NAP1L1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosome assembly (GO:0042255)5.26056035
2CENP-A containing nucleosome assembly (GO:0034080)4.78920066
3chromatin remodeling at centromere (GO:0031055)4.72957071
4protein neddylation (GO:0045116)4.65390001
5histone exchange (GO:0043486)4.54759210
6proteasome assembly (GO:0043248)4.51469325
7exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 4.49903591
8nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)4.34791078
9regulation of development, heterochronic (GO:0040034)4.31034822
10DNA deamination (GO:0045006)4.01947842
11DNA replication-dependent nucleosome organization (GO:0034723)3.93638099
12DNA replication-dependent nucleosome assembly (GO:0006335)3.93638099
13DNA replication-independent nucleosome assembly (GO:0006336)3.91349794
14DNA replication-independent nucleosome organization (GO:0034724)3.91349794
15regulation of mitotic spindle checkpoint (GO:1903504)3.88756523
16regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.88756523
17regulation of DNA endoreduplication (GO:0032875)3.84589895
18establishment of protein localization to mitochondrial membrane (GO:0090151)3.82243643
19rRNA modification (GO:0000154)3.79858141
20establishment of integrated proviral latency (GO:0075713)3.77549010
21histone mRNA metabolic process (GO:0008334)3.67990373
22organelle disassembly (GO:1903008)3.64955210
23maturation of 5.8S rRNA (GO:0000460)3.63641735
24DNA double-strand break processing (GO:0000729)3.57310865
25rRNA methylation (GO:0031167)3.52281367
26somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.49374657
27somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.49374657
28isotype switching (GO:0045190)3.49374657
29regulation of centriole replication (GO:0046599)3.48213048
30formation of translation preinitiation complex (GO:0001731)3.41335533
31viral mRNA export from host cell nucleus (GO:0046784)3.38417298
32ribosomal large subunit biogenesis (GO:0042273)3.28184746
33regulation of transcription from RNA polymerase I promoter (GO:0006356)3.27818645
34chaperone-mediated protein transport (GO:0072321)3.26179482
35mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.24947530
36ATP synthesis coupled proton transport (GO:0015986)3.18983606
37energy coupled proton transport, down electrochemical gradient (GO:0015985)3.18983606
38regulation of posttranscriptional gene silencing (GO:0060147)3.18571009
39regulation of gene silencing by miRNA (GO:0060964)3.18571009
40regulation of gene silencing by RNA (GO:0060966)3.18571009
41dorsal/ventral axis specification (GO:0009950)3.16528689
42negative regulation of DNA-dependent DNA replication (GO:2000104)3.15483547
43regulation of timing of cell differentiation (GO:0048505)3.13330833
44RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.12518586
45signal peptide processing (GO:0006465)3.12239909
46cytoplasmic mRNA processing body assembly (GO:0033962)3.12229479
47termination of RNA polymerase III transcription (GO:0006386)3.11304354
48transcription elongation from RNA polymerase III promoter (GO:0006385)3.11304354
49DNA damage response, detection of DNA damage (GO:0042769)3.08006573
50alternative mRNA splicing, via spliceosome (GO:0000380)3.06999244
51DNA replication checkpoint (GO:0000076)3.01789315
52postreplication repair (GO:0006301)3.01254820
53IMP biosynthetic process (GO:0006188)3.00629769
54somatic recombination of immunoglobulin gene segments (GO:0016447)2.98188297
55spliceosomal snRNP assembly (GO:0000387)2.97558123
56water-soluble vitamin biosynthetic process (GO:0042364)2.95871790
57ATP-dependent chromatin remodeling (GO:0043044)2.95530590
58regulation of meiosis I (GO:0060631)2.93130600
59mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.87777177
60spliceosomal complex assembly (GO:0000245)2.86869713
61DNA catabolic process, exonucleolytic (GO:0000738)2.86325420
62nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:0000288)2.83302140
63IMP metabolic process (GO:0046040)2.82366612
64establishment of viral latency (GO:0019043)2.80493030
65centriole replication (GO:0007099)2.79652772
66DNA ligation (GO:0006266)2.77011757
67negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.75946194
68regulation of helicase activity (GO:0051095)2.75716699
69pituitary gland development (GO:0021983)2.75196516
70lateral sprouting from an epithelium (GO:0060601)2.74436387
71termination of RNA polymerase II transcription (GO:0006369)2.72733801
72somatic diversification of immunoglobulins (GO:0016445)2.72723439
73somatic diversification of immune receptors via somatic mutation (GO:0002566)2.70763801
74somatic hypermutation of immunoglobulin genes (GO:0016446)2.70763801
75mismatch repair (GO:0006298)2.68868018
76negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.66822850
77transcription from mitochondrial promoter (GO:0006390)2.66663231
78replication fork processing (GO:0031297)2.63583122
79RNA splicing, via transesterification reactions (GO:0000375)2.63552066
80cullin deneddylation (GO:0010388)2.62350283
81DNA-templated transcription, termination (GO:0006353)2.62109980
82somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.60857952
83somatic cell DNA recombination (GO:0016444)2.60857952
84regulation of nuclear cell cycle DNA replication (GO:0033262)2.60068936
85negative regulation of DNA recombination (GO:0045910)2.59878834
86regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.58267972
87ribonucleoprotein complex disassembly (GO:0032988)2.58205676
88rRNA processing (GO:0006364)2.55406481
89mRNA splicing, via spliceosome (GO:0000398)2.54050419
90RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.54050419
91neuron fate determination (GO:0048664)2.53952017
92negative regulation of transcription regulatory region DNA binding (GO:2000678)2.53838417
93mitotic metaphase plate congression (GO:0007080)2.51721762
94mRNA splice site selection (GO:0006376)2.51476494
95rRNA metabolic process (GO:0016072)2.49190076
96purine nucleobase biosynthetic process (GO:0009113)2.47756680
97protein deneddylation (GO:0000338)2.47600345
98ribonucleoprotein complex assembly (GO:0022618)2.47242254
99kidney morphogenesis (GO:0060993)2.46379734
100somatic diversification of immune receptors (GO:0002200)2.45577527

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.57101017
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.31995885
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.11596489
4EWS_26573619_Chip-Seq_HEK293_Human2.84620286
5MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.84320409
6TAF15_26573619_Chip-Seq_HEK293_Human2.77043950
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.77028673
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.61980621
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.61131639
10E2F7_22180533_ChIP-Seq_HELA_Human2.60922640
11ELK1_19687146_ChIP-ChIP_HELA_Human2.55905583
12VDR_22108803_ChIP-Seq_LS180_Human2.51991373
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.33031678
14POU5F1_16153702_ChIP-ChIP_HESCs_Human2.26304839
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.26153198
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.25171762
17IGF1R_20145208_ChIP-Seq_DFB_Human2.23055788
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.16700535
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.15996436
