NANOS3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1gonadal mesoderm development (GO:0007506)6.89288488
2negative regulation of meiosis (GO:0045835)5.95086879
3positive regulation of meiosis (GO:0045836)5.81015859
4ribosomal small subunit assembly (GO:0000028)5.59969365
5maturation of SSU-rRNA (GO:0030490)5.49303376
6positive regulation of meiotic cell cycle (GO:0051446)5.34992547
7synapsis (GO:0007129)5.31873763
8DNA deamination (GO:0045006)5.24811574
9male meiosis I (GO:0007141)5.16211279
10viral transcription (GO:0019083)4.77269371
11translational termination (GO:0006415)4.69295543
12ribosomal small subunit biogenesis (GO:0042274)4.48228156
13seminiferous tubule development (GO:0072520)4.47328498
14exploration behavior (GO:0035640)4.45809071
15DNA methylation involved in gamete generation (GO:0043046)4.43446971
16ribosome biogenesis (GO:0042254)4.40707574
17negative regulation of appetite (GO:0032099)4.40612050
18negative regulation of response to food (GO:0032096)4.40612050
19somatic hypermutation of immunoglobulin genes (GO:0016446)4.29611885
20somatic diversification of immune receptors via somatic mutation (GO:0002566)4.29611885
21resolution of meiotic recombination intermediates (GO:0000712)4.27912631
22ribonucleoprotein complex biogenesis (GO:0022613)4.24672681
23male meiosis (GO:0007140)4.19356380
24translational elongation (GO:0006414)4.15518794
25negative regulation of meiotic cell cycle (GO:0051447)4.00690881
26sister chromatid cohesion (GO:0007062)3.99476268
27dosage compensation (GO:0007549)3.98178275
28nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.96864651
29ubiquinone biosynthetic process (GO:0006744)3.94939028
30translational initiation (GO:0006413)3.94103721
31meiosis I (GO:0007127)3.90909701
32protein neddylation (GO:0045116)3.90260782
33parturition (GO:0007567)3.87781393
34ribosomal large subunit biogenesis (GO:0042273)3.87492027
35folic acid transport (GO:0015884)3.87276107
36behavioral response to nicotine (GO:0035095)3.85277550
37SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.81929932
38nucleobase biosynthetic process (GO:0046112)3.80644592
39response to pheromone (GO:0019236)3.77043949
40regulation of meiosis (GO:0040020)3.73987804
41chromosome organization involved in meiosis (GO:0070192)3.73650074
42cotranslational protein targeting to membrane (GO:0006613)3.72423360
43purine nucleobase biosynthetic process (GO:0009113)3.70836268
44protein targeting to ER (GO:0045047)3.69108828
45cellular protein complex disassembly (GO:0043624)3.67432930
46histone arginine methylation (GO:0034969)3.66457470
47DNA replication initiation (GO:0006270)3.64036865
48mitotic metaphase plate congression (GO:0007080)3.63671793
49IMP biosynthetic process (GO:0006188)3.61085408
50deoxyribose phosphate catabolic process (GO:0046386)3.59498496
51termination of RNA polymerase III transcription (GO:0006386)3.57906303
52transcription elongation from RNA polymerase III promoter (GO:0006385)3.57906303
53synaptic vesicle maturation (GO:0016188)3.57853021
54proteasome assembly (GO:0043248)3.56559367
55kinetochore assembly (GO:0051382)3.56402243
56protein complex disassembly (GO:0043241)3.53618765
57rRNA modification (GO:0000154)3.53404534
58formation of translation preinitiation complex (GO:0001731)3.52766743
59deoxyribonucleotide catabolic process (GO:0009264)3.51208544
60viral life cycle (GO:0019058)3.50234073
61ubiquinone metabolic process (GO:0006743)3.50026944
62protein-cofactor linkage (GO:0018065)3.49970185
63rRNA processing (GO:0006364)3.49830150
64establishment of protein localization to endoplasmic reticulum (GO:0072599)3.49101303
65protein localization to endoplasmic reticulum (GO:0070972)3.48439649
66establishment of mitochondrion localization (GO:0051654)3.47082316
67synaptic vesicle exocytosis (GO:0016079)3.44712547
68rRNA metabolic process (GO:0016072)3.43034546
69peptidyl-arginine omega-N-methylation (GO:0035247)3.38133553
70kinetochore organization (GO:0051383)3.37088346
71DNA strand elongation involved in DNA replication (GO:0006271)3.36150315
72macromolecular complex disassembly (GO:0032984)3.35553209
73positive regulation of mitochondrial fission (GO:0090141)3.35451238
74regulation of meiotic cell cycle (GO:0051445)3.34828273
75mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.33636731
76mitochondrial respiratory chain complex I assembly (GO:0032981)3.33636731
77NADH dehydrogenase complex assembly (GO:0010257)3.33636731
78pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.33266080
79telomere maintenance via semi-conservative replication (GO:0032201)3.32719922
80regulation of nuclear cell cycle DNA replication (GO:0033262)3.31755583
81meiotic nuclear division (GO:0007126)3.30199269
82lymphangiogenesis (GO:0001946)3.30121101
83purine deoxyribonucleotide catabolic process (GO:0009155)3.28886309
84nuclear-transcribed mRNA catabolic process (GO:0000956)3.28273102
85cellular component biogenesis (GO:0044085)3.27363529
86DNA replication checkpoint (GO:0000076)3.25996967
87attachment of spindle microtubules to kinetochore (GO:0008608)3.24661812
88pseudouridine synthesis (GO:0001522)3.23771960
89protein localization to kinetochore (GO:0034501)3.22929404
90negative regulation of heart rate (GO:0010459)3.22236971
91DNA strand elongation (GO:0022616)3.21579205
92deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.20911283
93negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.20677893
94meiotic chromosome segregation (GO:0045132)3.20403027
95regulation of transcription from RNA polymerase I promoter (GO:0006356)3.19428746
96histone H2A acetylation (GO:0043968)3.19265491
97synaptonemal complex assembly (GO:0007130)3.19072190
98translation (GO:0006412)3.18645336
99regulation of response to food (GO:0032095)3.16480445
100ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.15905098
101histone H4-K12 acetylation (GO:0043983)3.12869480
102spliceosomal snRNP assembly (GO:0000387)3.12397097
103negative regulation of gene silencing (GO:0060969)3.12247361
104positive regulation of cAMP-mediated signaling (GO:0043950)3.12222256
105anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.11554732
106CENP-A containing nucleosome assembly (GO:0034080)3.11470244
107urogenital system development (GO:0001655)3.10549882
108negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.10388865
109peptidyl-histidine modification (GO:0018202)3.09805117
110mRNA catabolic process (GO:0006402)3.09158834
111regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.08185549
112positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.07564691
113RNA catabolic process (GO:0006401)3.06752904
114establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.06064690
115mitochondrion transport along microtubule (GO:0047497)3.06064690
116mitotic spindle assembly checkpoint (GO:0007094)3.05262540
117base-excision repair, AP site formation (GO:0006285)3.04350951
118quinone biosynthetic process (GO:1901663)3.02884334
119metaphase plate congression (GO:0051310)3.02534307
120rRNA methylation (GO:0031167)3.01934070
121* oogenesis (GO:0048477)3.00816957
122transcription-coupled nucleotide-excision repair (GO:0006283)2.99471389
123protein-DNA complex disassembly (GO:0032986)2.98733145
124nucleosome disassembly (GO:0006337)2.98733145
125negative regulation of DNA-dependent DNA replication (GO:2000104)2.97800278
126synaptonemal complex organization (GO:0070193)2.97672868
127telomere maintenance via telomere lengthening (GO:0010833)2.97202376
128IMP metabolic process (GO:0046040)2.97113854
129negative regulation of chromosome segregation (GO:0051985)2.97105825
130negative regulation of mitotic sister chromatid separation (GO:2000816)2.96661506
131negative regulation of mitotic sister chromatid segregation (GO:0033048)2.96661506
132negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.96661506
133negative regulation of sister chromatid segregation (GO:0033046)2.96661506
134spindle assembly checkpoint (GO:0071173)2.96011700
135spliceosomal complex assembly (GO:0000245)2.95609351
136ncRNA processing (GO:0034470)2.95160438
137inner cell mass cell proliferation (GO:0001833)2.93306132
138ribosome assembly (GO:0042255)2.93009062
139regulation of double-strand break repair via homologous recombination (GO:0010569)2.92167335
140viral mRNA export from host cell nucleus (GO:0046784)2.91819231
141intra-S DNA damage checkpoint (GO:0031573)2.91365503
142mitotic sister chromatid cohesion (GO:0007064)2.91083986
143ncRNA metabolic process (GO:0034660)2.90503661
144ncRNA 3-end processing (GO:0043628)2.90249233
145chromatin remodeling at centromere (GO:0031055)2.89194298
146mitotic spindle checkpoint (GO:0071174)2.89063484
147mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.88657494
148regulation of posttranscriptional gene silencing (GO:0060147)2.87994698
149regulation of gene silencing by miRNA (GO:0060964)2.87994698
150regulation of gene silencing by RNA (GO:0060966)2.87994698
151metallo-sulfur cluster assembly (GO:0031163)2.86799293
152iron-sulfur cluster assembly (GO:0016226)2.86799293
153meiotic cell cycle process (GO:1903046)2.86620725
154regulation of female receptivity (GO:0045924)2.86490879
155negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.85903167
156cullin deneddylation (GO:0010388)2.85181933
157negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.83389724
158piRNA metabolic process (GO:0034587)2.82742346
159germ cell migration (GO:0008354)2.82711785
160regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.81828695
161sex differentiation (GO:0007548)2.81672085
162negative regulation of RNA splicing (GO:0033119)2.81183615
163transcription from RNA polymerase I promoter (GO:0006360)2.80912042
164snRNA processing (GO:0016180)2.80300930
165DNA unwinding involved in DNA replication (GO:0006268)2.80015343
166negative regulation of ligase activity (GO:0051352)2.79004542
167regulation of DNA endoreduplication (GO:0032875)2.76465849
168C4-dicarboxylate transport (GO:0015740)2.72883945
169telomere maintenance via recombination (GO:0000722)2.70932554
170sleep (GO:0030431)2.70091027
171negative regulation of DNA-templated transcription, elongation (GO:0032785)2.70081904
172nucleotide-excision repair, DNA gap filling (GO:0006297)2.68979988
173female mating behavior (GO:0060180)2.66447880
174mismatch repair (GO:0006298)2.66126777
175protein complex biogenesis (GO:0070271)2.65269982
176tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.65216708
177RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.65216708
178meiotic cell cycle (GO:0051321)2.63601810
179reciprocal DNA recombination (GO:0035825)2.62103884
180reciprocal meiotic recombination (GO:0007131)2.62103884
181pyrimidine nucleotide catabolic process (GO:0006244)2.62055989
182regulation of protein kinase A signaling (GO:0010738)2.62020325
183regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.61854860
184centriole replication (GO:0007099)2.61666162
185nucleotide transmembrane transport (GO:1901679)2.61623976
186deoxyribose phosphate metabolic process (GO:0019692)2.59922956
187positive regulation of prostaglandin secretion (GO:0032308)2.59568297
188positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.58304134
189chaperone-mediated protein transport (GO:0072321)2.55876723
190regulation of meiosis I (GO:0060631)10.0208649

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.88207137
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.76584884
3IGF1R_20145208_ChIP-Seq_DFB_Human3.92386936
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.54595298
5HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.39921336
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.31191007
7EZH2_22144423_ChIP-Seq_EOC_Human3.21777492
8ZNF274_21170338_ChIP-Seq_K562_Hela3.17346386
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.08461201
10MYC_18358816_ChIP-ChIP_MESCs_Mouse3.08280556
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.98081697
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.97500475
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.96570434
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.89043267
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.76368749
