

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA unwinding involved in DNA replication (GO:0006268) | 5.36042208 |
| 2 | nuclear pore organization (GO:0006999) | 4.92721547 |
| 3 | nuclear pore complex assembly (GO:0051292) | 4.74217696 |
| 4 | protein localization to kinetochore (GO:0034501) | 4.68779214 |
| 5 | DNA replication initiation (GO:0006270) | 4.22147412 |
| 6 | mitotic nuclear envelope disassembly (GO:0007077) | 4.19768082 |
| 7 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.16195784 |
| 8 | mitotic metaphase plate congression (GO:0007080) | 4.14098459 |
| 9 | formation of translation preinitiation complex (GO:0001731) | 4.12042729 |
| 10 | mitotic sister chromatid cohesion (GO:0007064) | 4.10329670 |
| 11 | DNA replication-dependent nucleosome assembly (GO:0006335) | 4.06513389 |
| 12 | DNA replication-dependent nucleosome organization (GO:0034723) | 4.06513389 |
| 13 | pre-miRNA processing (GO:0031054) | 4.05414598 |
| 14 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.96188066 |
| 15 | nuclear envelope disassembly (GO:0051081) | 3.95135701 |
| 16 | membrane disassembly (GO:0030397) | 3.95135701 |
| 17 | DNA strand elongation (GO:0022616) | 3.93844682 |
| 18 | protein localization to chromosome, centromeric region (GO:0071459) | 3.92239644 |
| 19 | sister chromatid segregation (GO:0000819) | 3.89909549 |
| 20 | kinetochore organization (GO:0051383) | 3.89557856 |
| 21 | mitotic sister chromatid segregation (GO:0000070) | 3.87773871 |
| 22 | IMP biosynthetic process (GO:0006188) | 3.78699491 |
| 23 | metaphase plate congression (GO:0051310) | 3.66351075 |
| 24 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.65864992 |
| 25 | chromatin remodeling at centromere (GO:0031055) | 3.64756536 |
| 26 | DNA ligation (GO:0006266) | 3.64503343 |
| 27 | negative regulation of mRNA splicing, via spliceosome (GO:0048025) | 3.64424271 |
| 28 | mitotic chromosome condensation (GO:0007076) | 3.64103127 |
| 29 | DNA replication checkpoint (GO:0000076) | 3.63612560 |
| 30 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.60778631 |
| 31 | heterochromatin organization (GO:0070828) | 3.60688048 |
| 32 | DNA duplex unwinding (GO:0032508) | 3.59772091 |
| 33 | DNA geometric change (GO:0032392) | 3.59173536 |
| 34 | nucleobase biosynthetic process (GO:0046112) | 3.58611169 |
| 35 | DNA replication-independent nucleosome organization (GO:0034724) | 3.57589400 |
| 36 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.57589400 |
| 37 | CENP-A containing nucleosome assembly (GO:0034080) | 3.57472943 |
| 38 | ribosomal large subunit biogenesis (GO:0042273) | 3.56604434 |
| 39 | ribosome assembly (GO:0042255) | 3.52444449 |
| 40 | pore complex assembly (GO:0046931) | 3.52266202 |
| 41 | mitotic recombination (GO:0006312) | 3.46715501 |
| 42 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 3.46546475 |
| 43 | regulation of spindle organization (GO:0090224) | 3.46198278 |
| 44 | maturation of SSU-rRNA (GO:0030490) | 3.44802623 |
| 45 | non-recombinational repair (GO:0000726) | 3.44236080 |
| 46 | double-strand break repair via nonhomologous end joining (GO:0006303) | 3.44236080 |
| 47 | mitotic G2/M transition checkpoint (GO:0044818) | 3.43772944 |
| 48 | attachment of spindle microtubules to kinetochore (GO:0008608) | 3.39661095 |
| 49 | negative regulation of RNA splicing (GO:0033119) | 3.38647642 |
| 50 | telomere maintenance via recombination (GO:0000722) | 3.36788902 |
| 51 | positive regulation of chromosome segregation (GO:0051984) | 3.35741434 |
| 52 | paraxial mesoderm development (GO:0048339) | 3.33388011 |
| 53 | histone exchange (GO:0043486) | 3.32060478 |
| 54 | IMP metabolic process (GO:0046040) | 3.31014735 |
| 55 | regulation of gene silencing by RNA (GO:0060966) | 3.30595954 |
| 56 | regulation of posttranscriptional gene silencing (GO:0060147) | 3.30595954 |
| 57 | regulation of gene silencing by miRNA (GO:0060964) | 3.30595954 |
| 58 | establishment of chromosome localization (GO:0051303) | 3.30035559 |
| 59 | regulation of sister chromatid cohesion (GO:0007063) | 3.29353091 |
| 60 | kinetochore assembly (GO:0051382) | 3.29233127 |
| 61 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 3.28835563 |
| 62 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 3.28634877 |
| 63 | negative regulation of histone methylation (GO:0031061) | 3.28215738 |
| 64 | regulation of centrosome cycle (GO:0046605) | 3.25959195 |
| 65 | purine nucleobase biosynthetic process (GO:0009113) | 3.22803992 |
| 66 | regulation of chromosome segregation (GO:0051983) | 3.20244123 |
| 67 | chromatin assembly or disassembly (GO:0006333) | 3.18998614 |
| 68 | negative regulation of mRNA processing (GO:0050686) | 3.18439913 |
| 69 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377) | 3.17726081 |
| 70 | mRNA splicing, via spliceosome (GO:0000398) | 3.17726081 |
| 71 | RNA splicing, via transesterification reactions (GO:0000375) | 3.17645118 |
| 72 | spindle checkpoint (GO:0031577) | 3.17198680 |
| 73 | dosage compensation (GO:0007549) | 3.16693652 |
| 74 | regulation of centriole replication (GO:0046599) | 3.15497030 |
| 75 | negative regulation of chromosome segregation (GO:0051985) | 3.15185643 |
| 76 | telomere maintenance via telomere lengthening (GO:0010833) | 3.15059791 |
| 77 | ATP-dependent chromatin remodeling (GO:0043044) | 3.14752317 |
| 78 | regulation of mitotic metaphase/anaphase transition (GO:0030071) | 3.12327820 |
| 79 | negative regulation of mRNA metabolic process (GO:1903312) | 3.11398085 |
| 80 | regulation of histone H3-K9 methylation (GO:0051570) | 3.11372692 |
| 81 | spindle assembly checkpoint (GO:0071173) | 3.11269030 |
| 82 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 3.10962939 |
| 83 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 3.10962939 |
