NAPEPLD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: NAPEPLD is a phospholipase D type enzyme that catalyzes the release of N-acylethanolamine (NAE) from N-acyl-phosphatidylethanolamine (NAPE) in the second step of the biosynthesis of N-acylethanolamine (Okamoto et al., 2004 [PubMed 14634025]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)4.27794170
2cellular potassium ion homeostasis (GO:0030007)4.27434062
3C4-dicarboxylate transport (GO:0015740)3.83406289
4sodium ion export (GO:0071436)3.70944879
5serotonin metabolic process (GO:0042428)3.59505797
6epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.57144353
7presynaptic membrane assembly (GO:0097105)3.56270409
8cellular sodium ion homeostasis (GO:0006883)3.54732222
9neurotransmitter secretion (GO:0007269)3.54342505
10detection of calcium ion (GO:0005513)3.51713537
11L-amino acid import (GO:0043092)3.51171759
12axon ensheathment in central nervous system (GO:0032291)3.43960289
13central nervous system myelination (GO:0022010)3.43960289
14potassium ion import (GO:0010107)3.40439827
15gamma-aminobutyric acid transport (GO:0015812)3.40207731
16response to pheromone (GO:0019236)3.36297379
17piRNA metabolic process (GO:0034587)3.34774678
18vocalization behavior (GO:0071625)3.31909044
19motile cilium assembly (GO:0044458)3.31017534
20primary amino compound metabolic process (GO:1901160)3.30425230
21positive regulation of cell cycle checkpoint (GO:1901978)3.28089297
22neurotransmitter uptake (GO:0001504)3.26001163
23proline transport (GO:0015824)3.24117688
24regulation of protein glycosylation (GO:0060049)3.13319239
25cerebellar granule cell differentiation (GO:0021707)3.13031724
26neurotransmitter transport (GO:0006836)3.12747953
27epithelial cilium movement (GO:0003351)3.12300847
28auditory behavior (GO:0031223)3.11538158
29presynaptic membrane organization (GO:0097090)3.10696124
30neurotransmitter catabolic process (GO:0042135)3.10621262
31regulation of long-term neuronal synaptic plasticity (GO:0048169)3.07193006
32regulation of neuronal synaptic plasticity (GO:0048168)3.06053153
33regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.03232091
34cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.01960691
35regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.01309046
36male meiosis (GO:0007140)3.01288905
37establishment of mitochondrion localization (GO:0051654)3.00358705
38response to redox state (GO:0051775)2.92307697
39monoubiquitinated protein deubiquitination (GO:0035520)2.90282356
40startle response (GO:0001964)2.87358188
41regulation of neurotransmitter levels (GO:0001505)2.87120047
42DNA methylation involved in gamete generation (GO:0043046)2.86490708
43cilium movement (GO:0003341)2.86153648
44neuronal action potential propagation (GO:0019227)2.86083637
45regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.85268166
46potassium ion homeostasis (GO:0055075)2.85198547
47positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.85096108
48negative regulation of neurotransmitter transport (GO:0051589)2.84309059
49embryonic retina morphogenesis in camera-type eye (GO:0060059)2.83933595
50negative regulation of cytosolic calcium ion concentration (GO:0051481)2.82533256
51regulation of spindle checkpoint (GO:0090231)2.82033839
52negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.80293282
53auditory receptor cell stereocilium organization (GO:0060088)2.79985375
54regulation of neurotransmitter secretion (GO:0046928)2.79108064
55neurotransmitter-gated ion channel clustering (GO:0072578)2.79087325
56regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.77042894
57regulation of synaptic vesicle exocytosis (GO:2000300)2.76062524
58righting reflex (GO:0060013)2.74498259
59fusion of sperm to egg plasma membrane (GO:0007342)2.74094272
60transmission of nerve impulse (GO:0019226)2.72941364
61negative regulation of neurotransmitter secretion (GO:0046929)2.72915684
62acidic amino acid transport (GO:0015800)2.72557672
63axonemal dynein complex assembly (GO:0070286)2.71206126
64polyketide metabolic process (GO:0030638)2.70894527
65doxorubicin metabolic process (GO:0044598)2.70894527
66daunorubicin metabolic process (GO:0044597)2.70894527
67regulation of neurotransmitter transport (GO:0051588)2.70388639
68inner ear receptor stereocilium organization (GO:0060122)2.69969381
69cellular potassium ion transport (GO:0071804)2.69910806
70potassium ion transmembrane transport (GO:0071805)2.69910806
71regulation of cell communication by electrical coupling (GO:0010649)2.68942646
72regulation of excitatory postsynaptic membrane potential (GO:0060079)2.67522784
73neuron remodeling (GO:0016322)2.65813392
74positive regulation of action potential (GO:0045760)2.65262918
75regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.65173999
76relaxation of cardiac muscle (GO:0055119)2.58847730
77Golgi to endosome transport (GO:0006895)2.58596662
78cellular ketone body metabolic process (GO:0046950)2.58538001
79neuronal action potential (GO:0019228)2.58302918
80apical protein localization (GO:0045176)2.58195648
81long-chain fatty acid biosynthetic process (GO:0042759)2.57912841
82response to histamine (GO:0034776)2.57707911
83regulation of glutamate receptor signaling pathway (GO:1900449)2.57655555
84potassium ion transport (GO:0006813)2.57631447
85urinary tract smooth muscle contraction (GO:0014848)2.57240059
