NAPB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the soluble N-ethyl-maleimide-sensitive fusion attachment protein (SNAP) family. SNAP proteins play a critical role in the docking and fusion of vesicles to target membranes as part of the 20S NSF-SNAP-SNARE complex. This gene encodes the SNAP beta isoform which has been shown to be preferentially expressed in brain tissue. The encoded protein also interacts with the GluR2 alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor subunit C-terminus and may play a role as a chaperone in the molecular processing of the AMPA receptor. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)5.97105106
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.96231541
3vocalization behavior (GO:0071625)5.48302998
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.47559079
5glutamate secretion (GO:0014047)5.44067502
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.27098695
7synaptic vesicle maturation (GO:0016188)5.25079805
8protein localization to synapse (GO:0035418)5.12586179
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.12033194
10locomotory exploration behavior (GO:0035641)4.96388010
11neuron cell-cell adhesion (GO:0007158)4.88887185
12synaptic vesicle docking involved in exocytosis (GO:0016081)4.86951531
13* regulation of synaptic vesicle exocytosis (GO:2000300)4.77735889
14regulation of glutamate receptor signaling pathway (GO:1900449)4.74259565
15regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.64146806
16L-amino acid import (GO:0043092)4.58773321
17neuronal action potential propagation (GO:0019227)4.53760667
18ionotropic glutamate receptor signaling pathway (GO:0035235)4.53393880
19neurotransmitter secretion (GO:0007269)4.51389336
20glutamate receptor signaling pathway (GO:0007215)4.34519863
21gamma-aminobutyric acid signaling pathway (GO:0007214)4.28090203
22* regulation of synaptic vesicle transport (GO:1902803)4.27188200
23cell communication by electrical coupling (GO:0010644)4.23421924
24neurotransmitter-gated ion channel clustering (GO:0072578)4.23274735
25cellular potassium ion homeostasis (GO:0030007)4.22755416
26potassium ion homeostasis (GO:0055075)4.22322545
27exploration behavior (GO:0035640)4.19581072
28cellular sodium ion homeostasis (GO:0006883)4.16501794
29* neuron-neuron synaptic transmission (GO:0007270)4.13899283
30potassium ion import (GO:0010107)4.11206504
31amino acid import (GO:0043090)4.11190005
32positive regulation of synapse maturation (GO:0090129)4.09557966
33regulation of long-term neuronal synaptic plasticity (GO:0048169)4.07970380
34synaptic vesicle endocytosis (GO:0048488)3.99769400
35regulation of neuronal synaptic plasticity (GO:0048168)3.99689072
36neuronal ion channel clustering (GO:0045161)3.96931827
37regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.95831883
38* synaptic transmission, glutamatergic (GO:0035249)3.91943077
39negative regulation of synaptic transmission, GABAergic (GO:0032229)3.87387282
40regulation of excitatory postsynaptic membrane potential (GO:0060079)3.84544705
41neurotransmitter transport (GO:0006836)3.83963170
42long-term memory (GO:0007616)3.79819805
43long-term synaptic potentiation (GO:0060291)3.76949624
44regulation of synapse structural plasticity (GO:0051823)3.75962603
45G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.74230417
46positive regulation of membrane potential (GO:0045838)3.72370735
47regulation of postsynaptic membrane potential (GO:0060078)3.72264945
48layer formation in cerebral cortex (GO:0021819)3.71321883
49axon ensheathment in central nervous system (GO:0032291)3.68997734
50central nervous system myelination (GO:0022010)3.68997734
51positive regulation of dendritic spine development (GO:0060999)3.68091074
52proline transport (GO:0015824)3.67613917
53response to histamine (GO:0034776)3.66558418
54negative regulation of dendrite morphogenesis (GO:0050774)3.64144746
55neuromuscular process controlling balance (GO:0050885)3.63541367
56gamma-aminobutyric acid transport (GO:0015812)3.60593456
57membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.56941960
58positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.56732616
59neuron recognition (GO:0008038)3.54660789
60regulation of synaptic transmission, glutamatergic (GO:0051966)3.52975629
61presynaptic membrane assembly (GO:0097105)3.48164873
62neurotransmitter uptake (GO:0001504)3.46717025
63regulation of synaptic plasticity (GO:0048167)3.46095474
