NAP1L1P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)8.70071594
2viral transcription (GO:0019083)7.24643128
3ribosomal small subunit biogenesis (GO:0042274)7.21031064
4translational termination (GO:0006415)7.03832834
5ribosomal large subunit biogenesis (GO:0042273)6.34587407
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.97109454
7translational elongation (GO:0006414)5.94836487
8cotranslational protein targeting to membrane (GO:0006613)5.86936888
9protein targeting to ER (GO:0045047)5.84117413
10establishment of protein localization to endoplasmic reticulum (GO:0072599)5.65540131
11protein localization to endoplasmic reticulum (GO:0070972)5.50018036
12cellular protein complex disassembly (GO:0043624)5.33293442
13viral life cycle (GO:0019058)5.26111611
14nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.18256617
15translational initiation (GO:0006413)4.94054472
16regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.70762239
17protein complex disassembly (GO:0043241)4.39607485
18maturation of SSU-rRNA (GO:0030490)4.37158043
19water-soluble vitamin biosynthetic process (GO:0042364)4.34408120
20behavioral response to nicotine (GO:0035095)4.28970661
21macromolecular complex disassembly (GO:0032984)4.16640041
22ncRNA 3-end processing (GO:0043628)4.11793919
23axoneme assembly (GO:0035082)3.96812597
24mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.94208754
25translation (GO:0006412)3.84602028
26protein targeting to membrane (GO:0006612)3.74869258
27nonmotile primary cilium assembly (GO:0035058)3.73469191
28nuclear-transcribed mRNA catabolic process (GO:0000956)3.71907811
29ribonucleoprotein complex biogenesis (GO:0022613)3.67313714
30mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.62337870
31establishment of protein localization to mitochondrial membrane (GO:0090151)3.56695563
32ATP synthesis coupled proton transport (GO:0015986)3.47342289
33energy coupled proton transport, down electrochemical gradient (GO:0015985)3.47342289
34mRNA catabolic process (GO:0006402)3.46352809
35chromatin remodeling at centromere (GO:0031055)3.41611101
36protein neddylation (GO:0045116)3.37420358
37cellular component biogenesis (GO:0044085)3.33617571
38kidney morphogenesis (GO:0060993)3.31499547
39mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.15208739
40mitochondrial respiratory chain complex I assembly (GO:0032981)3.15208739
41NADH dehydrogenase complex assembly (GO:0010257)3.15208739
42exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.13125133
43DNA deamination (GO:0045006)3.12084075
44nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.12058725
45RNA catabolic process (GO:0006401)3.10238902
46CENP-A containing nucleosome assembly (GO:0034080)3.09214334
47deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.07696476
48neuron fate determination (GO:0048664)3.06511361
49negative regulation of T cell differentiation in thymus (GO:0033085)3.04634379
50protein complex biogenesis (GO:0070271)3.01861309
51segment specification (GO:0007379)3.01023111
52rRNA processing (GO:0006364)2.98414637
53protein polyglutamylation (GO:0018095)2.96032357
54forebrain morphogenesis (GO:0048853)2.95182733
55cell proliferation in forebrain (GO:0021846)2.92386958
56chaperone-mediated protein transport (GO:0072321)2.91522974
57GPI anchor metabolic process (GO:0006505)2.90663260
58respiratory electron transport chain (GO:0022904)2.88304601
59rRNA metabolic process (GO:0016072)2.86533131
60regulation of interleukin-12 biosynthetic process (GO:0045075)2.85160442
61electron transport chain (GO:0022900)2.82496753
62mitochondrial respiratory chain complex assembly (GO:0033108)2.79434814
63pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.77212979
64protein-cofactor linkage (GO:0018065)2.75981982
65GMP metabolic process (GO:0046037)2.75152752
66preassembly of GPI anchor in ER membrane (GO:0016254)2.74352446
67regulation of mesoderm development (GO:2000380)2.73148480
68centriole replication (GO:0007099)2.72505315
69GPI anchor biosynthetic process (GO:0006506)2.71994170
70positive regulation of respiratory burst (GO:0060267)2.60626048
71response to xenobiotic stimulus (GO:0009410)2.57920394
72establishment of protein localization to membrane (GO:0090150)2.52891078
73replication fork processing (GO:0031297)2.52685352
74establishment of planar polarity (GO:0001736)2.51978833
75establishment of tissue polarity (GO:0007164)2.51978833
76transcription elongation from RNA polymerase III promoter (GO:0006385)2.48654841
77termination of RNA polymerase III transcription (GO:0006386)2.48654841
78cellular response to dexamethasone stimulus (GO:0071549)2.48000656
79protein targeting (GO:0006605)2.47719607
80inositol phosphate dephosphorylation (GO:0046855)2.44370816
81phosphorylated carbohydrate dephosphorylation (GO:0046838)2.44370816
82peptidyl-histidine modification (GO:0018202)2.42667234
83purine-containing compound salvage (GO:0043101)2.41281797
84positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.40592796
85DNA double-strand break processing (GO:0000729)2.39669725
86recombinational repair (GO:0000725)2.38745334
87histone exchange (GO:0043486)2.37577548
88activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.37014293
89protein targeting to mitochondrion (GO:0006626)2.36516073
90establishment of protein localization to organelle (GO:0072594)2.35925793
91pattern specification involved in kidney development (GO:0061004)2.35407585
92response to pheromone (GO:0019236)2.34352856
93negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.32629780
94establishment of protein localization to mitochondrion (GO:0072655)2.32126271
95positive regulation of meiosis (GO:0045836)2.31220156
96intracellular protein transmembrane import (GO:0044743)2.31159314
97otic vesicle formation (GO:0030916)2.30982963
98inositol phosphate catabolic process (GO:0071545)2.30790948
99cilium movement (GO:0003341)2.28747086
100response to nitrosative stress (GO:0051409)2.28471228

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human3.90984837
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.35128514
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.31248177
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.26294875
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.03314734
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.01202110
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.93380189
8VDR_22108803_ChIP-Seq_LS180_Human2.92217844
9FUS_26573619_Chip-Seq_HEK293_Human2.74805717
10EWS_26573619_Chip-Seq_HEK293_Human2.63364507
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.56535793
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.51842693
13EZH2_22144423_ChIP-Seq_EOC_Human2.40413159
14ZNF274_21170338_ChIP-Seq_K562_Hela2.32547077
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.29321648
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.26381023
17ELK1_19687146_ChIP-ChIP_HELA_Human2.02856113
18VDR_23849224_ChIP-Seq_CD4+_Human2.01006682
19ETS1_20019798_ChIP-Seq_JURKAT_Human2.00241570
20RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.93532804
21MYC_18940864_ChIP-ChIP_HL60_Human1.88116006
22BMI1_23680149_ChIP-Seq_NPCS_Mouse1.84549373
23TAF15_26573619_Chip-Seq_HEK293_Human1.82927832
24CTBP1_25329375_ChIP-Seq_LNCAP_Human1.80826377
