

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ribosomal small subunit assembly (GO:0000028) | 4.96675687 |
| 2 | protein K6-linked ubiquitination (GO:0085020) | 4.63177090 |
| 3 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.59611984 |
| 4 | ATP synthesis coupled proton transport (GO:0015986) | 4.29823117 |
| 5 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.29823117 |
| 6 | establishment of integrated proviral latency (GO:0075713) | 4.27952312 |
| 7 | DNA deamination (GO:0045006) | 4.17447429 |
| 8 | telomere maintenance via semi-conservative replication (GO:0032201) | 4.17317563 |
| 9 | proteasome assembly (GO:0043248) | 4.10623194 |
| 10 | dopamine transport (GO:0015872) | 4.10606333 |
| 11 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.06892784 |
| 12 | NADH dehydrogenase complex assembly (GO:0010257) | 4.03967966 |
| 13 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.03967966 |
| 14 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.03967966 |
| 15 | protoporphyrinogen IX biosynthetic process (GO:0006782) | 3.93326689 |
| 16 | protein complex biogenesis (GO:0070271) | 3.91451501 |
| 17 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.89173345 |
| 18 | DNA replication initiation (GO:0006270) | 3.88751818 |
| 19 | DNA strand elongation (GO:0022616) | 3.84300394 |
| 20 | protoporphyrinogen IX metabolic process (GO:0046501) | 3.79259564 |
| 21 | chaperone-mediated protein transport (GO:0072321) | 3.78654953 |
| 22 | DNA double-strand break processing (GO:0000729) | 3.75180092 |
| 23 | DNA replication checkpoint (GO:0000076) | 3.68685088 |
| 24 | nuclear pore organization (GO:0006999) | 3.68335294 |
| 25 | oxidative phosphorylation (GO:0006119) | 3.68142557 |
| 26 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.65645749 |
| 27 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.64494560 |
| 28 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.62410746 |
| 29 | ribosomal small subunit biogenesis (GO:0042274) | 3.61721870 |
| 30 | ribosome assembly (GO:0042255) | 3.61470420 |
| 31 | viral transcription (GO:0019083) | 3.59932649 |
| 32 | telomere maintenance via recombination (GO:0000722) | 3.57075420 |
| 33 | translational termination (GO:0006415) | 3.54269020 |
| 34 | positive regulation of protein homodimerization activity (GO:0090073) | 3.54006349 |
| 35 | regulation of DNA endoreduplication (GO:0032875) | 3.50692183 |
| 36 | cullin deneddylation (GO:0010388) | 3.49119008 |
| 37 | deoxyribose phosphate biosynthetic process (GO:0046385) | 3.49115553 |
| 38 | 2-deoxyribonucleotide biosynthetic process (GO:0009265) | 3.49115553 |
| 39 | GTP biosynthetic process (GO:0006183) | 3.49048935 |
| 40 | regulation of mitochondrial translation (GO:0070129) | 3.47621405 |
| 41 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.45923159 |
| 42 | establishment of viral latency (GO:0019043) | 3.44911792 |
| 43 | pseudouridine synthesis (GO:0001522) | 3.44155304 |
| 44 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 3.44097471 |
| 45 | isotype switching (GO:0045190) | 3.44097471 |
| 46 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 3.44097471 |
| 47 | protein deneddylation (GO:0000338) | 3.42481214 |
| 48 | CENP-A containing nucleosome assembly (GO:0034080) | 3.42289210 |
| 49 | chromatin remodeling at centromere (GO:0031055) | 3.42233720 |
| 50 | protein-cofactor linkage (GO:0018065) | 3.40190062 |
| 51 | respiratory electron transport chain (GO:0022904) | 3.39642687 |
| 52 | nuclear pore complex assembly (GO:0051292) | 3.38594014 |
| 53 | respiratory chain complex IV assembly (GO:0008535) | 3.38436014 |
| 54 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 3.36234920 |
| 55 | maturation of SSU-rRNA (GO:0030490) | 3.36141131 |
| 56 | mitotic metaphase plate congression (GO:0007080) | 3.35299101 |
| 57 | synapsis (GO:0007129) | 3.34477734 |
| 58 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.32934711 |
| 59 | deoxyribonucleotide biosynthetic process (GO:0009263) | 3.32885904 |
| 60 | electron transport chain (GO:0022900) | 3.32620219 |
| 61 | nucleobase biosynthetic process (GO:0046112) | 3.31914719 |
| 62 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.30239921 |
| 63 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.28789535 |
| 64 | DNA unwinding involved in DNA replication (GO:0006268) | 3.27003751 |
| 65 | purine nucleobase biosynthetic process (GO:0009113) | 3.26220661 |
| 66 | DNA strand renaturation (GO:0000733) | 3.25882390 |
| 67 | ribosomal large subunit biogenesis (GO:0042273) | 3.25370906 |
| 68 | maturation of 5.8S rRNA (GO:0000460) | 3.25096061 |
| 69 | mitotic recombination (GO:0006312) | 3.24565975 |
| 70 | rRNA modification (GO:0000154) | 3.23821182 |
| 71 | translational elongation (GO:0006414) | 3.23505663 |
| 72 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.22335260 |
| 73 | cotranslational protein targeting to membrane (GO:0006613) | 3.22234979 |
| 74 | inner mitochondrial membrane organization (GO:0007007) | 3.21539165 |
| 75 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.20478941 |
| 76 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.19983688 |
| 77 | heme biosynthetic process (GO:0006783) | 3.18991222 |
| 78 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.18655391 |
| 79 | pteridine-containing compound biosynthetic process (GO:0042559) | 3.17887899 |
| 80 | metaphase plate congression (GO:0051310) | 3.17407675 |
| 81 | non-recombinational repair (GO:0000726) | 3.16790920 |
| 82 | double-strand break repair via nonhomologous end joining (GO:0006303) | 3.16790920 |
| 83 | replication fork processing (GO:0031297) | 3.16748551 |
| 84 | telomere maintenance via telomere lengthening (GO:0010833) | 3.15377159 |
| 85 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.14918273 |
| 86 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.14918273 |
| 87 | IMP biosynthetic process (GO:0006188) | 3.14185235 |
| 88 | attachment of spindle microtubules to kinetochore (GO:0008608) | 3.14143158 |
| 89 | signal peptide processing (GO:0006465) | 3.14072476 |
| 90 | termination of RNA polymerase III transcription (GO:0006386) | 3.13578231 |
| 91 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.13578231 |
| 92 | oxaloacetate metabolic process (GO:0006107) | 3.13169585 |
| 93 | cellular component biogenesis (GO:0044085) | 3.12911470 |
| 94 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.12765875 |
| 95 | dolichol-linked oligosaccharide biosynthetic process (GO:0006488) | 3.12532000 |