64regulation of neurotransmitter levels (GO:0001505)3.46059024
65regulation of vesicle fusion (GO:0031338)3.43466893
66* regulation of neurotransmitter secretion (GO:0046928)3.42087904
67postsynaptic membrane organization (GO:0001941)3.39261776
68cell communication involved in cardiac conduction (GO:0086065)3.39154351
69regulation of ARF protein signal transduction (GO:0032012)3.38763558
70auditory behavior (GO:0031223)3.35725527
71cerebellar Purkinje cell differentiation (GO:0021702)3.35423921
72positive regulation of neurotransmitter transport (GO:0051590)3.31434365
73behavioral response to cocaine (GO:0048148)3.30347019
74transmission of nerve impulse (GO:0019226)3.29256317
75positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.28390633
76acidic amino acid transport (GO:0015800)3.28235441
77innervation (GO:0060384)3.27271591
78regulation of synapse maturation (GO:0090128)3.26718117
79detection of calcium ion (GO:0005513)3.26562969
80regulation of dendritic spine development (GO:0060998)3.25608029
81positive regulation of neurotransmitter secretion (GO:0001956)3.25526537
82regulation of voltage-gated calcium channel activity (GO:1901385)3.24142953
83neuromuscular synaptic transmission (GO:0007274)3.24020412
84dendritic spine morphogenesis (GO:0060997)3.23951340
85behavioral defense response (GO:0002209)3.23591276
86behavioral fear response (GO:0001662)3.23591276
87presynaptic membrane organization (GO:0097090)3.23071219
88membrane hyperpolarization (GO:0060081)3.22785510
89positive regulation of synaptic transmission, GABAergic (GO:0032230)3.22011711
90activation of protein kinase A activity (GO:0034199)3.20912288
91regulation of dendritic spine morphogenesis (GO:0061001)3.20686362
92* regulation of neurotransmitter transport (GO:0051588)3.20050578
93membrane depolarization (GO:0051899)3.19586213
94neuromuscular process controlling posture (GO:0050884)3.19104308
95sodium ion export (GO:0071436)3.18746036
96synapse assembly (GO:0007416)3.17325225
97synaptic vesicle transport (GO:0048489)3.16435677
98establishment of synaptic vesicle localization (GO:0097480)3.16435677
99negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.14651534
100mating behavior (GO:0007617)3.14190385
101membrane depolarization during action potential (GO:0086010)3.13900636
102* synaptic transmission (GO:0007268)3.13362536
103vesicle docking involved in exocytosis (GO:0006904)3.13271525
104fear response (GO:0042596)3.11383116
105positive regulation of synaptic transmission (GO:0050806)3.10404661
106axonal fasciculation (GO:0007413)3.09252321
107learning (GO:0007612)3.08174545
108long term synaptic depression (GO:0060292)3.07423322
109G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.06767889
110cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.06644892
111neuromuscular process (GO:0050905)3.06474810
112startle response (GO:0001964)3.05240561
113cell differentiation in hindbrain (GO:0021533)3.02678734
114establishment of mitochondrion localization (GO:0051654)3.02017973
115regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.00311191
116dendritic spine organization (GO:0097061)2.99546928
117cerebellar granule cell differentiation (GO:0021707)2.97526078
118* regulation of synaptic transmission (GO:0050804)2.97180867
119striatum development (GO:0021756)2.97098156
120positive regulation of dendritic spine morphogenesis (GO:0061003)2.96866927
121response to auditory stimulus (GO:0010996)2.96116077
122vesicle transport along microtubule (GO:0047496)2.92420296
123prepulse inhibition (GO:0060134)2.91116331
124positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.89552622
125regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.89229903
126regulation of synaptic transmission, GABAergic (GO:0032228)2.89222190

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.88777474
2GBX2_23144817_ChIP-Seq_PC3_Human4.08505129
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.16791783
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.05338573
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.02777473
6REST_21632747_ChIP-Seq_MESCs_Mouse2.79269822
7SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.61651834
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.60877468
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.60877468
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.58602483
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.54014085
