NAP1L4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the nucleosome assembly protein (NAP) family which can interact with both core and linker histones. It can shuttle between the cytoplasm and nucleus, suggesting a role as a histone chaperone. This gene is one of several located near the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.44546100
2DNA strand elongation involved in DNA replication (GO:0006271)4.60981918
3DNA strand elongation (GO:0022616)4.35125031
4DNA topological change (GO:0006265)4.24606885
5negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.08584619
6telomere maintenance via semi-conservative replication (GO:0032201)4.03759835
7DNA replication initiation (GO:0006270)4.03336984
8establishment of viral latency (GO:0019043)3.97219805
9DNA replication-dependent nucleosome organization (GO:0034723)3.93729862
10DNA replication-dependent nucleosome assembly (GO:0006335)3.93729862
11mitotic nuclear envelope disassembly (GO:0007077)3.93344406
12protein localization to kinetochore (GO:0034501)3.88730801
13IMP biosynthetic process (GO:0006188)3.88103414
14mitotic chromosome condensation (GO:0007076)3.80267866
15membrane disassembly (GO:0030397)3.73168490
16nuclear envelope disassembly (GO:0051081)3.73168490
17pore complex assembly (GO:0046931)3.68501721
18DNA ligation (GO:0006266)3.65827524
19negative regulation of RNA splicing (GO:0033119)3.64123842
20dosage compensation (GO:0007549)3.63455032
21IMP metabolic process (GO:0046040)3.59413597
22histone arginine methylation (GO:0034969)3.51706946
23nuclear pore organization (GO:0006999)3.50601915
24telomere maintenance via recombination (GO:0000722)3.45382349
25translesion synthesis (GO:0019985)3.44452543
26mitotic recombination (GO:0006312)3.44197377
27regulation of translational termination (GO:0006449)3.40692680
28nuclear pore complex assembly (GO:0051292)3.35116048
29folic acid-containing compound biosynthetic process (GO:0009396)3.32068463
30postreplication repair (GO:0006301)3.31426209
31peptidyl-arginine omega-N-methylation (GO:0035247)3.29008137
32formation of translation preinitiation complex (GO:0001731)3.29004923
33regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.27927546
34spliceosomal tri-snRNP complex assembly (GO:0000244)3.27880180
35DNA duplex unwinding (GO:0032508)3.27772461
36DNA geometric change (GO:0032392)3.27219639
37protein localization to chromosome, centromeric region (GO:0071459)3.21893842
38ribosomal small subunit assembly (GO:0000028)3.21453256
39negative regulation of mRNA processing (GO:0050686)3.20259248
40non-recombinational repair (GO:0000726)3.18838884
41double-strand break repair via nonhomologous end joining (GO:0006303)3.18838884
42DNA replication checkpoint (GO:0000076)3.18117946
43nucleobase biosynthetic process (GO:0046112)3.17670354
44pre-miRNA processing (GO:0031054)3.15332037
45nucleotide-excision repair, DNA gap filling (GO:0006297)3.11517797
46deoxyribonucleotide biosynthetic process (GO:0009263)3.10331633
47negative regulation of histone methylation (GO:0031061)3.08084536
48heterochromatin organization (GO:0070828)3.07231893
49telomere maintenance via telomere lengthening (GO:0010833)3.06818436
50peptidyl-lysine dimethylation (GO:0018027)3.06654564
51nuclear envelope organization (GO:0006998)3.06334624
52regulation of translational fidelity (GO:0006450)3.04321701
53sister chromatid segregation (GO:0000819)3.03703853
54histone H2A acetylation (GO:0043968)3.03416381
55maturation of SSU-rRNA (GO:0030490)3.01633525
56regulation of mitotic spindle organization (GO:0060236)2.99327879
57DNA synthesis involved in DNA repair (GO:0000731)2.99231436
58mitotic sister chromatid segregation (GO:0000070)2.99050615
59mitotic metaphase plate congression (GO:0007080)2.98318242
60V(D)J recombination (GO:0033151)2.97279009
61histone H2A monoubiquitination (GO:0035518)2.95802980
62mitotic spindle assembly checkpoint (GO:0007094)2.95436832
63regulation of RNA export from nucleus (GO:0046831)2.94045951
64negative regulation of chromosome segregation (GO:0051985)2.93933863
65regulation of double-strand break repair via homologous recombination (GO:0010569)2.92616743
66RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.92299818
67mRNA splicing, via spliceosome (GO:0000398)2.92299818
68negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.92068971
69negative regulation of sister chromatid segregation (GO:0033046)2.92068971
70negative regulation of mitotic sister chromatid separation (GO:2000816)2.92068971
71negative regulation of mitotic sister chromatid segregation (GO:0033048)2.92068971
72spindle assembly checkpoint (GO:0071173)2.90546094
73tRNA aminoacylation for protein translation (GO:0006418)2.90326773
74peptidyl-arginine methylation (GO:0018216)2.87223119
75peptidyl-arginine N-methylation (GO:0035246)2.87223119
76purine nucleobase biosynthetic process (GO:0009113)2.86561825
77mitotic sister chromatid cohesion (GO:0007064)2.86499300
78nucleobase-containing small molecule interconversion (GO:0015949)2.86105219