| 84 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 3.10962939 |
| 85 | negative regulation of sister chromatid segregation (GO:0033046) | 3.10962939 |
| 86 | positive regulation of mitotic metaphase/anaphase transition (GO:0045842) | 3.10576667 |
| 87 | positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101) | 3.10576667 |
| 88 | positive regulation of mitotic sister chromatid separation (GO:1901970) | 3.10576667 |
| 89 | regulation of RNA export from nucleus (GO:0046831) | 3.10486032 |
| 90 | protein localization to chromosome (GO:0034502) | 3.10123206 |
| 91 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 3.09955306 |
| 92 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 3.09955306 |
| 93 | mitotic spindle assembly checkpoint (GO:0007094) | 3.07859813 |
| 94 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.07743777 |
| 95 | mitotic spindle checkpoint (GO:0071174) | 3.06386605 |
| 96 | ribosomal small subunit assembly (GO:0000028) | 3.06243642 |
| 97 | peptidyl-arginine omega-N-methylation (GO:0035247) | 3.05834597 |
| 98 | regulation of mitotic sister chromatid separation (GO:0010965) | 3.05822373 |
| 99 | regulation of sister chromatid segregation (GO:0033045) | 3.05822373 |
| 100 | ribosome biogenesis (GO:0042254) | 3.04897657 |
| 101 | regulation of metaphase/anaphase transition of cell cycle (GO:1902099) | 3.04556927 |
| 102 | nuclear envelope organization (GO:0006998) | 3.04371174 |
| 103 | regulation of mitotic spindle organization (GO:0060236) | 3.03873939 |
| 104 | DNA double-strand break processing (GO:0000729) | 3.03754374 |
| 105 | DNA topological change (GO:0006265) | 3.02405229 |
| 106 | negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100) | 3.00946634 |
| 107 | translational initiation (GO:0006413) | 3.00743018 |
| 108 | establishment of integrated proviral latency (GO:0075713) | 3.00051175 |
| 109 | regulation of DNA endoreduplication (GO:0032875) | 2.98610222 |
| 110 | DNA strand renaturation (GO:0000733) | 2.97993327 |
| 111 | regulation of mitotic sister chromatid segregation (GO:0033047) | 2.97756957 |
| 112 | sister chromatid cohesion (GO:0007062) | 2.97550453 |
| 113 | translational termination (GO:0006415) | 2.97260747 |
| 114 | establishment of viral latency (GO:0019043) | 2.96498939 |
| 115 | viral transcription (GO:0019083) | 2.92258752 |
| 116 | ribosomal small subunit biogenesis (GO:0042274) | 2.87442228 |
| 117 | mitotic G2 DNA damage checkpoint (GO:0007095) | 2.87133386 |
| 118 | regulation of helicase activity (GO:0051095) | 2.86931125 |
| 119 | V(D)J recombination (GO:0033151) | 2.83244308 |
| 120 | regulation of centrosome duplication (GO:0010824) | 2.80356121 |
| 121 | termination of RNA polymerase II transcription (GO:0006369) | 2.79687403 |
| 122 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 2.78204267 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 5.22200500 |
| 2 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.44524243 |
| 3 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 4.28974798 |
| 4 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 3.41829856 |
| 5 | * EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.37895031 |
| 6 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 3.27954987 |
| 7 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 3.04530410 |
| 8 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.82645892 |
| 9 | * KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 2.71347111 |
| 10 | AR_21909140_ChIP-Seq_LNCAP_Human | 2.54276079 |
| 11 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.48497499 |
| 12 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.41021290 |
| 13 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.39867532 |
| 14 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.37656003 |
| 15 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 2.37508886 |
| 16 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.36993801 |
| 17 | * EWS_26573619_Chip-Seq_HEK293_Human | 2.21284527 |
| 18 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.18945864 |
| 19 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 2.14763727 |
| 20 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.11716863 |
| 21 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.08267005 |
| 22 | FUS_26573619_Chip-Seq_HEK293_Human | 2.04192697 |
| 23 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 2.02561990 |
| 24 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.02293547 |
| 25 | * MYC_22102868_ChIP-Seq_BL_Human | 2.00479925 |
| 26 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 2.00321449 |
| 27 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 2.00315285 |
| 28 | E2F7_22180533_ChIP-Seq_HELA_Human | 10.3125793 |
| 29 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 1.96387641 |
| 30 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.89682886 |
| 31 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.89507836 |
| 32 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.83502681 |
| 33 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.82870989 |
| 34 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.82085385 |
| 35 | * VDR_23849224_ChIP-Seq_CD4+_Human | 1.78114589 |
| 36 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.77728607 |
| 37 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.77117030 |
| 38 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 1.73474903 |
| 39 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.68603777 |
| 40 | * ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.66835785 |
| 41 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.65291522 |
| 42 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.64657470 |
| 43 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.62466494 |