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.46178221
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.44631607
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.42259526
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.39309676
16RARB_27405468_Chip-Seq_BRAIN_Mouse2.35835661
17TAF15_26573619_Chip-Seq_HEK293_Human2.33421423
18DROSHA_22980978_ChIP-Seq_HELA_Human2.27521773
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.27373093
20* REST_18959480_ChIP-ChIP_MESCs_Mouse2.23823239
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.16672929
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.14312016
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.13232027
24CTBP2_25329375_ChIP-Seq_LNCAP_Human2.07588104
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.07422747
26IKZF1_21737484_ChIP-ChIP_HCT116_Human2.04054434
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.98635652
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.96428029
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.93049106
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.92934564
31AR_21572438_ChIP-Seq_LNCaP_Human1.89853105
32SMAD4_21799915_ChIP-Seq_A2780_Human1.85821310
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.85092584
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.80618731
35THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.75812868
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64939519
37* P300_19829295_ChIP-Seq_ESCs_Human1.64652237
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63818300
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58977225
40MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.52530969
41BMI1_23680149_ChIP-Seq_NPCS_Mouse1.50232327
42SMAD_19615063_ChIP-ChIP_OVARY_Human1.42862120
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.41796257
44NR3C1_23031785_ChIP-Seq_PC12_Mouse1.41317348
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.41192183
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40853064
47AR_25329375_ChIP-Seq_VCAP_Human1.40553905
48IGF1R_20145208_ChIP-Seq_DFB_Human1.39138001
49EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38259311
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38125602
51ZFP281_18757296_ChIP-ChIP_E14_Mouse1.37340482
52PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36098335
53SOX2_21211035_ChIP-Seq_LN229_Gbm1.35367252
54CBX2_27304074_Chip-Seq_ESCs_Mouse1.35277645
55ZNF274_21170338_ChIP-Seq_K562_Hela1.35133695
56PIAS1_25552417_ChIP-Seq_VCAP_Human1.34422584
57ERG_21242973_ChIP-ChIP_JURKAT_Human1.32880823
58FUS_26573619_Chip-Seq_HEK293_Human1.32733731
59STAT3_23295773_ChIP-Seq_U87_Human1.31059254
60VDR_22108803_ChIP-Seq_LS180_Human1.30799317
61OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30610470
62RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.29687346
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26113754
64RNF2_27304074_Chip-Seq_NSC_Mouse1.22239783
65P53_22127205_ChIP-Seq_FIBROBLAST_Human1.20574811
66TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19739989
67RING1B_27294783_Chip-Seq_ESCs_Mouse1.18998733
68TCF4_23295773_ChIP-Seq_U87_Human1.18977445
69KDM2B_26808549_Chip-Seq_K562_Human1.18594134
70AR_19668381_ChIP-Seq_PC3_Human1.18444601
71RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.18065845
72UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13961629
73AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11729501
74TET1_21490601_ChIP-Seq_MESCs_Mouse1.11324663
75ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.11064380
76PRDM14_20953172_ChIP-Seq_ESCs_Human1.09088544
77CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07897234
78GATA1_26923725_Chip-Seq_HPCs_Mouse1.06691317
79RUNX2_22187159_ChIP-Seq_PCA_Human1.05524518
80WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.05123497
81ARNT_22903824_ChIP-Seq_MCF-7_Human1.05041494
82MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04796337
83EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.04685188
84ER_23166858_ChIP-Seq_MCF-7_Human1.04586012
85YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03296804
86JUN_21703547_ChIP-Seq_K562_Human1.02691961
87ZFP281_27345836_Chip-Seq_ESCs_Mouse1.00760097
88BCAT_22108803_ChIP-Seq_LS180_Human1.00073159
89CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99739416
90ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98848617
91TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98837206
92OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.98236074
93WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98012269
94NANOG_18555785_Chip-Seq_ESCs_Mouse0.97140807
95AHR_22903824_ChIP-Seq_MCF-7_Human0.96842058
96DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96771239
97NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96503851
98PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95932369
99RING1B_27294783_Chip-Seq_NPCs_Mouse0.95657694
100TP53_16413492_ChIP-PET_HCT116_Human0.92728472
101RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.92716918
102SMAD3_21741376_ChIP-Seq_ESCs_Human0.92250032
103TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92146607
104POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.91824869
105TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91824869
106CTNNB1_20460455_ChIP-Seq_HCT116_Human0.91035800
107SMAD3_21741376_ChIP-Seq_HESCs_Human0.90299510
108TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90069873
109SMAD4_21741376_ChIP-Seq_HESCs_Human0.89472095
110CTCF_27219007_Chip-Seq_Bcells_Human0.88911543
111CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.87473493
112KDM2B_26808549_Chip-Seq_REH_Human0.87213564
113FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.87168290
114LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85439650
115SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.84949623
116DPY_21335234_ChIP-Seq_ESCs_Mouse0.81948885
117SOX9_26525672_Chip-Seq_HEART_Mouse0.81844254
118GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81567344
119TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.77957910
120SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.77338919
121SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.76689997

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.83452105
2MP0003880_abnormal_central_pattern5.23316938
3MP0003635_abnormal_synaptic_transmissio4.06802744
4MP0004270_analgesia3.48031897
5MP0009745_abnormal_behavioral_response3.43559171
6MP0009046_muscle_twitch3.34634113
7MP0001968_abnormal_touch/_nociception3.27724432
8MP0002063_abnormal_learning/memory/cond3.26606279
9MP0002064_seizures3.24039778
10MP0002572_abnormal_emotion/affect_behav2.84331495
11MP0002272_abnormal_nervous_system2.73426513
12MP0002734_abnormal_mechanical_nocicepti2.68561362
13MP0002736_abnormal_nociception_after2.68408443
14MP0002822_catalepsy2.66078653
15MP0001486_abnormal_startle_reflex2.51855661
16MP0002735_abnormal_chemical_nociception2.50317254
17MP0005423_abnormal_somatic_nervous2.49404208
18MP0001501_abnormal_sleep_pattern2.46749441
19MP0001440_abnormal_grooming_behavior2.24016461
20MP0002067_abnormal_sensory_capabilities2.17505276
21MP0006276_abnormal_autonomic_nervous2.08691055
22MP0002733_abnormal_thermal_nociception2.01191304
23MP0001970_abnormal_pain_threshold2.00022672
24MP0001984_abnormal_olfaction1.97944159
25MP0002184_abnormal_innervation1.90358580
26MP0005386_behavior/neurological_phenoty1.83308790
27MP0004924_abnormal_behavior1.83308790
28MP0008569_lethality_at_weaning1.80734849
29MP0005551_abnormal_eye_electrophysiolog1.79607915
30MP0002557_abnormal_social/conspecific_i1.70615443
31MP0001529_abnormal_vocalization1.69709298
32MP0003329_amyloid_beta_deposits1.68370998
33MP0000778_abnormal_nervous_system1.65143262
34MP0004811_abnormal_neuron_physiology1.64680696
35MP0003879_abnormal_hair_cell1.63973103
36MP0005646_abnormal_pituitary_gland1.61065824
37MP0002909_abnormal_adrenal_gland1.60091820
38MP0009780_abnormal_chondrocyte_physiolo1.59302079
39MP0004858_abnormal_nervous_system1.53379562
40MP0001905_abnormal_dopamine_level1.51999888
41MP0001188_hyperpigmentation1.51277466
42MP0003787_abnormal_imprinting1.48161574
43MP0001502_abnormal_circadian_rhythm1.46441043
44MP0000955_abnormal_spinal_cord1.44237998
45MP0010386_abnormal_urinary_bladder1.44204457
46MP0002882_abnormal_neuron_morphology1.43876924
47MP0002066_abnormal_motor_capabilities/c1.39683921
48MP0004142_abnormal_muscle_tone1.36690936
49MP0004147_increased_porphyrin_level1.36410612
50MP0003123_paternal_imprinting1.28377876
51MP0003122_maternal_imprinting1.27397967
52MP0003633_abnormal_nervous_system1.25513795
53MP0002837_dystrophic_cardiac_calcinosis1.23521043
54MP0005645_abnormal_hypothalamus_physiol1.16065678
55MP0002229_neurodegeneration1.15769184
56MP0008872_abnormal_physiological_respon1.13227203
