NAPG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes soluble NSF attachment protein gamma. The soluble NSF attachment proteins (SNAPs) enable N-ethyl-maleimide-sensitive fusion protein (NSF) to bind to target membranes. NSF and SNAPs appear to be general components of the intracellular membrane fusion apparatus, and their action at specific sites of fusion must be controlled by SNAP receptors particular to the membranes being fused. The product of this gene mediates platelet exocytosis and controls the membrane fusion events of this process. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.61450752
2synaptic vesicle exocytosis (GO:0016079)5.52212981
3vocalization behavior (GO:0071625)5.37954120
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.21357546
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.03673338
6glutamate secretion (GO:0014047)4.99417046
7neuron cell-cell adhesion (GO:0007158)4.93528853
8regulation of synaptic vesicle exocytosis (GO:2000300)4.92285794
9regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.91753763
10protein localization to synapse (GO:0035418)4.88688427
11regulation of glutamate receptor signaling pathway (GO:1900449)4.83593270
12synaptic vesicle maturation (GO:0016188)4.83113711
13ionotropic glutamate receptor signaling pathway (GO:0035235)4.77630675
14neuronal action potential propagation (GO:0019227)4.77140122
15positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.74337657
16locomotory exploration behavior (GO:0035641)4.66037492
17synaptic vesicle docking involved in exocytosis (GO:0016081)4.42569211
18regulation of synaptic vesicle transport (GO:1902803)4.40889424
19glutamate receptor signaling pathway (GO:0007215)4.40374582
20neurotransmitter secretion (GO:0007269)4.33736800
21neuron-neuron synaptic transmission (GO:0007270)4.21757892
22synaptic transmission, glutamatergic (GO:0035249)4.16913194
23neurotransmitter-gated ion channel clustering (GO:0072578)4.14921851
24gamma-aminobutyric acid signaling pathway (GO:0007214)4.09846632
25negative regulation of synaptic transmission, GABAergic (GO:0032229)4.06946489
26exploration behavior (GO:0035640)4.02940258
27regulation of long-term neuronal synaptic plasticity (GO:0048169)3.94782347
28regulation of neuronal synaptic plasticity (GO:0048168)3.91851152
29presynaptic membrane assembly (GO:0097105)3.90986524
30gamma-aminobutyric acid transport (GO:0015812)3.88366124
31regulation of excitatory postsynaptic membrane potential (GO:0060079)3.78288774
32long-term memory (GO:0007616)3.68811506
33neurotransmitter transport (GO:0006836)3.67414856
34positive regulation of synapse maturation (GO:0090129)3.65907925
35long-term synaptic potentiation (GO:0060291)3.64270401
36postsynaptic membrane organization (GO:0001941)3.64058105
37presynaptic membrane organization (GO:0097090)3.62286186
38membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.60319986
39regulation of postsynaptic membrane potential (GO:0060078)3.60025792
40synaptic vesicle endocytosis (GO:0048488)3.56566974
41neuron recognition (GO:0008038)3.56280537
42proline transport (GO:0015824)3.55552000
43response to histamine (GO:0034776)3.55333178
44regulation of synapse structural plasticity (GO:0051823)3.49607639
45positive regulation of membrane potential (GO:0045838)3.46207321
46regulation of synaptic transmission, glutamatergic (GO:0051966)3.46031616
47regulation of neurotransmitter secretion (GO:0046928)3.44162152
48regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.44090709
49regulation of synaptic plasticity (GO:0048167)3.43569599
50protein K11-linked deubiquitination (GO:0035871)3.42233719
51G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.41192687
52transmission of nerve impulse (GO:0019226)3.40698982
53signal peptide processing (GO:0006465)3.36053326
54cellular potassium ion homeostasis (GO:0030007)3.35760774
55regulation of neurotransmitter levels (GO:0001505)3.34462981
56positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.33031231
57cerebellar Purkinje cell differentiation (GO:0021702)3.29863701
58regulation of vesicle fusion (GO:0031338)3.29524977
59detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.27708720
60negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.26702993
61layer formation in cerebral cortex (GO:0021819)3.24907068
62neuromuscular process controlling posture (GO:0050884)3.23387377
63activation of protein kinase A activity (GO:0034199)3.18630280
64regulation of neurotransmitter transport (GO:0051588)3.17558558
65neural tube formation (GO:0001841)3.15703922
66membrane depolarization (GO:0051899)3.15659904
67behavioral fear response (GO:0001662)3.15201032
68behavioral defense response (GO:0002209)3.15201032
69positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.12759313
70negative regulation of cytosolic calcium ion concentration (GO:0051481)3.11873878
71axonal fasciculation (GO:0007413)3.10703816
72cerebellar granule cell differentiation (GO:0021707)3.10567115
73protein localization to cilium (GO:0061512)3.10414322
74synaptic transmission (GO:0007268)3.09966348
75serotonin metabolic process (GO:0042428)3.08539331
76energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.08212114
77ATP hydrolysis coupled proton transport (GO:0015991)3.08212114
78positive regulation of neurotransmitter transport (GO:0051590)3.07915782
79positive regulation of synaptic transmission, GABAergic (GO:0032230)3.07604378
80indolalkylamine catabolic process (GO:0046218)3.07154098
81tryptophan catabolic process (GO:0006569)3.07154098