86regulation of cilium movement (GO:0003352)2.56523735
87detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.56261614
88positive regulation of membrane potential (GO:0045838)2.56207984
89sleep (GO:0030431)2.56186881
90protein localization to synapse (GO:0035418)2.56111974
91positive regulation of synaptic transmission, GABAergic (GO:0032230)2.55616924
92glycosphingolipid biosynthetic process (GO:0006688)2.55544408
93regulation of dendritic spine development (GO:0060998)2.55463503
94synaptic vesicle endocytosis (GO:0048488)2.54167735
95protein localization to cilium (GO:0061512)2.53527811
96regulation of short-term neuronal synaptic plasticity (GO:0048172)2.53520022
97multicellular organism reproduction (GO:0032504)2.52590693
98positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.51911582
99sodium ion homeostasis (GO:0055078)2.51697563
100protein import into peroxisome matrix (GO:0016558)2.51626447
101cell communication involved in cardiac conduction (GO:0086065)2.51308986
102mitotic sister chromatid cohesion (GO:0007064)2.51161638
103synaptic transmission (GO:0007268)2.51071248
104amino acid import (GO:0043090)2.50669986
105ionotropic glutamate receptor signaling pathway (GO:0035235)2.50462153
106gamma-aminobutyric acid signaling pathway (GO:0007214)2.50330411
107regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.49662790
108synaptic vesicle docking involved in exocytosis (GO:0016081)2.48747755
109positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.48436556
110locomotory exploration behavior (GO:0035641)2.48347565
111astrocyte development (GO:0014002)2.48173507
112regulation of female receptivity (GO:0045924)2.47513228
113regulation of postsynaptic membrane potential (GO:0060078)2.47186456
114exploration behavior (GO:0035640)2.46415324
115L-glutamate transport (GO:0015813)2.45921719
116negative regulation of synaptic transmission, GABAergic (GO:0032229)2.44400011
117positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.43928367
118positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.41920029
119glycine transport (GO:0015816)2.41603477
120plasma membrane fusion (GO:0045026)2.40589633
121calcium ion import (GO:0070509)2.39243116
122cerebellar Purkinje cell differentiation (GO:0021702)2.38995889
123neuron cell-cell adhesion (GO:0007158)2.38761462
124lateral sprouting from an epithelium (GO:0060601)2.38578703
125negative regulation of meiotic cell cycle (GO:0051447)2.36655381
126response to methylmercury (GO:0051597)2.33946980
127membrane depolarization during action potential (GO:0086010)2.33380020
128negative regulation of meiosis (GO:0045835)2.31463893
129synaptic transmission, glutamatergic (GO:0035249)2.30559844
130calcium ion-dependent exocytosis (GO:0017156)2.28971084
131membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.28179917
132maintenance of protein location in nucleus (GO:0051457)2.28082244
133regulation of mitotic spindle checkpoint (GO:1903504)2.27728305
134regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.27728305
135spermatid development (GO:0007286)2.27517966
136regulation of synaptic vesicle transport (GO:1902803)2.27127220
137intestinal epithelial cell development (GO:0060576)2.26685247
138glutamate secretion (GO:0014047)2.25206374
139mechanosensory behavior (GO:0007638)2.24946130
140long term synaptic depression (GO:0060292)2.24318795
141mitochondrion transport along microtubule (GO:0047497)2.24309282
142establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.24309282
143glutamate receptor signaling pathway (GO:0007215)2.23487336
144cochlea development (GO:0090102)2.21951419
145synaptic vesicle exocytosis (GO:0016079)2.21944271
146intraciliary transport (GO:0042073)2.20962274
147asymmetric protein localization (GO:0008105)2.20465157
148synaptic vesicle maturation (GO:0016188)2.19888265
149positive regulation of meiotic cell cycle (GO:0051446)2.19052302
150regulation of somitogenesis (GO:0014807)2.18253828
151ventricular system development (GO:0021591)2.18161673
152sperm capacitation (GO:0048240)2.17938642
153regulation of cAMP-dependent protein kinase activity (GO:2000479)2.16013396
154innervation (GO:0060384)2.14492559
155postsynaptic membrane organization (GO:0001941)2.14319969
156synaptonemal complex organization (GO:0070193)2.14232499
157long-term synaptic potentiation (GO:0060291)2.12301638
158spinal cord motor neuron differentiation (GO:0021522)2.12234407
159negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.11501039
160sperm motility (GO:0030317)2.11245185
161neuron-neuron synaptic transmission (GO:0007270)2.11032699

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.62906586
2GBX2_23144817_ChIP-Seq_PC3_Human3.71272931
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.36171058
4ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.71077524
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.68714160
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.13337007
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.09640995
8SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.04064510
9FUS_26573619_Chip-Seq_HEK293_Human2.01336322
10PCGF2_27294783_Chip-Seq_ESCs_Mouse1.98228111
11CDX2_19796622_ChIP-Seq_MESCs_Mouse1.86966709
12STAT3_23295773_ChIP-Seq_U87_Human1.86199972
13VDR_22108803_ChIP-Seq_LS180_Human1.84897268
14IGF1R_20145208_ChIP-Seq_DFB_Human1.82607469