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.70284233
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.65067323
18XRN2_22483619_ChIP-Seq_HELA_Human2.61193778
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.51260832
20THAP11_20581084_ChIP-Seq_MESCs_Mouse2.42549547
21FOXM1_23109430_ChIP-Seq_U2OS_Human2.42350127
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.36841832
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.33051052
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.30030753
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.29766564
26CREB1_15753290_ChIP-ChIP_HEK293T_Human2.27620951
27POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.19326304
28E2F1_18555785_ChIP-Seq_MESCs_Mouse2.18555684
29IRF1_19129219_ChIP-ChIP_H3396_Human2.16605899
30DCP1A_22483619_ChIP-Seq_HELA_Human2.08982252
31VDR_23849224_ChIP-Seq_CD4+_Human2.08955198
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.06354041
33GABP_19822575_ChIP-Seq_HepG2_Human2.02413648
34YY1_21170310_ChIP-Seq_MESCs_Mouse1.99889654
35SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.99736521
36MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.98084292
37TTF2_22483619_ChIP-Seq_HELA_Human1.91466757
38NANOG_18555785_ChIP-Seq_MESCs_Mouse1.86771048
39CIITA_25753668_ChIP-Seq_RAJI_Human1.83837712
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82428445
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.81646775
42SOX2_18555785_ChIP-Seq_MESCs_Mouse1.81415247
43POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.80667812
44MYCN_18555785_ChIP-Seq_MESCs_Mouse1.80431777
45SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.78580802
46REST_21632747_ChIP-Seq_MESCs_Mouse1.77599796
47POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.76031268
48NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.75146039
49ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.74451159
50YY1_22570637_ChIP-Seq_MALME-3M_Human1.73493987
51VDR_22108803_ChIP-Seq_LS180_Human1.72510068
52ZFX_18555785_ChIP-Seq_MESCs_Mouse1.71981091
53TP63_19390658_ChIP-ChIP_HaCaT_Human1.69843891
54CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.66368467
55FOXP3_21729870_ChIP-Seq_TREG_Human1.64554391
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.64168955
57YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63674237
58SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.61628748
59* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.60744067
60MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.59597485
61REST_18959480_ChIP-ChIP_MESCs_Mouse1.59277686
62KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.58897010
63KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.58897010
64KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.58897010
65NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.57409348
66CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.55109873
67FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.51382853
68E2F1_21310950_ChIP-Seq_MCF-7_Human1.50565200
69MYC_22102868_ChIP-Seq_BL_Human1.50292852
70* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.50151594
71BCL6_27268052_Chip-Seq_Bcells_Human1.47724568
72ELF1_17652178_ChIP-ChIP_JURKAT_Human1.47714344
73RBPJ_22232070_ChIP-Seq_NCS_Mouse1.47325816
74CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.45141976
75STAT3_1855785_ChIP-Seq_MESCs_Mouse1.44693730
76SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.43712322
77KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.39463121
78EGR1_19374776_ChIP-ChIP_THP-1_Human1.36005828
79SRF_21415370_ChIP-Seq_HL-1_Mouse1.34909846
80TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33633131
81* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.33560329
82* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.33447434
83TP53_22573176_ChIP-Seq_HFKS_Human1.32615414
84FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.32349109
85PHF8_20622854_ChIP-Seq_HELA_Human1.31545171
86HOXB4_20404135_ChIP-ChIP_EML_Mouse1.29795415
87ELF1_20517297_ChIP-Seq_JURKAT_Human1.27441821
88KLF4_18555785_ChIP-Seq_MESCs_Mouse1.25945627
89CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.25874055
90* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.25721210
91ERA_21632823_ChIP-Seq_H3396_Human1.25652961
92AR_21909140_ChIP-Seq_LNCAP_Human1.25214637
93SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.23666566
94KDM5A_27292631_Chip-Seq_BREAST_Human1.23253027
95ZNF263_19887448_ChIP-Seq_K562_Human1.22343205
96EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.20327133
97FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.19103617
98SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18104419
99P68_20966046_ChIP-Seq_HELA_Human1.17395647
100FOXH1_21741376_ChIP-Seq_EPCs_Human1.16859063
101CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.14154327
102DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.13830741
103CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.13719964
104CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.13037102
105ERG_20887958_ChIP-Seq_HPC-7_Mouse1.12801648
106CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.12602625
107SOX2_18692474_ChIP-Seq_MEFs_Mouse1.11385270
108GATA3_21878914_ChIP-Seq_MCF-7_Human1.10874227
109OCT4_19829295_ChIP-Seq_ESCs_Human1.10008601
110* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.09514496
111E2F1_17053090_ChIP-ChIP_MCF-7_Human1.09405351
112* FOXP1_21924763_ChIP-Seq_HESCs_Human1.08582872
113NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.08488642
114GATA1_26923725_Chip-Seq_HPCs_Mouse1.08409497
115E2F1_20622854_ChIP-Seq_HELA_Human1.07427428
116ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.07305517
117PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.07179666
118HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.06825993
119NANOG_20526341_ChIP-Seq_ESCs_Human1.06491214
120BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.06307591
121ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.05073261
122ELK1_19687146_ChIP-ChIP_HELA_Human1.04903262
123PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.04595972
