_HEK293_Human1.29747546
72SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.29675525
73AR_25329375_ChIP-Seq_VCAP_Human1.29468769
74E2F1_18555785_Chip-Seq_ESCs_Mouse1.28877580
75IRF8_27001747_Chip-Seq_BMDM_Mouse1.28609908
76TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28511627
77NANOG_18555785_Chip-Seq_ESCs_Mouse1.28115214
78CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27641256
79* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.27067771
80LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.26959464
81NANOG_20526341_ChIP-Seq_ESCs_Human1.25821163
82RUNX1_27457419_Chip-Seq_LIVER_Mouse1.24390110
83STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.24259231
84SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.24247414
85MYC_18940864_ChIP-ChIP_HL60_Human1.23649441
86BCAT_22108803_ChIP-Seq_LS180_Human1.22989241
87BMI1_23680149_ChIP-Seq_NPCS_Mouse1.22621696
88IRF1_19129219_ChIP-ChIP_H3396_Human1.22393414
89NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.20198926
90POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19877400
91TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19877400
92EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.19853784
93TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19835120
94VDR_23849224_ChIP-Seq_CD4+_Human1.19709682
95EED_16625203_ChIP-ChIP_MESCs_Mouse1.19468699
96SOX2_18555785_Chip-Seq_ESCs_Mouse1.18977931
97CMYC_18555785_Chip-Seq_ESCs_Mouse1.18338000
98PCGF2_27294783_Chip-Seq_NPCs_Mouse1.17829264
99EZH2_27294783_Chip-Seq_ESCs_Mouse1.17395536
100P300_19829295_ChIP-Seq_ESCs_Human1.15196301
101P300_18555785_Chip-Seq_ESCs_Mouse1.14085183
102* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13427110
103SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13377612
104TCF4_23295773_ChIP-Seq_U87_Human1.13348239
105PU1_27457419_Chip-Seq_LIVER_Mouse1.13072137
106STAT3_23295773_ChIP-Seq_U87_Human1.13058524
107GATA3_21878914_ChIP-Seq_MCF-7_Human1.12992554
108* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.12623830
109RUNX2_22187159_ChIP-Seq_PCA_Human1.12339568
110SMAD4_21799915_ChIP-Seq_A2780_Human1.12216107
111SMAD4_21741376_ChIP-Seq_EPCs_Human1.11975051
112FUS_26573619_Chip-Seq_HEK293_Human1.11935190
113AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11640830
114JARID2_20064375_ChIP-Seq_MESCs_Mouse1.11464631
115SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.11210685
116ZFX_18555785_Chip-Seq_ESCs_Mouse1.10133853
117MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.09999085
118OCT4_18555785_Chip-Seq_ESCs_Mouse1.09316058
119TAF15_26573619_Chip-Seq_HEK293_Human1.07940393
120SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07930648
121FOXA1_25329375_ChIP-Seq_VCAP_Human1.07795895
122FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07795895
123TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.07427070
124NCOR_22424771_ChIP-Seq_293T_Human1.07262600
125CTCF_18555785_Chip-Seq_ESCs_Mouse1.06434106
126TAL1_26923725_Chip-Seq_HPCs_Mouse1.05475461
127ELK1_19687146_ChIP-ChIP_HELA_Human1.05331110
128IKZF1_21737484_ChIP-ChIP_HCT116_Human1.04638186
129* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04595445
130PRDM14_20953172_ChIP-Seq_ESCs_Human1.04039472
131SMAD1_18555785_Chip-Seq_ESCs_Mouse1.03764825
132RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.03353153
133SOX2_19829295_ChIP-Seq_ESCs_Human1.03227162
134NANOG_19829295_ChIP-Seq_ESCs_Human1.03227162
135REST_21632747_ChIP-Seq_MESCs_Mouse1.03020964
136MYB_21317192_ChIP-Seq_ERMYB_Mouse1.02960508
137TP63_19390658_ChIP-ChIP_HaCaT_Human1.02698702
138NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01844060
139KLF4_18555785_Chip-Seq_ESCs_Mouse1.01103635
140EST1_17652178_ChIP-ChIP_JURKAT_Human1.01093132
141EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.00084245
142ESRRB_18555785_Chip-Seq_ESCs_Mouse0.98836135
143FOXH1_21741376_ChIP-Seq_EPCs_Human0.97484053
144SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.97273520
145SMAD3_21741376_ChIP-Seq_EPCs_Human0.96899576
146HOXB7_26014856_ChIP-Seq_BT474_Human0.96435611
147GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.96405115
148SUZ12_27294783_Chip-Seq_ESCs_Mouse0.95876669
149CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.95846860
150HTT_18923047_ChIP-ChIP_STHdh_Human0.95814012
151CBX2_27304074_Chip-Seq_ESCs_Mouse0.95645803
152GATA1_26923725_Chip-Seq_HPCs_Mouse0.95283138
153MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95064377
154AR_20517297_ChIP-Seq_VCAP_Human0.94599462
155THAP11_20581084_ChIP-Seq_MESCs_Mouse0.94068392
156PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92909027
157TAF2_19829295_ChIP-Seq_ESCs_Human0.92576660
158* CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.91698921
159NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.91393592
160ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.90215439
161FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.90052247
162HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.89564314
163ERA_21632823_ChIP-Seq_H3396_Human0.89207612
164* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.85825231
165SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85460115
166JARID2_20075857_ChIP-Seq_MESCs_Mouse0.84739462
167CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.84613375
168FOXA1_21572438_ChIP-Seq_LNCaP_Human0.84401404
169MYC_19829295_ChIP-Seq_ESCs_Human0.83836332
170LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83735019
171PIAS1_25552417_ChIP-Seq_VCAP_Human0.82971490
172AUTS2_25519132_ChIP-Seq_293T-REX_Human0.82221179

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect4.28815685
2MP0001188_hyperpigmentation3.71035040
3MP0006292_abnormal_olfactory_placode3.60797871
4MP0000015_abnormal_ear_pigmentation3.07652708
5MP0001835_abnormal_antigen_presentation2.75562146
6MP0005174_abnormal_tail_pigmentation2.71953769
7MP0002876_abnormal_thyroid_physiology2.45123526
8MP0005671_abnormal_response_to2.37501870
9MP0001986_abnormal_taste_sensitivity2.36525919
10MP0009785_altered_susceptibility_to2.31561303
11MP0005409_darkened_coat_color2.25619872
12MP0003880_abnormal_central_pattern2.19741254
13MP0002160_abnormal_reproductive_system2.14765579
14MP0002148_abnormal_hypersensitivity_rea2.11957650
15MP0008789_abnormal_olfactory_epithelium2.11113580
16MP0002837_dystrophic_cardiac_calcinosis2.10886265
17MP0005646_abnormal_pituitary_gland2.05383256
18MP0003195_calcinosis1.98865218
19MP0005075_abnormal_melanosome_morpholog1.96817845
20MP0004145_abnormal_muscle_electrophysio1.95519940
21MP0002638_abnormal_pupillary_reflex1.93180804
22MP0009379_abnormal_foot_pigmentation1.92198550
23MP0002095_abnormal_skin_pigmentation1.86286573
24MP0003724_increased_susceptibility_to1.83993885
25MP0005551_abnormal_eye_electrophysiolog1.80714643
26MP0005645_abnormal_hypothalamus_physiol1.80022652
27MP0000681_abnormal_thyroid_gland1.75886608
28MP0005360_urolithiasis1.73396039
29MP0003763_abnormal_thymus_physiology1.69915856
30MP0000372_irregular_coat_pigmentation1.67188908
31MP0002396_abnormal_hematopoietic_system1.65939256
32MP0002210_abnormal_sex_determination1.65916333
33MP0008058_abnormal_DNA_repair1.64990673
34MP0003890_abnormal_embryonic-extraembry1.64899989
35MP0004142_abnormal_muscle_tone1.63178783
36MP0005000_abnormal_immune_tolerance1.61785832
37MP0005025_abnormal_response_to1.61250045
38MP0004859_abnormal_synaptic_plasticity1.60403334
39MP0003787_abnormal_imprinting1.59606139
40MP0001929_abnormal_gametogenesis1.58160707
41MP0003646_muscle_fatigue1.56082268
42MP0005389_reproductive_system_phenotype1.53883271
43MP0005395_other_phenotype1.51779448
44MP0002419_abnormal_innate_immunity1.49969235
45MP0005499_abnormal_olfactory_system1.48989744
46MP0005394_taste/olfaction_phenotype1.48989744
47MP0002234_abnormal_pharynx_morphology1.48635302
48MP0010386_abnormal_urinary_bladder1.46396196
49MP0002420_abnormal_adaptive_immunity1.45642678
50MP0000569_abnormal_digit_pigmentation1.45436756
51MP0001819_abnormal_immune_cell1.45305588
52MP0002723_abnormal_immune_serum1.44036312
53MP0000685_abnormal_immune_system1.43403077
54MP0003436_decreased_susceptibility_to1.42096605
55MP0002452_abnormal_antigen_presenting1.41208950
56MP0006276_abnormal_autonomic_nervous1.41022964
57MP0008877_abnormal_DNA_methylation1.39240337
58MP0005410_abnormal_fertilization1.38454568
59MP0010030_abnormal_orbit_morphology1.36707203
60MP0008260_abnormal_autophagy1.36461495
61MP0003879_abnormal_hair_cell1.35047141
62MP0001800_abnormal_humoral_immune1.34480622
63MP0009745_abnormal_behavioral_response1.33773305
64MP0005387_immune_system_phenotype1.32428906
65MP0001790_abnormal_immune_system1.32428906
66MP0001968_abnormal_touch/_nociception1.31821403
67MP0002398_abnormal_bone_marrow1.31280191
68MP0002138_abnormal_hepatobiliary_system1.28778978