79COPI coating of Golgi vesicle (GO:0048205)2.85912947
80Golgi transport vesicle coating (GO:0048200)2.85912947
81RNA splicing, via transesterification reactions (GO:0000375)2.85911891
82DNA replication-independent nucleosome organization (GO:0034724)2.85604474
83DNA replication-independent nucleosome assembly (GO:0006336)2.85604474
84negative regulation of mRNA metabolic process (GO:1903312)2.85164150
85protoporphyrinogen IX metabolic process (GO:0046501)2.84888731
86negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.84284266
87regulation of chromosome segregation (GO:0051983)2.83015117
88DNA damage response, detection of DNA damage (GO:0042769)2.82588676
89amino acid activation (GO:0043038)2.82442949
90tRNA aminoacylation (GO:0043039)2.82442949
91regulation of sister chromatid cohesion (GO:0007063)2.80632083
92de novo protein folding (GO:0006458)2.80347978
93regulation of spindle organization (GO:0090224)2.80116569
94ATP-dependent chromatin remodeling (GO:0043044)2.80003474
95establishment of mitochondrion localization (GO:0051654)2.79265975
96chromatin assembly or disassembly (GO:0006333)2.77644631
97de novo posttranslational protein folding (GO:0051084)2.73450247
98spliceosomal snRNP assembly (GO:0000387)2.73070342
99mitotic G1 DNA damage checkpoint (GO:0031571)2.72041276
100regulation of protein heterodimerization activity (GO:0043497)2.72022287
101protein maturation by protein folding (GO:0022417)2.70685200
102negative regulation of microtubule polymerization (GO:0031115)2.70655753
103regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.69880463
104mRNA export from nucleus (GO:0006406)2.69823521
105protein localization to chromosome (GO:0034502)2.69432664
106RNA export from nucleus (GO:0006405)2.68860183
107DNA conformation change (GO:0071103)2.68583561
108protein-DNA complex disassembly (GO:0032986)2.68145039
109nucleosome disassembly (GO:0006337)2.68145039
110mRNA transport (GO:0051028)2.67202220
111pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.67186870
112base-excision repair (GO:0006284)2.66532064
113mitotic spindle checkpoint (GO:0071174)2.65726376
114pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.65689361
115establishment of integrated proviral latency (GO:0075713)2.65639426
116viral mRNA export from host cell nucleus (GO:0046784)2.64881659
117mRNA splice site selection (GO:0006376)2.63842894
118regulation of mitochondrial translation (GO:0070129)2.62923308
119ribosome biogenesis (GO:0042254)2.62085202
120protein complex localization (GO:0031503)2.61790691
121spindle checkpoint (GO:0031577)2.61236835
122chromatin remodeling at centromere (GO:0031055)2.60253782
123regulation of mitotic metaphase/anaphase transition (GO:0030071)2.59920564
124CENP-A containing nucleosome assembly (GO:0034080)2.59705457
125ribosome assembly (GO:0042255)2.58554624
126deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.57889247
127metaphase plate congression (GO:0051310)2.57601416
128chromosome condensation (GO:0030261)2.57038407
129spliceosomal complex assembly (GO:0000245)2.55711714
130translational elongation (GO:0006414)2.55333334
131tricarboxylic acid cycle (GO:0006099)2.55168463
132translational initiation (GO:0006413)2.54864349
133regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.54635755
134termination of RNA polymerase II transcription (GO:0006369)2.54538291
1353-UTR-mediated mRNA stabilization (GO:0070935)2.54438893

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.30599922
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.16721078
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.07620407
4* MYC_18555785_ChIP-Seq_MESCs_Mouse3.55712536
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.09845326
6MYC_22102868_ChIP-Seq_BL_Human3.08048735
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.66615683
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.56268071
9MYC_19030024_ChIP-ChIP_MESCs_Mouse2.35002411
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.31234725
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.31122271
12XRN2_22483619_ChIP-Seq_HELA_Human2.26836119
13CIITA_25753668_ChIP-Seq_RAJI_Human2.21870751
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.21639137
15* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.13722384
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.13287424
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.07840441
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.96829167
19EST1_17652178_ChIP-ChIP_JURKAT_Human1.93843849
20CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.93637920
21E2F1_21310950_ChIP-Seq_MCF-7_Human1.90120026
22CREB1_15753290_ChIP-ChIP_HEK293T_Human1.89629018
23JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.84560059
24* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.83553596
25AR_21909140_ChIP-Seq_LNCAP_Human1.83318571
26VDR_21846776_ChIP-Seq_THP-1_Human1.80335889
27THAP11_20581084_ChIP-Seq_MESCs_Mouse1.76183216
28GABP_19822575_ChIP-Seq_HepG2_Human1.76100265
29TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.70342234
30TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67006766
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.65417531
32GABP_17652178_ChIP-ChIP_JURKAT_Human1.65193550
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65117020
34MYCN_18555785_ChIP-Seq_MESCs_Mouse1.64148486
35VDR_23849224_ChIP-Seq_CD4+_Human1.61782968
36E2F1_18555785_ChIP-Seq_MESCs_Mouse1.60555421
37PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.60403332
38* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.58315229
39NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.57357199
40TTF2_22483619_ChIP-Seq_HELA_Human1.56647967
41* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.55152487
42ELF1_17652178_ChIP-ChIP_JURKAT_Human1.54459567
43PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.52343181
44KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.50906750
45FOXP3_21729870_ChIP-Seq_TREG_Human1.50176086
46MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.47390344
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45417485
48KDM5A_27292631_Chip-Seq_BREAST_Human1.44380461
49POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.44315499
50DCP1A_22483619_ChIP-Seq_HELA_Human1.44021185
51DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.43137876
52KLF4_18555785_ChIP-Seq_MESCs_Mouse1.41778977
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.40758306
54* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.39127743
55ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.38094257
56NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.33195751
57ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.28510878
58TCF7_22412390_ChIP-Seq_EML_Mouse1.26164382
59* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.26120569
60NANOG_18555785_ChIP-Seq_MESCs_Mouse1.24752174
61SRF_21415370_ChIP-Seq_HL-1_Mouse1.23048040
62SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.22404276
63ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.21671230
64* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.21280416
65UTX_26944678_Chip-Seq_JUKART_Human1.21162638
66KDM2B_26808549_Chip-Seq_DND41_Human1.20990458
67DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.19849481
68ELK3_25401928_ChIP-Seq_HUVEC_Human1.19585600
69* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.16382580
70KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.15946231
71STAT3_1855785_ChIP-Seq_MESCs_Mouse1.15752202
72FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.15636010
73SOX2_18555785_ChIP-Seq_MESCs_Mouse1.14992133
74SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.14906823
75POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.13455697
76* MAF_26560356_Chip-Seq_TH1_Human1.12817001
77NANOG_21062744_ChIP-ChIP_HESCs_Human1.12532521
78POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.12365261
79ZFP281_18757296_ChIP-ChIP_E14_Mouse1.10758323
80* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.09123999
81TP63_19390658_ChIP-ChIP_HaCaT_Human1.08833953
82ZNF263_19887448_ChIP-Seq_K562_Human1.08424319
83HOXB4_20404135_ChIP-ChIP_EML_Mouse1.08298344
84BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.07937089
85CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.07294290
86* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.07131800
87SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.07123334
88PADI4_21655091_ChIP-ChIP_MCF-7_Human1.05479520
89TFEB_21752829_ChIP-Seq_HELA_Human1.05231799
90KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.01183121
91HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00847139
92ESR1_15608294_ChIP-ChIP_MCF-7_Human1.00719464
93FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.99311672
94YY1_21170310_ChIP-Seq_MESCs_Mouse0.99296507
95* SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.99259135
96KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.95553266
97SRY_22984422_ChIP-ChIP_TESTIS_Rat0.95221688
98GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.94252295
99ATF3_27146783_Chip-Seq_COLON_Human0.93556947
100MAF_26560356_Chip-Seq_TH2_Human0.93436727
101CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.92598609
102RBPJ_22232070_ChIP-Seq_NCS_Mouse0.91341643
103HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.91134692
104NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.88801664
105TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88485911
106TBX5_21415370_ChIP-Seq_HL-1_Mouse0.87544740
107* CHD1_26751641_Chip-Seq_LNCaP_Human0.87433199
108CLOCK_20551151_ChIP-Seq_293T_Human0.87242976
109TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.86389904
110CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.85980825
111* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.85932055
112ELK1_19687146_ChIP-ChIP_HELA_Human0.85703477
113TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.85123270
114* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.84373978
115TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.84209293