| 44 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.62401924 |
| 45 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.61535750 |
| 46 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.57857256 |
| 47 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.53449566 |
| 48 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.53067153 |
| 49 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.52212632 |
| 50 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.50635122 |
| 51 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.49012687 |
| 52 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.46892946 |
| 53 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.46310275 |
| 54 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.44910991 |
| 55 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.42867451 |
| 56 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.37234868 |
| 57 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.36233328 |
| 58 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 1.33773848 |
| 59 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.31319147 |
| 60 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.29209093 |
| 61 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.28778981 |
| 62 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.28134807 |
| 63 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.27494978 |
| 64 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.27457123 |
| 65 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.26559342 |
| 66 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 1.26127971 |
| 67 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.25510659 |
| 68 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.24008342 |
| 69 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.23753149 |
| 70 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.23083767 |
| 71 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.23063377 |
| 72 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.22233583 |
| 73 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.21425531 |
| 74 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.20855025 |
| 75 | * PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.19904652 |
| 76 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 1.19478066 |
| 77 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 1.19437754 |
| 78 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.16858344 |
| 79 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.16858344 |
| 80 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.16858344 |
| 81 | * E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.16618407 |
| 82 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.16159154 |
| 83 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 1.15361419 |
| 84 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.14333788 |
| 85 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.13397009 |
| 86 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.12270007 |
| 87 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.11954270 |
| 88 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.11237615 |
| 89 | ZIC3_20872845_ChIP-ChIP_MESCs_Mouse | 1.10754615 |
| 90 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.10475559 |
| 91 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 1.06483586 |
| 92 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 1.04341347 |
| 93 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.98040298 |
| 94 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.97835518 |
| 95 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 0.96555263 |
| 96 | P300_19829295_ChIP-Seq_ESCs_Human | 0.96351673 |
| 97 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.95501196 |
| 98 | MYC_18940864_ChIP-ChIP_HL60_Human | 0.93119289 |
| 99 | * CHD1_26751641_Chip-Seq_LNCaP_Human | 0.93101758 |
| 100 | FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human | 0.92211231 |
| 101 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 0.92175828 |
| 102 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 0.92042955 |
| 103 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 0.90485697 |
| 104 | TCF3_18692474_ChIP-Seq_MESCs_Mouse | 0.89695027 |
| 105 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.89039067 |
| 106 | * HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 0.88742465 |
| 107 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 0.88005443 |
| 108 | * POU5F1_18347094_ChIP-ChIP_MESCs_Mouse | 0.86913162 |
| 109 | IGF1R_20145208_ChIP-Seq_DFB_Human | 0.86325785 |
| 110 | VDR_21846776_ChIP-Seq_THP-1_Human | 0.85076644 |
| 111 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 0.84395515 |
| 112 | * TRIM28_19339689_ChIP-ChIP_MESCs_Mouse | 0.83854393 |
| 113 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.83376354 |
| 114 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.83356436 |
| 115 | TBX3_20139965_ChIP-Seq_ESCs_Mouse | 0.82136632 |
| 116 | TBX3_20139965_ChIP-Seq_MESCs_Mouse | 0.81496724 |
| 117 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 0.80486716 |
| 118 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.80331071 |
| 119 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.79771844 |
| 120 | SOX9_26525672_Chip-Seq_HEART_Mouse | 0.79652783 |
| 121 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.78581933 |
| 122 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 0.78096466 |
| 123 | SOX2_18358816_ChIP-ChIP_MESCs_Mouse | 0.77673112 |
| 124 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 0.77601224 |
| 125 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.77523643 |
| 126 | RNF2_27304074_Chip-Seq_NSC_Mouse | 0.76789329 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 4.22268767 |
