NARF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment. However, another role for prenylation appears to be its importance in protein-protein interactions. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins. Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif. This post-translationally modified cysteine residue is removed from prelamin A when it is endoproteolytically processed into mature lamin A. The protein encoded by this gene binds to the prenylated prelamin A carboxyl-terminal tail domain. It may be a component of a prelamin A endoprotease complex. The encoded protein is located in the nucleus, where it partially colocalizes with the nuclear lamina. It shares limited sequence similarity with iron-only bacterial hydrogenases. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene, including one with a novel exon that is generated by RNA editing. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protoporphyrinogen IX metabolic process (GO:0046501)5.90432546
2protoporphyrinogen IX biosynthetic process (GO:0006782)5.62676265
3lysine catabolic process (GO:0006554)4.63755758
4lysine metabolic process (GO:0006553)4.63755758
5cellular ketone body metabolic process (GO:0046950)4.59829697
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.59096413
7L-phenylalanine catabolic process (GO:0006559)4.59096413
8behavioral response to nicotine (GO:0035095)4.51978118
9pyrimidine nucleobase catabolic process (GO:0006208)4.33387115
10porphyrin-containing compound biosynthetic process (GO:0006779)4.22586427
11erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.18495623
12L-phenylalanine metabolic process (GO:0006558)4.18495623
13aspartate family amino acid catabolic process (GO:0009068)4.10412506
14sarcomere organization (GO:0045214)4.05498053
15ketone body metabolic process (GO:1902224)4.02376296
16glyoxylate metabolic process (GO:0046487)4.00428611
17tricarboxylic acid cycle (GO:0006099)3.94582766
18cardiac myofibril assembly (GO:0055003)3.94454688
19tetrapyrrole biosynthetic process (GO:0033014)3.91661332
20positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.86239830
21alpha-linolenic acid metabolic process (GO:0036109)3.84809962
22kynurenine metabolic process (GO:0070189)3.83807409
232-oxoglutarate metabolic process (GO:0006103)3.82394510
24aromatic amino acid family catabolic process (GO:0009074)3.81788726
25negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.79743417
26negative regulation of telomere maintenance (GO:0032205)3.77421281
27heme biosynthetic process (GO:0006783)3.72507414
28myofibril assembly (GO:0030239)3.72109256
29acetyl-CoA metabolic process (GO:0006084)3.70775126
30oxygen transport (GO:0015671)3.70018816
31triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.69018449
32nucleobase catabolic process (GO:0046113)3.68250982
33carnitine shuttle (GO:0006853)3.67151618
34response to methylmercury (GO:0051597)3.64378672
35establishment of mitochondrion localization (GO:0051654)3.64241663
36muscle filament sliding (GO:0030049)3.60664595
37actin-myosin filament sliding (GO:0033275)3.60664595
38fatty acid transmembrane transport (GO:1902001)3.56397873
39iron-sulfur cluster assembly (GO:0016226)3.54042902
40metallo-sulfur cluster assembly (GO:0031163)3.54042902
41protein-cofactor linkage (GO:0018065)3.53058743
42regulation of acyl-CoA biosynthetic process (GO:0050812)3.51529249
43porphyrin-containing compound metabolic process (GO:0006778)3.51104429
44regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.51090317
45positive regulation of mitochondrial fission (GO:0090141)3.49586532
46protein polyglutamylation (GO:0018095)3.48151916
47mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.43925143
48mitochondrial respiratory chain complex I assembly (GO:0032981)3.43925143
49NADH dehydrogenase complex assembly (GO:0010257)3.43925143
50regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.43389420
51short-chain fatty acid metabolic process (GO:0046459)3.41010524
52bile acid biosynthetic process (GO:0006699)3.40793551
53melanin biosynthetic process (GO:0042438)3.40280884
54DNA methylation involved in gamete generation (GO:0043046)3.38931735
55regulation of sarcomere organization (GO:0060297)3.34049554
56protein complex biogenesis (GO:0070271)3.33051171
