NANS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme that functions in the biosynthetic pathways of sialic acids. In vitro, the encoded protein uses N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), respectively; however, it exhibits much higher activity toward the Neu5Ac phosphate product. In insect cells, expression of this gene results in Neu5Ac and KDN production. This gene is related to the E. coli sialic acid synthase gene neuB, and it can partially restore sialic acid synthase activity in an E. coli neuB-negative mutant. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.60732693
2viral transcription (GO:0019083)5.20007209
3translational termination (GO:0006415)5.03202699
4SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.80578680
5protein targeting to ER (GO:0045047)4.68201888
6cotranslational protein targeting to membrane (GO:0006613)4.64155245
7translational elongation (GO:0006414)4.50067942
8ribosomal small subunit biogenesis (GO:0042274)4.45249889
9establishment of protein localization to endoplasmic reticulum (GO:0072599)4.44685092
10protein localization to endoplasmic reticulum (GO:0070972)4.34816743
11translational initiation (GO:0006413)4.15008486
12GDP-mannose metabolic process (GO:0019673)4.14625463
13nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.11571322
14maturation of SSU-rRNA (GO:0030490)4.10589335
15viral life cycle (GO:0019058)4.01876759
16DNA strand elongation involved in DNA replication (GO:0006271)3.98129084
17formation of translation preinitiation complex (GO:0001731)3.98065166
18cellular protein complex disassembly (GO:0043624)3.92441944
19telomere maintenance via semi-conservative replication (GO:0032201)3.80825510
20DNA strand elongation (GO:0022616)3.77218177
21folic acid-containing compound biosynthetic process (GO:0009396)3.68326806
22ribosomal large subunit biogenesis (GO:0042273)3.67327030
23DNA unwinding involved in DNA replication (GO:0006268)3.61684125
24protein complex disassembly (GO:0043241)3.52202107
25protein localization to kinetochore (GO:0034501)3.48964558
26COPI coating of Golgi vesicle (GO:0048205)3.38477912
27Golgi transport vesicle coating (GO:0048200)3.38477912
28telomere maintenance via recombination (GO:0000722)3.37390621
29proteasome assembly (GO:0043248)3.34330761
30DNA replication initiation (GO:0006270)3.33103462
31macromolecular complex disassembly (GO:0032984)3.31165142
32translation (GO:0006412)3.18237123
33mitotic recombination (GO:0006312)3.13445413
34protein maturation by protein folding (GO:0022417)3.13357784
35protein targeting to membrane (GO:0006612)3.09971458
36ribonucleoprotein complex biogenesis (GO:0022613)3.08214550
37nuclear-transcribed mRNA catabolic process (GO:0000956)3.07293716
38ncRNA 3-end processing (GO:0043628)3.01568869
39mitotic nuclear envelope disassembly (GO:0007077)3.01408686
40regulation of chemokine biosynthetic process (GO:0045073)2.98228200
41deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.97273271
42DNA deamination (GO:0045006)2.97059552
43T cell apoptotic process (GO:0070231)2.95960868
44telomere maintenance via telomere lengthening (GO:0010833)2.95264713
45regulation of vitamin D biosynthetic process (GO:0060556)2.94038920
46mRNA catabolic process (GO:0006402)2.93021580
47positive regulation of chemokine biosynthetic process (GO:0045080)2.91961480
48regulation of protein heterodimerization activity (GO:0043497)2.90732313
49positive regulation of prostaglandin secretion (GO:0032308)2.90526578
50purine deoxyribonucleotide catabolic process (GO:0009155)2.89970292
51regulation of vitamin metabolic process (GO:0030656)2.89880293
52RNA catabolic process (GO:0006401)2.89352381
53protein localization to chromosome, centromeric region (GO:0071459)2.89155875
54negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.88422339
55DNA replication checkpoint (GO:0000076)2.87680576
56negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.85784301
57nucleotide-excision repair, DNA gap filling (GO:0006297)2.85695414
58DNA replication-dependent nucleosome organization (GO:0034723)2.85108810
59DNA replication-dependent nucleosome assembly (GO:0006335)2.85108810
60IMP biosynthetic process (GO:0006188)2.84990662
61glycosphingolipid catabolic process (GO:0046479)2.82339659
62negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.80350705
63Arp2/3 complex-mediated actin nucleation (GO:0034314)2.80333077
64negative regulation of ligase activity (GO:0051352)2.79172912
65negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.79172912
66maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.78651835
67nuclear envelope disassembly (GO:0051081)2.76164672
68membrane disassembly (GO:0030397)2.76164672
69chaperone mediated protein folding requiring cofactor (GO:0051085)2.75739759
70regulation of mitochondrial translation (GO:0070129)2.74993752
71antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.72184840
72antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.72184840
73regulation of chronic inflammatory response (GO:0002676)2.70039868
74nucleobase biosynthetic process (GO:0046112)2.69919965
75regulation of cellular amino acid metabolic process (GO:0006521)2.68552126
76negative regulation of nitric oxide biosynthetic process (GO:0045019)2.67498950
77maternal placenta development (GO:0001893)2.65012155
78positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.64114548
79rRNA processing (GO:0006364)2.61301648
80glycolipid catabolic process (GO:0019377)2.60730566
81regulation of prostaglandin secretion (GO:0032306)2.60534511
82nucleotide-sugar biosynthetic process (GO:0009226)2.59319588