82indole-containing compound catabolic process (GO:0042436)3.07154098
83cellular ketone body metabolic process (GO:0046950)3.05823999
84establishment of protein localization to Golgi (GO:0072600)3.05524291
85indolalkylamine metabolic process (GO:0006586)3.05432081
86negative regulation of dendrite morphogenesis (GO:0050774)3.04137203
87fear response (GO:0042596)3.04066030
88kynurenine metabolic process (GO:0070189)3.04051983
89membrane depolarization during action potential (GO:0086010)3.03877728
90positive regulation of neurotransmitter secretion (GO:0001956)3.03473705
91response to pheromone (GO:0019236)3.02838598
92DNA double-strand break processing (GO:0000729)3.02684709
93regulation of glutamate secretion (GO:0014048)3.02295054
94learning (GO:0007612)3.02089953
95synapse assembly (GO:0007416)3.01970205
96regulation of dendritic spine morphogenesis (GO:0061001)3.01917853
97detection of calcium ion (GO:0005513)3.00974849
98regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.00379618
99positive regulation of synaptic transmission (GO:0050806)2.99660550
100regulation of synaptic transmission (GO:0050804)2.99238798
101startle response (GO:0001964)2.98573849
102dendritic spine morphogenesis (GO:0060997)2.98189750
103regulation of synapse maturation (GO:0090128)2.98072045
104behavioral response to cocaine (GO:0048148)2.98000767
105mating behavior (GO:0007617)2.97412989
106transferrin transport (GO:0033572)2.96933900
107auditory behavior (GO:0031223)2.94841151
108establishment of synaptic vesicle localization (GO:0097480)2.94210386
109synaptic vesicle transport (GO:0048489)2.94210386
110primary amino compound metabolic process (GO:1901160)2.93248039
111regulation of sarcomere organization (GO:0060297)2.92545933
112response to auditory stimulus (GO:0010996)2.91535575
113righting reflex (GO:0060013)2.89263607
114social behavior (GO:0035176)2.88726247
115intraspecies interaction between organisms (GO:0051703)2.88726247
116long term synaptic depression (GO:0060292)2.88623106
117G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.87163777
118regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.86661382
119ketone body metabolic process (GO:1902224)2.86493481
120vesicle transport along microtubule (GO:0047496)2.86425475
121reflex (GO:0060004)2.85559466
122indole-containing compound metabolic process (GO:0042430)2.77006945
123behavioral response to nicotine (GO:0035095)2.75945732
124fucose catabolic process (GO:0019317)2.71460529
125L-fucose metabolic process (GO:0042354)2.71460529
126L-fucose catabolic process (GO:0042355)2.71460529
127behavioral response to ethanol (GO:0048149)2.68580719
128detection of light stimulus involved in sensory perception (GO:0050962)2.67566285
129detection of light stimulus involved in visual perception (GO:0050908)2.67566285
130regulation of meiosis I (GO:0060631)2.65913083
131tryptophan metabolic process (GO:0006568)2.65742015
132positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.63346497
133regulation of glucokinase activity (GO:0033131)2.61912929
134regulation of hexokinase activity (GO:1903299)2.61912929
135L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.61525019
136prenylation (GO:0097354)2.61134213
137protein prenylation (GO:0018342)2.61134213
138platelet dense granule organization (GO:0060155)2.60731700
139inositol phosphate catabolic process (GO:0071545)2.59628021
140protein targeting to Golgi (GO:0000042)2.56810679
141adaptation of signaling pathway (GO:0023058)2.56411366
142neuronal action potential (GO:0019228)2.55764799
143polyol catabolic process (GO:0046174)2.55144886
144anterograde synaptic vesicle transport (GO:0048490)2.53681018
145monoubiquitinated protein deubiquitination (GO:0035520)2.50195616
146glycosphingolipid biosynthetic process (GO:0006688)2.50019560
147synapsis (GO:0007129)2.48956422
148water-soluble vitamin biosynthetic process (GO:0042364)2.48683349
149regulation of neurotransmitter uptake (GO:0051580)2.46560202
150piRNA metabolic process (GO:0034587)2.46487654
151methionine biosynthetic process (GO:0009086)2.45926193
152regulation of action potential (GO:0098900)2.45278607
153regulation of acyl-CoA biosynthetic process (GO:0050812)2.45117293
154regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.44537606
155detection of mechanical stimulus involved in sensory perception (GO:0050974)2.43130415
156positive regulation of meiosis (GO:0045836)2.42101831
157retinal cone cell development (GO:0046549)2.41894677
158tachykinin receptor signaling pathway (GO:0007217)2.41380270
159acrosome assembly (GO:0001675)2.39555179
160nucleobase catabolic process (GO:0046113)2.38234140
161auditory receptor cell stereocilium organization (GO:0060088)2.36940328
162glycerophospholipid catabolic process (GO:0046475)2.36863876
163respiratory chain complex IV assembly (GO:0008535)2.35748736
164replication fork processing (GO:0031297)2.33913936
165pyrimidine nucleobase catabolic process (GO:0006208)2.33214810
166cilium morphogenesis (GO:0060271)2.32853590
167inner ear receptor stereocilium organization (GO:0060122)2.32266608
168C4-dicarboxylate transport (GO:0015740)2.30517247
169oxidative demethylation (GO:0070989)2.30285987
170nonmotile primary cilium assembly (GO:0035058)2.29989408
171retrograde transport, vesicle recycling within Golgi (GO:0000301)2.29270025
172positive regulation of sodium ion transmembrane transport (GO:1902307)2.28344704
173action potential (GO:0001508)2.27033251
174positive regulation of meiotic cell cycle (GO:0051446)2.26428302

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.87635337
