NAP1L4P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.28392630
2regulation of B cell receptor signaling pathway (GO:0050855)5.17930680
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.10158751
4positive regulation by organism of defense response of other organism involved in symbiotic interact5.10158751
5modulation by symbiont of host immune response (GO:0052553)5.10158751
6positive regulation by symbiont of host defense response (GO:0052509)5.10158751
7modulation by symbiont of host defense response (GO:0052031)5.10158751
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.10158751
9detection of molecule of bacterial origin (GO:0032490)5.09939551
10positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.86707957
11response to peptidoglycan (GO:0032494)4.74770864
12cellular extravasation (GO:0045123)4.44931823
13regulation of gamma-delta T cell activation (GO:0046643)4.34692474
14positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.30301879
15NIK/NF-kappaB signaling (GO:0038061)4.20126511
16negative regulation of interleukin-12 production (GO:0032695)4.07235245
17macrophage activation involved in immune response (GO:0002281)4.01300953
18B cell receptor signaling pathway (GO:0050853)4.01248701
19response to muramyl dipeptide (GO:0032495)3.96666393
20regulation of gamma-delta T cell differentiation (GO:0045586)3.85671882
21regulation of interferon-beta biosynthetic process (GO:0045357)3.77171375
22positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.74899715
23regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.72284296
24neutrophil mediated immunity (GO:0002446)3.71641005
25negative regulation of cell killing (GO:0031342)3.65667743
26negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.65667743
27detection of external biotic stimulus (GO:0098581)3.63132541
28response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.58615100
29response to host immune response (GO:0052572)3.58615100
30microglial cell activation (GO:0001774)3.55288275
31germinal center formation (GO:0002467)3.52309263
32T-helper 1 type immune response (GO:0042088)3.50495733
33positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.50433937
34negative thymic T cell selection (GO:0045060)3.50397702
35detection of biotic stimulus (GO:0009595)3.41127835
36response to host (GO:0075136)3.39668539
37response to host defenses (GO:0052200)3.39668539
38response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.39668539
39negative T cell selection (GO:0043383)3.38006434
40antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.37167583
41detection of other organism (GO:0098543)3.36752395
42myeloid cell activation involved in immune response (GO:0002275)3.36518512
43macrophage activation (GO:0042116)3.36082569
44neutrophil activation involved in immune response (GO:0002283)3.35378836
45positive regulation of interferon-alpha production (GO:0032727)3.34125481
46T cell migration (GO:0072678)3.31937828
47lipopolysaccharide-mediated signaling pathway (GO:0031663)3.28724783
48positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.26078069
49cell wall macromolecule catabolic process (GO:0016998)3.25732290
50positive regulation of B cell differentiation (GO:0045579)3.24183731
51regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.21855525
52interferon-gamma production (GO:0032609)3.19618080
53regulation of interleukin-12 biosynthetic process (GO:0045075)3.16920673
54regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.16136004
55I-kappaB phosphorylation (GO:0007252)3.15391398
56regulation of interferon-alpha production (GO:0032647)3.13126173