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.13035290
21FUS_26573619_Chip-Seq_HEK293_Human2.09094766
22VDR_23849224_ChIP-Seq_CD4+_Human2.08903879
23P300_19829295_ChIP-Seq_ESCs_Human2.07229340
24MYC_18940864_ChIP-ChIP_HL60_Human1.99534811
25PADI4_21655091_ChIP-ChIP_MCF-7_Human1.95902651
26SALL1_21062744_ChIP-ChIP_HESCs_Human1.94591664
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.94304630
28ZNF274_21170338_ChIP-Seq_K562_Hela1.90018336
29PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81738918
30KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.79594093
31JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.78718460
32CREB1_15753290_ChIP-ChIP_HEK293T_Human1.77293702
33ETS1_20019798_ChIP-Seq_JURKAT_Human1.69872806
34FOXP3_21729870_ChIP-Seq_TREG_Human1.68251348
35SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.67271875
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.66650732
37MYC_19030024_ChIP-ChIP_MESCs_Mouse1.66442870
38NANOG_16153702_ChIP-ChIP_HESCs_Human1.58680750
39FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.56167252
40GBX2_23144817_ChIP-Seq_PC3_Human1.53629018
41SOX2_16153702_ChIP-ChIP_HESCs_Human1.53429084
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.53388371
43TTF2_22483619_ChIP-Seq_HELA_Human1.49350848
44NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.49249785
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.44798944
46MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.42090073
47GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.40135759
48PCGF2_27294783_Chip-Seq_NPCs_Mouse1.37214786
49NOTCH1_21737748_ChIP-Seq_TLL_Human1.37207580
50CTBP2_25329375_ChIP-Seq_LNCAP_Human1.37026806
51ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.34734786
52CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.31634284
53POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.31397348
54YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29437155
55MYC_19079543_ChIP-ChIP_MESCs_Mouse1.26944593
56CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.25068531
57HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.23565450
58UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22202729
59SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21781565
60TP63_19390658_ChIP-ChIP_HaCaT_Human1.21723141
61NFE2_27457419_Chip-Seq_LIVER_Mouse1.17624518
62CBP_20019798_ChIP-Seq_JUKART_Human1.17606609
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17606609
64EZH2_27294783_Chip-Seq_NPCs_Mouse1.15617441
65HOXB4_20404135_ChIP-ChIP_EML_Mouse1.15483896
66TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14523787
67FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.12528865
68KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.12060964
69MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12035122
70MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.11625583
71ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.11499452
72NELFA_20434984_ChIP-Seq_ESCs_Mouse1.11150002
73ER_23166858_ChIP-Seq_MCF-7_Human1.10287171
74MYC_18358816_ChIP-ChIP_MESCs_Mouse1.08990694
75SOX2_19829295_ChIP-Seq_ESCs_Human1.08774915
76NANOG_19829295_ChIP-Seq_ESCs_Human1.08774915
77RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08635208
78RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.07543691
79EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06589489
80SMAD3_21741376_ChIP-Seq_EPCs_Human1.06010828
81IRF1_19129219_ChIP-ChIP_H3396_Human1.05786863
82SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05539758
83E2F1_21310950_ChIP-Seq_MCF-7_Human1.05514564
84CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.04609998
85DCP1A_22483619_ChIP-Seq_HELA_Human1.03884321