124E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04462026
125WDR5_24793694_ChIP-Seq_LNCAP_Human1.04422994
126* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.03439313
127SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.03375770
128TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.03173567
129ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.02667390
130OCT4_18692474_ChIP-Seq_MEFs_Mouse1.01951274
131* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.00135770
132HOXB7_26014856_ChIP-Seq_BT474_Human0.99571561
133TCF3_18692474_ChIP-Seq_MEFs_Mouse0.99243840
134ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.99146990
135CTBP1_25329375_ChIP-Seq_LNCAP_Human0.99095015
136SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.98801683
137MYC_19829295_ChIP-Seq_ESCs_Human0.98293866
138CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.98208800
139* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.97967955
140CTCF_18555785_ChIP-Seq_MESCs_Mouse0.97619515
141EWS_26573619_Chip-Seq_HEK293_Human0.97204001
142EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.96572297
143RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.96347799
144PADI4_21655091_ChIP-ChIP_MCF-7_Human0.95616497
145RXRA_24833708_ChIP-Seq_LIVER_Mouse0.95516211
146PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95158153
147TAF15_26573619_Chip-Seq_HEK293_Human0.94630790
148BCOR_27268052_Chip-Seq_Bcells_Human0.93598833
149RNF2_27304074_Chip-Seq_NSC_Mouse0.92205246
150RAC3_21632823_ChIP-Seq_H3396_Human0.91180986
151P300_27268052_Chip-Seq_Bcells_Human0.90452928
152VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.90033164
153CTCF_27219007_Chip-Seq_Bcells_Human0.89096005
154FOXA1_27270436_Chip-Seq_PROSTATE_Human0.86696020
155FOXA1_25329375_ChIP-Seq_VCAP_Human0.86696020
156GATA3_21867929_ChIP-Seq_CD8_Mouse0.85666541
157SOX2_22085726_ChIP-Seq_NPCs_Mouse0.84071080

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.84741929
2MP0010368_abnormal_lymphatic_system4.66573272
3MP0008995_early_reproductive_senescence4.10488338
4MP0010094_abnormal_chromosome_stability3.47202269
5MP0003111_abnormal_nucleus_morphology3.30446575
6MP0004957_abnormal_blastocyst_morpholog3.26820711
7MP0004147_increased_porphyrin_level3.13457110
8MP0003786_premature_aging3.11631443
9MP0008058_abnormal_DNA_repair3.11302133
10MP0003077_abnormal_cell_cycle3.09853370
11MP0004859_abnormal_synaptic_plasticity2.99989760
12MP0003123_paternal_imprinting2.93574266
13MP0003787_abnormal_imprinting2.79104208
14MP0000013_abnormal_adipose_tissue2.75446566
15MP0003315_abnormal_perineum_morphology2.71134578
16MP0003880_abnormal_central_pattern2.61050793
17MP0005646_abnormal_pituitary_gland2.58639176
18MP0003121_genomic_imprinting2.52587122
19MP0008877_abnormal_DNA_methylation2.41513976
20MP0008057_abnormal_DNA_replication2.40158783
21MP0003183_abnormal_peptide_metabolism2.32141543
22MP0008007_abnormal_cellular_replicative2.31158954
23MP0002272_abnormal_nervous_system2.28575511
24MP0003122_maternal_imprinting2.24783076
25MP0006292_abnormal_olfactory_placode2.23273879
26MP0008932_abnormal_embryonic_tissue2.18245903
27MP0001879_abnormal_lymphatic_vessel2.09703112
28MP0010030_abnormal_orbit_morphology2.01522511
29MP0001968_abnormal_touch/_nociception2.01412244
30MP0003635_abnormal_synaptic_transmissio2.00359455
31MP0001730_embryonic_growth_arrest2.00290431
32MP0009745_abnormal_behavioral_response1.99390640
33MP0002064_seizures1.93413009
34MP0004270_analgesia1.90719111
35MP0002396_abnormal_hematopoietic_system1.88611758
36MP0000350_abnormal_cell_proliferation1.87497999
37* MP0002210_abnormal_sex_determination1.81206785
38MP0005670_abnormal_white_adipose1.78243785
39MP0003119_abnormal_digestive_system1.74514575
40MP0002736_abnormal_nociception_after1.72572500
41MP0000516_abnormal_urinary_system1.71560643
42MP0005367_renal/urinary_system_phenotyp1.71560643
43MP0004133_heterotaxia1.67494875
44MP0009780_abnormal_chondrocyte_physiolo1.65792644
45MP0002734_abnormal_mechanical_nocicepti1.61441698
46MP0005423_abnormal_somatic_nervous1.60689105
47MP0002063_abnormal_learning/memory/cond1.57051690
48MP0001697_abnormal_embryo_size1.56283128
49MP0009046_muscle_twitch1.52295266
50MP0001177_atelectasis1.50327692
51MP0005084_abnormal_gallbladder_morpholo1.49143727
52* MP0001145_abnormal_male_reproductive1.48634846
53MP0004885_abnormal_endolymph1.47041045
54MP0002572_abnormal_emotion/affect_behav1.45993046
55MP0002735_abnormal_chemical_nociception1.45869683
56MP0002751_abnormal_autonomic_nervous1.45822288
57MP0006072_abnormal_retinal_apoptosis1.45654929
58MP0002085_abnormal_embryonic_tissue1.45011789
59MP0005551_abnormal_eye_electrophysiolog1.42301116
60MP0001986_abnormal_taste_sensitivity1.39968145
61MP0000049_abnormal_middle_ear1.39916686
62MP0009379_abnormal_foot_pigmentation1.38852347
63MP0004197_abnormal_fetal_growth/weight/1.36862780
64MP0002249_abnormal_larynx_morphology1.36499013
65MP0005167_abnormal_blood-brain_barrier1.36496956
66MP0001970_abnormal_pain_threshold1.36316072
67* MP0001929_abnormal_gametogenesis1.35102402
68MP0000490_abnormal_crypts_of1.35023491
69MP0001672_abnormal_embryogenesis/_devel1.33193016
70MP0005380_embryogenesis_phenotype1.33193016
71MP0001849_ear_inflammation1.32441606
72MP0010352_gastrointestinal_tract_polyps1.30444105
73* MP0000653_abnormal_sex_gland1.28810656
74MP0005174_abnormal_tail_pigmentation1.28352390
75MP0003646_muscle_fatigue1.25650014
76MP0002080_prenatal_lethality1.24509035
77MP0002557_abnormal_social/conspecific_i1.22774187
78MP0002084_abnormal_developmental_patter1.21502479
79MP0003984_embryonic_growth_retardation1.21330970
80MP0003890_abnormal_embryonic-extraembry1.20875591
81MP0004808_abnormal_hematopoietic_stem1.20801492
82MP0002088_abnormal_embryonic_growth/wei1.20169602
83MP0002638_abnormal_pupillary_reflex1.19788836
84MP0000313_abnormal_cell_death1.18457157
85MP0000537_abnormal_urethra_morphology1.17854960
86MP0002733_abnormal_thermal_nociception1.16815314
87MP0006036_abnormal_mitochondrial_physio1.15891000
88MP0001188_hyperpigmentation1.15531296
