NAP1L3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is intronless and encodes a member of the nucleosome assembly protein (NAP) family. This gene is linked closely to a region of genes responsible for several X-linked mental retardation syndromes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)5.25716243
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.24651854
3neuron cell-cell adhesion (GO:0007158)5.22073115
4synaptic vesicle exocytosis (GO:0016079)5.21941276
5vocalization behavior (GO:0071625)4.89740438
6synaptic vesicle maturation (GO:0016188)4.75699207
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.71216536
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.64703818
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.61388406
10regulation of synaptic vesicle exocytosis (GO:2000300)4.52663651
11neuronal action potential propagation (GO:0019227)4.50150591
12protein localization to synapse (GO:0035418)4.44094244
13glutamate secretion (GO:0014047)4.37172279
14nucleobase catabolic process (GO:0046113)4.36889095
15regulation of glutamate receptor signaling pathway (GO:1900449)4.31187585
16locomotory exploration behavior (GO:0035641)4.29133028
17establishment of mitochondrion localization (GO:0051654)4.27772262
18ionotropic glutamate receptor signaling pathway (GO:0035235)4.25818228
19neurotransmitter secretion (GO:0007269)4.08890289
20layer formation in cerebral cortex (GO:0021819)4.06715558
21neuron recognition (GO:0008038)4.00603838
22glutamate receptor signaling pathway (GO:0007215)3.99062625
23regulation of synaptic vesicle transport (GO:1902803)3.92834694
24gamma-aminobutyric acid signaling pathway (GO:0007214)3.91181197
25regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.88694550
26exploration behavior (GO:0035640)3.84537305
27presynaptic membrane assembly (GO:0097105)3.84446929
28transmission of nerve impulse (GO:0019226)3.83791861
29synaptic transmission, glutamatergic (GO:0035249)3.80271681
30neuron-neuron synaptic transmission (GO:0007270)3.78553473
31dendritic spine morphogenesis (GO:0060997)3.73662981
32sodium ion export (GO:0071436)3.68229125
33regulation of neuronal synaptic plasticity (GO:0048168)3.67539015
34auditory behavior (GO:0031223)3.66684728
35presynaptic membrane organization (GO:0097090)3.65981642
36startle response (GO:0001964)3.65685593
37gamma-aminobutyric acid transport (GO:0015812)3.64742341
38regulation of long-term neuronal synaptic plasticity (GO:0048169)3.63076432
39neurotransmitter transport (GO:0006836)3.56197822
40positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.55428730
41postsynaptic membrane organization (GO:0001941)3.52354586
42regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.43881829
43negative regulation of synaptic transmission, GABAergic (GO:0032229)3.42421944
44regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.41780480
45axonal fasciculation (GO:0007413)3.41384417
46synapse assembly (GO:0007416)3.40896309
47regulation of excitatory postsynaptic membrane potential (GO:0060079)3.39452644
48neurofilament cytoskeleton organization (GO:0060052)3.38964808
49positive regulation of membrane potential (GO:0045838)3.37406411
50synaptic vesicle endocytosis (GO:0048488)3.36949302
51synaptic vesicle docking involved in exocytosis (GO:0016081)3.36181386
52positive regulation of synaptic transmission, GABAergic (GO:0032230)3.34546858
53response to auditory stimulus (GO:0010996)3.32757357
54amino acid import (GO:0043090)3.31804000
55long-term memory (GO:0007616)3.31705788
56regulation of vesicle fusion (GO:0031338)3.30744408
57mating behavior (GO:0007617)3.30624823
58positive regulation of dendritic spine morphogenesis (GO:0061003)3.30169965
59proline transport (GO:0015824)3.29056827
60regulation of synapse structural plasticity (GO:0051823)3.27250308
61neurotransmitter-gated ion channel clustering (GO:0072578)3.26776776
62regulation of postsynaptic membrane potential (GO:0060078)3.26750237
63regulation of neurotransmitter levels (GO:0001505)3.25609561
64membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.22654854
65innervation (GO:0060384)3.21362886
66regulation of voltage-gated calcium channel activity (GO:1901385)3.20302800
67glycosphingolipid biosynthetic process (GO:0006688)3.18792063
68positive regulation of synapse assembly (GO:0051965)3.16685361
