NAPRT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Nicotinic acid (NA; niacin) is converted by nicotinic acid phosphoribosyltransferase (NAPRT; EC 2.4.2.11) to NA mononucleotide (NaMN), which is then converted to NA adenine dinucleotide (NaAD), and finally to nicotinamide adenine dinucleotide (NAD), which serves as a coenzyme in cellular redox reactions and is an essential component of a variety of processes in cellular metabolism including response to stress (Hara et al., 2007). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.94759060
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.94759060
3L-phenylalanine metabolic process (GO:0006558)6.87679794
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.87679794
5triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.30931163
6aromatic amino acid family catabolic process (GO:0009074)6.25898867
7sulfur amino acid catabolic process (GO:0000098)6.17336008
8glyoxylate metabolic process (GO:0046487)5.72304271
9tryptophan catabolic process (GO:0006569)5.70380162
10indole-containing compound catabolic process (GO:0042436)5.70380162
11indolalkylamine catabolic process (GO:0046218)5.70380162
12kynurenine metabolic process (GO:0070189)5.60311148
13bile acid biosynthetic process (GO:0006699)5.41656968
14high-density lipoprotein particle remodeling (GO:0034375)5.39367227
15cysteine metabolic process (GO:0006534)5.32694721
16tryptophan metabolic process (GO:0006568)5.32019648
17urea cycle (GO:0000050)5.26252463
18urea metabolic process (GO:0019627)5.26252463
19alpha-linolenic acid metabolic process (GO:0036109)5.23337965
20serine family amino acid catabolic process (GO:0009071)5.07972714
21negative regulation of fibrinolysis (GO:0051918)5.01562898
22regulation of cholesterol esterification (GO:0010872)4.93978227
23nitrogen cycle metabolic process (GO:0071941)4.87517920
24bile acid metabolic process (GO:0008206)4.86021660
25reverse cholesterol transport (GO:0043691)4.84499557
26peptidyl-glutamic acid carboxylation (GO:0017187)4.82319769
27protein carboxylation (GO:0018214)4.82319769
28regulation of fibrinolysis (GO:0051917)4.80954367
29regulation of triglyceride catabolic process (GO:0010896)4.77204272
30regulation of protein activation cascade (GO:2000257)4.74852385
31acylglycerol homeostasis (GO:0055090)4.71797706
32triglyceride homeostasis (GO:0070328)4.71797706
33fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.68386682
34phospholipid efflux (GO:0033700)4.67422892
35complement activation, alternative pathway (GO:0006957)4.65723309
36homocysteine metabolic process (GO:0050667)4.64143907
37plasma lipoprotein particle remodeling (GO:0034369)4.63003875
38protein-lipid complex remodeling (GO:0034368)4.63003875
39macromolecular complex remodeling (GO:0034367)4.63003875
40negative regulation of cholesterol transport (GO:0032375)4.62110589
41negative regulation of sterol transport (GO:0032372)4.62110589
42aromatic amino acid family metabolic process (GO:0009072)4.57321870
43amino-acid betaine metabolic process (GO:0006577)4.55671606
44lysine metabolic process (GO:0006553)4.46036681
45lysine catabolic process (GO:0006554)4.46036681
46alpha-amino acid catabolic process (GO:1901606)4.43113975
47regulation of complement activation (GO:0030449)4.42111897
48bile acid and bile salt transport (GO:0015721)4.37977118
49plasma lipoprotein particle assembly (GO:0034377)4.35685616
50cellular ketone body metabolic process (GO:0046950)4.35227409
51very-low-density lipoprotein particle assembly (GO:0034379)4.33981524
52cholesterol efflux (GO:0033344)4.32738435
53glycine metabolic process (GO:0006544)4.23178789
54cellular glucuronidation (GO:0052695)4.22249900
55tyrosine metabolic process (GO:0006570)4.20822640
56cellular amino acid catabolic process (GO:0009063)4.19994637
57response to peptidoglycan (GO:0032494)4.17767845
58intestinal cholesterol absorption (GO:0030299)4.17467089
59plasma lipoprotein particle clearance (GO:0034381)4.15608568
60serine family amino acid metabolic process (GO:0009069)4.12608136
61regulation of cholesterol homeostasis (GO:2000188)4.12529024
62antigen processing and presentation of endogenous antigen (GO:0019883)4.07966771
63imidazole-containing compound metabolic process (GO:0052803)4.03802294
64ethanol oxidation (GO:0006069)4.03727920
65negative regulation of erythrocyte differentiation (GO:0045647)4.03696457
66GDP-mannose metabolic process (GO:0019673)4.00829498
67detection of bacterium (GO:0016045)3.99979293
68negative regulation of fatty acid biosynthetic process (GO:0045717)3.99110996
69glutamate metabolic process (GO:0006536)3.99104366
70cellular modified amino acid catabolic process (GO:0042219)3.98515519
71drug catabolic process (GO:0042737)3.98023626
72indolalkylamine metabolic process (GO:0006586)3.93953593
73amine catabolic process (GO:0009310)3.93699860
74cellular biogenic amine catabolic process (GO:0042402)3.93699860
75serine family amino acid biosynthetic process (GO:0009070)3.93496296
76coenzyme catabolic process (GO:0009109)3.92029805
77low-density lipoprotein particle remodeling (GO:0034374)3.89510797
78positive regulation of triglyceride lipase activity (GO:0061365)3.88159337
79positive regulation of lipoprotein lipase activity (GO:0051006)3.88159337
80cholesterol homeostasis (GO:0042632)3.86703492
81regulation of bile acid biosynthetic process (GO:0070857)3.86272052
82protein-lipid complex assembly (GO:0065005)3.86155408
83benzene-containing compound metabolic process (GO:0042537)3.85801185
84detection of other organism (GO:0098543)3.82627257
85flavonoid metabolic process (GO:0009812)3.81238882
86heme transport (GO:0015886)3.79825217
87sterol homeostasis (GO:0055092)3.79611222
88arginine metabolic process (GO:0006525)3.77615903
89proline metabolic process (GO:0006560)3.77305103
90immunoglobulin mediated immune response (GO:0016064)3.74617870
91ketone body metabolic process (GO:1902224)3.74139937
92organic acid catabolic process (GO:0016054)3.72845274
93carboxylic acid catabolic process (GO:0046395)3.72845274
94plasma lipoprotein particle organization (GO:0071827)3.72806194
95uronic acid metabolic process (GO:0006063)3.72483233
96glucuronate metabolic process (GO:0019585)3.72483233