57myeloid leukocyte mediated immunity (GO:0002444)3.12766836
58positive thymic T cell selection (GO:0045059)3.08454495
59response to interleukin-15 (GO:0070672)3.07241440
60positive regulation of interferon-beta production (GO:0032728)3.03938835
61defense response to protozoan (GO:0042832)3.03446351
62regulation of B cell differentiation (GO:0045577)3.03267829
63hepatocyte apoptotic process (GO:0097284)3.02488367
64negative regulation of T cell mediated immunity (GO:0002710)3.01091154
65cellular response to ethanol (GO:0071361)2.99508215
66dosage compensation (GO:0007549)2.98967308
67response to protozoan (GO:0001562)2.97272061
68pinocytosis (GO:0006907)2.97052655
69neutrophil activation (GO:0042119)2.91596506
70negative regulation of lymphocyte mediated immunity (GO:0002707)2.91583338
71negative regulation of toll-like receptor signaling pathway (GO:0034122)2.90963018
72antigen processing and presentation of endogenous antigen (GO:0019883)2.89718680
73antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.89154901
74regulation of necroptotic process (GO:0060544)2.88639897
75B cell homeostasis (GO:0001782)2.86780094
76respiratory burst (GO:0045730)2.85788225
77regulation of interleukin-8 biosynthetic process (GO:0045414)2.85308470
78CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.83917638
79myeloid leukocyte activation (GO:0002274)2.77281653
80detection of bacterium (GO:0016045)2.77102582
81myeloid dendritic cell activation (GO:0001773)2.75904372
82regulation of interferon-beta production (GO:0032648)2.75705958
83granulocyte activation (GO:0036230)2.73717705
84positive T cell selection (GO:0043368)2.73218020
85negative regulation of erythrocyte differentiation (GO:0045647)2.70138933
86leukocyte degranulation (GO:0043299)2.70040317
87negative regulation of B cell proliferation (GO:0030889)2.69599462
88regulation of macrophage cytokine production (GO:0010935)2.69369457
89antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.68170507
90immunoglobulin mediated immune response (GO:0016064)2.67107607
91positive regulation of cellular amide metabolic process (GO:0034250)2.66536891
92positive regulation of macrophage cytokine production (GO:0060907)2.66239013
93regulation of B cell proliferation (GO:0030888)2.66153958
94mast cell activation (GO:0045576)2.64690250
95positive regulation of granulocyte differentiation (GO:0030854)2.64129104
96negative regulation of myeloid cell apoptotic process (GO:0033033)2.63238077
97regulation of alpha-beta T cell proliferation (GO:0046640)2.62422778
98regulation of toll-like receptor signaling pathway (GO:0034121)2.59370445
99regulation of mast cell degranulation (GO:0043304)2.58618703
100embryonic process involved in female pregnancy (GO:0060136)2.57625695

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.73183002
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.34803964
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.76850484
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.55497791
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.54272138
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.35833121
7MYB_21317192_ChIP-Seq_ERMYB_Mouse3.27611045
8IRF8_21731497_ChIP-ChIP_J774_Mouse3.25085404
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.09514267
10IRF8_27001747_Chip-Seq_BMDM_Mouse2.94843070
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.90664240
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.87409142
13RUNX_20019798_ChIP-Seq_JUKART_Human2.76296377
14MYC_22102868_ChIP-Seq_BL_Human2.74708007
15SCL_19346495_ChIP-Seq_HPC-7_Human2.67077403
16MYB_26560356_Chip-Seq_TH2_Human2.60913003