2GBX2_23144817_ChIP-Seq_PC3_Human4.19611432
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.15265671
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.04755399
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.98115480
6REST_21632747_ChIP-Seq_MESCs_Mouse2.66838267
7SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.65654222
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.57608317
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.57608317
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.56467882
11TAF15_26573619_Chip-Seq_HEK293_Human2.51858348
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.51207911
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.48028990
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.42655761
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.38982422
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.36956407
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.28187628
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.23274344
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.22930715
20RARB_27405468_Chip-Seq_BRAIN_Mouse2.20665903
21REST_18959480_ChIP-ChIP_MESCs_Mouse2.16055157
22EWS_26573619_Chip-Seq_HEK293_Human2.12783843
23DROSHA_22980978_ChIP-Seq_HELA_Human2.09853227
24CTBP2_25329375_ChIP-Seq_LNCAP_Human2.06963336
25SUZ12_27294783_Chip-Seq_ESCs_Mouse2.04921556
26EZH2_27294783_Chip-Seq_ESCs_Mouse2.02963677
27RNF2_27304074_Chip-Seq_ESCs_Mouse1.98680233
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.97286417
29IKZF1_21737484_ChIP-ChIP_HCT116_Human1.96408478
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.95379045
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.94121669
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.90301028
33SMAD4_21799915_ChIP-Seq_A2780_Human1.89627514
34FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.84552761
35AR_21572438_ChIP-Seq_LNCaP_Human1.81890555
36CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.81632982
37PCGF2_27294783_Chip-Seq_ESCs_Mouse1.78189530
38P300_19829295_ChIP-Seq_ESCs_Human1.77957822
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.74970464
40ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.73463779
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.66562553
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.65634664
43TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64679145
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.59243290
45BMI1_23680149_ChIP-Seq_NPCS_Mouse1.57311773
46VDR_22108803_ChIP-Seq_LS180_Human1.56037623
47* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.54226661
48* CBP_20019798_ChIP-Seq_JUKART_Human1.54226661
49SMAD_19615063_ChIP-ChIP_OVARY_Human1.51808547
50EZH2_27294783_Chip-Seq_NPCs_Mouse1.50575654
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.50004331
52MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.48997014
53NR3C1_23031785_ChIP-Seq_PC12_Mouse1.48801601
54BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.47995735
55SUZ12_27294783_Chip-Seq_NPCs_Mouse1.47588861
56* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.46145967
57AR_25329375_ChIP-Seq_VCAP_Human1.46006239
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43876411
59OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42816316
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.41987053
61FUS_26573619_Chip-Seq_HEK293_Human1.41396393
62IGF1R_20145208_ChIP-Seq_DFB_Human1.39976571
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37557027
64PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36463626
65ZNF274_21170338_ChIP-Seq_K562_Hela1.35550099
66CBX2_27304074_Chip-Seq_ESCs_Mouse1.35447521
67* SOX2_21211035_ChIP-Seq_LN229_Gbm1.35176740
68* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.33296069
69NFE2_27457419_Chip-Seq_LIVER_Mouse1.32798074
70TCF4_22108803_ChIP-Seq_LS180_Human1.31256390
71STAT3_23295773_ChIP-Seq_U87_Human1.29821896
72MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29368862
73KLF5_20875108_ChIP-Seq_MESCs_Mouse1.28259349
74RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25183361
75TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.25036074
76FLI1_21867929_ChIP-Seq_TH2_Mouse1.24700694
77RNF2_27304074_Chip-Seq_NSC_Mouse1.24545913
78POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.23648710
79NANOG_19829295_ChIP-Seq_ESCs_Human1.23544566
80SOX2_19829295_ChIP-Seq_ESCs_Human1.23544566
81CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23147558
82CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.23015378
83PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22095872
84RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.21445924
85* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21221639
86SMAD4_21741376_ChIP-Seq_EPCs_Human1.20997371
87AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20291496
88CRX_20693478_ChIP-Seq_RETINA_Mouse1.19921142
89ER_23166858_ChIP-Seq_MCF-7_Human1.19252683
90SUZ12_18555785_Chip-Seq_ESCs_Mouse1.19235863
91HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.18836092
92PRDM14_20953172_ChIP-Seq_ESCs_Human1.18312290
93* TCF4_23295773_ChIP-Seq_U87_Human1.17731280
94HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.17408406
95FOXM1_26456572_ChIP-Seq_MCF-7_Human1.16487655
96STAT3_18555785_Chip-Seq_ESCs_Mouse1.16266627
97ERG_21242973_ChIP-ChIP_JURKAT_Human1.15985132
98CDX2_22108803_ChIP-Seq_LS180_Human1.15485735
99RUNX2_22187159_ChIP-Seq_PCA_Human1.13413993
100ARNT_22903824_ChIP-Seq_MCF-7_Human1.12751038
101P300_18555785_Chip-Seq_ESCs_Mouse1.12476468
102RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12216550
103TP53_22573176_ChIP-Seq_HFKS_Human1.11674128
104ELK1_19687146_ChIP-ChIP_HELA_Human1.11294819
105* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11182293
106NANOG_18555785_Chip-Seq_ESCs_Mouse1.10061302
107AR_19668381_ChIP-Seq_PC3_Human1.09652526
108ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.09616886
109NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.09573784
110NRF2_20460467_ChIP-Seq_MEFs_Mouse1.09573784
111TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09144227
112SOX2_18555785_Chip-Seq_ESCs_Mouse1.09007475
113EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.08119004
114MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07668411
115RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.07335012
116* JUN_21703547_ChIP-Seq_K562_Human1.06055653
117RING1B_27294783_Chip-Seq_ESCs_Mouse1.05925731
118TAL1_26923725_Chip-Seq_HPCs_Mouse1.05816601
119TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.05184265
120P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04669958
121EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04413232
122EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04344887
123AHR_22903824_ChIP-Seq_MCF-7_Human1.03937190
124IRF1_19129219_ChIP-ChIP_H3396_Human1.03691979
125OCT4_21477851_ChIP-Seq_ESCs_Mouse1.03317353
126ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02620203
127NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01276657
128CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00615786
129CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.99987286
130YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98744728
131BCAT_22108803_ChIP-Seq_LS180_Human0.98727097
132TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98226411
133E2F1_18555785_Chip-Seq_ESCs_Mouse0.95451428
134* TP53_18474530_ChIP-ChIP_U2OS_Human0.93998829
135TP53_16413492_ChIP-PET_HCT116_Human0.93838751
136MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93053556
137EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.92080054
138CMYC_18555785_Chip-Seq_ESCs_Mouse0.90709287
139P53_22387025_ChIP-Seq_ESCs_Mouse0.90168520
140SMAD3_21741376_ChIP-Seq_ESCs_Human0.89834395
141WT1_25993318_ChIP-Seq_PODOCYTE_Human0.89016691
142MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.88367602
143KDM2B_26808549_Chip-Seq_REH_Human0.87840140
144TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87618749

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.78951014
2MP0003880_abnormal_central_pattern5.20969595
3MP0003635_abnormal_synaptic_transmissio4.05544445
4MP0009745_abnormal_behavioral_response3.56668944
5MP0004270_analgesia3.53982670
6MP0001968_abnormal_touch/_nociception3.38029498
7MP0009046_muscle_twitch3.33826166
8MP0002064_seizures3.32679551
9MP0002063_abnormal_learning/memory/cond3.25637292
10MP0002572_abnormal_emotion/affect_behav2.87838300
11MP0002736_abnormal_nociception_after2.85004297
12MP0002272_abnormal_nervous_system2.77753970
13MP0002735_abnormal_chemical_nociception2.75571741
14MP0002734_abnormal_mechanical_nocicepti2.69325127
15MP0001501_abnormal_sleep_pattern2.60177031
16MP0002822_catalepsy2.56429995
17MP0008877_abnormal_DNA_methylation2.52839783
18MP0001486_abnormal_startle_reflex2.45583254
19MP0003195_calcinosis2.45100629
20MP0001440_abnormal_grooming_behavior2.35679688
21MP0006276_abnormal_autonomic_nervous2.30323100
22MP0005423_abnormal_somatic_nervous2.28964159
23MP0002733_abnormal_thermal_nociception2.25732971
24MP0008057_abnormal_DNA_replication2.18058799
25MP0002067_abnormal_sensory_capabilities2.17531774
26MP0001970_abnormal_pain_threshold2.15792649
27MP0002102_abnormal_ear_morphology2.07529928
28MP0002184_abnormal_innervation1.81232264
29MP0005386_behavior/neurological_phenoty1.76150514
30MP0004924_abnormal_behavior1.76150514
31MP0002557_abnormal_social/conspecific_i1.73104629
32MP0005646_abnormal_pituitary_gland1.71492608
33MP0004147_increased_porphyrin_level1.70140089
34MP0008569_lethality_at_weaning1.69499864
35MP0009780_abnormal_chondrocyte_physiolo1.69399437
36MP0003329_amyloid_beta_deposits1.68624737
37MP0001984_abnormal_olfaction1.68056440
38MP0003787_abnormal_imprinting1.67910024
39MP0000778_abnormal_nervous_system1.65399538
40MP0000372_irregular_coat_pigmentation1.62000376
41MP0004811_abnormal_neuron_physiology1.59703251
42MP0001529_abnormal_vocalization1.57261803
43MP0001905_abnormal_dopamine_level1.56021011
44MP0000427_abnormal_hair_cycle1.52310691
45MP0004858_abnormal_nervous_system1.48214232
46MP0003879_abnormal_hair_cell1.47746135
47MP0001188_hyperpigmentation1.44834040
48MP0002909_abnormal_adrenal_gland1.43266892
49MP0002066_abnormal_motor_capabilities/c1.39259957
50MP0000955_abnormal_spinal_cord1.39103097
51MP0002882_abnormal_neuron_morphology1.37457097
52MP0003122_maternal_imprinting1.37328655
53MP0005645_abnormal_hypothalamus_physiol1.37181192
54MP0004142_abnormal_muscle_tone1.35367734
55MP0002837_dystrophic_cardiac_calcinosis1.33366456
56MP0005174_abnormal_tail_pigmentation1.32053929
57MP0003633_abnormal_nervous_system1.31154292
58MP0010386_abnormal_urinary_bladder1.25653924
59MP0005551_abnormal_eye_electrophysiolog1.20711804
60MP0001502_abnormal_circadian_rhythm1.17554965
61MP0003890_abnormal_embryonic-extraembry1.17436029
62MP0002928_abnormal_bile_duct1.15999060
63MP0002876_abnormal_thyroid_physiology1.13941797
64MP0003252_abnormal_bile_duct1.13054541
65MP0003631_nervous_system_phenotype1.12134896
66MP0005084_abnormal_gallbladder_morpholo1.10992286
67MP0002229_neurodegeneration1.08734663
