ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.95125626
2	L-fucose catabolic process (GO:0042355)	5.26606863
3	fucose catabolic process (GO:0019317)	5.26606863
4	L-fucose metabolic process (GO:0042354)	5.26606863
5	proteasome assembly (GO:0043248)	4.08832382
6	DNA deamination (GO:0045006)	3.82497874
7	water-soluble vitamin biosynthetic process (GO:0042364)	3.70571808
8	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.66197171
9	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.66197171
10	NADH dehydrogenase complex assembly (GO:0010257)	3.66197171
11	protein complex biogenesis (GO:0070271)	3.59252924
12	negative regulation of telomere maintenance (GO:0032205)	3.51066563
13	DNA damage response, detection of DNA damage (GO:0042769)	3.46574832
14	protein-cofactor linkage (GO:0018065)	3.42654484
15	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.39022460
16	ubiquinone biosynthetic process (GO:0006744)	3.38314644
17	response to pheromone (GO:0019236)	3.32749560
18	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.29699629
19	somite development (GO:0061053)	3.24491476
20	nonmotile primary cilium assembly (GO:0035058)	3.23010589
21	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.21298357
22	ATP synthesis coupled proton transport (GO:0015986)	3.21298357
23	sulfation (GO:0051923)	3.19989805
24	mitochondrial respiratory chain complex assembly (GO:0033108)	3.19750851
25	ubiquinone metabolic process (GO:0006743)	3.16926150
26	platelet dense granule organization (GO:0060155)	3.16196779
27	epithelial cilium movement (GO:0003351)	3.10978429
28	positive regulation of oligodendrocyte differentiation (GO:0048714)	3.10587252
29	viral transcription (GO:0019083)	3.06485762
30	GTP biosynthetic process (GO:0006183)	3.03834133
31	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.03416019
32	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.99607529
33	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.99597328
34	translational termination (GO:0006415)	2.99458129
35	pyrimidine nucleobase catabolic process (GO:0006208)	2.97510018
36	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.93298917
37	ribosomal small subunit assembly (GO:0000028)	2.88974956
38	hindbrain development (GO:0030902)	2.86468470
39	indolalkylamine metabolic process (GO:0006586)	2.85648892
40	kidney morphogenesis (GO:0060993)	2.85139898
41	UTP metabolic process (GO:0046051)	2.83022486
42	synaptic transmission, cholinergic (GO:0007271)	2.82861076
43	DNA double-strand break processing (GO:0000729)	2.76103267
44	axon ensheathment in central nervous system (GO:0032291)	2.73993028
45	central nervous system myelination (GO:0022010)	2.73993028
46	positive regulation of gastrulation (GO:2000543)	2.73956467
47	neuron fate determination (GO:0048664)	2.70672916
48	gamma-aminobutyric acid transport (GO:0015812)	2.70364165
49	cell proliferation in forebrain (GO:0021846)	2.69017809
50	regulation of cilium movement (GO:0003352)	2.66249276
51	respiratory chain complex IV assembly (GO:0008535)	2.65473101
52	indole-containing compound catabolic process (GO:0042436)	2.64934923
53	indolalkylamine catabolic process (GO:0046218)	2.64934923
54	tryptophan catabolic process (GO:0006569)	2.64934923
55	nephron epithelium morphogenesis (GO:0072088)	2.64293808
56	nephron tubule morphogenesis (GO:0072078)	2.64293808
57	quinone biosynthetic process (GO:1901663)	2.64224701
58	protein polyglutamylation (GO:0018095)	2.63195103
59	fucosylation (GO:0036065)	2.62912893
60	neural tube formation (GO:0001841)	2.62850552
61	behavioral response to ethanol (GO:0048149)	2.62775645
62	electron transport chain (GO:0022900)	2.62333345
63	nucleobase catabolic process (GO:0046113)	2.61405630
64	neuronal action potential (GO:0019228)	2.61253442
65	detection of light stimulus involved in sensory perception (GO:0050962)	2.60747867