| 96 | UTP biosynthetic process (GO:0006228) | 3.12420290 |
| 97 | protein targeting to ER (GO:0045047) | 3.12341143 |
| 98 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.12226320 |
| 99 | negative regulation of ligase activity (GO:0051352) | 3.12226320 |
| 100 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.11983277 |
| 101 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.10397895 |
| 102 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.10279023 |
| 103 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.10279023 |
| 104 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.09340989 |
| 105 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.09340989 |
| 106 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.09340989 |
| 107 | NADH metabolic process (GO:0006734) | 3.08370403 |
| 108 | spliceosomal snRNP assembly (GO:0000387) | 3.07955906 |
| 109 | protein targeting to mitochondrion (GO:0006626) | 3.05380992 |
| 110 | histone exchange (GO:0043486) | 3.05363644 |
| 111 | iron-sulfur cluster assembly (GO:0016226) | 3.04587505 |
| 112 | metallo-sulfur cluster assembly (GO:0031163) | 3.04587505 |
| 113 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.03681262 |
| 114 | 7-methylguanosine mRNA capping (GO:0006370) | 3.02882677 |
| 115 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.02467011 |
| 116 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.02141999 |
| 117 | 7-methylguanosine RNA capping (GO:0009452) | 3.00924769 |
| 118 | RNA capping (GO:0036260) | 3.00924769 |
| 119 | regulation of centriole replication (GO:0046599) | 3.00816250 |
| 120 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.00662878 |
| 121 | protein localization to endoplasmic reticulum (GO:0070972) | 3.00622424 |
| 122 | meiotic chromosome segregation (GO:0045132) | 3.00034160 |
| 123 | establishment of protein localization to mitochondrion (GO:0072655) | 2.99091273 |
| 124 | pyrimidine nucleoside triphosphate metabolic process (GO:0009147) | 2.99002339 |
| 125 | mitotic sister chromatid segregation (GO:0000070) | 2.98876284 |
| 126 | translation (GO:0006412) | 2.98468816 |
| 127 | cellular protein complex disassembly (GO:0043624) | 2.97985161 |
| 128 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 2.97309331 |
| 129 | histone mRNA metabolic process (GO:0008334) | 2.95414369 |
| 130 | mitotic sister chromatid cohesion (GO:0007064) | 2.94405742 |
| 131 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 2.91364876 |
| 132 | lactate metabolic process (GO:0006089) | 2.88582633 |
| 133 | somatic recombination of immunoglobulin gene segments (GO:0016447) | 2.87308558 |
| 134 | UDP-N-acetylglucosamine metabolic process (GO:0006047) | 2.86605359 |
| 135 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 2.85779109 |
| 136 | cell cycle G1/S phase transition (GO:0044843) | 2.84291892 |
| 137 | G1/S transition of mitotic cell cycle (GO:0000082) | 2.84291892 |
| 138 | kinetochore organization (GO:0051383) | 2.83490266 |
| 139 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 2.83037670 |
| 140 | spindle checkpoint (GO:0031577) | 2.82936885 |
| 141 | mitochondrial RNA metabolic process (GO:0000959) | 2.82741234 |
| 142 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 2.82256492 |
| 143 | DNA replication-dependent nucleosome organization (GO:0034723) | 2.79064183 |
| 144 | DNA replication-dependent nucleosome assembly (GO:0006335) | 2.79064183 |
| 145 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 2.78899200 |
| 146 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 2.78263221 |
| 147 | regulation of mitotic spindle checkpoint (GO:1903504) | 2.78263221 |
| 148 | protein localization to kinetochore (GO:0034501) | 2.78173579 |
| 149 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 2.78046506 |
| 150 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 2.78046506 |
| 151 | mitotic nuclear envelope disassembly (GO:0007077) | 2.77182639 |
| 152 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 2.76386965 |
| 153 | sister chromatid segregation (GO:0000819) | 2.76070445 |
| 154 | double-strand break repair via homologous recombination (GO:0000724) | 2.74395233 |
| 155 | recombinational repair (GO:0000725) | 2.74027474 |
| 156 | IMP metabolic process (GO:0046040) | 2.72655307 |
| 157 | positive regulation of ligase activity (GO:0051351) | 2.71504270 |
| 158 | somatic diversification of immunoglobulins (GO:0016445) | 2.69983781 |
| 159 | mitotic spindle checkpoint (GO:0071174) | 2.68658769 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 7.46284001 |
| 2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.66903986 |
| 3 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.01321767 |
| 4 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.98014123 |
| 5 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.95852456 |
| 6 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.77238320 |
| 7 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.62693212 |
| 8 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.56513426 |
| 9 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 3.34597486 |
| 10 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.34414147 |
| 11 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.20761293 |
| 12 | * HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.98455283 |
| 13 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.92993744 |
| 14 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.92541436 |
| 15 | * MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.88721836 |
| 16 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.79122503 |
| 17 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.75851552 |
| 18 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.61217977 |
| 19 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.56339932 |
| 20 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.55220861 |
| 21 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.48491774 |
| 22 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 2.46492354 |
| 23 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.42400884 |
| 24 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.40173812 |
| 25 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.30694532 |
| 26 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.30477666 |
| 27 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.27197556 |
| 28 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.20181253 |
| 29 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.17552931 |