116* P68_20966046_ChIP-Seq_HELA_Human0.83330364

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.54541957
2MP0010094_abnormal_chromosome_stability3.39491091
3MP0003111_abnormal_nucleus_morphology3.29039662
4MP0004957_abnormal_blastocyst_morpholog3.22962794
5MP0003077_abnormal_cell_cycle3.10031817
6MP0003123_paternal_imprinting2.64096904
7MP0004084_abnormal_cardiac_muscle2.56078888
8MP0001730_embryonic_growth_arrest2.33842916
9MP0008007_abnormal_cellular_replicative2.33822210
10MP0002653_abnormal_ependyma_morphology2.30191558
11MP0002396_abnormal_hematopoietic_system2.25676552
12MP0003646_muscle_fatigue2.10513728
13MP0010030_abnormal_orbit_morphology2.09101333
14MP0004233_abnormal_muscle_weight2.08366666
15MP0002822_catalepsy2.06687822
16MP0000751_myopathy2.01706636
17MP0001529_abnormal_vocalization2.00097360
18MP0005499_abnormal_olfactory_system1.98290871
19MP0005394_taste/olfaction_phenotype1.98290871
20MP0000350_abnormal_cell_proliferation1.95646885
21MP0008260_abnormal_autophagy1.93388766
22MP0010352_gastrointestinal_tract_polyps1.88462673
23MP0004808_abnormal_hematopoietic_stem1.80337401
24MP0006035_abnormal_mitochondrial_morpho1.78566231
25MP0008058_abnormal_DNA_repair1.77010510
26MP0003567_abnormal_fetal_cardiomyocyte1.76752348
27MP0009697_abnormal_copulation1.75826387
28MP0008932_abnormal_embryonic_tissue1.75798099
29MP0008789_abnormal_olfactory_epithelium1.74930288
30MP0005380_embryogenesis_phenotype1.71828384
31MP0001672_abnormal_embryogenesis/_devel1.71828384
32MP0001697_abnormal_embryo_size1.71746722
33MP0003221_abnormal_cardiomyocyte_apopto1.71651475
34MP0000537_abnormal_urethra_morphology1.69212421
35MP0002080_prenatal_lethality1.65060283
36MP0006054_spinal_hemorrhage1.64859846
37MP0003984_embryonic_growth_retardation1.64413026
38MP0002088_abnormal_embryonic_growth/wei1.63882361
39MP0004147_increased_porphyrin_level1.62385028
40MP0003121_genomic_imprinting1.61394778
41MP0002085_abnormal_embryonic_tissue1.61308335
42MP0005076_abnormal_cell_differentiation1.61112145
43MP0004197_abnormal_fetal_growth/weight/1.59898049
44MP0002084_abnormal_developmental_patter1.59225588
45MP0004859_abnormal_synaptic_plasticity1.57316416
46MP0000749_muscle_degeneration1.56106314
47MP0008877_abnormal_DNA_methylation1.55321126
48MP0003763_abnormal_thymus_physiology1.53722529
49MP0002269_muscular_atrophy1.50092342
50MP0005451_abnormal_body_composition1.49552842
51MP0004087_abnormal_muscle_fiber1.49262964
52MP0003705_abnormal_hypodermis_morpholog1.46873625
53MP0004036_abnormal_muscle_relaxation1.46078334
54MP0001188_hyperpigmentation1.42079602
55MP0000750_abnormal_muscle_regeneration1.41774051
56MP0008057_abnormal_DNA_replication1.40991158
57MP0002106_abnormal_muscle_physiology1.38971638
58MP0010307_abnormal_tumor_latency1.35320914
59MP0000733_abnormal_muscle_development1.31518371
60MP0002086_abnormal_extraembryonic_tissu1.30413226
61MP0005330_cardiomyopathy1.30236272
62MP0003385_abnormal_body_wall1.29831585
63MP0000747_muscle_weakness1.29529240
64MP0010630_abnormal_cardiac_muscle1.27839925
65MP0000313_abnormal_cell_death1.26968987
66MP0006036_abnormal_mitochondrial_physio1.24749261
67MP0000490_abnormal_crypts_of1.24568547
68MP0004145_abnormal_muscle_electrophysio1.22865378
69MP0005187_abnormal_penis_morphology1.21470801
70MP0000703_abnormal_thymus_morphology1.20562879
71MP0002019_abnormal_tumor_incidence1.17683709
72MP0003656_abnormal_erythrocyte_physiolo1.16803658
73MP0000759_abnormal_skeletal_muscle1.16389597
74MP0002009_preneoplasia1.16374273
75MP0001849_ear_inflammation1.15365364
76MP0002697_abnormal_eye_size1.12641147
77MP0004811_abnormal_neuron_physiology1.12243041
78MP0004215_abnormal_myocardial_fiber1.12182892
79MP0000428_abnormal_craniofacial_morphol1.09361902
80MP0008961_abnormal_basal_metabolism1.07963259
81MP0001915_intracranial_hemorrhage1.04615707
82MP0008995_early_reproductive_senescence1.04276175
83MP0002837_dystrophic_cardiac_calcinosis1.03632952
84MP0005369_muscle_phenotype1.03349555
85MP0003119_abnormal_digestive_system1.02283347
86MP0009672_abnormal_birth_weight0.98422961
87MP0003787_abnormal_imprinting0.98368902
88MP0000266_abnormal_heart_morphology0.97599770
89MP0001661_extended_life_span0.96781056
90MP0002089_abnormal_postnatal_growth/wei0.95669072
91MP0003122_maternal_imprinting0.95616008
92MP0005621_abnormal_cell_physiology0.95457833
93MP0001544_abnormal_cardiovascular_syste0.93461634
94MP0005385_cardiovascular_system_phenoty0.93461634
95MP0003115_abnormal_respiratory_system0.92363160
96MP0002234_abnormal_pharynx_morphology0.91472701
97MP0003566_abnormal_cell_adhesion0.90104995
98MP0009053_abnormal_anal_canal0.89721736
99MP0009278_abnormal_bone_marrow0.89720465
100MP0002398_abnormal_bone_marrow0.89159202
101MP0002877_abnormal_melanocyte_morpholog0.88745351
102MP0001346_abnormal_lacrimal_gland0.88536488
103MP0005501_abnormal_skin_physiology0.88344731
104MP0000358_abnormal_cell_content/0.88099977
105MP0001348_abnormal_lacrimal_gland0.85168672
106MP0001299_abnormal_eye_distance/0.84545917
