NAP1L4P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.27084139
2establishment of protein localization to mitochondrial membrane (GO:0090151)5.23171803
3DNA deamination (GO:0045006)5.09627547
4behavioral response to nicotine (GO:0035095)4.60547502
5epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.37537756
6protein neddylation (GO:0045116)4.28945542
7regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.07049982
8somite development (GO:0061053)4.02470089
9water-soluble vitamin biosynthetic process (GO:0042364)4.00673637
10ribosomal large subunit biogenesis (GO:0042273)3.98024299
11ATP synthesis coupled proton transport (GO:0015986)3.95821885
12energy coupled proton transport, down electrochemical gradient (GO:0015985)3.95821885
13protein complex biogenesis (GO:0070271)3.88780911
14pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.83604121
15mitochondrial respiratory chain complex I assembly (GO:0032981)3.76562176
16NADH dehydrogenase complex assembly (GO:0010257)3.76562176
17mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.76562176
18nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.75833696
19ether lipid metabolic process (GO:0046485)3.71706934
20exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.71232539
21negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.70037059
22mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.62793249
23mitochondrial respiratory chain complex assembly (GO:0033108)3.62179293
24epithelial cilium movement (GO:0003351)3.60722720
25DNA double-strand break processing (GO:0000729)3.60261984
26mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.59056527
27viral transcription (GO:0019083)3.51370888
28translational termination (GO:0006415)3.49919099
29negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.39417155
30intraciliary transport (GO:0042073)3.38761407
31chromatin remodeling at centromere (GO:0031055)3.29886490
32pyrimidine nucleotide catabolic process (GO:0006244)3.28465443
33chaperone-mediated protein transport (GO:0072321)3.27707129
34maturation of 5.8S rRNA (GO:0000460)3.25056976
35SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.24239893
36kinetochore assembly (GO:0051382)3.22696440
37cotranslational protein targeting to membrane (GO:0006613)3.19298409
38myoblast migration (GO:0051451)3.19234516
39thalamus development (GO:0021794)3.15321264
40protein targeting to ER (GO:0045047)3.13497094
41axonemal dynein complex assembly (GO:0070286)3.11644757
42CENP-A containing nucleosome assembly (GO:0034080)3.10601762
43regulation of cilium movement (GO:0003352)3.09569948
44spliceosomal complex assembly (GO:0000245)3.08169470
45termination of RNA polymerase I transcription (GO:0006363)3.07480251
46establishment of protein localization to endoplasmic reticulum (GO:0072599)3.03545751
47maturation of SSU-rRNA (GO:0030490)3.03372857
48termination of RNA polymerase III transcription (GO:0006386)3.02974586
49transcription elongation from RNA polymerase III promoter (GO:0006385)3.02974586
50transcription elongation from RNA polymerase I promoter (GO:0006362)3.00344933
51kinetochore organization (GO:0051383)2.99293020
52histone exchange (GO:0043486)2.95656406
53protein localization to endoplasmic reticulum (GO:0070972)2.94893301
54translational elongation (GO:0006414)2.92513614
55ubiquinone biosynthetic process (GO:0006744)2.91332057
56rRNA methylation (GO:0031167)2.90173104
57DNA damage response, detection of DNA damage (GO:0042769)2.86211062
58electron transport chain (GO:0022900)2.85634895
59respiratory electron transport chain (GO:0022904)2.82435993