66	detection of light stimulus involved in visual perception (GO:0050908)	2.60747867
67	photoreceptor cell development (GO:0042461)	2.58745524
68	kynurenine metabolic process (GO:0070189)	2.56872957
69	respiratory electron transport chain (GO:0022904)	2.55834109
70	chaperone-mediated protein transport (GO:0072321)	2.55033758
71	cytochrome complex assembly (GO:0017004)	2.53879178
72	auditory behavior (GO:0031223)	2.53649410
73	intracellular protein transmembrane import (GO:0044743)	2.53379924
74	cotranslational protein targeting to membrane (GO:0006613)	2.52182038
75	regulation of mesoderm development (GO:2000380)	2.51150210
76	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.50385828
77	spinal cord motor neuron differentiation (GO:0021522)	2.50127997
78	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.49006992
79	regulation of telomere maintenance (GO:0032204)	2.48449498
80	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	2.47695879
81	somite rostral/caudal axis specification (GO:0032525)	2.47365289
82	retinal cone cell development (GO:0046549)	2.47354487
83	regulation of glucokinase activity (GO:0033131)	2.46622613
84	regulation of hexokinase activity (GO:1903299)	2.46622613
85	preassembly of GPI anchor in ER membrane (GO:0016254)	2.46508123
86	cilium movement (GO:0003341)	2.45569864
87	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.45446458
88	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.45446458
89	protein targeting to ER (GO:0045047)	2.45064588
90	protein neddylation (GO:0045116)	2.44295257
91	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.43553039
92	UTP biosynthetic process (GO:0006228)	2.43390273
93	translational elongation (GO:0006414)	2.42065490
94	rhodopsin mediated signaling pathway (GO:0016056)	2.38439802
95	cilium morphogenesis (GO:0060271)	2.38131694
96	regulation of mesenchymal cell apoptotic process (GO:2001053)	2.37965944
97	primary amino compound metabolic process (GO:1901160)	2.37964889
98	thalamus development (GO:0021794)	2.37080666
99	reciprocal DNA recombination (GO:0035825)	2.37030569
100	reciprocal meiotic recombination (GO:0007131)	2.37030569

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.90320695
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.68446292
3	VDR_22108803_ChIP-Seq_LS180_Human	3.19908572
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.10927273
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.68355777
6	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.43827791
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.28024600
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.26464166
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.18559797
10	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.11606451
11	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.10024663
12	EWS_26573619_Chip-Seq_HEK293_Human	2.09819778
13	FUS_26573619_Chip-Seq_HEK293_Human	2.09666151
14	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.08101014
15	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.00309349
16	IGF1R_20145208_ChIP-Seq_DFB_Human	1.97729421
17	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.96220285
18	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.92728766
19	P300_19829295_ChIP-Seq_ESCs_Human	1.89537928
20	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.86918514
21	TAF15_26573619_Chip-Seq_HEK293_Human	1.80180278
22	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.79529636
23	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.79017677
24	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.73348289
25	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.73201067
26	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.68004613
27	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.67314999