| 2 | MP0010094_abnormal_chromosome_stability | 4.11708629 |
| 3 | MP0004957_abnormal_blastocyst_morpholog | 3.91112344 |
| 4 | MP0003111_abnormal_nucleus_morphology | 3.88001641 |
| 5 | MP0003077_abnormal_cell_cycle | 3.53787428 |
| 6 | MP0008057_abnormal_DNA_replication | 3.51004905 |
| 7 | MP0003123_paternal_imprinting | 3.27921823 |
| 8 | MP0010352_gastrointestinal_tract_polyps | 2.82515353 |
| 9 | MP0008058_abnormal_DNA_repair | 2.51779116 |
| 10 | MP0008007_abnormal_cellular_replicative | 2.51232771 |
| 11 | MP0001730_embryonic_growth_arrest | 2.49988479 |
| 12 | MP0008932_abnormal_embryonic_tissue | 2.48344199 |
| 13 | MP0000350_abnormal_cell_proliferation | 2.34185194 |
| 14 | MP0010030_abnormal_orbit_morphology | 2.34049843 |
| 15 | MP0003121_genomic_imprinting | 2.21972597 |
| 16 | MP0000537_abnormal_urethra_morphology | 2.02517392 |
| 17 | MP0005076_abnormal_cell_differentiation | 2.02193187 |
| 18 | MP0001672_abnormal_embryogenesis/_devel | 1.98373911 |
| 19 | MP0005380_embryogenesis_phenotype | 1.98373911 |
| 20 | MP0010307_abnormal_tumor_latency | 1.98065810 |
| 21 | MP0009053_abnormal_anal_canal | 1.97946520 |
| 22 | MP0002084_abnormal_developmental_patter | 1.97882656 |
| 23 | MP0004197_abnormal_fetal_growth/weight/ | 1.96102442 |
| 24 | MP0001697_abnormal_embryo_size | 1.95778294 |
| 25 | MP0008877_abnormal_DNA_methylation | 1.95188452 |
| 26 | MP0003890_abnormal_embryonic-extraembry | 1.90530464 |
| 27 | MP0002085_abnormal_embryonic_tissue | 1.90301249 |
| 28 | MP0001188_hyperpigmentation | 1.88258729 |
| 29 | MP0003984_embryonic_growth_retardation | 1.81353961 |
| 30 | MP0002088_abnormal_embryonic_growth/wei | 1.78365509 |
| 31 | MP0003705_abnormal_hypodermis_morpholog | 1.76544120 |
| 32 | MP0002009_preneoplasia | 1.75456831 |
| 33 | MP0009697_abnormal_copulation | 1.73569555 |
| 34 | MP0003567_abnormal_fetal_cardiomyocyte | 1.69680060 |
| 35 | MP0002080_prenatal_lethality | 1.66598043 |
| 36 | MP0002086_abnormal_extraembryonic_tissu | 1.64755843 |
| 37 | MP0002396_abnormal_hematopoietic_system | 1.64634300 |
| 38 | MP0001293_anophthalmia | 1.63436422 |
| 39 | MP0009379_abnormal_foot_pigmentation | 1.63242968 |
| 40 | MP0003136_yellow_coat_color | 1.60117630 |
| 41 | MP0003119_abnormal_digestive_system | 1.51940508 |
| 42 | MP0002653_abnormal_ependyma_morphology | 1.50615118 |
| 43 | MP0000566_synostosis | 1.48676148 |
| 44 | MP0004808_abnormal_hematopoietic_stem | 1.41395482 |
| 45 | MP0002234_abnormal_pharynx_morphology | 1.39983420 |
| 46 | MP0003937_abnormal_limbs/digits/tail_de | 1.30160618 |
| 47 | MP0000778_abnormal_nervous_system | 1.29677555 |
| 48 | MP0003786_premature_aging | 1.27188636 |
| 49 | MP0009672_abnormal_birth_weight | 1.25907562 |
| 50 | MP0002697_abnormal_eye_size | 1.25353966 |
| 51 | MP0003941_abnormal_skin_development | 1.24474186 |
| 52 | MP0003718_maternal_effect | 1.23894630 |
| 53 | MP0003283_abnormal_digestive_organ | 1.23123976 |
| 54 | MP0000428_abnormal_craniofacial_morphol | 1.22197820 |
| 55 | MP0003122_maternal_imprinting | 1.20318159 |
| 56 | MP0001299_abnormal_eye_distance/ | 1.18979733 |
| 57 | MP0000313_abnormal_cell_death | 1.18834275 |
| 58 | MP0009703_decreased_birth_body | 1.16211705 |
| 59 | MP0000490_abnormal_crypts_of | 1.14575180 |
| 60 | MP0006072_abnormal_retinal_apoptosis | 1.11331406 |
| 61 | MP0004133_heterotaxia | 1.09573527 |
| 62 | MP0002111_abnormal_tail_morphology | 1.07237202 |
| 63 | MP0001286_abnormal_eye_development | 1.07001661 |
| 64 | MP0003315_abnormal_perineum_morphology | 1.06963020 |
| 65 | MP0003115_abnormal_respiratory_system | 1.06646412 |
| 66 | MP0005623_abnormal_meninges_morphology | 1.06475306 |
| 67 | MP0005248_abnormal_Harderian_gland | 1.06334997 |
| 68 | MP0004233_abnormal_muscle_weight | 1.03905963 |
| 69 | MP0002019_abnormal_tumor_incidence | 1.03324555 |
| 70 | MP0002092_abnormal_eye_morphology | 1.03168444 |
| 71 | MP0000733_abnormal_muscle_development | 1.00017881 |
| 72 | MP0002102_abnormal_ear_morphology | 0.99969012 |
| 73 | MP0003938_abnormal_ear_development | 0.99238873 |
| 74 | MP0002210_abnormal_sex_determination | 0.98134371 |
| 75 | MP0003861_abnormal_nervous_system | 0.97944849 |
| 76 | MP0006292_abnormal_olfactory_placode | 0.97764089 |
| 77 | MP0003942_abnormal_urinary_system | 0.96558485 |
| 78 | MP0001177_atelectasis | 0.94510414 |
| 79 | MP0003935_abnormal_craniofacial_develop | 0.93314013 |
| 80 | MP0005394_taste/olfaction_phenotype | 0.92669881 |
| 81 | MP0005499_abnormal_olfactory_system | 0.92669881 |
| 82 | MP0006054_spinal_hemorrhage | 0.92454006 |
| 83 | MP0001346_abnormal_lacrimal_gland | 0.92099589 |
| 84 | MP0001915_intracranial_hemorrhage | 0.91942572 |
| 85 | MP0003755_abnormal_palate_morphology | 0.89416306 |
| 86 | MP0009250_abnormal_appendicular_skeleto | 0.89348949 |
| 87 | MP0000432_abnormal_head_morphology | 0.89271192 |
| 88 | MP0003385_abnormal_body_wall | 0.87811053 |
| 89 | MP0005391_vision/eye_phenotype | 0.87663168 |
| 90 | MP0001145_abnormal_male_reproductive | 0.87160272 |
| 91 | MP0000631_abnormal_neuroendocrine_gland | 0.87059942 |
| 92 | MP0001849_ear_inflammation | 0.84200253 |
| 93 | MP0002932_abnormal_joint_morphology | 0.83304995 |
| 94 | MP0002877_abnormal_melanocyte_morpholog | 0.83241411 |
| 95 | MP0002925_abnormal_cardiovascular_devel | 0.83158645 |
| 96 | MP0008789_abnormal_olfactory_epithelium | 0.82719249 |
| 97 | MP0003787_abnormal_imprinting | 0.81950570 |
| 98 | MP0002938_white_spotting | 0.81681730 |
| 99 | MP0000049_abnormal_middle_ear | 0.81244283 |
| 100 | MP0003566_abnormal_cell_adhesion | 0.78845852 |
| 101 | MP0002177_abnormal_outer_ear | 0.78706266 |
| 102 | MP0002751_abnormal_autonomic_nervous | 0.76809417 |
| 103 | MP0002160_abnormal_reproductive_system | 0.76048878 |
| 104 | MP0000703_abnormal_thymus_morphology | 0.75963273 |