69MP0003635_abnormal_synaptic_transmissio1.27402196
70MP0000653_abnormal_sex_gland1.26923229
71MP0002735_abnormal_chemical_nociception1.26588494
72MP0006072_abnormal_retinal_apoptosis1.26472135
73MP0001905_abnormal_dopamine_level1.25546679
74MP0009333_abnormal_splenocyte_physiolog1.25497607
75MP0000490_abnormal_crypts_of1.24421534
76MP0001502_abnormal_circadian_rhythm1.24358915
77MP0005423_abnormal_somatic_nervous1.24050767
78MP0001919_abnormal_reproductive_system1.22014862
79MP0004215_abnormal_myocardial_fiber1.21057548
80MP0000427_abnormal_hair_cycle1.18547179
81MP0003699_abnormal_female_reproductive1.17539369
82MP0004043_abnormal_pH_regulation1.16501218
83MP0002928_abnormal_bile_duct1.16293145
84MP0000566_synostosis1.16206699
85MP0008007_abnormal_cellular_replicative1.13146918
86MP0000716_abnormal_immune_system1.12520349
87MP0005397_hematopoietic_system_phenotyp1.11251389
88MP0001545_abnormal_hematopoietic_system1.11251389
89MP0005464_abnormal_platelet_physiology1.11140968
90MP0008995_early_reproductive_senescence1.10363825
91MP0003698_abnormal_male_reproductive1.10159560
92MP0002572_abnormal_emotion/affect_behav1.09266288
93MP0001293_anophthalmia1.08247179
94MP0003183_abnormal_peptide_metabolism1.08155091
95MP0001145_abnormal_male_reproductive1.08062017
96MP0002736_abnormal_nociception_after1.06774770
97MP0001529_abnormal_vocalization1.06147787
98MP0002063_abnormal_learning/memory/cond1.05714861
99MP0000678_abnormal_parathyroid_gland1.04133957
100MP0002132_abnormal_respiratory_system1.03837758
101MP0002653_abnormal_ependyma_morphology1.03729249
102MP0004808_abnormal_hematopoietic_stem1.03498990
103MP0003136_yellow_coat_color1.03315778
104MP0010234_abnormal_vibrissa_follicle1.02830294
105MP0001984_abnormal_olfaction1.02791676
106MP0004885_abnormal_endolymph1.02696479
107MP0000631_abnormal_neuroendocrine_gland1.02542874
108MP0003119_abnormal_digestive_system1.01711869
109MP0010094_abnormal_chromosome_stability1.00375686
110MP0004381_abnormal_hair_follicle0.99394802
111MP0003786_premature_aging0.99046212
112MP0000689_abnormal_spleen_morphology0.98834631
113MP0005253_abnormal_eye_physiology0.98580762
114MP0005171_absent_coat_pigmentation0.98235273
115MP0002277_abnormal_respiratory_mucosa0.97916509
116MP0002557_abnormal_social/conspecific_i0.97765210
117MP0008875_abnormal_xenobiotic_pharmacok0.97391628
118MP0001486_abnormal_startle_reflex0.96733966
119MP0002161_abnormal_fertility/fecundity0.96620747
120MP0002734_abnormal_mechanical_nocicepti0.96014765
121MP0002163_abnormal_gland_morphology0.95286786
122MP0001186_pigmentation_phenotype0.94477567
123MP0009697_abnormal_copulation0.94296970
124MP0001664_abnormal_digestion0.93235255
125MP0002822_catalepsy0.92774482
126MP0001853_heart_inflammation0.92045541
127MP0002429_abnormal_blood_cell0.91687719
128MP0003121_genomic_imprinting0.91627531
129MP0002272_abnormal_nervous_system0.91209923
130MP0002075_abnormal_coat/hair_pigmentati0.90881310
131MP0001324_abnormal_eye_pigmentation0.90487177
132MP0002006_tumorigenesis0.89788867
133MP0004782_abnormal_surfactant_physiolog0.89606915
134MP0002177_abnormal_outer_ear0.89350241
135MP0002067_abnormal_sensory_capabilities0.88541171
136MP0002722_abnormal_immune_system0.87057892
137MP0008057_abnormal_DNA_replication0.87016776
138MP0002405_respiratory_system_inflammati0.86774754
139MP0001970_abnormal_pain_threshold0.86148774
140MP0002102_abnormal_ear_morphology0.86122771
141MP0001756_abnormal_urination0.85997269
142MP0003693_abnormal_embryo_hatching0.85583767
143MP0001119_abnormal_female_reproductive0.84754414
144MP0009046_muscle_twitch0.84737361
145MP0001501_abnormal_sleep_pattern0.83545253
146MP0000026_abnormal_inner_ear0.83125589
147MP0002938_white_spotting0.82557010
148MP0001944_abnormal_pancreas_morphology0.82544546
149MP0004133_heterotaxia0.80769440
150MP0002751_abnormal_autonomic_nervous0.80448468
151MP0000538_abnormal_urinary_bladder0.78499029
152MP0006036_abnormal_mitochondrial_physio0.78405262
153MP0005084_abnormal_gallbladder_morpholo0.78233796
154MP0004924_abnormal_behavior0.78023290
155MP0005386_behavior/neurological_phenoty0.78023290
156MP0002909_abnormal_adrenal_gland0.77554774
157MP0002139_abnormal_hepatobiliary_system0.76430052
158MP0005195_abnormal_posterior_eye0.75462624
159MP0002064_seizures0.74112730
160MP0000778_abnormal_nervous_system0.72721301
161MP0002752_abnormal_somatic_nervous0.72615772