107MP0009333_abnormal_splenocyte_physiolog0.84221136
108MP0006276_abnormal_autonomic_nervous0.83744466
109MP0001929_abnormal_gametogenesis0.81619726
110MP0002932_abnormal_joint_morphology0.80688295
111MP0004270_analgesia0.80380162
112MP0005397_hematopoietic_system_phenotyp0.79726021
113MP0001545_abnormal_hematopoietic_system0.79726021
114MP0003315_abnormal_perineum_morphology0.79418832
115MP0002722_abnormal_immune_system0.79385463
116MP0002925_abnormal_cardiovascular_devel0.79348173
117MP0002210_abnormal_sex_determination0.78006231
118MP0001984_abnormal_olfaction0.77738555
119MP0005083_abnormal_biliary_tract0.76495540
120MP0003718_maternal_effect0.75795007
121MP0003786_premature_aging0.74934719
122MP0008775_abnormal_heart_ventricle0.72782414
123MP0003942_abnormal_urinary_system0.72205431
124MP0003935_abnormal_craniofacial_develop0.72117297
125MP0004185_abnormal_adipocyte_glucose0.72098983
126MP0008770_decreased_survivor_rate0.71974049
127MP0009703_decreased_birth_body0.71505093
128MP0005384_cellular_phenotype0.71482494
129MP0003861_abnormal_nervous_system0.70528496
130MP0002092_abnormal_eye_morphology0.70207886
131MP0000465_gastrointestinal_hemorrhage0.69990190
132MP0001293_anophthalmia0.69990178
133MP0002081_perinatal_lethality0.68419647
134MP0001270_distended_abdomen0.65114244
135MP0003698_abnormal_male_reproductive0.63507345
136MP0002152_abnormal_brain_morphology0.62865681
137MP0010768_mortality/aging0.61383211
138MP0001145_abnormal_male_reproductive0.60289731
139MP0000778_abnormal_nervous_system0.60163187

Predicted human phenotypes

RankGene SetZ-score
1Hyperacusis (HP:0010780)4.01689239
2Nuclear cataract (HP:0100018)3.63194622
3Ragged-red muscle fibers (HP:0003200)3.36293253
4Cortical dysplasia (HP:0002539)3.35586463
5Microvesicular hepatic steatosis (HP:0001414)3.30517117
6Ependymoma (HP:0002888)3.25164514
7Chromsome breakage (HP:0040012)3.01723343
8Renal duplication (HP:0000075)3.00786436
9Colon cancer (HP:0003003)2.99274671
10Chromosomal breakage induced by crosslinking agents (HP:0003221)2.98917838
11Abnormal gallbladder physiology (HP:0012438)2.97981077
12Cholecystitis (HP:0001082)2.97981077
13Progressive external ophthalmoplegia (HP:0000590)2.96666301
14Pelvic girdle muscle weakness (HP:0003749)2.94598635
15Selective tooth agenesis (HP:0001592)2.93235342
16Exercise-induced muscle cramps (HP:0003710)2.90732691
17Increased nuchal translucency (HP:0010880)2.90540415
18Short 4th metacarpal (HP:0010044)2.87638823
19Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.87638823
20Abnormality of glycolysis (HP:0004366)2.85163199
21Shoulder girdle muscle weakness (HP:0003547)2.84646612
22Zonular cataract (HP:0010920)2.80584756
23Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.79829570
24High anterior hairline (HP:0009890)2.76929897
25Multiple enchondromatosis (HP:0005701)2.75845083
26Myoglobinuria (HP:0002913)2.69388127
27Abnormality of the musculature of the pelvis (HP:0001469)2.58061561
28Abnormality of the hip-girdle musculature (HP:0001445)2.58061561
29Increased serum pyruvate (HP:0003542)2.56847284
30Abnormality of the 4th metacarpal (HP:0010012)2.50300963
31Subaortic stenosis (HP:0001682)2.47281157
32Abnormality of the left ventricular outflow tract (HP:0011103)2.47281157
33Overriding aorta (HP:0002623)2.44718020
34Rhabdomyolysis (HP:0003201)2.39339637
35Medulloblastoma (HP:0002885)2.37440646
36Limb-girdle muscle atrophy (HP:0003797)2.36927055
37Elfin facies (HP:0004428)2.36785882
38Abnormality of the calcaneus (HP:0008364)2.35473069
39Spastic diplegia (HP:0001264)2.31964453
40Muscle fiber inclusion bodies (HP:0100299)2.31381823
41Exercise-induced myalgia (HP:0003738)2.31332277
42Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.29296591
43Birth length less than 3rd percentile (HP:0003561)2.28364130
44Insomnia (HP:0100785)2.26159325
45Renovascular hypertension (HP:0100817)2.24809558
46Deep palmar crease (HP:0006191)2.22606592
47Patellar aplasia (HP:0006443)2.21620813
48Abnormality of the astrocytes (HP:0100707)2.20918942
49Astrocytoma (HP:0009592)2.20918942
50Reticulocytosis (HP:0001923)2.20738913
51Abnormal number of incisors (HP:0011064)2.20424623
52Poikiloderma (HP:0001029)2.19287166
53Difficulty climbing stairs (HP:0003551)2.17403480
54Calcaneovalgus deformity (HP:0001848)2.16996267
55Increased density of long bones (HP:0006392)2.16987946
56Termporal pattern (HP:0011008)2.14308617
57Insidious onset (HP:0003587)2.14308617
58Angiofibromas (HP:0010615)2.12993892
59Adenoma sebaceum (HP:0009720)2.12993892
60Aplasia/Hypoplasia of the patella (HP:0006498)2.11632368
61Pointed chin (HP:0000307)2.11571666
62High pitched voice (HP:0001620)2.11491762
63Hepatoblastoma (HP:0002884)2.11242145
64Abnormality of the labia minora (HP:0012880)2.10555538
65Slender long bone (HP:0003100)2.09658744
66Abnormality of the anterior horn cell (HP:0006802)2.09380286
67Degeneration of anterior horn cells (HP:0002398)2.09380286
68Deformed tarsal bones (HP:0008119)2.07988728
69Aplastic anemia (HP:0001915)2.07975356
