NAP1L1P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of inflammatory response to antigenic stimulus (GO:0002863)7.89679039
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.75682376
3regulation of hypersensitivity (GO:0002883)7.58040439
4positive regulation of mast cell activation involved in immune response (GO:0033008)6.62330999
5positive regulation of mast cell degranulation (GO:0043306)6.62330999
6ATP synthesis coupled proton transport (GO:0015986)6.57992675
7energy coupled proton transport, down electrochemical gradient (GO:0015985)6.57992675
8positive regulation of mast cell activation (GO:0033005)5.81616603
9regulation of acute inflammatory response to antigenic stimulus (GO:0002864)5.57855880
10positive regulation of protein homodimerization activity (GO:0090073)5.43920195
11positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)5.40406764
12mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.28430955
13chaperone-mediated protein transport (GO:0072321)5.16708037
14regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)4.94536346
15platelet dense granule organization (GO:0060155)4.94380617
16respiratory electron transport chain (GO:0022904)4.66735805
17establishment of protein localization to mitochondrial membrane (GO:0090151)4.62669964
18positive regulation of myeloid leukocyte mediated immunity (GO:0002888)4.62131446
19viral transcription (GO:0019083)4.60349899
20electron transport chain (GO:0022900)4.54008262
21protein maturation by protein folding (GO:0022417)4.52385356
22ribosomal small subunit assembly (GO:0000028)4.52379216
23positive regulation of leukocyte degranulation (GO:0043302)4.49696702
24translational termination (GO:0006415)4.41496046
25response to pheromone (GO:0019236)4.41351124
26mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.27081408
27mitochondrial respiratory chain complex I assembly (GO:0032981)4.27081408
28NADH dehydrogenase complex assembly (GO:0010257)4.27081408
29negative regulation of heart rate (GO:0010459)4.26987397
30hepatocyte differentiation (GO:0070365)4.21143837
31monoamine transport (GO:0015844)4.19600139
32positive regulation of immunoglobulin mediated immune response (GO:0002891)4.17877050
33positive regulation of B cell mediated immunity (GO:0002714)4.17877050
34SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.08149026
35immunoglobulin mediated immune response (GO:0016064)4.05728417
36regulation of inflammatory response to antigenic stimulus (GO:0002861)4.05242826
37protein complex biogenesis (GO:0070271)4.01167848
38protein targeting to ER (GO:0045047)4.00605932
39cotranslational protein targeting to membrane (GO:0006613)3.98569312
40ribosomal large subunit biogenesis (GO:0042273)3.90144342
41establishment of protein localization to endoplasmic reticulum (GO:0072599)3.81760134
42negative regulation of calcium ion transport into cytosol (GO:0010523)3.81154526
43proteasome assembly (GO:0043248)3.80848782
44ATP biosynthetic process (GO:0006754)3.79550974
45protein localization to endoplasmic reticulum (GO:0070972)3.79186650
46dopamine transport (GO:0015872)3.75194237
47mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.68773855
48positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.68773855
49B cell mediated immunity (GO:0019724)3.61464317
50mitochondrial respiratory chain complex assembly (GO:0033108)3.61415810
51translational elongation (GO:0006414)3.60263547
52negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.50888010
53GPI anchor biosynthetic process (GO:0006506)3.47653718
54viral life cycle (GO:0019058)3.45897139
55icosanoid secretion (GO:0032309)3.43819846
56arachidonic acid secretion (GO:0050482)3.43819846
57regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.38855870
58response to vitamin E (GO:0033197)3.32972641
59hydrogen ion transmembrane transport (GO:1902600)3.29270088
60cellular protein complex disassembly (GO:0043624)3.28659804
61regulation of mast cell activation (GO:0033003)3.20879482
62preassembly of GPI anchor in ER membrane (GO:0016254)3.20309720
63secondary heart field specification (GO:0003139)3.19125244
64heart field specification (GO:0003128)3.19125244
65maturation of SSU-rRNA (GO:0030490)3.17376954
66positive regulation of acute inflammatory response (GO:0002675)3.16608014
67translational initiation (GO:0006413)3.13410728
68GPI anchor metabolic process (GO:0006505)3.13048085
69regulation of mast cell degranulation (GO:0043304)3.12840121
70positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.12296934
71respiratory chain complex IV assembly (GO:0008535)3.11468697
72nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.11354506
73neutrophil activation involved in immune response (GO:0002283)3.06661755
74skeletal muscle tissue regeneration (GO:0043403)3.05467735
75nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.02383774
76purine nucleoside triphosphate biosynthetic process (GO:0009145)3.00203914
77modulation of growth of symbiont involved in interaction with host (GO:0044144)3.00041579
78regulation of growth of symbiont in host (GO:0044126)3.00041579
79negative regulation of growth of symbiont in host (GO:0044130)3.00041579
80negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.00041579
81purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.98205876
82galactose catabolic process (GO:0019388)2.96836876
83regulation of mast cell activation involved in immune response (GO:0033006)2.94795172
84translation (GO:0006412)2.94454947
85neuronal action potential propagation (GO:0019227)2.93535591
86positive regulation of regulated secretory pathway (GO:1903307)2.91812819
87protein targeting to membrane (GO:0006612)2.89496340
88exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.89040692
89positive regulation of chemokine biosynthetic process (GO:0045080)2.86925287
90protein peptidyl-prolyl isomerization (GO:0000413)2.86117307
91regulation of chronic inflammatory response (GO:0002676)2.85666669
92aldehyde catabolic process (GO:0046185)2.80298999
93regulation of myeloid cell apoptotic process (GO:0033032)2.77795183
94proton transport (GO:0015992)2.77552738
95positive regulation of vesicle fusion (GO:0031340)2.76926178
96fatty acid derivative transport (GO:1901571)2.76773829
97icosanoid transport (GO:0071715)2.76773829
98viral mRNA export from host cell nucleus (GO:0046784)2.76264380
99negative regulation of acute inflammatory response (GO:0002674)2.76088295
100heart trabecula morphogenesis (GO:0061384)2.75876265

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.71977877
2VDR_22108803_ChIP-Seq_LS180_Human3.85193563
3TAF15_26573619_Chip-Seq_HEK293_Human3.78028778
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.43369979
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.17827393
6FLI1_27457419_Chip-Seq_LIVER_Mouse3.05178411
7BP1_19119308_ChIP-ChIP_Hs578T_Human2.91828654
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.83848709
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.77598356
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.49917114
11PCGF2_27294783_Chip-Seq_ESCs_Mouse2.43537946
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.33961980
13PCGF2_27294783_Chip-Seq_NPCs_Mouse2.18252617
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.08046499
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.05401097