86E2F1_18555785_ChIP-Seq_MESCs_Mouse1.03292783
87AUTS2_25519132_ChIP-Seq_293T-REX_Human1.03137661
88OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02539502
89TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.99498916
90TP53_22573176_ChIP-Seq_HFKS_Human0.97990853
91AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97439592
92E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.96742949
93EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.96733261
94BMI1_23680149_ChIP-Seq_NPCS_Mouse0.96590901
95KLF5_20875108_ChIP-Seq_MESCs_Mouse0.96456424
96MYCN_18555785_ChIP-Seq_MESCs_Mouse0.96027910
97TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95851621
98SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.95507704
99RNF2_27304074_Chip-Seq_NSC_Mouse0.94399477
100TBX3_20139965_ChIP-Seq_ESCs_Mouse0.93749089

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.84482154
2MP0008877_abnormal_DNA_methylation3.05483824
3MP0010094_abnormal_chromosome_stability2.93192453
4MP0004957_abnormal_blastocyst_morpholog2.69476023
5MP0008058_abnormal_DNA_repair2.47035828
6MP0006072_abnormal_retinal_apoptosis2.41709271
7MP0002102_abnormal_ear_morphology2.40573941
8MP0008057_abnormal_DNA_replication2.32056336
9MP0005084_abnormal_gallbladder_morpholo2.23869482
10MP0002938_white_spotting2.17507850
11MP0008789_abnormal_olfactory_epithelium2.08217397
12MP0001293_anophthalmia2.07182436
13MP0002751_abnormal_autonomic_nervous2.06649919
14MP0003567_abnormal_fetal_cardiomyocyte1.99603452
15MP0003693_abnormal_embryo_hatching1.98189440
16MP0003121_genomic_imprinting1.86334719
17MP0001188_hyperpigmentation1.76032331
18MP0003890_abnormal_embryonic-extraembry1.75560139
19MP0003111_abnormal_nucleus_morphology1.75299793
20MP0003941_abnormal_skin_development1.72533415
21MP0005394_taste/olfaction_phenotype1.69115411
22MP0005499_abnormal_olfactory_system1.69115411
23MP0002736_abnormal_nociception_after1.68931457
24MP0003077_abnormal_cell_cycle1.61114011
25MP0001286_abnormal_eye_development1.59960524
26MP0009053_abnormal_anal_canal1.54019720
27MP0003119_abnormal_digestive_system1.53475897
28MP0003937_abnormal_limbs/digits/tail_de1.51116509
29MP0002638_abnormal_pupillary_reflex1.47175083
30MP0008872_abnormal_physiological_respon1.42067028
31MP0003787_abnormal_imprinting1.41609115
32MP0004885_abnormal_endolymph1.39764632
33MP0003283_abnormal_digestive_organ1.39741769
34MP0003136_yellow_coat_color1.36761555
35MP0008995_early_reproductive_senescence1.33605950
36MP0005257_abnormal_intraocular_pressure1.31997364
37MP0008932_abnormal_embryonic_tissue1.31581663
38MP0000778_abnormal_nervous_system1.30349450
39MP0003122_maternal_imprinting1.28681709
40MP0005645_abnormal_hypothalamus_physiol1.26743692
41MP0002837_dystrophic_cardiac_calcinosis1.23959838
42MP0002234_abnormal_pharynx_morphology1.23392793
43MP0004142_abnormal_muscle_tone1.20387133
44MP0000631_abnormal_neuroendocrine_gland1.20259970
45MP0002090_abnormal_vision1.18913798
46MP0001968_abnormal_touch/_nociception1.17400775
47MP0009697_abnormal_copulation1.17199647
48MP0000049_abnormal_middle_ear1.13396996
49MP0002160_abnormal_reproductive_system1.11601758
50MP0002233_abnormal_nose_morphology1.11523526
51MP0003880_abnormal_central_pattern1.09967723
52MP0002735_abnormal_chemical_nociception1.09380920
53MP0004133_heterotaxia1.06207835
54MP0004145_abnormal_muscle_electrophysio1.05917858
55MP0002084_abnormal_developmental_patter1.03997541
56MP0000537_abnormal_urethra_morphology1.03984136
57MP0005253_abnormal_eye_physiology1.03972514
58MP0002697_abnormal_eye_size1.03697437
59MP0003786_premature_aging1.03566804
60MP0003718_maternal_effect1.03245682
61MP0006035_abnormal_mitochondrial_morpho1.02832346