60negative regulation of DNA-templated transcription, elongation (GO:0032785)2.80483048
61substrate-independent telencephalic tangential migration (GO:0021826)2.79968035
62substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.79968035
63spliceosomal snRNP assembly (GO:0000387)2.79450084
64dopamine transport (GO:0015872)2.78381644
65cilium movement (GO:0003341)2.78115574
66translation (GO:0006412)2.77517872
67RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.76471509
68tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.76471509
69rRNA modification (GO:0000154)2.74682974
70replication fork processing (GO:0031297)2.74597300
71glycerol ether metabolic process (GO:0006662)2.73789184
72translational initiation (GO:0006413)2.73559484
73base-excision repair, AP site formation (GO:0006285)2.72942924
74cellular component biogenesis (GO:0044085)2.71567752
75ribosomal small subunit biogenesis (GO:0042274)2.71498120
76DNA replication-dependent nucleosome organization (GO:0034723)2.69323694
77DNA replication-dependent nucleosome assembly (GO:0006335)2.69323694
78ubiquinone metabolic process (GO:0006743)2.67967832
79pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.65476432
80organelle disassembly (GO:1903008)2.64395151
81protein peptidyl-prolyl isomerization (GO:0000413)2.64365783
82cellular protein complex disassembly (GO:0043624)2.63458615
83regulation of immunoglobulin secretion (GO:0051023)2.61838769
84ether metabolic process (GO:0018904)2.59655060
85pseudouridine synthesis (GO:0001522)2.59547118
86rRNA metabolic process (GO:0016072)2.58198456
87rRNA processing (GO:0006364)2.57820594
88somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.57803757
89isotype switching (GO:0045190)2.57803757
90somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.57803757
91sequestering of actin monomers (GO:0042989)2.57311266
92negative regulation of telomere maintenance (GO:0032205)2.54822020
93dentate gyrus development (GO:0021542)2.54782796
94negative regulation of alpha-beta T cell differentiation (GO:0046639)2.53417904
95preassembly of GPI anchor in ER membrane (GO:0016254)2.53383126
96ribosome assembly (GO:0042255)2.52378384
97protein polyglutamylation (GO:0018095)2.51950901
98peptidyl-histidine modification (GO:0018202)2.50341494
99regulation of mitotic spindle checkpoint (GO:1903504)2.49622349
100regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.49622349

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human4.42379850
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.65730505
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.38098587
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.34052157
5VDR_22108803_ChIP-Seq_LS180_Human3.07307254
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.04441225
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.02370752
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.86100437
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.71656734
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.45691563
11VDR_23849224_ChIP-Seq_CD4+_Human2.36609066
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.30390074
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.29364896
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.28157369
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.27525386
16ZNF274_21170338_ChIP-Seq_K562_Hela2.26479367
17ELK1_19687146_ChIP-ChIP_HELA_Human2.23268009
18EZH2_22144423_ChIP-Seq_EOC_Human2.22439321
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.21391256
20EWS_26573619_Chip-Seq_HEK293_Human2.21175060
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.16925904
22NOTCH1_21737748_ChIP-Seq_TLL_Human2.14819398