162MP0000049_abnormal_middle_ear0.72179018

Predicted human phenotypes

RankGene SetZ-score
1Type I transferrin isoform profile (HP:0003642)5.26830414
2Reduced antithrombin III activity (HP:0001976)4.78443474
3Hypothermia (HP:0002045)3.96240891
4Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.67351830
5Abnormal protein N-linked glycosylation (HP:0012347)3.67351830
6Abnormal protein glycosylation (HP:0012346)3.67351830
7Abnormal glycosylation (HP:0012345)3.67351830
8Congenital stationary night blindness (HP:0007642)3.66680315
9Aplastic anemia (HP:0001915)3.49327728
10Supernumerary spleens (HP:0009799)3.48625920
11Type 2 muscle fiber atrophy (HP:0003554)3.42979087
12Abnormality of midbrain morphology (HP:0002418)3.38811971
13Molar tooth sign on MRI (HP:0002419)3.38811971
14Myositis (HP:0100614)3.35921022
15Recurrent abscess formation (HP:0002722)3.27096316
16Facial hemangioma (HP:0000329)3.21224086
17Thyroid-stimulating hormone excess (HP:0002925)3.19773455
18Chromosomal breakage induced by crosslinking agents (HP:0003221)3.19735200
19Focal motor seizures (HP:0011153)3.02186245
20Chromsome breakage (HP:0040012)3.00586990
21Elevated erythrocyte sedimentation rate (HP:0003565)2.98505692
22Anterior segment dysgenesis (HP:0007700)2.97424959
23Muscle fiber atrophy (HP:0100295)2.94767884
24True hermaphroditism (HP:0010459)2.93156474
25Optic neuritis (HP:0100653)2.91666689
26Retrobulbar optic neuritis (HP:0100654)2.91666689
27Hypophosphatemic rickets (HP:0004912)2.82694512
28Absent rod-and cone-mediated responses on ERG (HP:0007688)2.81877218
29Oligodactyly (hands) (HP:0001180)2.80059198
30Febrile seizures (HP:0002373)2.77987220
31Nonprogressive disorder (HP:0003680)2.76718824
32Bony spicule pigmentary retinopathy (HP:0007737)2.76588041
33Type II lissencephaly (HP:0007260)2.76276156
34Polydipsia (HP:0001959)2.75305603
35Abnormal drinking behavior (HP:0030082)2.75305603
36Recurrent bacterial skin infections (HP:0005406)2.72955135
37Abnormal hair whorl (HP:0010721)2.72044940
38Mediastinal lymphadenopathy (HP:0100721)2.71362591
39Testicular atrophy (HP:0000029)2.71057372
40Nephronophthisis (HP:0000090)2.62023986
41Calf muscle hypertrophy (HP:0008981)2.59046881
42Severe visual impairment (HP:0001141)2.58100973
43Muscle hypertrophy of the lower extremities (HP:0008968)2.56539966
44Abnormality of the fovea (HP:0000493)2.56396099
45Rib fusion (HP:0000902)2.53357823
46Abdominal situs inversus (HP:0003363)2.51917671
47Abnormality of abdominal situs (HP:0011620)2.51917671
48Pendular nystagmus (HP:0012043)2.51602275
49Obstructive lung disease (HP:0006536)2.46584175
50Chronic obstructive pulmonary disease (HP:0006510)2.46584175
51Pancreatic fibrosis (HP:0100732)2.46101157
52Abnormality of the prostate (HP:0008775)2.45838054
53Petechiae (HP:0000967)2.42920943
54Congenital sensorineural hearing impairment (HP:0008527)2.42116774
55Orchitis (HP:0100796)2.40780413
56Septo-optic dysplasia (HP:0100842)2.39953947
57Meningitis (HP:0001287)2.39415525
58Tubular atrophy (HP:0000092)2.36478185
59Thrombocytosis (HP:0001894)2.33801441
60Aplasia of the musculature (HP:0100854)2.32981342
61Lipid accumulation in hepatocytes (HP:0006561)2.32142298
62Clubbing of toes (HP:0100760)2.31719363
63Abnormality of the renal cortex (HP:0011035)2.29836406
64Impulsivity (HP:0100710)2.29415874
65Abnormal biliary tract physiology (HP:0012439)2.29409613
66Bile duct proliferation (HP:0001408)2.29409613
67Abnormality of the renal medulla (HP:0100957)2.27284980
68Absent thumb (HP:0009777)2.27052044
69Protruding tongue (HP:0010808)2.25257016
70Methylmalonic acidemia (HP:0002912)2.24827635
71Stomatitis (HP:0010280)2.24769096
72Patellar aplasia (HP:0006443)2.24359714
73Abnormal delayed hypersensitivity skin test (HP:0002963)2.21935937
74Chronic hepatic failure (HP:0100626)2.18105418
75Abnormal rod and cone electroretinograms (HP:0008323)2.14809744
76Aplasia/Hypoplasia of the tongue (HP:0010295)2.13064634
77Aplasia/Hypoplasia of the patella (HP:0006498)2.12186545
78Eczematoid dermatitis (HP:0000976)2.11815936
79Aplasia/Hypoplasia involving the musculature (HP:0001460)2.11745295
80Dry hair (HP:0011359)2.10995309
81Pancreatic cysts (HP:0001737)2.10425767
82IgM deficiency (HP:0002850)2.09191775
83Concave nail (HP:0001598)2.08777759
84Abnormality of the columella (HP:0009929)2.08515345
85Abnormality of the preputium (HP:0100587)2.08111465