70Nemaline bodies (HP:0003798)2.05930616
71Difficulty running (HP:0009046)2.04915607
72Postnatal microcephaly (HP:0005484)2.04630867
73Muscle fiber splitting (HP:0003555)2.03841672
74Proximal placement of thumb (HP:0009623)2.01352943
75Hand muscle atrophy (HP:0009130)2.01316773
76Urinary urgency (HP:0000012)2.01037907
77Ulnar deviation of the wrist (HP:0003049)2.00717541
78Abnormality of the lower motor neuron (HP:0002366)2.00695622
79Basal cell carcinoma (HP:0002671)1.99619921
80Peripheral hypomyelination (HP:0007182)1.97880376
81Prominent metopic ridge (HP:0005487)1.97566686
82Cholelithiasis (HP:0001081)1.97462682
83Missing ribs (HP:0000921)1.96945562
84Abnormality of the metopic suture (HP:0005556)1.95814509
85Bowel diverticulosis (HP:0005222)1.95387223
86Oral leukoplakia (HP:0002745)1.94778246
87Flat cornea (HP:0007720)1.93464409
88Abnormality of the heme biosynthetic pathway (HP:0010472)1.93271713
89Nephroblastoma (Wilms tumor) (HP:0002667)1.92651114
90Long palpebral fissure (HP:0000637)1.91931379
91Posterior subcapsular cataract (HP:0007787)1.91346760
92Limb-girdle muscle weakness (HP:0003325)1.90663197
93Glioma (HP:0009733)1.90042584
94Deviation of the thumb (HP:0009603)1.89771314
95Amyotrophic lateral sclerosis (HP:0007354)1.89580224
96Progressive muscle weakness (HP:0003323)1.89552138
97Abnormality of reticulocytes (HP:0004312)1.89190677
98Distal arthrogryposis (HP:0005684)1.88746557
99Back pain (HP:0003418)1.87350713
100Failure to thrive in infancy (HP:0001531)1.87222712
101Rimmed vacuoles (HP:0003805)1.87108263
102Broad palm (HP:0001169)1.86572754
103Hypoplasia of the capital femoral epiphysis (HP:0003090)1.85974728
104Thrombocytosis (HP:0001894)1.85960100
105Myotonia (HP:0002486)1.85170923
106Megalocornea (HP:0000485)1.84305275
107Neoplasm of the adrenal gland (HP:0100631)1.83134089
108Ventricular tachycardia (HP:0004756)1.82854543
109Centrally nucleated skeletal muscle fibers (HP:0003687)1.82183374
110Neoplasm of the pancreas (HP:0002894)1.80090292
111Entropion (HP:0000621)1.79987052
112Type 1 muscle fiber predominance (HP:0003803)1.79565633
113Sacral dimple (HP:0000960)1.79087617
114Bicuspid aortic valve (HP:0001647)1.78865901
115Intestinal polyp (HP:0005266)1.78481974
116Amaurosis fugax (HP:0100576)1.78416912
117Prominent nose (HP:0000448)1.78291576
118Cerebral hypomyelination (HP:0006808)1.78132305
119External ophthalmoplegia (HP:0000544)1.77830235
120Increased connective tissue (HP:0009025)1.77302561
121Intestinal polyposis (HP:0200008)1.77056641
122Sudden death (HP:0001699)1.74302571
123Embryonal renal neoplasm (HP:0011794)1.73227652
124Distal lower limb amyotrophy (HP:0008944)1.72936114
125Horseshoe kidney (HP:0000085)1.72043309
126Myopathic facies (HP:0002058)1.70463014
127Vertebral arch anomaly (HP:0008438)1.70144680
128Atrophy/Degeneration involving motor neurons (HP:0007373)1.69426669
129Cafe-au-lait spot (HP:0000957)1.69286576
130Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.69143901
131Decreased activity of mitochondrial respiratory chain (HP:0008972)1.69143901
132Proximal amyotrophy (HP:0007126)1.68855439
133Trismus (HP:0000211)1.68634090
134Abnormal gallbladder morphology (HP:0012437)1.67584827
135Trigonocephaly (HP:0000243)1.67408126
136Distal upper limb amyotrophy (HP:0007149)1.66988596
137Upper limb amyotrophy (HP:0009129)1.66988596
138Atresia of the external auditory canal (HP:0000413)1.66603807
139Obsessive-compulsive behavior (HP:0000722)1.66513639
140Severe combined immunodeficiency (HP:0004430)1.66291681
141Fibroma (HP:0010614)1.65622701
142Resting tremor (HP:0002322)1.65458403
143Squamous cell carcinoma (HP:0002860)1.65302051
144Scapular winging (HP:0003691)1.65032346
145Cerebral aneurysm (HP:0004944)1.64293184
146Premature ovarian failure (HP:0008209)1.64199975
147Combined immunodeficiency (HP:0005387)1.64081158
148Long clavicles (HP:0000890)1.63510919
149Protrusio acetabuli (HP:0003179)1.63164816
150IgM deficiency (HP:0002850)1.62654853
151Adducted thumb (HP:0001181)1.62435660
152Absent epiphyses (HP:0010577)1.62313091
153Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.62313091
154Orthostatic hypotension (HP:0001278)1.61983586
155Volvulus (HP:0002580)1.61451906
156Abnormality of chromosome stability (HP:0003220)1.60992914
157Rectal prolapse (HP:0002035)1.60831295
158Bladder diverticulum (HP:0000015)1.59865508
159Spina bifida occulta (HP:0003298)1.59275526
160Myelodysplasia (HP:0002863)1.58535040
161Lower limb amyotrophy (HP:0007210)1.58464969
162Gout (HP:0001997)1.58320054
163Aortic aneurysm (HP:0004942)1.58071235
164Fibrous tissue neoplasm (HP:0012316)1.57590814

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PASK4.11078060
2PKN23.84604114
3TRIB33.75381957
4EEF2K3.52233534
5CDC73.49584960
6NEK12.81343797
7BUB12.50791754
8MAP3K102.34224357
9NEK22.30865457
10WEE12.30533987
11TTN2.28980315
12BCR2.25583147
13ACVR1B2.19480646
14SCYL22.00740048
15TGFBR11.98286672
16FLT31.89196515
17VRK21.75266897
18PBK1.71480783
19TESK21.69155502
20ARAF1.63582794
21RPS6KB21.58658184