69mechanosensory behavior (GO:0007638)3.16240203
70regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.15236865
71activation of protein kinase A activity (GO:0034199)3.15226997
72regulation of neurotransmitter secretion (GO:0046928)3.14867691
73neuromuscular process controlling posture (GO:0050884)3.14406839
74regulation of glutamate secretion (GO:0014048)3.12901676
75acidic amino acid transport (GO:0015800)3.11461859
76long-term synaptic potentiation (GO:0060291)3.11451898
77L-amino acid import (GO:0043092)3.10973877
78G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.10149588
79neuromuscular synaptic transmission (GO:0007274)3.10080192
80regulation of synaptic transmission, glutamatergic (GO:0051966)3.09898359
81positive regulation of dendritic spine development (GO:0060999)3.09808867
82establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.07699854
83mitochondrion transport along microtubule (GO:0047497)3.07699854
84neurotransmitter uptake (GO:0001504)3.07437827
85cell communication by electrical coupling (GO:0010644)3.03025314
86synapse organization (GO:0050808)3.02668933
87negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.02222661
88regulation of dendritic spine morphogenesis (GO:0061001)3.01955492
89regulation of synapse maturation (GO:0090128)3.01077547
90adult walking behavior (GO:0007628)3.00824991
91dendrite morphogenesis (GO:0048813)3.00098706
92central nervous system myelination (GO:0022010)3.00025195
93axon ensheathment in central nervous system (GO:0032291)3.00025195
94cellular potassium ion homeostasis (GO:0030007)2.99917635
95cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.98599018
96membrane hyperpolarization (GO:0060081)2.96773849
97negative regulation of neurotransmitter transport (GO:0051589)2.96439815
98regulation of neurotransmitter transport (GO:0051588)2.95870145
99positive regulation of synapse maturation (GO:0090129)2.94848608
100membrane depolarization (GO:0051899)2.94121651
101cell migration in hindbrain (GO:0021535)2.93708293
102regulation of synaptic plasticity (GO:0048167)2.93574947
103negative regulation of microtubule polymerization (GO:0031115)2.93312530
104synaptic transmission (GO:0007268)2.92130554
105response to histamine (GO:0034776)2.91471988
106synaptic vesicle transport (GO:0048489)2.90835022
107establishment of synaptic vesicle localization (GO:0097480)2.90835022
108regulation of synaptic transmission, GABAergic (GO:0032228)2.89777126
109regulation of dendritic spine development (GO:0060998)2.89232469
110cerebellar Purkinje cell differentiation (GO:0021702)2.88396995
111establishment of vesicle localization (GO:0051650)2.88196635
112membrane depolarization during action potential (GO:0086010)2.85434386
113positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.84652354
114learning (GO:0007612)2.84571825
115neuronal ion channel clustering (GO:0045161)2.83793963
116cerebellar granule cell differentiation (GO:0021707)2.82422623
117C4-dicarboxylate transport (GO:0015740)2.80486260
118dendritic spine organization (GO:0097061)2.79845558
119dendrite development (GO:0016358)2.79266614
120behavioral defense response (GO:0002209)2.77164798
121behavioral fear response (GO:0001662)2.77164798
122prepulse inhibition (GO:0060134)2.76681177
123behavioral response to cocaine (GO:0048148)2.76013097
124long-chain fatty acid biosynthetic process (GO:0042759)2.75634877

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.64189486
2GBX2_23144817_ChIP-Seq_PC3_Human3.90031330
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.15300878
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.12879072
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.03021578
6REST_21632747_ChIP-Seq_MESCs_Mouse2.62613606
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.62563139
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.60447457
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.59213276
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.59213276
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.57154515
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.54844129
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.49099582
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.44714175
15TAF15_26573619_Chip-Seq_HEK293_Human2.44559178
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.41741579