86Chronic mucocutaneous candidiasis (HP:0002728)2.06430214
87Recurrent cutaneous fungal infections (HP:0011370)2.06430214
88Gaze-evoked nystagmus (HP:0000640)2.05564441
89Cerebellar dysplasia (HP:0007033)2.05505501
90Dynein arm defect of respiratory motile cilia (HP:0012255)2.04601497
91Absent/shortened dynein arms (HP:0200106)2.04601497
92Generalized hypopigmentation of hair (HP:0011358)2.03778846
93Abnormality of DNA repair (HP:0003254)2.02187710
94Absent septum pellucidum (HP:0001331)2.01560429
95Lip pit (HP:0100267)2.01509606
96Basal ganglia calcification (HP:0002135)2.00555597
97Aplasia/Hypoplasia of the tibia (HP:0005772)2.00324322
98Hypoplasia of the pons (HP:0012110)2.00321165
99Fetal akinesia sequence (HP:0001989)2.00123118
100Decreased circulating renin level (HP:0003351)1.98860454
101Panhypogammaglobulinemia (HP:0003139)1.98741489
102Birth length less than 3rd percentile (HP:0003561)1.98734667
103Fair hair (HP:0002286)1.97658446
104Chorioretinal atrophy (HP:0000533)1.97605203
105Increased IgM level (HP:0003496)1.97275465
106Abnormality of the pons (HP:0007361)1.97258595
107Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.97043946
1083-Methylglutaconic aciduria (HP:0003535)1.96987063
109Abnormality of chromosome stability (HP:0003220)1.96821786
110Median cleft lip (HP:0000161)1.96604432
111Aplasia/Hypoplasia of the uvula (HP:0010293)1.96111584
112IgG deficiency (HP:0004315)1.96101262
113Prolonged bleeding time (HP:0003010)1.96024045
114Popliteal pterygium (HP:0009756)1.95038869
115Exertional dyspnea (HP:0002875)1.94885343
116Polyuria (HP:0000103)1.94072250
117Pulmonary fibrosis (HP:0002206)1.91582487
118Short tibia (HP:0005736)1.91305676
119Anencephaly (HP:0002323)1.91073083
120Methylmalonic aciduria (HP:0012120)1.90368382
121Myelodysplasia (HP:0002863)1.88943380
122Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.88496249
123Prostate neoplasm (HP:0100787)1.88447443
124Spinal canal stenosis (HP:0003416)1.87588503
125Enlarged penis (HP:0000040)1.87017597
126Bone marrow hypocellularity (HP:0005528)1.86815161
127Glycosuria (HP:0003076)1.86257638
128Abnormality of urine glucose concentration (HP:0011016)1.86257638
129Decreased central vision (HP:0007663)1.84922894
130Maternal diabetes (HP:0009800)1.84860998
131Albinism (HP:0001022)1.84460060
132Meckel diverticulum (HP:0002245)1.83547401
133Abnormality of the heme biosynthetic pathway (HP:0010472)1.83534238
134Renal cortical cysts (HP:0000803)1.82958790
135Optic nerve hypoplasia (HP:0000609)1.82702504
136Oligodactyly (HP:0012165)1.82571843
137Recurrent fungal infections (HP:0002841)1.82361181
138Abnormality of the ileum (HP:0001549)1.82229480
139Diminished movement (HP:0002374)1.82083059
140Osteomalacia (HP:0002749)1.81851728
141Cystic liver disease (HP:0006706)1.81404234
142Hypoplasia of the fovea (HP:0007750)1.80374410
143Aplasia/Hypoplasia of the fovea (HP:0008060)1.80374410
144Capillary hemangiomas (HP:0005306)1.80013445
145Hyperinsulinemic hypoglycemia (HP:0000825)1.79250648
146Aplasia/hypoplasia of the uterus (HP:0008684)1.79148795
147Abnormal ciliary motility (HP:0012262)1.78596109
148Ketoacidosis (HP:0001993)1.78430593
149Epileptic encephalopathy (HP:0200134)1.76336925
150Abnormality of T cell physiology (HP:0011840)1.76206199
151Mitochondrial inheritance (HP:0001427)1.75768517
152Gonadotropin excess (HP:0000837)1.75543969
153Increased CSF lactate (HP:0002490)1.75055767
154Large for gestational age (HP:0001520)1.74872712
155Encephalitis (HP:0002383)1.74610348
156Optic nerve coloboma (HP:0000588)1.73858270
157Vasculitis (HP:0002633)1.73523942
158Attenuation of retinal blood vessels (HP:0007843)1.73033474
159Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.73013763
160Acute necrotizing encephalopathy (HP:0006965)1.72837431
161Increased hepatocellular lipid droplets (HP:0006565)1.72725873
162Recurrent skin infections (HP:0001581)1.72304173
163Hypokinesia (HP:0002375)1.71697342
164Abnormality of alanine metabolism (HP:0010916)1.71575264
165Hyperalaninemia (HP:0003348)1.71575264
166Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.71575264
167Absent forearm bone (HP:0003953)1.71523417
168Aplasia involving forearm bones (HP:0009822)1.71523417
169Nephrogenic diabetes insipidus (HP:0009806)1.70481709
170Medial flaring of the eyebrow (HP:0010747)1.69900527
171Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.68811688