| 105 | MP0002114_abnormal_axial_skeleton | 0.75827516 |
| 106 | MP0002282_abnormal_trachea_morphology | 0.75134177 |
| 107 | MP0001529_abnormal_vocalization | 0.73369320 |
| 108 | MP0005384_cellular_phenotype | 0.72490432 |
| 109 | MP0005187_abnormal_penis_morphology | 0.72328909 |
| 110 | MP0002116_abnormal_craniofacial_bone | 0.72182381 |
| 111 | MP0000534_abnormal_ureter_morphology | 0.70459009 |
| 112 | MP0005023_abnormal_wound_healing | 0.70369893 |
| 113 | MP0000762_abnormal_tongue_morphology | 0.70215978 |
| 114 | MP0000653_abnormal_sex_gland | 0.70084360 |
| 115 | MP0005367_renal/urinary_system_phenotyp | 0.69969713 |
| 116 | MP0000516_abnormal_urinary_system | 0.69969713 |
| 117 | MP0003943_abnormal_hepatobiliary_system | 0.68432924 |
| 118 | MP0009278_abnormal_bone_marrow | 0.67585340 |
| 119 | MP0002081_perinatal_lethality | 0.67270880 |
| 120 | MP0005621_abnormal_cell_physiology | 0.67267621 |
| 121 | MP0000569_abnormal_digit_pigmentation | 0.65582635 |
| 122 | MP0010234_abnormal_vibrissa_follicle | 0.65408941 |
| 123 | MP0001929_abnormal_gametogenesis | 0.64423715 |
| 124 | MP0008770_decreased_survivor_rate | 0.64349889 |
| 125 | MP0001340_abnormal_eyelid_morphology | 0.63542315 |
| 126 | MP0002233_abnormal_nose_morphology | 0.62036310 |
| 127 | MP0000266_abnormal_heart_morphology | 0.61648320 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Birth length less than 3rd percentile (HP:0003561) | 3.69506995 |
| 2 | Colon cancer (HP:0003003) | 3.62911230 |
| 3 | Ependymoma (HP:0002888) | 3.53419756 |
| 4 | Medulloblastoma (HP:0002885) | 3.31439305 |
| 5 | Selective tooth agenesis (HP:0001592) | 3.23664273 |
| 6 | Volvulus (HP:0002580) | 3.08328191 |
| 7 | Increased nuchal translucency (HP:0010880) | 3.03874022 |
| 8 | Abnormal number of incisors (HP:0011064) | 3.00090895 |
| 9 | Abnormality of the labia minora (HP:0012880) | 2.96376298 |
| 10 | Patellar aplasia (HP:0006443) | 2.89778662 |
| 11 | Short 4th metacarpal (HP:0010044) | 2.80885967 |
| 12 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 2.80885967 |
| 13 | Proximal placement of thumb (HP:0009623) | 2.79974525 |
| 14 | Chromsome breakage (HP:0040012) | 2.78522209 |
| 15 | Deviation of the thumb (HP:0009603) | 2.77615866 |
| 16 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.74769211 |
| 17 | Degeneration of anterior horn cells (HP:0002398) | 2.72812096 |
| 18 | Abnormality of the anterior horn cell (HP:0006802) | 2.72812096 |
| 19 | Septo-optic dysplasia (HP:0100842) | 2.71803906 |
| 20 | Reticulocytopenia (HP:0001896) | 2.71247088 |
| 21 | Breast hypoplasia (HP:0003187) | 2.64240234 |
| 22 | Astrocytoma (HP:0009592) | 2.62898670 |
| 23 | Abnormality of the astrocytes (HP:0100707) | 2.62898670 |
| 24 | Rhabdomyosarcoma (HP:0002859) | 2.59679570 |
| 25 | Cortical dysplasia (HP:0002539) | 2.52340139 |
| 26 | Stenosis of the external auditory canal (HP:0000402) | 2.52170277 |
| 27 | Atresia of the external auditory canal (HP:0000413) | 2.49907068 |
| 28 | Abnormality of chromosome stability (HP:0003220) | 2.48235041 |
| 29 | Triphalangeal thumb (HP:0001199) | 2.48145036 |
| 30 | Renal duplication (HP:0000075) | 2.45458930 |
| 31 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.44905170 |
| 32 | Absent radius (HP:0003974) | 2.35540511 |
| 33 | Agnosia (HP:0010524) | 2.34583224 |
| 34 | Glioma (HP:0009733) | 2.32883597 |
| 35 | Meckel diverticulum (HP:0002245) | 2.32749137 |
| 36 | Pelvic girdle muscle weakness (HP:0003749) | 2.28797491 |
| 37 | Ectopic kidney (HP:0000086) | 2.26612712 |
| 38 | Basal cell carcinoma (HP:0002671) | 2.24177232 |
| 39 | Facial hemangioma (HP:0000329) | 2.23821546 |
| 40 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 2.22995486 |
| 41 | Aplasia involving forearm bones (HP:0009822) | 2.21425040 |
| 42 | Absent forearm bone (HP:0003953) | 2.21425040 |
| 43 | Missing ribs (HP:0000921) | 2.21011992 |
| 44 | Abnormality of the ileum (HP:0001549) | 2.20372410 |
| 45 | Vitreoretinal degeneration (HP:0000655) | 2.20261003 |
| 46 | Supernumerary spleens (HP:0009799) | 2.20194943 |
| 47 | Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376) | 2.18827717 |
| 48 | Abdominal situs inversus (HP:0003363) | 2.18359157 |
| 49 | Abnormality of abdominal situs (HP:0011620) | 2.18359157 |
| 50 | Neoplasm of the pancreas (HP:0002894) | 2.17514006 |
| 51 | Irregular epiphyses (HP:0010582) | 2.16374642 |
| 52 | Neoplasm of striated muscle (HP:0009728) | 2.16275058 |
| 53 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.14956258 |
| 54 | Impulsivity (HP:0100710) | 2.14540407 |
| 55 | Shoulder girdle muscle weakness (HP:0003547) | 2.14339371 |
| 56 | Neoplasm of the oral cavity (HP:0100649) | 2.13782124 |
| 57 | Small intestinal stenosis (HP:0012848) | 2.11831698 |
| 58 | Duodenal stenosis (HP:0100867) | 2.11831698 |
| 59 | Biliary tract neoplasm (HP:0100574) | 2.11289755 |
| 60 | Abnormal lung lobation (HP:0002101) | 2.10474286 |
| 61 | Short middle phalanx of the 5th finger (HP:0004220) | 2.10139533 |
| 62 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.06973079 |
| 63 | Absent thumb (HP:0009777) | 2.06893005 |
| 64 | Oral leukoplakia (HP:0002745) | 2.05521269 |
| 65 | Abnormality of the 4th metacarpal (HP:0010012) | 2.05113870 |
| 66 | Hypoplastic pelvis (HP:0008839) | 2.03373267 |
| 67 | Cystic hygroma (HP:0000476) | 2.01604555 |
| 68 | Rib fusion (HP:0000902) | 2.00867744 |
| 69 | Intestinal atresia (HP:0011100) | 2.00646006 |
| 70 | High anterior hairline (HP:0009890) | 2.00160799 |
| 71 | Bifid tongue (HP:0010297) | 2.00156402 |
| 72 | Absent septum pellucidum (HP:0001331) | 1.99761323 |
| 73 | Abnormality of the preputium (HP:0100587) | 1.99087145 |
| 74 | Hepatoblastoma (HP:0002884) | 1.97945802 |
| 75 | Myelodysplasia (HP:0002863) | 1.97887059 |