62MP0000428_abnormal_craniofacial_morphol1.01764873
63MP0004197_abnormal_fetal_growth/weight/0.98908148
64MP0002085_abnormal_embryonic_tissue0.98902999
65MP0003195_calcinosis0.98554426
66MP0001177_atelectasis0.98450894
67MP0001529_abnormal_vocalization0.97992028
68MP0002163_abnormal_gland_morphology0.97412975
69MP0003186_abnormal_redox_activity0.96032553
70MP0002111_abnormal_tail_morphology0.95647740
71MP0006036_abnormal_mitochondrial_physio0.95457172
72MP0002254_reproductive_system_inflammat0.94793268
73MP0001542_abnormal_bone_strength0.93159529
74MP0000516_abnormal_urinary_system0.93156261
75MP0005367_renal/urinary_system_phenotyp0.93156261
76MP0004147_increased_porphyrin_level0.89676575
77MP0008007_abnormal_cellular_replicative0.87569241
78MP0005195_abnormal_posterior_eye0.86752597
79MP0001697_abnormal_embryo_size0.86594740
80MP0009703_decreased_birth_body0.85383063
81MP0002277_abnormal_respiratory_mucosa0.84113907
82MP0002177_abnormal_outer_ear0.83500478
83MP0000358_abnormal_cell_content/0.81974993
84MP0001730_embryonic_growth_arrest0.80929538
85MP0000534_abnormal_ureter_morphology0.80735765
86MP0002210_abnormal_sex_determination0.80733457
87MP0002282_abnormal_trachea_morphology0.78139556
88MP0003938_abnormal_ear_development0.78008202
89MP0000350_abnormal_cell_proliferation0.77664482
90MP0002752_abnormal_somatic_nervous0.76309357
91MP0002184_abnormal_innervation0.76126690
92MP0005389_reproductive_system_phenotype0.75453368
93MP0000613_abnormal_salivary_gland0.74852463
94MP0003011_delayed_dark_adaptation0.73784611
95MP0003861_abnormal_nervous_system0.73662462
96MP0001145_abnormal_male_reproductive0.73522745
97MP0004215_abnormal_myocardial_fiber0.73403489
98MP0005391_vision/eye_phenotype0.72409634
99MP0000955_abnormal_spinal_cord0.71573562
100MP0000372_irregular_coat_pigmentation0.71504331

Predicted human phenotypes

RankGene SetZ-score
1Septo-optic dysplasia (HP:0100842)3.51463500
2Acute necrotizing encephalopathy (HP:0006965)3.43896965
3Methylmalonic acidemia (HP:0002912)3.31850280
4Abnormality of the labia minora (HP:0012880)3.25931879
5Congenital, generalized hypertrichosis (HP:0004540)3.10231554
6Acute encephalopathy (HP:0006846)3.04201399
7Abolished electroretinogram (ERG) (HP:0000550)3.01489707
8Increased hepatocellular lipid droplets (HP:0006565)2.93274297
9Progressive macrocephaly (HP:0004481)2.76954560
10Increased CSF lactate (HP:0002490)2.74613049
11Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.71483930
12Optic nerve hypoplasia (HP:0000609)2.71225210
13Abnormality of the fovea (HP:0000493)2.69728017
14Abnormal mitochondria in muscle tissue (HP:0008316)2.69080902
15Pancreatic cysts (HP:0001737)2.61367713
16Mitochondrial inheritance (HP:0001427)2.60168874
17Pendular nystagmus (HP:0012043)2.54043164
18Abnormality of the phalanges of the 5th finger (HP:0004213)2.48644207
19Lipid accumulation in hepatocytes (HP:0006561)2.45959240
20Intestinal atresia (HP:0011100)2.45808530
21Spastic diplegia (HP:0001264)2.45800218
22Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.44250477
23Volvulus (HP:0002580)2.43438782
24Aplasia/Hypoplasia of the uvula (HP:0010293)2.39379016
25True hermaphroditism (HP:0010459)2.36811175
26Colon cancer (HP:0003003)2.35902823
27Molar tooth sign on MRI (HP:0002419)2.35711849
28Abnormality of midbrain morphology (HP:0002418)2.35711849
29Cerebral edema (HP:0002181)2.30239014
30Aplasia/Hypoplasia of the fovea (HP:0008060)2.26033260
31Hypoplasia of the fovea (HP:0007750)2.26033260
32Exertional dyspnea (HP:0002875)2.21486242
33Abnormality of serum amino acid levels (HP:0003112)2.20948975
34Pancreatic fibrosis (HP:0100732)2.15593468