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.58655530
18SPI1_23547873_ChIP-Seq_NB4_Human2.53856975
19STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.44430204
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.41449666
21Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.36219413
22VDR_24763502_ChIP-Seq_THP-1_Human2.35215806
23MYB_26560356_Chip-Seq_TH1_Human2.34106140
24VDR_21846776_ChIP-Seq_THP-1_Human2.33275481
25BP1_19119308_ChIP-ChIP_Hs578T_Human2.31048955
26STAT4_19710469_ChIP-ChIP_TH1__Mouse2.29453061
27BRD4_27068464_Chip-Seq_AML-cells_Mouse2.23960095
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.20406066
29GATA1_22025678_ChIP-Seq_K562_Human2.19696618
30MAF_26560356_Chip-Seq_TH1_Human2.15231813
31RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.11333068
32FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.10495169
33SPI1_23127762_ChIP-Seq_K562_Human2.06141974
34VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.04254270
35SMAD_19615063_ChIP-ChIP_OVARY_Human1.93695279
36NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.93082628
37E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.84517364
38RUNX1_22412390_ChIP-Seq_EML_Mouse1.84250910
39TCF7_22412390_ChIP-Seq_EML_Mouse1.83745434
40ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.82914661
41NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.77121280
42GATA3_27048872_Chip-Seq_THYMUS_Human1.76470062
43TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.76058634
44VDR_24787735_ChIP-Seq_THP-1_Human1.73595132
45UTX_26944678_Chip-Seq_JUKART_Human1.73009918
46E2F7_22180533_ChIP-Seq_HELA_Human1.71997621
47RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.71678070
48GATA2_22383799_ChIP-Seq_G1ME_Mouse1.60058699
49PU_27001747_Chip-Seq_BMDM_Mouse1.59585210
50GATA1_19941826_ChIP-Seq_K562_Human1.57279706
51SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.51256479
52GATA1_19941827_ChIP-Seq_MEL_Mouse1.49246750
53GATA2_19941826_ChIP-Seq_K562_Human1.48114529
54PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.48022642
55KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.45530324
56SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.38047700
57GATA3_26560356_Chip-Seq_TH2_Human1.37129555
58MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.37109498
59CIITA_25753668_ChIP-Seq_RAJI_Human1.35392844
60KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.32742207
61NCOR1_26117541_ChIP-Seq_K562_Human1.30850388
62MAF_26560356_Chip-Seq_TH2_Human1.30023170
63NOTCH1_21737748_ChIP-Seq_TLL_Human1.22731502
64GATA1_22383799_ChIP-Seq_G1ME_Mouse1.22591651
65KDM2B_26808549_Chip-Seq_SUP-B15_Human1.20408500
66FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.19788714
67PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19302560
68GATA2_21666600_ChIP-Seq_HMVEC_Human1.15770851
69GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14337061
70CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12494295
71TFEB_21752829_ChIP-Seq_HELA_Human1.10392785
72LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.09976927
73TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.06220939
74CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03856321
75KDM2B_26808549_Chip-Seq_DND41_Human1.03337733
76BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.02088650
77PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01029139
78CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.00156661
79PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99232323
80CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96793296
81CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95654301
82FOXM1_23109430_ChIP-Seq_U2OS_Human0.92564983
83LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.88878345
84STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.88043635
85GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.87933294
86SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85993060
87FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.85854055
88FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.85213751
89HOXB4_20404135_ChIP-ChIP_EML_Mouse0.84129115
90LXR_22158963_ChIP-Seq_LIVER_Mouse0.83750838
91RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83731030
92SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83302779
93CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.82740530
94GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.81564196
95ELF1_17652178_ChIP-ChIP_JURKAT_Human0.79625289
96PPARA_22158963_ChIP-Seq_LIVER_Mouse0.79444383
97GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79430438
98FOXO3_23340844_ChIP-Seq_DLD1_Human0.78849657
99RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.77979704
100ERG_20887958_ChIP-Seq_HPC-7_Mouse0.76792205

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation3.69895228
2MP0001835_abnormal_antigen_presentation3.42244169
3MP0000685_abnormal_immune_system3.06265921
4MP0003436_decreased_susceptibility_to3.01951122
5MP0003656_abnormal_erythrocyte_physiolo2.85125260
6MP0003724_increased_susceptibility_to2.74185097
7MP0001800_abnormal_humoral_immune2.74104380
8MP0002419_abnormal_innate_immunity2.63882347
9MP0005000_abnormal_immune_tolerance2.59042858
10MP0008057_abnormal_DNA_replication2.56791082
11MP0008260_abnormal_autophagy2.50067819
12MP0005671_abnormal_response_to2.46715112
13MP0002723_abnormal_immune_serum2.39081580
14MP0002452_abnormal_antigen_presenting2.36059327
15MP0002396_abnormal_hematopoietic_system2.35336306
16MP0005025_abnormal_response_to2.33212151
17MP0002420_abnormal_adaptive_immunity2.27356298
18MP0001819_abnormal_immune_cell2.24460688
19MP0001790_abnormal_immune_system2.22729708
20MP0005387_immune_system_phenotype2.22729708
21MP0005451_abnormal_body_composition2.21257330
22MP0002166_altered_tumor_susceptibility2.16988746
23MP0005464_abnormal_platelet_physiology2.16963826
24MP0009785_altered_susceptibility_to2.15866814
25MP0003763_abnormal_thymus_physiology2.14915798
26MP0002398_abnormal_bone_marrow2.03727812
27MP0003172_abnormal_lysosome_physiology2.03712660
28MP0000569_abnormal_digit_pigmentation1.99968704
29MP0000716_abnormal_immune_system1.87581043
30MP0002405_respiratory_system_inflammati1.86871510
31MP0004947_skin_inflammation1.84103239
32MP0001853_heart_inflammation1.83473652
33MP0002148_abnormal_hypersensitivity_rea1.83408620
34MP0002006_tumorigenesis1.71973688
35MP0000689_abnormal_spleen_morphology1.69949056
36MP0002722_abnormal_immune_system1.69228028
37MP0001545_abnormal_hematopoietic_system1.65699124
38MP0005397_hematopoietic_system_phenotyp1.65699124
39MP0005076_abnormal_cell_differentiation1.65336432
40MP0002429_abnormal_blood_cell1.60966188
41MP0006082_CNS_inflammation1.59214705
42MP0000858_altered_metastatic_potential1.58041396
43MP0009278_abnormal_bone_marrow1.57883250
44MP0001845_abnormal_inflammatory_respons1.55790942
45MP0004381_abnormal_hair_follicle1.53001073
46MP0003300_gastrointestinal_ulcer1.52091963
47MP0003828_pulmonary_edema1.48100517
48MP0009333_abnormal_splenocyte_physiolog1.46706785
49MP0004808_abnormal_hematopoietic_stem1.46559801
50MP0002132_abnormal_respiratory_system1.43902120
51MP0010155_abnormal_intestine_physiology1.39318067
52MP0009764_decreased_sensitivity_to1.35170622