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.79703189
26POU5F1_16153702_ChIP-ChIP_HESCs_Human1.78067000
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.76375891
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.73375337
29P300_19829295_ChIP-Seq_ESCs_Human1.72746727
30CBX2_27304074_Chip-Seq_ESCs_Mouse1.71800755
31EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.67454827
32E2F4_17652178_ChIP-ChIP_JURKAT_Human1.66306139
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.63823323
34JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.62178627
35GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.60182662
36HTT_18923047_ChIP-ChIP_STHdh_Human1.55454856
37IGF1R_20145208_ChIP-Seq_DFB_Human1.53084963
38MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.45114323
39IRF1_19129219_ChIP-ChIP_H3396_Human1.44768216
40FOXA1_27270436_Chip-Seq_PROSTATE_Human1.42615152
41FOXA1_25329375_ChIP-Seq_VCAP_Human1.42615152
42FOXP3_21729870_ChIP-Seq_TREG_Human1.41382076
43RNF2_27304074_Chip-Seq_NSC_Mouse1.37822014
44CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.31471729
45TTF2_22483619_ChIP-Seq_HELA_Human1.28677749
46POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.28669893
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.28259432
48AR_20517297_ChIP-Seq_VCAP_Human1.26809264
49TP63_19390658_ChIP-ChIP_HaCaT_Human1.26380278
50MYC_19079543_ChIP-ChIP_MESCs_Mouse1.26075856
51ZFP57_27257070_Chip-Seq_ESCs_Mouse1.25996948
52TP53_22573176_ChIP-Seq_HFKS_Human1.21027885
53JARID2_20064375_ChIP-Seq_MESCs_Mouse1.20792935
54EZH2_27304074_Chip-Seq_ESCs_Mouse1.20688564
55CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.16405319
56AUTS2_25519132_ChIP-Seq_293T-REX_Human1.16129899
57EED_16625203_ChIP-ChIP_MESCs_Mouse1.14368008
58SOX2_16153702_ChIP-ChIP_HESCs_Human1.13140779
59CREB1_15753290_ChIP-ChIP_HEK293T_Human1.12205847
60NANOG_19829295_ChIP-Seq_ESCs_Human1.12159403
61SOX2_19829295_ChIP-Seq_ESCs_Human1.12159403
62NCOR_22424771_ChIP-Seq_293T_Human1.11386298
63KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10895270
64GATA1_22025678_ChIP-Seq_K562_Human1.10537719
65SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07884990
66UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05171575
67FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.05146119
68TDRD3_21172665_ChIP-Seq_MCF-7_Human1.04842070
69NFE2_27457419_Chip-Seq_LIVER_Mouse1.04280123
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02908476
71PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02390134
72MYC_18358816_ChIP-ChIP_MESCs_Mouse0.99775767
73FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.98789483
74PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.98387925
75ER_23166858_ChIP-Seq_MCF-7_Human0.97116995
76ETV2_25802403_ChIP-Seq_MESCs_Mouse0.96835854
77NOTCH1_21737748_ChIP-Seq_TLL_Human0.96339211
78CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.95968513
79NANOG_20526341_ChIP-Seq_ESCs_Human0.93792645
80EZH2_27294783_Chip-Seq_NPCs_Mouse0.92865039
81CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.92435206
82MYC_19030024_ChIP-ChIP_MESCs_Mouse0.92362985
83SRF_21415370_ChIP-Seq_HL-1_Mouse0.92162614
84SMAD3_21741376_ChIP-Seq_EPCs_Human0.91423366
85CBP_20019798_ChIP-Seq_JUKART_Human0.91232814
86IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.91232814
87TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91135306
88POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.91135306
89AR_25329375_ChIP-Seq_VCAP_Human0.90652322
90BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.90591266
91FOXH1_21741376_ChIP-Seq_EPCs_Human0.90154294