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.09899901
24E2F4_17652178_ChIP-ChIP_JURKAT_Human2.09692075
25FOXP3_21729870_ChIP-Seq_TREG_Human2.00388511
26MYC_18940864_ChIP-ChIP_HL60_Human1.93235557
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.88270310
28IRF1_19129219_ChIP-ChIP_H3396_Human1.87080458
29IGF1R_20145208_ChIP-Seq_DFB_Human1.86301858
30FUS_26573619_Chip-Seq_HEK293_Human1.86288217
31MYC_18555785_ChIP-Seq_MESCs_Mouse1.82582747
32CREB1_15753290_ChIP-ChIP_HEK293T_Human1.70909651
33POU5F1_16153702_ChIP-ChIP_HESCs_Human1.68776860
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.58405096
35CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.57605592
36PCGF2_27294783_Chip-Seq_NPCs_Mouse1.54042437
37TP53_22573176_ChIP-Seq_HFKS_Human1.51993803
38EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.50957119
39PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.49952825
40TTF2_22483619_ChIP-Seq_HELA_Human1.49393120
41POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.48808376
42PADI4_21655091_ChIP-ChIP_MCF-7_Human1.48239658
43P300_19829295_ChIP-Seq_ESCs_Human1.47657242
44MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.44257418
45ER_23166858_ChIP-Seq_MCF-7_Human1.43808075
46TAF15_26573619_Chip-Seq_HEK293_Human1.40535250
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.40468121
48SRF_21415370_ChIP-Seq_HL-1_Mouse1.38597379
49RBPJ_22232070_ChIP-Seq_NCS_Mouse1.36798478
50POU3F2_20337985_ChIP-ChIP_501MEL_Human1.35047675
51ZFP57_27257070_Chip-Seq_ESCs_Mouse1.31490700
52FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.30515827
53SOX2_18555785_ChIP-Seq_MESCs_Mouse1.28546862
54BCAT_22108803_ChIP-Seq_LS180_Human1.25445258
55MYC_19030024_ChIP-ChIP_MESCs_Mouse1.24016512
56NANOG_19829295_ChIP-Seq_ESCs_Human1.20832015
57SOX2_19829295_ChIP-Seq_ESCs_Human1.20832015
58SOX2_16153702_ChIP-ChIP_HESCs_Human1.20323521
59MYC_18358816_ChIP-ChIP_MESCs_Mouse1.19062601
60GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.17010131
61CTBP2_25329375_ChIP-Seq_LNCAP_Human1.15853791
62FOXA1_25329375_ChIP-Seq_VCAP_Human1.14492729
63FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14492729
64ERG_20517297_ChIP-Seq_VCAP_Human1.13861909
65TP63_19390658_ChIP-ChIP_HaCaT_Human1.09710620
66AR_20517297_ChIP-Seq_VCAP_Human1.09092309
67GATA3_21878914_ChIP-Seq_MCF-7_Human1.08436285
68DCP1A_22483619_ChIP-Seq_HELA_Human1.08242607
69PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07207323
70AUTS2_25519132_ChIP-Seq_293T-REX_Human1.05368814
71KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04645803
72TDRD3_21172665_ChIP-Seq_MCF-7_Human1.03617096
73SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01825346
74MYC_19079543_ChIP-ChIP_MESCs_Mouse1.01777293
75FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.01591172
76GABP_19822575_ChIP-Seq_HepG2_Human1.00374260
77NANOG_16153702_ChIP-ChIP_HESCs_Human0.97759654
78MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96981915
79UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96670900
80NFE2_27457419_Chip-Seq_LIVER_Mouse0.96427862
81HOXB7_26014856_ChIP-Seq_BT474_Human0.94965546
82MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.94068292
83TCF4_22108803_ChIP-Seq_LS180_Human0.94056145
84CBP_20019798_ChIP-Seq_JUKART_Human0.94020652
85IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.94020652
86ELK1_22589737_ChIP-Seq_MCF10A_Human0.93775098
87GBX2_23144817_ChIP-Seq_PC3_Human0.93545999
88ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92812781
89FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.90854806
90TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.90192280
91CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.90146446
92EZH2_27294783_Chip-Seq_NPCs_Mouse0.89566350
93NCOR_22424771_ChIP-Seq_293T_Human0.89235139
94HOXB4_20404135_ChIP-ChIP_EML_Mouse0.89175173
95CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.89081024
96RNF2_27304074_Chip-Seq_NSC_Mouse0.88589226
97ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.87769301
98TOP2B_26459242_ChIP-Seq_MCF-7_Human0.86933769
99YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.85801323
100IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.85358339

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.28596111
2MP0009379_abnormal_foot_pigmentation2.69833094
3MP0010030_abnormal_orbit_morphology2.43949810
4MP0002938_white_spotting2.40874104
5MP0001529_abnormal_vocalization2.36206208
6MP0002653_abnormal_ependyma_morphology2.34414494
7MP0002102_abnormal_ear_morphology2.33199552
8MP0002837_dystrophic_cardiac_calcinosis2.29191811
9MP0008872_abnormal_physiological_respon2.28282428
10MP0005084_abnormal_gallbladder_morpholo2.14833195
11MP0004142_abnormal_muscle_tone2.10137738
12MP0001293_anophthalmia2.08149558
13MP0008877_abnormal_DNA_methylation1.99852591
14MP0008875_abnormal_xenobiotic_pharmacok1.99410059
15MP0004133_heterotaxia1.97841357
16MP0002234_abnormal_pharynx_morphology1.96646209
17MP0008058_abnormal_DNA_repair1.85931653
18MP0002736_abnormal_nociception_after1.82895177
19MP0002138_abnormal_hepatobiliary_system1.80766825
20MP0001873_stomach_inflammation1.78652572
21MP0005167_abnormal_blood-brain_barrier1.78547415
22MP0006072_abnormal_retinal_apoptosis1.76329309
23MP0008775_abnormal_heart_ventricle1.74697597
24MP0002163_abnormal_gland_morphology1.71259803
25MP0005646_abnormal_pituitary_gland1.66932662
26MP0003787_abnormal_imprinting1.62442281
27MP0000631_abnormal_neuroendocrine_gland1.62200852
28MP0001968_abnormal_touch/_nociception1.59812704
29MP0001485_abnormal_pinna_reflex1.56964419
30MP0002277_abnormal_respiratory_mucosa1.55058011
31MP0009697_abnormal_copulation1.49103758
32MP0003283_abnormal_digestive_organ1.46494460
33MP0003011_delayed_dark_adaptation1.43899082
34MP0003646_muscle_fatigue1.38639609
35MP0001348_abnormal_lacrimal_gland1.38524276
36MP0000372_irregular_coat_pigmentation1.38216219
37MP0006276_abnormal_autonomic_nervous1.34575422
38MP0004885_abnormal_endolymph1.32161381
39MP0003119_abnormal_digestive_system1.31670579
40MP0008789_abnormal_olfactory_epithelium1.30038929
41MP0005253_abnormal_eye_physiology1.28164877
42MP0005645_abnormal_hypothalamus_physiol1.27612467
43MP0005551_abnormal_eye_electrophysiolog1.27443003
44MP0003718_maternal_effect1.25621211
45MP0001984_abnormal_olfaction1.24512784
46MP0003880_abnormal_central_pattern1.24228234
47MP0003123_paternal_imprinting1.21225587
48MP0000049_abnormal_middle_ear1.20443767
49MP0003937_abnormal_limbs/digits/tail_de1.19716915
50MP0001919_abnormal_reproductive_system1.17853978
51MP0003786_premature_aging1.17806829
52MP0003567_abnormal_fetal_cardiomyocyte1.17140864
53MP0000566_synostosis1.14887249
54MP0000778_abnormal_nervous_system1.14769012
55MP0004147_increased_porphyrin_level1.14306170
56MP0003186_abnormal_redox_activity1.11839458
57MP0009053_abnormal_anal_canal1.10916966
58MP0008995_early_reproductive_senescence1.09770218
59MP0003121_genomic_imprinting1.08455080
60MP0000383_abnormal_hair_follicle1.05231999
61MP0003122_maternal_imprinting1.04795447
62MP0004145_abnormal_muscle_electrophysio1.04474639
63MP0005389_reproductive_system_phenotype1.03715460
64MP0005379_endocrine/exocrine_gland_phen1.03381670
65MP0002233_abnormal_nose_morphology1.02301535
66MP0003938_abnormal_ear_development1.02164153