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.05024282
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.04392587
18EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.03610656
19P300_19829295_ChIP-Seq_ESCs_Human2.03398505
20EWS_26573619_Chip-Seq_HEK293_Human2.00727188
21VDR_23849224_ChIP-Seq_CD4+_Human1.98998158
22ELK1_19687146_ChIP-ChIP_HELA_Human1.93396061
23SUZ12_27294783_Chip-Seq_NPCs_Mouse1.78968475
24RBPJ_22232070_ChIP-Seq_NCS_Mouse1.75780907
25MYC_18555785_ChIP-Seq_MESCs_Mouse1.69415958
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.66028181
27HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.63574867
28SOX2_19829295_ChIP-Seq_ESCs_Human1.63036855
29NANOG_19829295_ChIP-Seq_ESCs_Human1.63036855
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.61431830
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.56431883
32IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.52734381
33NFE2_27457419_Chip-Seq_LIVER_Mouse1.51365382
34BMI1_23680149_ChIP-Seq_NPCS_Mouse1.48618008
35FUS_26573619_Chip-Seq_HEK293_Human1.48037634
36FOXA1_27270436_Chip-Seq_PROSTATE_Human1.46996805
37FOXA1_25329375_ChIP-Seq_VCAP_Human1.46996805
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.45759110
39CRX_20693478_ChIP-Seq_RETINA_Mouse1.45113072
40MYC_18940864_ChIP-ChIP_HL60_Human1.42888912
41GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.39585802
42RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.39085630
43ER_23166858_ChIP-Seq_MCF-7_Human1.38432185
44ZNF274_21170338_ChIP-Seq_K562_Hela1.36897289
45JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.36696625
46TP53_22573176_ChIP-Seq_HFKS_Human1.36077543
47MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.35966927
48ETV2_25802403_ChIP-Seq_MESCs_Mouse1.35156584
49EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.31700795
50EZH2_27294783_Chip-Seq_NPCs_Mouse1.28944669
51GATA3_26560356_Chip-Seq_TH2_Human1.27541428
52FOXH1_21741376_ChIP-Seq_EPCs_Human1.24208533
53CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.19687590
54FOXA1_21572438_ChIP-Seq_LNCaP_Human1.16742158
55CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.16647112
56P53_22387025_ChIP-Seq_ESCs_Mouse1.16500890
57CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.16462130
58AR_20517297_ChIP-Seq_VCAP_Human1.16063442
59ETS1_20019798_ChIP-Seq_JURKAT_Human1.15991265
60UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15853412
61CBX2_27304074_Chip-Seq_ESCs_Mouse1.15680852
62EZH2_22144423_ChIP-Seq_EOC_Human1.14254748
63PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13538063
64GATA6_21074721_ChIP-Seq_CACO-2_Human1.12385465
65ERG_20517297_ChIP-Seq_VCAP_Human1.12354415
66CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12275084
67SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.11803282
68SALL4_22934838_ChIP-ChIP_CD34+_Human1.11760037
69PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.08894476
70OCT4_21477851_ChIP-Seq_ESCs_Mouse1.08572243
71GATA3_26560356_Chip-Seq_TH1_Human1.05311361
72STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.04937976
73CMYC_18555785_Chip-Seq_ESCs_Mouse1.04790202
74RBPJ_21746931_ChIP-Seq_IB4_Human1.04770954
75IGF1R_20145208_ChIP-Seq_DFB_Human1.04583800
76GATA3_21878914_ChIP-Seq_MCF-7_Human1.04317612
77CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.03952316
78IRF8_21731497_ChIP-ChIP_J774_Mouse1.02810574
79LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02526432
80MYC_19829295_ChIP-Seq_ESCs_Human1.02431485
81GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.01192275
82AR_25329375_ChIP-Seq_VCAP_Human1.00049338
83NANOG_18555785_Chip-Seq_ESCs_Mouse0.99870852