89MP0001293_anophthalmia1.14804558
90MP0001545_abnormal_hematopoietic_system1.10595041
91MP0005397_hematopoietic_system_phenotyp1.10595041
92MP0002938_white_spotting1.10109927
93MP0003567_abnormal_fetal_cardiomyocyte1.09453433
94MP0005075_abnormal_melanosome_morpholog1.08906637
95MP0008872_abnormal_physiological_respon1.06300959
96MP0000358_abnormal_cell_content/1.06091442
97MP0001486_abnormal_startle_reflex1.06084289
98MP0004130_abnormal_muscle_cell1.04834488
99MP0002086_abnormal_extraembryonic_tissu1.04824023
100MP0001905_abnormal_dopamine_level1.01949752
101MP0004142_abnormal_muscle_tone1.01759340
102MP0008789_abnormal_olfactory_epithelium1.01714068
103MP0002653_abnormal_ependyma_morphology1.01549014
104* MP0003698_abnormal_male_reproductive1.01030623
105MP0001485_abnormal_pinna_reflex1.00691777
106MP0002837_dystrophic_cardiac_calcinosis1.00278028
107MP0003718_maternal_effect0.99050045
108MP0002019_abnormal_tumor_incidence0.97849876
109MP0003938_abnormal_ear_development0.97553152
110MP0003861_abnormal_nervous_system0.97530240
111* MP0001119_abnormal_female_reproductive0.97437069
112MP0002882_abnormal_neuron_morphology0.97266481
113MP0001529_abnormal_vocalization0.96950994
114MP0006276_abnormal_autonomic_nervous0.96585189
115MP0009333_abnormal_splenocyte_physiolog0.96396876
116MP0002184_abnormal_innervation0.95890207
117MP0009053_abnormal_anal_canal0.94557956
118MP0004811_abnormal_neuron_physiology0.94139518
119MP0000015_abnormal_ear_pigmentation0.93872855
120MP0001286_abnormal_eye_development0.93348897
121MP0003942_abnormal_urinary_system0.92359325
122MP0003115_abnormal_respiratory_system0.90150982
123MP0001501_abnormal_sleep_pattern0.87865211
124MP0002095_abnormal_skin_pigmentation0.87855906
125MP0000631_abnormal_neuroendocrine_gland0.87381231
126MP0003638_abnormal_response/metabolism_0.86845099
127MP0000750_abnormal_muscle_regeneration0.86423372
128MP0000955_abnormal_spinal_cord0.86361091
129MP0001984_abnormal_olfaction0.86211069
130MP0004924_abnormal_behavior0.85876917
131MP0005386_behavior/neurological_phenoty0.85876917
132MP0002066_abnormal_motor_capabilities/c0.85701706
133MP0000681_abnormal_thyroid_gland0.85542940
134MP0001440_abnormal_grooming_behavior0.84889661
135MP0005253_abnormal_eye_physiology0.83798367
136MP0006035_abnormal_mitochondrial_morpho0.82020471
137MP0004145_abnormal_muscle_electrophysio0.80069975
138MP0002282_abnormal_trachea_morphology0.80011807
139MP0009278_abnormal_bone_marrow0.79290775
140MP0005645_abnormal_hypothalamus_physiol0.77911389
141MP0003186_abnormal_redox_activity0.77851672
142MP0004215_abnormal_myocardial_fiber0.76165310
143MP0000534_abnormal_ureter_morphology0.76117992
144MP0003936_abnormal_reproductive_system0.75016090
145MP0000778_abnormal_nervous_system0.74873031
146MP0005409_darkened_coat_color0.74821757
147MP0002160_abnormal_reproductive_system0.74164114
148MP0005499_abnormal_olfactory_system0.74107822
149MP0005394_taste/olfaction_phenotype0.74107822
150* MP0002161_abnormal_fertility/fecundity0.72756017
151MP0001764_abnormal_homeostasis0.72289750
152MP0001963_abnormal_hearing_physiology0.71668286
153MP0002102_abnormal_ear_morphology0.71191225
154MP0000003_abnormal_adipose_tissue0.71104685
155MP0010386_abnormal_urinary_bladder0.70840440
156MP0008569_lethality_at_weaning0.70310143
157MP0005384_cellular_phenotype0.69891689
158MP0008770_decreased_survivor_rate0.69215439
159MP0003221_abnormal_cardiomyocyte_apopto0.67270498
160MP0005389_reproductive_system_phenotype0.60855513
161MP0002081_perinatal_lethality0.57680993
162MP0005266_abnormal_metabolism0.57570284

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.79420125
2Abnormality of cells of the erythroid lineage (HP:0012130)4.55426906
3Abnormal number of erythroid precursors (HP:0012131)4.26347732
4Carpal bone hypoplasia (HP:0001498)4.19466099
5Stenosis of the external auditory canal (HP:0000402)4.05465361
6Breast hypoplasia (HP:0003187)4.03293626
7Abnormality of the anterior horn cell (HP:0006802)4.01138183
8Degeneration of anterior horn cells (HP:0002398)4.01138183
9Birth length less than 3rd percentile (HP:0003561)3.86821795
10Type II lissencephaly (HP:0007260)3.80687303
11Aplastic anemia (HP:0001915)3.69781966
12Impulsivity (HP:0100710)3.64795537
13Cerebral hypomyelination (HP:0006808)3.57796084
14Increased hepatocellular lipid droplets (HP:0006565)3.55561597
15Absent thumb (HP:0009777)3.55487420
16Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.49450781
17Patellar aplasia (HP:0006443)3.42097318
18Abnormality of the labia minora (HP:0012880)3.38665630
19Lipid accumulation in hepatocytes (HP:0006561)3.32003648
20Acute necrotizing encephalopathy (HP:0006965)3.26820203
21Abnormality of the renal collecting system (HP:0004742)3.25473073
22Oral leukoplakia (HP:0002745)3.23061578
23Aplasia/Hypoplasia of the patella (HP:0006498)3.21707487
24Mitochondrial inheritance (HP:0001427)3.20703026
25Acute encephalopathy (HP:0006846)3.18538181
26Abnormal hemoglobin (HP:0011902)3.17535428
27Horseshoe kidney (HP:0000085)3.07903517
28Abnormality of the costochondral junction (HP:0000919)3.03132327
29Increased CSF lactate (HP:0002490)2.99300656
30Rectal fistula (HP:0100590)2.99179711
31Rectovaginal fistula (HP:0000143)2.99179711
32Supernumerary spleens (HP:0009799)2.92648824
33Macrocytic anemia (HP:0001972)2.91389237
34Abnormality of the corticospinal tract (HP:0002492)2.91234617
35Colon cancer (HP:0003003)2.88752369
36Failure to thrive in infancy (HP:0001531)2.84294073
37Hyperglycinuria (HP:0003108)2.84254355
38Volvulus (HP:0002580)2.84180386
39Progressive macrocephaly (HP:0004481)2.83903857
40Retinal dysplasia (HP:0007973)2.83223951
41Abnormal mitochondria in muscle tissue (HP:0008316)2.82094712
42Tongue fasciculations (HP:0001308)2.80564118
43Molar tooth sign on MRI (HP:0002419)2.78324664
44Abnormality of midbrain morphology (HP:0002418)2.78324664
45Agnosia (HP:0010524)2.78004019
46Amyotrophic lateral sclerosis (HP:0007354)2.74518137
47Nephronophthisis (HP:0000090)2.72279587
48Aplasia/Hypoplasia of the spleen (HP:0010451)2.72176429
49Degeneration of the lateral corticospinal tracts (HP:0002314)2.72051037
50Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.72051037
51Ectopic kidney (HP:0000086)2.71772085
52Pallor (HP:0000980)2.69262422
53Rough bone trabeculation (HP:0100670)2.68234076
54Myokymia (HP:0002411)2.65006047
55Renal Fanconi syndrome (HP:0001994)2.62303540
56Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.61876421
57Decreased activity of mitochondrial respiratory chain (HP:0008972)2.61876421
58Absent radius (HP:0003974)2.58944040
59Vaginal fistula (HP:0004320)2.57737386
60Asplenia (HP:0001746)2.56538846
61Hepatocellular necrosis (HP:0001404)2.56402340
62Muscle fiber atrophy (HP:0100295)2.54766239
63Intestinal fistula (HP:0100819)2.52006764
64Type 2 muscle fiber atrophy (HP:0003554)2.50679719
65Abnormality of the ileum (HP:0001549)2.49793098
66Optic nerve coloboma (HP:0000588)2.48639586
67Aplasia involving forearm bones (HP:0009822)2.48362925
68Absent forearm bone (HP:0003953)2.48362925
69Meckel diverticulum (HP:0002245)2.48220917
70Chromosomal breakage induced by crosslinking agents (HP:0003221)2.46776351
71Aplasia/Hypoplasia involving the musculature (HP:0001460)2.44576687
72Shawl scrotum (HP:0000049)2.42882810
73Selective tooth agenesis (HP:0001592)2.42494737
74Renal duplication (HP:0000075)2.41413610
75Split foot (HP:0001839)2.41225993
76Hepatic necrosis (HP:0002605)2.40296164
77Atrophy/Degeneration involving motor neurons (HP:0007373)2.38968772
78Muscle fibrillation (HP:0010546)2.38695672
79Cerebellar dysplasia (HP:0007033)2.38626787
80Abnormality of DNA repair (HP:0003254)2.36653535
81Aplasia/hypoplasia of the humerus (HP:0006507)2.36546430
82Chromsome breakage (HP:0040012)2.35697004
83Triphalangeal thumb (HP:0001199)2.35191863
84Cerebral edema (HP:0002181)2.34495499
85Delayed epiphyseal ossification (HP:0002663)2.32320768
86Ependymoma (HP:0002888)2.31970184
87Osteomalacia (HP:0002749)2.29599500
88Mesangial abnormality (HP:0001966)2.28794245
89Polyphagia (HP:0002591)2.26536867
90Progressive microcephaly (HP:0000253)2.26468229
91Opisthotonus (HP:0002179)2.25595868
92Anal stenosis (HP:0002025)2.25028120
93Increased intramyocellular lipid droplets (HP:0012240)2.23760992
94CNS hypomyelination (HP:0003429)2.22286707
95Pachygyria (HP:0001302)2.19259112
96Spinal muscular atrophy (HP:0007269)2.17962355
97Myelodysplasia (HP:0002863)2.17903965
98Pancreatic fibrosis (HP:0100732)2.17747844
99Microvesicular hepatic steatosis (HP:0001414)2.17543497
100Abnormality of the lower motor neuron (HP:0002366)2.15365539
101Pancreatic cysts (HP:0001737)2.14468640
102Hypoplasia of the radius (HP:0002984)2.14407511
103Rib fusion (HP:0000902)2.12970902
104Scotoma (HP:0000575)2.12462418
105Tachypnea (HP:0002789)2.11392725
106Bone marrow hypocellularity (HP:0005528)2.11051543
107Spastic gait (HP:0002064)2.05247013
108Urinary urgency (HP:0000012)2.04398473
109Abnormality of the preputium (HP:0100587)2.03248989
110Pancytopenia (HP:0001876)2.02859163
111Premature graying of hair (HP:0002216)2.01627332
112Tracheoesophageal fistula (HP:0002575)2.01048742
113Visual hallucinations (HP:0002367)2.00071407
114Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.99548339
115Premature ovarian failure (HP:0008209)1.99248193
116High anterior hairline (HP:0009890)1.99218737
117Hyperventilation (HP:0002883)1.98616757
118Aplasia/hypoplasia of the uterus (HP:0008684)1.98308146
119Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.97913315
120Lissencephaly (HP:0001339)1.97531676
121Lactic acidosis (HP:0003128)1.97193605
122Short thumb (HP:0009778)1.95491462
123Impaired vibration sensation in the lower limbs (HP:0002166)1.93938188
124Aplasia/Hypoplasia of the uvula (HP:0010293)1.93415632
125Drooling (HP:0002307)1.92196815
126Sleep apnea (HP:0010535)1.91879693
127Short tibia (HP:0005736)1.90729848
128Neoplasm of the pancreas (HP:0002894)1.90425704
129Small hand (HP:0200055)1.90122499
130Short humerus (HP:0005792)1.89896205
131Upper motor neuron abnormality (HP:0002127)1.89374813
13211 pairs of ribs (HP:0000878)1.89058293
133Severe muscular hypotonia (HP:0006829)1.88745893
134Abnormality of lateral ventricle (HP:0030047)1.87799631
135Abnormal trabecular bone morphology (HP:0100671)1.87755388
136Respiratory difficulties (HP:0002880)1.87593853
137Aplasia/Hypoplasia of the brainstem (HP:0007362)1.87521434
138Hypoplasia of the brainstem (HP:0002365)1.87521434
139Delayed CNS myelination (HP:0002188)1.86122297
140Hypochromic microcytic anemia (HP:0004840)1.86036413
141Increased muscle lipid content (HP:0009058)1.85389345
142Esotropia (HP:0000565)1.85378552
143Short 1st metacarpal (HP:0010034)1.84714680
144Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.84714680
145Abnormal neuron morphology (HP:0012757)1.84380003
146Abnormality of the motor neurons (HP:0002450)1.84380003
147Abnormality of chromosome stability (HP:0003220)1.84156364
148Abnormality of cochlea (HP:0000375)1.84144281
149Medial flaring of the eyebrow (HP:0010747)1.84009623
150Abnormality of serine family amino acid metabolism (HP:0010894)1.82768429
151Abnormality of glycine metabolism (HP:0010895)1.82768429
152Oligomenorrhea (HP:0000876)1.82616804
153Intellectual disability, profound (HP:0002187)1.82518599
154Hypercortisolism (HP:0001578)1.81980262
155Morphological abnormality of the inner ear (HP:0011390)1.81513471
156Abnormality of the renal medulla (HP:0100957)1.80004006
157Hyperglycinemia (HP:0002154)1.78952823
158Glycosuria (HP:0003076)1.78910783
159Abnormality of urine glucose concentration (HP:0011016)1.78910783
160Slender long bone (HP:0003100)1.77969671
161Medulloblastoma (HP:0002885)1.77701744
162Optic disc pallor (HP:0000543)1.77486006
163Abnormal spermatogenesis (HP:0008669)1.75977069
164Abnormal hair whorl (HP:0010721)1.75047577
165Hypoplasia of the uterus (HP:0000013)1.74205330
166Small intestinal stenosis (HP:0012848)1.73697637
167Duodenal stenosis (HP:0100867)1.73697637
168Abnormality of alanine metabolism (HP:0010916)1.73311807
169Hyperalaninemia (HP:0003348)1.73311807
170Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.73311807
171Sex reversal (HP:0012245)1.72625742
172Abnormal sex determination (HP:0012244)1.72625742