57secondary metabolite biosynthetic process (GO:0044550)3.28735362
58fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.28481410
59gas transport (GO:0015669)3.26593383
60synaptic transmission, cholinergic (GO:0007271)3.25034449
61dicarboxylic acid biosynthetic process (GO:0043650)3.24191985
62negative regulation of potassium ion transmembrane transport (GO:1901380)3.23709508
63indole-containing compound catabolic process (GO:0042436)3.22665807
64indolalkylamine catabolic process (GO:0046218)3.22665807
65tryptophan catabolic process (GO:0006569)3.22665807
66ATP synthesis coupled proton transport (GO:0015986)3.21207869
67energy coupled proton transport, down electrochemical gradient (GO:0015985)3.21207869
68negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.20585343
69cardiac muscle hypertrophy (GO:0003300)3.20063798
70creatine metabolic process (GO:0006600)3.16405116
71glutamate metabolic process (GO:0006536)3.16260267
72cardiac muscle contraction (GO:0060048)3.14453112
73regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.14446121
74regulation of cofactor metabolic process (GO:0051193)3.13382908
75regulation of coenzyme metabolic process (GO:0051196)3.13382908
76response to mercury ion (GO:0046689)3.12127560
77heme metabolic process (GO:0042168)3.11701877
78coenzyme catabolic process (GO:0009109)3.10138184
79fatty acid beta-oxidation (GO:0006635)3.09894070
80regulation of skeletal muscle contraction (GO:0014819)3.09117975
81negative regulation of fibrinolysis (GO:0051918)3.08759338
82negative regulation of protein localization to cell surface (GO:2000009)3.08310236
83mitochondrial respiratory chain complex assembly (GO:0033108)3.08291461
84mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.06929317
85tryptophan metabolic process (GO:0006568)3.05248722
86ethanol oxidation (GO:0006069)3.05120690
87regulation of cell communication by electrical coupling (GO:0010649)3.04154612
88striated muscle hypertrophy (GO:0014897)3.03828509
89base-excision repair, AP site formation (GO:0006285)3.02662363
90cysteine metabolic process (GO:0006534)3.01451412
91high-density lipoprotein particle remodeling (GO:0034375)2.99968745
92piRNA metabolic process (GO:0034587)2.99217491
93establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.99167104
94mitochondrion transport along microtubule (GO:0047497)2.99167104
95heme transport (GO:0015886)2.98095230
96melanin metabolic process (GO:0006582)2.96398173
97male meiosis I (GO:0007141)2.96285991
98mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.95872054
99regulation of cilium movement (GO:0003352)2.95726468
100synapsis (GO:0007129)2.95253276
101resolution of meiotic recombination intermediates (GO:0000712)2.94410731
102tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.94108699
103RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.94108699
104fatty acid catabolic process (GO:0009062)2.93844210
105regulation of triglyceride catabolic process (GO:0010896)2.93095734
106regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.92935666
107oxaloacetate metabolic process (GO:0006107)2.92791835
108alpha-amino acid catabolic process (GO:1901606)2.92064220
109regulation of fibrinolysis (GO:0051917)2.91367937
110negative regulation of transcription regulatory region DNA binding (GO:2000678)2.90982277
111urea metabolic process (GO:0019627)2.89892141
112urea cycle (GO:0000050)2.89892141
113pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.89264458
114succinate metabolic process (GO:0006105)2.89035233
115dicarboxylic acid catabolic process (GO:0043649)2.88939488
116NADH metabolic process (GO:0006734)2.88725968
117DNA deamination (GO:0045006)2.88630891
118cardiac muscle adaptation (GO:0014887)2.87477157
119cardiac muscle hypertrophy in response to stress (GO:0014898)2.87477157
120muscle hypertrophy in response to stress (GO:0003299)2.87477157
121thioester biosynthetic process (GO:0035384)2.87268187
122acyl-CoA biosynthetic process (GO:0071616)2.87268187
123regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.86433629
124actin-mediated cell contraction (GO:0070252)2.85375960
125monocarboxylic acid catabolic process (GO:0072329)2.85146707
126fatty acid oxidation (GO:0019395)2.82767226