92MYC_19829295_ChIP-Seq_ESCs_Human0.90145996
93SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.89666305
94RBPJ_21746931_ChIP-Seq_IB4_Human0.88102478
95NANOG_16153702_ChIP-ChIP_HESCs_Human0.88055528
96NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87260860
97BCAT_22108803_ChIP-Seq_LS180_Human0.87121753
98PCGF2_27294783_Chip-Seq_NPCs_Mouse0.86469813
99EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.86353019
100GATA3_21878914_ChIP-Seq_MCF-7_Human0.86118789

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.73216240
2MP0006292_abnormal_olfactory_placode4.38741023
3MP0002837_dystrophic_cardiac_calcinosis3.19910536
4MP0008789_abnormal_olfactory_epithelium3.15497906
5MP0001293_anophthalmia2.58731698
6MP0005499_abnormal_olfactory_system2.45754606
7MP0005394_taste/olfaction_phenotype2.45754606
8MP0005646_abnormal_pituitary_gland2.38079187
9MP0006072_abnormal_retinal_apoptosis2.37140216
10MP0003121_genomic_imprinting2.35534618
11MP0009697_abnormal_copulation2.30307553
12MP0008877_abnormal_DNA_methylation2.28287818
13MP0001873_stomach_inflammation2.09972921
14MP0003567_abnormal_fetal_cardiomyocyte2.05182258
15MP0003787_abnormal_imprinting1.86280140
16MP0002102_abnormal_ear_morphology1.74913877
17MP0004142_abnormal_muscle_tone1.68725950
18MP0003880_abnormal_central_pattern1.67778057
19MP0008058_abnormal_DNA_repair1.61415998
20MP0002160_abnormal_reproductive_system1.53256041
21MP0000631_abnormal_neuroendocrine_gland1.53198194
22MP0005084_abnormal_gallbladder_morpholo1.49025518
23MP0003123_paternal_imprinting1.48968623
24MP0002277_abnormal_respiratory_mucosa1.44913774
25MP0006276_abnormal_autonomic_nervous1.44324052
26MP0002163_abnormal_gland_morphology1.44100574
27MP0005379_endocrine/exocrine_gland_phen1.39843756
28MP0008995_early_reproductive_senescence1.39091622
29MP0003786_premature_aging1.35502978
30MP0003122_maternal_imprinting1.35472662
31MP0010386_abnormal_urinary_bladder1.34440316
32MP0002653_abnormal_ependyma_morphology1.33106709
33MP0004510_myositis1.30954426
34MP0003283_abnormal_digestive_organ1.30676752
35MP0002138_abnormal_hepatobiliary_system1.25783526
36MP0005551_abnormal_eye_electrophysiolog1.25002164
37MP0005645_abnormal_hypothalamus_physiol1.22281998
38MP0001727_abnormal_embryo_implantation1.22073457
39MP0003693_abnormal_embryo_hatching1.16913878
40MP0003011_delayed_dark_adaptation1.15483257
41MP0001188_hyperpigmentation1.15248171
42MP0005389_reproductive_system_phenotype1.15126061
43MP0003937_abnormal_limbs/digits/tail_de1.13338577
44MP0008872_abnormal_physiological_respon1.12469501
45MP0003195_calcinosis1.12312238
46MP0005377_hearing/vestibular/ear_phenot1.11754197
47MP0003878_abnormal_ear_physiology1.11754197
48MP0000049_abnormal_middle_ear1.11018930
49MP0002938_white_spotting1.07943572
50MP0002234_abnormal_pharynx_morphology1.07412338
51MP0002233_abnormal_nose_morphology1.06958500
52MP0005174_abnormal_tail_pigmentation1.06445760
53MP0010094_abnormal_chromosome_stability1.05980742
54MP0009333_abnormal_splenocyte_physiolog1.05948071
55MP0003879_abnormal_hair_cell1.05179976
56MP0002272_abnormal_nervous_system1.04773058
57MP0003718_maternal_effect1.03583688
58MP0010030_abnormal_orbit_morphology1.03523966
59MP0001529_abnormal_vocalization1.03179765
60MP0003136_yellow_coat_color0.97348228
61MP0006082_CNS_inflammation0.97061673
62MP0001986_abnormal_taste_sensitivity0.96571993
63MP0003646_muscle_fatigue0.94116252
64MP0001286_abnormal_eye_development0.93833375
65MP0001835_abnormal_antigen_presentation0.93322539
66MP0005195_abnormal_posterior_eye0.92983730
67MP0005075_abnormal_melanosome_morpholog0.90785930
68MP0002876_abnormal_thyroid_physiology0.90523524