| 76 | Abnormality of the septum pellucidum (HP:0007375) | 1.97355644 |
| 77 | Carpal bone hypoplasia (HP:0001498) | 1.94432716 |
| 78 | Dyschromatopsia (HP:0007641) | 1.94315918 |
| 79 | High pitched voice (HP:0001620) | 1.94146589 |
| 80 | Malignant gastrointestinal tract tumors (HP:0006749) | 1.92276517 |
| 81 | Gastrointestinal carcinoma (HP:0002672) | 1.92276517 |
| 82 | Long eyelashes (HP:0000527) | 1.91452488 |
| 83 | Tracheoesophageal fistula (HP:0002575) | 1.91407067 |
| 84 | Nephroblastoma (Wilms tumor) (HP:0002667) | 1.91193102 |
| 85 | Macrocytic anemia (HP:0001972) | 1.87543766 |
| 86 | Cafe-au-lait spot (HP:0000957) | 1.87534260 |
| 87 | Abnormality of the phalanges of the 5th finger (HP:0004213) | 1.86646940 |
| 88 | Abnormality of the duodenum (HP:0002246) | 1.86287261 |
| 89 | Abnormality of the musculature of the pelvis (HP:0001469) | 1.84728285 |
| 90 | Abnormality of the hip-girdle musculature (HP:0001445) | 1.84728285 |
| 91 | Embryonal renal neoplasm (HP:0011794) | 1.84529957 |
| 92 | Broad thumb (HP:0011304) | 1.84514632 |
| 93 | Abnormality of cochlea (HP:0000375) | 1.84243993 |
| 94 | Overlapping toe (HP:0001845) | 1.84008128 |
| 95 | Abnormality of the phalanges of the 2nd finger (HP:0009541) | 1.82930477 |
| 96 | Horseshoe kidney (HP:0000085) | 1.82392995 |
| 97 | Aplasia/hypoplasia of the humerus (HP:0006507) | 1.82092483 |
| 98 | Bilateral microphthalmos (HP:0007633) | 1.80622744 |
| 99 | Prominent nose (HP:0000448) | 1.80525287 |
| 100 | Skull defect (HP:0001362) | 1.79397065 |
| 101 | Abnormal number of erythroid precursors (HP:0012131) | 1.78970893 |
| 102 | Abnormality of the carotid arteries (HP:0005344) | 1.78846547 |
| 103 | Small hand (HP:0200055) | 1.78841221 |
| 104 | 11 pairs of ribs (HP:0000878) | 1.78454537 |
| 105 | Abnormality of the calcaneus (HP:0008364) | 1.78387301 |
| 106 | Deep philtrum (HP:0002002) | 1.78086484 |
| 107 | Hyperacusis (HP:0010780) | 1.77640381 |
| 108 | Oligodactyly (HP:0012165) | 1.77532105 |
| 109 | Short middle phalanx of finger (HP:0005819) | 1.77057201 |
| 110 | Duplication of thumb phalanx (HP:0009942) | 1.76474684 |
| 111 | Aqueductal stenosis (HP:0002410) | 1.75356012 |
| 112 | Gonadotropin excess (HP:0000837) | 1.74594516 |
| 113 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 1.74555739 |
| 114 | Neoplasm of the colon (HP:0100273) | 1.73867433 |
| 115 | Skin tags (HP:0010609) | 1.73866849 |
| 116 | Multiple enchondromatosis (HP:0005701) | 1.73861763 |
| 117 | Increased density of long bones (HP:0006392) | 1.73307208 |
| 118 | Esophageal atresia (HP:0002032) | 1.73031122 |
| 119 | Intestinal polyp (HP:0005266) | 1.72945464 |
| 120 | Bowel diverticulosis (HP:0005222) | 1.71599572 |
| 121 | Slender long bone (HP:0003100) | 1.71194111 |
| 122 | Ovarian neoplasm (HP:0100615) | 1.70650928 |
| 123 | Sloping forehead (HP:0000340) | 1.70387508 |
| 124 | Preauricular skin tag (HP:0000384) | 1.69654566 |
| 125 | Premature graying of hair (HP:0002216) | 1.69177606 |
| 126 | Embryonal neoplasm (HP:0002898) | 1.69012185 |
| 127 | Short thumb (HP:0009778) | 1.68747795 |
| 128 | Anophthalmia (HP:0000528) | 1.68647267 |
| 129 | Broad phalanges of the hand (HP:0009768) | 1.68558993 |
| 130 | Intestinal polyposis (HP:0200008) | 1.68489973 |
| 131 | Acute myeloid leukemia (HP:0004808) | 1.68177388 |
| 132 | Choanal atresia (HP:0000453) | 1.65627700 |
| 133 | Transitional cell carcinoma of the bladder (HP:0006740) | 1.65329124 |
| 134 | Myelomeningocele (HP:0002475) | 1.64477372 |
| 135 | Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161) | 1.64006864 |
| 136 | Facial cleft (HP:0002006) | 1.61100579 |
| 137 | Acute lymphatic leukemia (HP:0006721) | 1.60771271 |
| 138 | Obsessive-compulsive behavior (HP:0000722) | 1.60207561 |
| 139 | Spastic diplegia (HP:0001264) | 1.60031285 |
| 140 | Omphalocele (HP:0001539) | 1.59680557 |
| 141 | Maternal diabetes (HP:0009800) | 1.58989707 |
| 142 | Uterine neoplasm (HP:0010784) | 1.58004089 |
| 143 | Uterine leiomyosarcoma (HP:0002891) | 1.57744173 |
| 144 | Leiomyosarcoma (HP:0100243) | 1.57744173 |
| 145 | Gastrointestinal atresia (HP:0002589) | 1.56952819 |
| 146 | Abnormality of chromosome segregation (HP:0002916) | 1.56915583 |
| 147 | Pancreatic islet-cell hyperplasia (HP:0004510) | 1.56796677 |
| 148 | Aplasia/Hypoplasia of the breasts (HP:0010311) | 1.55631410 |
| 149 | Abnormality of the ischium (HP:0003174) | 1.55594763 |
| 150 | Long clavicles (HP:0000890) | 1.54435856 |
| 151 | Neoplasm of the adrenal cortex (HP:0100641) | 1.53793143 |
| 152 | Breast aplasia (HP:0100783) | 1.52513250 |
| 153 | Morphological abnormality of the inner ear (HP:0011390) | 1.50798437 |
| 154 | Papillary thyroid carcinoma (HP:0002895) | 1.50658663 |
| 155 | Absent eyebrow (HP:0002223) | 1.50620526 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | CDC7 | 5.10709102 |
| 2 | WEE1 | 3.83838710 |
| 3 | BUB1 | 3.29406012 |
| 4 | NEK1 | 3.22346432 |
| 5 | NEK2 | 3.05152695 |
| 6 | CDK12 | 2.88800169 |
| 7 | MKNK1 | 2.76442458 |
| 8 | TNIK | 2.65173067 |
| 9 | TAF1 | 2.61840022 |
| 10 | SRPK1 | 2.55008458 |
| 11 | TSSK6 | 2.54415027 |
| 12 | TTK | 2.33926426 |
| 13 | EIF2AK1 | 2.22715571 |
| 14 | PASK | 2.14060226 |
| 15 | EEF2K | 1.99998072 |
| 16 | PLK3 | 1.98121827 |
| 17 | MKNK2 | 1.90648042 |
| 18 | PLK1 | 1.90179953 |
| 19 | SCYL2 | 1.78023147 |
| 20 | PLK4 | 1.73354818 |
| 21 | BRSK2 | 1.72659758 |
| 22 | ATR | 1.71833929 |
| 23 | PNCK | 1.68010520 |
| 24 | RPS6KB2 | 1.67958544 |
| 25 | BRD4 | 1.66074873 |
| 26 | CDK7 | 1.65928700 |
| 27 | VRK2 | 1.64976936 |
| 28 | ACVR1B | 1.64202741 |
| 29 | AURKB | 1.63037902 |
| 30 | TRIM28 | 1.61622371 |
| 31 | MAP3K10 | 1.55364158 |
| 32 | PKN2 | 1.54753753 |
| 33 | RPS6KA4 | 1.53345304 |
| 34 | CDK19 | 1.53308544 |
| 35 | CHEK1 | 1.46958829 |