83pseudouridine synthesis (GO:0001522)2.58985112
84pteridine-containing compound biosynthetic process (GO:0042559)2.58303775
85DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.57268709
86negative regulation of RNA splicing (GO:0033119)2.57163713
87rRNA metabolic process (GO:0016072)2.55158221
88regulation of translational termination (GO:0006449)2.54880462
89protein retention in ER lumen (GO:0006621)2.52528890
90NIK/NF-kappaB signaling (GO:0038061)2.52372248
91antigen processing and presentation of endogenous antigen (GO:0019883)2.52240612
92intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.52117636
93signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.52117636
94negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.51841472
95oligosaccharide catabolic process (GO:0009313)2.51517844
96lymphocyte apoptotic process (GO:0070227)2.51183691
97regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.50882478
98response to interferon-beta (GO:0035456)2.50817566
99heterochromatin organization (GO:0070828)2.49783413
100signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.49745685
101signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.49745685
102signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.49745685
103signal transduction involved in DNA damage checkpoint (GO:0072422)2.49106946
104signal transduction involved in DNA integrity checkpoint (GO:0072401)2.49106946
105regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.49061008
106pentose metabolic process (GO:0019321)2.47255520
107mitotic sister chromatid segregation (GO:0000070)2.47097811
108activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.46921489
109nucleobase-containing small molecule interconversion (GO:0015949)2.46305837
110proline biosynthetic process (GO:0006561)2.45354942
111anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.44936622
112IMP metabolic process (GO:0046040)2.44529608
113regulation of podosome assembly (GO:0071801)2.44108136
114immunoglobulin mediated immune response (GO:0016064)2.42946904
115mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.42860963
116ribosome biogenesis (GO:0042254)2.42298169
117pinocytosis (GO:0006907)2.41295825
118mitotic metaphase plate congression (GO:0007080)2.40920041
119negative regulation of myeloid cell apoptotic process (GO:0033033)2.40901097
120ribosome assembly (GO:0042255)2.40678471
121mature B cell differentiation involved in immune response (GO:0002313)2.40589643
122ceramide catabolic process (GO:0046514)2.40243163
123signal transduction involved in cell cycle checkpoint (GO:0072395)2.39461645
124negative regulation of interleukin-12 production (GO:0032695)2.38587308
125chromatin remodeling at centromere (GO:0031055)2.36398981
126regulation of superoxide anion generation (GO:0032928)2.35910954
127UDP-N-acetylglucosamine metabolic process (GO:0006047)2.35229117
128lipopolysaccharide-mediated signaling pathway (GO:0031663)2.34914961
129DNA duplex unwinding (GO:0032508)2.34800866
130pentose-phosphate shunt (GO:0006098)2.34610392
131nucleotide salvage (GO:0043173)2.34265506
132hepatocyte apoptotic process (GO:0097284)2.34172238
133antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.33803794
134antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.32958601
135DNA geometric change (GO:0032392)2.32843989
136antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.32770806
137CENP-A containing nucleosome assembly (GO:0034080)2.32365902
138sister chromatid segregation (GO:0000819)2.32330208
139nuclear pore organization (GO:0006999)2.32089976
140negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.32026269
141maturation of 5.8S rRNA (GO:0000460)2.31806934
142cellular response to interferon-beta (GO:0035458)2.31064570
143pyrimidine-containing compound salvage (GO:0008655)2.29898486
144pyrimidine nucleoside salvage (GO:0043097)2.29898486
145positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.29796978
146negative regulation of B cell apoptotic process (GO:0002903)2.29737247
147purine nucleobase biosynthetic process (GO:0009113)2.29361623
148telomere maintenance (GO:0000723)2.29351838
149purine nucleotide salvage (GO:0032261)2.27473258
150telomere organization (GO:0032200)2.27360167
151leukocyte apoptotic process (GO:0071887)2.26698657
152regulation of interferon-alpha production (GO:0032647)2.26626123
153translesion synthesis (GO:0019985)2.26533118
154kinetochore organization (GO:0051383)2.26046089
155mitotic chromosome condensation (GO:0007076)2.25974916
156DNA replication-independent nucleosome organization (GO:0034724)2.25276937
157DNA replication-independent nucleosome assembly (GO:0006336)2.25276937
158positive regulation of ligase activity (GO:0051351)2.25227711
159protein autoprocessing (GO:0016540)2.24987397
160response to peptidoglycan (GO:0032494)2.24757106
161protein targeting to mitochondrion (GO:0006626)2.24478825
162rRNA modification (GO:0000154)2.23722477
163nuclear envelope reassembly (GO:0031468)2.23621326
164mitotic nuclear envelope reassembly (GO:0007084)2.23621326
1653-UTR-mediated mRNA stabilization (GO:0070935)2.23329086
166oxidative phosphorylation (GO:0006119)2.22855468
167spliceosomal snRNP assembly (GO:0000387)2.22658877
168regulation of mitochondrial membrane potential (GO:0051881)2.21842020
169nuclear pore complex assembly (GO:0051292)2.20705374
170positive regulation of Cdc42 GTPase activity (GO:0043089)2.20691320
171base-excision repair (GO:0006284)2.20065221
172cellular response to arsenic-containing substance (GO:0071243)2.19555814
173membrane lipid catabolic process (GO:0046466)2.19286842
174tetrahydrofolate metabolic process (GO:0046653)2.19274821