97glutamine family amino acid biosynthetic process (GO:0009084)3.72065843
98acetyl-CoA metabolic process (GO:0006084)3.69984266
99short-chain fatty acid metabolic process (GO:0046459)3.68040728
100antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.66886120
101phospholipid homeostasis (GO:0055091)3.63277917
102cytolysis (GO:0019835)3.58737411
103fatty acid beta-oxidation (GO:0006635)3.58283170
104fibrinolysis (GO:0042730)3.58219152
105lipoprotein metabolic process (GO:0042157)3.58167850
106dicarboxylic acid biosynthetic process (GO:0043650)3.57503483
107response to nitrosative stress (GO:0051409)3.57008506
108positive regulation of lipid catabolic process (GO:0050996)3.56746003
109neutrophil activation involved in immune response (GO:0002283)3.47467058
110antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.44503607
111positive regulation of gamma-delta T cell activation (GO:0046645)3.30913749
112modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.22457934
113positive regulation by organism of defense response of other organism involved in symbiotic interact3.22457934
114modulation by symbiont of host immune response (GO:0052553)3.22457934
115positive regulation by symbiont of host defense response (GO:0052509)3.22457934
116modulation by symbiont of host defense response (GO:0052031)3.22457934
117modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.22457934
118positive regulation of Cdc42 GTPase activity (GO:0043089)3.21587416
119mannose metabolic process (GO:0006013)3.21496969
120angiotensin maturation (GO:0002003)3.08875539
121NADH metabolic process (GO:0006734)3.08516480
122antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.02990112
123regulation of dendritic cell antigen processing and presentation (GO:0002604)2.93000543
124detection of external biotic stimulus (GO:0098581)2.91222920
125positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.84865060
126pinocytosis (GO:0006907)2.83034063
127Arp2/3 complex-mediated actin nucleation (GO:0034314)2.80665950
128deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.78389738
129response to muramyl dipeptide (GO:0032495)2.77208760
130positive thymic T cell selection (GO:0045059)2.76283340
131regulation of mast cell degranulation (GO:0043304)2.76264672
132positive regulation of antigen processing and presentation (GO:0002579)2.74668070
133regulation of interferon-beta biosynthetic process (GO:0045357)2.73903751
134glycosphingolipid catabolic process (GO:0046479)2.73302995
135negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.70905504
136negative regulation of cell killing (GO:0031342)2.70905504
137regulation of myeloid leukocyte mediated immunity (GO:0002886)2.70572816
138macrophage activation involved in immune response (GO:0002281)2.69171615
139regulation of leukocyte degranulation (GO:0043300)2.67504368
140positive regulation of B cell differentiation (GO:0045579)2.67250546
141B cell mediated immunity (GO:0019724)2.65734720
142regulation of cellular extravasation (GO:0002691)2.64084624
143NIK/NF-kappaB signaling (GO:0038061)2.64064189
144detection of biotic stimulus (GO:0009595)2.60736817
145positive regulation of fatty acid biosynthetic process (GO:0045723)2.59590641
146pentose-phosphate shunt (GO:0006098)2.58831672
147chaperone mediated protein folding requiring cofactor (GO:0051085)2.57787946
148regulation of necrotic cell death (GO:0010939)2.57380122
149pentose metabolic process (GO:0019321)2.57035527
150mature B cell differentiation involved in immune response (GO:0002313)2.54419487
151glycolipid catabolic process (GO:0019377)2.52605832
152regulation of antigen processing and presentation (GO:0002577)2.51597168
153negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.50843178
154regulation of gamma-delta T cell activation (GO:0046643)2.48903473
155UV protection (GO:0009650)2.46969442
156negative regulation of B cell apoptotic process (GO:0002903)2.44259265
157regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.42786807
158response to host immune response (GO:0052572)2.42780459
159response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.42780459
160negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.42260424
161lipopolysaccharide-mediated signaling pathway (GO:0031663)2.42136143
162amyloid precursor protein catabolic process (GO:0042987)2.41042304
163negative regulation of granulocyte differentiation (GO:0030853)2.38830347
164regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.37834001
165regulation of gamma-delta T cell differentiation (GO:0045586)2.37167618
166regulation of mast cell activation involved in immune response (GO:0033006)2.35777642
167purine deoxyribonucleotide catabolic process (GO:0009155)2.34454882
168glucose catabolic process (GO:0006007)2.34195954
169negative regulation of innate immune response (GO:0045824)2.33866858
170response to host (GO:0075136)2.33830690
171response to host defenses (GO:0052200)2.33830690
172response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.33830690
173regulation of superoxide anion generation (GO:0032928)2.33769471
174G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.32702457
175negative regulation of interleukin-8 production (GO:0032717)2.31676159
176defense response to protozoan (GO:0042832)2.30488224
177proline biosynthetic process (GO:0006561)2.30439093
178interferon-gamma-mediated signaling pathway (GO:0060333)2.29920898
179peptide catabolic process (GO:0043171)2.27682990
180response to interferon-beta (GO:0035456)2.27409090
181response to type I interferon (GO:0034340)2.27226074
182positive regulation of triglyceride metabolic process (GO:0090208)2.26329440
183type I interferon signaling pathway (GO:0060337)2.26193729
184cellular response to type I interferon (GO:0071357)2.26193729
185epoxygenase P450 pathway (GO:0019373)2.24321942
186pyrimidine-containing compound salvage (GO:0008655)2.23555080
187pyrimidine nucleoside salvage (GO:0043097)2.23555080
188protein kinase C signaling (GO:0070528)2.23337766
189response to protozoan (GO:0001562)2.22949663
190respiratory burst (GO:0045730)2.22187149
191negative regulation of interleukin-12 production (GO:0032695)2.21569178