28	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.66918917
29	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.63386553
30	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.61344596
31	RNF2_27304074_Chip-Seq_NSC_Mouse	1.59035751
32	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.56953959
33	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.55264172
34	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.53291945
35	IRF1_19129219_ChIP-ChIP_H3396_Human	1.52186656
36	REST_21632747_ChIP-Seq_MESCs_Mouse	1.50816045
37	TP53_22573176_ChIP-Seq_HFKS_Human	1.50733474
38	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.48833393
39	ER_23166858_ChIP-Seq_MCF-7_Human	1.48244218
40	MYC_18940864_ChIP-ChIP_HL60_Human	1.45761501
41	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.41452714
42	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.40396307
43	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.39283759
44	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.38344890
45	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.38344890
46	BCAT_22108803_ChIP-Seq_LS180_Human	1.37829113
47	NANOG_19829295_ChIP-Seq_ESCs_Human	1.36010274
48	SOX2_19829295_ChIP-Seq_ESCs_Human	1.36010274
49	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.35749058
50	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.30778034
51	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.29411090
52	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.27084946
53	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.25740181
54	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.24610094
55	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.23685742
56	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.23184219
57	CBP_20019798_ChIP-Seq_JUKART_Human	1.23184219
58	AR_25329375_ChIP-Seq_VCAP_Human	1.22550189
59	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.21857161
60	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.21200765
61	AR_21572438_ChIP-Seq_LNCaP_Human	1.20926926
62	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.20837943
63	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.20260079
64	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.19964074
65	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.19612463
66	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.19612463
67	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.18924109
68	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.16650113
69	NCOR_22424771_ChIP-Seq_293T_Human	1.16342240
70	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.16208019
71	SMAD4_21799915_ChIP-Seq_A2780_Human	1.16037237
72	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.15657103
73	STAT3_23295773_ChIP-Seq_U87_Human	1.15289116
74	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.15186268
75	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.15154291
76	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.14973646
77	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.14670003
78	AR_20517297_ChIP-Seq_VCAP_Human	1.13688371
79	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.12544528
80	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.10943753
81	TAF2_19829295_ChIP-Seq_ESCs_Human	1.08845927
82	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.07956247
83	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.07317740
84	TCF4_22108803_ChIP-Seq_LS180_Human	1.07061650
85	TCF4_23295773_ChIP-Seq_U87_Human	1.06960199
86	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.06888086
87	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.06539444
88	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.06430870
89	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.06402642
90	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.05365369