15FLI1_27457419_Chip-Seq_LIVER_Mouse1.79958332
16POU3F2_20337985_ChIP-ChIP_501MEL_Human1.79352866
17REST_21632747_ChIP-Seq_MESCs_Mouse1.76574490
18CTBP2_25329375_ChIP-Seq_LNCAP_Human1.75333279
19EWS_26573619_Chip-Seq_HEK293_Human1.71691637
20CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.71229055
21SMAD4_21799915_ChIP-Seq_A2780_Human1.70284864
22SUZ12_27294783_Chip-Seq_NPCs_Mouse1.69367190
23TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.68554414
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.68472201
25AR_21572438_ChIP-Seq_LNCaP_Human1.68339045
26NANOG_18555785_Chip-Seq_ESCs_Mouse1.66395879
27PIAS1_25552417_ChIP-Seq_VCAP_Human1.65896390
28* ER_23166858_ChIP-Seq_MCF-7_Human1.63892996
29GATA1_26923725_Chip-Seq_HPCs_Mouse1.63772344
30HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.62514409
31RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60887077
32TCF4_23295773_ChIP-Seq_U87_Human1.57960261
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.53616933
34SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.53109473
35P300_19829295_ChIP-Seq_ESCs_Human1.52607359
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.51664902
37TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.51519521
38E2F1_18555785_Chip-Seq_ESCs_Mouse1.50958727
39SALL1_21062744_ChIP-ChIP_HESCs_Human1.48767275
40* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48524178
41NFE2_27457419_Chip-Seq_LIVER_Mouse1.47834523
42SMAD3_21741376_ChIP-Seq_EPCs_Human1.46185915
43OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42650468
44RNF2_27304074_Chip-Seq_NSC_Mouse1.41920125
45EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.41799082
46EZH2_27304074_Chip-Seq_ESCs_Mouse1.41730858
47NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.40806787
48CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.39919276
49CBP_20019798_ChIP-Seq_JUKART_Human1.39274027
50IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39274027
51AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.38791204
52P53_22127205_ChIP-Seq_FIBROBLAST_Human1.38751281
53PCGF2_27294783_Chip-Seq_NPCs_Mouse1.37664864
54BCAT_22108803_ChIP-Seq_LS180_Human1.37561238
55STAT3_18555785_Chip-Seq_ESCs_Mouse1.37263752
56RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.37138338
57CMYC_18555785_Chip-Seq_ESCs_Mouse1.36209258
58SUZ12_18555785_Chip-Seq_ESCs_Mouse1.35269195
59TAF15_26573619_Chip-Seq_HEK293_Human1.33686812
60LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33537889
61CBX2_27304074_Chip-Seq_ESCs_Mouse1.32177316
62DROSHA_22980978_ChIP-Seq_HELA_Human1.31156470
63SMAD_19615063_ChIP-ChIP_OVARY_Human1.31080450
64P53_22387025_ChIP-Seq_ESCs_Mouse1.31027987
65MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29431497
66SOX2_18555785_Chip-Seq_ESCs_Mouse1.28671989
67JARID2_20064375_ChIP-Seq_MESCs_Mouse1.28376676
68TCF4_22108803_ChIP-Seq_LS180_Human1.27992162
69BMI1_23680149_ChIP-Seq_NPCS_Mouse1.27587490
70SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.27012812
71P300_18555785_Chip-Seq_ESCs_Mouse1.26139488
72RNF2_27304074_Chip-Seq_ESCs_Mouse1.25495866
73NR3C1_21868756_ChIP-Seq_MCF10A_Human1.25426476
74EED_16625203_ChIP-ChIP_MESCs_Mouse1.21830867
75FOXM1_26456572_ChIP-Seq_MCF-7_Human1.21579519
76TP53_16413492_ChIP-PET_HCT116_Human1.19885411
77SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.18802173
78TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17934175
79EZH2_27294783_Chip-Seq_NPCs_Mouse1.17767343
80PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.17036807
81RUNX2_22187159_ChIP-Seq_PCA_Human1.16484347
82VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.16111010
83CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16021572
84NR3C1_23031785_ChIP-Seq_PC12_Mouse1.15352375
85SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15277369
86YAP1_20516196_ChIP-Seq_MESCs_Mouse1.15011137
87POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14827143
88TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14827143
89NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.14493232
90NRF2_20460467_ChIP-Seq_MEFs_Mouse1.14493232
91KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14356382
92CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14354091
93TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14038640
94UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13937850
95BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.13611098
96KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.13588530
97TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13424224
98CTNNB1_20460455_ChIP-Seq_HCT116_Human1.13105974
99PRDM14_20953172_ChIP-Seq_ESCs_Human1.12739840
100AR_25329375_ChIP-Seq_VCAP_Human1.12653736
101OCT4_18555785_Chip-Seq_ESCs_Mouse1.12570953
102FLI1_21867929_ChIP-Seq_TH2_Mouse1.11964721
103SOX2_21211035_ChIP-Seq_LN229_Gbm1.10619006
104ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10366195
105REST_18959480_ChIP-ChIP_MESCs_Mouse1.10332678
106SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.10231093
107ZNF274_21170338_ChIP-Seq_K562_Hela1.10163086
108MTF2_20144788_ChIP-Seq_MESCs_Mouse1.10121793
109SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.10003336
110SOX9_26525672_Chip-Seq_HEART_Mouse1.09777208
111STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.09413064
112SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.08708322
113MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08384608
114ARNT_22903824_ChIP-Seq_MCF-7_Human1.06396096
115KLF4_18555785_Chip-Seq_ESCs_Mouse1.06239763
116KDM2B_26808549_Chip-Seq_REH_Human1.06208424
117* RARB_27405468_Chip-Seq_BRAIN_Mouse1.05898320
118CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.05862087
119AHR_22903824_ChIP-Seq_MCF-7_Human1.05644327
120TBL1_22424771_ChIP-Seq_293T_Human1.05386741
121LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05318206
122EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.05090024
123RUNX1_27457419_Chip-Seq_LIVER_Mouse1.05030868
124TAL1_26923725_Chip-Seq_HPCs_Mouse1.04984823
125SOX2_19829295_ChIP-Seq_ESCs_Human1.04440758
126NANOG_19829295_ChIP-Seq_ESCs_Human1.04440758
127CDX2_22108803_ChIP-Seq_LS180_Human1.04352298
128RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.03873924

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting3.29568284
2MP0003880_abnormal_central_pattern3.20287620
3MP0004147_increased_porphyrin_level3.04896380
4MP0008877_abnormal_DNA_methylation2.90796650
5MP0000566_synostosis2.65752985
6MP0004859_abnormal_synaptic_plasticity2.58346351
7MP0002163_abnormal_gland_morphology2.47320538
8MP0005257_abnormal_intraocular_pressure2.44035752
9MP0006292_abnormal_olfactory_placode2.35448212
10MP0005670_abnormal_white_adipose2.35363894
11MP0003123_paternal_imprinting2.30259025
12MP0005410_abnormal_fertilization2.23785529
13MP0003121_genomic_imprinting2.17763736
14MP0004885_abnormal_endolymph2.17017615
15MP0005171_absent_coat_pigmentation2.07583016
16MP0005379_endocrine/exocrine_gland_phen2.05755793
17MP0000569_abnormal_digit_pigmentation2.02201646
18MP0005645_abnormal_hypothalamus_physiol2.00370512
19MP0004043_abnormal_pH_regulation1.96877743
20MP0001984_abnormal_olfaction1.94508595
21MP0001529_abnormal_vocalization1.88923332
22MP0004185_abnormal_adipocyte_glucose1.88381761
23MP0003950_abnormal_plasma_membrane1.88066266
24MP0003122_maternal_imprinting1.85053265
25MP0003635_abnormal_synaptic_transmissio1.84163310
26MP0010386_abnormal_urinary_bladder1.75093829
27MP0009046_muscle_twitch1.74319619
28MP0001486_abnormal_startle_reflex1.70253814
29MP0004270_analgesia1.70111217
30MP0002876_abnormal_thyroid_physiology1.64463958
31MP0005085_abnormal_gallbladder_physiolo1.62035613
32MP0002272_abnormal_nervous_system1.61356600
33MP0002572_abnormal_emotion/affect_behav1.58819798
34MP0002064_seizures1.54978504
35MP0001346_abnormal_lacrimal_gland1.54600590
36MP0000013_abnormal_adipose_tissue1.52243168
37MP0002277_abnormal_respiratory_mucosa1.51943980
38MP0000003_abnormal_adipose_tissue1.50566419
39MP0002837_dystrophic_cardiac_calcinosis1.50006007
40MP0005646_abnormal_pituitary_gland1.46489223
41MP0003252_abnormal_bile_duct1.45571252
42MP0003698_abnormal_male_reproductive1.45348669
43MP0009745_abnormal_behavioral_response1.44587226
44MP0001299_abnormal_eye_distance/1.44368957
45MP0004742_abnormal_vestibular_system1.42274951
46MP0001501_abnormal_sleep_pattern1.41702093
47MP0002063_abnormal_learning/memory/cond1.39950671
48MP0002733_abnormal_thermal_nociception1.37506435
49MP0003879_abnormal_hair_cell1.35709021
50MP0002734_abnormal_mechanical_nocicepti1.35422119
51MP0005360_urolithiasis1.29029488
52MP0008872_abnormal_physiological_respon1.28761022
53MP0005666_abnormal_adipose_tissue1.27554782
54MP0008057_abnormal_DNA_replication1.25177014
55MP0003690_abnormal_glial_cell1.23333910
56MP0002067_abnormal_sensory_capabilities1.23161098
57MP0001440_abnormal_grooming_behavior1.19125061
58MP0001664_abnormal_digestion1.18697154
59* MP0003633_abnormal_nervous_system1.17069140
60MP0001968_abnormal_touch/_nociception1.16569344
61MP0003172_abnormal_lysosome_physiology1.15492549
62MP0001929_abnormal_gametogenesis1.14761608
63MP0003890_abnormal_embryonic-extraembry1.13831405
64MP0003283_abnormal_digestive_organ1.13259146
65MP0003195_calcinosis1.11856840
66MP0001849_ear_inflammation1.09514925
67MP0004133_heterotaxia1.09219458
68MP0002653_abnormal_ependyma_morphology1.08765712
69MP0000427_abnormal_hair_cycle1.08506991
70MP0005375_adipose_tissue_phenotype1.08098150
71MP0002735_abnormal_chemical_nociception1.07925501
72MP0005332_abnormal_amino_acid1.07123154
73MP0008875_abnormal_xenobiotic_pharmacok1.06227507
74* MP0003631_nervous_system_phenotype1.03094910
75MP0000778_abnormal_nervous_system1.00634553
76MP0001764_abnormal_homeostasis0.99966328
77MP0001177_atelectasis0.99508056
78MP0002210_abnormal_sex_determination0.98656023
79MP0002736_abnormal_nociception_after0.98356776
80MP0004811_abnormal_neuron_physiology0.97781065
81MP0008995_early_reproductive_senescence0.96987930
82MP0005174_abnormal_tail_pigmentation0.96926206
83MP0009780_abnormal_chondrocyte_physiolo0.96829719
84MP0002138_abnormal_hepatobiliary_system0.96503306
85MP0003632_abnormal_nervous_system0.96116684
86MP0002139_abnormal_hepatobiliary_system0.95466346
87MP0001485_abnormal_pinna_reflex0.95368270
88MP0006072_abnormal_retinal_apoptosis0.95222472
89MP0001756_abnormal_urination0.94182512
90MP0004924_abnormal_behavior0.93764825
91MP0005386_behavior/neurological_phenoty0.93764825
92MP0001970_abnormal_pain_threshold0.92339177
93MP0002557_abnormal_social/conspecific_i0.92125624
94MP0001188_hyperpigmentation0.91814848
95MP0008961_abnormal_basal_metabolism0.90918802
96MP0001986_abnormal_taste_sensitivity0.90718613