127carnitine transmembrane transport (GO:1902603)2.82022804
128striated muscle contraction (GO:0006941)2.81798866
129amino-acid betaine metabolic process (GO:0006577)2.81763572
130glycogen catabolic process (GO:0005980)2.81700029
131positive regulation of fatty acid beta-oxidation (GO:0032000)2.78861679
132erythrocyte maturation (GO:0043249)2.78346424
133sarcoplasmic reticulum calcium ion transport (GO:0070296)2.78091263
134erythrocyte development (GO:0048821)2.76972578
135lipid oxidation (GO:0034440)2.76399645
136protein localization to cilium (GO:0061512)2.76205492
137phospholipid homeostasis (GO:0055091)2.74907385
138regulation of protein activation cascade (GO:2000257)2.73837660
139regulation of sulfur metabolic process (GO:0042762)2.73651920
140replication fork processing (GO:0031297)2.73591601
141bile acid metabolic process (GO:0008206)2.72959621
142tyrosine metabolic process (GO:0006570)2.70751757
143electron transport chain (GO:0022900)2.68260035
144meiotic chromosome segregation (GO:0045132)2.68012272
145respiratory electron transport chain (GO:0022904)2.67942314
146negative regulation of DNA-templated transcription, elongation (GO:0032785)2.66758904
147ubiquinone biosynthetic process (GO:0006744)2.64558872
148ubiquinone metabolic process (GO:0006743)2.63391580
149male meiosis (GO:0007140)2.63272888
150regulation of microtubule-based movement (GO:0060632)2.62524575
151cell migration in hindbrain (GO:0021535)2.61634370
152mannosylation (GO:0097502)2.60804031
153pyrimidine dimer repair (GO:0006290)2.60761957
154ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.60467561
155centriole replication (GO:0007099)2.59162768
156deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.57268704
157pyrimidine nucleotide catabolic process (GO:0006244)2.56409490
158reciprocal DNA recombination (GO:0035825)2.55613263
159reciprocal meiotic recombination (GO:0007131)2.55613263
160intraciliary transport (GO:0042073)2.55511567
161pigment biosynthetic process (GO:0046148)2.54841615
162regulation of telomere maintenance (GO:0032204)2.54407389
163meiosis I (GO:0007127)2.52401830
164postsynaptic membrane organization (GO:0001941)2.51896640
165sequestering of actin monomers (GO:0042989)2.49631573
166preassembly of GPI anchor in ER membrane (GO:0016254)2.48985883
167spinal cord association neuron differentiation (GO:0021527)2.46496726
168nonmotile primary cilium assembly (GO:0035058)2.45217572
169neurofilament cytoskeleton organization (GO:0060052)2.43424443
170epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.42981608
171epithelial cilium movement (GO:0003351)2.41615133
172microtubule depolymerization (GO:0007019)2.41407795
173response to misfolded protein (GO:0051788)2.41189715
174chaperone-mediated protein transport (GO:0072321)2.41153660
175regulation of double-strand break repair via homologous recombination (GO:0010569)2.40299587
176protein deneddylation (GO:0000338)2.39294684
177regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.37698095
178mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.36876062
179positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.36876062
180transmission of nerve impulse (GO:0019226)2.36051184
181regulation of mitochondrial fission (GO:0090140)2.34096058
182head development (GO:0060322)2.33937752
183somatic hypermutation of immunoglobulin genes (GO:0016446)2.33624739
184somatic diversification of immune receptors via somatic mutation (GO:0002566)2.33624739
185DNA alkylation (GO:0006305)2.33344080
186DNA methylation (GO:0006306)2.33344080
187isoprenoid biosynthetic process (GO:0008299)2.32674837
188ATP hydrolysis coupled proton transport (GO:0015991)2.30967396
189energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.30967396
190organelle disassembly (GO:1903008)2.28734278
191DNA methylation or demethylation (GO:0044728)2.28672355

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.43378033
2* RXR_22158963_ChIP-Seq_LIVER_Mouse4.04442047
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.92214717
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.46848173
5* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.42561735
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.23739041
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.20345055