67MP0002272_abnormal_nervous_system1.00608874
68MP0002638_abnormal_pupillary_reflex0.99019422
69MP0005410_abnormal_fertilization0.98433370
70MP0006035_abnormal_mitochondrial_morpho0.98093849
71MP0002210_abnormal_sex_determination0.97564580
72MP0002876_abnormal_thyroid_physiology0.96782272
73MP0002160_abnormal_reproductive_system0.96684459
74MP0004957_abnormal_blastocyst_morpholog0.96533944
75MP0002751_abnormal_autonomic_nervous0.93650644
76MP0001663_abnormal_digestive_system0.90558694
77MP0001835_abnormal_antigen_presentation0.89966451
78MP0004742_abnormal_vestibular_system0.89948813
79MP0005671_abnormal_response_to0.89307678
80MP0003195_calcinosis0.86793518
81MP0000653_abnormal_sex_gland0.86511847
82MP0000427_abnormal_hair_cycle0.86120870
83MP0003878_abnormal_ear_physiology0.85736384
84MP0005377_hearing/vestibular/ear_phenot0.85736384
85MP0003693_abnormal_embryo_hatching0.85678990
86MP0001905_abnormal_dopamine_level0.84985954
87MP0002095_abnormal_skin_pigmentation0.84204377
88MP0000647_abnormal_sebaceous_gland0.83834464
89MP0008932_abnormal_embryonic_tissue0.83075446
90MP0004043_abnormal_pH_regulation0.82984179
91MP0008057_abnormal_DNA_replication0.82188935
92MP0001929_abnormal_gametogenesis0.81686213
93MP0010386_abnormal_urinary_bladder0.81193136
94MP0001286_abnormal_eye_development0.79265053
95MP0005195_abnormal_posterior_eye0.79224771
96MP0001145_abnormal_male_reproductive0.78083656
97MP0010094_abnormal_chromosome_stability0.76676061
98MP0001119_abnormal_female_reproductive0.75669269
99MP0000613_abnormal_salivary_gland0.74672081
100MP0001764_abnormal_homeostasis0.74349995

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)3.75926389
2Increased hepatocellular lipid droplets (HP:0006565)3.59873864
3Mitochondrial inheritance (HP:0001427)3.42696874
4Molar tooth sign on MRI (HP:0002419)3.42127927
5Abnormality of midbrain morphology (HP:0002418)3.42127927
6Acute encephalopathy (HP:0006846)3.39871573
7Colon cancer (HP:0003003)3.37514153
8Lipid accumulation in hepatocytes (HP:0006561)3.30565867
9Abnormal respiratory epithelium morphology (HP:0012253)3.29604353
10Abnormal respiratory motile cilium morphology (HP:0005938)3.29604353
11Nephronophthisis (HP:0000090)3.22387932
12Abnormal mitochondria in muscle tissue (HP:0008316)3.12091672
13Congenital, generalized hypertrichosis (HP:0004540)3.10390867
14Pancreatic fibrosis (HP:0100732)3.09331798
15Increased CSF lactate (HP:0002490)3.04035945
16Pancreatic cysts (HP:0001737)3.01259424
17Progressive macrocephaly (HP:0004481)2.96703026
18Pendular nystagmus (HP:0012043)2.90444686
19Abnormal ciliary motility (HP:0012262)2.83243943
20Reticulocytopenia (HP:0001896)2.82882814
21Abnormality of the renal cortex (HP:0011035)2.82847622
22Renal Fanconi syndrome (HP:0001994)2.76050805
23Abnormality of cells of the erythroid lineage (HP:0012130)2.75450414
24Abnormality of the renal medulla (HP:0100957)2.74101280
25Abnormality of the labia minora (HP:0012880)2.62401626
26Supernumerary spleens (HP:0009799)2.59140356
27Hypoplasia of the ulna (HP:0003022)2.58589894
28True hermaphroditism (HP:0010459)2.57995775
29Dynein arm defect of respiratory motile cilia (HP:0012255)2.56754269
30Absent/shortened dynein arms (HP:0200106)2.56754269
31Hepatocellular necrosis (HP:0001404)2.52248438
32Stenosis of the external auditory canal (HP:0000402)2.47687742
33Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.47682468
34Absent thumb (HP:0009777)2.46792527
35Abnormality of the phalanges of the 2nd finger (HP:0009541)2.44322778
36Cerebral edema (HP:0002181)2.42389121
37Aplasia/Hypoplasia of the ulna (HP:0006495)2.38928373