192glutathione biosynthetic process (GO:0006750)2.20425319

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.74214956
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.77267137
3EGR1_23403033_ChIP-Seq_LIVER_Mouse5.97613037
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.89443535
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.91415275
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.88828793
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.62093305
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.63216920
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.59826894
10VDR_21846776_ChIP-Seq_THP-1_Human3.45178972
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.52596435
12MYC_22102868_ChIP-Seq_BL_Human2.34213823
13VDR_24763502_ChIP-Seq_THP-1_Human2.23664605
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.23010617
15ELK3_25401928_ChIP-Seq_HUVEC_Human2.19692226
16TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.05378352
17ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.6049768
18KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.99674339
19TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.97199135
20HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.95902923
21KDM2B_26808549_Chip-Seq_SUP-B15_Human1.87845878
22MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.76410062
23EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.75452734
24RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.72048923
25MAF_26560356_Chip-Seq_TH1_Human1.71888482
26TCF7_22412390_ChIP-Seq_EML_Mouse1.70064317
27KDM2B_26808549_Chip-Seq_DND41_Human1.65513385
28SCL_19346495_ChIP-Seq_HPC-7_Human1.62206213
29UTX_26944678_Chip-Seq_JUKART_Human1.62176678
30MAF_26560356_Chip-Seq_TH2_Human1.60891476
31TP63_17297297_ChIP-ChIP_HaCaT_Human1.59718858
32RUNX1_22412390_ChIP-Seq_EML_Mouse1.58958811
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.58371925
34E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.58149404
35SA1_27219007_Chip-Seq_ERYTHROID_Human1.56874122
36CTCF_27219007_Chip-Seq_ERYTHROID_Human1.55001800
37ELF1_20517297_ChIP-Seq_JURKAT_Human1.51756663
38ESR1_15608294_ChIP-ChIP_MCF-7_Human1.46282775
39RXRA_24833708_ChIP-Seq_LIVER_Mouse1.46076050
40NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.45687760
41TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.44504658
42CLOCK_20551151_ChIP-Seq_293T_Human1.42799160
43BRD4_27068464_Chip-Seq_AML-cells_Mouse1.42440636
44SPI1_23547873_ChIP-Seq_NB4_Human1.35444376
45SOX2_27498859_Chip-Seq_STOMACH_Mouse1.35213768
46SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.33599355
47NCOR1_26117541_ChIP-Seq_K562_Human1.33540196
48LXR_22292898_ChIP-Seq_THP-1_Human1.32998530
49STAT3_1855785_ChIP-Seq_MESCs_Mouse1.32104916
50SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.31090271
51SMC4_20622854_ChIP-Seq_HELA_Human1.29627610
52IRF8_21731497_ChIP-ChIP_J774_Mouse1.29406281
53HNF4A_19822575_ChIP-Seq_HepG2_Human1.29246439
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.28992096
55STAT4_19710469_ChIP-ChIP_TH1__Mouse1.27394944
56NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.26101090
57DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.25213713
58CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.24876412
59FOXA2_19822575_ChIP-Seq_HepG2_Human1.24535775
60STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.24239987
61STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.23441838
62FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.22997537
63CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22218772
64UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.21250076
65CDX2_20551321_ChIP-Seq_CACO-2_Human1.21066695
66MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.20767776
67KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.19641792
68CTCF_26484167_Chip-Seq_Bcells_Mouse1.19203824
69KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.16995274
70ZNF263_19887448_ChIP-Seq_K562_Human1.15225084
71CREB1_26743006_Chip-Seq_LNCaP_Human1.14607822
72KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.14467030
73RARG_19884340_ChIP-ChIP_MEFs_Mouse1.14426580
74CTCF_21964334_Chip-Seq_Bcells_Human1.14389231
75TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.13386367
76CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.11978242
77GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11397866
78SPI1_23127762_ChIP-Seq_K562_Human1.10983215
79TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.10635255
80CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09582859
81PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09495459
82ATF3_27146783_Chip-Seq_COLON_Human1.08997887
83ELF1_17652178_ChIP-ChIP_JURKAT_Human1.08517478
84GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.07352008
85ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.07149740
86RARA_24833708_ChIP-Seq_LIVER_Mouse1.06827613
87NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.06120367
88DNAJC2_21179169_ChIP-ChIP_NT2_Human1.03382933
89YY1_22570637_ChIP-Seq_MALME-3M_Human1.03214343
90STAT6_21828071_ChIP-Seq_BEAS2B_Human1.02936729
91SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.02666961
92RARB_24833708_ChIP-Seq_LIVER_Mouse0.98034973
93HTT_18923047_ChIP-ChIP_STHdh_Human0.97785273
94PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.97334404
95ERG_21242973_ChIP-ChIP_JURKAT_Human0.97314804
96GATA4_25053715_ChIP-Seq_YYC3_Human0.96050493
97POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.95322145
98ESR2_21235772_ChIP-Seq_MCF-7_Human0.94765304
99RACK7_27058665_Chip-Seq_MCF-7_Human0.93437216
100CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.92358422
101IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.90892609
102SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.87974248
103TET1_21451524_ChIP-Seq_MESCs_Mouse0.83832581
104RAD21_21589869_ChIP-Seq_MESCs_Mouse0.83337279
105PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.82145239
106RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.81858004
107SRY_22984422_ChIP-ChIP_TESTIS_Rat0.81853254
108POU5F1_16518401_ChIP-PET_MESCs_Mouse0.81147280
109BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.80910243