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.06509325
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.05481601
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.01347007
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.93637143
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.84229412
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.80829054
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.76493801
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.76303390
16TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.67366699
17EGR1_23403033_ChIP-Seq_LIVER_Mouse2.66847496
18EZH2_22144423_ChIP-Seq_EOC_Human2.60593037
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.57271023
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.42228182
21ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.36028591
22THAP11_20581084_ChIP-Seq_MESCs_Mouse2.34506254
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.26246121
24GBX2_23144817_ChIP-Seq_PC3_Human2.23633541
25* PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.14235064
26SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.13254183
27TAF15_26573619_Chip-Seq_HEK293_Human2.12774306
28GATA1_22025678_ChIP-Seq_K562_Human2.11882984
29IGF1R_20145208_ChIP-Seq_DFB_Human2.11385838
30* VDR_23849224_ChIP-Seq_CD4+_Human2.09566230
31CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.09540590
32* SRF_21415370_ChIP-Seq_HL-1_Mouse2.06228850
33IRF1_19129219_ChIP-ChIP_H3396_Human2.06088735
34GABP_19822575_ChIP-Seq_HepG2_Human2.05429634
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.03078133
36* GATA1_19941826_ChIP-Seq_K562_Human1.97753824
37FOXP3_21729870_ChIP-Seq_TREG_Human1.96020535
38AR_21572438_ChIP-Seq_LNCaP_Human1.95061628
39SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.94317109
40* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.93954561
41SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.85143262
42ESR1_20079471_ChIP-ChIP_T-47D_Human1.85069037
43CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.84761477
44E2F4_17652178_ChIP-ChIP_JURKAT_Human1.78817634
45RBPJ_22232070_ChIP-Seq_NCS_Mouse1.77439349
46* YY1_21170310_ChIP-Seq_MESCs_Mouse1.76770941
47GATA1_19941827_ChIP-Seq_MEL_Mouse1.76718675
48CIITA_25753668_ChIP-Seq_RAJI_Human1.76099164
49XRN2_22483619_ChIP-Seq_HELA_Human1.75171501
50KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.72972363
51CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.71398137
52MYC_18358816_ChIP-ChIP_MESCs_Mouse1.70116658
53JARID2_20064375_ChIP-Seq_MESCs_Mouse1.69234763
54MTF2_20144788_ChIP-Seq_MESCs_Mouse1.67293800
55MYC_18940864_ChIP-ChIP_HL60_Human1.66765599
56RARB_27405468_Chip-Seq_BRAIN_Mouse1.65032837
57NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.64323736
58RNF2_18974828_ChIP-Seq_MESCs_Mouse1.63387541
59EZH2_18974828_ChIP-Seq_MESCs_Mouse1.63387541
60THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.60871688
61VDR_22108803_ChIP-Seq_LS180_Human1.60478986
62E2F7_22180533_ChIP-Seq_HELA_Human1.58371286
63MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.58365249
64EZH2_27294783_Chip-Seq_ESCs_Mouse1.58024582
65EP300_21415370_ChIP-Seq_HL-1_Mouse1.55862676
66TTF2_22483619_ChIP-Seq_HELA_Human1.55817605
67PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54854889
68SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.53194598
69PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.49945798
70TP53_22573176_ChIP-Seq_HFKS_Human1.48763483
71CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.48321641
72SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.46400508
73EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.44969261
74EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.44084695
75REST_18959480_ChIP-ChIP_MESCs_Mouse1.43893906
76ERG_21242973_ChIP-ChIP_JURKAT_Human1.43619233
77ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.43521076
78* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.43093115
79SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.42856650
80TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40550231
81JARID2_20075857_ChIP-Seq_MESCs_Mouse1.40451165
82SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.40009682
83ZNF263_19887448_ChIP-Seq_K562_Human1.39922507