53MP0000703_abnormal_thymus_morphology1.34814671
54MP0004510_myositis1.31957268
55MP0005310_abnormal_salivary_gland1.28072966
56MP0001533_abnormal_skeleton_physiology1.27051687
57MP0002998_abnormal_bone_remodeling1.26750913
58MP0004883_abnormal_blood_vessel1.24943704
59MP0003221_abnormal_cardiomyocyte_apopto1.22786525
60MP0008469_abnormal_protein_level1.19705411
61MP0005164_abnormal_response_to1.11064426
62MP0003866_abnormal_defecation1.10857288
63MP0010352_gastrointestinal_tract_polyps1.05447970
64MP0002009_preneoplasia1.04865382
65MP0000371_diluted_coat_color1.03999131
66MP0003091_abnormal_cell_migration1.03103611
67MP0002332_abnormal_exercise_endurance1.02810079
68MP0005058_abnormal_lysosome_morphology1.01374658
69MP0002877_abnormal_melanocyte_morpholog1.01193031
70MP0002138_abnormal_hepatobiliary_system1.01047151
71MP0003191_abnormal_cellular_cholesterol0.99027799
72MP0003075_altered_response_to0.95843624
73MP0009763_increased_sensitivity_to0.95701881
74MP0001851_eye_inflammation0.94767273
75MP0002019_abnormal_tumor_incidence0.94459976
76MP0000609_abnormal_liver_physiology0.93529389
77MP0006054_spinal_hemorrhage0.92356270
78MP0005167_abnormal_blood-brain_barrier0.89808438
79MP0005621_abnormal_cell_physiology0.82801245
80MP0000015_abnormal_ear_pigmentation0.81422015
81MP0003252_abnormal_bile_duct0.78602627
82MP0003950_abnormal_plasma_membrane0.75868649
83MP0005075_abnormal_melanosome_morpholog0.75795465
84MP0009765_abnormal_xenobiotic_induced0.74773349
85MP0003045_fibrosis0.73224494
86MP0003183_abnormal_peptide_metabolism0.72534973
87MP0000604_amyloidosis0.71686267
88MP0001915_intracranial_hemorrhage0.70927601
89MP0005408_hypopigmentation0.70387934
90MP0010307_abnormal_tumor_latency0.68913341
91MP0000249_abnormal_blood_vessel0.68810589
92MP0003448_altered_tumor_morphology0.67443025
93MP0009115_abnormal_fat_cell0.66146876
94MP0002139_abnormal_hepatobiliary_system0.63061469
95MP0004147_increased_porphyrin_level0.63033942
96MP0005384_cellular_phenotype0.62956025
97MP0003453_abnormal_keratinocyte_physiol0.61156776
98MP0003195_calcinosis0.61074138
99MP0000465_gastrointestinal_hemorrhage0.60682720
100MP0003690_abnormal_glial_cell0.59343109

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)4.83943411
2Retrobulbar optic neuritis (HP:0100654)4.56569094
3Optic neuritis (HP:0100653)4.56569094
4Recurrent abscess formation (HP:0002722)4.33283192
5Orchitis (HP:0100796)4.30379115
6Myositis (HP:0100614)4.08932797
7Abnormal delayed hypersensitivity skin test (HP:0002963)3.93523608
8Eczematoid dermatitis (HP:0000976)3.89143716
9Abnormality of macrophages (HP:0004311)3.79515197
10Mediastinal lymphadenopathy (HP:0100721)3.73580908
11Keratoconjunctivitis sicca (HP:0001097)3.72482691
12Recurrent fungal infections (HP:0002841)3.72193057
13Gastrointestinal infarctions (HP:0005244)3.71782153
14Recurrent viral infections (HP:0004429)3.70555821
15Meningitis (HP:0001287)3.60641724
16Recurrent gram-negative bacterial infections (HP:0005420)3.59033228
17Colitis (HP:0002583)3.55133987
18Recurrent cutaneous fungal infections (HP:0011370)3.53384259
19Chronic mucocutaneous candidiasis (HP:0002728)3.53384259
20Vasculitis (HP:0002633)3.53258157
21Recurrent skin infections (HP:0001581)3.49411753
22Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.45488252
23Arterial thrombosis (HP:0004420)3.34125812
24Keratoconjunctivitis (HP:0001096)3.32501313
25Elevated erythrocyte sedimentation rate (HP:0003565)3.25603334
26Gingival bleeding (HP:0000225)3.21471668
27Autoimmune hemolytic anemia (HP:0001890)3.19165089
28Viral hepatitis (HP:0006562)3.17246581