| 36 | ALK | 1.45338055 |
| 37 | CDK4 | 1.43325890 |
| 38 | PBK | 1.42384301 |
| 39 | CHEK2 | 1.42138992 |
| 40 | NUAK1 | 1.39088226 |
| 41 | MAP3K8 | 1.38081804 |
| 42 | DYRK3 | 1.35977543 |
| 43 | TGFBR1 | 1.35288271 |
| 44 | BCR | 1.26007387 |
| 45 | PAK4 | 1.26006272 |
| 46 | CDK6 | 1.24431638 |
| 47 | LATS2 | 1.20317528 |
| 48 | BRSK1 | 1.16497876 |
| 49 | EIF2AK3 | 1.16339819 |
| 50 | STK10 | 1.15853837 |
| 51 | LATS1 | 1.11992195 |
| 52 | ATM | 1.08766367 |
| 53 | AURKA | 1.06521877 |
| 54 | CDK2 | 1.05778356 |
| 55 | STK24 | 1.05651255 |
| 56 | TESK2 | 0.96823958 |
| 57 | CDK3 | 0.95458949 |
| 58 | STK3 | 0.92071799 |
| 59 | FGFR1 | 0.89052376 |
| 60 | FGFR2 | 0.88129678 |
| 61 | WNK3 | 0.88094548 |
| 62 | LRRK2 | 0.84472269 |
| 63 | EPHA2 | 0.83235006 |
| 64 | CDK1 | 0.83080642 |
| 65 | ERBB3 | 0.82690620 |
| 66 | MELK | 0.81116068 |
| 67 | VRK1 | 0.79124713 |
| 68 | MTOR | 0.77954966 |
| 69 | YES1 | 0.75688068 |
| 70 | NME2 | 0.75401180 |
| 71 | CSNK2A2 | 0.72950270 |
| 72 | PAK2 | 0.72453590 |
| 73 | STK4 | 0.71370187 |
| 74 | BMPR1B | 0.71124573 |
| 75 | CAMK1G | 0.70852556 |
| 76 | MAP3K4 | 0.68131678 |
| 77 | CSNK1E | 0.67667601 |
| 78 | CCNB1 | 0.65241373 |
| 79 | SMG1 | 0.65082767 |
| 80 | CDK8 | 0.64635137 |
| 81 | KSR1 | 0.63141206 |
| 82 | NLK | 0.60270526 |
| 83 | STK16 | 0.59372883 |
| 84 | PDGFRA | 0.58831758 |
| 85 | DYRK2 | 0.58537728 |
| 86 | CSNK2A1 | 0.56261312 |
| 87 | EPHB2 | 0.55823326 |
| 88 | PRKDC | 0.54993519 |
| 89 | PAK1 | 0.53479576 |
| 90 | FLT3 | 0.53164809 |
| 91 | TRIB3 | 0.52487368 |
| 92 | PIM1 | 0.51113433 |
| 93 | TLK1 | 0.50199751 |
| 94 | PRKCI | 0.48552861 |
| 95 | CSNK1G1 | 0.47004090 |
| 96 | CSNK1D | 0.45858426 |
| 97 | STK38L | 0.45340181 |
| 98 | AKT2 | 0.45186945 |
| 99 | PLK2 | 0.44680216 |
| 100 | MST4 | 0.43398013 |
| 101 | MAPK14 | 0.41700200 |
| 102 | UHMK1 | 0.41655570 |
| 103 | ILK | 0.39190758 |
| 104 | EPHA4 | 0.38999333 |
| 105 | ERBB4 | 0.36635089 |
| 106 | CASK | 0.34665443 |
| 107 | TYRO3 | 0.34340865 |
| 108 | MUSK | 0.33374537 |
| 109 | TESK1 | 0.33215041 |
| 110 | AKT1 | 0.32103184 |
| 111 | CSNK1G2 | 0.31884733 |
| 112 | CDK14 | 0.31374828 |
| 113 | DMPK | 0.31213067 |
| 114 | CAMK1D | 0.29975682 |
| 115 | CDK11A | 0.29936481 |
| 116 | GSK3B | 0.29841708 |
| 117 | TTN | 0.29828563 |
| 118 | CDK18 | 0.28444332 |
| 119 | MAP3K9 | 0.28403020 |
| 120 | BRAF | 0.27717225 |
| 121 | CDK15 | 0.27581945 |
| 122 | RPS6KB1 | 0.26386836 |
| 123 | CLK1 | 0.25667900 |
| 124 | NEK9 | 0.24373652 |
| 125 | BMX | 0.24229280 |
| 126 | MAPK1 | 0.22467583 |
| 127 | EIF2AK2 | 0.20903471 |
| 128 | DDR2 | 0.19555630 |
| 129 | TAOK2 | 0.19382381 |
| 130 | CDK9 | 0.18716384 |
| 131 | RPS6KA1 | 0.18232221 |
| 132 | MAPK9 | 0.18102860 |
| 133 | ZAK | 0.16423778 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA replication_Homo sapiens_hsa03030 | 4.58648371 |
| 2 | Mismatch repair_Homo sapiens_hsa03430 | 4.03311409 |
| 3 | Spliceosome_Homo sapiens_hsa03040 | 3.61395330 |
| 4 | RNA transport_Homo sapiens_hsa03013 | 3.53310762 |
| 5 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.46088561 |
| 6 | Cell cycle_Homo sapiens_hsa04110 | 3.11808404 |
| 7 | Base excision repair_Homo sapiens_hsa03410 | 2.78010876 |
| 8 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.65613902 |
| 9 | Homologous recombination_Homo sapiens_hsa03440 | 2.57889561 |
| 10 | Ribosome_Homo sapiens_hsa03010 | 2.52421468 |
| 11 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.52382199 |
| 12 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.47546462 |
| 13 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 2.39423329 |
| 14 | RNA polymerase_Homo sapiens_hsa03020 | 2.30259673 |
| 15 | Proteasome_Homo sapiens_hsa03050 | 2.13306352 |
| 16 | Protein export_Homo sapiens_hsa03060 | 2.04597439 |
| 17 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.02174989 |
| 18 | RNA degradation_Homo sapiens_hsa03018 | 1.97794684 |
| 19 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.94465982 |
| 20 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.76458838 |
| 21 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.64863932 |
| 22 | Basal transcription factors_Homo sapiens_hsa03022 | 1.59769785 |
| 23 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.52558112 |
| 24 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 1.43557769 |
| 25 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 1.38812907 |
| 26 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.35883328 |
| 27 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 1.25982857 |
| 28 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.23491884 |
| 29 | Thyroid cancer_Homo sapiens_hsa05216 | 1.15944012 |
| 30 | Hippo signaling pathway_Homo sapiens_hsa04390 | 1.14535932 |
| 31 | Basal cell carcinoma_Homo sapiens_hsa05217 | 1.12490392 |
| 32 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.11575545 |
| 33 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.10365558 |
| 34 | HTLV-I infection_Homo sapiens_hsa05166 | 1.06341674 |
| 35 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.05831016 |
| 36 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.03867504 |
| 37 | Colorectal cancer_Homo sapiens_hsa05210 | 0.99544142 |
| 38 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.97164097 |
| 39 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.96007303 |
| 40 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.95950954 |
| 41 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.93044585 |
| 42 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.91772489 |
| 43 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.90770201 |
| 44 | Adherens junction_Homo sapiens_hsa04520 | 0.90471506 |
| 45 | Purine metabolism_Homo sapiens_hsa00230 | 0.90231063 |
| 46 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.86039422 |