| 30 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 2.13390612 |
| 31 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.10459132 |
| 32 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.07403266 |
| 33 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.06128411 |
| 34 | * NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.00314961 |
| 35 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.00239136 |
| 36 | * PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.94242456 |
| 37 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.94010966 |
| 38 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.90727664 |
| 39 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.85887490 |
| 40 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.85616175 |
| 41 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.84733554 |
| 42 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.83842681 |
| 43 | * HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.82766642 |
| 44 | * FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.79118908 |
| 45 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.74871503 |
| 46 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.70063346 |
| 47 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.66969952 |
| 48 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.63024670 |
| 49 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.62397083 |
| 50 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.62257962 |
| 51 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.54359404 |
| 52 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.50321429 |
| 53 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.49311241 |
| 54 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.45615052 |
| 55 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 1.44382389 |
| 56 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.44252621 |
| 57 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.42123247 |
| 58 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.40903724 |
| 59 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.38638565 |
| 60 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.35641527 |
| 61 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.34790452 |
| 62 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.33599688 |
| 63 | FUS_26573619_Chip-Seq_HEK293_Human | 1.33488522 |
| 64 | VDR_22108803_ChIP-Seq_LS180_Human | 1.30358772 |
| 65 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.30004258 |
| 66 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.27934892 |
| 67 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.26891950 |
| 68 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.25891028 |
| 69 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.24876637 |
| 70 | * POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.20348415 |
| 71 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 1.18302051 |
| 72 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.18059001 |
| 73 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.15456126 |
| 74 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.14690940 |
| 75 | EWS_26573619_Chip-Seq_HEK293_Human | 1.13704144 |
| 76 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.08922492 |
| 77 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 1.08765022 |
| 78 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.05002534 |
| 79 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.04888533 |
| 80 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 1.04120892 |
| 81 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.03149291 |
| 82 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.01726410 |
| 83 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.01630199 |
| 84 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 1.01445533 |
| 85 | GATA1_22025678_ChIP-Seq_K562_Human | 1.00423824 |
| 86 | P300_19829295_ChIP-Seq_ESCs_Human | 1.00026568 |
| 87 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.98948847 |
| 88 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 0.96949997 |
| 89 | CIITA_25753668_ChIP-Seq_RAJI_Human | 0.96163392 |
| 90 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.96163309 |
| 91 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.95294319 |
| 92 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 0.93315372 |
| 93 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.92603467 |
| 94 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.91812034 |
| 95 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.89767326 |
| 96 | GBX2_23144817_ChIP-Seq_PC3_Human | 0.87244428 |
| 97 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.86458026 |
| 98 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.86433477 |
| 99 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.84370941 |
| 100 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.83644224 |
| 101 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.82775332 |
| 102 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 0.82363329 |
| 103 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.82038654 |
| 104 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.81316941 |
| 105 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 0.81304477 |
| 106 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.81004308 |
| 107 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 0.79324554 |
| 108 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 0.78038848 |
| 109 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 0.77876880 |
| 110 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.77152491 |
| 111 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 0.77070914 |
| 112 | TP53_22573176_ChIP-Seq_HFKS_Human | 0.75628574 |
| 113 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.75012056 |
| 114 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 0.74900481 |
| 115 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.74525520 |
| 116 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.73985917 |
| 117 | ELF5_23300383_ChIP-Seq_T47D_Human | 0.73843284 |
| 118 | * BRD4_25478319_ChIP-Seq_HGPS_Human | 0.73244664 |
| 119 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.72059354 |
| 120 | * FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.71475130 |
| 121 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 0.69223512 |
| 122 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.68916499 |
| 123 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 0.68847179 |