84DNAJC2_21179169_ChIP-ChIP_NT2_Human1.39919273
85DROSHA_22980978_ChIP-Seq_HELA_Human1.39863566
86TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.38910143
87EZH2_27304074_Chip-Seq_ESCs_Mouse1.38875971
88EED_16625203_ChIP-ChIP_MESCs_Mouse1.38612929
89* KDM5A_27292631_Chip-Seq_BREAST_Human1.38174905
90SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.36872292
91CTBP1_25329375_ChIP-Seq_LNCAP_Human1.36601509
92DCP1A_22483619_ChIP-Seq_HELA_Human1.36519093
93SUZ12_27294783_Chip-Seq_ESCs_Mouse1.33346497
94BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.31284031
95ELK1_19687146_ChIP-ChIP_HELA_Human1.30988703
96* GATA2_19941826_ChIP-Seq_K562_Human1.30331873
97SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.28255999
98REST_21632747_ChIP-Seq_MESCs_Mouse1.28225130
99FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.27178165
100HTT_18923047_ChIP-ChIP_STHdh_Human1.26372088
101SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25367484
102* FOXA2_19822575_ChIP-Seq_HepG2_Human1.24989488
103* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23998346
104FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.22969379
105TBX20_22080862_ChIP-Seq_HEART_Mouse1.22252762
106TBX20_22328084_ChIP-Seq_HEART_Mouse1.22252762
107BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.21190694
108MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.20630138
109SOX2_21211035_ChIP-Seq_LN229_Gbm1.20380782
110BCL6_27268052_Chip-Seq_Bcells_Human1.20372517
111MYC_18555785_ChIP-Seq_MESCs_Mouse1.20208557
112YY1_22570637_ChIP-Seq_MALME-3M_Human1.18691529
113FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.18166102
114HOXB4_20404135_ChIP-ChIP_EML_Mouse1.18053150
115EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.16863173
116CTBP2_25329375_ChIP-Seq_LNCAP_Human1.16323165
117* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.15372410
118SMAD3_21741376_ChIP-Seq_EPCs_Human1.14841786
119MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.12947548
120CTCF_27219007_Chip-Seq_Bcells_Human1.12521115
121RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.11541098
122ETV2_25802403_ChIP-Seq_MESCs_Mouse1.11422146
123ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09987306
124ERA_21632823_ChIP-Seq_H3396_Human1.09936827
125E2F1_17053090_ChIP-ChIP_MCF-7_Human1.09096779
126FOXP1_21924763_ChIP-Seq_HESCs_Human1.08644131
127POU3F2_20337985_ChIP-ChIP_501MEL_Human1.08483394
128ELF1_20517297_ChIP-Seq_JURKAT_Human1.08156473
129ZNF274_21170338_ChIP-Seq_K562_Hela1.07679531
130FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.06932230
131CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.05977780
132PHF8_20622854_ChIP-Seq_HELA_Human1.05528162
133RNF2_27304074_Chip-Seq_NSC_Mouse1.05333722
134E2F1_18555785_ChIP-Seq_MESCs_Mouse1.05257841
135SOX2_16153702_ChIP-ChIP_HESCs_Human1.03556070
136RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.03486755
137CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.03037985
138CLOCK_20551151_ChIP-Seq_293T_Human1.02466511
139EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02445528
140SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.02172913
141TP63_19390658_ChIP-ChIP_HaCaT_Human1.01864780
142E2F1_20622854_ChIP-Seq_HELA_Human1.01682241
143TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.00902156
144CBX2_27304074_Chip-Seq_ESCs_Mouse1.00662161
145MYC_19030024_ChIP-ChIP_MESCs_Mouse0.99758152
146* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.98358603
147PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.98282569
148NR3C1_23031785_ChIP-Seq_PC12_Mouse0.98156218
149TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97595485
150RNF2_27304074_Chip-Seq_ESCs_Mouse0.96910010
151GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95190291
152NANOG_20526341_ChIP-Seq_ESCs_Human0.94584995
153GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94200505
154PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.93875750
155* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93128215
156E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92625483
157NCOR_22424771_ChIP-Seq_293T_Human0.92294425
158NELFA_20434984_ChIP-Seq_ESCs_Mouse0.91014681
159MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.90594082