175sphingolipid catabolic process (GO:0030149)2.19128069
176deoxyribonucleotide catabolic process (GO:0009264)2.18996946
177histone-serine phosphorylation (GO:0035404)2.18472229
178ATP synthesis coupled proton transport (GO:0015986)2.18133539
179energy coupled proton transport, down electrochemical gradient (GO:0015985)2.18133539
180chaperone-mediated protein transport (GO:0072321)2.17573644
181regulation of RIG-I signaling pathway (GO:0039535)2.17504598
182chromatin assembly or disassembly (GO:0006333)2.14978959

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.05525884
2* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.70287128
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.50335690
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.26976999
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.60313977
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.59080499
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.51949859
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.43196188
9MYC_22102868_ChIP-Seq_BL_Human2.25915490
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.24195411
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.20526626
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.20169994
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.11549550
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.06082983
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.05030686
16TP63_17297297_ChIP-ChIP_HaCaT_Human2.04912550
17XRN2_22483619_ChIP-Seq_HELA_Human2.01927485
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.01584581
19PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.96307135
20SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.95499288
21NELFA_20434984_ChIP-Seq_ESCs_Mouse1.94631477
22JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.92553878
23CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.87552059
24TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.82937072
25VDR_21846776_ChIP-Seq_THP-1_Human1.82747854
26SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.82007042
27ELF1_17652178_ChIP-ChIP_JURKAT_Human1.81368634
28CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.79390450
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.77800703
30VDR_23849224_ChIP-Seq_CD4+_Human1.77051091
31DCP1A_22483619_ChIP-Seq_HELA_Human1.70128589
32E2F1_21310950_ChIP-Seq_MCF-7_Human1.64338103
33* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.64008822
34SRF_21415370_ChIP-Seq_HL-1_Mouse1.63622468
35TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.59826413
36TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.58987076
37AR_21909140_ChIP-Seq_LNCAP_Human1.58737251
38FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.58491500
39FOXP3_21729870_ChIP-Seq_TREG_Human1.57554643
40HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.55269101
41ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.54074045
42SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.52685908
43CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.51970904
44GABP_19822575_ChIP-Seq_HepG2_Human1.51736953
45IRF8_22096565_ChIP-ChIP_GC-B_Human1.48442843
46TTF2_22483619_ChIP-Seq_HELA_Human1.47269913
47BP1_19119308_ChIP-ChIP_Hs578T_Human1.46516908
48* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.46262962
49CIITA_25753668_ChIP-Seq_RAJI_Human1.42384959
50FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.41758780
51* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.41017289
52TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40754500
53CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.39245459
54NANOG_18555785_ChIP-Seq_MESCs_Mouse1.38119866
55PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.37549482
56ELK1_19687146_ChIP-ChIP_HELA_Human1.35931018
57ZFX_18555785_ChIP-Seq_MESCs_Mouse1.35878843
58NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.35728951
59MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.34541360
60STAT3_1855785_ChIP-Seq_MESCs_Mouse1.32779804
61HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31585586
62MYCN_18555785_ChIP-Seq_MESCs_Mouse1.31209508
63RARG_19884340_ChIP-ChIP_MEFs_Mouse1.30926846
64* SPI1_23547873_ChIP-Seq_NB4_Human1.30628383
65* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.28493304
66POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.28181088
67TFEB_21752829_ChIP-Seq_HELA_Human1.27587361
68KDM5A_27292631_Chip-Seq_BREAST_Human1.25820492
69MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.25177754
70MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.24676639
71KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.24506030
72ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.22674712
73CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.20423663
74IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.20246223
75LXR_22292898_ChIP-Seq_THP-1_Human1.18542015
76MAF_26560356_Chip-Seq_TH1_Human1.18365580
77NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.18230506
78ELF1_20517297_ChIP-Seq_JURKAT_Human1.17933373
79UTX_26944678_Chip-Seq_JUKART_Human1.17613880
80MYB_21317192_ChIP-Seq_ERMYB_Mouse1.17365078
81KLF4_18555785_ChIP-Seq_MESCs_Mouse1.16949318
82TET1_21451524_ChIP-Seq_MESCs_Mouse1.15435126
83RACK7_27058665_Chip-Seq_MCF-7_Human1.15139121
84* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.14777530
85TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14455588
86BCOR_27268052_Chip-Seq_Bcells_Human1.13810388
87FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.13754529
88PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13257950