97MP0002928_abnormal_bile_duct0.90115328
98MP0002066_abnormal_motor_capabilities/c0.89536942
99MP0004142_abnormal_muscle_tone0.89467606
100MP0004036_abnormal_muscle_relaxation0.88177647
101MP0005636_abnormal_mineral_homeostasis0.87827430
102MP0002822_catalepsy0.87661317
103MP0005253_abnormal_eye_physiology0.87063433
104MP0000631_abnormal_neuroendocrine_gland0.85014041
105MP0002909_abnormal_adrenal_gland0.83945988
106MP0006276_abnormal_autonomic_nervous0.82348157
107MP0001145_abnormal_male_reproductive0.82168824
108MP0001963_abnormal_hearing_physiology0.81769674
109MP0005551_abnormal_eye_electrophysiolog0.81579420
110MP0000920_abnormal_myelination0.81499111
111MP0005187_abnormal_penis_morphology0.80235607
112MP0000955_abnormal_spinal_cord0.79737061
113MP0002184_abnormal_innervation0.77825667
114MP0004484_altered_response_of0.77302316
115MP0005423_abnormal_somatic_nervous0.76860002
116MP0002882_abnormal_neuron_morphology0.76750803
117MP0002638_abnormal_pupillary_reflex0.76471072
118MP0003136_yellow_coat_color0.76427071
119MP0002069_abnormal_eating/drinking_beha0.76181002
120MP0003111_abnormal_nucleus_morphology0.75702470
121MP0010329_abnormal_lipoprotein_level0.75221363
122MP0003937_abnormal_limbs/digits/tail_de0.74649128
123MP0008569_lethality_at_weaning0.74445344
124MP0000230_abnormal_systemic_arterial0.74339953
125MP0004215_abnormal_myocardial_fiber0.74030154
126MP0000639_abnormal_adrenal_gland0.73936313
127MP0004084_abnormal_cardiac_muscle0.72727599
128MP0000538_abnormal_urinary_bladder0.72454602
129MP0003634_abnormal_glial_cell0.71673122
130MP0004233_abnormal_muscle_weight0.71456111
131MP0005084_abnormal_gallbladder_morpholo0.71251674
132MP0000613_abnormal_salivary_gland0.71069373
133MP0000383_abnormal_hair_follicle0.70926221
134MP0002161_abnormal_fertility/fecundity0.70301039
135MP0004019_abnormal_vitamin_homeostasis0.69986910
136MP0002229_neurodegeneration0.69881671
137MP0001502_abnormal_circadian_rhythm0.69768896
138MP0004085_abnormal_heartbeat0.69184475
139MP0001905_abnormal_dopamine_level0.68758000
140MP0004145_abnormal_muscle_electrophysio0.68129200
141MP0002152_abnormal_brain_morphology0.67719582
142MP0001765_abnormal_ion_homeostasis0.67624956
143MP0000653_abnormal_sex_gland0.67190605

Predicted human phenotypes

RankGene SetZ-score
1Action tremor (HP:0002345)4.15838396
2Focal motor seizures (HP:0011153)4.06316703
3Absent/shortened dynein arms (HP:0200106)3.95049786
4Dynein arm defect of respiratory motile cilia (HP:0012255)3.95049786
5Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.86511785
6Hyperventilation (HP:0002883)3.84708580
7Myokymia (HP:0002411)3.33808619
8Epileptic encephalopathy (HP:0200134)3.20042349
9Papilledema (HP:0001085)3.13872534
10Decreased circulating renin level (HP:0003351)2.95615738
11Abnormal respiratory motile cilium physiology (HP:0012261)2.94471114
12Hypokalemic alkalosis (HP:0001949)2.85725874
13Hyperkalemia (HP:0002153)2.80556554
14Dysdiadochokinesis (HP:0002075)2.78392233
15Vertebral arch anomaly (HP:0008438)2.77959950
16Ankle clonus (HP:0011448)2.73575641
17Abnormal ciliary motility (HP:0012262)2.71535887
18Abnormal respiratory epithelium morphology (HP:0012253)2.64977252
19Abnormal respiratory motile cilium morphology (HP:0005938)2.64977252
20Hemiparesis (HP:0001269)2.64167489
21Febrile seizures (HP:0002373)2.62454802
22Papillary thyroid carcinoma (HP:0002895)2.62340666
23Status epilepticus (HP:0002133)2.61371560
24Intention tremor (HP:0002080)2.56574758
25Medial flaring of the eyebrow (HP:0010747)2.55083878
26Unilateral renal agenesis (HP:0000122)2.50315102
27Polydipsia (HP:0001959)2.49283066
28Abnormal drinking behavior (HP:0030082)2.49283066
29Hyperaldosteronism (HP:0000859)2.48480666
30Drooling (HP:0002307)2.41802081
31Chronic bronchitis (HP:0004469)2.40557336
32Epileptiform EEG discharges (HP:0011182)2.36874601
33Congenital sensorineural hearing impairment (HP:0008527)2.35356892
34Hyperactive renin-angiotensin system (HP:0000841)2.35188315
35True hermaphroditism (HP:0010459)2.34942424
36Rhinitis (HP:0012384)2.34776932
37Abnormality of binocular vision (HP:0011514)2.34174741
38Diplopia (HP:0000651)2.34174741
39Poor eye contact (HP:0000817)2.33920836
40Osteomalacia (HP:0002749)2.32750097
41Abnormality of the labia minora (HP:0012880)2.32408312
42Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.26577702
43Abnormal eating behavior (HP:0100738)2.25245296
44Abnormality of renin-angiotensin system (HP:0000847)2.24724023
45Shawl scrotum (HP:0000049)2.24696186
46Volvulus (HP:0002580)2.23237705
47Nephronophthisis (HP:0000090)2.22864345
48Degeneration of the lateral corticospinal tracts (HP:0002314)2.21718502
49Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.21718502
50Pheochromocytoma (HP:0002666)2.21377815
51Widely spaced teeth (HP:0000687)2.20702425
52Duplicated collecting system (HP:0000081)2.20025102
53Hypomagnesemia (HP:0002917)2.18771190
54Polyuria (HP:0000103)2.18500916
55Excessive salivation (HP:0003781)2.16950262
56Nephrogenic diabetes insipidus (HP:0009806)2.15395516
57Hyperglycinuria (HP:0003108)2.14219509
58Metaphyseal dysplasia (HP:0100255)2.14016103
59EEG with generalized epileptiform discharges (HP:0011198)2.11924130
60Alkalosis (HP:0001948)2.11905657
61Hyperphosphatemia (HP:0002905)2.11090712
62Spastic gait (HP:0002064)2.10847036
63Abnormality of the renal cortex (HP:0011035)2.08917757