91	HOXB7_26014856_ChIP-Seq_BT474_Human	1.05061979
92	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.03242711
93	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.02483669
94	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.01473708
95	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.00937824
96	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.00776470
97	RUNX2_22187159_ChIP-Seq_PCA_Human	0.99959803
98	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.99461128
99	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.99125251
100	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.98079461

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	3.13809355
2	MP0008877_abnormal_DNA_methylation	2.90196317
3	MP0009379_abnormal_foot_pigmentation	2.71246879
4	MP0003136_yellow_coat_color	2.51241979
5	MP0003283_abnormal_digestive_organ	2.42410864
6	MP0002102_abnormal_ear_morphology	2.42348195
7	MP0002736_abnormal_nociception_after	2.28544797
8	MP0003787_abnormal_imprinting	2.27973102
9	MP0002938_white_spotting	2.19044815
10	MP0005551_abnormal_eye_electrophysiolog	2.16061044
11	MP0003195_calcinosis	2.14662753
12	MP0000566_synostosis	2.00893841
13	MP0001968_abnormal_touch/_nociception	1.99942885
14	MP0002837_dystrophic_cardiac_calcinosis	1.98545995
15	MP0004133_heterotaxia	1.98057235
16	MP0003011_delayed_dark_adaptation	1.95979024
17	MP0004885_abnormal_endolymph	1.91791646
18	MP0004142_abnormal_muscle_tone	1.90315202
19	MP0003646_muscle_fatigue	1.87728702
20	MP0006072_abnormal_retinal_apoptosis	1.86682836
21	MP0002653_abnormal_ependyma_morphology	1.84094592
22	MP0009745_abnormal_behavioral_response	1.82209663
23	MP0005646_abnormal_pituitary_gland	1.82128624
24	MP0001529_abnormal_vocalization	1.78835473
25	MP0004147_increased_porphyrin_level	1.70085335
26	MP0005253_abnormal_eye_physiology	1.70032822
27	MP0003880_abnormal_central_pattern	1.68239062
28	MP0010386_abnormal_urinary_bladder	1.65567670
29	MP0002638_abnormal_pupillary_reflex	1.64615482
30	MP0003122_maternal_imprinting	1.63915326
31	MP0006276_abnormal_autonomic_nervous	1.62920543
32	MP0000631_abnormal_neuroendocrine_gland	1.61994053
33	MP0002272_abnormal_nervous_system	1.60646603
34	MP0008872_abnormal_physiological_respon	1.56053842
35	MP0001986_abnormal_taste_sensitivity	1.53622099
36	MP0009046_muscle_twitch	1.50664936
37	MP0002876_abnormal_thyroid_physiology	1.48281639
38	MP0002735_abnormal_chemical_nociception	1.47734343
39	MP0002277_abnormal_respiratory_mucosa	1.47349023
40	MP0004742_abnormal_vestibular_system	1.46428089
41	MP0002234_abnormal_pharynx_morphology	1.45166725
42	MP0001485_abnormal_pinna_reflex	1.40859082
43	MP0005084_abnormal_gallbladder_morpholo	1.37358961
44	MP0003121_genomic_imprinting	1.36015281
45	MP0001486_abnormal_startle_reflex	1.29897376
46	MP0000372_irregular_coat_pigmentation	1.29199463
47	MP0000569_abnormal_digit_pigmentation	1.28654629
48	MP0005645_abnormal_hypothalamus_physiol	1.27035658
49	MP0000026_abnormal_inner_ear	1.25182621
50	MP0002572_abnormal_emotion/affect_behav	1.24941411
51	MP0002064_seizures	1.23135575
52	MP0001984_abnormal_olfaction	1.22919762
53	MP0002928_abnormal_bile_duct	1.22894481
54	MP0000049_abnormal_middle_ear	1.22879774
55	MP0002163_abnormal_gland_morphology	1.21249747
56	MP0003937_abnormal_limbs/digits/tail_de	1.20771514
57	MP0002557_abnormal_social/conspecific_i	1.20156278
58	MP0002160_abnormal_reproductive_system	1.18432395
59	MP0005195_abnormal_posterior_eye	1.17941912
60	MP0001501_abnormal_sleep_pattern	1.16562468
61	MP0003890_abnormal_embryonic-extraembry	1.16505655
62	MP0008875_abnormal_xenobiotic_pharmacok	1.15437013
63	MP0003119_abnormal_digestive_system	1.15082447
64	MP0001293_anophthalmia	1.14269800
65	MP0002733_abnormal_thermal_nociception	1.13677115
66	MP0000778_abnormal_nervous_system	1.13343048