89SRY_22984422_ChIP-ChIP_TESTIS_Rat1.13161704
90HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.12472320
91POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.10009468
92BRD4_27068464_Chip-Seq_AML-cells_Mouse1.09766720
93VDR_24763502_ChIP-Seq_THP-1_Human1.09670539
94THAP11_20581084_ChIP-Seq_MESCs_Mouse1.09301532
95ELK3_25401928_ChIP-Seq_HUVEC_Human1.08142657
96BCL6_27268052_Chip-Seq_Bcells_Human1.06949344
97RUNX1_22412390_ChIP-Seq_EML_Mouse1.05964678
98STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.04760634
99PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03167331
100MYB_26560356_Chip-Seq_TH2_Human1.02775010
101YY1_21170310_ChIP-Seq_MESCs_Mouse1.02684572
102HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.02194069
103IRF8_21731497_ChIP-ChIP_J774_Mouse1.01559649
104NCOR1_26117541_ChIP-Seq_K562_Human1.01429558
105STAT4_19710469_ChIP-ChIP_TH1__Mouse1.01154274
106BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.00831869
107ATF3_27146783_Chip-Seq_COLON_Human0.99924412
108STAT1_20625510_ChIP-Seq_HELA_Human0.99486855
109GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99221221
110PPARA_22158963_ChIP-Seq_LIVER_Mouse0.98584100
111CTCF_18555785_ChIP-Seq_MESCs_Mouse0.98415405
112ZNF263_19887448_ChIP-Seq_K562_Human0.97969995
113GATA1_22383799_ChIP-Seq_G1ME_Mouse0.97811625
114* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.97647597
115ELK1_22589737_ChIP-Seq_MCF10A_Human0.96130618
116MYB_26560356_Chip-Seq_TH1_Human0.96041914
117* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.95800705
118E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.95183496
119HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.94973140
120CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.93180059
121SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.92838156
122CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.92687660
123STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.92364909
124ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.91408875
125KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.90051452
126* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.89725233
127GATA2_22383799_ChIP-Seq_G1ME_Mouse0.89700635
128TP63_19390658_ChIP-ChIP_HaCaT_Human0.88605404

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.67145077
2MP0005058_abnormal_lysosome_morphology3.20010498
3MP0010352_gastrointestinal_tract_polyps2.91119188
4MP0004957_abnormal_blastocyst_morpholog2.84770874
5MP0009840_abnormal_foam_cell2.78638026
6MP0005451_abnormal_body_composition2.73178753
7MP0003111_abnormal_nucleus_morphology2.44383059
8MP0000490_abnormal_crypts_of2.43493698
9MP0010094_abnormal_chromosome_stability2.39283381
10MP0003077_abnormal_cell_cycle2.38127741
11MP0002139_abnormal_hepatobiliary_system2.33056038
12MP0003705_abnormal_hypodermis_morpholog2.31456892
13MP0006054_spinal_hemorrhage1.97941530
14MP0009333_abnormal_splenocyte_physiolog1.92219580
15MP0006082_CNS_inflammation1.91499540
16MP0002396_abnormal_hematopoietic_system1.90610900
17MP0010234_abnormal_vibrissa_follicle1.82628681
18MP0003191_abnormal_cellular_cholesterol1.81790137
19MP0002877_abnormal_melanocyte_morpholog1.80827028
20MP0005076_abnormal_cell_differentiation1.80281795
21MP0008007_abnormal_cellular_replicative1.78338135
22MP0001835_abnormal_antigen_presentation1.77936046
23MP0010307_abnormal_tumor_latency1.75052270
24MP0001873_stomach_inflammation1.68925999
25MP0003436_decreased_susceptibility_to1.68571137
26MP0010155_abnormal_intestine_physiology1.68275234
27MP0002166_altered_tumor_susceptibility1.66917037
28MP0000858_altered_metastatic_potential1.63830534
29MP0000685_abnormal_immune_system1.61772336
30MP0003763_abnormal_thymus_physiology1.59666309
31MP0009764_decreased_sensitivity_to1.58480539
32MP0000350_abnormal_cell_proliferation1.57281750
33MP0000343_altered_response_to1.54837638
34MP0008057_abnormal_DNA_replication1.54739078
35MP0003300_gastrointestinal_ulcer1.54028080
36MP0005083_abnormal_biliary_tract1.51688448
37MP0001730_embryonic_growth_arrest1.48575005
38MP0003075_altered_response_to1.46890839
39MP0003866_abnormal_defecation1.44401799
40MP0003950_abnormal_plasma_membrane1.44021131
41MP0008932_abnormal_embryonic_tissue1.43732004
42MP0008875_abnormal_xenobiotic_pharmacok1.43528289
43MP0003566_abnormal_cell_adhesion1.42542851
44MP0006036_abnormal_mitochondrial_physio1.39933991
45MP0004264_abnormal_extraembryonic_tissu1.39233365
46MP0008058_abnormal_DNA_repair1.38764307
47MP0002398_abnormal_bone_marrow1.38366987
48MP0002006_tumorigenesis1.38057249
49MP0003303_peritoneal_inflammation1.36504859
50MP0005023_abnormal_wound_healing1.35116289
51MP0002019_abnormal_tumor_incidence1.34935249
52MP0001800_abnormal_humoral_immune1.34289509
53MP0008469_abnormal_protein_level1.33489215
54MP0009785_altered_susceptibility_to1.33456496
55MP0002254_reproductive_system_inflammat1.32187331
56MP0005165_increased_susceptibility_to1.31519656
57MP0002452_abnormal_antigen_presenting1.30779119
58MP0003123_paternal_imprinting1.29333095
59MP0005671_abnormal_response_to1.29161722
60MP0004808_abnormal_hematopoietic_stem1.26473071
61MP0001819_abnormal_immune_cell1.25255281
62MP0002405_respiratory_system_inflammati1.25247606
63MP0002722_abnormal_immune_system1.25186106
64MP0002420_abnormal_adaptive_immunity1.24710097
65MP0005000_abnormal_immune_tolerance1.24501684
66MP0003656_abnormal_erythrocyte_physiolo1.23867958
67MP0005025_abnormal_response_to1.22207696
68MP0002148_abnormal_hypersensitivity_rea1.18546470
69MP0000477_abnormal_intestine_morphology1.18330363
70MP0001545_abnormal_hematopoietic_system1.17537063