35Absent septum pellucidum (HP:0001331)2.14128348
36Hyperglycinemia (HP:0002154)2.13258100
37Abnormality of aspartate family amino acid metabolism (HP:0010899)2.13085748
38Central scotoma (HP:0000603)2.12856721
39Esophageal atresia (HP:0002032)2.09154207
40Gastrointestinal atresia (HP:0002589)2.09085369
41Abnormality of alanine metabolism (HP:0010916)2.07336049
42Hyperalaninemia (HP:0003348)2.07336049
43Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.07336049
44Multiple enchondromatosis (HP:0005701)2.07129496
45Small hand (HP:0200055)2.01619057
46Abnormality of methionine metabolism (HP:0010901)2.00557826
47Rhabdomyosarcoma (HP:0002859)2.00188694
48Leukodystrophy (HP:0002415)1.97560189
49Methylmalonic aciduria (HP:0012120)1.97370500
50Triphalangeal thumb (HP:0001199)1.96473611
51Renal Fanconi syndrome (HP:0001994)1.96008900
52Short tibia (HP:0005736)1.95966866
53Supernumerary spleens (HP:0009799)1.95163208
54Morphological abnormality of the middle ear (HP:0008609)1.94048592
55Decreased central vision (HP:0007663)1.91970802
56Meckel diverticulum (HP:0002245)1.91872631
57Porencephaly (HP:0002132)1.91813361
58Abnormality of the septum pellucidum (HP:0007375)1.91212685
59Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.91158970
60Dyschromatopsia (HP:0007641)1.90880415
61Biliary tract neoplasm (HP:0100574)1.88910866
62Gonadotropin excess (HP:0000837)1.87891568
63Abnormal lung lobation (HP:0002101)1.87300939
64Nephronophthisis (HP:0000090)1.86961400
653-Methylglutaconic aciduria (HP:0003535)1.85818898
66Abnormality of the ileum (HP:0001549)1.84783876
67Scotoma (HP:0000575)1.83502165
68Anophthalmia (HP:0000528)1.81382664
69Hepatocellular necrosis (HP:0001404)1.81153112
70Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.80740448
71Congenital stationary night blindness (HP:0007642)1.80230207
72Chronic bronchitis (HP:0004469)1.80065073
73Bilateral microphthalmos (HP:0007633)1.79060478
74Aplasia/Hypoplasia of the tibia (HP:0005772)1.78730438
75Abnormality of the anterior horn cell (HP:0006802)1.76761270
76Degeneration of anterior horn cells (HP:0002398)1.76761270
77Maternal diabetes (HP:0009800)1.76586971
78Abnormality of the phalanges of the 2nd finger (HP:0009541)1.76032821
79Abnormal number of incisors (HP:0011064)1.76020445
80Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.74653992
81Hyperglycinuria (HP:0003108)1.73987566
82Pancreatic islet-cell hyperplasia (HP:0004510)1.73274132
83Aplasia/hypoplasia of the uterus (HP:0008684)1.70944703
84Sclerocornea (HP:0000647)1.68716272
85Aplastic anemia (HP:0001915)1.68669173
86Stenosis of the external auditory canal (HP:0000402)1.68591505
87Absent/shortened dynein arms (HP:0200106)1.68065576
88Dynein arm defect of respiratory motile cilia (HP:0012255)1.68065576
89Agnosia (HP:0010524)1.66356488
90Hepatic necrosis (HP:0002605)1.65765624
91Cleft eyelid (HP:0000625)1.64520257
92Abnormality of glycine metabolism (HP:0010895)1.64470533
93Abnormality of serine family amino acid metabolism (HP:0010894)1.64470533
94Abnormality of the vitamin B12 metabolism (HP:0004341)1.64165811
95Amyotrophic lateral sclerosis (HP:0007354)1.63297488
96Asplenia (HP:0001746)1.63142455
97Optic disc pallor (HP:0000543)1.62813194
98Aplasia/Hypoplasia of the spleen (HP:0010451)1.61719977
99Hyperinsulinemic hypoglycemia (HP:0000825)1.61382809
100Carpal synostosis (HP:0009702)1.61050166

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK4.24762812
2MKNK23.38127837
3MKNK13.35042199
4CDC73.09631169
5SRPK12.69775918
6TRIM282.56798726
7TSSK62.44143362
8RPS6KA42.30199864
9EIF2AK32.18918175
10PNCK2.16782229
11PLK32.15763999
12MST42.12181013
13NUAK11.98693550
14NEK11.91379274
15TAF11.73314724
16WNK31.71541500