69MP0001764_abnormal_homeostasis0.90282251
70MP0003186_abnormal_redox_activity0.89063147
71MP0005253_abnormal_eye_physiology0.88555224
72MP0008875_abnormal_xenobiotic_pharmacok0.87164650
73MP0000026_abnormal_inner_ear0.87159467
74MP0004885_abnormal_endolymph0.86084926
75MP0001905_abnormal_dopamine_level0.84980238
76MP0001663_abnormal_digestive_system0.84826934
77MP0004145_abnormal_muscle_electrophysio0.83934568
78MP0003890_abnormal_embryonic-extraembry0.83358065
79MP0000778_abnormal_nervous_system0.81917360
80MP0004957_abnormal_blastocyst_morpholog0.81145625
81MP0001485_abnormal_pinna_reflex0.79755381
82MP0004084_abnormal_cardiac_muscle0.78646418
83MP0002132_abnormal_respiratory_system0.76018432
84MP0005671_abnormal_response_to0.74045583
85MP0002210_abnormal_sex_determination0.73540511
86MP0003938_abnormal_ear_development0.72936344
87MP0002095_abnormal_skin_pigmentation0.71704691
88MP0001324_abnormal_eye_pigmentation0.71387064
89MP0000685_abnormal_immune_system0.69756494
90MP0002752_abnormal_somatic_nervous0.68852615
91MP0003763_abnormal_thymus_physiology0.67267882
92MP0009250_abnormal_appendicular_skeleto0.66892191
93MP0004742_abnormal_vestibular_system0.66211659
94MP0005391_vision/eye_phenotype0.66176657
95MP0001346_abnormal_lacrimal_gland0.65914750
96MP0003315_abnormal_perineum_morphology0.65721172
97MP0002736_abnormal_nociception_after0.65546164
98MP0000653_abnormal_sex_gland0.64247521
99MP0001145_abnormal_male_reproductive0.63100825
100MP0009745_abnormal_behavioral_response0.62843399

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of macular pigmentation (HP:0008002)4.14452908
2Abnormality of cells of the erythroid lineage (HP:0012130)4.05833722
3Aplasia/Hypoplasia of the sacrum (HP:0008517)4.00322179
4Abnormal ciliary motility (HP:0012262)3.81398669
5Increased hepatocellular lipid droplets (HP:0006565)3.75537114
6Abnormal respiratory motile cilium morphology (HP:0005938)3.70593946
7Abnormal respiratory epithelium morphology (HP:0012253)3.70593946
8Macrocytic anemia (HP:0001972)3.67830891
9Abnormal number of erythroid precursors (HP:0012131)3.63431299
10Chronic sinusitis (HP:0011109)3.55449234
11Volvulus (HP:0002580)3.42254657
12Acute necrotizing encephalopathy (HP:0006965)3.39458706
13Increased intramyocellular lipid droplets (HP:0012240)3.36543734
14Abnormal pupillary function (HP:0007686)3.36215157
15Reticulocytopenia (HP:0001896)3.29414217
16Nephronophthisis (HP:0000090)3.19679265
17Lipid accumulation in hepatocytes (HP:0006561)3.15165650
18Hyperglycinemia (HP:0002154)3.12931237
19Stomatitis (HP:0010280)3.09706447
20Abnormal respiratory motile cilium physiology (HP:0012261)3.08185197
21Pancreatic cysts (HP:0001737)3.06353821
22Congenital, generalized hypertrichosis (HP:0004540)3.04100289
23Acute encephalopathy (HP:0006846)3.01108979
24Maternal diabetes (HP:0009800)3.00793490
25Molar tooth sign on MRI (HP:0002419)2.98339028
26Abnormality of midbrain morphology (HP:0002418)2.98339028
27Constricted visual fields (HP:0001133)2.88548365
28Colon cancer (HP:0003003)2.80014089
29Renal Fanconi syndrome (HP:0001994)2.79292785
30Mitochondrial inheritance (HP:0001427)2.77764500
31Exertional dyspnea (HP:0002875)2.77087571
32Stenosis of the external auditory canal (HP:0000402)2.71466888
33Cone-rod dystrophy (HP:0000548)2.70571232
34Progressive macrocephaly (HP:0004481)2.69213940
35Abnormal mitochondria in muscle tissue (HP:0008316)2.67611664
36Increased muscle lipid content (HP:0009058)2.66786445
37Pallor (HP:0000980)2.59812021
38Septo-optic dysplasia (HP:0100842)2.58981900
39Small hand (HP:0200055)2.56941609
40Decreased electroretinogram (ERG) amplitude (HP:0000654)2.56631201