68MP0004084_abnormal_cardiac_muscle1.04796477
69MP0008872_abnormal_physiological_respon1.01131014
70MP0009697_abnormal_copulation1.00512808
71MP0004885_abnormal_endolymph0.99836702
72MP0004145_abnormal_muscle_electrophysio0.98143832
73MP0000013_abnormal_adipose_tissue0.97813130
74MP0004742_abnormal_vestibular_system0.97591255
75MP0002160_abnormal_reproductive_system0.96239194
76MP0002152_abnormal_brain_morphology0.95636507
77MP0003121_genomic_imprinting0.95609995
78MP0000751_myopathy0.95428402
79MP0001963_abnormal_hearing_physiology0.93305384
80MP0003950_abnormal_plasma_membrane0.92683094
81MP0002069_abnormal_eating/drinking_beha0.91035419
82MP0000383_abnormal_hair_follicle0.89827651
83MP0008058_abnormal_DNA_repair0.89687811
84MP0002751_abnormal_autonomic_nervous0.89264869
85MP0008874_decreased_physiological_sensi0.88914771
86MP0005171_absent_coat_pigmentation0.88313261
87MP0003137_abnormal_impulse_conducting0.88178693
88MP0005535_abnormal_body_temperature0.87282711
89MP0005499_abnormal_olfactory_system0.87015826
90MP0005394_taste/olfaction_phenotype0.87015826
91MP0010678_abnormal_skin_adnexa0.86715809
92MP0002938_white_spotting0.86359202
93MP0003646_muscle_fatigue0.84502692
94MP0002090_abnormal_vision0.84184911
95MP0003183_abnormal_peptide_metabolism0.83624226
96MP0002638_abnormal_pupillary_reflex0.82690932
97MP0008775_abnormal_heart_ventricle0.82258593
98MP0000604_amyloidosis0.82160911
99MP0008995_early_reproductive_senescence0.81753261
100MP0008875_abnormal_xenobiotic_pharmacok0.81341036
101MP0006054_spinal_hemorrhage0.81073921
102MP0003718_maternal_effect0.80835245
103MP0000569_abnormal_digit_pigmentation0.80605678
104MP0003634_abnormal_glial_cell0.79864902
105MP0002752_abnormal_somatic_nervous0.78461511
106MP0004085_abnormal_heartbeat0.77620883
107MP0005187_abnormal_penis_morphology0.77432194
108MP0004133_heterotaxia0.76793387
109MP0000920_abnormal_myelination0.76561359
110MP0004215_abnormal_myocardial_fiber0.76376109
111MP0005410_abnormal_fertilization0.76271931
112MP0006035_abnormal_mitochondrial_morpho0.75787292
113MP0003698_abnormal_male_reproductive0.75746921
114MP0003632_abnormal_nervous_system0.74123146
115MP0003690_abnormal_glial_cell0.73918855
116MP0000647_abnormal_sebaceous_gland0.73501236
117MP0001177_atelectasis0.71936484
118MP0004484_altered_response_of0.71652844
119MP0001664_abnormal_digestion0.71178293
120MP0006072_abnormal_retinal_apoptosis0.69398333
121MP0004510_myositis0.64855074
122MP0000631_abnormal_neuroendocrine_gland0.64233014
123MP0004043_abnormal_pH_regulation0.62969449
124MP0001986_abnormal_taste_sensitivity0.62049133
125MP0005409_darkened_coat_color0.61433376
126MP0000026_abnormal_inner_ear0.53708448
127MP0005253_abnormal_eye_physiology0.52981042
128MP0005379_endocrine/exocrine_gland_phen0.52960143
129MP0001943_abnormal_respiration0.51471867
130MP0003075_altered_response_to0.50725143
131MP0001485_abnormal_pinna_reflex0.50692227
132MP0003172_abnormal_lysosome_physiology0.48230363
133MP0003956_abnormal_body_size0.47849665
134MP0010770_preweaning_lethality0.45761411
135MP0002082_postnatal_lethality0.45761411

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.32871349
2Myokymia (HP:0002411)6.17237288
3Focal seizures (HP:0007359)5.82970646
4Atonic seizures (HP:0010819)5.71961870
5Epileptic encephalopathy (HP:0200134)5.41104541
6Visual hallucinations (HP:0002367)5.22768548
7Febrile seizures (HP:0002373)5.18082180
8Absence seizures (HP:0002121)4.72986882
9Dialeptic seizures (HP:0011146)4.45784954
10Hyperventilation (HP:0002883)4.32730393
11Progressive cerebellar ataxia (HP:0002073)4.22551563
12Generalized tonic-clonic seizures (HP:0002069)4.10619218
13Pancreatic cysts (HP:0001737)3.74312449
14Broad-based gait (HP:0002136)3.54247742
15Action tremor (HP:0002345)3.51469736
16Supranuclear gaze palsy (HP:0000605)3.37725441
17Gaze-evoked nystagmus (HP:0000640)3.30254030
18Abnormality of the renal cortex (HP:0011035)3.26818827
19Pancreatic fibrosis (HP:0100732)3.24211996
20Truncal ataxia (HP:0002078)3.15829414
21Amblyopia (HP:0000646)3.13098879
22Renal cortical cysts (HP:0000803)3.09925137
23True hermaphroditism (HP:0010459)3.06048044
24Progressive inability to walk (HP:0002505)3.00136302
25Impaired vibration sensation in the lower limbs (HP:0002166)2.98495184
26Dysdiadochokinesis (HP:0002075)2.94091979
27Pheochromocytoma (HP:0002666)2.93646683
28Poor eye contact (HP:0000817)2.90235484
29Depression (HP:0000716)2.90209392
30Dysmetria (HP:0001310)2.86984491
31Anxiety (HP:0000739)2.85662182
32Abnormal eating behavior (HP:0100738)2.83493412
33Drooling (HP:0002307)2.82792052
34Excessive salivation (HP:0003781)2.82792052
35Ankle clonus (HP:0011448)2.77350132
36Hemiparesis (HP:0001269)2.77185413
37Molar tooth sign on MRI (HP:0002419)2.71897602
38Abnormality of midbrain morphology (HP:0002418)2.71897602
39Congenital stationary night blindness (HP:0007642)2.71752593
40Abnormality of binocular vision (HP:0011514)2.69726169
41Diplopia (HP:0000651)2.69726169
42Scanning speech (HP:0002168)2.69645911
43Abnormal social behavior (HP:0012433)2.68885545
44Impaired social interactions (HP:0000735)2.68885545
45Nephronophthisis (HP:0000090)2.67336972
46Fair hair (HP:0002286)2.66551686
47Gait imbalance (HP:0002141)2.62746346
48Abnormality of the renal medulla (HP:0100957)2.57868250
49Neuroendocrine neoplasm (HP:0100634)2.57476016
50Urinary bladder sphincter dysfunction (HP:0002839)2.56927007
51Insidious onset (HP:0003587)2.56266905
52Termporal pattern (HP:0011008)2.56266905
53Epileptiform EEG discharges (HP:0011182)2.53331951