| 124 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 0.67086596 |
| 125 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 0.66962429 |
| 126 | SALL4_22934838_ChIP-ChIP_CD34+_Human | 0.66944672 |
| 127 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.63087085 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004147_increased_porphyrin_level | 4.00670440 |
| 2 | MP0003880_abnormal_central_pattern | 3.95397116 |
| 3 | MP0001529_abnormal_vocalization | 3.78765205 |
| 4 | MP0010094_abnormal_chromosome_stability | 3.07803675 |
| 5 | MP0003656_abnormal_erythrocyte_physiolo | 2.98686667 |
| 6 | MP0008057_abnormal_DNA_replication | 2.93621942 |
| 7 | MP0008877_abnormal_DNA_methylation | 2.78984333 |
| 8 | MP0008058_abnormal_DNA_repair | 2.73068252 |
| 9 | MP0006035_abnormal_mitochondrial_morpho | 2.64588604 |
| 10 | MP0003693_abnormal_embryo_hatching | 2.60049247 |
| 11 | MP0004957_abnormal_blastocyst_morpholog | 2.58873331 |
| 12 | MP0003890_abnormal_embryonic-extraembry | 2.53411061 |
| 13 | MP0006036_abnormal_mitochondrial_physio | 2.42223334 |
| 14 | MP0002736_abnormal_nociception_after | 2.40080403 |
| 15 | MP0003111_abnormal_nucleus_morphology | 2.26104998 |
| 16 | MP0003950_abnormal_plasma_membrane | 2.19496490 |
| 17 | MP0001905_abnormal_dopamine_level | 2.12519117 |
| 18 | MP0003123_paternal_imprinting | 2.07208864 |
| 19 | MP0001188_hyperpigmentation | 2.03611369 |
| 20 | MP0001968_abnormal_touch/_nociception | 2.02539499 |
| 21 | MP0003077_abnormal_cell_cycle | 1.98751976 |
| 22 | MP0002876_abnormal_thyroid_physiology | 1.97289405 |
| 23 | MP0009697_abnormal_copulation | 1.96014217 |
| 24 | MP0003941_abnormal_skin_development | 1.95870842 |
| 25 | MP0002396_abnormal_hematopoietic_system | 1.94771504 |
| 26 | MP0010352_gastrointestinal_tract_polyps | 1.93090069 |
| 27 | MP0009745_abnormal_behavioral_response | 1.89522756 |
| 28 | MP0003786_premature_aging | 1.87400987 |
| 29 | MP0005408_hypopigmentation | 1.86529811 |
| 30 | MP0003806_abnormal_nucleotide_metabolis | 1.82373145 |
| 31 | MP0005646_abnormal_pituitary_gland | 1.82005534 |
| 32 | MP0003787_abnormal_imprinting | 1.78508083 |
| 33 | MP0009046_muscle_twitch | 1.75445120 |
| 34 | MP0002938_white_spotting | 1.74702378 |
| 35 | MP0002064_seizures | 1.72758928 |
| 36 | MP0004142_abnormal_muscle_tone | 1.71439067 |
| 37 | MP0006072_abnormal_retinal_apoptosis | 1.70821118 |
| 38 | MP0002102_abnormal_ear_morphology | 1.68231718 |
| 39 | MP0005075_abnormal_melanosome_morpholog | 1.67944364 |
| 40 | MP0006054_spinal_hemorrhage | 1.66614372 |
| 41 | MP0003186_abnormal_redox_activity | 1.66515907 |
| 42 | MP0008007_abnormal_cellular_replicative | 1.66182738 |
| 43 | MP0001764_abnormal_homeostasis | 1.65684244 |
| 44 | MP0009379_abnormal_foot_pigmentation | 1.62904266 |
| 45 | MP0006276_abnormal_autonomic_nervous | 1.55291478 |
| 46 | MP0002234_abnormal_pharynx_morphology | 1.54116659 |
| 47 | MP0008872_abnormal_physiological_respon | 1.49155664 |
| 48 | MP0010307_abnormal_tumor_latency | 1.48357558 |
| 49 | MP0003635_abnormal_synaptic_transmissio | 1.47709985 |
| 50 | MP0000427_abnormal_hair_cycle | 1.46446237 |
| 51 | MP0002572_abnormal_emotion/affect_behav | 1.42007749 |
| 52 | MP0001501_abnormal_sleep_pattern | 1.41871726 |
| 53 | MP0001730_embryonic_growth_arrest | 1.35762482 |
| 54 | MP0002132_abnormal_respiratory_system | 1.35548190 |
| 55 | MP0003937_abnormal_limbs/digits/tail_de | 1.35033549 |
| 56 | MP0003121_genomic_imprinting | 1.34826599 |
| 57 | MP0001661_extended_life_span | 1.32064849 |
| 58 | MP0002063_abnormal_learning/memory/cond | 1.32055856 |
| 59 | MP0005266_abnormal_metabolism | 1.27927691 |
| 60 | MP0001697_abnormal_embryo_size | 1.25739623 |
| 61 | MP0008875_abnormal_xenobiotic_pharmacok | 1.25047467 |
| 62 | MP0002272_abnormal_nervous_system | 1.23572066 |
| 63 | MP0008932_abnormal_embryonic_tissue | 1.23232492 |
| 64 | MP0002139_abnormal_hepatobiliary_system | 1.22857731 |
| 65 | MP0006292_abnormal_olfactory_placode | 1.22273104 |
| 66 | MP0002084_abnormal_developmental_patter | 1.20002317 |
| 67 | MP0003122_maternal_imprinting | 1.18924839 |
| 68 | MP0005253_abnormal_eye_physiology | 1.17530054 |
| 69 | MP0001293_anophthalmia | 1.16446501 |
| 70 | MP0000490_abnormal_crypts_of | 1.16292561 |
| 71 | MP0000647_abnormal_sebaceous_gland | 1.15738098 |
| 72 | MP0000358_abnormal_cell_content/ | 1.15414861 |
| 73 | MP0004924_abnormal_behavior | 1.14835975 |
| 74 | MP0005386_behavior/neurological_phenoty | 1.14835975 |
| 75 | MP0003183_abnormal_peptide_metabolism | 1.14397980 |
| 76 | MP0001984_abnormal_olfaction | 1.14153096 |
| 77 | MP0005394_taste/olfaction_phenotype | 1.14045980 |
| 78 | MP0005499_abnormal_olfactory_system | 1.14045980 |
| 79 | MP0002067_abnormal_sensory_capabilities | 1.14040574 |
| 80 | MP0003718_maternal_effect | 1.14009496 |
| 81 | MP0001672_abnormal_embryogenesis/_devel | 1.13820656 |
| 82 | MP0005380_embryogenesis_phenotype | 1.13820656 |
| 83 | MP0002822_catalepsy | 1.12350724 |
| 84 | MP0003567_abnormal_fetal_cardiomyocyte | 1.11138943 |
| 85 | MP0005379_endocrine/exocrine_gland_phen | 1.10088616 |
| 86 | MP0002735_abnormal_chemical_nociception | 1.09277553 |
| 87 | MP0005395_other_phenotype | 1.08142804 |
| 88 | MP0005367_renal/urinary_system_phenotyp | 1.08041027 |
| 89 | MP0000516_abnormal_urinary_system | 1.08041027 |
| 90 | MP0005376_homeostasis/metabolism_phenot | 1.07183442 |
| 91 | MP0003943_abnormal_hepatobiliary_system | 1.06751901 |
| 92 | MP0003011_delayed_dark_adaptation | 1.05346683 |
| 93 | MP0002085_abnormal_embryonic_tissue | 1.04417324 |
| 94 | MP0003879_abnormal_hair_cell | 0.97848650 |
| 95 | MP0001986_abnormal_taste_sensitivity | 0.97706730 |
| 96 | MP0000372_irregular_coat_pigmentation | 0.97602226 |
| 97 | MP0005397_hematopoietic_system_phenotyp | 0.96001076 |
| 98 | MP0001545_abnormal_hematopoietic_system | 0.96001076 |
| 99 | MP0005332_abnormal_amino_acid | 0.95457060 |
| 100 | MP0008789_abnormal_olfactory_epithelium | 0.93038455 |
| 101 | MP0000653_abnormal_sex_gland | 0.92896431 |
| 102 | MP0002734_abnormal_mechanical_nocicepti | 0.92665584 |
| 103 | MP0004808_abnormal_hematopoietic_stem | 0.92376608 |
| 104 | MP0002088_abnormal_embryonic_growth/wei | 0.91729940 |
| 105 | MP0002090_abnormal_vision | 0.91387545 |
| 106 | MP0003136_yellow_coat_color | 0.91066661 |
| 107 | MP0008995_early_reproductive_senescence | 0.90982417 |
| 108 | MP0003252_abnormal_bile_duct | 0.90537987 |
| 109 | MP0001440_abnormal_grooming_behavior | 0.89807521 |
| 110 | MP0005636_abnormal_mineral_homeostasis | 0.89756036 |