84E2F1_18555785_Chip-Seq_ESCs_Mouse0.99843163
85IRF8_22096565_ChIP-ChIP_GC-B_Human0.95789819
86SMAD4_21799915_ChIP-Seq_A2780_Human0.95589679
87CIITA_25753668_ChIP-Seq_RAJI_Human0.94445785
88KLF5_20875108_ChIP-Seq_MESCs_Mouse0.93463114
89EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93144838
90OCT4_18555785_Chip-Seq_ESCs_Mouse0.92142579
91HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.91762400
92CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.91697161
93CTCF_18555785_Chip-Seq_ESCs_Mouse0.91555179
94P300_18555785_Chip-Seq_ESCs_Mouse0.91431149
95SMAD1_18555785_Chip-Seq_ESCs_Mouse0.91122017
96POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.90181608
97BCAT_22108803_ChIP-Seq_LS180_Human0.89475365
98SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89404613
99AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89379416
100PIAS1_25552417_ChIP-Seq_VCAP_Human0.89199360

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.38572679
2MP0009379_abnormal_foot_pigmentation4.17045844
3MP0004147_increased_porphyrin_level3.84372701
4MP0005671_abnormal_response_to3.01692417
5MP0006292_abnormal_olfactory_placode2.51955113
6MP0009333_abnormal_splenocyte_physiolog2.27077176
7MP0005367_renal/urinary_system_phenotyp2.26465643
8MP0000516_abnormal_urinary_system2.26465643
9MP0002234_abnormal_pharynx_morphology2.02282365
10MP0009785_altered_susceptibility_to1.98334310
11MP0008872_abnormal_physiological_respon1.97315746
12MP0000685_abnormal_immune_system1.94988931
13MP0005646_abnormal_pituitary_gland1.94061831
14MP0002163_abnormal_gland_morphology1.93052626
15MP0001800_abnormal_humoral_immune1.92846671
16MP0001873_stomach_inflammation1.90318284
17MP0008995_early_reproductive_senescence1.76358747
18MP0009764_decreased_sensitivity_to1.73039999
19MP0006036_abnormal_mitochondrial_physio1.68487088
20MP0002148_abnormal_hypersensitivity_rea1.66661671
21MP0001905_abnormal_dopamine_level1.61007615
22MP0003724_increased_susceptibility_to1.53533611
23MP0000372_irregular_coat_pigmentation1.53475157
24MP0005551_abnormal_eye_electrophysiolog1.53303383
25MP0002138_abnormal_hepatobiliary_system1.52050201
26MP0002102_abnormal_ear_morphology1.50145797
27MP0001986_abnormal_taste_sensitivity1.47367310
28MP0002736_abnormal_nociception_after1.45614005
29MP0005645_abnormal_hypothalamus_physiol1.41132945
30MP0000427_abnormal_hair_cycle1.38462502
31MP0005000_abnormal_immune_tolerance1.34285785
32MP0004381_abnormal_hair_follicle1.31089058
33MP0001765_abnormal_ion_homeostasis1.30905102
34MP0005387_immune_system_phenotype1.30721571
35MP0001790_abnormal_immune_system1.30721571
36MP0003950_abnormal_plasma_membrane1.30690830
37MP0002452_abnormal_antigen_presenting1.27752336
38MP0002837_dystrophic_cardiac_calcinosis1.25770735
39MP0004019_abnormal_vitamin_homeostasis1.25127790
40MP0006276_abnormal_autonomic_nervous1.24831216
41MP0002166_altered_tumor_susceptibility1.24193135
42MP0001919_abnormal_reproductive_system1.23261489
43MP0004145_abnormal_muscle_electrophysio1.21916819
44MP0001529_abnormal_vocalization1.21121379
45MP0003195_calcinosis1.18776782
46MP0001486_abnormal_startle_reflex1.16541133
47MP0003567_abnormal_fetal_cardiomyocyte1.16160106
48MP0003075_altered_response_to1.16009291
49MP0003011_delayed_dark_adaptation1.15834442
50MP0000647_abnormal_sebaceous_gland1.15196850
51MP0010155_abnormal_intestine_physiology1.09768785
52MP0005166_decreased_susceptibility_to1.09691544
53MP0002723_abnormal_immune_serum1.06382632
54MP0002277_abnormal_respiratory_mucosa1.05564693
55MP0002751_abnormal_autonomic_nervous1.05157912
56MP0000383_abnormal_hair_follicle1.04949305
57MP0005379_endocrine/exocrine_gland_phen1.04529817