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.33519166
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.27014980
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.21786112
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.21612669
21CTBP2_25329375_ChIP-Seq_LNCAP_Human2.17496445
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.14571460
23REST_18959480_ChIP-ChIP_MESCs_Mouse2.07521540
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.04778525
25DROSHA_22980978_ChIP-Seq_HELA_Human2.01751815
26ZFP57_27257070_Chip-Seq_ESCs_Mouse1.98598656
27RARB_27405468_Chip-Seq_BRAIN_Mouse1.96443394
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.95330181
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.93018248
30AR_21572438_ChIP-Seq_LNCaP_Human1.86176577
31* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.78712960
32IKZF1_21737484_ChIP-ChIP_HCT116_Human1.78248775
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.75933815
34CBX2_27304074_Chip-Seq_ESCs_Mouse1.74085647
35SMAD4_21799915_ChIP-Seq_A2780_Human1.73079654
36P300_19829295_ChIP-Seq_ESCs_Human1.72991848
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.69400958
38IGF1R_20145208_ChIP-Seq_DFB_Human1.67604726
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.63533505
40HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.62754377
41RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.62053279
42SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.58515344
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.56587216
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.55606311
45OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54828424
46PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.54284165
47FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.52081807
48RNF2_27304074_Chip-Seq_NSC_Mouse1.51689335
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.48071444
50RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.47432523
51ZNF274_21170338_ChIP-Seq_K562_Hela1.45371944
52NR3C1_23031785_ChIP-Seq_PC12_Mouse1.43399561
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39708680
54CDX2_19796622_ChIP-Seq_MESCs_Mouse1.38980958
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38566509
56* FUS_26573619_Chip-Seq_HEK293_Human1.36677124
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.35271919
58SOX2_21211035_ChIP-Seq_LN229_Gbm1.34102508
59GATA1_26923725_Chip-Seq_HPCs_Mouse1.33373024
60AR_25329375_ChIP-Seq_VCAP_Human1.32712762
61VDR_22108803_ChIP-Seq_LS180_Human1.30247845
62ERG_21242973_ChIP-ChIP_JURKAT_Human1.29155199
63GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27257100
64STAT3_23295773_ChIP-Seq_U87_Human1.27169396
65ER_23166858_ChIP-Seq_MCF-7_Human1.26648604
66RING1B_27294783_Chip-Seq_ESCs_Mouse1.23440014
67RBPJ_22232070_ChIP-Seq_NCS_Mouse1.20738542
68TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19253710
69UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19080352
70P53_22127205_ChIP-Seq_FIBROBLAST_Human1.17076845
71AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13516881
72TCF4_23295773_ChIP-Seq_U87_Human1.12653395
73RUNX2_22187159_ChIP-Seq_PCA_Human1.09481035
74CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.09466024
75JUN_21703547_ChIP-Seq_K562_Human1.09319926
76MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08957054
77SALL1_21062744_ChIP-ChIP_HESCs_Human1.08373145
78TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08159403
79MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08018087
80POU5F1_16153702_ChIP-ChIP_HESCs_Human1.06331183
81PRDM14_20953172_ChIP-Seq_ESCs_Human1.06150835
82AR_19668381_ChIP-Seq_PC3_Human1.05621923
83NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04232900
84EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02942433
85RING1B_27294783_Chip-Seq_NPCs_Mouse1.02602755
86RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.01612404
87ARNT_22903824_ChIP-Seq_MCF-7_Human1.01597361
88MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.01059024
89SOX9_26525672_Chip-Seq_HEART_Mouse1.00985984
90KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99226381
91CBP_20019798_ChIP-Seq_JUKART_Human0.98107733
92IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98107733
93SMAD_19615063_ChIP-ChIP_OVARY_Human0.98006796
94FLI1_27457419_Chip-Seq_LIVER_Mouse0.97825352
95TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97248458
96CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97170633
97TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95986891
98POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95986891
99AHR_22903824_ChIP-Seq_MCF-7_Human0.95577085
100TAL1_26923725_Chip-Seq_HPCs_Mouse0.94831918
101NANOG_18555785_Chip-Seq_ESCs_Mouse0.94750735
102SMAD3_21741376_ChIP-Seq_ESCs_Human0.94487417
103NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.94376705
104YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94354491
105WT1_25993318_ChIP-Seq_PODOCYTE_Human0.94266506
106TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.93785239
107ZNF217_24962896_ChIP-Seq_MCF-7_Human0.91468771
108KDM2B_26808549_Chip-Seq_REH_Human0.91042508
109ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.87909150
110BCAT_22108803_ChIP-Seq_LS180_Human0.87191753
111MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.87037491
112LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86757620
113CMYC_18555785_Chip-Seq_ESCs_Mouse0.83906695
114DNAJC2_21179169_ChIP-ChIP_NT2_Human0.83557660
115FLI1_21867929_ChIP-Seq_TH2_Mouse0.82632597
116* EWS_26573619_Chip-Seq_HEK293_Human0.82436811

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.30756050
2MP0004859_abnormal_synaptic_plasticity5.06662351
3MP0003635_abnormal_synaptic_transmissio3.79800538
4MP0004270_analgesia3.58263394
5MP0009745_abnormal_behavioral_response3.22560286
6MP0001968_abnormal_touch/_nociception3.22329061
7MP0002064_seizures3.03981116
8MP0002063_abnormal_learning/memory/cond3.00634046
9MP0005423_abnormal_somatic_nervous2.99792873
10MP0009046_muscle_twitch2.95134351
11MP0002734_abnormal_mechanical_nocicepti2.76970476
12MP0002272_abnormal_nervous_system2.74401061
13MP0002572_abnormal_emotion/affect_behav2.74050620
14MP0002736_abnormal_nociception_after2.69334492
15MP0001486_abnormal_startle_reflex2.58993590
16MP0002735_abnormal_chemical_nociception2.53353807
17MP0006276_abnormal_autonomic_nervous2.53283302
18MP0002733_abnormal_thermal_nociception2.22286778
19MP0001529_abnormal_vocalization2.18350357
20MP0001501_abnormal_sleep_pattern2.17400036
21MP0001440_abnormal_grooming_behavior2.15004759
22MP0000778_abnormal_nervous_system2.13352024
23MP0002067_abnormal_sensory_capabilities2.11196447
24MP0001970_abnormal_pain_threshold2.09740087
25MP0002822_catalepsy2.02607241
26MP0002184_abnormal_innervation2.00040538
27MP0001905_abnormal_dopamine_level1.95291993
28MP0004924_abnormal_behavior1.86999979
29MP0005386_behavior/neurological_phenoty1.86999979
30MP0003329_amyloid_beta_deposits1.86275713
31MP0004142_abnormal_muscle_tone1.74927783
32MP0008877_abnormal_DNA_methylation1.71283457
33MP0002557_abnormal_social/conspecific_i1.71032245
34MP0008569_lethality_at_weaning1.69298406
35MP0000955_abnormal_spinal_cord1.64768964
36MP0005645_abnormal_hypothalamus_physiol1.64143771
37MP0003122_maternal_imprinting1.60503703
38MP0004811_abnormal_neuron_physiology1.57277209
39MP0001984_abnormal_olfaction1.52251274
40MP0004885_abnormal_endolymph1.48302720
41MP0002882_abnormal_neuron_morphology1.48072360
42MP0001188_hyperpigmentation1.47888593
43MP0002066_abnormal_motor_capabilities/c1.46342360
44MP0005646_abnormal_pituitary_gland1.46283572
45MP0001502_abnormal_circadian_rhythm1.45047578
46MP0003787_abnormal_imprinting1.35203360
47MP0000920_abnormal_myelination1.33811355
48MP0002909_abnormal_adrenal_gland1.33194697
49MP0004742_abnormal_vestibular_system1.32711896
50MP0009780_abnormal_chondrocyte_physiolo1.29918464
51MP0005551_abnormal_eye_electrophysiolog1.28792759
52MP0003879_abnormal_hair_cell1.18794008
53MP0004858_abnormal_nervous_system1.18469009
54MP0002229_neurodegeneration1.16495275
55MP0003633_abnormal_nervous_system1.13881718
56MP0005409_darkened_coat_color1.10799352
57MP0002152_abnormal_brain_morphology1.09424268
58MP0010386_abnormal_urinary_bladder1.08911132
59MP0000751_myopathy1.07819613
60MP0003634_abnormal_glial_cell1.05820385
61MP0003631_nervous_system_phenotype1.05800733
62MP0002752_abnormal_somatic_nervous0.99734163
63MP0001963_abnormal_hearing_physiology0.98564226
64MP0006072_abnormal_retinal_apoptosis0.96912600
65MP0000631_abnormal_neuroendocrine_gland0.95956312
66MP0004133_heterotaxia0.95665104
67MP0003632_abnormal_nervous_system0.91165329
68MP0004145_abnormal_muscle_electrophysio0.87599487