| 111 | MP0002163_abnormal_gland_morphology | 0.89395901 |
| 112 | MP0003984_embryonic_growth_retardation | 0.89179299 |
| 113 | MP0001145_abnormal_male_reproductive | 0.88256627 |
| 114 | MP0002080_prenatal_lethality | 0.87349928 |
| 115 | MP0000689_abnormal_spleen_morphology | 0.86660716 |
| 116 | MP0002332_abnormal_exercise_endurance | 0.84769643 |
| 117 | MP0001324_abnormal_eye_pigmentation | 0.84421429 |
| 118 | MP0001119_abnormal_female_reproductive | 0.84023386 |
| 119 | MP0001286_abnormal_eye_development | 0.83446503 |
| 120 | MP0001919_abnormal_reproductive_system | 0.83426710 |
| 121 | MP0001664_abnormal_digestion | 0.82505672 |
| 122 | MP0002019_abnormal_tumor_incidence | 0.82401553 |
| 123 | MP0004859_abnormal_synaptic_plasticity | 0.81477803 |
| 124 | MP0002009_preneoplasia | 0.81158576 |
| 125 | MP0002638_abnormal_pupillary_reflex | 0.80753939 |
| 126 | MP0003195_calcinosis | 0.80668408 |
| 127 | MP0005410_abnormal_fertilization | 0.80638758 |
| 128 | MP0002160_abnormal_reproductive_system | 0.80091138 |
| 129 | MP0002837_dystrophic_cardiac_calcinosis | 0.79242403 |
| 130 | MP0003763_abnormal_thymus_physiology | 0.78971048 |
| 131 | MP0005220_abnormal_exocrine_pancreas | 0.78078730 |
| 132 | MP0002877_abnormal_melanocyte_morpholog | 0.77685696 |
| 133 | MP0000313_abnormal_cell_death | 0.77433350 |
| 134 | MP0005171_absent_coat_pigmentation | 0.77235427 |
| 135 | MP0002722_abnormal_immune_system | 0.76983210 |
| 136 | MP0005084_abnormal_gallbladder_morpholo | 0.76910638 |
| 137 | MP0002398_abnormal_bone_marrow | 0.76620060 |
| 138 | MP0002751_abnormal_autonomic_nervous | 0.76195731 |
| 139 | MP0002111_abnormal_tail_morphology | 0.75388456 |
| 140 | MP0002557_abnormal_social/conspecific_i | 0.75383338 |
| 141 | MP0002086_abnormal_extraembryonic_tissu | 0.75324874 |
| 142 | MP0004215_abnormal_myocardial_fiber | 0.75137760 |
| 143 | MP0004197_abnormal_fetal_growth/weight/ | 0.72174010 |
| 144 | MP0000350_abnormal_cell_proliferation | 0.71712156 |
| 145 | MP0003755_abnormal_palate_morphology | 0.70909783 |
| 146 | MP0002210_abnormal_sex_determination | 0.70433793 |
| 147 | MP0002233_abnormal_nose_morphology | 0.68059335 |
| 148 | MP0003868_abnormal_feces_composition | 0.67865005 |
| 149 | MP0002282_abnormal_trachea_morphology | 0.67563395 |
| 150 | MP0005365_abnormal_bile_salt | 0.67425361 |
| 151 | MP0005391_vision/eye_phenotype | 0.66946810 |
| 152 | MP0005389_reproductive_system_phenotype | 0.66392834 |
| 153 | MP0001929_abnormal_gametogenesis | 0.66176677 |
| 154 | MP0009333_abnormal_splenocyte_physiolog | 0.66159977 |
| 155 | MP0005551_abnormal_eye_electrophysiolog | 0.66128554 |
| 156 | MP0003119_abnormal_digestive_system | 0.66031942 |
| 157 | MP0000428_abnormal_craniofacial_morphol | 0.65722413 |
| 158 | MP0002095_abnormal_skin_pigmentation | 0.62881256 |
| 159 | MP0002429_abnormal_blood_cell | 0.58435177 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 5.34349901 |
| 2 | Acute necrotizing encephalopathy (HP:0006965) | 5.14869603 |
| 3 | Abnormal mitochondria in muscle tissue (HP:0008316) | 5.05534480 |
| 4 | Mitochondrial inheritance (HP:0001427) | 4.74429047 |
| 5 | Increased CSF lactate (HP:0002490) | 4.45687480 |
| 6 | Hepatocellular necrosis (HP:0001404) | 4.43599861 |
| 7 | Progressive macrocephaly (HP:0004481) | 4.25317343 |
| 8 | Acute encephalopathy (HP:0006846) | 4.19889666 |
| 9 | Abnormal number of erythroid precursors (HP:0012131) | 4.10888106 |
| 10 | Abnormality of cells of the erythroid lineage (HP:0012130) | 4.10327561 |
| 11 | Birth length less than 3rd percentile (HP:0003561) | 4.03030362 |
| 12 | Increased serum pyruvate (HP:0003542) | 3.68973263 |
| 13 | Abnormality of glycolysis (HP:0004366) | 3.68973263 |
| 14 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.67104724 |
| 15 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.67104724 |
| 16 | Hepatic necrosis (HP:0002605) | 3.65711334 |
| 17 | Aplastic anemia (HP:0001915) | 3.55021223 |
| 18 | Increased serum lactate (HP:0002151) | 3.44539740 |
| 19 | Lactic acidosis (HP:0003128) | 3.30726549 |
| 20 | 3-Methylglutaconic aciduria (HP:0003535) | 3.29770681 |
| 21 | Focal motor seizures (HP:0011153) | 3.22397497 |
| 22 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 3.17779025 |
| 23 | Colon cancer (HP:0003003) | 3.17000888 |
| 24 | Exercise intolerance (HP:0003546) | 2.98597420 |
| 25 | Cerebral edema (HP:0002181) | 2.97857687 |
| 26 | Abnormality of the ileum (HP:0001549) | 2.96905634 |
| 27 | Increased hepatocellular lipid droplets (HP:0006565) | 2.95680008 |
| 28 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.94970917 |
| 29 | Abnormality of alanine metabolism (HP:0010916) | 2.94970917 |
| 30 | Hyperalaninemia (HP:0003348) | 2.94970917 |
| 31 | Microvesicular hepatic steatosis (HP:0001414) | 2.88756144 |
| 32 | Epileptic encephalopathy (HP:0200134) | 2.87707333 |
| 33 | Increased intramyocellular lipid droplets (HP:0012240) | 2.83961655 |
| 34 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.80432487 |
| 35 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.80432487 |
| 36 | Abnormal protein glycosylation (HP:0012346) | 2.80432487 |
| 37 | Abnormal glycosylation (HP:0012345) | 2.80432487 |
| 38 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.79303588 |
| 39 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.77627434 |
| 40 | Reticulocytopenia (HP:0001896) | 2.74572799 |
| 41 | Abnormal hair whorl (HP:0010721) | 2.73359743 |
| 42 | Oral leukoplakia (HP:0002745) | 2.71833924 |
| 43 | Optic disc pallor (HP:0000543) | 2.70147271 |
| 44 | Pancreatic islet-cell hyperplasia (HP:0004510) | 2.69003300 |
| 45 | Hyperventilation (HP:0002883) | 2.68158086 |
| 46 | Respiratory failure (HP:0002878) | 2.66356405 |
| 47 | Abnormality of methionine metabolism (HP:0010901) | 2.64933359 |
| 48 | Lipid accumulation in hepatocytes (HP:0006561) | 2.60552847 |
| 49 | Poor suck (HP:0002033) | 2.60241476 |
| 50 | Abnormal gallbladder physiology (HP:0012438) | 2.60002782 |
| 51 | Cholecystitis (HP:0001082) | 2.60002782 |
| 52 | Methylmalonic acidemia (HP:0002912) | 2.54531908 |
| 53 | Hypoglycemic coma (HP:0001325) | 2.54298157 |
| 54 | Reduced antithrombin III activity (HP:0001976) | 2.53322881 |
| 55 | Macrocytic anemia (HP:0001972) | 2.49959913 |
| 56 | Hyperinsulinemic hypoglycemia (HP:0000825) | 2.49657684 |
| 57 | Agnosia (HP:0010524) | 2.47366804 |
| 58 | IgM deficiency (HP:0002850) | 2.45154767 |
| 59 | Leukodystrophy (HP:0002415) | 2.44990548 |
| 60 | Small hand (HP:0200055) | 2.41760796 |