110IRF8_22096565_ChIP-ChIP_GC-B_Human0.80296118
111NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.80259145
112ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.80208981
113SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.79355256
114TCF3_18692474_ChIP-Seq_MEFs_Mouse0.78177061
115BCOR_27268052_Chip-Seq_Bcells_Human0.77799862
116ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.77444371
117PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.77344823
118GATA6_25053715_ChIP-Seq_YYC3_Human0.76973457
119NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.74128941
120SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.73343068
121BCL6_27268052_Chip-Seq_Bcells_Human0.70271930
122SOX2_18692474_ChIP-Seq_MEFs_Mouse0.69470021
123SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.68639519
124SALL4_18804426_ChIP-ChIP_XEN_Mouse0.68414490
125OCT4_18692474_ChIP-Seq_MEFs_Mouse0.67305975
126SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.66937642
127SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.66718787
128ESR1_21235772_ChIP-Seq_MCF-7_Human0.64659676
129KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.64376546
130TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.64275163
131CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.63503137
132TCF3_18692474_ChIP-Seq_MESCs_Mouse0.62933039
133CTCF_21964334_ChIP-Seq_BJAB-B_Human0.61562000
134GATA1_22025678_ChIP-Seq_K562_Human0.60543723
135GATA1_22383799_ChIP-Seq_G1ME_Mouse0.60477965
136SPI1_26923725_Chip-Seq_HPCs_Mouse0.60277307
137CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.58995775
138SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.58628342
139PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.58087599
140PU.1_20513432_ChIP-Seq_Bcells_Mouse0.57852476
141E2F1_20622854_ChIP-Seq_HELA_Human0.57467425
142KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.57004372
143KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.57004372
144KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.57004372
145PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.56542836
146GATA1_19941827_ChIP-Seq_MEL_Mouse0.56175049
147SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.55502734
148ETS1_21867929_ChIP-Seq_TH2_Mouse0.55362143
149FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.55144663
150STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.54091196
151P68_20966046_ChIP-Seq_HELA_Human0.54052214
152PHF8_20622854_ChIP-Seq_HELA_Human0.53672620
153P300_27268052_Chip-Seq_Bcells_Human0.53086273
154GATA1_19941826_ChIP-Seq_K562_Human0.52608129
155CTCF_27219007_Chip-Seq_Bcells_Human0.52587495
156EGR1_19032775_ChIP-ChIP_M12_Human0.52397379
157SA1_27219007_Chip-Seq_Bcells_Human0.52181326

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.71100569
2MP0005360_urolithiasis7.46194786
3MP0005085_abnormal_gallbladder_physiolo6.37786662
4MP0005365_abnormal_bile_salt6.09443743
5MP0008875_abnormal_xenobiotic_pharmacok4.91219897
6MP0003806_abnormal_nucleotide_metabolis4.34036038
7MP0003252_abnormal_bile_duct3.68081487
8MP0009840_abnormal_foam_cell3.46656148
9MP0010329_abnormal_lipoprotein_level3.44697601
10MP0001666_abnormal_nutrient_absorption2.95631441
11MP0003436_decreased_susceptibility_to2.86582286
12MP0005332_abnormal_amino_acid2.78653597
13MP0005083_abnormal_biliary_tract2.77096142
14MP0003303_peritoneal_inflammation2.49868460
15MP0003191_abnormal_cellular_cholesterol2.46300431
16MP0004019_abnormal_vitamin_homeostasis2.44556043
17MP0003195_calcinosis2.33959221
18MP0001835_abnormal_antigen_presentation2.26787736
19MP0005025_abnormal_response_to2.17618612
20MP0000609_abnormal_liver_physiology2.10715341
21MP0002118_abnormal_lipid_homeostasis2.05650833
22MP0003724_increased_susceptibility_to2.04625570
23MP0009278_abnormal_bone_marrow2.03941714
24MP0002419_abnormal_innate_immunity2.03835349
25MP0009333_abnormal_splenocyte_physiolog1.91106610
26MP0009785_altered_susceptibility_to1.84964084
27MP0002148_abnormal_hypersensitivity_rea1.83702437
28MP0005319_abnormal_enzyme/_coenzyme1.80197396
29MP0008260_abnormal_autophagy1.74668734
30MP0002138_abnormal_hepatobiliary_system1.74437888
31MP0005000_abnormal_immune_tolerance1.69752612
32MP0002396_abnormal_hematopoietic_system1.68349462
33MP0004947_skin_inflammation1.66218162
34MP0003172_abnormal_lysosome_physiology1.64965480
35MP0005397_hematopoietic_system_phenotyp1.64424751
36MP0001545_abnormal_hematopoietic_system1.64424751
37MP0001764_abnormal_homeostasis1.62641539
38MP0001800_abnormal_humoral_immune1.59762567
39MP0003868_abnormal_feces_composition1.59664079
40MP0002452_abnormal_antigen_presenting1.57542426
41MP0001819_abnormal_immune_cell1.57114184
42MP0002723_abnormal_immune_serum1.56851077
43MP0002420_abnormal_adaptive_immunity1.56279333
44MP0005387_immune_system_phenotype1.54618321
45MP0001790_abnormal_immune_system1.54618321
46MP0003763_abnormal_thymus_physiology1.53873479
47MP0000858_altered_metastatic_potential1.52319029
48MP0005584_abnormal_enzyme/coenzyme_acti1.46503864
49MP0000465_gastrointestinal_hemorrhage1.45979648
50MP0003183_abnormal_peptide_metabolism1.45625012
51MP0002254_reproductive_system_inflammat1.44269351
52MP0000490_abnormal_crypts_of1.43622421
53MP0001845_abnormal_inflammatory_respons1.38021056
54MP0003866_abnormal_defecation1.37116850
55MP0003656_abnormal_erythrocyte_physiolo1.36313740
56MP0003705_abnormal_hypodermis_morpholog1.35753321
57MP0009643_abnormal_urine_homeostasis1.33896024
58MP0003186_abnormal_redox_activity1.32109422
59MP0000678_abnormal_parathyroid_gland1.32003099
60MP0005451_abnormal_body_composition1.30851566
61MP0001533_abnormal_skeleton_physiology1.30293622
62MP0003300_gastrointestinal_ulcer1.27824032
63MP0005671_abnormal_response_to1.24782806
64MP0002398_abnormal_bone_marrow1.24162558
65MP0000716_abnormal_immune_system1.21951300
66MP0004185_abnormal_adipocyte_glucose1.18071022
67MP0004858_abnormal_nervous_system1.17839144
68MP0000598_abnormal_liver_morphology1.14719034
69MP0005647_abnormal_sex_gland1.13980386
70MP0002429_abnormal_blood_cell1.13543748
71MP0009697_abnormal_copulation1.11887030
72MP0002722_abnormal_immune_system1.09353047
73MP0003011_delayed_dark_adaptation1.08525816