54Inability to walk (HP:0002540)2.50411112
55Absent speech (HP:0001344)2.49058553
56Abnormality of the corticospinal tract (HP:0002492)2.46507405
57Cerebral inclusion bodies (HP:0100314)2.46455613
58Mutism (HP:0002300)2.44124160
59Limb dystonia (HP:0002451)2.43619678
60Abnormal hair whorl (HP:0010721)2.41738756
61Impaired smooth pursuit (HP:0007772)2.39620021
62Neurofibrillary tangles (HP:0002185)2.38114960
63Polyphagia (HP:0002591)2.34458868
64EEG with generalized epileptiform discharges (HP:0011198)2.33267420
65Congenital primary aphakia (HP:0007707)2.32219451
66Fetal akinesia sequence (HP:0001989)2.31369161
67Methylmalonic acidemia (HP:0002912)2.28584930
68Postural instability (HP:0002172)2.28404134
69Urinary urgency (HP:0000012)2.26953661
70Medial flaring of the eyebrow (HP:0010747)2.26435177
71Ketoacidosis (HP:0001993)2.25831061
72Protruding tongue (HP:0010808)2.25001953
73Blue irides (HP:0000635)2.24773041
74Bradykinesia (HP:0002067)2.23973971
75Generalized hypopigmentation of hair (HP:0011358)2.23393678
76Large for gestational age (HP:0001520)2.20996192
77Type II lissencephaly (HP:0007260)2.19522884
78Status epilepticus (HP:0002133)2.18838350
79Spastic gait (HP:0002064)2.16805190
80Nephrogenic diabetes insipidus (HP:0009806)2.15854386
81Abnormality of ocular smooth pursuit (HP:0000617)2.15787068
82Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.12710370
83Abnormality of alanine metabolism (HP:0010916)2.12710370
84Hyperalaninemia (HP:0003348)2.12710370
85Hypsarrhythmia (HP:0002521)2.12204658
86Abnormal drinking behavior (HP:0030082)2.11749370
87Polydipsia (HP:0001959)2.11749370
88Tubulointerstitial nephritis (HP:0001970)2.11115392
89Generalized myoclonic seizures (HP:0002123)2.10946244
90Aplasia/Hypoplasia of the tibia (HP:0005772)2.10426433
91Impaired vibratory sensation (HP:0002495)2.09040717
92Furrowed tongue (HP:0000221)2.08209073
93Specific learning disability (HP:0001328)2.07213563
94Genetic anticipation (HP:0003743)2.06757407
95Failure to thrive in infancy (HP:0001531)2.06233576
96Aplasia/Hypoplasia of the tongue (HP:0010295)2.05669690
97Delusions (HP:0000746)2.04574662
98Hemiplegia (HP:0002301)2.03043324
99Chronic hepatic failure (HP:0100626)2.02419411
100Acute necrotizing encephalopathy (HP:0006965)2.02124333
101Degeneration of the lateral corticospinal tracts (HP:0002314)2.01953501
102Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.01953501
103Stereotypic behavior (HP:0000733)2.01873341
104Cystic liver disease (HP:0006706)1.99712306
105Lissencephaly (HP:0001339)1.99669502
106Widely spaced teeth (HP:0000687)1.99365881
107Abnormality of salivation (HP:0100755)1.98331057
108Poor coordination (HP:0002370)1.97818582
109Gait ataxia (HP:0002066)1.96986013
110Abnormality of the lower motor neuron (HP:0002366)1.96889774
111Resting tremor (HP:0002322)1.94195693
112Lower limb muscle weakness (HP:0007340)1.93589297
113Attenuation of retinal blood vessels (HP:0007843)1.93251565
114Incomplete penetrance (HP:0003829)1.93077280
115Psychosis (HP:0000709)1.92575286
116Intestinal atresia (HP:0011100)1.92501103
117Dysmetric saccades (HP:0000641)1.92079398
118Progressive macrocephaly (HP:0004481)1.91667502
119Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.91055088
120Genital tract atresia (HP:0001827)1.90223346
121Abnormal mitochondria in muscle tissue (HP:0008316)1.89644915
122Abnormality of vitamin B metabolism (HP:0004340)1.89226522
123Intention tremor (HP:0002080)1.87464551
124Agitation (HP:0000713)1.86998107
125Vaginal atresia (HP:0000148)1.86588090
126Papilledema (HP:0001085)1.86022326
127Torticollis (HP:0000473)1.85167033
128Esotropia (HP:0000565)1.85042411
129Poor suck (HP:0002033)1.83799395
130Hypothermia (HP:0002045)1.81563687
131Focal dystonia (HP:0004373)1.81381080
132Metaphyseal dysplasia (HP:0100255)1.78160217
133Abnormality of the labia minora (HP:0012880)1.77730485
134Decreased central vision (HP:0007663)1.77361543
135Methylmalonic aciduria (HP:0012120)1.76902641
136Thickened helices (HP:0000391)1.75210014
137Hypoventilation (HP:0002791)1.74057074
138Abolished electroretinogram (ERG) (HP:0000550)1.73918060
139Acute encephalopathy (HP:0006846)1.73443011
140Horizontal nystagmus (HP:0000666)1.72268459
141Sclerocornea (HP:0000647)1.71677560
142Abnormality of the vitamin B12 metabolism (HP:0004341)1.71491979
143Increased CSF lactate (HP:0002490)1.71113966
144Papillary thyroid carcinoma (HP:0002895)1.69964165
145Tubular atrophy (HP:0000092)1.69889728
146Small hand (HP:0200055)1.66692767
147Hypomagnesemia (HP:0002917)1.65125468
148Postaxial foot polydactyly (HP:0001830)1.62925702
149Ketosis (HP:0001946)1.62573480
150Thyroid carcinoma (HP:0002890)1.62168510
151Polyuria (HP:0000103)1.61831902
152Pachygyria (HP:0001302)1.61470304
153Muscular hypotonia of the trunk (HP:0008936)1.60306867
154Abnormality of the astrocytes (HP:0100707)1.56784424
155Astrocytoma (HP:0009592)1.56784424
156Glioma (HP:0009733)1.55854241
157Postaxial hand polydactyly (HP:0001162)1.55799988
158Astigmatism (HP:0000483)1.55650809
159Central scotoma (HP:0000603)1.54434008
160Decreased circulating renin level (HP:0003351)1.54336809

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.46736256
2NTRK34.54368706
3CASK4.01342743
4EPHA43.83497964
5MAP3K43.22615838
6MAP3K123.19137413
7MAP3K93.13876388
8MAP2K73.04701572
9RIPK42.62300532
10MINK12.55757892
11TRIM282.34942839
12MARK12.33261810
13BMPR1B2.23564497
14MAP4K22.20036858
15DAPK22.12551955
16ACVR1B2.10539562
17MAP2K42.09282195
18PLK21.97020531
19ERBB31.93188610
20TNIK1.92926136
21MKNK21.92781493
22GRK51.92155094