160SMAD4_21799915_ChIP-Seq_A2780_Human0.90353421
161RAC3_21632823_ChIP-Seq_H3396_Human0.90163996
162FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.89387855
163* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.88879569
164POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.87889395
165GATA3_21878914_ChIP-Seq_MCF-7_Human0.87363544
166GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.87109476
167MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.86719757
168OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86549512
169ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.85836745
170PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.84716101
171P53_21459846_ChIP-Seq_SAOS-2_Human0.84201494
172SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.83660486
173WT1_25993318_ChIP-Seq_PODOCYTE_Human0.83262456
174WT1_19549856_ChIP-ChIP_CCG9911_Human0.82604436
175P300_19829295_ChIP-Seq_ESCs_Human0.82589127
176ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.82501885
177* AR_19668381_ChIP-Seq_PC3_Human0.82498740
178CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.82424306
179SMAD4_21741376_ChIP-Seq_HESCs_Human0.81621396
180* KDM2B_26808549_Chip-Seq_K562_Human0.80829273
181TOP2B_26459242_ChIP-Seq_MCF-7_Human0.80747812
182CDX2_19796622_ChIP-Seq_MESCs_Mouse0.80710404
183CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.79214602
184NRF2_20460467_ChIP-Seq_MEFs_Mouse0.77457200
185NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.77457200
186GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76968191
187WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.76817259
188AR_25329375_ChIP-Seq_VCAP_Human0.76729455
189SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75907871
190PIAS1_25552417_ChIP-Seq_VCAP_Human0.75246880

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.83184501
2MP0002139_abnormal_hepatobiliary_system4.32637515
3MP0003656_abnormal_erythrocyte_physiolo4.04300818
4MP0005360_urolithiasis4.00309113
5MP0004147_increased_porphyrin_level3.98134674
6MP0000372_irregular_coat_pigmentation3.86491833
7MP0005085_abnormal_gallbladder_physiolo3.51167523
8MP0000751_myopathy3.21929132
9MP0003646_muscle_fatigue3.11002223
10MP0004215_abnormal_myocardial_fiber2.99613818
11MP0005365_abnormal_bile_salt2.95694882
12MP0008995_early_reproductive_senescence2.83671265
13MP0002102_abnormal_ear_morphology2.75060848
14MP0005083_abnormal_biliary_tract2.70720578
15MP0000749_muscle_degeneration2.67712817
16MP0004036_abnormal_muscle_relaxation2.63660225
17MP0004084_abnormal_cardiac_muscle2.63168446
18MP0002653_abnormal_ependyma_morphology2.54460352
19MP0006276_abnormal_autonomic_nervous2.53881157
20MP0003806_abnormal_nucleotide_metabolis2.48917894
21MP0008877_abnormal_DNA_methylation2.43634447
22MP0003136_yellow_coat_color2.42025416
23MP0004130_abnormal_muscle_cell2.40575274
24MP0006292_abnormal_olfactory_placode2.37310065
25MP0008058_abnormal_DNA_repair2.35739519
26MP0003787_abnormal_imprinting2.35480095
27MP0008875_abnormal_xenobiotic_pharmacok2.30468269
28MP0004270_analgesia2.28270801
29MP0002638_abnormal_pupillary_reflex2.24602283
30MP0004145_abnormal_muscle_electrophysio2.19933505
31MP0008789_abnormal_olfactory_epithelium2.06216995
32MP0005499_abnormal_olfactory_system2.04730985
33MP0005394_taste/olfaction_phenotype2.04730985
34MP0005330_cardiomyopathy2.04566831
35MP0004859_abnormal_synaptic_plasticity1.99989934
36MP0005620_abnormal_muscle_contractility1.89804931
37MP0005171_absent_coat_pigmentation1.89713891
38MP0010329_abnormal_lipoprotein_level1.88012728
39MP0004087_abnormal_muscle_fiber1.87078513
40MP0002095_abnormal_skin_pigmentation1.85832425
41MP0008775_abnormal_heart_ventricle1.81398667
42MP0006036_abnormal_mitochondrial_physio1.80710053
43MP0005075_abnormal_melanosome_morpholog1.79249864
44MP0003137_abnormal_impulse_conducting1.78101313
45MP0000747_muscle_weakness1.77807899
46MP0000015_abnormal_ear_pigmentation1.73575751
47MP0003121_genomic_imprinting1.67897770
48MP0002972_abnormal_cardiac_muscle1.66987985
49MP0002269_muscular_atrophy1.66318065
50MP0003252_abnormal_bile_duct1.63626147
51MP0003329_amyloid_beta_deposits1.60209486
52MP0005377_hearing/vestibular/ear_phenot1.54401072
53MP0003878_abnormal_ear_physiology1.54401072