| 47 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.85765820 |
| 48 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.85237855 |
| 49 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.84538558 |
| 50 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.82695088 |
| 51 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.79916562 |
| 52 | Bladder cancer_Homo sapiens_hsa05219 | 0.73623366 |
| 53 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.73212063 |
| 54 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.69620918 |
| 55 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.68471162 |
| 56 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.67734032 |
| 57 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.66011175 |
| 58 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.65934824 |
| 59 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.65714325 |
| 60 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.64088187 |
| 61 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.61428294 |
| 62 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.61196733 |
| 63 | Pathways in cancer_Homo sapiens_hsa05200 | 0.61094716 |
| 64 | Endometrial cancer_Homo sapiens_hsa05213 | 0.61071212 |
| 65 | Prostate cancer_Homo sapiens_hsa05215 | 0.59608915 |
| 66 | Carbon metabolism_Homo sapiens_hsa01200 | 0.58765356 |
| 67 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.57516248 |
| 68 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.57048729 |
| 69 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.56736240 |
| 70 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.56379339 |
| 71 | Viral myocarditis_Homo sapiens_hsa05416 | 0.56334786 |
| 72 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.54971400 |
| 73 | Alcoholism_Homo sapiens_hsa05034 | 0.53405507 |
| 74 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.53029781 |
| 75 | Hepatitis B_Homo sapiens_hsa05161 | 0.52985667 |
| 76 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.51041726 |
| 77 | Melanoma_Homo sapiens_hsa05218 | 0.50624411 |
| 78 | Tight junction_Homo sapiens_hsa04530 | 0.50025392 |
| 79 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.48992223 |
| 80 | Shigellosis_Homo sapiens_hsa05131 | 0.48615437 |
| 81 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.45013366 |
| 82 | Glioma_Homo sapiens_hsa05214 | 0.43994674 |
| 83 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.43207202 |
| 84 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.42254036 |
| 85 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.42225964 |
| 86 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.41401608 |
| 87 | Legionellosis_Homo sapiens_hsa05134 | 0.39698126 |
| 88 | Apoptosis_Homo sapiens_hsa04210 | 0.38188951 |
| 89 | Axon guidance_Homo sapiens_hsa04360 | 0.38164219 |
| 90 | Huntingtons disease_Homo sapiens_hsa05016 | 0.37442559 |
| 91 | Focal adhesion_Homo sapiens_hsa04510 | 0.35131810 |
| 92 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 0.34976311 |
| 93 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.34658249 |
| 94 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.33406108 |
| 95 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.32488719 |
| 96 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.31098130 |
| 97 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.29076413 |
| 98 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.28674049 |
| 99 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.27736461 |
| 100 | Lysine degradation_Homo sapiens_hsa00310 | 0.27073984 |
| 101 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.26250558 |
| 102 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.25741947 |
| 103 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.24832522 |
| 104 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.24104299 |
| 105 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.23725292 |
| 106 | Melanogenesis_Homo sapiens_hsa04916 | 0.23118185 |
| 107 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.22155127 |
| 108 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.21786105 |
| 109 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.21004614 |
| 110 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.20624604 |
| 111 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.19951458 |
| 112 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.19813314 |
| 113 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.19432904 |
| 114 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.19393910 |
| 115 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.19130431 |
| 116 | Long-term depression_Homo sapiens_hsa04730 | 0.18495275 |
| 117 | Olfactory transduction_Homo sapiens_hsa04740 | 0.17621738 |
| 118 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.16887112 |
| 119 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.16690320 |
| 120 | Measles_Homo sapiens_hsa05162 | 0.15440649 |
| 121 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.14985797 |
| 122 | Gap junction_Homo sapiens_hsa04540 | 0.14031265 |
| 123 | Long-term potentiation_Homo sapiens_hsa04720 | 0.13998264 |
| 124 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.13520181 |
| 125 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.13456279 |
| 126 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.13294650 |
| 127 | Influenza A_Homo sapiens_hsa05164 | 0.12424336 |
| 128 | Taste transduction_Homo sapiens_hsa04742 | 0.12204538 |
| 129 | Phototransduction_Homo sapiens_hsa04744 | 0.11965947 |
| 130 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.11667388 |
| 131 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.11030266 |
| 132 | Metabolic pathways_Homo sapiens_hsa01100 | 0.10557017 |