69MP0003690_abnormal_glial_cell0.87236479
70MP0002069_abnormal_eating/drinking_beha0.86941292
71MP0005187_abnormal_penis_morphology0.83420753
72MP0001986_abnormal_taste_sensitivity0.83381394
73MP0004147_increased_porphyrin_level0.82828307
74MP0005535_abnormal_body_temperature0.82252104
75MP0002653_abnormal_ependyma_morphology0.81090889
76MP0002090_abnormal_vision0.80545941
77MP0003119_abnormal_digestive_system0.79508586
78MP0002638_abnormal_pupillary_reflex0.79007059
79MP0005394_taste/olfaction_phenotype0.78784590
80MP0005499_abnormal_olfactory_system0.78784590
81MP0003011_delayed_dark_adaptation0.77901232
82MP0005084_abnormal_gallbladder_morpholo0.77328285
83MP0001485_abnormal_pinna_reflex0.76986735
84MP0004085_abnormal_heartbeat0.75442932
85MP0003123_paternal_imprinting0.75416044
86MP0000604_amyloidosis0.75078908
87MP0008872_abnormal_physiological_respon0.73923305
88MP0002837_dystrophic_cardiac_calcinosis0.73868466
89MP0008874_decreased_physiological_sensi0.73063042
90MP0003121_genomic_imprinting0.71970319
91MP0001177_atelectasis0.71399969
92MP0002876_abnormal_thyroid_physiology0.71319359
93MP0001664_abnormal_digestion0.69622163
94MP0008789_abnormal_olfactory_epithelium0.68190735
95MP0003283_abnormal_digestive_organ0.67866505
96MP0000026_abnormal_inner_ear0.67123924
97MP0003938_abnormal_ear_development0.66506430
98MP0002102_abnormal_ear_morphology0.65797920
99MP0003137_abnormal_impulse_conducting0.63118697
100MP0006292_abnormal_olfactory_placode0.61270358
101MP0000013_abnormal_adipose_tissue0.60811694
102MP0010769_abnormal_survival0.60316161
103MP0001943_abnormal_respiration0.59735399
104MP0000049_abnormal_middle_ear0.59166264
105MP0003861_abnormal_nervous_system0.58883089
106MP0004484_altered_response_of0.58846395
107MP0002751_abnormal_autonomic_nervous0.58473115
108MP0010768_mortality/aging0.57990621
109MP0005253_abnormal_eye_physiology0.57228755
110MP0004215_abnormal_myocardial_fiber0.56493768
111MP0001299_abnormal_eye_distance/0.54798647
112MP0005623_abnormal_meninges_morphology0.54496962
113MP0002234_abnormal_pharynx_morphology0.52535970
114MP0002082_postnatal_lethality0.52334040
115MP0010770_preweaning_lethality0.52334040

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.52598736
2Myokymia (HP:0002411)5.92488780
3Focal seizures (HP:0007359)4.95834788
4Atonic seizures (HP:0010819)4.88537171
5Visual hallucinations (HP:0002367)4.49785151
6Epileptic encephalopathy (HP:0200134)4.47372333
7Progressive cerebellar ataxia (HP:0002073)4.32186958
8Febrile seizures (HP:0002373)4.24371221
9Absence seizures (HP:0002121)3.99661498
10Supranuclear gaze palsy (HP:0000605)3.94308839
11Dialeptic seizures (HP:0011146)3.66943159
12Generalized tonic-clonic seizures (HP:0002069)3.53099089
13Progressive inability to walk (HP:0002505)3.46451563
14Ankle clonus (HP:0011448)3.42218579
15Broad-based gait (HP:0002136)3.39799939
16Abnormality of the corticospinal tract (HP:0002492)3.32335649
17Action tremor (HP:0002345)3.32178798
18Spastic gait (HP:0002064)3.25770111
19Neurofibrillary tangles (HP:0002185)3.24814771
20Limb dystonia (HP:0002451)3.23948074
21Mutism (HP:0002300)3.11843611
22Dysmetria (HP:0001310)3.09341733
23Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.98439614
24Degeneration of the lateral corticospinal tracts (HP:0002314)2.98439614
25Cerebral inclusion bodies (HP:0100314)2.93858654
26Scanning speech (HP:0002168)2.90054581
27Anxiety (HP:0000739)2.88830797
28Hyperventilation (HP:0002883)2.86324628
29Abnormality of the labia minora (HP:0012880)2.85531300
30Truncal ataxia (HP:0002078)2.83192642
31Pheochromocytoma (HP:0002666)2.81629065
32Impaired vibration sensation in the lower limbs (HP:0002166)2.80506848
33Abnormality of the lower motor neuron (HP:0002366)2.76759717
34Insidious onset (HP:0003587)2.76353478
35Termporal pattern (HP:0011008)2.76353478
36Abnormal eating behavior (HP:0100738)2.75146527
37Cerebral hypomyelination (HP:0006808)2.74612748
38Drooling (HP:0002307)2.73977701
39Excessive salivation (HP:0003781)2.73977701
40Urinary urgency (HP:0000012)2.73552948
41Abnormal hair whorl (HP:0010721)2.72096745
42Depression (HP:0000716)2.69064694
43Gaze-evoked nystagmus (HP:0000640)2.69049571
44Urinary bladder sphincter dysfunction (HP:0002839)2.67833771
45Polyphagia (HP:0002591)2.64907998
46Amblyopia (HP:0000646)2.59970965