17BCR1.60295408
18ALK1.59960998
19CDK191.58105242
20ZAK1.57399037
21PLK41.52004621
22ERBB31.49472325
23STK241.48563478
24MAP4K21.47571275
25VRK21.45138292
26BMPR1B1.44915946
27TIE11.43949931
28STK38L1.41763676
29VRK11.38154060
30MAP3K121.31385307
31BMPR21.25942640
32GRK11.25663362
33DYRK21.25374465
34WEE11.25107914
35BUB11.24600555
36ADRBK21.21500651
37TTK1.18890149
38TLK11.17278872
39STK161.15540704
40STK31.15297418
41BRD41.12015605
42EIF2AK11.10892921
43PLK21.05267913
44PASK1.05158180
45CSNK1G21.05092775
46PLK11.02641298
47EIF2AK20.95785774
48MAP3K40.91913461
49CSNK1G10.86324039
50OXSR10.86319665
51NEK20.81916038
52ACVR1B0.79726450
53ATR0.79386249
54PINK10.78234478
55TEC0.77394698
56CDK30.74772308
57FLT30.73473569
58TAOK30.72095267
59YES10.68745654
60CSNK1G30.68544322
61PRKCG0.66092400
62INSRR0.64673294
63MAP3K100.62575020
64ATM0.59243037
65DYRK30.57906467
66LATS10.57070928
67DAPK10.55862597
68CDK120.55531763
69ILK0.55205135
70RPS6KA50.55128696
71MAPK130.55126037
72CDK60.54772680
73CSF1R0.54139271
74BCKDK0.53038737
75CSNK2A20.52940122
76PRKCE0.51272589
77CSNK1A1L0.50257700
78CSNK2A10.50195812
79AURKB0.49388185
80CHEK20.48644042
81MYLK0.47204435
82FRK0.44464811
83CSNK1E0.44159061
84ERBB40.40541474
85STK40.39909730
86IKBKB0.39575918
87CSNK1A10.38448715
88TGFBR10.37750711
89TXK0.37543504
90CSNK1D0.36722952
91CHEK10.35504543
92STK390.34802584
93BRSK20.34779864
94MAP2K70.34733241
95MINK10.34284451
96SGK20.33338745
97PRKDC0.31874333
98ROCK20.31806367
99NTRK10.31498978
100NME10.31306257

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030604.83568828
2Proteasome_Homo sapiens_hsa030503.57204477
3Asthma_Homo sapiens_hsa053103.25859483
4RNA degradation_Homo sapiens_hsa030182.88479376
5Spliceosome_Homo sapiens_hsa030402.82888792
6Mismatch repair_Homo sapiens_hsa034302.80352615
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.65260745
8DNA replication_Homo sapiens_hsa030302.60123852
9RNA transport_Homo sapiens_hsa030132.56699663
10RNA polymerase_Homo sapiens_hsa030202.48849436
11Oxidative phosphorylation_Homo sapiens_hsa001902.48542820
12Ribosome_Homo sapiens_hsa030102.28098827
13Basal transcription factors_Homo sapiens_hsa030222.22900272
14Parkinsons disease_Homo sapiens_hsa050122.18851816
15Homologous recombination_Homo sapiens_hsa034402.09307588
16Non-homologous end-joining_Homo sapiens_hsa034502.00563811
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.79790659
18One carbon pool by folate_Homo sapiens_hsa006701.76837413
19Type I diabetes mellitus_Homo sapiens_hsa049401.76452316
20Allograft rejection_Homo sapiens_hsa053301.74800030
21Nucleotide excision repair_Homo sapiens_hsa034201.73228998
22Autoimmune thyroid disease_Homo sapiens_hsa053201.68572327
23Maturity onset diabetes of the young_Homo sapiens_hsa049501.67648985
24Graft-versus-host disease_Homo sapiens_hsa053321.65517973
25Huntingtons disease_Homo sapiens_hsa050161.57135441
26Propanoate metabolism_Homo sapiens_hsa006401.51168004
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.50987071
28Fanconi anemia pathway_Homo sapiens_hsa034601.50220502
29mRNA surveillance pathway_Homo sapiens_hsa030151.37339219
30Alzheimers disease_Homo sapiens_hsa050101.34079229
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.28530358
32Base excision repair_Homo sapiens_hsa034101.27856313
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.23119167
34Antigen processing and presentation_Homo sapiens_hsa046121.20644410
35Cell cycle_Homo sapiens_hsa041101.19649079
36Selenocompound metabolism_Homo sapiens_hsa004501.18360986
37Cardiac muscle contraction_Homo sapiens_hsa042601.11649464
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.11274234