38Abnormal respiratory motile cilium physiology (HP:0012261)2.38411236
39Hepatic necrosis (HP:0002605)2.36575653
40Renal cortical cysts (HP:0000803)2.34656261
41Medial flaring of the eyebrow (HP:0010747)2.31165179
423-Methylglutaconic aciduria (HP:0003535)2.31064799
43Large for gestational age (HP:0001520)2.26780010
44Oligodactyly (HP:0012165)2.26360190
45Exertional dyspnea (HP:0002875)2.25667336
46IgG deficiency (HP:0004315)2.23085455
47Forearm undergrowth (HP:0009821)2.21852584
48Abnormal number of erythroid precursors (HP:0012131)2.21204373
49Chronic hepatic failure (HP:0100626)2.19319959
50Hyperglycinemia (HP:0002154)2.17193375
51Septo-optic dysplasia (HP:0100842)2.16887424
52Abnormality of alanine metabolism (HP:0010916)2.13144726
53Hyperalaninemia (HP:0003348)2.13144726
54Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.13144726
55Respiratory difficulties (HP:0002880)2.12873237
56Optic nerve hypoplasia (HP:0000609)2.12753301
57Thyroid-stimulating hormone excess (HP:0002925)2.12247922
58Macrocytic anemia (HP:0001972)2.09817268
59Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.09307647
60Abnormality of DNA repair (HP:0003254)2.07936394
61Increased intramyocellular lipid droplets (HP:0012240)2.07913895
62Postaxial foot polydactyly (HP:0001830)2.06629201
63Methylmalonic acidemia (HP:0002912)2.06585082
64Increased serum lactate (HP:0002151)2.06154388
65Abnormality of the phalanges of the 5th finger (HP:0004213)2.05718837
66Fibular aplasia (HP:0002990)2.04240759
67Oligodactyly (hands) (HP:0001180)2.04210292
68Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.02498223
69Abnormality of the proximal phalanges of the hand (HP:0009834)2.02433329
70Tubular atrophy (HP:0000092)2.02264807
71Humeroradial synostosis (HP:0003041)2.01640745
72Synostosis involving the elbow (HP:0003938)2.01640745
73Horseshoe kidney (HP:0000085)2.01479011
74Stomatitis (HP:0010280)1.95690967
75Abnormality of the middle phalanges of the toes (HP:0010183)1.94801075
76Lactic acidosis (HP:0003128)1.94489906
77Type II lissencephaly (HP:0007260)1.93049217
78Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.91940142
79Rectovaginal fistula (HP:0000143)1.91512483
80Rectal fistula (HP:0100590)1.91512483
81Sclerocornea (HP:0000647)1.90336124
82Aplasia/Hypoplasia of the spleen (HP:0010451)1.89543014
83Anophthalmia (HP:0000528)1.87596514
84Congenital stationary night blindness (HP:0007642)1.83188908
85Asplenia (HP:0001746)1.82521158
86Fibular hypoplasia (HP:0003038)1.81201738
87Postaxial hand polydactyly (HP:0001162)1.80175638
88Congenital hepatic fibrosis (HP:0002612)1.80068921
89Adrenal hypoplasia (HP:0000835)1.76333960
90Abnormality of the renal collecting system (HP:0004742)1.75693368
91Optic disc pallor (HP:0000543)1.75412450
92Metabolic alkalosis (HP:0200114)1.75264505
93Abnormality of renal resorption (HP:0011038)1.74207548
94Meckel diverticulum (HP:0002245)1.74189181
95Recurrent cutaneous fungal infections (HP:0011370)1.73113020
96Chronic mucocutaneous candidiasis (HP:0002728)1.73113020
97Aplasia/Hypoplasia of the tongue (HP:0010295)1.72329769
98Ectopic kidney (HP:0000086)1.72198155
99Hypoplasia of the radius (HP:0002984)1.71283900
100Rib fusion (HP:0000902)1.71031526

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.11889222
2PDK23.02718537
3ZAK2.96590194
4EIF2AK12.90653016
5TLK12.84944390
6MAP4K22.64480403
7TNIK2.62093515
8EIF2AK32.57487942
9TIE12.35189777
10MST42.30904953
11NUAK12.29181976
12TAF12.28999196
13SRPK12.20259655
14WNK42.18587804
15CDC71.94561222
16VRK11.92971948
17MKNK11.84030442
18MKNK21.82809217
19TSSK61.73016194
20BUB11.71687221
21STK161.68947531
22EIF2AK21.59564180