| 61 | Abnormality of DNA repair (HP:0003254) | 2.41530142 |
| 62 | Pallor (HP:0000980) | 2.41189174 |
| 63 | Breast hypoplasia (HP:0003187) | 2.39051024 |
| 64 | Abnormal spermatogenesis (HP:0008669) | 2.37502057 |
| 65 | Type I transferrin isoform profile (HP:0003642) | 2.37174886 |
| 66 | Delusions (HP:0000746) | 2.37167938 |
| 67 | Protruding tongue (HP:0010808) | 2.36089088 |
| 68 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 2.34682667 |
| 69 | Respiratory difficulties (HP:0002880) | 2.32697585 |
| 70 | Hypobetalipoproteinemia (HP:0003563) | 2.31234428 |
| 71 | Increased muscle lipid content (HP:0009058) | 2.30117306 |
| 72 | Hypoglycemic seizures (HP:0002173) | 2.27793854 |
| 73 | Neoplasm of the adrenal gland (HP:0100631) | 2.27681833 |
| 74 | Abnormality of the pancreatic islet cells (HP:0006476) | 2.27170670 |
| 75 | Abnormality of endocrine pancreas physiology (HP:0012093) | 2.27170670 |
| 76 | Gonadotropin excess (HP:0000837) | 2.25259402 |
| 77 | Renal Fanconi syndrome (HP:0001994) | 2.24582232 |
| 78 | Pancreatic cysts (HP:0001737) | 2.23826912 |
| 79 | Hypoplastic pelvis (HP:0008839) | 2.23031661 |
| 80 | Nephrogenic diabetes insipidus (HP:0009806) | 2.20660883 |
| 81 | Exertional dyspnea (HP:0002875) | 2.20264883 |
| 82 | True hermaphroditism (HP:0010459) | 2.19319589 |
| 83 | Abnormality of chromosome stability (HP:0003220) | 2.17794161 |
| 84 | Atonic seizures (HP:0010819) | 2.16671880 |
| 85 | Prominent metopic ridge (HP:0005487) | 2.16631579 |
| 86 | Emotional lability (HP:0000712) | 2.16307804 |
| 87 | Congenital primary aphakia (HP:0007707) | 2.16043991 |
| 88 | Abnormality of urine glucose concentration (HP:0011016) | 2.16010942 |
| 89 | Glycosuria (HP:0003076) | 2.16010942 |
| 90 | Glioma (HP:0009733) | 2.15929081 |
| 91 | CNS demyelination (HP:0007305) | 2.15390518 |
| 92 | Pancytopenia (HP:0001876) | 2.13954513 |
| 93 | Chromsome breakage (HP:0040012) | 2.13119197 |
| 94 | Medial flaring of the eyebrow (HP:0010747) | 2.12634241 |
| 95 | Abnormality of the preputium (HP:0100587) | 2.12204627 |
| 96 | Abnormal lung lobation (HP:0002101) | 2.10063000 |
| 97 | Symptomatic seizures (HP:0011145) | 2.09549915 |
| 98 | Small intestinal stenosis (HP:0012848) | 2.09420116 |
| 99 | Duodenal stenosis (HP:0100867) | 2.09420116 |
| 100 | Pancreatic fibrosis (HP:0100732) | 2.06120859 |
| 101 | Abnormality of the anterior horn cell (HP:0006802) | 2.05923920 |
| 102 | Degeneration of anterior horn cells (HP:0002398) | 2.05923920 |
| 103 | Gait imbalance (HP:0002141) | 2.05715835 |
| 104 | Volvulus (HP:0002580) | 2.05301381 |
| 105 | Ragged-red muscle fibers (HP:0003200) | 2.05092741 |
| 106 | Abnormality of the pons (HP:0007361) | 2.04855924 |
| 107 | Sloping forehead (HP:0000340) | 2.04837118 |
| 108 | Renal cortical cysts (HP:0000803) | 2.04530941 |
| 109 | Entropion (HP:0000621) | 2.01837905 |
| 110 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.01155800 |
| 111 | Hypoplasia of the pons (HP:0012110) | 2.00820080 |
| 112 | Postnatal microcephaly (HP:0005484) | 2.00691969 |
| 113 | Ependymoma (HP:0002888) | 2.00510479 |
| 114 | Absent thumb (HP:0009777) | 1.99196462 |
| 115 | Thrombocytosis (HP:0001894) | 1.98024164 |
| 116 | Hyperglycinemia (HP:0002154) | 1.97908633 |
| 117 | Cerebral hypomyelination (HP:0006808) | 1.97408002 |
| 118 | Poikilocytosis (HP:0004447) | 1.97331743 |
| 119 | Ketoacidosis (HP:0001993) | 1.97282018 |
| 120 | Absent epiphyses (HP:0010577) | 1.96780139 |
| 121 | Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003) | 1.96780139 |
| 122 | Abnormality of serum amino acid levels (HP:0003112) | 1.96081390 |
| 123 | Adrenal hypoplasia (HP:0000835) | 1.95962551 |
| 124 | Abnormality of the labia minora (HP:0012880) | 1.95668058 |
| 125 | Astrocytoma (HP:0009592) | 1.94122615 |
| 126 | Abnormality of the astrocytes (HP:0100707) | 1.94122615 |
| 127 | Irregular epiphyses (HP:0010582) | 1.93414219 |
| 128 | Methylmalonic aciduria (HP:0012120) | 1.93159978 |
| 129 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 1.92775330 |
| 130 | Secondary amenorrhea (HP:0000869) | 1.91204469 |
| 131 | Long foot (HP:0001833) | 1.90326303 |
| 132 | Myelodysplasia (HP:0002863) | 1.90256367 |
| 133 | Abnormality of reticulocytes (HP:0004312) | 1.89928409 |
| 134 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 1.89001483 |
| 135 | Gliosis (HP:0002171) | 1.88799915 |
| 136 | Abnormality of the metopic suture (HP:0005556) | 1.88121771 |
| 137 | Febrile seizures (HP:0002373) | 1.87768324 |
| 138 | Abnormality of the duodenum (HP:0002246) | 1.86748054 |
| 139 | Progressive inability to walk (HP:0002505) | 1.86495876 |
| 140 | CNS hypomyelination (HP:0003429) | 1.85611410 |
| 141 | Type 2 muscle fiber atrophy (HP:0003554) | 1.84467806 |
| 142 | Neoplasm of the adrenal cortex (HP:0100641) | 1.84453834 |
| 143 | Type II lissencephaly (HP:0007260) | 1.84385037 |
| 144 | Cholelithiasis (HP:0001081) | 1.81883135 |
| 145 | Female pseudohermaphroditism (HP:0010458) | 1.81706655 |
| 146 | Abnormal number of incisors (HP:0011064) | 1.81587772 |
| 147 | Brushfield spots (HP:0001088) | 1.80275420 |
| 148 | Unsteady gait (HP:0002317) | 1.79921926 |
| 149 | Abnormality of the carotid arteries (HP:0005344) | 1.77805007 |
| 150 | Poor head control (HP:0002421) | 1.77526111 |
| 151 | Thyroid-stimulating hormone excess (HP:0002925) | 1.75237030 |
| 152 | Hypothermia (HP:0002045) | 1.75166369 |
| 153 | Sensory axonal neuropathy (HP:0003390) | 1.75133670 |
| 154 | Abnormality of the renal cortex (HP:0011035) | 1.73636393 |
| 155 | Sclerocornea (HP:0000647) | 1.73491796 |
| 156 | Clubbing of toes (HP:0100760) | 1.73431867 |
| 157 | Megaloblastic anemia (HP:0001889) | 1.70787335 |
| 158 | Cellular immunodeficiency (HP:0005374) | 1.69995216 |
| 159 | Poor coordination (HP:0002370) | 1.68429888 |
| 160 | Meckel diverticulum (HP:0002245) | 1.66523700 |
| 161 | Bone marrow hypocellularity (HP:0005528) | 1.66381400 |
| 162 | Premature graying of hair (HP:0002216) | 1.65742131 |
| 163 | 11 pairs of ribs (HP:0000878) | 1.65680693 |
| 164 | Rough bone trabeculation (HP:0100670) | 1.65251608 |
| 165 | Hyperbilirubinemia (HP:0002904) | 1.65019807 |
| 166 | Cutaneous photosensitivity (HP:0000992) | 1.64888678 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | CASK | 4.53749405 |
| 2 | CCNB1 | 3.52960999 |
| 3 | MAP3K12 | 3.51032137 |
| 4 | STK16 | 3.38331555 |
| 5 | CDK19 | 3.28893925 |
| 6 | BUB1 | 3.09741012 |
| 7 | EIF2AK1 | 2.81749711 |
| 8 | CDC7 | 2.62681930 |
| 9 | TSSK6 | 2.59593159 |