71MP0005397_hematopoietic_system_phenotyp1.17537063
72MP0001881_abnormal_mammary_gland1.17026818
73MP0005365_abnormal_bile_salt1.16760158
74MP0004947_skin_inflammation1.15131632
75MP0002429_abnormal_blood_cell1.13256555
76MP0002723_abnormal_immune_serum1.13183614
77MP0000689_abnormal_spleen_morphology1.12731471
78MP0008438_abnormal_cutaneous_collagen1.10881613
79MP0000716_abnormal_immune_system1.10517941
80MP0000703_abnormal_thymus_morphology1.10017275
81MP0001697_abnormal_embryo_size1.09908662
82MP0002080_prenatal_lethality1.08996929
83MP0000537_abnormal_urethra_morphology1.08420008
84MP0005387_immune_system_phenotype1.08347484
85MP0001790_abnormal_immune_system1.08347484
86MP0001845_abnormal_inflammatory_respons1.06404825
87MP0000313_abnormal_cell_death1.05147519
88MP0002086_abnormal_extraembryonic_tissu1.04262104
89MP0005319_abnormal_enzyme/_coenzyme1.03295961
90MP0001542_abnormal_bone_strength1.02576437
91MP0005380_embryogenesis_phenotype1.02410974
92MP0001672_abnormal_embryogenesis/_devel1.02410974
93MP0003718_maternal_effect1.01367925
94MP0001727_abnormal_embryo_implantation1.01046352
95MP0000465_gastrointestinal_hemorrhage1.00916212
96MP0004197_abnormal_fetal_growth/weight/1.00183997
97MP0003448_altered_tumor_morphology0.99970438
98MP0008260_abnormal_autophagy0.99260397
99MP0003984_embryonic_growth_retardation0.98688356
100MP0002088_abnormal_embryonic_growth/wei0.96781499
101MP0004510_myositis0.96427109
102MP0001764_abnormal_homeostasis0.96211768
103MP0001849_ear_inflammation0.94003266
104MP0009379_abnormal_foot_pigmentation0.92717112
105MP0002419_abnormal_innate_immunity0.92171619
106MP0005220_abnormal_exocrine_pancreas0.92103966
107MP0005310_abnormal_salivary_gland0.91663079
108MP0001663_abnormal_digestive_system0.90510228
109MP0009643_abnormal_urine_homeostasis0.90272026
110MP0005464_abnormal_platelet_physiology0.89726449
111MP0009763_increased_sensitivity_to0.88893967
112MP0000609_abnormal_liver_physiology0.88169794
113MP0000678_abnormal_parathyroid_gland0.87375695
114MP0003453_abnormal_keratinocyte_physiol0.87284450
115MP0003786_premature_aging0.86852211
116MP0002085_abnormal_embryonic_tissue0.86529512
117MP0006035_abnormal_mitochondrial_morpho0.86312426
118MP0002332_abnormal_exercise_endurance0.85901779
119MP0003172_abnormal_lysosome_physiology0.85374253
120MP0005360_urolithiasis0.85367000
121MP0003567_abnormal_fetal_cardiomyocyte0.83902203
122MP0003724_increased_susceptibility_to0.83363242
123MP0003186_abnormal_redox_activity0.83287497
124MP0001533_abnormal_skeleton_physiology0.82668563
125MP0005166_decreased_susceptibility_to0.81826816
126MP0003806_abnormal_nucleotide_metabolis0.81413541
127MP0009278_abnormal_bone_marrow0.80940230
128MP0002277_abnormal_respiratory_mucosa0.80820403
129MP0002132_abnormal_respiratory_system0.79979096
130MP0000358_abnormal_cell_content/0.78952139
131MP0004043_abnormal_pH_regulation0.78183657
132MP0002084_abnormal_developmental_patter0.75719546
133MP0001243_abnormal_dermal_layer0.73502055
134MP0001853_heart_inflammation0.73401411
135MP0005501_abnormal_skin_physiology0.72851239
136MP0009053_abnormal_anal_canal0.72835510
137MP0005381_digestive/alimentary_phenotyp0.71433395
138MP0002060_abnormal_skin_morphology0.71231873

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)5.15000986
2Abnormality of liposaccharide metabolism (HP:0010968)5.15000986
3Abnormality of glycosphingolipid metabolism (HP:0004343)5.15000986
4Reticulocytopenia (HP:0001896)4.48150477
5Abnormality of cells of the erythroid lineage (HP:0012130)4.03956142
6Thrombocytosis (HP:0001894)3.73286313
7Abnormal number of erythroid precursors (HP:0012131)3.70913179
8Increased cerebral lipofuscin (HP:0011813)3.32244994
9Increased neuronal autofluorescent lipopigment (HP:0002074)3.09628645
10Dysostosis multiplex (HP:0000943)2.91930242
11Pallor (HP:0000980)2.89703382
12Trismus (HP:0000211)2.81957812
13Degeneration of anterior horn cells (HP:0002398)2.76327577
14Abnormality of the anterior horn cell (HP:0006802)2.76327577
15Aplastic anemia (HP:0001915)2.73747655
16Hypertensive crisis (HP:0100735)2.72793679
1711 pairs of ribs (HP:0000878)2.71784973
18Multiple enchondromatosis (HP:0005701)2.70200662
19Abnormal mitochondria in muscle tissue (HP:0008316)2.65998191
20Systemic lupus erythematosus (HP:0002725)2.65551415
21Increased serum ferritin (HP:0003281)2.63823935
22Macrocytic anemia (HP:0001972)2.63560196
23Elevated erythrocyte sedimentation rate (HP:0003565)2.61239934
24Colon cancer (HP:0003003)2.60625387
25Decreased activity of mitochondrial respiratory chain (HP:0008972)2.60481090
26Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.60481090
27Ragged-red muscle fibers (HP:0003200)2.60041127
28Nausea (HP:0002018)2.58983490
29Increased CSF lactate (HP:0002490)2.54605724
30Abnormality of T cell physiology (HP:0011840)2.52256898
31Hepatosplenomegaly (HP:0001433)2.50489425
32Acute necrotizing encephalopathy (HP:0006965)2.48222735
33Pustule (HP:0200039)2.47082796
34Selective tooth agenesis (HP:0001592)2.43931667
35Esophageal neoplasm (HP:0100751)2.42237869
36Neoplasm of head and neck (HP:0012288)2.42237869
37Microretrognathia (HP:0000308)2.38593967
38Mitochondrial inheritance (HP:0001427)2.38143937
39Acute encephalopathy (HP:0006846)2.37953724
40Microvesicular hepatic steatosis (HP:0001414)2.37763985
41Petechiae (HP:0000967)2.36759062
42Increased serum pyruvate (HP:0003542)2.33570558
43Axonal loss (HP:0003447)2.33262127
44Hepatocellular necrosis (HP:0001404)2.32577637
45Prolonged neonatal jaundice (HP:0006579)2.31365255
46Hepatic necrosis (HP:0002605)2.31037372
47Testicular atrophy (HP:0000029)2.30600243
48Loss of speech (HP:0002371)2.28441345