58MP0005253_abnormal_eye_physiology1.03797055
59MP0009053_abnormal_anal_canal1.03203479
60MP0008875_abnormal_xenobiotic_pharmacok1.02915220
61MP0004142_abnormal_muscle_tone1.00489977
62MP0003436_decreased_susceptibility_to0.98868557
63MP0003638_abnormal_response/metabolism_0.97383182
64MP0002090_abnormal_vision0.97075158
65MP0006072_abnormal_retinal_apoptosis0.96072938
66MP0005389_reproductive_system_phenotype0.95704341
67MP0002006_tumorigenesis0.95556312
68MP0005636_abnormal_mineral_homeostasis0.92236816
69MP0003866_abnormal_defecation0.91812988
70MP0002735_abnormal_chemical_nociception0.91692187
71MP0000569_abnormal_digit_pigmentation0.91134127
72MP0001968_abnormal_touch/_nociception0.90497283
73MP0009046_muscle_twitch0.89728668
74MP0008961_abnormal_basal_metabolism0.88282291
75MP0000343_altered_response_to0.88157272
76MP0005025_abnormal_response_to0.87674182
77MP0002420_abnormal_adaptive_immunity0.86988595
78MP0001664_abnormal_digestion0.85769347
79MP0003252_abnormal_bile_duct0.84960885
80MP0009745_abnormal_behavioral_response0.84629698
81MP0001819_abnormal_immune_cell0.84219873
82MP0004085_abnormal_heartbeat0.83957352
83MP0006054_spinal_hemorrhage0.83129624
84MP0000537_abnormal_urethra_morphology0.82607079
85MP0002282_abnormal_trachea_morphology0.80904817
86MP0000230_abnormal_systemic_arterial0.79621288
87MP0006035_abnormal_mitochondrial_morpho0.78823103
88MP0002734_abnormal_mechanical_nocicepti0.78556841
89MP0001970_abnormal_pain_threshold0.77985116
90MP0004084_abnormal_cardiac_muscle0.77913979
91MP0002272_abnormal_nervous_system0.77167579
92MP0006082_CNS_inflammation0.76830014
93MP0003938_abnormal_ear_development0.76303968
94MP0005647_abnormal_sex_gland0.75796207
95MP0001845_abnormal_inflammatory_respons0.74997135
96MP0002160_abnormal_reproductive_system0.74850722
97MP0001286_abnormal_eye_development0.73334834
98MP0008058_abnormal_DNA_repair0.72725417
99MP0003186_abnormal_redox_activity0.72581961
100MP0005377_hearing/vestibular/ear_phenot0.71600331

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.39485591
2Acute encephalopathy (HP:0006846)5.66199774
3Mitochondrial inheritance (HP:0001427)5.49568771
4Progressive macrocephaly (HP:0004481)5.37903756
5Abnormal mitochondria in muscle tissue (HP:0008316)5.36510162
6Increased CSF lactate (HP:0002490)5.22910850
7Lipid accumulation in hepatocytes (HP:0006561)4.97427025
8Increased hepatocellular lipid droplets (HP:0006565)4.96024943
9Hypothermia (HP:0002045)4.61106634
10Hepatocellular necrosis (HP:0001404)4.56943967
11Exertional dyspnea (HP:0002875)4.27997788
12Cerebral edema (HP:0002181)4.21027209
13Congenital, generalized hypertrichosis (HP:0004540)4.08667920
14Renal Fanconi syndrome (HP:0001994)3.74160809
15Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.63567289
16Hepatic necrosis (HP:0002605)3.62708177
17Large eyes (HP:0001090)3.31183107
18Chronic sinusitis (HP:0011109)3.26138669
19Leukodystrophy (HP:0002415)3.25228498
20Azoospermia (HP:0000027)3.09424580
21Premature ovarian failure (HP:0008209)3.07938895
22Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.99024527
23Sensory axonal neuropathy (HP:0003390)2.78320537
24Optic disc pallor (HP:0000543)2.69685422
25Exercise intolerance (HP:0003546)2.69063962
26Abnormality of renal resorption (HP:0011038)2.67623488
27Supernumerary spleens (HP:0009799)2.65061881
28Reduced antithrombin III activity (HP:0001976)2.59832959
29Concave nail (HP:0001598)2.57836901
30Hypoalphalipoproteinemia (HP:0003233)2.57021413
31Increased intramyocellular lipid droplets (HP:0012240)2.52543395
32Dynein arm defect of respiratory motile cilia (HP:0012255)2.43906598
33Absent/shortened dynein arms (HP:0200106)2.43906598