64Congenital primary aphakia (HP:0007707)2.04271014
65Clonus (HP:0002169)2.02522744
66Abnormality of potassium homeostasis (HP:0011042)2.00352808
67Genital tract atresia (HP:0001827)2.00175417
68Hypsarrhythmia (HP:0002521)1.99359428
69Hypothermia (HP:0002045)1.98989874
70Chromosomal breakage induced by crosslinking agents (HP:0003221)1.98748377
71Tubulointerstitial nephritis (HP:0001970)1.98700396
72Abnormality of macular pigmentation (HP:0008002)1.98115980
73Retinal dysplasia (HP:0007973)1.97836589
74Gait imbalance (HP:0002141)1.97681653
75Abnormal biliary tract morphology (HP:0012440)1.97394600
76Abnormal social behavior (HP:0012433)1.96871895
77Impaired social interactions (HP:0000735)1.96871895
78Absent speech (HP:0001344)1.96852431
79Abnormality of calcium-phosphate metabolism (HP:0100530)1.96667748
80Genetic anticipation (HP:0003743)1.96180374
81Neuroendocrine neoplasm (HP:0100634)1.95866305
82Progressive cerebellar ataxia (HP:0002073)1.95729291
83Pancreatic fibrosis (HP:0100732)1.95310782
84Absent eyebrow (HP:0002223)1.95270908
85Abnormal urine output (HP:0012590)1.94007319
86Abnormal pancreas size (HP:0012094)1.93233195
87Peripheral hypomyelination (HP:0007182)1.90917707
88Vaginal atresia (HP:0000148)1.90635205
89Abnormality of glutamine family amino acid metabolism (HP:0010902)1.89736242
90Dysmetria (HP:0001310)1.89320388
91Hip dysplasia (HP:0001385)1.88867299
92Metabolic alkalosis (HP:0200114)1.86805569
93Abnormality of the renal medulla (HP:0100957)1.85905026
94Poor coordination (HP:0002370)1.85627540
95Abnormality of the renal collecting system (HP:0004742)1.85163494
96Urinary urgency (HP:0000012)1.84331078
97Spastic tetraparesis (HP:0001285)1.84253973
98Confusion (HP:0001289)1.84178400
99Impaired vibration sensation in the lower limbs (HP:0002166)1.82284933
100Truncal ataxia (HP:0002078)1.81148484
101Focal seizures (HP:0007359)1.81122135
102Ketoacidosis (HP:0001993)1.80841667
103Absence seizures (HP:0002121)1.80824626
104Flared iliac wings (HP:0002869)1.80667930
105Dialeptic seizures (HP:0011146)1.80391407
106Abnormality of renal excretion (HP:0011036)1.80363499
107Cerebellar dysplasia (HP:0007033)1.80004050
108Anxiety (HP:0000739)1.78357592
109Urinary bladder sphincter dysfunction (HP:0002839)1.77950380
110Postural instability (HP:0002172)1.77619464
111Hemiplegia (HP:0002301)1.77094399
112Molar tooth sign on MRI (HP:0002419)1.75257495
113Abnormality of midbrain morphology (HP:0002418)1.75257495
114Impaired vibratory sensation (HP:0002495)1.75254954
115Hyperglycemia (HP:0003074)1.75010297
116Bundle branch block (HP:0011710)1.74884595
117Chronic hepatic failure (HP:0100626)1.74445069
118Tubular atrophy (HP:0000092)1.74231027
119Renal salt wasting (HP:0000127)1.74117151
120Hypokalemia (HP:0002900)1.74041424
121Renal cortical cysts (HP:0000803)1.73886298
122Insulin-resistant diabetes mellitus (HP:0000831)1.73831023
123Atonic seizures (HP:0010819)1.73708058
124Pancreatic cysts (HP:0001737)1.73703165
125Abnormality of glycine metabolism (HP:0010895)1.72648804
126Optic nerve hypoplasia (HP:0000609)1.71636498
127Hypoplasia of the fovea (HP:0007750)1.70386615
128Aplasia/Hypoplasia of the fovea (HP:0008060)1.70386615
129Increased circulating renin level (HP:0000848)1.69271436
130Septo-optic dysplasia (HP:0100842)1.69097378
131Gaze-evoked nystagmus (HP:0000640)1.66920466
132Cerebral hypomyelination (HP:0006808)1.66868074
133Abnormal hair whorl (HP:0010721)1.66175252
134Hypoplastic labia majora (HP:0000059)1.63726341
135Generalized tonic-clonic seizures (HP:0002069)1.63053663
136Ectopic anus (HP:0004397)1.62877236
137Chromsome breakage (HP:0040012)1.62214721
138Abnormality of chloride homeostasis (HP:0011422)1.60541514
139Prostate neoplasm (HP:0100787)1.59819565
140Hypoplasia of the capital femoral epiphysis (HP:0003090)1.59715713
141Intestinal atresia (HP:0011100)1.57842836
142Cystic liver disease (HP:0006706)1.57183436
143Birth length less than 3rd percentile (HP:0003561)1.56453582
144Hyperinsulinemic hypoglycemia (HP:0000825)1.56398260
145Ectopic kidney (HP:0000086)1.55909671
146Macroorchidism (HP:0000053)1.55023995
147Type II lissencephaly (HP:0007260)1.54985894
148Neoplasm of the oral cavity (HP:0100649)1.54429872
149Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.54343789
150Protruding tongue (HP:0010808)1.54221059
151Abnormality of the fovea (HP:0000493)1.53146935
152Broad-based gait (HP:0002136)1.51407543
153Muscle fiber splitting (HP:0003555)1.50774724
154Abnormality of the corticospinal tract (HP:0002492)1.50075661
155Urethral obstruction (HP:0000796)1.48991715
156Infertility (HP:0000789)1.46317759
157Absent rod-and cone-mediated responses on ERG (HP:0007688)1.46001347

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.12362144
2NTRK33.99574494
3PRKD33.54822128
4MAP4K23.00313699
5AKT32.84898290
6CDK122.68167423
7CDK82.48847542
8CASK2.40284362
9SIK32.34816082
10DAPK22.21332012
11ACVR1B2.18704693
12MARK12.10475319
13CAMKK22.02589944
14STK391.93620125
15PDK41.81795606
16PDK31.81795606
17PRPF4B1.81193067
18MAPK151.78143737
19CAMK1D1.74489216
20TNIK1.71394191
21WNK11.70431530
22WNK41.66368538
23NTRK21.52486316
24OXSR11.52019712
25BCR1.50455667
26PNCK1.46276290
27INSRR1.45956487
28CAMK1G1.43963298
29STK38L1.43526096
30WNK31.33697729
31FGFR21.33634312
32ERBB31.28072857
33MAP3K41.25089631
34ADRBK21.23780860
35MAP3K121.21805261