74MP0005076_abnormal_cell_differentiation1.07108923
75MP0002405_respiratory_system_inflammati1.04549290
76MP0000689_abnormal_spleen_morphology1.02091036
77MP0001849_ear_inflammation0.98731763
78MP0001663_abnormal_digestive_system0.95650677
79MP0009931_abnormal_skin_appearance0.93881264
80MP0009379_abnormal_foot_pigmentation0.92287011
81MP0002796_impaired_skin_barrier0.91840126
82MP0005409_darkened_coat_color0.91805854
83MP0005375_adipose_tissue_phenotype0.91440078
84MP0009053_abnormal_anal_canal0.90134764
85MP0005266_abnormal_metabolism0.88932928
86MP0005636_abnormal_mineral_homeostasis0.88542896
87MP0009764_decreased_sensitivity_to0.87703154
88MP0005376_homeostasis/metabolism_phenot0.87027699
89MP0002998_abnormal_bone_remodeling0.86568052
90MP0006036_abnormal_mitochondrial_physio0.84554054
91MP0001216_abnormal_epidermal_layer0.84412148
92MP0009642_abnormal_blood_homeostasis0.83438958
93MP0000604_amyloidosis0.83198659
94MP0009763_increased_sensitivity_to0.82988721
95MP0004381_abnormal_hair_follicle0.82820998
96MP0001664_abnormal_digestion0.80922982
97MP0008004_abnormal_stomach_pH0.80469144
98MP0001851_eye_inflammation0.79162113
99MP0008469_abnormal_protein_level0.78552231
100MP0002971_abnormal_brown_adipose0.77412256
101MP0005670_abnormal_white_adipose0.74922280
102MP0010234_abnormal_vibrissa_follicle0.74602200
103MP0005220_abnormal_exocrine_pancreas0.72834246
104MP0004264_abnormal_extraembryonic_tissu0.72211282
105MP0003453_abnormal_keratinocyte_physiol0.70441514
106MP0004130_abnormal_muscle_cell0.70153299
107MP0010368_abnormal_lymphatic_system0.69568057
108MP0002078_abnormal_glucose_homeostasis0.67277780
109MP0003638_abnormal_response/metabolism_0.66715883
110MP0000639_abnormal_adrenal_gland0.65984468
111MP0000579_abnormal_nail_morphology0.65227008
112MP0005334_abnormal_fat_pad0.64584710
113MP0005084_abnormal_gallbladder_morpholo0.63431986
114MP0005448_abnormal_energy_balance0.59103307
115MP0005058_abnormal_lysosome_morphology0.58757503
116MP0009765_abnormal_xenobiotic_induced0.58659120
117MP0002060_abnormal_skin_morphology0.58157564
118MP0003075_altered_response_to0.55891582
119MP0003718_maternal_effect0.55699253
120MP0001756_abnormal_urination0.55205203
121MP0005464_abnormal_platelet_physiology0.54654458
122MP0002132_abnormal_respiratory_system0.54510186
123MP0002136_abnormal_kidney_physiology0.52372984
124MP0002876_abnormal_thyroid_physiology0.50732197
125MP0009115_abnormal_fat_cell0.48910706
126MP0005395_other_phenotype0.48664955
127MP0005666_abnormal_adipose_tissue0.47900375
128MP0003283_abnormal_digestive_organ0.47723055
129MP0005408_hypopigmentation0.47068732
130MP0005535_abnormal_body_temperature0.45068965
131MP0002249_abnormal_larynx_morphology0.42287060
132MP0003690_abnormal_glial_cell0.42154371
133MP0008873_increased_physiological_sensi0.41957982
134MP0001853_heart_inflammation0.41734126
135MP0000462_abnormal_digestive_system0.41418318
136MP0005501_abnormal_skin_physiology0.41395518
137MP0006035_abnormal_mitochondrial_morpho0.41065434
138MP0003953_abnormal_hormone_level0.40826910
139MP0006082_CNS_inflammation0.40393568
140MP0008872_abnormal_physiological_respon0.40191415
141MP0004782_abnormal_surfactant_physiolog0.39833970
142MP0003329_amyloid_beta_deposits0.39484868
143MP0008874_decreased_physiological_sensi0.39334035
144MP0001661_extended_life_span0.38754754
145MP0010030_abnormal_orbit_morphology0.38294758
146MP0005248_abnormal_Harderian_gland0.36923877
147MP0005023_abnormal_wound_healing0.35636433
148MP0002970_abnormal_white_adipose0.34969222
149MP0005166_decreased_susceptibility_to0.34500075
150MP0000467_abnormal_esophagus_morphology0.34406813
151MP0010155_abnormal_intestine_physiology0.34041460
152MP0000685_abnormal_immune_system0.32123412
153MP0000477_abnormal_intestine_morphology0.31936050
154MP0001873_stomach_inflammation0.31302302
155MP0002269_muscular_atrophy0.31211935
156MP0002822_catalepsy0.30077554

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.05328152
2Intrahepatic cholestasis (HP:0001406)6.97122719
3Deep venous thrombosis (HP:0002625)6.54964962
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.43921603
5Hypobetalipoproteinemia (HP:0003563)6.36430453
6Xanthomatosis (HP:0000991)6.02520404
7Prolonged partial thromboplastin time (HP:0003645)5.79805299
8Hyperlipoproteinemia (HP:0010980)5.12337782
9Hypolipoproteinemia (HP:0010981)4.74900065
10Hyperammonemia (HP:0001987)4.70209371
11Complement deficiency (HP:0004431)4.61150260
12Abnormality of glutamine family amino acid metabolism (HP:0010902)4.46578078
13Hyperglycinuria (HP:0003108)4.42040855
14Hyperglycinemia (HP:0002154)4.35979047
15Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.26906972
16Ketosis (HP:0001946)4.24902898
17Abnormality of sulfur amino acid metabolism (HP:0004339)4.19941572
18Joint hemorrhage (HP:0005261)4.17880680
19Fat malabsorption (HP:0002630)4.10500668
20Abnormality of glycine metabolism (HP:0010895)4.10318302
21Abnormality of serine family amino acid metabolism (HP:0010894)4.10318302
22Abnormality of aspartate family amino acid metabolism (HP:0010899)4.06588319
23Hypoalphalipoproteinemia (HP:0003233)4.06227563
24Epidermoid cyst (HP:0200040)4.05575990
25Eczematoid dermatitis (HP:0000976)4.04933239
26Abnormality of methionine metabolism (HP:0010901)3.95852862
27Abnormality of the common coagulation pathway (HP:0010990)3.85367754
28Hypoglycemic coma (HP:0001325)3.81883722
29Recurrent abscess formation (HP:0002722)3.66473276
30Abnormality of pyrimidine metabolism (HP:0004353)3.62595387
31Recurrent bacterial skin infections (HP:0005406)3.54536438
32Hypercholesterolemia (HP:0003124)3.49166667
33Abnormality of fatty-acid metabolism (HP:0004359)3.49096459
34Elevated erythrocyte sedimentation rate (HP:0003565)3.44057351
35Abnormality of complement system (HP:0005339)3.43725123
36Conjugated hyperbilirubinemia (HP:0002908)3.39122704
37Hypochromic microcytic anemia (HP:0004840)3.37303280
38Obstructive lung disease (HP:0006536)3.35035530
39Chronic obstructive pulmonary disease (HP:0006510)3.35035530
40Petechiae (HP:0000967)3.33617509
41Ketoacidosis (HP:0001993)3.28728254
42Abnormality of the intrinsic pathway (HP:0010989)3.28678516
43Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.28274987
44Hyperbilirubinemia (HP:0002904)3.26288671
45Steatorrhea (HP:0002570)3.06244345
46Myocardial infarction (HP:0001658)3.04163010
47Abnormality of nucleobase metabolism (HP:0010932)2.99591548
48Abnormality of macrophages (HP:0004311)2.99098720
49Delayed CNS myelination (HP:0002188)2.98658338
50Cellulitis (HP:0100658)2.89317149
51Abnormality of serum amino acid levels (HP:0003112)2.87762023
52Myositis (HP:0100614)2.85902465
53Increased cerebral lipofuscin (HP:0011813)2.85138569
54Abnormality of glycolipid metabolism (HP:0010969)2.82792966
55Abnormality of liposaccharide metabolism (HP:0010968)2.82792966
56Abnormality of glycosphingolipid metabolism (HP:0004343)2.82792966
57Spontaneous abortion (HP:0005268)2.82485027
58Increased IgE level (HP:0003212)2.79932661
59Abnormality of dicarboxylic acid metabolism (HP:0010995)2.79412417
60Dicarboxylic aciduria (HP:0003215)2.79412417
61Malnutrition (HP:0004395)2.76989607
62Recurrent gram-negative bacterial infections (HP:0005420)2.75639245
63Colitis (HP:0002583)2.75065712
64Metabolic acidosis (HP:0001942)2.74037292
65Lethargy (HP:0001254)2.72368037
66Increased neuronal autofluorescent lipopigment (HP:0002074)2.71943180
67Hypertensive crisis (HP:0100735)2.71929722
68Purpura (HP:0000979)2.71462424
69Increased serum ferritin (HP:0003281)2.71017445
70Abnormality of purine metabolism (HP:0004352)2.68089629
71Hepatocellular carcinoma (HP:0001402)2.64071634
72Gastrointestinal inflammation (HP:0004386)2.59093820
73Meningitis (HP:0001287)2.52886158
74Acanthocytosis (HP:0001927)2.49781835
75Vascular calcification (HP:0004934)2.49475601
76Recurrent skin infections (HP:0001581)2.48507880
77Epistaxis (HP:0000421)2.47798413
78Gout (HP:0001997)2.44362405
79Polygenic inheritance (HP:0010982)2.42639921
80Recurrent fungal infections (HP:0002841)2.41938754
81Inflammation of the large intestine (HP:0002037)2.41367524
82Prolonged bleeding time (HP:0003010)2.40234278
83Mediastinal lymphadenopathy (HP:0100721)2.39979086
84Late onset (HP:0003584)2.39236630
85Irritability (HP:0000737)2.38977691
86Hepatosplenomegaly (HP:0001433)2.38637494
87Systemic lupus erythematosus (HP:0002725)2.38033246
88Spastic diplegia (HP:0001264)2.36491854
89Ragged-red muscle fibers (HP:0003200)2.35588565
90Esophageal varix (HP:0002040)2.34403122
91Abnormality of proline metabolism (HP:0010907)2.34030993
92Hydroxyprolinuria (HP:0003080)2.34030993
93Dysostosis multiplex (HP:0000943)2.31260644
94Gingivitis (HP:0000230)2.30557102
95Hypertriglyceridemia (HP:0002155)2.29168916
96Cerebral edema (HP:0002181)2.28526698
97Skin nodule (HP:0200036)2.28481817
98Hypoglycemic seizures (HP:0002173)2.27793491
99Urticaria (HP:0001025)2.24784488
100Thin bony cortex (HP:0002753)2.22767934
101Opisthotonus (HP:0002179)2.21953815
102Alopecia of scalp (HP:0002293)2.21771511
103Cerebral palsy (HP:0100021)2.20920696
104Seborrheic dermatitis (HP:0001051)2.20332974
105Orchitis (HP:0100796)2.19811017
106Gastrointestinal infarctions (HP:0005244)2.19213732
107Abnormal gallbladder morphology (HP:0012437)2.19203598
108Cardiovascular calcification (HP:0011915)2.18923269
109Axonal loss (HP:0003447)2.18047801
110Abnormality of polysaccharide metabolism (HP:0011012)2.17732687
111Abnormality of glycosaminoglycan metabolism (HP:0004371)2.17732687
112Abnormality of mucopolysaccharide metabolism (HP:0011020)2.17732687
113Cholelithiasis (HP:0001081)2.17711936
114Recurrent viral infections (HP:0004429)2.17579256
115Polycythemia (HP:0001901)2.17160408
116Pancreatitis (HP:0001733)2.16653409
117Generalized aminoaciduria (HP:0002909)2.16181656
118Loss of speech (HP:0002371)2.15680240
119Vomiting (HP:0002013)2.15666173
120Neonatal onset (HP:0003623)2.15028792
121Agammaglobulinemia (HP:0004432)2.13582004
122Poikilocytosis (HP:0004447)2.11950523
123Chest pain (HP:0100749)2.09778162
124Amyloidosis (HP:0011034)2.09488286
125Turricephaly (HP:0000262)2.09350028
126Sensorimotor neuropathy (HP:0007141)2.09167963
127Abnormality of small intestinal villus morphology (HP:0011472)2.09066671
128Villous atrophy (HP:0011473)2.09066671
129Abnormal cartilage morphology (HP:0002763)2.08961563
130Thrombocytosis (HP:0001894)2.08625423
131Menorrhagia (HP:0000132)2.07091726
132Glomerulonephritis (HP:0000099)2.03868344
133Gingival bleeding (HP:0000225)2.03640265
134Cholecystitis (HP:0001082)2.01135864
135Abnormal gallbladder physiology (HP:0012438)2.01135864
136Gastrointestinal dysmotility (HP:0002579)1.99552047
137Abnormality of the nasal mucosa (HP:0000433)1.99190997
138Abnormality of the heme biosynthetic pathway (HP:0010472)1.98195673
139Brushfield spots (HP:0001088)1.97260910
140Recurrent cutaneous fungal infections (HP:0011370)1.96893387
141Chronic mucocutaneous candidiasis (HP:0002728)1.96893387
142Skin rash (HP:0000988)1.96531818
143Myopathic facies (HP:0002058)1.95372283
144Mucopolysacchariduria (HP:0008155)1.95088257
145Urinary glycosaminoglycan excretion (HP:0003541)1.95088257
146Bulbar palsy (HP:0001283)1.94958544
147Rickets (HP:0002748)1.94682882
148Panhypogammaglobulinemia (HP:0003139)1.94339960
149Acute hepatic failure (HP:0006554)1.94281403
150Abnormal enzyme/coenzyme activity (HP:0012379)1.93378693
151Ileus (HP:0002595)1.91390711
152Alkalosis (HP:0001948)1.90568257
153Abnormality of transition element cation homeostasis (HP:0011030)1.90543839
154Thrombophlebitis (HP:0004418)1.89047771
155Mitral stenosis (HP:0001718)1.88884904
156Enlarged kidneys (HP:0000105)1.88671222
157Easy fatigability (HP:0003388)1.88599175
158Pustule (HP:0200039)1.88262098
159Abnormality of iron homeostasis (HP:0011031)1.86528809
160Vasculitis (HP:0002633)1.85326444
161Nasal polyposis (HP:0100582)1.85158541
162Increased muscle lipid content (HP:0009058)1.83946223
163Abnormal delayed hypersensitivity skin test (HP:0002963)1.83829418
164Hemorrhage of the eye (HP:0011885)1.83201052
165Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.82523293
166Distal lower limb muscle weakness (HP:0009053)1.81982425
167Centrally nucleated skeletal muscle fibers (HP:0003687)1.81619882
168Distal lower limb amyotrophy (HP:0008944)1.81421439
169Abnormality of the gallbladder (HP:0005264)1.80866648