23ADRBK21.55050078
24PNCK1.50696065
25WNK31.50390796
26TXK1.49166058
27BMPR1B1.45888782
28INSRR1.44815765
29PINK11.42198540
30PLK31.37074878
31TAOK31.30640988
32DYRK21.30397245
33GRK11.29848167
34STK391.29498489
35CDK191.28479256
36EPHA41.23864570
37WEE11.16688918
38FRK1.15252838
39BCR1.11500965
40TRIM281.01635290
41CAMKK20.99442010
42PIK3CA0.97828878
43PBK0.90883396
44CSNK1G20.87718819
45MAPK130.84216290
46TEC0.83428684
47PAK30.81893653
48CDK80.81199738
49NEK10.79580215
50STK40.79325060
51PTK2B0.78364452
52STK30.78345048
53OXSR10.76310128
54CCNB10.74766413
55PRKCQ0.73832739
56CSNK1G30.73167129
57PLK40.73078702
58MAP3K120.71843448
59CSNK1G10.69359065
60CSF1R0.68218324
61CASK0.67217117
62RPS6KA50.65962072
63NLK0.65412162
64PLK10.60704523
65TGFBR10.60429428
66STK38L0.57765851
67PRKCG0.55690028
68PASK0.54588300
69BCKDK0.52750970
70NME10.52097986
71CSNK2A20.51955226
72AURKB0.49908707
73CSNK1E0.48817558
74STK240.48790393
75CSNK1A1L0.48266366
76CAMK1G0.44479999
77BRSK20.44348922
78CSNK2A10.43241161
79ATR0.42097913
80CHEK20.41507043
81PLK20.41446920
82CAMK10.39613330
83PHKG10.39100058
84PHKG20.39100058
85MUSK0.38678355
86FGFR20.36718619
87MATK0.36525717
88DAPK10.35407494
89DAPK30.34521894
90IKBKB0.34133439
91BRD40.33369776
92NEK20.33366150
93EPHB20.30824085
94IGF1R0.30650145
95IKBKE0.28401570
96PKN10.27998594
97MYLK0.27969475
98ATM0.27915859
99CSNK1A10.27798308
100LMTK20.27250969

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.78886331
2Proteasome_Homo sapiens_hsa030503.51176004
3Oxidative phosphorylation_Homo sapiens_hsa001903.43184034
4Protein export_Homo sapiens_hsa030603.09537385
5RNA polymerase_Homo sapiens_hsa030202.91375747
6Parkinsons disease_Homo sapiens_hsa050122.72056286
7Homologous recombination_Homo sapiens_hsa034402.37154848
8Basal transcription factors_Homo sapiens_hsa030222.32927569
9RNA degradation_Homo sapiens_hsa030182.11916199
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.09998905
11Spliceosome_Homo sapiens_hsa030402.01875930
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.92451108
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.90700624
14Linoleic acid metabolism_Homo sapiens_hsa005911.88625120
15Huntingtons disease_Homo sapiens_hsa050161.87532531
16Nitrogen metabolism_Homo sapiens_hsa009101.69634097
17Mismatch repair_Homo sapiens_hsa034301.66677156
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.66647697
19Alzheimers disease_Homo sapiens_hsa050101.61470938
20Fanconi anemia pathway_Homo sapiens_hsa034601.61115670
21Propanoate metabolism_Homo sapiens_hsa006401.58643765
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.58373332
23Nucleotide excision repair_Homo sapiens_hsa034201.56227404
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.51067674
25Asthma_Homo sapiens_hsa053101.50420223
26RNA transport_Homo sapiens_hsa030131.45082377
27Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.42367264
28Pyrimidine metabolism_Homo sapiens_hsa002401.40649183
29Systemic lupus erythematosus_Homo sapiens_hsa053221.32753755
30Cardiac muscle contraction_Homo sapiens_hsa042601.31883613
31Caffeine metabolism_Homo sapiens_hsa002321.27285822
32Phototransduction_Homo sapiens_hsa047441.22349060
33Sulfur relay system_Homo sapiens_hsa041221.22080292
34Tryptophan metabolism_Homo sapiens_hsa003801.21327098
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.17160789
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.14644785
37Allograft rejection_Homo sapiens_hsa053301.13386416
38Autoimmune thyroid disease_Homo sapiens_hsa053201.12987271
39Purine metabolism_Homo sapiens_hsa002301.10575789
40Arachidonic acid metabolism_Homo sapiens_hsa005901.10313762