172Recurrent pneumonia (HP:0006532)1.67556930
173Cortical visual impairment (HP:0100704)1.67370547
174Glomerulopathy (HP:0100820)1.66822516
175Renal Fanconi syndrome (HP:0001994)1.66583562
176Iris hypopigmentation (HP:0007730)1.65762642
177Pancytopenia (HP:0001876)1.65672555
178Acute lymphatic leukemia (HP:0006721)1.64748067
179Agammaglobulinemia (HP:0004432)1.63759750
180Preaxial hand polydactyly (HP:0001177)1.62663872
181Poor suck (HP:0002033)1.61683300
182Pulmonary infiltrates (HP:0002113)1.60170956
183Abnormality of male internal genitalia (HP:0000022)1.59872994
184Gait imbalance (HP:0002141)1.59100620

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK5.31746739
2MAP3K94.14148966
3MUSK3.65234925
4MAP2K73.41645803
5STK163.10492359
6MAP3K133.08605430
7FRK3.07597833
8ARAF2.85161708
9CASK2.82965856
10OBSCN2.76594476
11MAP3K122.75154236
12MKNK22.67124640
13WNK42.66267685
14IRAK42.46932246
15CAMKK22.42505395
16EIF2AK32.34588159
17TXK2.19081647
18PHKG12.14308805
19PHKG22.14308805
20IRAK32.07713447
21MAPK151.99486492
22NLK1.86649233
23SIK31.73385168
24WNK31.71237857
25KIT1.68230019
26TEC1.64566203
27BMPR21.63896627
28TRIM281.62782094
29MAP3K141.61114599
30STK391.59982384
31NUAK11.52652644
32PRPF4B1.50895543
33EIF2AK21.50738812
34GRK11.50619307
35MKNK11.49375698
36ADRBK21.49022703
37VRK11.48763065
38CDK191.45220044
39RIPK41.43535564
40ZAK1.41863796
41YES11.41843329
42CCNB11.39909828
43MAPK131.39079642
44OXSR11.31587606
45NME21.29217252
46AURKA1.28115888
47PNCK1.28004889
48ERBB31.27779598
49CDK81.20806805
50INSRR1.20176308
51PIM21.18808059
52CDK31.14502465
53MOS1.14298426
54PLK41.13818337
55STK38L1.13406633
56NTRK31.12675388
57MAP4K21.09331418
58IKBKE1.07291550
59CAMKK11.06927829
60NEK21.06558904
61PINK11.03934267
62IKBKB1.03410707
63MARK11.02430399
64JAK31.02217881
65FES1.01580623
66SRPK10.99141713
67SYK0.97732442
68TTK0.96101517
69ACVR1B0.95979700
70DAPK10.94724918
71CAMK10.94312638
72PRKCI0.93813613
73BTK0.91994214
74PLK10.91678372
75CDC70.88474642
76BMPR1B0.86402472
77STK30.86061346
78MAP3K60.84371394
79RAF10.78167661
80PKN10.77906376
81SGK20.77851041
82TBK10.75564570
83CDK90.74637483
84MAPKAPK30.73866791
85TNK20.73756406
86MAP3K40.72977204
87GRK70.72733776
88DYRK20.72711831
89IRAK10.71642412
90LYN0.69558699
91NEK60.68847056
92CSNK1G10.66966271
93MET0.66229101
94MARK30.64568031
95AKT30.64429323
96TAOK20.63505816
97ADRBK10.62772154
98TGFBR10.62471365
99MAPKAPK50.60976994
100TRPM70.59269530
101WEE10.58253008
102CSNK1D0.58027714
103IRAK20.57049621
104MAP4K10.56297788
105CHEK20.56022223
106CSF1R0.55110154
107PRKG20.54899365
108CSNK1G30.54130361
109ZAP700.52882160
110ATR0.51894772
111PLK30.51643076
112CLK10.51152885
113PRKG10.51026043
114CHUK0.50393277
115CSNK1G20.50326320
116PRKACA0.50269643
117STK240.50104934
118MATK0.49770118
119TIE10.48005148
120CAMK40.47652273
121MST40.43925231
122PIM10.42904884
123CAMK2D0.42804805
124PRKCZ0.42431187
125WNK10.42344541
126PRKAA10.41821092
127BUB10.41450880
128PLK20.40895881
129BRAF0.40853332
130MAPK40.40070696
131BRSK20.39783220
132NTRK20.38992311
133LCK0.37907669
134ATM0.37668582
135RPS6KB10.36930620
136KSR10.35424651
137MAP2K60.34851458
138RPS6KA50.33642617
139PRKAA20.33409504
140PRKCQ0.33111925
141DYRK30.32899812
142KSR20.32863331
143DAPK20.32474924
144DYRK1A0.32437191
145HCK0.32177896
146PRKACB0.32014925
147PRKCD0.31970152
148AURKB0.31365795
149CDK50.30934962
150CSNK1E0.30487575
151BRSK10.30407664
152PDK20.30156989
153GRK50.29942225
154CSNK1A1L0.29911013
155CDK10.29847464
156MINK10.29575801
157FLT30.29179452
158PRKCG0.28193759
159TYK20.27397047
160SIK20.26102111
161TGFBR20.26098033
162TAOK30.25664285
163CAMK2A0.24221014
164TLK10.24176690
165HIPK20.23849013

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.43212249
2Maturity onset diabetes of the young_Homo sapiens_hsa049502.67490443
3DNA replication_Homo sapiens_hsa030302.54431426
4Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.33962061
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.17297258
6Oxidative phosphorylation_Homo sapiens_hsa001902.05983543
7Homologous recombination_Homo sapiens_hsa034401.96696990
8Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.93717600
9Nicotine addiction_Homo sapiens_hsa050331.92155856
10Ovarian steroidogenesis_Homo sapiens_hsa049131.91226621
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.84904184
12Base excision repair_Homo sapiens_hsa034101.80594934