| 10 | DAPK1 | 2.58739859 |
| 11 | TRIM28 | 2.58459763 |
| 12 | PBK | 2.52009142 |
| 13 | ZAK | 2.42761240 |
| 14 | WEE1 | 2.36300131 |
| 15 | FRK | 2.29206673 |
| 16 | MAP2K7 | 2.24548282 |
| 17 | NUAK1 | 1.94863348 |
| 18 | NME1 | 1.87004888 |
| 19 | NME2 | 1.85258582 |
| 20 | PLK2 | 1.84317531 |
| 21 | VRK1 | 1.82393908 |
| 22 | MAP3K4 | 1.72768473 |
| 23 | ACVR1B | 1.68051419 |
| 24 | PDK2 | 1.67220848 |
| 25 | CDK8 | 1.66413421 |
| 26 | WNK3 | 1.59077402 |
| 27 | MKNK2 | 1.56571978 |
| 28 | MST4 | 1.56211810 |
| 29 | NEK1 | 1.51347027 |
| 30 | TLK1 | 1.51316766 |
| 31 | SRPK1 | 1.50658435 |
| 32 | MKNK1 | 1.45904430 |
| 33 | VRK2 | 1.35350218 |
| 34 | STK3 | 1.31311491 |
| 35 | ERBB3 | 1.30863500 |
| 36 | SIK3 | 1.30531907 |
| 37 | GRK1 | 1.26553479 |
| 38 | BRSK2 | 1.22428200 |
| 39 | PASK | 1.20478047 |
| 40 | EIF2AK3 | 1.20451029 |
| 41 | ADRBK2 | 1.20199695 |
| 42 | CLK1 | 1.14021747 |
| 43 | TAF1 | 1.13826716 |
| 44 | AKT3 | 1.13633960 |
| 45 | LATS1 | 1.11809337 |
| 46 | CHEK2 | 1.11612775 |
| 47 | BCR | 1.09973585 |
| 48 | CSNK1G1 | 1.08203919 |
| 49 | GRK6 | 1.08166593 |
| 50 | ERBB4 | 1.07989012 |
| 51 | STK38L | 1.05528297 |
| 52 | CSNK1G3 | 1.03957576 |
| 53 | STK24 | 1.03131171 |
| 54 | TNK2 | 1.00485535 |
| 55 | PLK3 | 0.99978561 |
| 56 | BRSK1 | 0.98944522 |
| 57 | PLK4 | 0.97045726 |
| 58 | ATR | 0.95890370 |
| 59 | NEK9 | 0.93062669 |
| 60 | MAP4K2 | 0.92433927 |
| 61 | MAPKAPK3 | 0.90361693 |
| 62 | ATM | 0.90005320 |
| 63 | DAPK2 | 0.89951389 |
| 64 | BRAF | 0.89680068 |
| 65 | BMPR1B | 0.88333189 |
| 66 | PLK1 | 0.88091735 |
| 67 | MAP2K4 | 0.87691210 |
| 68 | NEK2 | 0.86344909 |
| 69 | OXSR1 | 0.84726621 |
| 70 | GRK5 | 0.84098106 |
| 71 | CSNK1A1L | 0.83885835 |
| 72 | TIE1 | 0.83539064 |
| 73 | MYLK | 0.83113507 |
| 74 | MELK | 0.80887729 |
| 75 | CSNK1G2 | 0.80872954 |
| 76 | NTRK3 | 0.80081657 |
| 77 | TTK | 0.79177302 |
| 78 | GRK7 | 0.78464649 |
| 79 | TGFBR1 | 0.77160067 |
| 80 | AURKB | 0.74711151 |
| 81 | TNIK | 0.73860392 |
| 82 | RPS6KB2 | 0.72835666 |
| 83 | BMPR2 | 0.70983488 |
| 84 | BCKDK | 0.69423386 |
| 85 | STK10 | 0.68609783 |
| 86 | AURKA | 0.68365103 |
| 87 | BRD4 | 0.67876904 |
| 88 | WNK4 | 0.66339027 |
| 89 | TEC | 0.65384132 |
| 90 | PRPF4B | 0.65201806 |
| 91 | CDK18 | 0.63560678 |
| 92 | PNCK | 0.62627700 |
| 93 | LIMK1 | 0.59196713 |
| 94 | PRKCG | 0.59168204 |
| 95 | ADRBK1 | 0.59011559 |
| 96 | STK4 | 0.58677327 |
| 97 | CDK15 | 0.56952896 |
| 98 | CSNK2A2 | 0.56757871 |
| 99 | MINK1 | 0.56743959 |
| 100 | DYRK1A | 0.56461417 |
| 101 | CSNK2A1 | 0.56099299 |
| 102 | YES1 | 0.56088313 |
| 103 | ALK | 0.55787611 |
| 104 | MAPKAPK5 | 0.55046543 |
| 105 | SYK | 0.53120040 |
| 106 | STK39 | 0.53086562 |
| 107 | CDK11A | 0.52861460 |
| 108 | PDK3 | 0.50363416 |
| 109 | PDK4 | 0.50363416 |
| 110 | KIT | 0.50331170 |
| 111 | CDK7 | 0.49600505 |
| 112 | PTK2B | 0.49351036 |
| 113 | EIF2AK2 | 0.49129700 |
| 114 | MAP3K6 | 0.48439727 |
| 115 | IRAK4 | 0.47792498 |
| 116 | CDK3 | 0.47079859 |
| 117 | EPHA4 | 0.46885454 |
| 118 | CDK14 | 0.46706433 |
| 119 | FES | 0.46619844 |
| 120 | TGFBR2 | 0.44705423 |
| 121 | DYRK3 | 0.44666262 |
| 122 | SCYL2 | 0.44273242 |
| 123 | FGFR1 | 0.42436960 |
| 124 | TXK | 0.41523558 |
| 125 | FLT3 | 0.40702837 |
| 126 | CDK4 | 0.40410207 |
| 127 | PIM1 | 0.40244600 |
| 128 | CSNK1E | 0.40022766 |
| 129 | PRKCE | 0.40008320 |
| 130 | PRKDC | 0.39036210 |
| 131 | PIM2 | 0.36649501 |
| 132 | NLK | 0.36590281 |
| 133 | MET | 0.34555948 |
| 134 | SGK2 | 0.34521670 |
| 135 | DAPK3 | 0.34508171 |
| 136 | CDK1 | 0.34349306 |
| 137 | MAP3K11 | 0.33727799 |
| 138 | CSF1R | 0.33499947 |
| 139 | PRKCI | 0.33145749 |
| 140 | RIPK4 | 0.33013002 |
| 141 | PAK4 | 0.32775215 |
| 142 | LYN | 0.31540041 |
| 143 | RPS6KB1 | 0.30468813 |
| 144 | MAPK4 | 0.27961543 |
| 145 | CHEK1 | 0.27920533 |
| 146 | CSNK1D | 0.27480445 |
| 147 | CAMKK2 | 0.27352408 |
| 148 | CSNK1A1 | 0.26244983 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA replication_Homo sapiens_hsa03030 | 4.13437036 |
| 2 | Proteasome_Homo sapiens_hsa03050 | 3.83733369 |
| 3 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.76523494 |
| 4 | Ribosome_Homo sapiens_hsa03010 | 3.76283321 |
| 5 | Mismatch repair_Homo sapiens_hsa03430 | 3.29469440 |
| 6 | Parkinsons disease_Homo sapiens_hsa05012 | 3.10676655 |
| 7 | RNA polymerase_Homo sapiens_hsa03020 | 2.77743627 |
| 8 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.45770802 |
| 9 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 2.45001163 |
| 10 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.36659126 |
| 11 | Huntingtons disease_Homo sapiens_hsa05016 | 2.34151373 |
| 12 | Homologous recombination_Homo sapiens_hsa03440 | 2.23137632 |
| 13 | Spliceosome_Homo sapiens_hsa03040 | 2.18455054 |
| 14 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 2.14424057 |
| 15 | Steroid biosynthesis_Homo sapiens_hsa00100 | 2.14147927 |
| 16 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 2.11930702 |
| 17 | Alzheimers disease_Homo sapiens_hsa05010 | 2.11222400 |
| 18 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.10090807 |
| 19 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.03674025 |
| 20 | Base excision repair_Homo sapiens_hsa03410 | 1.91800626 |
| 21 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.91239271 |
| 22 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.86381765 |
| 23 | Nicotine addiction_Homo sapiens_hsa05033 | 1.80886903 |
| 24 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.76754470 |
| 25 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.75092489 |
| 26 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.75076166 |
| 27 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 1.71456159 |
| 28 | RNA transport_Homo sapiens_hsa03013 | 1.60518599 |
| 29 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.58179942 |
| 30 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.53756502 |
| 31 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.49576800 |
| 32 | Protein export_Homo sapiens_hsa03060 | 1.44505926 |
| 33 | Purine metabolism_Homo sapiens_hsa00230 | 1.42134806 |
| 34 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.37468892 |
| 35 | RNA degradation_Homo sapiens_hsa03018 | 1.36685206 |
| 36 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.36559946 |
| 37 | Cell cycle_Homo sapiens_hsa04110 | 1.33393890 |
| 38 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.31885884 |
| 39 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.27445815 |