67	MP0002751_abnormal_autonomic_nervous	1.13193187
68	MP0002067_abnormal_sensory_capabilities	1.12773424
69	MP0008058_abnormal_DNA_repair	1.10569968
70	MP0001970_abnormal_pain_threshold	1.07775636
71	MP0005389_reproductive_system_phenotype	1.05556667
72	MP0004145_abnormal_muscle_electrophysio	1.05084334
73	MP0001905_abnormal_dopamine_level	1.03134113
74	MP0002752_abnormal_somatic_nervous	1.02997832
75	MP0005379_endocrine/exocrine_gland_phen	1.01402810
76	MP0002734_abnormal_mechanical_nocicepti	1.01379007
77	MP0004924_abnormal_behavior	1.01028994
78	MP0005386_behavior/neurological_phenoty	1.01028994
79	MP0003938_abnormal_ear_development	1.00260780
80	MP0008789_abnormal_olfactory_epithelium	0.99692831
81	MP0000383_abnormal_hair_follicle	0.98148882
82	MP0004043_abnormal_pH_regulation	0.97755837
83	MP0002095_abnormal_skin_pigmentation	0.97488957
84	MP0000427_abnormal_hair_cycle	0.95615480
85	MP0003718_maternal_effect	0.95401839
86	MP0002184_abnormal_innervation	0.94961068
87	MP0002063_abnormal_learning/memory/cond	0.92334566
88	MP0001324_abnormal_eye_pigmentation	0.92087203
89	MP0001963_abnormal_hearing_physiology	0.88773468
90	MP0001502_abnormal_circadian_rhythm	0.88354410
91	MP0005423_abnormal_somatic_nervous	0.88120381
92	MP0003635_abnormal_synaptic_transmissio	0.86275927
93	MP0003878_abnormal_ear_physiology	0.85939854
94	MP0005377_hearing/vestibular/ear_phenot	0.85939854
95	MP0005174_abnormal_tail_pigmentation	0.83481802
96	MP0000230_abnormal_systemic_arterial	0.82205131
97	MP0000538_abnormal_urinary_bladder	0.81547248
98	MP0001944_abnormal_pancreas_morphology	0.79774357
99	MP0005391_vision/eye_phenotype	0.77445511
100	MP0000955_abnormal_spinal_cord	0.77396183

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of midbrain morphology (HP:0002418)	4.11528769
2	Molar tooth sign on MRI (HP:0002419)	4.11528769
3	Type II lissencephaly (HP:0007260)	4.03455513
4	Pancreatic cysts (HP:0001737)	3.97832458
5	Congenital stationary night blindness (HP:0007642)	3.83855221
6	Nephronophthisis (HP:0000090)	3.54047787
7	Pancreatic fibrosis (HP:0100732)	3.53449276
8	True hermaphroditism (HP:0010459)	3.52098140
9	Cerebellar dysplasia (HP:0007033)	3.13560029
10	Abnormality of the renal cortex (HP:0011035)	3.09195771
11	Concave nail (HP:0001598)	3.08399873
12	Abnormality of alanine metabolism (HP:0010916)	2.96670550
13	Hyperalaninemia (HP:0003348)	2.96670550
14	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.96670550
15	Abnormality of the renal medulla (HP:0100957)	2.93843809
16	Acute necrotizing encephalopathy (HP:0006965)	2.90902983
17	Renal cortical cysts (HP:0000803)	2.89056642
18	Abolished electroretinogram (ERG) (HP:0000550)	2.86732063
19	Chronic hepatic failure (HP:0100626)	2.75082224
20	Medial flaring of the eyebrow (HP:0010747)	2.73251824
21	Congenital, generalized hypertrichosis (HP:0004540)	2.72418390
22	Pendular nystagmus (HP:0012043)	2.71860917
23	Abnormal number of erythroid precursors (HP:0012131)	2.61872242
24	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.55074751
25	Lissencephaly (HP:0001339)	2.51623872
26	Progressive macrocephaly (HP:0004481)	2.49094949
27	Acute encephalopathy (HP:0006846)	2.47217575
28	Abnormality of the pons (HP:0007361)	2.46009484
29	Focal motor seizures (HP:0011153)	2.43778133
30	Retinal dysplasia (HP:0007973)	2.43288290
31	Abnormal rod and cone electroretinograms (HP:0008323)	2.43215080
32	Mitochondrial inheritance (HP:0001427)	2.42689858
33	Abnormality of cells of the erythroid lineage (HP:0012130)	2.41499945
34	Large for gestational age (HP:0001520)	2.40335325
35	Abnormal mitochondria in muscle tissue (HP:0008316)	2.39448125
36	Bilateral microphthalmos (HP:0007633)	2.38197398
37	Increased corneal curvature (HP:0100692)	2.36920102
38	Keratoconus (HP:0000563)	2.36920102
39	Cystic liver disease (HP:0006706)	2.35200385