57MP0003631_nervous_system_phenotype1.07859039
58MP0004145_abnormal_muscle_electrophysio1.07400940
59MP0004885_abnormal_endolymph1.07298263
60MP0002090_abnormal_vision1.06911621
61MP0000751_myopathy1.05288770
62MP0005499_abnormal_olfactory_system1.01784153
63MP0005394_taste/olfaction_phenotype1.01784153
64MP0002152_abnormal_brain_morphology1.01476940
65MP0002638_abnormal_pupillary_reflex0.96957645
66MP0008877_abnormal_DNA_methylation0.94721271
67MP0004742_abnormal_vestibular_system0.94056044
68MP0008874_decreased_physiological_sensi0.91176455
69MP0002752_abnormal_somatic_nervous0.90683624
70MP0001348_abnormal_lacrimal_gland0.89970362
71MP0006072_abnormal_retinal_apoptosis0.89546190
72MP0002069_abnormal_eating/drinking_beha0.89402907
73MP0001963_abnormal_hearing_physiology0.89292604
74MP0005535_abnormal_body_temperature0.86481852
75MP0001485_abnormal_pinna_reflex0.86352948
76MP0001986_abnormal_taste_sensitivity0.86075806
77MP0004215_abnormal_myocardial_fiber0.85459511
78MP0000569_abnormal_digit_pigmentation0.84705662
79MP0004233_abnormal_muscle_weight0.84287142
80MP0000013_abnormal_adipose_tissue0.84234111
81MP0003121_genomic_imprinting0.83504546
82MP0004085_abnormal_heartbeat0.80689274
83MP0005253_abnormal_eye_physiology0.78548178
84MP0002876_abnormal_thyroid_physiology0.78265147
85MP0003634_abnormal_glial_cell0.76915056
86MP0004484_altered_response_of0.76548692
87MP0000631_abnormal_neuroendocrine_gland0.74874899
88MP0001177_atelectasis0.74563365
89MP0003632_abnormal_nervous_system0.73113909
90MP0001664_abnormal_digestion0.70542193
91MP0001346_abnormal_lacrimal_gland0.68911112
92MP0000604_amyloidosis0.68725880
93MP0005409_darkened_coat_color0.67658157
94MP0005167_abnormal_blood-brain_barrier0.61345200
95MP0005623_abnormal_meninges_morphology0.56592477
96MP0010768_mortality/aging0.56066972
97MP0000920_abnormal_myelination0.55130138
98MP0003646_muscle_fatigue0.54386794
99MP0001943_abnormal_respiration0.54344359
100MP0003861_abnormal_nervous_system0.53539402
101MP0005195_abnormal_posterior_eye0.53305554
102MP0004130_abnormal_muscle_cell0.51987942
103MP0004043_abnormal_pH_regulation0.51673047
104MP0006292_abnormal_olfactory_placode0.51449741
105MP0003690_abnormal_glial_cell0.50673325
106MP0003137_abnormal_impulse_conducting0.50451585
107MP0000026_abnormal_inner_ear0.49599270
108MP0010769_abnormal_survival0.49324312
109MP0002082_postnatal_lethality0.49278801
110MP0010770_preweaning_lethality0.49278801
111MP0003956_abnormal_body_size0.49159955
112MP0004036_abnormal_muscle_relaxation0.47909357
113MP0003172_abnormal_lysosome_physiology0.47127819
114MP0003075_altered_response_to0.46878942
115MP0001299_abnormal_eye_distance/0.46385017
116MP0003938_abnormal_ear_development0.43835943
117MP0000579_abnormal_nail_morphology0.43633705

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.16112221
2Myokymia (HP:0002411)6.06396479
3Focal seizures (HP:0007359)5.82034296
4Epileptic encephalopathy (HP:0200134)5.55306527
5Visual hallucinations (HP:0002367)5.31447965
6Atonic seizures (HP:0010819)5.31027933
7Febrile seizures (HP:0002373)5.21716009
8Absence seizures (HP:0002121)4.87464136
9Progressive cerebellar ataxia (HP:0002073)4.64929378
10Dialeptic seizures (HP:0011146)4.43052730
11Generalized tonic-clonic seizures (HP:0002069)4.17093174
12Hyperventilation (HP:0002883)3.81767416
13Broad-based gait (HP:0002136)3.51942988
14Action tremor (HP:0002345)3.46594813
15Gaze-evoked nystagmus (HP:0000640)3.46487678
16Truncal ataxia (HP:0002078)3.28651419
17Supranuclear gaze palsy (HP:0000605)3.27398252
18Cerebral hypomyelination (HP:0006808)3.24808267
19Dysdiadochokinesis (HP:0002075)3.19744985
20Poor eye contact (HP:0000817)3.08356444
21Obstructive sleep apnea (HP:0002870)3.05392693
22Amblyopia (HP:0000646)3.04999716
23Depression (HP:0000716)3.03421471
24Annular pancreas (HP:0001734)2.99889509
25Impaired vibration sensation in the lower limbs (HP:0002166)2.94668225
26Tetraplegia (HP:0002445)2.92296557
27Anxiety (HP:0000739)2.89437942
28Dysmetria (HP:0001310)2.87871820
29Epileptiform EEG discharges (HP:0011182)2.87050186
30Abnormal eating behavior (HP:0100738)2.86676866
31Impaired social interactions (HP:0000735)2.82177570
32Abnormal social behavior (HP:0012433)2.82177570
33Urinary bladder sphincter dysfunction (HP:0002839)2.80287890
34Ankle clonus (HP:0011448)2.77913874
35Drooling (HP:0002307)2.77346233
36Excessive salivation (HP:0003781)2.77346233
37Akinesia (HP:0002304)2.76714205