29Agammaglobulinemia (HP:0004432)3.11641121
30Encephalitis (HP:0002383)3.04483524
31Abnormality of T cell number (HP:0011839)3.01449107
32T lymphocytopenia (HP:0005403)3.00637173
33Fatigue (HP:0012378)2.95235196
34Stomatitis (HP:0010280)2.91977387
35Abnormality of T cells (HP:0002843)2.90023274
36Cellulitis (HP:0100658)2.89464664
37Abnormality of T cell physiology (HP:0011840)2.87409944
38Inflammation of the large intestine (HP:0002037)2.82556034
39Pulmonary infiltrates (HP:0002113)2.81571877
40Abnormality of the peritoneum (HP:0002585)2.76069116
41Chronic obstructive pulmonary disease (HP:0006510)2.74554767
42Obstructive lung disease (HP:0006536)2.74554767
43Gastrointestinal inflammation (HP:0004386)2.74135136
44Deep venous thrombosis (HP:0002625)2.73196515
45Autoimmune thrombocytopenia (HP:0001973)2.70665829
46IgA deficiency (HP:0002720)2.67134272
47Epistaxis (HP:0000421)2.64512722
48Panhypogammaglobulinemia (HP:0003139)2.63746670
49Granulocytopenia (HP:0001913)2.62253235
50Gangrene (HP:0100758)2.60407318
51Myocardial infarction (HP:0001658)2.55828240
52Chest pain (HP:0100749)2.53220653
53Gingivitis (HP:0000230)2.49028134
54Spontaneous hematomas (HP:0007420)2.48739183
55Leukocytosis (HP:0001974)2.46418760
56Urticaria (HP:0001025)2.46386411
57Amyloidosis (HP:0011034)2.45380344
58Subacute progressive viral hepatitis (HP:0006572)2.44842576
59Episodic fever (HP:0001954)2.44092801
60Pustule (HP:0200039)2.41507166
61Prolonged bleeding time (HP:0003010)2.41390988
62Peritonitis (HP:0002586)2.40993816
63Thrombophlebitis (HP:0004418)2.40222934
64Abnormality of the common coagulation pathway (HP:0010990)2.39897593
65Osteomyelitis (HP:0002754)2.36001151
66Hemoptysis (HP:0002105)2.35613426
67Slow saccadic eye movements (HP:0000514)2.34978091
68Acute hepatic failure (HP:0006554)2.31988772
69Pulmonary embolism (HP:0002204)2.30309316
70Glomerulopathy (HP:0100820)2.26596938
71Lymphopenia (HP:0001888)2.21351408
72Poikilocytosis (HP:0004447)2.19863730
73Abnormality of cells of the lymphoid lineage (HP:0012140)2.18648370
74Abnormality of the pleura (HP:0002103)2.15799803
75Abnormality of the fingertips (HP:0001211)2.15553786
76Anorexia (HP:0002039)2.15003879
77Eosinophilia (HP:0001880)2.12653713
78Somatic mutation (HP:0001428)2.09976826
79Gastrointestinal stroma tumor (HP:0100723)2.09433365
80Recurrent bronchitis (HP:0002837)2.08442799
81Thrombocytosis (HP:0001894)2.08269996
82Increased serum ferritin (HP:0003281)2.04040030
83Acanthocytosis (HP:0001927)2.00834839
84IgM deficiency (HP:0002850)1.99976666
85Chronic diarrhea (HP:0002028)1.99540490
86Increased IgE level (HP:0003212)1.99519276
87Abnormal platelet function (HP:0011869)1.98865994
88Impaired platelet aggregation (HP:0003540)1.98865994
89IgG deficiency (HP:0004315)1.98657427
90Sepsis (HP:0100806)1.97562192
91Keratitis (HP:0000491)1.94444149
92Menorrhagia (HP:0000132)1.94305227
93Abnormality of the endocardium (HP:0004306)1.93099263
94Recurrent sinusitis (HP:0011108)1.91742773
95Skin ulcer (HP:0200042)1.86343444
96Submucous cleft hard palate (HP:0000176)1.85507250
97Amaurosis fugax (HP:0100576)1.84517181
98Hepatitis (HP:0012115)1.83848680
99Arthralgia (HP:0002829)1.83822572
100Periodontitis (HP:0000704)1.83429847

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.59373579
2TXK3.48896822
3MAP3K142.96810825
4IKBKE2.81273393
5PRPF4B2.73326243
6IRAK42.70305715
7CDK122.39000268
8BLK2.33060705
9IRAK32.29362053
10MAP4K12.28618094
11BMPR22.17257440
12MAP2K32.04069930
13TYK21.83914170
14CSK1.79945320
15SYK1.78523737
16IRAK11.66232709
17WNK11.64041829
18FGFR31.63700343
19FGR1.60208206
20IRAK21.52833712
21STK101.51508074
22JAK11.50037202