41Rhinitis (HP:0012384)2.53364327
42Tubular atrophy (HP:0000092)2.51867628
43Abnormality of the renal medulla (HP:0100957)2.47648200
44Abnormality of the labia minora (HP:0012880)2.45804633
45Increased CSF lactate (HP:0002490)2.42838934
46Abnormality of the phalanges of the 2nd finger (HP:0009541)2.41675936
47Abnormality of renal resorption (HP:0011038)2.38291452
483-Methylglutaconic aciduria (HP:0003535)2.32262040
49Congenital stationary night blindness (HP:0007642)2.32109688
50Asplenia (HP:0001746)2.31314789
51Abnormality of the phalanges of the 5th finger (HP:0004213)2.30255579
52Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.29540174
53Aplasia/Hypoplasia of the spleen (HP:0010451)2.28986496
54Methylmalonic acidemia (HP:0002912)2.28508044
55True hermaphroditism (HP:0010459)2.27798716
56Pancreatic fibrosis (HP:0100732)2.27683464
57Cerebral edema (HP:0002181)2.26926573
58Aplastic anemia (HP:0001915)2.26786877
59Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.24091468
60Decreased activity of mitochondrial respiratory chain (HP:0008972)2.24091468
61Abolished electroretinogram (ERG) (HP:0000550)2.16653743
62Attenuation of retinal blood vessels (HP:0007843)2.15050148
63Optic disc pallor (HP:0000543)2.14688242
64Decreased central vision (HP:0007663)2.14414557
65Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.10370087
66Medial flaring of the eyebrow (HP:0010747)2.10023158
67Anophthalmia (HP:0000528)2.09936846
68Metaphyseal cupping (HP:0003021)2.08236693
69Glycosuria (HP:0003076)2.07974019
70Abnormality of urine glucose concentration (HP:0011016)2.07974019
71Abnormal rod and cone electroretinograms (HP:0008323)2.03996305
72Hyperphosphaturia (HP:0003109)2.03171528
73Concave nail (HP:0001598)2.01972035
74Triphalangeal thumb (HP:0001199)2.01382933
75Confusion (HP:0001289)1.99216939
76Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.92766521
77Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.91952661
78Abnormality of the renal cortex (HP:0011035)1.91489309
79Abnormality of glycine metabolism (HP:0010895)1.89940443
80Abnormality of serine family amino acid metabolism (HP:0010894)1.89940443
81Striae distensae (HP:0001065)1.89853053
82Abnormality of the middle phalanges of the toes (HP:0010183)1.89710972
83Aplasia/hypoplasia of the uterus (HP:0008684)1.87803365
84Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.87625098
85Pendular nystagmus (HP:0012043)1.86864510
86Exercise intolerance (HP:0003546)1.85461387
87Absent rod-and cone-mediated responses on ERG (HP:0007688)1.82997051
88Abnormality of serum amino acid levels (HP:0003112)1.82126081
89Oligodontia (HP:0000677)1.81259771
90Anencephaly (HP:0002323)1.79076329
91Increased serum lactate (HP:0002151)1.77467174
92Dynein arm defect of respiratory motile cilia (HP:0012255)1.77456041
93Absent/shortened dynein arms (HP:0200106)1.77456041
94Cupped ribs (HP:0000887)1.76112982
95Palpitations (HP:0001962)1.74255344
96Bronchiectasis (HP:0002110)1.74103106
97Hyperglycinuria (HP:0003108)1.73313163
98Dyschromatopsia (HP:0007641)1.73174237
99Lethargy (HP:0001254)1.72523592
100Respiratory difficulties (HP:0002880)1.71967421

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK22.87657757
2EIF2AK12.81181516
3KIT2.76808162
4CDK192.71143423
5NUAK12.36621542
6TAOK32.30048717
7MAP4K22.29389502
8CDC72.27098514
9STK162.11092356
10TAF12.08640132
11TEC2.07054944
12TNIK2.05041896
13DYRK21.95722885
14WNK31.85545746
15NLK1.80986846
16MKNK11.80128101
17MKNK21.78825341
18ZAK1.78516080
19EIF2AK31.75951019
20PLK41.75630211
21GRK11.71779017
22TIE11.70507865
23PASK1.68199137
24BCKDK1.55194481