36GRK71.21699624
37PHKG11.11675936
38PHKG21.11675936
39CAMKK11.11461515
40PDK21.11099554
41TTK1.10799422
42MAP3K91.10280637
43ICK1.10180244
44CHEK21.09418715
45PASK1.08964838
46CDK31.08682618
47PAK31.08648866
48PRKCE1.06832113
49BMPR21.05326493
50STK381.03831591
51ZAK0.98342688
52NME10.97607752
53EPHA40.96491055
54STK30.96209083
55MAPK130.96056124
56TAOK20.96036405
57TRIM280.95590265
58PRKCG0.95290399
59SGK2230.93767605
60SGK4940.93767605
61CCNB10.93722115
62MAP3K70.92986064
63CDK70.91487663
64PLK20.88902680
65NEK60.88200890
66MKNK20.87223377
67CSNK1E0.86585299
68BRD40.85019479
69PIK3CA0.83264738
70PAK60.82818587
71MAPKAPK50.81708484
72MAP3K20.80485564
73BMPR1B0.80024186
74PBK0.78505795
75SGK30.78412020
76CDC70.77694653
77LATS10.76811770
78DYRK1A0.76644887
79BRSK10.75980824
80MAP2K70.75853264
81PLK30.75755849
82GRK50.75516055
83CAMK10.74874226
84MAP3K130.74380918
85BUB10.72632752
86PINK10.72379026
87NUAK10.72082403
88DMPK0.70838915
89FER0.70587291
90NTRK10.69103728
91UHMK10.68891524
92CSNK1G20.67410642
93MAPK100.64840298
94SCYL20.64506455
95LATS20.63684278
96SGK10.62325658
97CAMK2B0.61692920
98DAPK10.61668698
99PRKCH0.61135215
100GRK10.60956311
101STK110.60736689
102MAP2K40.60325318
103CAMK2A0.59841488
104CAMK2D0.58663092
105CDC42BPA0.58027518
106CDK190.57338456
107TAOK30.56595787
108VRK10.56066436
109ATM0.55984716
110CSNK1A10.55107943
111KSR10.53689821
112EPHA20.51706018
113CHEK10.51630224
114PTK2B0.51373267
115MARK20.50116378
116MET0.50109887
117PDK10.50090521
118SGK20.49995208
119PDPK10.49867911
120BRAF0.49770355
121MAPK70.49243969
122PRKG10.48952142
123BRSK20.47451529
124CAMK40.47385274
125GSK3B0.47297124
126MST40.47237405
127NEK20.46859411
128PRKAA10.46795879
129MINK10.46353123
130CSNK1A1L0.45145680
131PIK3CG0.44845102
132CAMK2G0.43764926
133CDK50.42764367
134PRKD20.42466869
135RPS6KA30.41109689
136MAPKAPK30.40699906
137OBSCN0.40627681
138MAP2K10.40477033
139PRKACB0.40475500
140PRKCA0.39660062
141PRKAA20.39558010
142HIPK20.38916767
143PRKCZ0.38155037
144PRKCB0.37316890
145TRPM70.36336133
146PRKACA0.35291129
147TNK20.35138167
148PKN10.35061588

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.75640406
2Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.47627749
3Synaptic vesicle cycle_Homo sapiens_hsa047212.15589328
4Insulin secretion_Homo sapiens_hsa049112.09868016
5Vitamin B6 metabolism_Homo sapiens_hsa007502.04446746
6Butanoate metabolism_Homo sapiens_hsa006502.02646364
7Basal transcription factors_Homo sapiens_hsa030221.99315250
8* Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.96413366
9Circadian entrainment_Homo sapiens_hsa047131.94747434
10Long-term potentiation_Homo sapiens_hsa047201.91112549
11Collecting duct acid secretion_Homo sapiens_hsa049661.90423943
12Amphetamine addiction_Homo sapiens_hsa050311.89867095
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.83456032
14Taste transduction_Homo sapiens_hsa047421.78336158
15Maturity onset diabetes of the young_Homo sapiens_hsa049501.75906260
16Morphine addiction_Homo sapiens_hsa050321.73888431
17Renin secretion_Homo sapiens_hsa049241.73028826
18GABAergic synapse_Homo sapiens_hsa047271.72932799
19Glutamatergic synapse_Homo sapiens_hsa047241.67370173
20Histidine metabolism_Homo sapiens_hsa003401.67331315
21Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.66280467
22Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.66140157
23Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.63375052
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.55523368
25Nitrogen metabolism_Homo sapiens_hsa009101.55242306
26Protein export_Homo sapiens_hsa030601.53352738
27Propanoate metabolism_Homo sapiens_hsa006401.52210996
28Ether lipid metabolism_Homo sapiens_hsa005651.46204150
29Type II diabetes mellitus_Homo sapiens_hsa049301.45528835
30Bile secretion_Homo sapiens_hsa049761.45514272
31Circadian rhythm_Homo sapiens_hsa047101.44854725
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.44530128
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.43450568
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.40313122
35Dopaminergic synapse_Homo sapiens_hsa047281.38028558
36Serotonergic synapse_Homo sapiens_hsa047261.35800297
37Vibrio cholerae infection_Homo sapiens_hsa051101.34922144
38Aldosterone synthesis and secretion_Homo sapiens_hsa049251.32885789
39Carbohydrate digestion and absorption_Homo sapiens_hsa049731.31389675
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.29737776
41Calcium signaling pathway_Homo sapiens_hsa040201.27962421
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.24981673
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.23245506
44Pentose and glucuronate interconversions_Homo sapiens_hsa000401.22942521
45Olfactory transduction_Homo sapiens_hsa047401.17251009
46Caffeine metabolism_Homo sapiens_hsa002321.15154759
47Salivary secretion_Homo sapiens_hsa049701.14912483
48Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14303052
49Mineral absorption_Homo sapiens_hsa049781.13722970
50Tryptophan metabolism_Homo sapiens_hsa003801.13134129
51cAMP signaling pathway_Homo sapiens_hsa040241.12644581
52Sphingolipid metabolism_Homo sapiens_hsa006001.11007184
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.09800506
54Oxytocin signaling pathway_Homo sapiens_hsa049211.08755387
55Vascular smooth muscle contraction_Homo sapiens_hsa042701.07588566