23TBK11.49147049
24ZAP701.47950486
25TAOK31.43100791
26TGFBR21.38402539
27MATK1.38073262
28JAK31.37410817
29BTK1.34779580
30MAP3K131.34691040
31FGFR41.33732830
32SIK21.33493458
33IKBKB1.31200006
34GRK61.30448677
35JAK21.21482627
36GRK71.17525243
37HCK1.16282148
38MOS1.11902447
39LYN1.11453187
40ITK1.10224890
41CSF1R1.10202819
42PIK3CG1.05997237
43RAF11.04522982
44MAP3K21.04336831
45KIT1.04296852
46TRPM71.02200620
47CHUK1.01771510
48PDK11.00380400
49KSR20.94094974
50FES0.93217646
51TESK20.91931620
52PIM10.90366214
53LCK0.89793058
54ERN10.89490915
55TEC0.88938187
56NEK90.88047242
57MAPK110.81953635
58STK240.81491535
59YES10.78146246
60MARK30.77828068
61EIF2AK10.76751693
62CDK40.76710668
63MAP3K10.74282618
64BRD40.73282991
65TAOK20.72735915
66CAMK1D0.71537316
67MAP3K60.68871620
68PDPK10.67151839
69CDC42BPA0.65707120
70RPS6KB20.64656800
71PRKCQ0.62523300
72MAP3K50.60181543
73MELK0.58484705
74SGK30.52970290
75SGK20.52396125
76EIF2AK30.50150425
77PIK3CA0.48064498
78RET0.47908862
79STK40.46926024
80ACVR1B0.46759377
81TRIB30.46624484
82CAMKK20.46513207
83SIK30.44947734
84PDK20.41413394
85MAPK120.40610962
86MAP3K30.40592662
87CDK60.39093818
88HIPK20.37795135
89GRK50.36407595
90MARK20.36285082
91MAP3K80.35437349
92ARAF0.34939546
93MAPKAPK20.34639030
94SGK10.34449499
95LRRK20.34350777
96MAPK70.33474193
97STK160.30347103
98AKT30.29949220
99EGFR0.29888412
100EIF2AK20.29762925

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.81109240
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.69849560
3B cell receptor signaling pathway_Homo sapiens_hsa046622.67954610
4Toll-like receptor signaling pathway_Homo sapiens_hsa046202.42026126
5Osteoclast differentiation_Homo sapiens_hsa043802.39724858
6NOD-like receptor signaling pathway_Homo sapiens_hsa046212.20296756
7RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.13714817
8Measles_Homo sapiens_hsa051622.05373864
9Staphylococcus aureus infection_Homo sapiens_hsa051502.01698150
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.97538948
11Primary immunodeficiency_Homo sapiens_hsa053401.89399369
12Graft-versus-host disease_Homo sapiens_hsa053321.86417037
13Tuberculosis_Homo sapiens_hsa051521.84017352
14TNF signaling pathway_Homo sapiens_hsa046681.82061241
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.81776255
16Influenza A_Homo sapiens_hsa051641.81774809
17Allograft rejection_Homo sapiens_hsa053301.81137474
18Non-small cell lung cancer_Homo sapiens_hsa052231.79446223
19Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.75486837
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.74213483
21Hepatitis B_Homo sapiens_hsa051611.70218935
22Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.65959045
23T cell receptor signaling pathway_Homo sapiens_hsa046601.65919830
24Acute myeloid leukemia_Homo sapiens_hsa052211.64972170
25Legionellosis_Homo sapiens_hsa051341.62004650
26Toxoplasmosis_Homo sapiens_hsa051451.59675699
27Autoimmune thyroid disease_Homo sapiens_hsa053201.57587378
28Herpes simplex infection_Homo sapiens_hsa051681.55043688
29Pancreatic cancer_Homo sapiens_hsa052121.53081658
30Jak-STAT signaling pathway_Homo sapiens_hsa046301.49735687
31Malaria_Homo sapiens_hsa051441.44574416
32Antigen processing and presentation_Homo sapiens_hsa046121.42059268
33Hematopoietic cell lineage_Homo sapiens_hsa046401.41805388
34Other glycan degradation_Homo sapiens_hsa005111.41357084
35Chronic myeloid leukemia_Homo sapiens_hsa052201.38056464
36Apoptosis_Homo sapiens_hsa042101.35962466
37Hepatitis C_Homo sapiens_hsa051601.31530443
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.29882366