170Abnormality of urine glucose concentration (HP:0011016)1.80308722
171Glycosuria (HP:0003076)1.80308722
172Broad face (HP:0000283)1.78173179
173Encephalitis (HP:0002383)1.76546374
174Proximal tubulopathy (HP:0000114)1.75618561
175Growth hormone excess (HP:0000845)1.75222262
176Skin ulcer (HP:0200042)1.75093992
177Vacuolated lymphocytes (HP:0001922)1.74866341
178Reticulocytosis (HP:0001923)1.74550935
179Hyperinsulinemic hypoglycemia (HP:0000825)1.74330165
180Abnormal blistering of the skin (HP:0008066)1.74199090
181Prolonged neonatal jaundice (HP:0006579)1.71286249
182Abnormality of alkaline phosphatase activity (HP:0004379)1.70263429

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.70411213
2TAOK34.35237339
3ERN13.68130257
4MAPK153.58038590
5SIK13.46857414
6ICK3.43912279
7SMG13.26559065
8FGFR43.19493746
9TESK22.78410969
10NME22.55032232
11PINK12.47104351
12MAP3K112.38141863
13RIPK42.36863568
14PRPF4B2.34574517
15MAP3K62.29822134
16DDR22.13455069
17MAPK112.07178983
18TRIB31.87500938
19MST1R1.81358337
20ERBB41.78163185
21IRAK41.72360709
22FLT31.64373471
23DYRK1B1.58758305
24TNK21.55205557
25CSK1.54920818
26MATK1.54480309
27INSRR1.49002261
28BLK1.48686126
29MAP3K11.48651155
30ZAP701.42391591
31PKN21.40711642
32FES1.35088524
33CDK61.30544206
34VRK21.28376216
35GRK61.26844709
36BMX1.19809012
37PTK61.18751493
38LATS11.15261961
39PRKAA21.14324144
40TYK21.14261679
41TESK11.13650317
42FGR1.11552086
43PDGFRA1.08439030
44BTK1.07894645
45MAP3K131.07615913
46MAP3K31.07539239
47MAP3K101.05439451
48SCYL21.05416015
49CSF1R1.03123562
50RIPK10.99604111
51EPHB20.99159355
52IRAK20.99077415
53JAK30.98580215
54GSK3A0.98506441
55PIM20.97650770
56PIK3CG0.96818641
57TBK10.96473135
58KDR0.96416711
59PRKD20.94154336
60DAPK10.93275896
61MAP2K30.91466994
62JAK20.90081417
63MAP2K20.88736099
64IKBKB0.88387343
65TIE10.87420148
66MAP3K70.87149839
67AKT30.87013460
68FRK0.85950548
69TYRO30.85073885
70KIT0.83529573
71MAPK40.82649961
72ABL20.81685103
73PRKAA10.81240712
74MAP2K60.80771770
75EEF2K0.80388034
76SYK0.78110567
77EPHA20.77007794
78STK38L0.76357558
79MAP2K40.75724195
80TLK10.75073672
81MAP3K80.74821870
82TAOK20.73877005
83PAK40.71221803
84PIM10.69770303
85HIPK20.69692341
86ERBB20.69115808
87PTK20.68066603
88CAMK2G0.67641705
89ARAF0.66942139
90NEK90.64380112
91HCK0.63546418
92CDC42BPA0.61958619
93MET0.61623007
94PRKCZ0.60247602
95PRKACG0.59506454
96LATS20.57590026
97LRRK20.57218696
98CDK70.55999739
99LMTK20.53437633
100MTOR0.52938115
101DAPK20.52298411
102MAPK120.52173558
103MAPKAPK30.51485609
104IRAK10.51238169
105MARK20.50247154
106EPHB10.48406699
107RPS6KL10.47727981
108RPS6KC10.47727981
109PDK10.47618680
110LCK0.47321874
111PRKG20.46846702
112RPS6KA20.46443790
113RPS6KA40.45213123
114ITK0.43661539
115RPS6KA60.43177854
116PHKG20.42841066
117PHKG10.42841066
118MAPKAPK20.41973601
119SIK30.41897304
120TRPM70.41360905
121TAOK10.41044304
122PRKD30.39758895
123TGFBR20.38295116
124TTN0.38143755
125IRAK30.37999456
126EGFR0.37559161
127RPS6KA10.37543626
128STK40.33051186
129CDK40.32826559
130JAK10.32656274
131MAP3K140.32589255
132MAPK30.32240030
133MAP2K10.31898880
134IKBKE0.30278359
135RPS6KB20.29535389
136PDPK10.29424107
137PIK3CA0.28416330
138YES10.26580845
139LYN0.24116693
140PDK20.23776399
141MAP4K10.23652295
142FGFR20.22512741
143PDK30.22490358

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.13821651
2Other glycan degradation_Homo sapiens_hsa005113.49709873
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.34847123
4Nitrogen metabolism_Homo sapiens_hsa009103.25483295
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.01346425
6Arginine biosynthesis_Homo sapiens_hsa002202.97208935
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.59040527
8Tryptophan metabolism_Homo sapiens_hsa003802.59011562
9Fatty acid degradation_Homo sapiens_hsa000712.55462313
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.48197361
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.46479127
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.44822415
13Complement and coagulation cascades_Homo sapiens_hsa046102.43032747
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.40436964
15Leishmaniasis_Homo sapiens_hsa051402.16929906
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.13624884
17Allograft rejection_Homo sapiens_hsa053302.10494178
18Asthma_Homo sapiens_hsa053102.04498190
19Butanoate metabolism_Homo sapiens_hsa006502.03960542
20Peroxisome_Homo sapiens_hsa041462.01144355
21Fatty acid metabolism_Homo sapiens_hsa012122.01043695
22Chemical carcinogenesis_Homo sapiens_hsa052041.93354390
23Propanoate metabolism_Homo sapiens_hsa006401.92312308
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.91485946
25PPAR signaling pathway_Homo sapiens_hsa033201.88655748
26Histidine metabolism_Homo sapiens_hsa003401.87093829
27Autoimmune thyroid disease_Homo sapiens_hsa053201.82685348
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.81254480
29Graft-versus-host disease_Homo sapiens_hsa053321.79122197
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.78902295
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.74426426
32Sulfur metabolism_Homo sapiens_hsa009201.71162588
33Caffeine metabolism_Homo sapiens_hsa002321.70080568
34Intestinal immune network for IgA production_Homo sapiens_hsa046721.68115220
35beta-Alanine metabolism_Homo sapiens_hsa004101.65437694
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.62917207
37Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.61316724
38Retinol metabolism_Homo sapiens_hsa008301.60717744
39Selenocompound metabolism_Homo sapiens_hsa004501.55628527
40Folate biosynthesis_Homo sapiens_hsa007901.53914707
41Bile secretion_Homo sapiens_hsa049761.52045587
42Fat digestion and absorption_Homo sapiens_hsa049751.50114763
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.49138444
44Staphylococcus aureus infection_Homo sapiens_hsa051501.48977605
45Acute myeloid leukemia_Homo sapiens_hsa052211.45083383
46Phenylalanine metabolism_Homo sapiens_hsa003601.44614720
47Starch and sucrose metabolism_Homo sapiens_hsa005001.41951883
48Biosynthesis of amino acids_Homo sapiens_hsa012301.37991544
49Osteoclast differentiation_Homo sapiens_hsa043801.36965143
50Pyruvate metabolism_Homo sapiens_hsa006201.35714204