38EEG with generalized epileptiform discharges (HP:0011198)2.70337000
39Congenital stationary night blindness (HP:0007642)2.69819725
40Mutism (HP:0002300)2.69125294
41Progressive inability to walk (HP:0002505)2.66994473
42Postural instability (HP:0002172)2.66661988
43Degeneration of the lateral corticospinal tracts (HP:0002314)2.65641746
44Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.65641746
45Pheochromocytoma (HP:0002666)2.64707298
46Central scotoma (HP:0000603)2.62112034
47Limb dystonia (HP:0002451)2.60813954
48Sleep apnea (HP:0010535)2.60692627
49Absent speech (HP:0001344)2.56014311
50Clonus (HP:0002169)2.54160993
51Impaired smooth pursuit (HP:0007772)2.53889050
52Cerebral inclusion bodies (HP:0100314)2.50818485
53Abnormality of binocular vision (HP:0011514)2.50765308
54Diplopia (HP:0000651)2.50765308
55Scanning speech (HP:0002168)2.50083550
56Inability to walk (HP:0002540)2.46715886
57Hemiparesis (HP:0001269)2.45472074
58Fetal akinesia sequence (HP:0001989)2.45438471
59Gait imbalance (HP:0002141)2.44526313
60Peripheral hypomyelination (HP:0007182)2.43820947
61Bradykinesia (HP:0002067)2.43629597
62Genetic anticipation (HP:0003743)2.40645378
63Polyphagia (HP:0002591)2.40500217
64Dysmetric saccades (HP:0000641)2.38169696
65Termporal pattern (HP:0011008)2.37614815
66Insidious onset (HP:0003587)2.37614815
67Hypsarrhythmia (HP:0002521)2.35824054
68Status epilepticus (HP:0002133)2.35615710
69Neuroendocrine neoplasm (HP:0100634)2.34862292
70Apathy (HP:0000741)2.33908599
71Abnormality of macular pigmentation (HP:0008002)2.32188514
72Urinary urgency (HP:0000012)2.30209433
73Morphological abnormality of the pyramidal tract (HP:0002062)2.29955007
74Abnormality of ocular smooth pursuit (HP:0000617)2.28165549
75Abnormality of the lower motor neuron (HP:0002366)2.27618267
76Neurofibrillary tangles (HP:0002185)2.25369756
77Spastic tetraparesis (HP:0001285)2.24836979
78Spastic gait (HP:0002064)2.24236688
79Amyotrophic lateral sclerosis (HP:0007354)2.23983771
80CNS hypomyelination (HP:0003429)2.19868808
81Generalized myoclonic seizures (HP:0002123)2.17317680
82Torticollis (HP:0000473)2.15359002
83Choreoathetosis (HP:0001266)2.15163830
84Papilledema (HP:0001085)2.13212804
85Diminished motivation (HP:0000745)2.12773922
86Congenital primary aphakia (HP:0007707)2.12637141
87Stereotypic behavior (HP:0000733)2.11580830
88Delusions (HP:0000746)2.08643922
89Focal dystonia (HP:0004373)2.06331511
90Impaired vibratory sensation (HP:0002495)2.04486656
91Abnormality of the corticospinal tract (HP:0002492)2.04034311
92Insomnia (HP:0100785)2.03374194
93Rapidly progressive (HP:0003678)2.00564578
94Medial flaring of the eyebrow (HP:0010747)1.99368980
95Incomplete penetrance (HP:0003829)1.98636067
96Gait ataxia (HP:0002066)1.98189870
97Blue irides (HP:0000635)1.97322023
98Hemiplegia (HP:0002301)1.96824861
99Protruding tongue (HP:0010808)1.95977781
100Lower limb muscle weakness (HP:0007340)1.95954458
101Hypoventilation (HP:0002791)1.94676606
102Specific learning disability (HP:0001328)1.94572531
103Nephrogenic diabetes insipidus (HP:0009806)1.93452710
104Intention tremor (HP:0002080)1.91849816
105Spastic tetraplegia (HP:0002510)1.91646163
106Abnormal hair whorl (HP:0010721)1.91005048
107Increased circulating renin level (HP:0000848)1.89324865
108Ventricular fibrillation (HP:0001663)1.88644589
109Failure to thrive in infancy (HP:0001531)1.86775794
110Abnormality of salivation (HP:0100755)1.86730158
111Memory impairment (HP:0002354)1.86362422
112Abnormality of saccadic eye movements (HP:0000570)1.85560261
113Agitation (HP:0000713)1.84175303
114Split foot (HP:0001839)1.84012531
115Craniofacial dystonia (HP:0012179)1.81372107
116Psychosis (HP:0000709)1.81273332
117Retinal dysplasia (HP:0007973)1.78200657
118Horizontal nystagmus (HP:0000666)1.77794954
119Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.77742144
120Genital tract atresia (HP:0001827)1.77065808
121Megalencephaly (HP:0001355)1.77019958
122Esotropia (HP:0000565)1.75522239
123Paraplegia (HP:0010550)1.74000633
124Rigidity (HP:0002063)1.73846858
125Bundle branch block (HP:0011710)1.73391278
126Vaginal atresia (HP:0000148)1.72743883
127Widely spaced teeth (HP:0000687)1.71895461
128Neuronal loss in central nervous system (HP:0002529)1.70583821
129Heterochromia iridis (HP:0001100)1.70245849

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.23940717
2EPHA43.91961428
3MAP3K93.54030050
4MAP3K43.51775142