25VRK11.54889487
26MAP2K21.53915715
27ADRBK21.53195755
28BUB11.52757554
29MST41.37135010
30NEK91.32385639
31PLK31.28304928
32CDK31.26160178
33MAP3K41.25235057
34FRK1.24135302
35STK38L1.19999152
36CSNK1G11.10118389
37DYRK1A1.07141889
38BMPR1B1.06781537
39IKBKB1.01267646
40TNK21.01101053
41FES1.00147471
42TXK0.94209900
43PBK0.93543391
44INSRR0.92079970
45PLK20.87291103
46EIF2AK20.85362650
47CSNK1G20.82133225
48PINK10.80910901
49RPS6KB20.78915306
50TGFBR10.78001549
51DAPK10.75477531
52WNK40.75370269
53TLK10.74962903
54TRIM280.74412994
55EPHB20.68606662
56BTK0.68312956
57NEK10.66660080
58MAPK130.66641083
59RPS6KA40.66146970
60DAPK30.64749793
61GRK70.63477730
62IKBKE0.62371622
63EPHA40.61788375
64MAP2K10.60241920
65CSNK2A10.59026366
66ADRBK10.58107240
67GRK50.57778240
68PHKG20.54119124
69PHKG10.54119124
70PRKCQ0.53783064
71PLK10.53566138
72STK390.52935691
73PRKACA0.51825737
74CSNK1G30.51615077
75PRKCG0.50315569
76AURKB0.49973831
77BMPR20.49887724
78RPS6KA60.49709776
79PRKCE0.49255789
80CSNK2A20.48462599
81SYK0.47706081
82SGK2230.45367771
83SGK4940.45367771
84BCR0.45319498
85NTRK20.43250782
86OBSCN0.43223630
87PIK3CA0.43211946
88LATS10.42529666
89ABL20.40475205
90WEE10.38988120
91CSNK1A10.38983741
92FGFR20.38944067
93OXSR10.37993941
94SRPK10.37872233
95CAMK10.36793526
96FLT30.36244254
97CAMK2A0.36227767
98MAP3K120.36016267
99CSNK1D0.35706331
100PRKCA0.34148149

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.13456886
2Oxidative phosphorylation_Homo sapiens_hsa001903.36882254
3Asthma_Homo sapiens_hsa053103.29216385
4Parkinsons disease_Homo sapiens_hsa050122.85333228
5Proteasome_Homo sapiens_hsa030502.78098434
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.35543179
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.19631476
8Allograft rejection_Homo sapiens_hsa053302.19380592
9Autoimmune thyroid disease_Homo sapiens_hsa053202.07210173
10Mismatch repair_Homo sapiens_hsa034302.03327820
11Protein export_Homo sapiens_hsa030602.02914874
12Homologous recombination_Homo sapiens_hsa034401.99151350
13Graft-versus-host disease_Homo sapiens_hsa053321.96196958
14Phototransduction_Homo sapiens_hsa047441.88879671
15Type I diabetes mellitus_Homo sapiens_hsa049401.87670147
16RNA polymerase_Homo sapiens_hsa030201.86265068
17Huntingtons disease_Homo sapiens_hsa050161.82822107
18Alzheimers disease_Homo sapiens_hsa050101.81723322
19DNA replication_Homo sapiens_hsa030301.70457486
20Fanconi anemia pathway_Homo sapiens_hsa034601.60379282
21Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.58218830
22RNA degradation_Homo sapiens_hsa030181.50108931
23Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.49473198
24Cardiac muscle contraction_Homo sapiens_hsa042601.45207454
25Linoleic acid metabolism_Homo sapiens_hsa005911.38724752
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.36657636
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.36593220
28Propanoate metabolism_Homo sapiens_hsa006401.30689774
29Nucleotide excision repair_Homo sapiens_hsa034201.30520059
30Basal transcription factors_Homo sapiens_hsa030221.28311669
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.27530062
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.23716692
33Antigen processing and presentation_Homo sapiens_hsa046121.14501066
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.11816924
35Primary immunodeficiency_Homo sapiens_hsa053401.10444860
36Retinol metabolism_Homo sapiens_hsa008301.09588838
37Arachidonic acid metabolism_Homo sapiens_hsa005901.08700686
38Nicotine addiction_Homo sapiens_hsa050331.08215070
39Pyrimidine metabolism_Homo sapiens_hsa002401.06285167