47Gait imbalance (HP:0002141)2.59057419
48Dysdiadochokinesis (HP:0002075)2.56959366
49Spastic tetraplegia (HP:0002510)2.53108000
50Neuroendocrine neoplasm (HP:0100634)2.50689557
51Poor eye contact (HP:0000817)2.49326866
52Cortical dysplasia (HP:0002539)2.45675787
53Split foot (HP:0001839)2.43511067
54Atrophy/Degeneration involving motor neurons (HP:0007373)2.41069156
55Hemiparesis (HP:0001269)2.40206589
56Inability to walk (HP:0002540)2.38785933
57Epileptiform EEG discharges (HP:0011182)2.37975254
58Status epilepticus (HP:0002133)2.36551352
59Sleep apnea (HP:0010535)2.35154563
60Akinesia (HP:0002304)2.35102005
61Abnormality of binocular vision (HP:0011514)2.34375368
62Diplopia (HP:0000651)2.34375368
63Papilledema (HP:0001085)2.33993752
64EEG with generalized epileptiform discharges (HP:0011198)2.33612777
65Lower limb muscle weakness (HP:0007340)2.31325673
66Intention tremor (HP:0002080)2.27651641
67Fetal akinesia sequence (HP:0001989)2.25222159
68Postural instability (HP:0002172)2.25021053
69Genetic anticipation (HP:0003743)2.24382115
70Impaired social interactions (HP:0000735)2.24042084
71Abnormal social behavior (HP:0012433)2.24042084
72Agitation (HP:0000713)2.23035034
73Lissencephaly (HP:0001339)2.22036169
74Ulnar claw (HP:0001178)2.21160755
75Poor suck (HP:0002033)2.19859217
76Retinal dysplasia (HP:0007973)2.19559028
77Hypsarrhythmia (HP:0002521)2.17789488
78Absent speech (HP:0001344)2.16235913
79Specific learning disability (HP:0001328)2.14470997
80Torticollis (HP:0000473)2.13767915
81Failure to thrive in infancy (HP:0001531)2.12750423
82Congenital primary aphakia (HP:0007707)2.09148735
83Medial flaring of the eyebrow (HP:0010747)2.08017212
84Blue irides (HP:0000635)2.06507199
85Bradykinesia (HP:0002067)2.06005627
86Neuronal loss in central nervous system (HP:0002529)2.04483227
87Genital tract atresia (HP:0001827)2.04442815
88Tetraplegia (HP:0002445)2.04311662
89Peripheral hypomyelination (HP:0007182)2.03752280
90Morphological abnormality of the pyramidal tract (HP:0002062)2.03050570
91Vaginal atresia (HP:0000148)2.02986646
92Generalized myoclonic seizures (HP:0002123)2.00503886
93CNS hypomyelination (HP:0003429)2.00431248
94Psychosis (HP:0000709)2.00155322
95Focal dystonia (HP:0004373)1.99798943
96Absent/shortened dynein arms (HP:0200106)1.99370059
97Dynein arm defect of respiratory motile cilia (HP:0012255)1.99370059
98Paraplegia (HP:0010550)1.97020956
99Abnormality of salivation (HP:0100755)1.95533090
100Esotropia (HP:0000565)1.95336859
101Amyotrophic lateral sclerosis (HP:0007354)1.93867595
102Hypoplasia of the corpus callosum (HP:0002079)1.93830193
103Delusions (HP:0000746)1.92989447
104Impaired vibratory sensation (HP:0002495)1.91692578
105Stereotypic behavior (HP:0000733)1.91634281
106Spastic tetraparesis (HP:0001285)1.90974076
107Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.89739843
108Aplasia/Hypoplasia of the brainstem (HP:0007362)1.89401197
109Hypoplasia of the brainstem (HP:0002365)1.89401197
110Apathy (HP:0000741)1.89338643
111Gait ataxia (HP:0002066)1.88569948
112Muscular hypotonia of the trunk (HP:0008936)1.88473729
113Nephrogenic diabetes insipidus (HP:0009806)1.86933135
114Hemiplegia (HP:0002301)1.86839860
115Megalencephaly (HP:0001355)1.86025879
116Clonus (HP:0002169)1.85725310
117Spastic paraplegia (HP:0001258)1.83851900
118Protruding tongue (HP:0010808)1.83598967
119Impaired smooth pursuit (HP:0007772)1.83585060
120Pachygyria (HP:0001302)1.82846456
121Craniofacial dystonia (HP:0012179)1.82513621
122Abnormal ciliary motility (HP:0012262)1.81080900
123Abnormal mitochondria in muscle tissue (HP:0008316)1.78490784

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.89524878
2MARK13.73325810
3EPHA43.14345338
4MAP3K43.07845685
5MAP3K92.95079364
6PNCK2.76691919
7NTRK22.75505614
8MAP2K72.70325157
9MINK12.66875298
10MAP3K122.59433287
11CASK2.43251434
12TNIK2.34810518
13TRIM282.03434352
14MAP2K41.93616944
15NTRK11.92667095
16MAPK131.87403349
17PAK61.81602087
18STK391.74233614
19OXSR11.66722925
20CDK191.66437369
21UHMK11.61512537
22MAP4K21.61119552
23GRK51.49692899
24PLK21.45398163
25CDK51.43921718
26DAPK21.42068701
27CSNK1G21.35440226
28KSR21.34044276
29FES1.29365102
30PHKG21.24525431
31PHKG11.24525431
32ARAF1.22753891
33RIPK41.21628087
34CSNK1G31.17323194
35CAMK2A1.16581747
36KSR11.15477215
37PRKCG1.11784008
38ERBB31.11164095
39CAMK2B1.09718313