39Type I diabetes mellitus_Homo sapiens_hsa049401.29827583
40Chemokine signaling pathway_Homo sapiens_hsa040621.21160560
41Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.19187378
42Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.18268883
43Neurotrophin signaling pathway_Homo sapiens_hsa047221.15648428
44Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.13953741
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.12131162
46Epstein-Barr virus infection_Homo sapiens_hsa051691.09869968
47Asthma_Homo sapiens_hsa053101.09351582
48Prolactin signaling pathway_Homo sapiens_hsa049171.08863937
49Shigellosis_Homo sapiens_hsa051311.06091939
50VEGF signaling pathway_Homo sapiens_hsa043701.05467721
51Renal cell carcinoma_Homo sapiens_hsa052111.03244377
52Pertussis_Homo sapiens_hsa051331.01859341
53Complement and coagulation cascades_Homo sapiens_hsa046100.98578421
54HIF-1 signaling pathway_Homo sapiens_hsa040660.96497175
55Viral carcinogenesis_Homo sapiens_hsa052030.95446055
56Adipocytokine signaling pathway_Homo sapiens_hsa049200.94416925
57Viral myocarditis_Homo sapiens_hsa054160.94179594
58Platelet activation_Homo sapiens_hsa046110.92631813
59Leukocyte transendothelial migration_Homo sapiens_hsa046700.90854262
60mTOR signaling pathway_Homo sapiens_hsa041500.89237642
61Phosphatidylinositol signaling system_Homo sapiens_hsa040700.82383750
62Fatty acid biosynthesis_Homo sapiens_hsa000610.82311674
63Salmonella infection_Homo sapiens_hsa051320.81110550
64Insulin resistance_Homo sapiens_hsa049310.80258709
65Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78926162
66Small cell lung cancer_Homo sapiens_hsa052220.78811903
67Dorso-ventral axis formation_Homo sapiens_hsa043200.77417704
68Prostate cancer_Homo sapiens_hsa052150.75787168
69FoxO signaling pathway_Homo sapiens_hsa040680.75348415
70Type II diabetes mellitus_Homo sapiens_hsa049300.74587440
71Endometrial cancer_Homo sapiens_hsa052130.74443517
72Rheumatoid arthritis_Homo sapiens_hsa053230.73994467
73African trypanosomiasis_Homo sapiens_hsa051430.72045535
74ErbB signaling pathway_Homo sapiens_hsa040120.69935912
75Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.67418150
76Bladder cancer_Homo sapiens_hsa052190.66972296
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.65674170
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.62788750
79Inositol phosphate metabolism_Homo sapiens_hsa005620.62752410
80Phagosome_Homo sapiens_hsa041450.61467172
81Colorectal cancer_Homo sapiens_hsa052100.60886054
82HTLV-I infection_Homo sapiens_hsa051660.56314847
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54788011
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53640107
85MicroRNAs in cancer_Homo sapiens_hsa052060.52878045
86Glioma_Homo sapiens_hsa052140.49244792
87Choline metabolism in cancer_Homo sapiens_hsa052310.48360184
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48285201
89MAPK signaling pathway_Homo sapiens_hsa040100.46245627
90GnRH signaling pathway_Homo sapiens_hsa049120.46125782
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43995583
92Amoebiasis_Homo sapiens_hsa051460.43124707
93Lysosome_Homo sapiens_hsa041420.38854345
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38441832
95Proteoglycans in cancer_Homo sapiens_hsa052050.35706818
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35153414
97p53 signaling pathway_Homo sapiens_hsa041150.34249061
98Insulin signaling pathway_Homo sapiens_hsa049100.34028415
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.32927939
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32115490

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