| 40 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 1.25049012 |
| 41 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.24444264 |
| 42 | Basal transcription factors_Homo sapiens_hsa03022 | 1.21017672 |
| 43 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.20684398 |
| 44 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.17866647 |
| 45 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.99354438 |
| 46 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.97630501 |
| 47 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.94897573 |
| 48 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.92253207 |
| 49 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.89436166 |
| 50 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.89232242 |
| 51 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.87523906 |
| 52 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.86529133 |
| 53 | Carbon metabolism_Homo sapiens_hsa01200 | 0.84621959 |
| 54 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.84059087 |
| 55 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.81286236 |
| 56 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.80515517 |
| 57 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.77902378 |
| 58 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.77706409 |
| 59 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.77094797 |
| 60 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.75550649 |
| 61 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.73531153 |
| 62 | * Metabolic pathways_Homo sapiens_hsa01100 | 0.73459355 |
| 63 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 0.71010172 |
| 64 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.67410198 |
| 65 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.67222954 |
| 66 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.66557248 |
| 67 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.64307978 |
| 68 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.62991098 |
| 69 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.62458605 |
| 70 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.62277094 |
| 71 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.62018576 |
| 72 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.60812432 |
| 73 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.60504955 |
| 74 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.59300266 |
| 75 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.57634719 |
| 76 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.56607530 |
| 77 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.55225017 |
| 78 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.54912572 |
| 79 | Alcoholism_Homo sapiens_hsa05034 | 0.52392484 |
| 80 | Phagosome_Homo sapiens_hsa04145 | 0.50382601 |
| 81 | Lysine degradation_Homo sapiens_hsa00310 | 0.50068727 |
| 82 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.49988536 |
| 83 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.49866999 |
| 84 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.49420321 |
| 85 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.48661949 |
| 86 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.47484688 |
| 87 | Sulfur relay system_Homo sapiens_hsa04122 | 0.46180017 |
| 88 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.45429491 |
| 89 | Galactose metabolism_Homo sapiens_hsa00052 | 0.45422710 |
| 90 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.44952821 |
| 91 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.44664741 |
| 92 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.43777569 |
| 93 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.43771046 |
| 94 | Morphine addiction_Homo sapiens_hsa05032 | 0.43348585 |
| 95 | Amphetamine addiction_Homo sapiens_hsa05031 | 0.43174970 |
| 96 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.42042719 |
| 97 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.41467938 |
| 98 | Peroxisome_Homo sapiens_hsa04146 | 0.39778669 |
| 99 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.39071287 |
| 100 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.38044753 |
| 101 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.37900082 |
| 102 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.37859329 |
| 103 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.36989595 |
| 104 | * Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.36470731 |
| 105 | Olfactory transduction_Homo sapiens_hsa04740 | 0.36185303 |
| 106 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.34618637 |
| 107 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.34536766 |
| 108 | Taste transduction_Homo sapiens_hsa04742 | 0.34354367 |
| 109 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.33505777 |
| 110 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.31693792 |
| 111 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.29704222 |
| 112 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.29687484 |
| 113 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.29645643 |
| 114 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.29558543 |
| 115 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.28518200 |
| 116 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.28278378 |
| 117 | GABAergic synapse_Homo sapiens_hsa04727 | 0.28200182 |
| 118 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.26025397 |
| 119 | Retinol metabolism_Homo sapiens_hsa00830 | 0.24408418 |
| 120 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.23855276 |
| 121 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.23177070 |
| 122 | Long-term potentiation_Homo sapiens_hsa04720 | 0.21740183 |
| 123 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.20178369 |
| 124 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.20017853 |
| 125 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.19796758 |
| 126 | Phototransduction_Homo sapiens_hsa04744 | 0.19028182 |
| 127 | Circadian entrainment_Homo sapiens_hsa04713 | 0.18417107 |
| 128 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.17694963 |
| 129 | Legionellosis_Homo sapiens_hsa05134 | 0.17519665 |
| 130 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.16911097 |
| 131 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.15346180 |
| 132 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.14445863 |
| 133 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.12721497 |
| 134 | Dopaminergic synapse_Homo sapiens_hsa04728 | 0.10646269 |