56Retinol metabolism_Homo sapiens_hsa008301.07106165
57Primary bile acid biosynthesis_Homo sapiens_hsa001201.06607105
58cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06432959
59Phototransduction_Homo sapiens_hsa047441.06244900
60Chemical carcinogenesis_Homo sapiens_hsa052041.05448089
61Oocyte meiosis_Homo sapiens_hsa041141.04885715
62Cocaine addiction_Homo sapiens_hsa050301.03416431
63Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.03063883
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.02490698
65alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.02282508
66Wnt signaling pathway_Homo sapiens_hsa043101.01440938
67Fatty acid degradation_Homo sapiens_hsa000711.00146932
68Linoleic acid metabolism_Homo sapiens_hsa005910.99739064
69Dorso-ventral axis formation_Homo sapiens_hsa043200.99711537
70Cardiac muscle contraction_Homo sapiens_hsa042600.99245061
71Gastric acid secretion_Homo sapiens_hsa049710.98348897
72Cyanoamino acid metabolism_Homo sapiens_hsa004600.98130763
73Cholinergic synapse_Homo sapiens_hsa047250.97866689
74Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.97573517
75Oxidative phosphorylation_Homo sapiens_hsa001900.95082618
76Long-term depression_Homo sapiens_hsa047300.94908414
77ABC transporters_Homo sapiens_hsa020100.92283288
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.92212311
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.92000890
80Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.91371570
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.91270008
82Fanconi anemia pathway_Homo sapiens_hsa034600.90045793
83beta-Alanine metabolism_Homo sapiens_hsa004100.88756378
84Inositol phosphate metabolism_Homo sapiens_hsa005620.88729680
85Peroxisome_Homo sapiens_hsa041460.88010727
86Axon guidance_Homo sapiens_hsa043600.87167027
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.86729234
88Huntingtons disease_Homo sapiens_hsa050160.85715565
89Renal cell carcinoma_Homo sapiens_hsa052110.83636711
90Estrogen signaling pathway_Homo sapiens_hsa049150.83273708
91Fatty acid metabolism_Homo sapiens_hsa012120.82795289
92ErbB signaling pathway_Homo sapiens_hsa040120.80652971
93Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80549095
94Glucagon signaling pathway_Homo sapiens_hsa049220.80280623
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.77718934
96Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.77029653
97mRNA surveillance pathway_Homo sapiens_hsa030150.74329067
98Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.74291658
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.73536854
100GnRH signaling pathway_Homo sapiens_hsa049120.73257326
101Arginine and proline metabolism_Homo sapiens_hsa003300.70615879
102Ovarian steroidogenesis_Homo sapiens_hsa049130.69500841
103Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66399305
104Arginine biosynthesis_Homo sapiens_hsa002200.66392156
105Ras signaling pathway_Homo sapiens_hsa040140.65576457
106Vitamin digestion and absorption_Homo sapiens_hsa049770.65275226
107Hedgehog signaling pathway_Homo sapiens_hsa043400.64680136
108Tight junction_Homo sapiens_hsa045300.64195527
109Starch and sucrose metabolism_Homo sapiens_hsa005000.63821421
110Fatty acid biosynthesis_Homo sapiens_hsa000610.63577961
111Pancreatic secretion_Homo sapiens_hsa049720.62682626
112Homologous recombination_Homo sapiens_hsa034400.61839724
113RNA transport_Homo sapiens_hsa030130.61828554
114Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61599791
115Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61361818
116Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61294383
117Alzheimers disease_Homo sapiens_hsa050100.60460445
118RNA polymerase_Homo sapiens_hsa030200.60330803
119Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59953435
120Glycerolipid metabolism_Homo sapiens_hsa005610.59745439
121Gap junction_Homo sapiens_hsa045400.59142969
122Glycosaminoglycan degradation_Homo sapiens_hsa005310.58402305
123Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.57703769
124Melanogenesis_Homo sapiens_hsa049160.57566049
125Fat digestion and absorption_Homo sapiens_hsa049750.57217333
126Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.56721952
127Sulfur metabolism_Homo sapiens_hsa009200.56272326
128Rheumatoid arthritis_Homo sapiens_hsa053230.55856790
129Regulation of autophagy_Homo sapiens_hsa041400.54894969
130Cell cycle_Homo sapiens_hsa041100.54855383
131mTOR signaling pathway_Homo sapiens_hsa041500.54019576
132MAPK signaling pathway_Homo sapiens_hsa040100.53800649
133Melanoma_Homo sapiens_hsa052180.53039398
134Renin-angiotensin system_Homo sapiens_hsa046140.51821947
135Dilated cardiomyopathy_Homo sapiens_hsa054140.50992917
136Glioma_Homo sapiens_hsa052140.50119925
137Sphingolipid signaling pathway_Homo sapiens_hsa040710.50111015
138Selenocompound metabolism_Homo sapiens_hsa004500.49089175
139PPAR signaling pathway_Homo sapiens_hsa033200.48686476
140Hippo signaling pathway_Homo sapiens_hsa043900.48164906
141RNA degradation_Homo sapiens_hsa030180.47253775
142Thyroid hormone synthesis_Homo sapiens_hsa049180.47160472
143Arachidonic acid metabolism_Homo sapiens_hsa005900.46384189
144Protein digestion and absorption_Homo sapiens_hsa049740.42724845
145Choline metabolism in cancer_Homo sapiens_hsa052310.42286024

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