49Abnormal trabecular bone morphology (HP:0100671)2.25405709
50Eczematoid dermatitis (HP:0000976)2.25035537
51Aplasia/Hypoplasia of the sacrum (HP:0008517)2.24106385
52Increased serum lactate (HP:0002151)2.23227814
53IgM deficiency (HP:0002850)2.21837456
54Abnormality of glycolysis (HP:0004366)2.20598573
55Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.19919470
56Breast hypoplasia (HP:0003187)2.15398886
57Cervical subluxation (HP:0003308)2.15079909
58Abnormal gallbladder physiology (HP:0012438)2.14803501
59Cholecystitis (HP:0001082)2.14803501
60Missing ribs (HP:0000921)2.14179478
61Deviation of the thumb (HP:0009603)2.13318481
62Obstructive lung disease (HP:0006536)2.12593596
63Chronic obstructive pulmonary disease (HP:0006510)2.12593596
64Abnormality of polysaccharide metabolism (HP:0011012)2.10542848
65Abnormality of glycosaminoglycan metabolism (HP:0004371)2.10542848
66Abnormality of mucopolysaccharide metabolism (HP:0011020)2.10542848
67Ileus (HP:0002595)2.10377405
68Abnormality of macrophages (HP:0004311)2.09492200
69Lactic acidosis (HP:0003128)2.08076370
70Autoimmune hemolytic anemia (HP:0001890)2.07492733
71Abnormality of T cells (HP:0002843)2.07227635
72Recurrent viral infections (HP:0004429)2.02385945
73Abnormality of the calcaneus (HP:0008364)1.99550892
74Abnormality of iron homeostasis (HP:0011031)1.99491915
75Neoplasm of the pancreas (HP:0002894)1.98264331
76Micronodular cirrhosis (HP:0001413)1.97173275
77Cerebral edema (HP:0002181)1.96870050
78Basal cell carcinoma (HP:0002671)1.94674078
79Mediastinal lymphadenopathy (HP:0100721)1.94219781
80Proximal placement of thumb (HP:0009623)1.94181904
81Increased intramyocellular lipid droplets (HP:0012240)1.93043865
82Opisthotonus (HP:0002179)1.92262946
83Type I transferrin isoform profile (HP:0003642)1.91932083
84Recurrent abscess formation (HP:0002722)1.90653455
85Cellulitis (HP:0100658)1.90318406
86Myocardial infarction (HP:0001658)1.89183436
87Abnormality of reticulocytes (HP:0004312)1.88961443
88Recurrent fungal infections (HP:0002841)1.88932369
89Mucopolysacchariduria (HP:0008155)1.88876145
90Urinary glycosaminoglycan excretion (HP:0003541)1.88876145
91Rough bone trabeculation (HP:0100670)1.87499496
92Respiratory failure (HP:0002878)1.85355727
93Oral leukoplakia (HP:0002745)1.84952359
94Carpal bone hypoplasia (HP:0001498)1.84396502
95Abnormal delayed hypersensitivity skin test (HP:0002963)1.81762338
96Abnormality of transition element cation homeostasis (HP:0011030)1.81550276
97Generalized aminoaciduria (HP:0002909)1.80926737
98Increased muscle lipid content (HP:0009058)1.79244911
99Abnormality of monocarboxylic acid metabolism (HP:0010996)1.79001829
100Nuclear cataract (HP:0100018)1.77552113
101Abnormality of dicarboxylic acid metabolism (HP:0010995)1.77307210
102Dicarboxylic aciduria (HP:0003215)1.77307210
103Birth length less than 3rd percentile (HP:0003561)1.77305286
104Hypokinesia (HP:0002375)1.77127981
105Ependymoma (HP:0002888)1.76819958
106Abnormal foot bone ossification (HP:0010675)1.76390039
107Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.75736318
108Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.75169305
109Abnormality of the umbilical cord (HP:0010881)1.74766027
110Glossoptosis (HP:0000162)1.74234397
111Absent thumb (HP:0009777)1.74067702
112Entropion (HP:0000621)1.73800325
113Increased density of long bones (HP:0006392)1.73516218
114J-shaped sella turcica (HP:0002680)1.73505420
115Abnormality of the nasal mucosa (HP:0000433)1.72852876
116Patellar aplasia (HP:0006443)1.71682662
117Vertebral hypoplasia (HP:0008417)1.71482818
118Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.71482818
119Pancytopenia (HP:0001876)1.71461006
120Congenital ichthyosiform erythroderma (HP:0007431)1.70711615
121Amaurosis fugax (HP:0100576)1.70520389
122Purpura (HP:0000979)1.70463813
123Recurrent bacterial skin infections (HP:0005406)1.70110120
124Abnormal protein glycosylation (HP:0012346)1.69720069
125Abnormal glycosylation (HP:0012345)1.69720069
126Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.69720069
127Abnormal protein N-linked glycosylation (HP:0012347)1.69720069
128Myelodysplasia (HP:0002863)1.68772723
129Protrusio acetabuli (HP:0003179)1.68407407
130Nonimmune hydrops fetalis (HP:0001790)1.67780988
131Abnormality of subcutaneous fat tissue (HP:0001001)1.67448602
132Autoimmune thrombocytopenia (HP:0001973)1.66499762
133Poikiloderma (HP:0001029)1.65938946
134Hyperammonemia (HP:0001987)1.65902535
135Short nail (HP:0001799)1.65749372
136Lethargy (HP:0001254)1.65720275
137Agnosia (HP:0010524)1.65713316
138Aplasia/Hypoplasia of the patella (HP:0006498)1.62993043
139Poor head control (HP:0002421)1.62530862
140Hypoplasia of the pons (HP:0012110)1.61816474
141Reduced antithrombin III activity (HP:0001976)1.61585478
142Vacuolated lymphocytes (HP:0001922)1.60286770
143Peritonitis (HP:0002586)1.60222957
144Ureteral stenosis (HP:0000071)1.59697642
145Myositis (HP:0100614)1.58740814
146IgA deficiency (HP:0002720)1.58162452
147High pitched voice (HP:0001620)1.57774356
148Verrucae (HP:0200043)1.57686295
149Papilloma (HP:0012740)1.57686295
150Chromsome breakage (HP:0040012)1.57289539
151Premature graying of hair (HP:0002216)1.56481424
152Adenoma sebaceum (HP:0009720)1.56158226
153Angiofibromas (HP:0010615)1.56158226
154Abnormal hemoglobin (HP:0011902)1.54632371
155Biliary tract neoplasm (HP:0100574)1.53536461
156Interstitial pulmonary disease (HP:0006530)1.53168998
157Rectal prolapse (HP:0002035)1.52997802
158Periodontitis (HP:0000704)1.52971516
159Progressive muscle weakness (HP:0003323)1.52665964