173Microretrognathia (HP:0000308)1.72033047
174Multiple enchondromatosis (HP:0005701)1.70995649
175Secondary amenorrhea (HP:0000869)1.69470769
176Increased serum lactate (HP:0002151)1.69346217

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DYRK33.71324092
2WNK33.56588261
3BUB13.40479102
4STK163.36806900
5ACVR1B3.23670036
6WEE13.11694774
7EPHB22.90423898
8EIF2AK12.72050300
9NEK22.61110987
10TLK12.53786295
11CDK192.43943877
12PNCK2.36697489
13ZAK2.27970595
14SRPK12.23190481
15NME22.19370446
16MAP3K102.10485187
17EPHA42.10234729
18NEK12.03174814
19MKNK12.03160108
20MAP2K22.01977827
21CSNK1G21.94796010
22RPS6KB21.93043152
23MKNK21.88986066
24PLK21.82611931
25CDK71.81186274
26DYRK21.81120235
27MAP3K41.78701485
28TESK21.78520579
29PLK11.75204083
30MAP4K21.66787261
31TNK21.65187526
32KIT1.63654540
33VRK11.61962463
34PASK1.54619441
35RPS6KA41.52170159
36CDC71.50761122
37ATR1.49122434
38CDK121.46878731
39BRD41.46558713
40KSR11.43812545
41UHMK11.35535055
42EPHA21.35490594
43BRSK21.31446698
44AURKA1.27353719
45TAOK31.27300195
46CSNK1A1L1.24281933
47DAPK21.22752864
48KDR1.22339283
49PHKG21.21876022
50PHKG11.21876022
51CSNK1G11.20454526
52BRSK11.18672390
53ADRBK21.18540642
54BRAF1.18263095
55TGFBR11.16047670
56EIF2AK31.15604972
57VRK21.15571586
58PRKCG1.11375180
59PINK11.11286745
60PAK61.09565377
61DYRK1B1.08639519
62FRK1.04711397
63MAP3K91.04630314
64EEF2K1.03835043
65NTRK31.03116629
66MAP2K71.02305193
67ABL21.01513507
68CAMKK11.00196754
69BMPR1B0.99814147
70TIE10.99246960
71CASK0.96197189
72TSSK60.95855707
73WNK40.94561010
74MINK10.94523386
75SIK20.91673374
76TTK0.91416948
77AURKB0.91073212
78STK390.90625259
79SCYL20.89828419
80BCKDK0.88018409
81CCNB10.87984320
82TRIM280.87409845
83PLK30.87103865
84NME10.84947383
85PAK40.84798191
86CHEK20.84634746
87TYRO30.83196188
88MAP3K110.82553663
89OXSR10.78613080
90LIMK10.75928829
91MARK10.75145404
92MAP3K60.74611009
93BTK0.72504507
94PLK40.71754586
95MATK0.71708776
96MAP2K60.70876040
97PAK30.68562365
98MAPK40.67093202
99TESK10.67043964
100ADRBK10.66089614
101CDK20.65544990
102STK110.64940115
103ERBB20.64920638
104BCR0.64375099
105NTRK20.63532845
106DAPK10.63066176
107NUAK10.62235249
108CHEK10.60734611
109SIK30.59939663
110NEK60.59245261
111EIF2AK20.59227973
112BLK0.59125632
113CDK11A0.54633882
114DAPK30.53149013
115CSNK2A20.52585159
116GRK10.52483029
117CAMK2A0.51085618
118MAP3K80.50675674
119PIM10.49226635
120PKN10.49194563
121TNIK0.48812963
122MUSK0.48082925
123CDK40.47146592
124CSNK2A10.46280324
125PTK2B0.46189641
126CDK180.46029429
127PAK10.45552457
128MAPK90.44808689
129FLT30.44720089
130CDK50.44101633
131TAF10.43470502
132SYK0.43353373
133ATM0.42623200
134CDK80.42329347
135MAP2K30.42164010
136MAPK110.42133930
137STK38L0.41641639
138CAMK10.40904128
139CDK150.39718405
140MAPK150.38562519
141PRKACA0.38476482
142RPS6KA50.38107793
143CSNK1A10.37540658
144ERBB30.37079261
145PRKCQ0.36856074
146CDK10.36784791
147GRK50.36260749
148STK240.35500375
149CDK140.35085405
150AKT20.35011292
151TGFBR20.34879428
152RPS6KA10.34825168
153RPS6KL10.33972757
154RPS6KC10.33972757
155CDK30.32638941
156DYRK1A0.31100236
157PDK40.30745545
158PDK30.30745545
159MAPK130.28176203
160PRKCI0.26721653
161CAMKK20.25511616
162RPS6KA20.25011418
163CSNK1G30.22209077

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.75034545
2DNA replication_Homo sapiens_hsa030304.30699020
3RNA polymerase_Homo sapiens_hsa030204.22054622
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.16420267
5Spliceosome_Homo sapiens_hsa030403.53744514
6Proteasome_Homo sapiens_hsa030503.49662728
7Mismatch repair_Homo sapiens_hsa034303.38170286
8RNA transport_Homo sapiens_hsa030132.97722468
9Base excision repair_Homo sapiens_hsa034102.96591361
10Pyrimidine metabolism_Homo sapiens_hsa002402.89469122
11Nicotine addiction_Homo sapiens_hsa050332.55679001
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.51593977
13Nucleotide excision repair_Homo sapiens_hsa034202.51049829
14Cell cycle_Homo sapiens_hsa041102.45302278
15Basal transcription factors_Homo sapiens_hsa030222.44137352
16Homologous recombination_Homo sapiens_hsa034402.40358558
17mRNA surveillance pathway_Homo sapiens_hsa030152.08860488
18Fanconi anemia pathway_Homo sapiens_hsa034602.03325749
19Synaptic vesicle cycle_Homo sapiens_hsa047211.94607832
20RNA degradation_Homo sapiens_hsa030181.86179409
21Sulfur relay system_Homo sapiens_hsa041221.83169013
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.66642616
23One carbon pool by folate_Homo sapiens_hsa006701.64512209
24Purine metabolism_Homo sapiens_hsa002301.61423516
25Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.47937819
26Phototransduction_Homo sapiens_hsa047441.47597085
27SNARE interactions in vesicular transport_Homo sapiens_hsa041301.35407009
28Non-homologous end-joining_Homo sapiens_hsa034501.30609484
29Insulin secretion_Homo sapiens_hsa049111.27936688
30Huntingtons disease_Homo sapiens_hsa050161.24729024
31Morphine addiction_Homo sapiens_hsa050321.24023838
32Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.22326823
33p53 signaling pathway_Homo sapiens_hsa041151.20356483
34Parkinsons disease_Homo sapiens_hsa050121.19556519
35Collecting duct acid secretion_Homo sapiens_hsa049661.19374005
36Oocyte meiosis_Homo sapiens_hsa041141.19012238
37Selenocompound metabolism_Homo sapiens_hsa004501.12711382
38Folate biosynthesis_Homo sapiens_hsa007901.11481762
39Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.09919724
40Epstein-Barr virus infection_Homo sapiens_hsa051691.08829445
41Dorso-ventral axis formation_Homo sapiens_hsa043201.08387326
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.06812639
43Thyroid cancer_Homo sapiens_hsa052161.05215667
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.01587781
45Olfactory transduction_Homo sapiens_hsa047401.01223940
46Primary immunodeficiency_Homo sapiens_hsa053400.99450456
47GABAergic synapse_Homo sapiens_hsa047270.99070778
48Herpes simplex infection_Homo sapiens_hsa051680.96936794
49Circadian entrainment_Homo sapiens_hsa047130.95798730
50Notch signaling pathway_Homo sapiens_hsa043300.93304236
51Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.93165074