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.10371990
40Pyrimidine metabolism_Homo sapiens_hsa002401.07093716
41Purine metabolism_Homo sapiens_hsa002301.03292935
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.98714009
43Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.98083215
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.93688076
45Viral myocarditis_Homo sapiens_hsa054160.88277028
46Phototransduction_Homo sapiens_hsa047440.87585536
47Steroid biosynthesis_Homo sapiens_hsa001000.87292407
48Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.86238393
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.84287892
50Nicotine addiction_Homo sapiens_hsa050330.79202054
51Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.77228627
52Rheumatoid arthritis_Homo sapiens_hsa053230.76149887
53Oocyte meiosis_Homo sapiens_hsa041140.71395734
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65549947
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62603814
56Regulation of autophagy_Homo sapiens_hsa041400.62270112
57Pyruvate metabolism_Homo sapiens_hsa006200.62146168
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.61341137
59Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.59352523
60Nitrogen metabolism_Homo sapiens_hsa009100.59269252
61Basal cell carcinoma_Homo sapiens_hsa052170.56526860
62Hedgehog signaling pathway_Homo sapiens_hsa043400.54811317
63Taste transduction_Homo sapiens_hsa047420.54728361
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52972442
65Epstein-Barr virus infection_Homo sapiens_hsa051690.52815355
66Systemic lupus erythematosus_Homo sapiens_hsa053220.51877089
67p53 signaling pathway_Homo sapiens_hsa041150.50540686
68TGF-beta signaling pathway_Homo sapiens_hsa043500.49191595
69Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48726239
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46752962
71Herpes simplex infection_Homo sapiens_hsa051680.45907105
72Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.44848092
73Wnt signaling pathway_Homo sapiens_hsa043100.43671461
74Fatty acid elongation_Homo sapiens_hsa000620.42644353
75Linoleic acid metabolism_Homo sapiens_hsa005910.40607114
76Olfactory transduction_Homo sapiens_hsa047400.38596121
77Caffeine metabolism_Homo sapiens_hsa002320.38038505
78Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37483487
79Glutathione metabolism_Homo sapiens_hsa004800.37017748
80Butanoate metabolism_Homo sapiens_hsa006500.35992823
81Metabolic pathways_Homo sapiens_hsa011000.34874282
82Hippo signaling pathway_Homo sapiens_hsa043900.31728444
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.31631048
84Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.31135967
85Serotonergic synapse_Homo sapiens_hsa047260.28031321
86beta-Alanine metabolism_Homo sapiens_hsa004100.28019998
87Tryptophan metabolism_Homo sapiens_hsa003800.27447455
88Tight junction_Homo sapiens_hsa045300.26693637
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.25341111
90Hematopoietic cell lineage_Homo sapiens_hsa046400.23828894
91Legionellosis_Homo sapiens_hsa051340.23760732
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.22656597
93Chemical carcinogenesis_Homo sapiens_hsa052040.20658902
94Retinol metabolism_Homo sapiens_hsa008300.20096272
95Primary immunodeficiency_Homo sapiens_hsa053400.17278063
96Vitamin digestion and absorption_Homo sapiens_hsa049770.15991969
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.14193351
98Starch and sucrose metabolism_Homo sapiens_hsa005000.12164424
99Ether lipid metabolism_Homo sapiens_hsa005650.11594680
100Peroxisome_Homo sapiens_hsa041460.11391322

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