13Caffeine metabolism_Homo sapiens_hsa002321.77773646
14Allograft rejection_Homo sapiens_hsa053301.75194468
15Graft-versus-host disease_Homo sapiens_hsa053321.75149913
16Fanconi anemia pathway_Homo sapiens_hsa034601.73810927
17Type I diabetes mellitus_Homo sapiens_hsa049401.73125256
18Parkinsons disease_Homo sapiens_hsa050121.71364906
19Cardiac muscle contraction_Homo sapiens_hsa042601.70140524
20Mismatch repair_Homo sapiens_hsa034301.70040519
21Butanoate metabolism_Homo sapiens_hsa006501.66892813
22RNA polymerase_Homo sapiens_hsa030201.66788685
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.65806794
24Protein export_Homo sapiens_hsa030601.57229659
25Primary immunodeficiency_Homo sapiens_hsa053401.56132325
26RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.51391781
27Folate biosynthesis_Homo sapiens_hsa007901.47823778
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.44146362
29N-Glycan biosynthesis_Homo sapiens_hsa005101.43932199
30Intestinal immune network for IgA production_Homo sapiens_hsa046721.43657867
31Linoleic acid metabolism_Homo sapiens_hsa005911.43470789
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.40647211
33Basal transcription factors_Homo sapiens_hsa030221.39706862
34Nitrogen metabolism_Homo sapiens_hsa009101.39451949
35NF-kappa B signaling pathway_Homo sapiens_hsa040641.39153731
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.38961775
37Pyrimidine metabolism_Homo sapiens_hsa002401.38241610
38Leishmaniasis_Homo sapiens_hsa051401.37761093
39SNARE interactions in vesicular transport_Homo sapiens_hsa041301.36043683
40Rheumatoid arthritis_Homo sapiens_hsa053231.34555047
41Nucleotide excision repair_Homo sapiens_hsa034201.34107159
42Dorso-ventral axis formation_Homo sapiens_hsa043201.32644595
43Measles_Homo sapiens_hsa051621.32558838
44Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.32175368
45Selenocompound metabolism_Homo sapiens_hsa004501.28145680
46Huntingtons disease_Homo sapiens_hsa050161.25179744
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.24880998
48Oocyte meiosis_Homo sapiens_hsa041141.24784036
49Other glycan degradation_Homo sapiens_hsa005111.23989075
50Synaptic vesicle cycle_Homo sapiens_hsa047211.23541763
51Sulfur relay system_Homo sapiens_hsa041221.23194604
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.22744202
53Herpes simplex infection_Homo sapiens_hsa051681.22172371
54Toll-like receptor signaling pathway_Homo sapiens_hsa046201.21689953
55Non-homologous end-joining_Homo sapiens_hsa034501.20683904
56Autoimmune thyroid disease_Homo sapiens_hsa053201.18848991
57RNA degradation_Homo sapiens_hsa030181.16727524
58Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.13497220
59Hematopoietic cell lineage_Homo sapiens_hsa046401.12077070
60Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.11752441
61Tryptophan metabolism_Homo sapiens_hsa003801.11506226
62Asthma_Homo sapiens_hsa053101.10860410
63Morphine addiction_Homo sapiens_hsa050321.10675021
64Cysteine and methionine metabolism_Homo sapiens_hsa002701.07026379
65Proteasome_Homo sapiens_hsa030501.05459469
66Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.05083264
67Collecting duct acid secretion_Homo sapiens_hsa049661.04769810
68Insulin secretion_Homo sapiens_hsa049111.04615487
69Purine metabolism_Homo sapiens_hsa002301.03684039
70Hedgehog signaling pathway_Homo sapiens_hsa043401.03421089
71Alzheimers disease_Homo sapiens_hsa050101.03000225
72Propanoate metabolism_Homo sapiens_hsa006401.00804955
73Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.99477523
74NOD-like receptor signaling pathway_Homo sapiens_hsa046210.98990076
75Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.97552588
76Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.95745520
77Regulation of autophagy_Homo sapiens_hsa041400.92430189
78Serotonergic synapse_Homo sapiens_hsa047260.91626438
79Jak-STAT signaling pathway_Homo sapiens_hsa046300.90805619
80Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.90707470
81ABC transporters_Homo sapiens_hsa020100.90529922
82Olfactory transduction_Homo sapiens_hsa047400.89243576
83Influenza A_Homo sapiens_hsa051640.88530940
84Ribosome_Homo sapiens_hsa030100.87357689
85Tuberculosis_Homo sapiens_hsa051520.86363381
86Osteoclast differentiation_Homo sapiens_hsa043800.85508841
87Pertussis_Homo sapiens_hsa051330.83775922
88Spliceosome_Homo sapiens_hsa030400.83153627