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.91789701
53Oxidative phosphorylation_Homo sapiens_hsa001900.90749039
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.78723881
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.78020338
56Cyanoamino acid metabolism_Homo sapiens_hsa004600.77127010
57Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.74750069
58Protein export_Homo sapiens_hsa030600.72767222
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71486450
60Taste transduction_Homo sapiens_hsa047420.71184252
61Salivary secretion_Homo sapiens_hsa049700.71024864
62Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.70903867
63Glycosaminoglycan degradation_Homo sapiens_hsa005310.67709080
64N-Glycan biosynthesis_Homo sapiens_hsa005100.66268718
65Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.64847187
66Fatty acid elongation_Homo sapiens_hsa000620.64329172
67Glutamatergic synapse_Homo sapiens_hsa047240.64268786
68HTLV-I infection_Homo sapiens_hsa051660.63749875
69Asthma_Homo sapiens_hsa053100.63351654
70Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61624020
71Basal cell carcinoma_Homo sapiens_hsa052170.57993699
72Calcium signaling pathway_Homo sapiens_hsa040200.57731677
73Colorectal cancer_Homo sapiens_hsa052100.54736604
74Hippo signaling pathway_Homo sapiens_hsa043900.52302856
75Rheumatoid arthritis_Homo sapiens_hsa053230.51896177
76Transcriptional misregulation in cancer_Homo sapiens_hsa052020.51552382
77Long-term depression_Homo sapiens_hsa047300.51497953
78beta-Alanine metabolism_Homo sapiens_hsa004100.51078240
79Chemical carcinogenesis_Homo sapiens_hsa052040.48707150
80Systemic lupus erythematosus_Homo sapiens_hsa053220.47684847
81Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.45780646
82Acute myeloid leukemia_Homo sapiens_hsa052210.44214491
83Tryptophan metabolism_Homo sapiens_hsa003800.43203305
84Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42588786
85Alcoholism_Homo sapiens_hsa050340.42062216
86Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.41778431
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41761261
88Dopaminergic synapse_Homo sapiens_hsa047280.41431231
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.41398661
90Biosynthesis of amino acids_Homo sapiens_hsa012300.39106986
91Viral carcinogenesis_Homo sapiens_hsa052030.37865211
92Glycerolipid metabolism_Homo sapiens_hsa005610.37498829
93Glutathione metabolism_Homo sapiens_hsa004800.37229407
94Non-small cell lung cancer_Homo sapiens_hsa052230.35577304
95Propanoate metabolism_Homo sapiens_hsa006400.35082336
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34252260
97Oxytocin signaling pathway_Homo sapiens_hsa049210.33924127
98MicroRNAs in cancer_Homo sapiens_hsa052060.33735784
99Intestinal immune network for IgA production_Homo sapiens_hsa046720.33704379
100Cholinergic synapse_Homo sapiens_hsa047250.33620975
101Alzheimers disease_Homo sapiens_hsa050100.33564922
102Butanoate metabolism_Homo sapiens_hsa006500.33294113
103ABC transporters_Homo sapiens_hsa020100.32819932
104Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.32746269
105Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.31955634
106Cardiac muscle contraction_Homo sapiens_hsa042600.31652902
107Endocytosis_Homo sapiens_hsa041440.31329393
108TGF-beta signaling pathway_Homo sapiens_hsa043500.31144519
109Amphetamine addiction_Homo sapiens_hsa050310.31141192
110Linoleic acid metabolism_Homo sapiens_hsa005910.31138984
111Wnt signaling pathway_Homo sapiens_hsa043100.30915366
112Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30541832
113Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30332454
114Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30141579
115Maturity onset diabetes of the young_Homo sapiens_hsa049500.29241241
116Metabolic pathways_Homo sapiens_hsa011000.28799398
117Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.28649017
118Fatty acid degradation_Homo sapiens_hsa000710.27423525
119Shigellosis_Homo sapiens_hsa051310.26601193
120Pathways in cancer_Homo sapiens_hsa052000.26203657
121Apoptosis_Homo sapiens_hsa042100.25511151
122Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.25184211
123Bladder cancer_Homo sapiens_hsa052190.24987883
124Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.24869677
125Hedgehog signaling pathway_Homo sapiens_hsa043400.23552659
126Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.23240956
127Small cell lung cancer_Homo sapiens_hsa052220.23200719
128RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.22868316
129Neurotrophin signaling pathway_Homo sapiens_hsa047220.22306489
130Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.21090086
131Central carbon metabolism in cancer_Homo sapiens_hsa052300.19828406
132Regulation of autophagy_Homo sapiens_hsa041400.19236548
133Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.18739632
1342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.18685107
135mTOR signaling pathway_Homo sapiens_hsa041500.18570614
136NOD-like receptor signaling pathway_Homo sapiens_hsa046210.18558475
137Type I diabetes mellitus_Homo sapiens_hsa049400.17956988
138Glycerophospholipid metabolism_Homo sapiens_hsa005640.17608838
139Pentose phosphate pathway_Homo sapiens_hsa000300.16888390
140Aldosterone synthesis and secretion_Homo sapiens_hsa049250.16372538
141HIF-1 signaling pathway_Homo sapiens_hsa040660.15511882
142Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.15149741
143Hepatitis B_Homo sapiens_hsa051610.14358159
144Thyroid hormone signaling pathway_Homo sapiens_hsa049190.13879387
145Endometrial cancer_Homo sapiens_hsa052130.11320274
146Chronic myeloid leukemia_Homo sapiens_hsa052200.11148581
147Arachidonic acid metabolism_Homo sapiens_hsa005900.10496092
148Carbon metabolism_Homo sapiens_hsa012000.10119623
149Choline metabolism in cancer_Homo sapiens_hsa052310.09027692
150Influenza A_Homo sapiens_hsa051640.08055132
151Gap junction_Homo sapiens_hsa045400.07440286
152VEGF signaling pathway_Homo sapiens_hsa043700.06897718

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