51Sulfur relay system_Homo sapiens_hsa041221.34816828
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.32197082
53Fatty acid elongation_Homo sapiens_hsa000621.31754280
54Antigen processing and presentation_Homo sapiens_hsa046121.29990205
55Tyrosine metabolism_Homo sapiens_hsa003501.27988027
56Tuberculosis_Homo sapiens_hsa051521.27833353
57Cysteine and methionine metabolism_Homo sapiens_hsa002701.26379119
58Primary immunodeficiency_Homo sapiens_hsa053401.26212064
59Type I diabetes mellitus_Homo sapiens_hsa049401.23394508
60Arginine and proline metabolism_Homo sapiens_hsa003301.23087119
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.21919301
62Fatty acid biosynthesis_Homo sapiens_hsa000611.19846114
63Carbon metabolism_Homo sapiens_hsa012001.19288227
64B cell receptor signaling pathway_Homo sapiens_hsa046621.18019703
65Maturity onset diabetes of the young_Homo sapiens_hsa049501.17314133
66ABC transporters_Homo sapiens_hsa020101.16647328
67Steroid biosynthesis_Homo sapiens_hsa001001.16439209
68Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.15489822
69Lysosome_Homo sapiens_hsa041421.14820694
70Cyanoamino acid metabolism_Homo sapiens_hsa004601.13786826
71Viral myocarditis_Homo sapiens_hsa054161.12885270
72Pertussis_Homo sapiens_hsa051331.11679650
73Toll-like receptor signaling pathway_Homo sapiens_hsa046201.08294684
74Toxoplasmosis_Homo sapiens_hsa051451.07678106
75Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.06559898
76Herpes simplex infection_Homo sapiens_hsa051681.05066269
77Influenza A_Homo sapiens_hsa051641.03175746
78RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.02247474
79Vitamin digestion and absorption_Homo sapiens_hsa049771.01483864
80Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.01334656
81Hematopoietic cell lineage_Homo sapiens_hsa046400.99060153
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94494485
83Glutathione metabolism_Homo sapiens_hsa004800.88130080
84Base excision repair_Homo sapiens_hsa034100.87208781
85NF-kappa B signaling pathway_Homo sapiens_hsa040640.85800174
86Lysine degradation_Homo sapiens_hsa003100.84236371
87Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.78653908
88Salmonella infection_Homo sapiens_hsa051320.77419833
89Notch signaling pathway_Homo sapiens_hsa043300.76796205
90Glycerolipid metabolism_Homo sapiens_hsa005610.75616535
91Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75063689
92One carbon pool by folate_Homo sapiens_hsa006700.74594203
93* Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73227777
94Vitamin B6 metabolism_Homo sapiens_hsa007500.70871727
95Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.70622967
96Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.66932450
97Leukocyte transendothelial migration_Homo sapiens_hsa046700.66188244
98Shigellosis_Homo sapiens_hsa051310.65797443
99NOD-like receptor signaling pathway_Homo sapiens_hsa046210.65149976
100Pentose phosphate pathway_Homo sapiens_hsa000300.62760970
101Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.62673451
102Fructose and mannose metabolism_Homo sapiens_hsa000510.61899028
103Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61732123
104Malaria_Homo sapiens_hsa051440.61722839
105Chronic myeloid leukemia_Homo sapiens_hsa052200.61582597
106Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.61171086
107Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59488436
108VEGF signaling pathway_Homo sapiens_hsa043700.59391923
109Galactose metabolism_Homo sapiens_hsa000520.58921363
110Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.57276493
111TNF signaling pathway_Homo sapiens_hsa046680.57191099
112Phagosome_Homo sapiens_hsa041450.55992813
113Apoptosis_Homo sapiens_hsa042100.55501032
114Non-small cell lung cancer_Homo sapiens_hsa052230.52803517
115Rheumatoid arthritis_Homo sapiens_hsa053230.52422160
116Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.51745778
117* Metabolic pathways_Homo sapiens_hsa011000.50679164
118Platelet activation_Homo sapiens_hsa046110.49989431
119Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47306465
120Pancreatic cancer_Homo sapiens_hsa052120.45069327
121Legionellosis_Homo sapiens_hsa051340.43742819
122Sphingolipid metabolism_Homo sapiens_hsa006000.43231037
123alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.39736702
124Linoleic acid metabolism_Homo sapiens_hsa005910.32366339
125Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.30754725
126Adipocytokine signaling pathway_Homo sapiens_hsa049200.21308721
127Prion diseases_Homo sapiens_hsa050200.20044247
128Glycerophospholipid metabolism_Homo sapiens_hsa005640.18804304
129Insulin resistance_Homo sapiens_hsa049310.18569848
130Mineral absorption_Homo sapiens_hsa049780.08201025
131Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.06789885
132Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.06083225
133AMPK signaling pathway_Homo sapiens_hsa041520.05482199
134Glucagon signaling pathway_Homo sapiens_hsa049220.04059328
135Renin-angiotensin system_Homo sapiens_hsa046140.03309151
136Glycosaminoglycan degradation_Homo sapiens_hsa005310.00320280
137Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2397640
138Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550-0.2354433
139Thyroid hormone synthesis_Homo sapiens_hsa04918-0.2234486
140Systemic lupus erythematosus_Homo sapiens_hsa05322-0.2059430
141African trypanosomiasis_Homo sapiens_hsa05143-0.1910280
142Protein digestion and absorption_Homo sapiens_hsa04974-0.1758030
143Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1705742
144Hepatitis C_Homo sapiens_hsa05160-0.1645554
145Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1470122
146Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.1157047
147Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1070134
148Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0598874
149Insulin signaling pathway_Homo sapiens_hsa04910-0.0581872
150Circadian rhythm_Homo sapiens_hsa04710-0.0546858
151Bladder cancer_Homo sapiens_hsa05219-0.0221782
152Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0062855

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