34Testicular atrophy (HP:0000029)2.43364519
35Respiratory failure (HP:0002878)2.38783541
36CNS demyelination (HP:0007305)2.37263707
37Hyperphosphaturia (HP:0003109)2.32857484
38Febrile seizures (HP:0002373)2.31898360
39Increased muscle lipid content (HP:0009058)2.31837992
40Pulmonary infiltrates (HP:0002113)2.31502535
41Poor head control (HP:0002421)2.27663747
42Abnormality of aspartate family amino acid metabolism (HP:0010899)2.26417805
43Abnormal respiratory motile cilium physiology (HP:0012261)2.21664256
44Large for gestational age (HP:0001520)2.19386921
45Constricted visual fields (HP:0001133)2.17137870
46Increased serum lactate (HP:0002151)2.16579922
47Rib fusion (HP:0000902)2.14613714
48Abnormal ciliary motility (HP:0012262)2.14136047
49Decreased activity of mitochondrial respiratory chain (HP:0008972)2.12671829
50Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.12671829
51Reticulocytopenia (HP:0001896)2.07165735
52Respiratory difficulties (HP:0002880)2.05572065
53Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.04709009
54Arthropathy (HP:0003040)2.04261379
55Abnormal respiratory epithelium morphology (HP:0012253)2.01818611
56Abnormal respiratory motile cilium morphology (HP:0005938)2.01818611
57Glycosuria (HP:0003076)2.00521996
58Abnormality of urine glucose concentration (HP:0011016)2.00521996
59Abnormal spermatogenesis (HP:0008669)1.99848101
60Pallor (HP:0000980)1.98838998
61Abnormality of macular pigmentation (HP:0008002)1.98268149
62Tetany (HP:0001281)1.97936019
63Absent hand (HP:0004050)1.97610545
64Gangrene (HP:0100758)1.97242092
65Woolly hair (HP:0002224)1.96947363
66Ureteral stenosis (HP:0000071)1.96038428
67Intestinal atresia (HP:0011100)1.92610121
68Congenital ichthyosiform erythroderma (HP:0007431)1.92463340
69Renal tubular dysfunction (HP:0000124)1.90565212
70Oral leukoplakia (HP:0002745)1.89859915
71Lethargy (HP:0001254)1.89595189
72Hypomagnesemia (HP:0002917)1.86417860
73Ureteral obstruction (HP:0006000)1.84961831
74Chronic bronchitis (HP:0004469)1.84666410
75Alveolar cell carcinoma (HP:0006519)1.84146044
76Volvulus (HP:0002580)1.82854724
77Macrocytic anemia (HP:0001972)1.81638443
78Symptomatic seizures (HP:0011145)1.80734241
79Abnormality of the phalanges of the 2nd finger (HP:0009541)1.79975172
80Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.77773909
81Lactic acidosis (HP:0003128)1.77709909
82Neoplasm of the tracheobronchial system (HP:0100552)1.76674630
83Abnormal urine phosphate concentration (HP:0012599)1.76606190
84Tongue fasciculations (HP:0001308)1.76338001
85Onycholysis (HP:0001806)1.75705985
86Abnormality of the prostate (HP:0008775)1.75134204
87Type II lissencephaly (HP:0007260)1.71526138
88Abnormality of the phalanges of the 5th finger (HP:0004213)1.69431160
89Abnormality of dental color (HP:0011073)1.69230845
90Abnormality of cells of the erythroid lineage (HP:0012130)1.69105376
91Short chin (HP:0000331)1.67794912
92Myotonia (HP:0002486)1.66952530
93X-linked dominant inheritance (HP:0001423)1.66775607
94Aplasia/hypoplasia of the uterus (HP:0008684)1.65782925
95Pancreatic cysts (HP:0001737)1.64939452
96Polyneuropathy (HP:0001271)1.62508623
97Parakeratosis (HP:0001036)1.62361805
98Short tibia (HP:0005736)1.61524706
99Abnormality of the pleura (HP:0002103)1.61450998
100Resting tremor (HP:0002322)1.60967346

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K125.79025031
2BMPR24.45126032
3STK163.43083507
4MYLK3.05883104
5ILK2.78085365
6ERBB32.74616201
7TLK12.68941610
8BLK2.64844199
9TAOK32.52815635
10CDK192.43192025
11DAPK12.38449320
12STK38L2.19866666
13TRPM72.09101726
14TRIM282.00070394
15DAPK31.95856437
16SCYL21.92216873
17DAPK21.72792308
18PIK3CG1.60232403
19MKNK21.56141283
20ACVR1B1.54705662
21RIPK41.47774598
22NME11.47294931
23GRK11.47196312
24TIE11.38884997
25BUB11.37155212
26STK391.34679607
27MKNK11.34578590
28OXSR11.28120662
29SIK31.26268882
30GRK61.25929824
31FRK1.25409903
32CDK81.23878953
33MAP4K21.18468009
34ERBB41.06760280
35MATK1.03298505
36MAP4K11.01024450
37EIF2AK30.95622747
38PAK40.93635000
39MAPKAPK30.90698723
40LYN0.84932121
41CSF1R0.84917301
42GRK50.82869390
43ROCK10.77463826
44TEC0.73785717
45INSRR0.73585345
46PRKCG0.72642078
47ERBB20.72571674
48SYK0.68839900
49AURKB0.68574746
50PRKCE0.67849812
51MST40.67752284
52PRKD30.67369500
53OBSCN0.62363604
54WNK30.61959916
55PRKG10.61736991
56TXK0.61698491
57ADRBK20.61134692
58IKBKB0.60148428
59VRK20.59861155
60MAPK130.57936775
61KIT0.57329412
62IGF1R0.56413200
63PKN10.55995295
64PHKG20.55677106
65PHKG10.55677106
66EIF2AK20.55603515
67EPHB20.55459811
68BMPR1B0.53067835
69CAMKK20.51380150
70FLT30.49561086
71MARK30.48398920
72EGFR0.48263411
73WNK40.46664959
74GRK70.46581058
75ROCK20.46233863
76STK240.45248962
77NUAK10.40855277
78ABL10.40680017
79FES0.38919267
80CAMK2D0.37495467
81PRKACA0.37432080
82PASK0.35688484
83VRK10.35535745
84PRKACB0.34792341
85PRKCA0.34736973
86CSNK2A20.34391377
87CAMK2G0.34198621
88CAMK2B0.33464932
89DYRK20.31926731
90PRKACG0.31608561
91LCK0.31341495
92HCK0.31094558
93STK30.30234079
94PRKCB0.29389174
95CAMK2A0.28738130
96PRKCD0.28330316
97MUSK0.27809158
98IRAK10.25823977
99SIK20.25555128
100JAK10.25133282

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053106.58078177
2Allograft rejection_Homo sapiens_hsa053303.95408004
3Oxidative phosphorylation_Homo sapiens_hsa001903.81239150
4Autoimmune thyroid disease_Homo sapiens_hsa053203.80530414
5Type I diabetes mellitus_Homo sapiens_hsa049403.68198661
6Graft-versus-host disease_Homo sapiens_hsa053323.68069493
7Intestinal immune network for IgA production_Homo sapiens_hsa046723.45939436
8Ribosome_Homo sapiens_hsa030103.21658274
9Parkinsons disease_Homo sapiens_hsa050123.17965935
10Proteasome_Homo sapiens_hsa030502.70781842
11Staphylococcus aureus infection_Homo sapiens_hsa051502.24326659
12Alzheimers disease_Homo sapiens_hsa050102.23311422
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.18461252
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.03208832
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.96388720
16Huntingtons disease_Homo sapiens_hsa050161.95128147
17Rheumatoid arthritis_Homo sapiens_hsa053231.91042624
18Protein export_Homo sapiens_hsa030601.82712628
19Cardiac muscle contraction_Homo sapiens_hsa042601.77414793
20Viral myocarditis_Homo sapiens_hsa054161.77369198
21Antigen processing and presentation_Homo sapiens_hsa046121.75102807
22Leishmaniasis_Homo sapiens_hsa051401.48741220
23Homologous recombination_Homo sapiens_hsa034401.34642544
24Systemic lupus erythematosus_Homo sapiens_hsa053221.32315539
25One carbon pool by folate_Homo sapiens_hsa006701.31758495
26Hematopoietic cell lineage_Homo sapiens_hsa046401.03029295
27Collecting duct acid secretion_Homo sapiens_hsa049660.98777104
28Tuberculosis_Homo sapiens_hsa051520.89747874
29Regulation of autophagy_Homo sapiens_hsa041400.89647803
30Nucleotide excision repair_Homo sapiens_hsa034200.86739219
31Glutathione metabolism_Homo sapiens_hsa004800.85749847
32Maturity onset diabetes of the young_Homo sapiens_hsa049500.85354825
33Basal transcription factors_Homo sapiens_hsa030220.83063361
34Olfactory transduction_Homo sapiens_hsa047400.77901019
35Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76145006
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.73802977
37Legionellosis_Homo sapiens_hsa051340.72248026