160Vertebral compression fractures (HP:0002953)1.52627693
161Skin ulcer (HP:0200042)1.52376086
162Gastrointestinal dysmotility (HP:0002579)1.52193471
163Lymphoma (HP:0002665)1.52080237
164Spinal cord compression (HP:0002176)1.51950824
165Recurrent bronchitis (HP:0002837)1.50920614
166Ureteral obstruction (HP:0006000)1.50848760
167Severe short stature (HP:0003510)1.50581125
168Abnormal platelet volume (HP:0011876)1.50500701
169Gastrointestinal inflammation (HP:0004386)1.50059975
170Ulnar deviation of the wrist (HP:0003049)1.49844626
171Radial bowing (HP:0002986)1.49424181
172Abnormality of T cell number (HP:0011839)1.48723917
173Abnormality of the distal phalanges of the toes (HP:0010182)1.48511840
174Hand muscle atrophy (HP:0009130)1.48091645

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME23.57622245
2VRK23.11275999
3EEF2K2.96258985
4PKN22.45765757
5MAP3K102.44414190
6TRIB32.33713761
7TESK22.31407514
8PBK2.30066256
9TESK12.25937775
10BUB12.22324431
11CDC72.18288032
12RPS6KB22.17374220
13ERN12.15521642
14PDK22.14305583
15TLK12.14271405
16SMG12.01365519
17SCYL21.94520537
18EIF2AK11.84300677
19PIM21.79944718
20PASK1.79825766
21TAOK21.75470428
22LRRK21.73538051
23MAP4K11.73467734
24RPS6KA41.73383027
25NEK21.73349461
26WEE11.71374735
27ABL21.66739403
28STK101.63236861
29MAPKAPK31.62689061
30ARAF1.56336637
31EIF2AK31.55138365
32MAP3K81.38794938
33BLK1.38012523
34EPHA21.34031369
35FLT31.31073330
36MST41.27772220
37PAK41.26651726
38AURKB1.23983649
39KDR1.18193796
40SRPK11.18155956
41PTK61.18151062
42MAP3K111.15818445
43JAK31.14782460
44TTK1.14331999
45CDK121.13630324
46LIMK11.13428868
47TYK21.12322437
48BMPR21.12247069
49CDK71.10850411
50GRK71.10028147
51ZAP701.10002853
52MAP3K31.07755440
53MAP2K31.07483150
54IRAK41.03496383
55PIM11.02982527
56MAP2K20.99220924
57CDK40.98205723
58PLK10.95789460
59CCNB10.95002002
60TBK10.94806586
61TGFBR10.94443562
62IKBKE0.93810369
63BRSK20.91112714
64NEK10.89755632
65ATR0.87820572
66MATK0.87186256
67GRK60.86775135
68BTK0.86496311
69VRK10.85190393
70DYRK30.82636794
71STK40.81109335
72ICK0.80093985
73TTN0.79192156
74BRAF0.78333122
75ILK0.75945815
76AURKA0.74860053
77RIPK40.74138957
78CLK10.72638214
79MAP3K120.72162815
80BCKDK0.71042903
81PLK40.70347566
82ACVR1B0.70092373
83DAPK10.69719247
84PAK10.69610392
85MAPKAPK50.66894512
86IKBKB0.65299279
87PAK20.64286248
88MAPK110.64247310
89TSSK60.64101225
90TEC0.63811454
91CHEK20.61288699
92PRKCI0.60805881
93CDK60.59830696
94TRPM70.59078291
95CAMKK20.59045320
96CDK80.58840281
97CHEK10.56343418
98MAPKAPK20.55906231
99MAP3K140.55415600
100MOS0.55330891
101STK160.55189317
102CHUK0.55135524
103IRAK30.54907582
104DAPK30.54330837
105ADRBK20.54250350
106TGFBR20.52937698
107BMX0.52749665
108KIT0.52200739
109FRK0.51814265
110ZAK0.51715945
111NEK90.51523010
112RIPK10.51515140
113NUAK10.49538054
114PRKG20.48677905
115NME10.46886945
116CSF1R0.46233715
117ITK0.45626898
118MST1R0.42706652
119ALK0.42626671
120CSK0.42576458
121MYLK0.41851642
122IRAK10.40932446
123CSNK2A20.40868893
124TAOK30.40802313
125EIF2AK20.40311099
126LMTK20.39732014
127LCK0.39646225
128ATM0.39455669
129RPS6KC10.39396920
130RPS6KL10.39396920
131BRSK10.38974752
132STK30.38954726
133PRPF4B0.37873789
134RPS6KA50.37603607
135CDC42BPA0.37174790
136MUSK0.37016110
137CSNK2A10.36384730
138DDR20.36277583
139RAF10.35538156

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.11203937
2DNA replication_Homo sapiens_hsa030304.10578039
3Mismatch repair_Homo sapiens_hsa034303.21364654
4Base excision repair_Homo sapiens_hsa034102.53607285
5Proteasome_Homo sapiens_hsa030502.40057724
6One carbon pool by folate_Homo sapiens_hsa006702.30224241
7Spliceosome_Homo sapiens_hsa030402.29640208
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.11854082
9Homologous recombination_Homo sapiens_hsa034402.06976767
10RNA transport_Homo sapiens_hsa030132.04973470
11Protein export_Homo sapiens_hsa030602.02046444
12Nucleotide excision repair_Homo sapiens_hsa034201.96562437
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.90198037
14Cell cycle_Homo sapiens_hsa041101.83900261
15Oxidative phosphorylation_Homo sapiens_hsa001901.81226665
16Pyrimidine metabolism_Homo sapiens_hsa002401.76505532
17Lysosome_Homo sapiens_hsa041421.75152924
18Antigen processing and presentation_Homo sapiens_hsa046121.73634405
19Asthma_Homo sapiens_hsa053101.70634457
20RNA polymerase_Homo sapiens_hsa030201.70568846
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.61609832
22Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.58196078
23p53 signaling pathway_Homo sapiens_hsa041151.52460510
24Rheumatoid arthritis_Homo sapiens_hsa053231.43973259
25Parkinsons disease_Homo sapiens_hsa050121.41592816
26* Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.35380909
27Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.32381508
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.27821602
29Non-homologous end-joining_Homo sapiens_hsa034501.26354021
30Legionellosis_Homo sapiens_hsa051341.25982408
31Systemic lupus erythematosus_Homo sapiens_hsa053221.24181350
32N-Glycan biosynthesis_Homo sapiens_hsa005101.22581878
33Huntingtons disease_Homo sapiens_hsa050161.22484037
34Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.19731859
35Leishmaniasis_Homo sapiens_hsa051401.18592518
36Viral carcinogenesis_Homo sapiens_hsa052031.18384694
37Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.14206588
38Fanconi anemia pathway_Homo sapiens_hsa034601.12422866
39Primary immunodeficiency_Homo sapiens_hsa053401.12141742
40Herpes simplex infection_Homo sapiens_hsa051681.12028427
41Epstein-Barr virus infection_Homo sapiens_hsa051691.06020963
42Apoptosis_Homo sapiens_hsa042101.04982961