23ARAF1.80675074
24NUAK11.76095889
25KSR21.73405699
26PAK61.66906951
27MST41.65672785
28PNCK1.64576693
29DAPK11.61257244
30NTRK21.60781851
31CDK191.57735086
32NTRK11.56196131
33STK391.49380492
34ZAK1.46679665
35GRK11.46567675
36EIF2AK31.45651008
37CDK51.40204440
38MAPK131.35228834
39CAMKK21.32016574
40KSR11.30875924
41CAMKK11.29825990
42PRKCG1.28313127
43PRPF4B1.26480641
44NME11.24465739
45MAP3K131.24190401
46FES1.20040754
47AKT31.14772819
48INSRR1.14455622
49CAMK2A1.13826412
50BMPR21.12741222
51OXSR11.11194607
52BRSK21.10958226
53FGFR21.03893385
54STK38L1.03251303
55CAMK2B1.02548796
56PTK2B1.02475814
57SGK2231.00599055
58SGK4941.00599055
59PRKD30.99633355
60PIK3CA0.98684353
61PLK30.96138047
62MAP3K20.94978819
63SGK20.94097610
64CCNB10.91467171
65STK380.90584620
66WNK40.90485304
67MKNK10.84414349
68UHMK10.84254472
69TAOK30.81015130
70STK30.79375921
71SIK20.79373688
72CSNK1G10.78848029
73CDK180.78678854
74RAF10.78247766
75PRKCE0.75340197
76TNK20.75273279
77GRK70.75169383
78CDK140.75007011
79PHKG20.74742092
80PHKG10.74742092
81CDK150.73502270
82DYRK1A0.69782058
83WEE10.69740239
84FGR0.69279791
85CAMK10.66595023
86SGK10.65453999
87VRK10.64699296
88CDK11A0.62236340
89LATS20.61692699
90PLK40.61626432
91STK110.60143651
92SIK30.59847594
93PRKCH0.59134998
94CAMK2D0.58512259
95FER0.57581260
96PAK30.57454610
97SGK30.57244946
98ADRBK20.56984529
99EIF2AK10.56774401
100MAP3K10.56708743
101RET0.56589008
102PIK3CG0.56341207
103CSNK1A1L0.55673564
104BCR0.55371000
105IRAK10.55134800
106CSNK1G30.54572794
107IRAK20.54259318
108TRPM70.53359624
109BRAF0.53273616
110CAMK2G0.52974812
111CSNK1G20.52955487
112ADRBK10.52525470
113MAP2K10.51876530
114NLK0.50321810
115TYRO30.49481519
116WNK30.48453336
117MUSK0.46035643
118PKN10.45124480
119PINK10.43979962
120RPS6KA20.43234679
121DYRK20.42846786
122PDK10.41729049
123YES10.41545418
124CDK30.41508085
125PDPK10.41266810
126TSSK60.39520390
127RPS6KA30.39337398
128SRPK10.37806705
129NEK60.37298969
130TLK10.36995263
131TEC0.36234058
132ROCK20.36085238
133MAPKAPK50.35703505
134MAPK120.35602851
135PRKACA0.35548467
136FYN0.35205855
137PRKG10.34907131
138PRKCZ0.34554676
139LMTK20.34478279
140MAPK100.33231299
141TAOK10.32859518
142EIF2AK20.32656618
143CSNK1D0.32522326
144PRKAA10.31929611
145PRKCB0.31194800
146DAPK30.30987165

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.06924925
2Synaptic vesicle cycle_Homo sapiens_hsa047213.65597177
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.87970894
4GABAergic synapse_Homo sapiens_hsa047272.77463515
5Olfactory transduction_Homo sapiens_hsa047402.66063736
6Circadian entrainment_Homo sapiens_hsa047132.64849256
7Long-term potentiation_Homo sapiens_hsa047202.63906275
8Collecting duct acid secretion_Homo sapiens_hsa049662.56282892
9Morphine addiction_Homo sapiens_hsa050322.55922270
10Glutamatergic synapse_Homo sapiens_hsa047242.50880371
11Butanoate metabolism_Homo sapiens_hsa006502.46461417
12Amphetamine addiction_Homo sapiens_hsa050312.44769650
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.38915240
14Protein export_Homo sapiens_hsa030602.36728880
15Dopaminergic synapse_Homo sapiens_hsa047282.14121668
16Salivary secretion_Homo sapiens_hsa049702.12899236
17Taste transduction_Homo sapiens_hsa047422.00963708
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.96618779
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.90032277
20Insulin secretion_Homo sapiens_hsa049111.89630544
21Serotonergic synapse_Homo sapiens_hsa047261.84376458
22Renin secretion_Homo sapiens_hsa049241.79510255
23Cholinergic synapse_Homo sapiens_hsa047251.78462485
24Long-term depression_Homo sapiens_hsa047301.75641067
25Gastric acid secretion_Homo sapiens_hsa049711.74564992
26Propanoate metabolism_Homo sapiens_hsa006401.70682033
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.63134481
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.61572249
29Calcium signaling pathway_Homo sapiens_hsa040201.58546921
30Basal transcription factors_Homo sapiens_hsa030221.58123903
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.57698172
32Oxytocin signaling pathway_Homo sapiens_hsa049211.54589643
33Vibrio cholerae infection_Homo sapiens_hsa051101.52816273
34Ether lipid metabolism_Homo sapiens_hsa005651.52353696
35Nitrogen metabolism_Homo sapiens_hsa009101.52122406
36Cocaine addiction_Homo sapiens_hsa050301.51712770
37Tryptophan metabolism_Homo sapiens_hsa003801.50205693
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.49049460
39Oxidative phosphorylation_Homo sapiens_hsa001901.48695537
40Phototransduction_Homo sapiens_hsa047441.40769890
41Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.40322650
42Linoleic acid metabolism_Homo sapiens_hsa005911.38682366
43Selenocompound metabolism_Homo sapiens_hsa004501.35387936
44Primary bile acid biosynthesis_Homo sapiens_hsa001201.33585048
45GnRH signaling pathway_Homo sapiens_hsa049121.32419030
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.31917442
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.30525006
48Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.29907024
49Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.21126618
50Gap junction_Homo sapiens_hsa045401.18479988
51Alzheimers disease_Homo sapiens_hsa050101.17957634
52Cardiac muscle contraction_Homo sapiens_hsa042601.17429700
53alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.17124479
54cAMP signaling pathway_Homo sapiens_hsa040241.16606925
55Steroid hormone biosynthesis_Homo sapiens_hsa001401.12819663
56Fanconi anemia pathway_Homo sapiens_hsa034601.12658265