38RNA degradation_Homo sapiens_hsa030180.71613377
39Phototransduction_Homo sapiens_hsa047440.70951711
40Phagosome_Homo sapiens_hsa041450.67924091
41RNA polymerase_Homo sapiens_hsa030200.64788331
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.60707543
43Selenocompound metabolism_Homo sapiens_hsa004500.59082326
44Non-homologous end-joining_Homo sapiens_hsa034500.56890661
45Toxoplasmosis_Homo sapiens_hsa051450.53021435
46Herpes simplex infection_Homo sapiens_hsa051680.52774934
47Nitrogen metabolism_Homo sapiens_hsa009100.52000605
48Influenza A_Homo sapiens_hsa051640.48751506
49NF-kappa B signaling pathway_Homo sapiens_hsa040640.47415820
50Arachidonic acid metabolism_Homo sapiens_hsa005900.47172604
51Chemical carcinogenesis_Homo sapiens_hsa052040.46855510
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.45403444
53Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44742345
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42799956
55African trypanosomiasis_Homo sapiens_hsa051430.42263025
56RNA transport_Homo sapiens_hsa030130.40926059
57Retinol metabolism_Homo sapiens_hsa008300.39125718
58Nicotine addiction_Homo sapiens_hsa050330.37572714
59Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36470378
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36133293
61Base excision repair_Homo sapiens_hsa034100.33801395
62Spliceosome_Homo sapiens_hsa030400.32981357
63Steroid hormone biosynthesis_Homo sapiens_hsa001400.32451877
64Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.32189548
65Taste transduction_Homo sapiens_hsa047420.32143621
66Salivary secretion_Homo sapiens_hsa049700.30880314
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.29898547
68Primary immunodeficiency_Homo sapiens_hsa053400.28714581
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.28177805
70Drug metabolism - other enzymes_Homo sapiens_hsa009830.28032720
71Linoleic acid metabolism_Homo sapiens_hsa005910.27721169
72Epstein-Barr virus infection_Homo sapiens_hsa051690.27554097
73Morphine addiction_Homo sapiens_hsa050320.27281839
74Purine metabolism_Homo sapiens_hsa002300.27070535
75Vitamin digestion and absorption_Homo sapiens_hsa049770.20335110
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.20004030
77Metabolic pathways_Homo sapiens_hsa011000.19776258
78Peroxisome_Homo sapiens_hsa041460.19562552
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.19173461
80Caffeine metabolism_Homo sapiens_hsa002320.17592299
81Galactose metabolism_Homo sapiens_hsa000520.16906527
82alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.16406205
83Mismatch repair_Homo sapiens_hsa034300.16290740
84Fanconi anemia pathway_Homo sapiens_hsa034600.15769780
85Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.14319315
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.14212927
87Tryptophan metabolism_Homo sapiens_hsa003800.13420677
88Amphetamine addiction_Homo sapiens_hsa050310.11806101
89Pyrimidine metabolism_Homo sapiens_hsa002400.10736730
90GABAergic synapse_Homo sapiens_hsa047270.10631323
91Pentose and glucuronate interconversions_Homo sapiens_hsa000400.10059149
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.08684622
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.08577583
94DNA replication_Homo sapiens_hsa030300.08400612
95Circadian entrainment_Homo sapiens_hsa047130.07278526
96Malaria_Homo sapiens_hsa051440.06920349
97Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.06276294
98Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.05874047
99Pertussis_Homo sapiens_hsa051330.05115137
100Salmonella infection_Homo sapiens_hsa051320.04867298

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