40SIK21.03714477
41TSSK61.00714557
42MAPKAPK50.95439607
43CDK140.95001769
44STK110.94108344
45CAMKK10.93578664
46SGK4940.92945778
47SGK2230.92945778
48CDK180.91837492
49WNK10.91270269
50CDK150.89934273
51WNK40.89895406
52PRKD30.89682207
53CSNK1A1L0.88180683
54TESK10.86857606
55BCR0.85100510
56CAMKK20.84867764
57PAK30.83545744
58PRPF4B0.83503484
59GRK70.83434736
60DYRK1A0.82736477
61TYRO30.81444336
62DAPK10.81151669
63PKN10.80393085
64FGR0.80181316
65CDK11A0.78811784
66LATS20.78735241
67CAMK2D0.77766853
68CSNK1G10.73641106
69MUSK0.70035084
70MAP3K20.69850276
71EPHA30.69071392
72PRKCE0.68633329
73FGFR20.68390606
74MARK20.67530713
75CAMK2G0.67292678
76CAMK10.66719022
77STK380.66319763
78BMPR20.65881958
79ADRBK20.65199272
80BMPR1B0.64794028
81NME10.62416511
82DYRK20.59758391
83MAP3K130.59075090
84ROCK20.58854175
85CCNB10.57594331
86DYRK1B0.56863473
87CAMK1G0.56419387
88SRPK10.55214442
89PRKCH0.54903947
90MAP3K60.54672831
91WNK30.54441182
92CAMK40.54155140
93LIMK10.54102891
94RET0.53856829
95NEK60.53561416
96MAP3K50.52380281
97ADRBK10.50272776
98ALK0.49435328
99FER0.49155893
100SGK10.46944033
101FYN0.46902097
102PIM20.46639381
103CSNK1D0.45640940
104PRKCZ0.44600071
105PDK10.44149286
106TNK20.43880180
107CSNK1E0.43635668
108PRKACA0.42880804
109CSNK1A10.42620758
110PDPK10.41808512
111RPS6KA40.40771686
112PLK30.40553045
113PINK10.39503154
114LMTK20.39347118
115SGK20.38292370
116PTK2B0.37840028
117MAPK100.37729201
118RPS6KA30.37442448
119STK38L0.36973212
120MKNK20.36146094
121SIK30.34361178
122PRKACB0.34336668
123PRKG10.29984130
124DAPK30.28695384
125BRSK10.28513502
126PRKCA0.28448238
127MAPK90.28079886
128PRKDC0.26718272
129PRKCB0.26567974

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.04778559
2Synaptic vesicle cycle_Homo sapiens_hsa047213.30701741
3GABAergic synapse_Homo sapiens_hsa047272.92667297
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.85612029
5Circadian entrainment_Homo sapiens_hsa047132.53371042
6Morphine addiction_Homo sapiens_hsa050322.51790201
7Glutamatergic synapse_Homo sapiens_hsa047242.48925742
8Long-term potentiation_Homo sapiens_hsa047202.42733200
9Olfactory transduction_Homo sapiens_hsa047402.25339987
10Amphetamine addiction_Homo sapiens_hsa050312.22096767
11Dopaminergic synapse_Homo sapiens_hsa047282.14376134
12Serotonergic synapse_Homo sapiens_hsa047262.07329888
13Taste transduction_Homo sapiens_hsa047422.04405487
14Collecting duct acid secretion_Homo sapiens_hsa049661.99442438
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.98941405
16Salivary secretion_Homo sapiens_hsa049701.96853107
17Insulin secretion_Homo sapiens_hsa049111.90643607
18Long-term depression_Homo sapiens_hsa047301.82553187
19Cholinergic synapse_Homo sapiens_hsa047251.79303650
20Oxidative phosphorylation_Homo sapiens_hsa001901.70095707
21Cocaine addiction_Homo sapiens_hsa050301.68937635
22Renin secretion_Homo sapiens_hsa049241.66343348
23Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.64555436
24Gastric acid secretion_Homo sapiens_hsa049711.63953586
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.48645545
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.48505135
27Calcium signaling pathway_Homo sapiens_hsa040201.42354535
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.41802496
29Oxytocin signaling pathway_Homo sapiens_hsa049211.40473239
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.38459609
31Gap junction_Homo sapiens_hsa045401.38410363
32Alzheimers disease_Homo sapiens_hsa050101.38102919
33Cardiac muscle contraction_Homo sapiens_hsa042601.38039681
34Parkinsons disease_Homo sapiens_hsa050121.36496376
35Axon guidance_Homo sapiens_hsa043601.34020079
36Vibrio cholerae infection_Homo sapiens_hsa051101.33502738
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.30769003
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.30098837
39GnRH signaling pathway_Homo sapiens_hsa049121.25230330
40Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.09818884
41Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.06683351
42cAMP signaling pathway_Homo sapiens_hsa040241.02918799
43Phototransduction_Homo sapiens_hsa047441.02040050
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.99413810
45ErbB signaling pathway_Homo sapiens_hsa040120.97023726
46Estrogen signaling pathway_Homo sapiens_hsa049150.95853397
47Vitamin B6 metabolism_Homo sapiens_hsa007500.93450772