57Phosphatidylinositol signaling system_Homo sapiens_hsa040701.09859167
58ABC transporters_Homo sapiens_hsa020101.09183594
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.08840228
60Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.07051233
61Parkinsons disease_Homo sapiens_hsa050121.03491073
62Estrogen signaling pathway_Homo sapiens_hsa049151.03303287
63Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02202869
64Non-homologous end-joining_Homo sapiens_hsa034501.01000419
65Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.98044810
66Caffeine metabolism_Homo sapiens_hsa002320.97593061
67Regulation of autophagy_Homo sapiens_hsa041400.97412055
68Homologous recombination_Homo sapiens_hsa034400.97156655
69cGMP-PKG signaling pathway_Homo sapiens_hsa040220.92549577
70Type II diabetes mellitus_Homo sapiens_hsa049300.91193647
71Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.91058647
72Vascular smooth muscle contraction_Homo sapiens_hsa042700.89962738
73Melanogenesis_Homo sapiens_hsa049160.89879495
74Glioma_Homo sapiens_hsa052140.88528638
75beta-Alanine metabolism_Homo sapiens_hsa004100.86803562
76Axon guidance_Homo sapiens_hsa043600.86664077
77RNA polymerase_Homo sapiens_hsa030200.85695208
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.82761179
79RNA degradation_Homo sapiens_hsa030180.82676948
80Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.82406055
81ErbB signaling pathway_Homo sapiens_hsa040120.82172812
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.79598239
83Pancreatic secretion_Homo sapiens_hsa049720.77004863
84Rheumatoid arthritis_Homo sapiens_hsa053230.75615030
85Vitamin B6 metabolism_Homo sapiens_hsa007500.74927066
86Type I diabetes mellitus_Homo sapiens_hsa049400.72819268
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70718772
88Thyroid hormone synthesis_Homo sapiens_hsa049180.69543823
89Steroid biosynthesis_Homo sapiens_hsa001000.69112913
90Oocyte meiosis_Homo sapiens_hsa041140.68418822
91Huntingtons disease_Homo sapiens_hsa050160.68412709
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68371221
93Peroxisome_Homo sapiens_hsa041460.68180561
94Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66366897
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65704367
96Retinol metabolism_Homo sapiens_hsa008300.64675441
97Dorso-ventral axis formation_Homo sapiens_hsa043200.64018519
98Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.61562312
99Sphingolipid metabolism_Homo sapiens_hsa006000.61475758
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.61270708
101MAPK signaling pathway_Homo sapiens_hsa040100.60855723
102Glucagon signaling pathway_Homo sapiens_hsa049220.55539916
103Choline metabolism in cancer_Homo sapiens_hsa052310.54706184
104Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53030839
105Fatty acid elongation_Homo sapiens_hsa000620.52014972
106Dilated cardiomyopathy_Homo sapiens_hsa054140.51828712
107Ras signaling pathway_Homo sapiens_hsa040140.51809700
108Phagosome_Homo sapiens_hsa041450.51188337
109Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50091127
110Chemical carcinogenesis_Homo sapiens_hsa052040.50006435
111Glycerolipid metabolism_Homo sapiens_hsa005610.49499277
112Inositol phosphate metabolism_Homo sapiens_hsa005620.49312942
113Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.48623231
114Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48266988
115Fatty acid metabolism_Homo sapiens_hsa012120.47404573
116Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47219555
117Mineral absorption_Homo sapiens_hsa049780.46360308
118Histidine metabolism_Homo sapiens_hsa003400.46256215
119Purine metabolism_Homo sapiens_hsa002300.46201743
120African trypanosomiasis_Homo sapiens_hsa051430.43589843
121One carbon pool by folate_Homo sapiens_hsa006700.42978256
122Neurotrophin signaling pathway_Homo sapiens_hsa047220.42330634
123Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42287935
124Metabolic pathways_Homo sapiens_hsa011000.41873365
125Alcoholism_Homo sapiens_hsa050340.41569746
126Sphingolipid signaling pathway_Homo sapiens_hsa040710.39733395
127Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.39689809
128VEGF signaling pathway_Homo sapiens_hsa043700.38872359
129Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.38555201
130Circadian rhythm_Homo sapiens_hsa047100.37498698
131Rap1 signaling pathway_Homo sapiens_hsa040150.37280165
132Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31702367
133Endocytosis_Homo sapiens_hsa041440.28555825
134Chemokine signaling pathway_Homo sapiens_hsa040620.27631507
135Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.27477424
136Prion diseases_Homo sapiens_hsa050200.27331540
137Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26987658
138Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.26650218
139Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.26047749
140Thyroid hormone signaling pathway_Homo sapiens_hsa049190.25648461
141Ovarian steroidogenesis_Homo sapiens_hsa049130.25385219
142Insulin signaling pathway_Homo sapiens_hsa049100.24482744
143Bile secretion_Homo sapiens_hsa049760.22538556
144Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.22468246
145Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.22256635
146Renal cell carcinoma_Homo sapiens_hsa052110.20857269
147Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.20659838
148Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.20009495
149Glycerophospholipid metabolism_Homo sapiens_hsa005640.18838610

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