40Spliceosome_Homo sapiens_hsa030401.04807511
41One carbon pool by folate_Homo sapiens_hsa006701.03154962
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.03150431
43Non-homologous end-joining_Homo sapiens_hsa034501.02499524
44Pentose and glucuronate interconversions_Homo sapiens_hsa000401.00799281
45Base excision repair_Homo sapiens_hsa034100.95968493
46Chemical carcinogenesis_Homo sapiens_hsa052040.95274451
47Tryptophan metabolism_Homo sapiens_hsa003800.94129266
48Purine metabolism_Homo sapiens_hsa002300.94129129
49Cysteine and methionine metabolism_Homo sapiens_hsa002700.90959378
50Rheumatoid arthritis_Homo sapiens_hsa053230.90942167
51Steroid hormone biosynthesis_Homo sapiens_hsa001400.90422812
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.90024594
53Olfactory transduction_Homo sapiens_hsa047400.89479068
54Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.89217747
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.88544872
56RNA transport_Homo sapiens_hsa030130.87173627
57alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.86970997
58beta-Alanine metabolism_Homo sapiens_hsa004100.86040969
59Viral myocarditis_Homo sapiens_hsa054160.81941333
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.78414020
61Systemic lupus erythematosus_Homo sapiens_hsa053220.75824735
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75072203
63Selenocompound metabolism_Homo sapiens_hsa004500.74573942
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71063565
65Ether lipid metabolism_Homo sapiens_hsa005650.71008309
66Regulation of autophagy_Homo sapiens_hsa041400.69904594
67Basal cell carcinoma_Homo sapiens_hsa052170.66739813
68Staphylococcus aureus infection_Homo sapiens_hsa051500.66603041
69Butanoate metabolism_Homo sapiens_hsa006500.61812836
70Peroxisome_Homo sapiens_hsa041460.59243296
71Hedgehog signaling pathway_Homo sapiens_hsa043400.56872857
72Metabolic pathways_Homo sapiens_hsa011000.54485616
73Caffeine metabolism_Homo sapiens_hsa002320.54366823
74Glutathione metabolism_Homo sapiens_hsa004800.53219855
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48823309
76Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48411525
77Hematopoietic cell lineage_Homo sapiens_hsa046400.43809031
78Drug metabolism - other enzymes_Homo sapiens_hsa009830.43576466
79p53 signaling pathway_Homo sapiens_hsa041150.42765116
80Taste transduction_Homo sapiens_hsa047420.42261844
81Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.41238653
82Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40563871
83Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.39861501
84Serotonergic synapse_Homo sapiens_hsa047260.39681234
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39595896
86Ovarian steroidogenesis_Homo sapiens_hsa049130.39116399
87Nitrogen metabolism_Homo sapiens_hsa009100.38379675
88Sulfur metabolism_Homo sapiens_hsa009200.38046431
89Pyruvate metabolism_Homo sapiens_hsa006200.36170891
90Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.34720160
91Fat digestion and absorption_Homo sapiens_hsa049750.29377721
92Histidine metabolism_Homo sapiens_hsa003400.27645925
93Melanoma_Homo sapiens_hsa052180.27454680
94Starch and sucrose metabolism_Homo sapiens_hsa005000.24958813
95Insulin secretion_Homo sapiens_hsa049110.23709669
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.22513896
97Arginine and proline metabolism_Homo sapiens_hsa003300.21720403
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.21551231
99Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.21117435
100Morphine addiction_Homo sapiens_hsa050320.20967299

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