89African trypanosomiasis_Homo sapiens_hsa051430.83143002
90Phagosome_Homo sapiens_hsa041450.81751974
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.80613846
92Circadian entrainment_Homo sapiens_hsa047130.80234218
93Taste transduction_Homo sapiens_hsa047420.80091015
94RNA transport_Homo sapiens_hsa030130.78977715
95Phototransduction_Homo sapiens_hsa047440.78804916
96Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78317323
97Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.77988435
98Ether lipid metabolism_Homo sapiens_hsa005650.77842247
99Glutamatergic synapse_Homo sapiens_hsa047240.75607993
100Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75191824
101Circadian rhythm_Homo sapiens_hsa047100.75045526
102Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74226737
103Chemokine signaling pathway_Homo sapiens_hsa040620.73978947
104Cocaine addiction_Homo sapiens_hsa050300.73594174
105TNF signaling pathway_Homo sapiens_hsa046680.71992738
106Legionellosis_Homo sapiens_hsa051340.71235646
107Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70640704
108Mineral absorption_Homo sapiens_hsa049780.70349890
109Salmonella infection_Homo sapiens_hsa051320.69743566
110Pyruvate metabolism_Homo sapiens_hsa006200.69120612
111Basal cell carcinoma_Homo sapiens_hsa052170.67938650
112Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.67753776
113Cell cycle_Homo sapiens_hsa041100.67382415
114p53 signaling pathway_Homo sapiens_hsa041150.67217083
115Hepatitis B_Homo sapiens_hsa051610.66985581
116Peroxisome_Homo sapiens_hsa041460.66089985
117Vitamin digestion and absorption_Homo sapiens_hsa049770.64974462
118GABAergic synapse_Homo sapiens_hsa047270.64278827
119Malaria_Homo sapiens_hsa051440.63637729
120Cholinergic synapse_Homo sapiens_hsa047250.63321247
121B cell receptor signaling pathway_Homo sapiens_hsa046620.63320987
122Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62994270
123Sphingolipid metabolism_Homo sapiens_hsa006000.62862505
124Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62350351
125Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.62069313
126Thyroid cancer_Homo sapiens_hsa052160.59846273
127Vibrio cholerae infection_Homo sapiens_hsa051100.59137014
128Antigen processing and presentation_Homo sapiens_hsa046120.58546599
129Metabolic pathways_Homo sapiens_hsa011000.58303967
130Glycosaminoglycan degradation_Homo sapiens_hsa005310.58111380
131Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.55969460
132Amphetamine addiction_Homo sapiens_hsa050310.52459653
133Hippo signaling pathway_Homo sapiens_hsa043900.52000330
134Oxytocin signaling pathway_Homo sapiens_hsa049210.51725030
135Chemical carcinogenesis_Homo sapiens_hsa052040.51606245
136Epstein-Barr virus infection_Homo sapiens_hsa051690.51413932
137Fatty acid metabolism_Homo sapiens_hsa012120.51339921
138Apoptosis_Homo sapiens_hsa042100.50078940
139cAMP signaling pathway_Homo sapiens_hsa040240.49971014
140Calcium signaling pathway_Homo sapiens_hsa040200.49496721
141Fatty acid elongation_Homo sapiens_hsa000620.49326470
142Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.49324936
143Shigellosis_Homo sapiens_hsa051310.48643648
144T cell receptor signaling pathway_Homo sapiens_hsa046600.48579790
145Alcoholism_Homo sapiens_hsa050340.48130407
146Acute myeloid leukemia_Homo sapiens_hsa052210.47285409
147Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.46778952
148Long-term depression_Homo sapiens_hsa047300.46622509
149Long-term potentiation_Homo sapiens_hsa047200.46444664
150One carbon pool by folate_Homo sapiens_hsa006700.45223899
151Fatty acid degradation_Homo sapiens_hsa000710.44890368
152Steroid hormone biosynthesis_Homo sapiens_hsa001400.43801880
153Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.40035291
154Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.39662399
155Vascular smooth muscle contraction_Homo sapiens_hsa042700.38482444
156Lysine degradation_Homo sapiens_hsa003100.36759850
157Melanogenesis_Homo sapiens_hsa049160.34687818
158Aldosterone synthesis and secretion_Homo sapiens_hsa049250.34322907
159Dopaminergic synapse_Homo sapiens_hsa047280.34297600
160Retinol metabolism_Homo sapiens_hsa008300.34269084
161cGMP-PKG signaling pathway_Homo sapiens_hsa040220.33542539
162Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.32450628

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