41One carbon pool by folate_Homo sapiens_hsa006701.08722821
42Collecting duct acid secretion_Homo sapiens_hsa049661.06243527
43Butanoate metabolism_Homo sapiens_hsa006501.05610274
44Fat digestion and absorption_Homo sapiens_hsa049751.05483302
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.02969871
46DNA replication_Homo sapiens_hsa030301.02714013
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.00954956
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.98202778
49Base excision repair_Homo sapiens_hsa034100.94101380
50Basal cell carcinoma_Homo sapiens_hsa052170.92027987
51Retinol metabolism_Homo sapiens_hsa008300.91814673
52Fatty acid elongation_Homo sapiens_hsa000620.91542008
53Chemical carcinogenesis_Homo sapiens_hsa052040.91257414
54Peroxisome_Homo sapiens_hsa041460.90775089
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.87366345
56Primary immunodeficiency_Homo sapiens_hsa053400.86727101
57Hedgehog signaling pathway_Homo sapiens_hsa043400.84899877
58Glutathione metabolism_Homo sapiens_hsa004800.84518696
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.84423339
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.83591349
61Ether lipid metabolism_Homo sapiens_hsa005650.82853677
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81333313
63Maturity onset diabetes of the young_Homo sapiens_hsa049500.80715875
64Pyruvate metabolism_Homo sapiens_hsa006200.76473007
65Alcoholism_Homo sapiens_hsa050340.74415545
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74149640
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.72032353
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.71640374
69Metabolic pathways_Homo sapiens_hsa011000.71208628
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68815775
71Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.67398524
72Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64357474
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.62763763
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.61507977
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61227512
76Non-homologous end-joining_Homo sapiens_hsa034500.60977443
77beta-Alanine metabolism_Homo sapiens_hsa004100.59925417
78Sulfur metabolism_Homo sapiens_hsa009200.58089274
79Steroid biosynthesis_Homo sapiens_hsa001000.57919107
80Fatty acid degradation_Homo sapiens_hsa000710.56027372
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.51781466
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48757762
83ABC transporters_Homo sapiens_hsa020100.47791454
84Nicotine addiction_Homo sapiens_hsa050330.47509727
85Fatty acid metabolism_Homo sapiens_hsa012120.44220398
86Olfactory transduction_Homo sapiens_hsa047400.42329422
87Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.38967800
88Folate biosynthesis_Homo sapiens_hsa007900.38667520
89Vitamin digestion and absorption_Homo sapiens_hsa049770.36716168
90Epstein-Barr virus infection_Homo sapiens_hsa051690.35372272
91Cell cycle_Homo sapiens_hsa041100.35294231
92Arginine and proline metabolism_Homo sapiens_hsa003300.32962022
93Rheumatoid arthritis_Homo sapiens_hsa053230.31106568
94N-Glycan biosynthesis_Homo sapiens_hsa005100.30661856
95Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.30155949
96Glycerolipid metabolism_Homo sapiens_hsa005610.30017417
97Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.28903466
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28006128
99Antigen processing and presentation_Homo sapiens_hsa046120.24747988
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.22290840

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »