NAP1L5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that shares sequence similarity to nucleosome assembly factors, but may be localized to the cytoplasm rather than the nucleus. Expression of this gene is downregulated in hepatocellular carcinomas. This gene is located within a differentially methylated region (DMR) and is imprinted and paternally expressed. There is a related pseudogene on chromosome 4. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.89983771
2synaptic vesicle maturation (GO:0016188)5.27627669
3synaptic vesicle exocytosis (GO:0016079)5.26834762
4locomotory exploration behavior (GO:0035641)5.17322110
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.15531036
6vocalization behavior (GO:0071625)5.15125714
7neuron cell-cell adhesion (GO:0007158)5.00203757
8regulation of synaptic vesicle exocytosis (GO:2000300)4.98254936
9neurotransmitter secretion (GO:0007269)4.82197406
10glutamate secretion (GO:0014047)4.75446006
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.58327865
12neuronal action potential propagation (GO:0019227)4.56788984
13positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.52630149
14regulation of glutamate receptor signaling pathway (GO:1900449)4.51731870
15regulation of synaptic vesicle transport (GO:1902803)4.40578838
16gamma-aminobutyric acid transport (GO:0015812)4.38308723
17protein localization to synapse (GO:0035418)4.33620722
18regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.32401502
19neuromuscular process controlling posture (GO:0050884)4.29077100
20ionotropic glutamate receptor signaling pathway (GO:0035235)4.27668958
21neurotransmitter transport (GO:0006836)4.18342317
22exploration behavior (GO:0035640)4.14997086
23gamma-aminobutyric acid signaling pathway (GO:0007214)4.03459352
24positive regulation of synapse maturation (GO:0090129)3.91312146
25positive regulation of synaptic transmission, GABAergic (GO:0032230)3.88741953
26proline transport (GO:0015824)3.85934305
27glutamate receptor signaling pathway (GO:0007215)3.84952715
28regulation of neurotransmitter levels (GO:0001505)3.81765338
29cellular potassium ion homeostasis (GO:0030007)3.78273407
30transmission of nerve impulse (GO:0019226)3.77589745
31positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.76559967
32regulation of neuronal synaptic plasticity (GO:0048168)3.76113048
33neuron-neuron synaptic transmission (GO:0007270)3.75384631
34neuron recognition (GO:0008038)3.73584812
35layer formation in cerebral cortex (GO:0021819)3.71935036
36negative regulation of synaptic transmission, GABAergic (GO:0032229)3.71805848
37synaptic transmission, glutamatergic (GO:0035249)3.69177651
38activation of protein kinase A activity (GO:0034199)3.67202561
39regulation of voltage-gated calcium channel activity (GO:1901385)3.66356491
40establishment of mitochondrion localization (GO:0051654)3.64525646
41positive regulation of neurotransmitter transport (GO:0051590)3.63988536
42regulation of long-term neuronal synaptic plasticity (GO:0048169)3.61964127
43positive regulation of dendritic spine development (GO:0060999)3.60223919
44long-term memory (GO:0007616)3.56343409
45mating behavior (GO:0007617)3.50254924
46L-amino acid import (GO:0043092)3.50135926
47positive regulation of dendritic spine morphogenesis (GO:0061003)3.49632921
48pyrimidine nucleobase catabolic process (GO:0006208)3.46036638
49synaptic vesicle docking involved in exocytosis (GO:0016081)3.43720582
50auditory behavior (GO:0031223)3.43243685
51cerebellar Purkinje cell differentiation (GO:0021702)3.38267415
52regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.36372832
53amino acid import (GO:0043090)3.34992808
54neurotransmitter-gated ion channel clustering (GO:0072578)3.34181356
55positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.33638917
56sodium ion export (GO:0071436)3.32100016
57membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.30329716
58synaptic vesicle endocytosis (GO:0048488)3.29546307
59dendritic spine morphogenesis (GO:0060997)3.28610301
60regulation of vesicle fusion (GO:0031338)3.28461181
61axonal fasciculation (GO:0007413)3.27853913
62response to histamine (GO:0034776)3.26978744
63regulation of dendritic spine morphogenesis (GO:0061001)3.26140609
64positive regulation of synapse assembly (GO:0051965)3.23778259