48Melanogenesis_Homo sapiens_hsa049160.92163956
49Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.91152666
50Phosphatidylinositol signaling system_Homo sapiens_hsa040700.91060507
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.89649508
52Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.87418912
53Huntingtons disease_Homo sapiens_hsa050160.87006298
54Pancreatic secretion_Homo sapiens_hsa049720.86931134
55Oocyte meiosis_Homo sapiens_hsa041140.82464428
56Type II diabetes mellitus_Homo sapiens_hsa049300.82382807
57cGMP-PKG signaling pathway_Homo sapiens_hsa040220.78053675
58Butanoate metabolism_Homo sapiens_hsa006500.77165304
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75192325
60Dorso-ventral axis formation_Homo sapiens_hsa043200.72677286
61Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.71062941
62Protein export_Homo sapiens_hsa030600.69787341
63Phospholipase D signaling pathway_Homo sapiens_hsa040720.69289510
64Thyroid hormone synthesis_Homo sapiens_hsa049180.68052611
65Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.66525759
66Glioma_Homo sapiens_hsa052140.66226950
67Regulation of autophagy_Homo sapiens_hsa041400.65627030
682-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.65616826
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63744447
70beta-Alanine metabolism_Homo sapiens_hsa004100.63090534
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.61520060
72MAPK signaling pathway_Homo sapiens_hsa040100.60238782
73Ras signaling pathway_Homo sapiens_hsa040140.60160646
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.58927472
75Circadian rhythm_Homo sapiens_hsa047100.57655392
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57594931
77Ether lipid metabolism_Homo sapiens_hsa005650.57370825
78Alcoholism_Homo sapiens_hsa050340.55778724
79Fatty acid elongation_Homo sapiens_hsa000620.54496895
80Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54030960
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.53362606
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51972247
83Arginine and proline metabolism_Homo sapiens_hsa003300.51574986
84Choline metabolism in cancer_Homo sapiens_hsa052310.51112778
85Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50787211
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50216743
87Dilated cardiomyopathy_Homo sapiens_hsa054140.49861374
88Renal cell carcinoma_Homo sapiens_hsa052110.47525480
89Type I diabetes mellitus_Homo sapiens_hsa049400.47197631
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46949274
91Ovarian steroidogenesis_Homo sapiens_hsa049130.46054078
92Steroid biosynthesis_Homo sapiens_hsa001000.46000119
93Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.45034222
94Inositol phosphate metabolism_Homo sapiens_hsa005620.44637729
95Hippo signaling pathway_Homo sapiens_hsa043900.44507139
96Rheumatoid arthritis_Homo sapiens_hsa053230.44458653
97Rap1 signaling pathway_Homo sapiens_hsa040150.41983157
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41566359
99Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.39251820
100Propanoate metabolism_Homo sapiens_hsa006400.38105066
101Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.37339000
102African trypanosomiasis_Homo sapiens_hsa051430.35213967
103Tight junction_Homo sapiens_hsa045300.35024792
104Endocytosis_Homo sapiens_hsa041440.34928715
105Wnt signaling pathway_Homo sapiens_hsa043100.34719691
106mRNA surveillance pathway_Homo sapiens_hsa030150.34692280
107Prion diseases_Homo sapiens_hsa050200.33930843
108Neurotrophin signaling pathway_Homo sapiens_hsa047220.33779835
109Phagosome_Homo sapiens_hsa041450.33615488
110Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33480264
111Bile secretion_Homo sapiens_hsa049760.32246902
112Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31190204
113AMPK signaling pathway_Homo sapiens_hsa041520.30584216
114Glucagon signaling pathway_Homo sapiens_hsa049220.30416134
115VEGF signaling pathway_Homo sapiens_hsa043700.27852435
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27057783
117Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.26846181
118Biosynthesis of amino acids_Homo sapiens_hsa012300.25699556
119Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.22933087

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