5MAP2K73.13671492
6CASK2.94694441
7MAP3K122.80325508
8MINK12.77878336
9MARK12.57538172
10DAPK22.27775986
11MAP2K42.24149112
12RIPK42.23054768
13PAK62.15629671
14PLK21.88552196
15KSR21.87126160
16PNCK1.82703195
17CDK191.81962952
18GRK51.76659548
19NTRK11.71800633
20NTRK21.70590853
21DAPK11.68245284
22ARAF1.59297943
23PRPF4B1.52145440
24CAMKK11.50088171
25KSR11.47799660
26CDK51.43069802
27MAP3K131.29710879
28FES1.27820746
29TNIK1.27471148
30STK381.26849886
31CAMKK21.25488270
32PRKCG1.23622511
33PRKD31.21060790
34MAPK131.20417492
35NME11.17187899
36CAMK2A1.13845415
37RIPK11.06880231
38SIK21.06324534
39OXSR11.04325125
40BMPR21.00110256
41PTK2B0.97085674
42SGK2230.93241240
43SGK4940.93241240
44AKT30.92240275
45UHMK10.90301976
46PHKG10.89526974
47PHKG20.89526974
48CDK140.87726427
49CDK180.87620635
50CAMK2B0.87050222
51CAMK10.85574441
52DYRK1A0.85114758
53CDK150.83967816
54MAP3K20.82998118
55PINK10.81806109
56LATS20.81595173
57SGK20.80592506
58ALK0.80356986
59NEK60.77865348
60RAF10.77438816
61MAPK120.74798591
62CDK11A0.72330741
63STK110.69643572
64PKN10.67214035
65CCNB10.67078235
66CAMK2D0.66760362
67RET0.66676046
68NEK10.66646450
69TNK20.65386986
70PAK30.63397921
71PRKCE0.63371692
72SGK10.62902428
73CSNK1G20.62430765
74LIMK10.62357904
75FGR0.61940787
76MAP3K60.59939121
77FER0.59201165
78PRKCH0.56536298
79BRAF0.55903767
80TYRO30.54974295
81SGK30.54898913
82MAP3K10.54676403
83SIK30.53995078
84GRK70.53921981
85BRSK10.53763522
86MAP3K110.53545175
87FGFR20.51083836
88PDK10.50623141
89LMTK20.48521209
90CAMK2G0.48273360
91MAP2K10.45994873
92PDPK10.43950795
93PRKCZ0.43802791
94RPS6KA30.41152117
95CAMK1G0.40897974
96ADRBK10.40326872
97MAPK100.39997772
98WNK30.39848616
99ROCK20.39269832
100MARK20.38656833
101WNK10.36856860
102TAOK10.36656344
103MAP3K70.35504740
104CAMK40.35311356
105PRKCA0.35234099
106FYN0.33756272
107BCR0.33732957
108DAPK30.32837402
109PDK40.32705278
110PDK30.32705278
111PRKACA0.32550716
112CSNK1D0.30874153
113PRKCB0.29701027
114ERBB20.29022448
115PRKG10.26833192
116MAPKAPK50.26207585
117TESK10.25545779
118MAPK80.25393685
119CSNK1E0.25382250
120RPS6KB10.24450375

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.16966902
2Synaptic vesicle cycle_Homo sapiens_hsa047213.82364688
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.93585848
4GABAergic synapse_Homo sapiens_hsa047272.89316625
5Olfactory transduction_Homo sapiens_hsa047402.71360969
6Circadian entrainment_Homo sapiens_hsa047132.66256343
7Morphine addiction_Homo sapiens_hsa050322.65881990
8Long-term potentiation_Homo sapiens_hsa047202.57698416
9Glutamatergic synapse_Homo sapiens_hsa047242.50730657
10Amphetamine addiction_Homo sapiens_hsa050312.43066307
11Salivary secretion_Homo sapiens_hsa049702.19843009
12Collecting duct acid secretion_Homo sapiens_hsa049662.19322300
13Dopaminergic synapse_Homo sapiens_hsa047282.19122714
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.15909813
15Taste transduction_Homo sapiens_hsa047422.02772793
16Insulin secretion_Homo sapiens_hsa049112.02463905
17Serotonergic synapse_Homo sapiens_hsa047261.87245311
18Cholinergic synapse_Homo sapiens_hsa047251.85633951
19Renin secretion_Homo sapiens_hsa049241.85013171
20Gastric acid secretion_Homo sapiens_hsa049711.75051651
21Long-term depression_Homo sapiens_hsa047301.70953165
22Phototransduction_Homo sapiens_hsa047441.69808409
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.69654593
24Oxytocin signaling pathway_Homo sapiens_hsa049211.61917101
25Calcium signaling pathway_Homo sapiens_hsa040201.61181076
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.52972610
27Cocaine addiction_Homo sapiens_hsa050301.52531162
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.40207329
29GnRH signaling pathway_Homo sapiens_hsa049121.35389326
30Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.32692576
31Vibrio cholerae infection_Homo sapiens_hsa051101.27978603
32Gap junction_Homo sapiens_hsa045401.26796984
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.25630185
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.23823087
35Cardiac muscle contraction_Homo sapiens_hsa042601.19553588
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.17844154
37Vitamin B6 metabolism_Homo sapiens_hsa007501.17135892
38cAMP signaling pathway_Homo sapiens_hsa040241.16909174
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.13059067
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.10176066
41cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00573959
42Estrogen signaling pathway_Homo sapiens_hsa049151.00308360
43Type II diabetes mellitus_Homo sapiens_hsa049301.00286523
44Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.97510625
45Vascular smooth muscle contraction_Homo sapiens_hsa042700.92572597
46Glioma_Homo sapiens_hsa052140.91841792
47ErbB signaling pathway_Homo sapiens_hsa040120.89412041
48Axon guidance_Homo sapiens_hsa043600.88961739
49Oxidative phosphorylation_Homo sapiens_hsa001900.88821822
50Melanogenesis_Homo sapiens_hsa049160.87774572
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81524053
52Pancreatic secretion_Homo sapiens_hsa049720.81421053
53Alzheimers disease_Homo sapiens_hsa050100.81129643
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79696176
55Oocyte meiosis_Homo sapiens_hsa041140.79103002
56Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.73924748
57Thyroid hormone synthesis_Homo sapiens_hsa049180.66901164
58Dilated cardiomyopathy_Homo sapiens_hsa054140.66328267
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.65396093
60Dorso-ventral axis formation_Homo sapiens_hsa043200.65036045
61MAPK signaling pathway_Homo sapiens_hsa040100.62241901
62Parkinsons disease_Homo sapiens_hsa050120.60932629
63Circadian rhythm_Homo sapiens_hsa047100.60766033
64Choline metabolism in cancer_Homo sapiens_hsa052310.60338000
65Glucagon signaling pathway_Homo sapiens_hsa049220.56045837
66Inositol phosphate metabolism_Homo sapiens_hsa005620.54130722
67Type I diabetes mellitus_Homo sapiens_hsa049400.53616101
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51829786
69Alcoholism_Homo sapiens_hsa050340.51368293
70Ras signaling pathway_Homo sapiens_hsa040140.49803822
71Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.49699021
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49062826
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48382662
74Rheumatoid arthritis_Homo sapiens_hsa053230.47226739
75VEGF signaling pathway_Homo sapiens_hsa043700.44939362
76African trypanosomiasis_Homo sapiens_hsa051430.43666498
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.43101835
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41956126
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.40943005
80Rap1 signaling pathway_Homo sapiens_hsa040150.39134265
81Mineral absorption_Homo sapiens_hsa049780.38366089
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38067137
83Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37410259
84Huntingtons disease_Homo sapiens_hsa050160.37005669
85mTOR signaling pathway_Homo sapiens_hsa041500.36490167
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35592354
87Arginine biosynthesis_Homo sapiens_hsa002200.33732725
88Bile secretion_Homo sapiens_hsa049760.32847191
89Endocytosis_Homo sapiens_hsa041440.31883602
90Arginine and proline metabolism_Homo sapiens_hsa003300.31740132
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31228803
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31211779
93Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31133858
94Fatty acid biosynthesis_Homo sapiens_hsa000610.31106560
95Insulin signaling pathway_Homo sapiens_hsa049100.30930129
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.30692555
97Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30547181
98Prion diseases_Homo sapiens_hsa050200.30409630
99Wnt signaling pathway_Homo sapiens_hsa043100.29210577
100Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.26093986
101Ovarian steroidogenesis_Homo sapiens_hsa049130.25619455
102AMPK signaling pathway_Homo sapiens_hsa041520.25308115
103Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.25280535
104Renal cell carcinoma_Homo sapiens_hsa052110.25225760
105Regulation of autophagy_Homo sapiens_hsa041400.24881285
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.23607789
107Phagosome_Homo sapiens_hsa041450.23328242
108Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.22602003
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.19467430
110Histidine metabolism_Homo sapiens_hsa003400.17144347
111beta-Alanine metabolism_Homo sapiens_hsa004100.14192307
112Tight junction_Homo sapiens_hsa045300.14161568
113Hippo signaling pathway_Homo sapiens_hsa043900.14094463
114Ether lipid metabolism_Homo sapiens_hsa005650.13688153

Most similar genes based on co-expression Upload to Enrichr

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