22TSSK61.57896758
23PAK41.57650752
24SMG11.51007715
25MAP2K71.50731160
26LRRK21.49133645
27STK161.43872634
28PDK31.34769824
29PDK41.34769824
30TESK11.32996957
31PDK21.31709205
32CDK41.31072949
33STK101.29178417
34MAP4K11.28483102
35MAP3K41.24081269
36BRSK11.20732962
37ATR1.16963798
38LIMK11.14200072
39TTK1.14198153
40CSNK1G31.13427916
41BRSK21.11801633
42PLK11.10776339
43KSR11.09954426
44MAPKAPK31.08135203
45CDK141.07817860
46CDK191.04138706
47PRPF4B1.03000859
48MAP3K81.01923777
49ILK1.00292806
50LMTK21.00097298
51AURKB0.97424523
52PDGFRA0.97107974
53CSNK1A1L0.96350836
54CDK11A0.95560826
55DAPK10.95537237
56CDK180.94891572
57SRPK10.94379563
58DYRK30.94122931
59CDK120.93771780
60CDK150.92122266
61ALK0.91083888
62NTRK10.90739206
63CAMKK10.90320276
64CHEK10.89133413
65MKNK10.87505560
66PHKG10.87293473
67PHKG20.87293473
68RPS6KA40.85473429
69PIM20.84118065
70PTK60.83097019
71TRIM280.82447005
72CCNB10.79531470
73CLK10.79496791
74CSNK1G20.78913098
75PLK40.77900377
76CSNK1G10.77829418
77FGFR10.77533230
78CDK70.77075510
79MINK10.75142861
80MTOR0.74164107
81BRAF0.74106405
82NME10.71461404
83DYRK20.71273960
84NEK90.71236872
85TAOK20.70914723
86PLK30.70478223
87LATS20.68980907
88BCKDK0.68915940
89NME20.67051929
90MAP2K30.66373506
91KSR20.65709196
92EIF2AK10.64748935
93SIK30.62496388
94SIK20.61777182
95CDK20.61167976
96OBSCN0.60841060
97CHEK20.60754620
98MELK0.58454591
99MAP4K20.56513623
100PAK20.55881217
101VRK10.54988712
102AKT20.54798000
103BMX0.54095333
104ICK0.53970012
105KDR0.53693397
106CSNK1E0.53677035
107CSNK2A20.53283802
108CDK80.52928346
109AURKA0.51618943
110MAP3K50.51548175
111MARK10.51323436
112CDK60.50960714
113PRKDC0.50167536
114ZAP700.49952880
115FGFR40.49760035
116DYRK1B0.49574690
117TYRO30.49504054
118ERBB30.49063639
119STK40.48563985
120RET0.44236714
121CDK10.42628899
122TIE10.42004756
123TAOK10.40781001
124BRD40.40209924
125PIM10.38986765
126BTK0.37510253
127RPS6KA10.36667601
128MAPK110.36469715
129ATM0.36318070
130KIT0.35108121
131PAK10.34813968
132MAP3K70.33274084
133JAK30.30368535
134RIPK10.29824944
135CSF1R0.28222473
136UHMK10.26960405
137MAPK90.26475828
138PRKCI0.25397249
139RAF10.24320755
140PRKD30.24314865

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.53967445
2Mismatch repair_Homo sapiens_hsa034303.67880949
3Spliceosome_Homo sapiens_hsa030403.03364664
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.87091938
5Base excision repair_Homo sapiens_hsa034102.82637386
6Cell cycle_Homo sapiens_hsa041102.73510736
7RNA transport_Homo sapiens_hsa030132.62715503
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.29239109
9Nucleotide excision repair_Homo sapiens_hsa034202.15977465
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.07553206
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.03607222
12Homologous recombination_Homo sapiens_hsa034402.03226723
13mRNA surveillance pathway_Homo sapiens_hsa030151.85134573
14Proteasome_Homo sapiens_hsa030501.74459391
15One carbon pool by folate_Homo sapiens_hsa006701.64010792
16RNA degradation_Homo sapiens_hsa030181.58403256
17Ribosome_Homo sapiens_hsa030101.55345001
18RNA polymerase_Homo sapiens_hsa030201.47938092
19Pyrimidine metabolism_Homo sapiens_hsa002401.46727081
20Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.45520284
21Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.43626416
22Colorectal cancer_Homo sapiens_hsa052101.38718131
23p53 signaling pathway_Homo sapiens_hsa041151.37381594
24Oocyte meiosis_Homo sapiens_hsa041141.30501211
25Viral myocarditis_Homo sapiens_hsa054161.26444648
26Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.25219343
27Chronic myeloid leukemia_Homo sapiens_hsa052201.22834038
28HTLV-I infection_Homo sapiens_hsa051661.21981325
29Central carbon metabolism in cancer_Homo sapiens_hsa052301.21915806
30Viral carcinogenesis_Homo sapiens_hsa052031.21530560
31Biosynthesis of amino acids_Homo sapiens_hsa012301.20083383
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.18634036
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.18619153
34Notch signaling pathway_Homo sapiens_hsa043301.17715776
35Epstein-Barr virus infection_Homo sapiens_hsa051691.14812322
36Fanconi anemia pathway_Homo sapiens_hsa034601.13718343
37Carbon metabolism_Homo sapiens_hsa012001.11474048
38Fatty acid elongation_Homo sapiens_hsa000621.11410511
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.08510634
40Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.05625219
41Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.04985311
42Small cell lung cancer_Homo sapiens_hsa052221.02614738
43mTOR signaling pathway_Homo sapiens_hsa041501.01606600
44Basal transcription factors_Homo sapiens_hsa030220.99927800
45MicroRNAs in cancer_Homo sapiens_hsa052060.98876973
46Thyroid cancer_Homo sapiens_hsa052160.98559299
47Non-homologous end-joining_Homo sapiens_hsa034500.98276296
48Basal cell carcinoma_Homo sapiens_hsa052170.93767177
49Hippo signaling pathway_Homo sapiens_hsa043900.91448167
50Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.91112356