43Intestinal immune network for IgA production_Homo sapiens_hsa046721.04258111
44Sulfur relay system_Homo sapiens_hsa041221.03210956
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.02546119
46RNA degradation_Homo sapiens_hsa030181.02472342
47Autoimmune thyroid disease_Homo sapiens_hsa053200.98982715
48Measles_Homo sapiens_hsa051620.98877365
49Folate biosynthesis_Homo sapiens_hsa007900.96931255
50NF-kappa B signaling pathway_Homo sapiens_hsa040640.96926452
51Small cell lung cancer_Homo sapiens_hsa052220.95509387
52Thyroid cancer_Homo sapiens_hsa052160.91464162
53Shigellosis_Homo sapiens_hsa051310.91344237
54mRNA surveillance pathway_Homo sapiens_hsa030150.87642573
55Bladder cancer_Homo sapiens_hsa052190.87094427
56Staphylococcus aureus infection_Homo sapiens_hsa051500.86032195
57HTLV-I infection_Homo sapiens_hsa051660.84778144
58Vibrio cholerae infection_Homo sapiens_hsa051100.84472989
59Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.84144043
60Galactose metabolism_Homo sapiens_hsa000520.83438585
61Alzheimers disease_Homo sapiens_hsa050100.83382449
62Cysteine and methionine metabolism_Homo sapiens_hsa002700.83274735
63Carbon metabolism_Homo sapiens_hsa012000.83110788
64Pentose phosphate pathway_Homo sapiens_hsa000300.82396930
65Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.82055818
66Selenocompound metabolism_Homo sapiens_hsa004500.81828274
67Other glycan degradation_Homo sapiens_hsa005110.81587990
68Maturity onset diabetes of the young_Homo sapiens_hsa049500.81429695
69Chronic myeloid leukemia_Homo sapiens_hsa052200.80566462
70Fatty acid elongation_Homo sapiens_hsa000620.79272036
71Influenza A_Homo sapiens_hsa051640.79255738
72Viral myocarditis_Homo sapiens_hsa054160.77188633
73RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.76780536
74Pyruvate metabolism_Homo sapiens_hsa006200.75014176
75Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.73910424
76Hepatitis B_Homo sapiens_hsa051610.73838569
77Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.71133318
78Toxoplasmosis_Homo sapiens_hsa051450.70585710
79Leukocyte transendothelial migration_Homo sapiens_hsa046700.70216345
80Allograft rejection_Homo sapiens_hsa053300.69813198
81Renin-angiotensin system_Homo sapiens_hsa046140.69258397
82Acute myeloid leukemia_Homo sapiens_hsa052210.68809911
83Sphingolipid metabolism_Homo sapiens_hsa006000.68227028
84Cyanoamino acid metabolism_Homo sapiens_hsa004600.63611033
85SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62708026
86Hematopoietic cell lineage_Homo sapiens_hsa046400.62500885
87Purine metabolism_Homo sapiens_hsa002300.61471715
88Basal transcription factors_Homo sapiens_hsa030220.60324286
89MicroRNAs in cancer_Homo sapiens_hsa052060.59639964
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59633207
91Peroxisome_Homo sapiens_hsa041460.58582180
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.58434947
93Malaria_Homo sapiens_hsa051440.56810037
94* Metabolic pathways_Homo sapiens_hsa011000.56573069
95Mineral absorption_Homo sapiens_hsa049780.56568963
96Graft-versus-host disease_Homo sapiens_hsa053320.56249104
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.56194582
98Toll-like receptor signaling pathway_Homo sapiens_hsa046200.55362448
99Pertussis_Homo sapiens_hsa051330.54314198
100Hepatitis C_Homo sapiens_hsa051600.54079707
101Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52491982
102Drug metabolism - other enzymes_Homo sapiens_hsa009830.52322898
103Type I diabetes mellitus_Homo sapiens_hsa049400.51205752
104Osteoclast differentiation_Homo sapiens_hsa043800.51061202
105Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50607514
106Tryptophan metabolism_Homo sapiens_hsa003800.50561616
107Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50414777
108Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50075690
109Pancreatic cancer_Homo sapiens_hsa052120.49043169
110B cell receptor signaling pathway_Homo sapiens_hsa046620.48739491
111Jak-STAT signaling pathway_Homo sapiens_hsa046300.48489936
112TNF signaling pathway_Homo sapiens_hsa046680.47131876
113Arginine and proline metabolism_Homo sapiens_hsa003300.46467380
114Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46393342
115Phenylalanine metabolism_Homo sapiens_hsa003600.46142919
116Fructose and mannose metabolism_Homo sapiens_hsa000510.46047355
117Glutathione metabolism_Homo sapiens_hsa004800.46022657
118Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.45680480
119Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.44868014
120Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44649418
121Collecting duct acid secretion_Homo sapiens_hsa049660.44227282
122Salmonella infection_Homo sapiens_hsa051320.43726066
123Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.43635707
124Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.43510596
125HIF-1 signaling pathway_Homo sapiens_hsa040660.42957167
126Biosynthesis of amino acids_Homo sapiens_hsa012300.41262161
127Colorectal cancer_Homo sapiens_hsa052100.41205092
128Fat digestion and absorption_Homo sapiens_hsa049750.41151316
129Glycosaminoglycan degradation_Homo sapiens_hsa005310.41107849
130Tuberculosis_Homo sapiens_hsa051520.40469284
131Sulfur metabolism_Homo sapiens_hsa009200.38588507
132Adherens junction_Homo sapiens_hsa045200.36509398
133Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34205392
134Prostate cancer_Homo sapiens_hsa052150.33699636
135Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33532295
136T cell receptor signaling pathway_Homo sapiens_hsa046600.33460002

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