65regulation of glutamate secretion (GO:0014048)3.23605272
66regulation of synapse structural plasticity (GO:0051823)3.22950271
67potassium ion import (GO:0010107)3.22659751
68positive regulation of neurotransmitter secretion (GO:0001956)3.21032962
69regulation of excitatory postsynaptic membrane potential (GO:0060079)3.20062396
70regulation of neurotransmitter secretion (GO:0046928)3.19387799
71detection of calcium ion (GO:0005513)3.19187150
72neuromuscular synaptic transmission (GO:0007274)3.18702956
73regulation of protein kinase A signaling (GO:0010738)3.18652400
74postsynaptic membrane organization (GO:0001941)3.18282384
75presynaptic membrane assembly (GO:0097105)3.16416495
76positive regulation of potassium ion transmembrane transport (GO:1901381)3.16047668
77establishment of synaptic vesicle localization (GO:0097480)3.15777417
78synaptic vesicle transport (GO:0048489)3.15777417
79positive regulation of membrane potential (GO:0045838)3.15030438
80regulation of postsynaptic membrane potential (GO:0060078)3.14780152
81regulation of dendritic spine development (GO:0060998)3.14674289
82cell migration in hindbrain (GO:0021535)3.14573883
83regulation of synaptic transmission, glutamatergic (GO:0051966)3.14214711
84long-term synaptic potentiation (GO:0060291)3.12888467
85regulation of synaptic transmission, GABAergic (GO:0032228)3.12198118
86membrane hyperpolarization (GO:0060081)3.12169704
87regulation of synapse maturation (GO:0090128)3.11990153
88vesicle transport along microtubule (GO:0047496)3.10710204
89startle response (GO:0001964)3.10614764
90nucleobase catabolic process (GO:0046113)3.09701101
91glycine transport (GO:0015816)3.08741146
92synapse assembly (GO:0007416)3.06198591
93presynaptic membrane organization (GO:0097090)3.06123273
94adult walking behavior (GO:0007628)3.05510346
95membrane depolarization during action potential (GO:0086010)3.05225102
96neurotransmitter catabolic process (GO:0042135)3.03830829
97regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.03726723
98social behavior (GO:0035176)3.03364661
99intraspecies interaction between organisms (GO:0051703)3.03364661
100negative regulation of dendrite morphogenesis (GO:0050774)3.02972892
101regulation of neurotransmitter transport (GO:0051588)3.02004484
102cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.01954889
103negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.01798416
104cellular sodium ion homeostasis (GO:0006883)3.01525905
105synaptic transmission (GO:0007268)2.99322564
106behavioral response to cocaine (GO:0048148)2.99210070
107neuronal ion channel clustering (GO:0045161)2.99088158
108establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.98896855
109mitochondrion transport along microtubule (GO:0047497)2.98896855
110behavioral defense response (GO:0002209)2.98892949
111negative regulation of amino acid transport (GO:0051956)2.97421671
112G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.96902151
113positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.96338190
114response to auditory stimulus (GO:0010996)2.95211357
115neurotransmitter uptake (GO:0001504)2.94522263
116regulation of synaptic plasticity (GO:0048167)2.94060742
117potassium ion homeostasis (GO:0055075)2.93559499
118membrane depolarization (GO:0051899)2.92111242
119response to pheromone (GO:0019236)2.90678184
120negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.90187704
121prepulse inhibition (GO:0060134)2.89845436
122regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.89284876
123neuromuscular process controlling balance (GO:0050885)2.86434892
124cerebellar granule cell differentiation (GO:0021707)2.86005513
125regulation of synaptic transmission (GO:0050804)2.85310339
126positive regulation of synaptic transmission (GO:0050806)2.84464546
127calcium ion-dependent exocytosis (GO:0017156)2.83088285

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.17048883
2GBX2_23144817_ChIP-Seq_PC3_Human3.45739154
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.14151099
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.08583841
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.02088122
6REST_21632747_ChIP-Seq_MESCs_Mouse2.80619359
7JARID2_20075857_ChIP-Seq_MESCs_Mouse2.60898846
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.59786439
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.59786439
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.59201520
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.54278744
12* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.54090720
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.53736004
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.51479862
15CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.51185687
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.47881978
17TAF15_26573619_Chip-Seq_HEK293_Human2.40601770
18NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.34629105
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.32227621
20REST_18959480_ChIP-ChIP_MESCs_Mouse2.29478066
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.22767469
22RARB_27405468_Chip-Seq_BRAIN_Mouse2.21414975
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.19330331
24IKZF1_21737484_ChIP-ChIP_HCT116_Human2.18609583
25DROSHA_22980978_ChIP-Seq_HELA_Human2.16977868
26CTBP2_25329375_ChIP-Seq_LNCAP_Human2.06122251
27RNF2_27304074_Chip-Seq_ESCs_Mouse2.03847038
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.03249154
29AR_21572438_ChIP-Seq_LNCaP_Human2.01226941
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.85707124
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.84688159
32* SMAD4_21799915_ChIP-Seq_A2780_Human1.73602650
33RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.68850731
34BMI1_23680149_ChIP-Seq_NPCS_Mouse1.67034191
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.65284740
36ZNF274_21170338_ChIP-Seq_K562_Hela1.62993899
37MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.57286399
38ERG_21242973_ChIP-ChIP_JURKAT_Human1.54127276
39IGF1R_20145208_ChIP-Seq_DFB_Human1.53798600
40P300_19829295_ChIP-Seq_ESCs_Human1.51381176
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43089945
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.42650060
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.42270498
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41517102
45EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35895464
46PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.35731983
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35237324
48NR3C1_23031785_ChIP-Seq_PC12_Mouse1.34445551
49RNF2_27304074_Chip-Seq_NSC_Mouse1.34354669
50ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.34021360
51* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33188029
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.32470145
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31237627
54SOX2_21211035_ChIP-Seq_LN229_Gbm1.31035643
55TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30558029
56AR_25329375_ChIP-Seq_VCAP_Human1.30275871
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.26768530
58OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26150714
59CDX2_19796622_ChIP-Seq_MESCs_Mouse1.24394744
60RING1B_27294783_Chip-Seq_ESCs_Mouse1.23958816
61RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.23514624
62STAT3_23295773_ChIP-Seq_U87_Human1.19682581
63SMAD_19615063_ChIP-ChIP_OVARY_Human1.18530048
64* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.17905877
65POU3F2_20337985_ChIP-ChIP_501MEL_Human1.17078458
66TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13311339
67ER_23166858_ChIP-Seq_MCF-7_Human1.11768336
68DNAJC2_21179169_ChIP-ChIP_NT2_Human1.11363449
69THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.11122432
70VDR_22108803_ChIP-Seq_LS180_Human1.11027735
71AR_19668381_ChIP-Seq_PC3_Human1.10235703
72CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10061133
73CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.09539156
74FUS_26573619_Chip-Seq_HEK293_Human1.09248266
75MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07303793
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06739122
77RUNX2_22187159_ChIP-Seq_PCA_Human1.05853649
78TCF4_23295773_ChIP-Seq_U87_Human1.05060353
79P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03844366
80* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03364429
81* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.01652185
82OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.99560039
83JUN_21703547_ChIP-Seq_K562_Human0.97604693
84TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97321449
85POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97321449
86LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96850697
87AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96516249
88ZFP281_18757296_ChIP-ChIP_E14_Mouse0.96360176
89TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95870619
90SMAD3_21741376_ChIP-Seq_ESCs_Human0.95476770
91TET1_21490601_ChIP-Seq_MESCs_Mouse0.95439935
92PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95326093
93NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94996507
94GATA1_26923725_Chip-Seq_HPCs_Mouse0.92757768
95WT1_25993318_ChIP-Seq_PODOCYTE_Human0.92387272
96ARNT_22903824_ChIP-Seq_MCF-7_Human0.91631724
97YAP1_20516196_ChIP-Seq_MESCs_Mouse0.90248445
98PRDM14_20953172_ChIP-Seq_ESCs_Human0.90166048
99RING1B_27294783_Chip-Seq_NPCs_Mouse0.89712245
100SOX9_26525672_Chip-Seq_HEART_Mouse0.87114879
101KDM2B_26808549_Chip-Seq_REH_Human0.86660937
102KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.86172338
103CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.85969356
104GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.85340212
105AHR_22903824_ChIP-Seq_MCF-7_Human0.85257970
106SMAD4_21741376_ChIP-Seq_HESCs_Human0.83281710
107CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.83172567
108CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.82843675
109TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.82625011
110NANOG_18555785_Chip-Seq_ESCs_Mouse0.82471131
111TP53_20018659_ChIP-ChIP_R1E_Mouse0.81544770
112ZNF217_24962896_ChIP-Seq_MCF-7_Human0.80509461
113BCAT_22108803_ChIP-Seq_LS180_Human0.80050824
114FLI1_21867929_ChIP-Seq_TH2_Mouse0.79407719
115SMAD4_21741376_ChIP-Seq_EPCs_Human0.79274142
116CBP_20019798_ChIP-Seq_JUKART_Human0.78971969

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.97024913
2MP0004859_abnormal_synaptic_plasticity4.93253711
3MP0003635_abnormal_synaptic_transmissio3.80791802
4MP0009046_muscle_twitch3.50125627
5MP0009745_abnormal_behavioral_response3.32949417
6MP0001968_abnormal_touch/_nociception3.31405483
7MP0002064_seizures3.26114243
8MP0005423_abnormal_somatic_nervous2.98899007
9MP0004270_analgesia2.91155766
10MP0002063_abnormal_learning/memory/cond2.89217850
11MP0003122_maternal_imprinting2.88755367
12MP0006276_abnormal_autonomic_nervous2.85781888
13MP0002572_abnormal_emotion/affect_behav2.72698546
14MP0002272_abnormal_nervous_system2.72482707
15MP0001501_abnormal_sleep_pattern2.64354454
16MP0002734_abnormal_mechanical_nocicepti2.54465176
17MP0002736_abnormal_nociception_after2.47119655
18MP0001486_abnormal_startle_reflex2.43959472
19MP0001440_abnormal_grooming_behavior2.38650419
20MP0005645_abnormal_hypothalamus_physiol2.28521109
21MP0002735_abnormal_chemical_nociception2.20393155
22MP0002733_abnormal_thermal_nociception2.18812259
23MP0002067_abnormal_sensory_capabilities2.14434039
24MP0001970_abnormal_pain_threshold2.04892747
25MP0004142_abnormal_muscle_tone2.01583021
26MP0002822_catalepsy1.98489154
27MP0005386_behavior/neurological_phenoty1.83994437
28MP0004924_abnormal_behavior1.83994437
29MP0002557_abnormal_social/conspecific_i1.83014732
30MP0003329_amyloid_beta_deposits1.83009096
31MP0002184_abnormal_innervation1.80098041
32MP0005646_abnormal_pituitary_gland1.78301169
33MP0001529_abnormal_vocalization1.77549399
34MP0008569_lethality_at_weaning1.71464648
35MP0001984_abnormal_olfaction1.67211868
36MP0001905_abnormal_dopamine_level1.65346192
37MP0002909_abnormal_adrenal_gland1.65046804
38MP0003787_abnormal_imprinting1.56722873
39MP0000778_abnormal_nervous_system1.50266576
40MP0001502_abnormal_circadian_rhythm1.47238019
41MP0004858_abnormal_nervous_system1.44026620
42MP0000955_abnormal_spinal_cord1.43830145
43MP0004811_abnormal_neuron_physiology1.43320168
44MP0002066_abnormal_motor_capabilities/c1.42019484
45MP0009780_abnormal_chondrocyte_physiolo1.37139255
46MP0002882_abnormal_neuron_morphology1.35709438
47MP0004885_abnormal_endolymph1.33002403
48MP0000013_abnormal_adipose_tissue1.27124062
49MP0000751_myopathy1.23786801
50MP0003121_genomic_imprinting1.23051550
51MP0003633_abnormal_nervous_system1.20954920
52MP0003123_paternal_imprinting1.20399139
53MP0001188_hyperpigmentation1.17790914
54MP0004145_abnormal_muscle_electrophysio1.17689659
55MP0008877_abnormal_DNA_methylation1.16389642
56MP0005551_abnormal_eye_electrophysiolog1.15822293
57MP0002229_neurodegeneration1.13345232
58MP0003879_abnormal_hair_cell1.11536877
59MP0002837_dystrophic_cardiac_calcinosis1.09428525
60MP0003690_abnormal_glial_cell1.08445853
61MP0004742_abnormal_vestibular_system1.07823700
62MP0008872_abnormal_physiological_respon1.07239555
63MP0010386_abnormal_urinary_bladder1.06016242
64MP0006072_abnormal_retinal_apoptosis1.04150713
65MP0003631_nervous_system_phenotype1.03365388
66MP0004147_increased_porphyrin_level1.00217960
67MP0002638_abnormal_pupillary_reflex0.98859786
68MP0002152_abnormal_brain_morphology0.97239531
69MP0003634_abnormal_glial_cell0.96874250
70MP0000920_abnormal_myelination0.94684581
71MP0005535_abnormal_body_temperature0.94317170
72MP0002069_abnormal_eating/drinking_beha0.93542661
73MP0001986_abnormal_taste_sensitivity0.92488656
74MP0003283_abnormal_digestive_organ0.86763717
75MP0000631_abnormal_neuroendocrine_gland0.84478352
76MP0001963_abnormal_hearing_physiology0.83628893
77MP0002752_abnormal_somatic_nervous0.82013302
78MP0000604_amyloidosis0.80463983
79MP0002876_abnormal_thyroid_physiology0.79744613
80MP0003632_abnormal_nervous_system0.78993271
81MP0008874_decreased_physiological_sensi0.78088611
82MP0001177_atelectasis0.76833982
83MP0004085_abnormal_heartbeat0.75601689
84MP0008961_abnormal_basal_metabolism0.73126281
85MP0005499_abnormal_olfactory_system0.71218058
86MP0005394_taste/olfaction_phenotype0.71218058
87MP0002090_abnormal_vision0.71018052
88MP0004215_abnormal_myocardial_fiber0.70183333
89MP0005379_endocrine/exocrine_gland_phen0.69815370
90MP0005623_abnormal_meninges_morphology0.67631806
91MP0000747_muscle_weakness0.65009922
92MP0004043_abnormal_pH_regulation0.64399574
93MP0003137_abnormal_impulse_conducting0.63725162
94MP0005253_abnormal_eye_physiology0.63276225
95MP0000569_abnormal_digit_pigmentation0.63228147
96MP0000026_abnormal_inner_ear0.62350422
97MP0001943_abnormal_respiration0.62242503
98MP0001664_abnormal_digestion0.62085773
99MP0000639_abnormal_adrenal_gland0.61554126
100MP0003861_abnormal_nervous_system0.60274850
101MP0001299_abnormal_eye_distance/0.59504450
102MP0004233_abnormal_muscle_weight0.58639797
103MP0010769_abnormal_survival0.58152653
104MP0005187_abnormal_penis_morphology0.58146892
105MP0010770_preweaning_lethality0.57975734
106MP0002082_postnatal_lethality0.57975734
107MP0010768_mortality/aging0.55713390
108MP0002102_abnormal_ear_morphology0.53635698
109MP0001485_abnormal_pinna_reflex0.52776686
110MP0003956_abnormal_body_size0.51060932
111MP0003183_abnormal_peptide_metabolism0.50009255
112MP0004484_altered_response_of0.49579543
113MP0004130_abnormal_muscle_cell0.47660883
114MP0005167_abnormal_blood-brain_barrier0.45815045

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.39543057
2Myokymia (HP:0002411)5.81899006
3Focal seizures (HP:0007359)5.42741063
4Visual hallucinations (HP:0002367)5.30352177
5Atonic seizures (HP:0010819)5.24971843
6Absence seizures (HP:0002121)4.59757544
7Febrile seizures (HP:0002373)4.54215222
8Epileptic encephalopathy (HP:0200134)4.38767832
9Progressive cerebellar ataxia (HP:0002073)4.34638491
10Dialeptic seizures (HP:0011146)4.12685717
11Generalized tonic-clonic seizures (HP:0002069)4.01471974
12Supranuclear gaze palsy (HP:0000605)3.74483381
13Abnormal eating behavior (HP:0100738)3.66017907
14Polyphagia (HP:0002591)3.58685546
15Action tremor (HP:0002345)3.38255334
16Progressive inability to walk (HP:0002505)3.33353037
17Failure to thrive in infancy (HP:0001531)3.32415655
18Ankle clonus (HP:0011448)3.15838527
19Anxiety (HP:0000739)3.11040985
20Pheochromocytoma (HP:0002666)3.10109595
21Depression (HP:0000716)3.04538290
22Truncal ataxia (HP:0002078)3.03476264
23Dysdiadochokinesis (HP:0002075)3.01714052
24Limb dystonia (HP:0002451)2.96470538
25Dysmetria (HP:0001310)2.94562781
26Mutism (HP:0002300)2.92890540
27Broad-based gait (HP:0002136)2.89521561
28Akinesia (HP:0002304)2.86719766
29Postural instability (HP:0002172)2.77901047
30Neuroendocrine neoplasm (HP:0100634)2.75464491
31Amyotrophic lateral sclerosis (HP:0007354)2.74831240
32Gaze-evoked nystagmus (HP:0000640)2.74650406
33Neurofibrillary tangles (HP:0002185)2.72536098
34Impaired vibration sensation in the lower limbs (HP:0002166)2.71752860
35Agitation (HP:0000713)2.66254270
36Scanning speech (HP:0002168)2.64775681
37Hyperventilation (HP:0002883)2.64733829
38Cerebral hypomyelination (HP:0006808)2.62101357
39Papilledema (HP:0001085)2.61334264
40Abnormal hair whorl (HP:0010721)2.61080054
41Urinary bladder sphincter dysfunction (HP:0002839)2.57428821
42Poor eye contact (HP:0000817)2.56239946
43Hemiparesis (HP:0001269)2.53546148
44Spastic gait (HP:0002064)2.47380480
45Impaired social interactions (HP:0000735)2.45695473
46Abnormal social behavior (HP:0012433)2.45695473
47Psychosis (HP:0000709)2.44471793
48Morphological abnormality of the pyramidal tract (HP:0002062)2.42686923
49Delusions (HP:0000746)2.40658264
50Diplopia (HP:0000651)2.40312399
51Abnormality of binocular vision (HP:0011514)2.40312399
52Excessive salivation (HP:0003781)2.38819092
53Drooling (HP:0002307)2.38819092
54Poor suck (HP:0002033)2.37712563
55Craniofacial dystonia (HP:0012179)2.37589228
56Cerebral inclusion bodies (HP:0100314)2.37148466
57Urinary urgency (HP:0000012)2.36673785
58Hemiplegia (HP:0002301)2.36461948
59Status epilepticus (HP:0002133)2.35942811
60Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.35139172
61Bradykinesia (HP:0002067)2.34378306
62Abnormality of the corticospinal tract (HP:0002492)2.34180889
63Genetic anticipation (HP:0003743)2.32651170
64Amblyopia (HP:0000646)2.30915181
65Hypoventilation (HP:0002791)2.29545861
66Clonus (HP:0002169)2.29478115
67Gait imbalance (HP:0002141)2.28783712
68Esotropia (HP:0000565)2.28732737
69Intention tremor (HP:0002080)2.28564044
70Impaired vibratory sensation (HP:0002495)2.28016632
71Ventricular fibrillation (HP:0001663)2.27112085
72Generalized myoclonic seizures (HP:0002123)2.25974559
73Spastic tetraplegia (HP:0002510)2.21196167
74Oligomenorrhea (HP:0000876)2.20540359
75Retinal dysplasia (HP:0007973)2.18257143
76Narrow nasal bridge (HP:0000446)2.18120557
77Menstrual irregularities (HP:0000858)2.17943275
78Specific learning disability (HP:0001328)2.17940688
79Epileptiform EEG discharges (HP:0011182)2.17896234
80EEG with generalized epileptiform discharges (HP:0011198)2.17488559
81Termporal pattern (HP:0011008)2.17432536
82Insidious onset (HP:0003587)2.17432536
83Abnormality of the lower motor neuron (HP:0002366)2.16892064
84Obstructive sleep apnea (HP:0002870)2.16169471
85Tetraplegia (HP:0002445)2.15639535
86Inability to walk (HP:0002540)2.11836656
87Impaired smooth pursuit (HP:0007772)2.10688805
88Peripheral hypomyelination (HP:0007182)2.10669444
89Apathy (HP:0000741)2.10613315
90Lower limb muscle weakness (HP:0007340)2.05675919
91Hypsarrhythmia (HP:0002521)2.04605785
92CNS hypomyelination (HP:0003429)2.03805227
93Absent speech (HP:0001344)2.02978474
94Fetal akinesia sequence (HP:0001989)2.01254986
95Annular pancreas (HP:0001734)2.00133047
96Sleep apnea (HP:0010535)1.98176202
97Neuronal loss in central nervous system (HP:0002529)1.97653140
98Congenital primary aphakia (HP:0007707)1.97060198
99Muscular hypotonia of the trunk (HP:0008936)1.95743917
100Abnormality of the labia minora (HP:0012880)1.95569193
101Blue irides (HP:0000635)1.95382706
102Torticollis (HP:0000473)1.94186747
103Abnormal ciliary motility (HP:0012262)1.93754434
104Incomplete penetrance (HP:0003829)1.92887508
105Hypoplasia of the corpus callosum (HP:0002079)1.92131809
106Rigidity (HP:0002063)1.90484437
107Gait ataxia (HP:0002066)1.89532257
108Abnormality of ocular smooth pursuit (HP:0000617)1.88532998
109Degeneration of the lateral corticospinal tracts (HP:0002314)1.87637938
110Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.87637938
111Heterochromia iridis (HP:0001100)1.86409376
112Diminished motivation (HP:0000745)1.86151378
113Focal dystonia (HP:0004373)1.85548387
114Postural tremor (HP:0002174)1.84517740
115Increased circulating renin level (HP:0000848)1.83920377
116Paraplegia (HP:0010550)1.83389393
117Type II lissencephaly (HP:0007260)1.83360284
118Choreoathetosis (HP:0001266)1.83352557
119Medial flaring of the eyebrow (HP:0010747)1.83064164
120Abnormality of saccadic eye movements (HP:0000570)1.81674678
121Megalencephaly (HP:0001355)1.81177989
122Neoplasm of the peripheral nervous system (HP:0100007)1.80595347
123Hyperthyroidism (HP:0000836)1.79229486
124Nephrogenic diabetes insipidus (HP:0009806)1.78773073
125Spastic tetraparesis (HP:0001285)1.77958951

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.50305281
2MAP3K93.71967368
3MAP3K123.46790220
4MAP3K43.32341177
5MAP2K72.76628778
6MINK12.71263293
7MARK12.68784224
8NTRK22.48978930
9PNCK2.40612721
10MAP2K42.39576989
11EPHA42.35596702
12CASK2.28062656
13PAK62.01192216
14ARAF1.97761219
15NTRK11.95866097
16TNIK1.74964052
17KSR21.68782984
18CDK191.68481330
19UHMK11.56123521
20GRK51.54786681
21CDK51.41756994
22MAPK131.33892031
23FES1.33512621
24CAMKK11.32303445
25MAP3K131.31650331
26OXSR11.31177086
27TNK21.28156161
28DAPK21.27873551
29PHKG11.27823531
30PHKG21.27823531
31PLK21.25558595
32PRKCG1.24734512
33STK381.24172992
34CAMKK21.20532032
35CAMK2A1.13853676
36PRKD31.13677185
37RIPK41.13570747
38LMTK21.11812337
39MAP4K21.07554465
40LATS21.06645378
41PAK31.06095532
42KSR11.00862971
43STK390.98333499
44DYRK20.98095054
45SGK2230.97461519
46SGK4940.97461519
47GRK70.96649678
48SIK20.92749157
49TYRO30.90105581
50WNK30.88312860
51CDK140.88294578
52CAMK2B0.86807891
53WNK10.85499104
54CDK180.84604782
55PRPF4B0.84077448
56CDK150.83241888
57PRKCH0.82338392
58CSNK1G20.81018243
59MAP3K20.80509344
60CAMK2G0.78961313
61DAPK10.78653494
62CAMK10.77023336
63PINK10.76344324
64MAPK120.76295908
65MAPKAPK50.75765754
66STK110.75750107
67CAMK2D0.75553877
68CAMK40.73295794
69CAMK1G0.71932435
70CDK11A0.71441365
71SCYL20.67834724
72FER0.67656752
73MAP3K10.67430671
74ADRBK20.67373524
75PRKCE0.65578178
76WNK40.64874422
77SGK20.64371965
78RET0.63656016
79CSNK1A1L0.62216001
80TESK10.60473247
81TAOK20.60402328
82NME10.57494913
83DYRK1A0.56292824
84MUSK0.55926706
85SGK10.53809835
86ERBB30.52597993
87RAF10.51226270
88BCR0.49953444
89ADRBK10.49808974
90ROCK20.49206958
91RPS6KA30.48667906
92ALK0.48624603
93AKT30.48083491
94CSNK1G30.48004229
95CSNK1G10.47918367
96BRAF0.46960653
97MAPK100.46873273
98NEK60.46797129
99SGK30.46455641
100LIMK10.46434907
101CDC42BPA0.45262445
102IRAK20.43589090
103PRKCZ0.42253372
104PKN10.42050012
105PDPK10.41231412
106MARK20.40720435
107PRKACA0.39650112
108BMPR20.39244179
109FYN0.38848000
110PDK10.38107604
111PRKAA10.37681599
112PRKG10.37171252
113CSNK1D0.36952274
114MAP3K110.34921128
115PRKCA0.34142717
116MAP2K60.33861151
117DAPK30.33014403
118CSNK1A10.30262585
119CSNK1E0.29982516
120PRKCB0.28910045
121CCNB10.28700793
122CDK30.27894206
123FGFR20.27823599

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.23417545
2Synaptic vesicle cycle_Homo sapiens_hsa047213.74810861
3GABAergic synapse_Homo sapiens_hsa047273.17404589
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.76089773
5Morphine addiction_Homo sapiens_hsa050322.56593239
6Olfactory transduction_Homo sapiens_hsa047402.43591338
7Circadian entrainment_Homo sapiens_hsa047132.39678802
8Glutamatergic synapse_Homo sapiens_hsa047242.36006070
9Collecting duct acid secretion_Homo sapiens_hsa049662.32628477
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.26156796
11Long-term potentiation_Homo sapiens_hsa047202.20526492
12Amphetamine addiction_Homo sapiens_hsa050312.19371869
13Taste transduction_Homo sapiens_hsa047422.08326510
14Dopaminergic synapse_Homo sapiens_hsa047282.03539739
15Insulin secretion_Homo sapiens_hsa049111.95317873
16Salivary secretion_Homo sapiens_hsa049701.95262954
17Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.92645372
18Serotonergic synapse_Homo sapiens_hsa047261.90767620
19Cocaine addiction_Homo sapiens_hsa050301.78874940
20Long-term depression_Homo sapiens_hsa047301.78187639
21Oxidative phosphorylation_Homo sapiens_hsa001901.78146044
22Gastric acid secretion_Homo sapiens_hsa049711.75168336
23Cholinergic synapse_Homo sapiens_hsa047251.66711414
24Renin secretion_Homo sapiens_hsa049241.62832519
25Cardiac muscle contraction_Homo sapiens_hsa042601.55792981
26Vibrio cholerae infection_Homo sapiens_hsa051101.54916631
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.50067258
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.44744806
29Parkinsons disease_Homo sapiens_hsa050121.39810420
30Calcium signaling pathway_Homo sapiens_hsa040201.39714595
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.36751042
32Oxytocin signaling pathway_Homo sapiens_hsa049211.35810092
33Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.35324869
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.31421793
35Alzheimers disease_Homo sapiens_hsa050101.25579181
36GnRH signaling pathway_Homo sapiens_hsa049121.23918500
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.21705372
38Gap junction_Homo sapiens_hsa045401.19513233
39cAMP signaling pathway_Homo sapiens_hsa040241.06212170
40Estrogen signaling pathway_Homo sapiens_hsa049151.05430777
41Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.04264602
42Vitamin B6 metabolism_Homo sapiens_hsa007501.02882615
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.00064150
44Type II diabetes mellitus_Homo sapiens_hsa049300.93986620
45Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.91710717
46Type I diabetes mellitus_Homo sapiens_hsa049400.91408838
47Melanogenesis_Homo sapiens_hsa049160.90772111
48Huntingtons disease_Homo sapiens_hsa050160.90667942
49Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87877038
50Dorso-ventral axis formation_Homo sapiens_hsa043200.86777298
51Phototransduction_Homo sapiens_hsa047440.84409077
52Axon guidance_Homo sapiens_hsa043600.81933785
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.79512296
54Thyroid hormone synthesis_Homo sapiens_hsa049180.78667574
55ErbB signaling pathway_Homo sapiens_hsa040120.77438664
56Pancreatic secretion_Homo sapiens_hsa049720.75927109
57Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.72534273
58Oocyte meiosis_Homo sapiens_hsa041140.72500574
59cGMP-PKG signaling pathway_Homo sapiens_hsa040220.72155899
60Glioma_Homo sapiens_hsa052140.66327937
61Nitrogen metabolism_Homo sapiens_hsa009100.65422091
62Dilated cardiomyopathy_Homo sapiens_hsa054140.64009043
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62240385
64Butanoate metabolism_Homo sapiens_hsa006500.61985299
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.61385266
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60734175
67MAPK signaling pathway_Homo sapiens_hsa040100.58526141
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57443027
69Prion diseases_Homo sapiens_hsa050200.54784593
70Regulation of autophagy_Homo sapiens_hsa041400.53719552
71Rheumatoid arthritis_Homo sapiens_hsa053230.53514093
72Alcoholism_Homo sapiens_hsa050340.53458289
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53039241
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52950004
75Bile secretion_Homo sapiens_hsa049760.50160762
76Choline metabolism in cancer_Homo sapiens_hsa052310.47884752
77Fatty acid biosynthesis_Homo sapiens_hsa000610.47762034
78Glucagon signaling pathway_Homo sapiens_hsa049220.45478347
79Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44749049
80Ovarian steroidogenesis_Homo sapiens_hsa049130.44029380
81Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42301804
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42257227
83Ras signaling pathway_Homo sapiens_hsa040140.42027986
84Inositol phosphate metabolism_Homo sapiens_hsa005620.41508908
85Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.40452161
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.35374756
87Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.35143534
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.33541578
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.32523528
90Endocytosis_Homo sapiens_hsa041440.31066794
91Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.31017416
92Insulin signaling pathway_Homo sapiens_hsa049100.29960953
93Phagosome_Homo sapiens_hsa041450.29941779
94Renal cell carcinoma_Homo sapiens_hsa052110.29925113
95VEGF signaling pathway_Homo sapiens_hsa043700.28740055
96Circadian rhythm_Homo sapiens_hsa047100.28300486
97Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.26539014
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.25281353
99AMPK signaling pathway_Homo sapiens_hsa041520.25024027
100Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.23943632
101Rap1 signaling pathway_Homo sapiens_hsa040150.23844056
102Wnt signaling pathway_Homo sapiens_hsa043100.23126691
103Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.22436384
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.21235895
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.21011056
106Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.20079792
107Hippo signaling pathway_Homo sapiens_hsa043900.17264064
108mTOR signaling pathway_Homo sapiens_hsa041500.17216902
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.15693627
110Mineral absorption_Homo sapiens_hsa049780.15631417
111beta-Alanine metabolism_Homo sapiens_hsa004100.14372930
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.14164835

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