51Fructose and mannose metabolism_Homo sapiens_hsa000510.90143926
52Endometrial cancer_Homo sapiens_hsa052130.89449779
53Non-small cell lung cancer_Homo sapiens_hsa052230.88757944
54Antigen processing and presentation_Homo sapiens_hsa046120.87181635
55Pancreatic cancer_Homo sapiens_hsa052120.85435798
56Systemic lupus erythematosus_Homo sapiens_hsa053220.84505372
57Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.82391185
58Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80433316
59HIF-1 signaling pathway_Homo sapiens_hsa040660.79351239
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76484841
61Purine metabolism_Homo sapiens_hsa002300.75893574
62Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.75783944
63Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.75201142
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.74574445
65Fatty acid metabolism_Homo sapiens_hsa012120.73819457
66Acute myeloid leukemia_Homo sapiens_hsa052210.73575911
67Insulin signaling pathway_Homo sapiens_hsa049100.73007688
68Pentose phosphate pathway_Homo sapiens_hsa000300.72783328
69Herpes simplex infection_Homo sapiens_hsa051680.71149347
70Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.70485883
71VEGF signaling pathway_Homo sapiens_hsa043700.70152190
72N-Glycan biosynthesis_Homo sapiens_hsa005100.69916505
73Propanoate metabolism_Homo sapiens_hsa006400.69460559
74Shigellosis_Homo sapiens_hsa051310.68577038
75Parkinsons disease_Homo sapiens_hsa050120.68303731
76Dilated cardiomyopathy_Homo sapiens_hsa054140.68232212
77Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.68100476
78Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.65509358
79Bladder cancer_Homo sapiens_hsa052190.65490612
80Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65015533
81Apoptosis_Homo sapiens_hsa042100.64727328
82AMPK signaling pathway_Homo sapiens_hsa041520.64682813
83Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63708353
84Proteoglycans in cancer_Homo sapiens_hsa052050.62408298
85Huntingtons disease_Homo sapiens_hsa050160.62122145
86Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.60180047
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59793321
88Protein export_Homo sapiens_hsa030600.59305443
89Alcoholism_Homo sapiens_hsa050340.57457644
90Primary immunodeficiency_Homo sapiens_hsa053400.56751433
91Hepatitis B_Homo sapiens_hsa051610.56745549
92Adherens junction_Homo sapiens_hsa045200.56508936
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.56318152
94Arginine and proline metabolism_Homo sapiens_hsa003300.55890172
95Pathways in cancer_Homo sapiens_hsa052000.55265838
96Legionellosis_Homo sapiens_hsa051340.53322329
97T cell receptor signaling pathway_Homo sapiens_hsa046600.52557887
98Focal adhesion_Homo sapiens_hsa045100.52164914
99Sulfur relay system_Homo sapiens_hsa041220.52101236
100Insulin resistance_Homo sapiens_hsa049310.50948224
101Lysine degradation_Homo sapiens_hsa003100.50923777
102Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49656880
103Hedgehog signaling pathway_Homo sapiens_hsa043400.49575236
104Steroid biosynthesis_Homo sapiens_hsa001000.47156847
105Glucagon signaling pathway_Homo sapiens_hsa049220.47155993
106Galactose metabolism_Homo sapiens_hsa000520.46035560
107Cysteine and methionine metabolism_Homo sapiens_hsa002700.45853455
108Pyruvate metabolism_Homo sapiens_hsa006200.45832915
109Platelet activation_Homo sapiens_hsa046110.45271403
110AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45200007
111Renal cell carcinoma_Homo sapiens_hsa052110.45035400
112B cell receptor signaling pathway_Homo sapiens_hsa046620.44195909
113Vibrio cholerae infection_Homo sapiens_hsa051100.43000798
114Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41852728
115Tight junction_Homo sapiens_hsa045300.40907001
116FoxO signaling pathway_Homo sapiens_hsa040680.40820340
117Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40439810
118Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39921546
119Leukocyte transendothelial migration_Homo sapiens_hsa046700.38298013
120Synaptic vesicle cycle_Homo sapiens_hsa047210.38248940
121Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.37994382
122TGF-beta signaling pathway_Homo sapiens_hsa043500.37939634
123Toxoplasmosis_Homo sapiens_hsa051450.37878197
124Wnt signaling pathway_Homo sapiens_hsa043100.37569484
125Glioma_Homo sapiens_hsa052140.35694249
126Folate biosynthesis_Homo sapiens_hsa007900.30212869
127Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.29368084
128Glutathione metabolism_Homo sapiens_hsa004800.28052003
129Cardiac muscle contraction_Homo sapiens_hsa042600.26555776
130Arginine biosynthesis_Homo sapiens_hsa002200.26086297
131Prostate cancer_Homo sapiens_hsa052150.25623920
132Gap junction_Homo sapiens_hsa045400.25049297
133Inositol phosphate metabolism_Homo sapiens_hsa005620.24972408
134Endocytosis_Homo sapiens_hsa041440.24894143
135ErbB signaling pathway_Homo sapiens_hsa040120.24224320

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