40	Hypoplasia of the pons (HP:0012110)	2.34740881
41	Attenuation of retinal blood vessels (HP:0007843)	2.34007017
42	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.33102281
43	Septo-optic dysplasia (HP:0100842)	2.30017301
44	Abnormal drinking behavior (HP:0030082)	2.24458532
45	Polydipsia (HP:0001959)	2.24458532
46	Anencephaly (HP:0002323)	2.24450863
47	Sclerocornea (HP:0000647)	2.23673205
48	Optic disc pallor (HP:0000543)	2.21444899
49	Optic nerve hypoplasia (HP:0000609)	2.19941158
50	Maternal diabetes (HP:0009800)	2.18710087
51	Furrowed tongue (HP:0000221)	2.18412979
52	Decreased central vision (HP:0007663)	2.18002275
53	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.17743356
54	Increased CSF lactate (HP:0002490)	2.17124334
55	Tubular atrophy (HP:0000092)	2.13998109
56	Gait imbalance (HP:0002141)	2.10036195
57	Anophthalmia (HP:0000528)	2.07095172
58	Pachygyria (HP:0001302)	2.06930245
59	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.06081126
60	Abnormality of the labia minora (HP:0012880)	2.04610409
61	Bony spicule pigmentary retinopathy (HP:0007737)	2.04232291
62	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.04084268
63	Colon cancer (HP:0003003)	2.03147817
64	Hepatic necrosis (HP:0002605)	2.02823656
65	Hepatocellular necrosis (HP:0001404)	2.02185584
66	Abnormal respiratory motile cilium morphology (HP:0005938)	2.02170973
67	Abnormal respiratory epithelium morphology (HP:0012253)	2.02170973
68	Increased hepatocellular lipid droplets (HP:0006565)	2.02084265
69	Aplasia/Hypoplasia of the patella (HP:0006498)	2.01400832
70	Congenital primary aphakia (HP:0007707)	2.01144701
71	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.00658308
72	Absent/shortened dynein arms (HP:0200106)	2.00658308
73	Lipid accumulation in hepatocytes (HP:0006561)	2.00600072
74	Inability to walk (HP:0002540)	1.98551238
75	Constricted visual fields (HP:0001133)	1.98006002
76	Chorioretinal atrophy (HP:0000533)	1.95067114
77	Patellar aplasia (HP:0006443)	1.94606753
78	Rib fusion (HP:0000902)	1.91901133
79	Congenital sensorineural hearing impairment (HP:0008527)	1.91270342
80	Severe muscular hypotonia (HP:0006829)	1.91145427
81	Hyperglycinuria (HP:0003108)	1.90038052
82	Congenital hepatic fibrosis (HP:0002612)	1.88362990
83	Hyperglycinemia (HP:0002154)	1.87553900
84	Nephrogenic diabetes insipidus (HP:0009806)	1.85283632
85	Aplasia/hypoplasia of the uterus (HP:0008684)	1.84664720
86	Abnormal biliary tract physiology (HP:0012439)	1.84339140
87	Bile duct proliferation (HP:0001408)	1.84339140
88	Postaxial foot polydactyly (HP:0001830)	1.83833198
89	Male pseudohermaphroditism (HP:0000037)	1.83620590
90	Polyuria (HP:0000103)	1.83223727
91	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.82331137
92	3-Methylglutaconic aciduria (HP:0003535)	1.81099116
93	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.76755329
94	Intestinal atresia (HP:0011100)	1.76203224
95	Partial agenesis of the corpus callosum (HP:0001338)	1.75258307
96	Limb dystonia (HP:0002451)	1.74897904
97	Progressive cerebellar ataxia (HP:0002073)	1.74722834
98	Abnormal respiratory motile cilium physiology (HP:0012261)	1.72358468
99	Cerebral edema (HP:0002181)	1.71970545
100	Tachypnea (HP:0002789)	1.71527931

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.87669385
2	ADRBK2	2.96518329
3	TLK1	2.69355712
4	PINK1	2.64883519
5	GRK1	2.62883972
6	WNK3	2.38424194
7	PNCK	2.32367036
8	ACVR1B	2.18119217
9	BMPR1B	2.17624267
10	TAOK3	2.07227502
11	ZAK	2.05815157
12	TXK	2.02577085
13	WNK4	1.97342816
14	MAP4K2	1.91738634
15	INSRR	1.90874572
16	CASK	1.80192671
17	DYRK2	1.71395282
18	NUAK1	1.70642143
19	TNIK	1.68682751
20	DAPK2	1.63771451
21	MAPK13	1.61985877
22	MAPK15	1.60962068
23	MAP3K4	1.53075989
24	TIE1	1.43373420
25	VRK1	1.36640007
26	MAP2K7	1.36044997
27	OXSR1	1.35650035
28	MARK1	1.28833150
29	NTRK2	1.26855134
30	BCKDK	1.25342786
31	PRKCG	1.22666850
32	ADRBK1	1.21772194
33	PASK	1.19186233
34	MKNK2	1.18332365
35	STK39	1.16570319
36	VRK2	1.11215227
37	FGFR2	1.08447535
38	PLK4	1.07308595
39	WEE1	1.05997705
40	TGFBR1	1.04930134
41	TAF1	1.04556552
42	PAK3	0.97866929
43	NTRK3	0.96268351
44	PRKCE	0.94342942
45	PRKCH	0.91214498
46	CAMKK2	0.89131873
47	STK11	0.81982228
48	DYRK3	0.81640961
49	EPHA4	0.80630957
50	MUSK	0.80452671
51	MKNK1	0.76048511
52	CCNB1	0.75852646
53	CDC7	0.75331729
54	CDK3	0.72735487
55	GRK7	0.70359710
56	NME1	0.68045147
57	PLK2	0.67532665
58	PLK3	0.66736390
59	PHKG2	0.66480124
60	PHKG1	0.66480124
61	STK16	0.65687818
62	EPHB2	0.65667901
63	PRKCQ	0.64661876
64	MAP3K9	0.64114192
65	CSNK1G2	0.63010985
66	CAMK2A	0.62177047
67	PIK3CA	0.59547706
68	CAMK1	0.58165645
69	MINK1	0.57694518
70	PRKACA	0.57664403
71	CSNK1A1	0.56409906
72	MARK3	0.52696480
73	TRIM28	0.50748991
74	STK38L	0.49215360
75	BCR	0.49019407
76	CSNK1G1	0.48598783
77	CHEK2	0.47711569
78	RPS6KA6	0.47521386
79	RPS6KA5	0.47195028
80	PRKCI	0.46817936
81	MAPKAPK3	0.46468244
82	BRSK2	0.45652587
83	KIT	0.45346997
84	CAMK1D	0.44874463
85	PRKCZ	0.43104870
86	MAPKAPK5	0.42369666
87	SGK223	0.42295281
88	SGK494	0.42295281
89	SGK2	0.41495926
90	TSSK6	0.41439145
91	CSNK1G3	0.40036435
92	CAMK2D	0.38794208
93	GRK5	0.38245808
94	PRKCA	0.38205985
95	PLK1	0.38066635
96	IKBKB	0.37406136
97	PRKG1	0.36149209
98	TYRO3	0.35154991
99	CAMK1G	0.34777278
100	MAP2K1	0.34350106

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.09529634
2	Ribosome_Homo sapiens_hsa03010	3.07637425
3	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.70713449
4	Phototransduction_Homo sapiens_hsa04744	2.69606900
5	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.61525768
6	Parkinsons disease_Homo sapiens_hsa05012	2.54008346
7	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.41015928
8	Linoleic acid metabolism_Homo sapiens_hsa00591	2.35404105
9	RNA polymerase_Homo sapiens_hsa03020	2.27521273
10	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.16847906
11	Nitrogen metabolism_Homo sapiens_hsa00910	2.16288153
12	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.11200285
13	Protein export_Homo sapiens_hsa03060	2.09475135
14	Nicotine addiction_Homo sapiens_hsa05033	1.97337694
15	Selenocompound metabolism_Homo sapiens_hsa00450	1.96282020
16	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.83186055
17	One carbon pool by folate_Homo sapiens_hsa00670	1.81009979
18	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.77460758
19	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.76378082
20	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.74611691
21	Huntingtons disease_Homo sapiens_hsa05016	1.68797186
22	Cardiac muscle contraction_Homo sapiens_hsa04260	1.64160190
23	Butanoate metabolism_Homo sapiens_hsa00650	1.64054322
24	Basal transcription factors_Homo sapiens_hsa03022	1.62047583
25	Alzheimers disease_Homo sapiens_hsa05010	1.60760606
26	Fanconi anemia pathway_Homo sapiens_hsa03460	1.53648855
27	Homologous recombination_Homo sapiens_hsa03440	1.51430757
28	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.48156374
29	Ether lipid metabolism_Homo sapiens_hsa00565	1.42773212
30	Tryptophan metabolism_Homo sapiens_hsa00380	1.38763430
31	RNA degradation_Homo sapiens_hsa03018	1.29999119
32	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.26911904
33	Caffeine metabolism_Homo sapiens_hsa00232	1.23069429
34	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.22921489
35	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.21521112
36	Propanoate metabolism_Homo sapiens_hsa00640	1.14275336
37	Taste transduction_Homo sapiens_hsa04742	1.13056714
38	Peroxisome_Homo sapiens_hsa04146	1.10496608
39	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.05194958
40	Chemical carcinogenesis_Homo sapiens_hsa05204	1.04776686
41	Olfactory transduction_Homo sapiens_hsa04740	1.03240017
42	Morphine addiction_Homo sapiens_hsa05032	1.02505832
43	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.01091438
44	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.00146021
45	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.96688284
46	Insulin secretion_Homo sapiens_hsa04911	0.96261152
47	Non-homologous end-joining_Homo sapiens_hsa03450	0.96071851
48	Purine metabolism_Homo sapiens_hsa00230	0.95433255
49	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.94505757
50	Proteasome_Homo sapiens_hsa03050	0.88529134
51	Steroid biosynthesis_Homo sapiens_hsa00100	0.87641188
52	Serotonergic synapse_Homo sapiens_hsa04726	0.86800678
53	Retinol metabolism_Homo sapiens_hsa00830	0.85854246
54	GABAergic synapse_Homo sapiens_hsa04727	0.85135627
55	Sulfur metabolism_Homo sapiens_hsa00920	0.83802357
56	Pyrimidine metabolism_Homo sapiens_hsa00240	0.83411120
57	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.81599547
58	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.79693820
59	beta-Alanine metabolism_Homo sapiens_hsa00410	0.78323656
60	Histidine metabolism_Homo sapiens_hsa00340	0.77778822
61	Sulfur relay system_Homo sapiens_hsa04122	0.74833503
62	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.74342328
63	Fat digestion and absorption_Homo sapiens_hsa04975	0.70866982
64	Circadian entrainment_Homo sapiens_hsa04713	0.69874383
65	Glutamatergic synapse_Homo sapiens_hsa04724	0.68717959
66	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.67780302
67	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.67325671
68	Metabolic pathways_Homo sapiens_hsa01100	0.65053484
69	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.64506690
70	Basal cell carcinoma_Homo sapiens_hsa05217	0.61875539
71	Collecting duct acid secretion_Homo sapiens_hsa04966	0.60026094
72	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.59403302
73	Folate biosynthesis_Homo sapiens_hsa00790	0.59186357
74	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.57738033
75	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.53818172
76	Mineral absorption_Homo sapiens_hsa04978	0.50604741
77	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.49590748
78	Cocaine addiction_Homo sapiens_hsa05030	0.48524226
79	Regulation of autophagy_Homo sapiens_hsa04140	0.48087417
80	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.47825029
81	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.47575321
82	Calcium signaling pathway_Homo sapiens_hsa04020	0.47311277
83	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.46033726
84	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.45898813
85	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.43868143
86	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.43175225
87	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.42412279
88	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.41795228
89	Glycerolipid metabolism_Homo sapiens_hsa00561	0.41289584
90	Fatty acid degradation_Homo sapiens_hsa00071	0.39743516
91	Dopaminergic synapse_Homo sapiens_hsa04728	0.39003810
92	Salivary secretion_Homo sapiens_hsa04970	0.37079997
93	ABC transporters_Homo sapiens_hsa02010	0.35265469
94	Cholinergic synapse_Homo sapiens_hsa04725	0.33174612
95	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.33094240
96	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.32697608
97	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.32280091
98	Nucleotide excision repair_Homo sapiens_hsa03420	0.30551241
99	Hippo signaling pathway_Homo sapiens_hsa04390	0.29765262
100	RNA transport_Homo sapiens_hsa03013	0.29164612

NAP1L6

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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