54MP0003880_abnormal_central_pattern1.54005144
55MP0002106_abnormal_muscle_physiology1.50542753
56MP0005645_abnormal_hypothalamus_physiol1.50184452
57MP0003122_maternal_imprinting1.47320142
58MP0004085_abnormal_heartbeat1.46552895
59MP0001986_abnormal_taste_sensitivity1.44103007
60MP0000759_abnormal_skeletal_muscle1.43954580
61MP0001529_abnormal_vocalization1.41057462
62MP0002822_catalepsy1.39981612
63MP0003221_abnormal_cardiomyocyte_apopto1.36159137
64MP0003635_abnormal_synaptic_transmissio1.36152548
65MP0005253_abnormal_eye_physiology1.30458270
66MP0005332_abnormal_amino_acid1.29402279
67MP0005385_cardiovascular_system_phenoty1.28955092
68MP0001544_abnormal_cardiovascular_syste1.28955092
69MP0001666_abnormal_nutrient_absorption1.28914722
70MP0002938_white_spotting1.27392907
71MP0001324_abnormal_eye_pigmentation1.23254506
72MP0002118_abnormal_lipid_homeostasis1.22889749
73MP0006035_abnormal_mitochondrial_morpho1.22712072
74MP0005369_muscle_phenotype1.20995824
75MP0004233_abnormal_muscle_weight1.19778733
76MP0002735_abnormal_chemical_nociception1.17009422
77MP0004484_altered_response_of1.16221767
78MP0010630_abnormal_cardiac_muscle1.15178758
79MP0003786_premature_aging1.15029879
80MP0010094_abnormal_chromosome_stability1.14585306
81MP0004133_heterotaxia1.13895200
82MP0005584_abnormal_enzyme/coenzyme_acti1.13675715
83MP0002064_seizures1.13130508
84MP0005386_behavior/neurological_phenoty1.11000600
85MP0004924_abnormal_behavior1.11000600
86MP0004885_abnormal_endolymph1.10523300
87MP0009745_abnormal_behavioral_response1.09645583
88MP0002063_abnormal_learning/memory/cond1.09419940
89MP0005084_abnormal_gallbladder_morpholo1.09043270
90MP0005451_abnormal_body_composition1.08923041
91MP0008872_abnormal_physiological_respon1.08474106
92MP0005551_abnormal_eye_electrophysiolog1.08105427
93MP0002736_abnormal_nociception_after1.08104001
94MP0003186_abnormal_redox_activity1.07195524
95MP0003718_maternal_effect1.06504776
96MP0000631_abnormal_neuroendocrine_gland1.05779881
97MP0006138_congestive_heart_failure1.05626256
98MP0002210_abnormal_sex_determination1.04551275
99MP0003698_abnormal_male_reproductive1.04285815
100MP0009840_abnormal_foam_cell1.04128275
101MP0002557_abnormal_social/conspecific_i1.03713421
102MP0001984_abnormal_olfaction1.03612172
103MP0002272_abnormal_nervous_system1.02169089
104MP0001545_abnormal_hematopoietic_system0.99991637
105MP0005397_hematopoietic_system_phenotyp0.99991637
106MP0002733_abnormal_thermal_nociception0.99536837
107MP0002332_abnormal_exercise_endurance0.99421843
108MP0001929_abnormal_gametogenesis0.98926332
109MP0004742_abnormal_vestibular_system0.98255896
110MP0001970_abnormal_pain_threshold0.97593887
111MP0000920_abnormal_myelination0.96848251
112MP0000604_amyloidosis0.96743396
113MP0006072_abnormal_retinal_apoptosis0.96720747
114MP0000609_abnormal_liver_physiology0.95972150
115MP0001905_abnormal_dopamine_level0.95189495
116MP0003195_calcinosis0.94513178
117MP0001188_hyperpigmentation0.93214256
118MP0003111_abnormal_nucleus_morphology0.92829220
119MP0002752_abnormal_somatic_nervous0.91009508
120MP0002928_abnormal_bile_duct0.90304864
121MP0005319_abnormal_enzyme/_coenzyme0.88679368
122MP0001486_abnormal_startle_reflex0.88302535
123MP0002882_abnormal_neuron_morphology0.88129039
124MP0002067_abnormal_sensory_capabilities0.87854634
125MP0000778_abnormal_nervous_system0.86129289
126MP0009278_abnormal_bone_marrow0.86111197
127MP0004043_abnormal_pH_regulation0.84934481
128MP0002132_abnormal_respiratory_system0.82358836
129MP0003868_abnormal_feces_composition0.82092662
130MP0005666_abnormal_adipose_tissue0.81977503
131MP0002229_neurodegeneration0.80624613
132MP0009046_muscle_twitch0.80154905
133MP0002971_abnormal_brown_adipose0.79874105
134MP0001502_abnormal_circadian_rhythm0.79702632
135MP0005646_abnormal_pituitary_gland0.79236614
136MP0005187_abnormal_penis_morphology0.78985692
137MP0003693_abnormal_embryo_hatching0.78692056
138MP0004142_abnormal_muscle_tone0.78507054
139MP0001293_anophthalmia0.77394245
140MP0005423_abnormal_somatic_nervous0.77153746
141MP0008874_decreased_physiological_sensi0.77064982
142MP0002090_abnormal_vision0.76436214
143MP0002572_abnormal_emotion/affect_behav0.76343739
144MP0005535_abnormal_body_temperature0.76215666
145MP0000049_abnormal_middle_ear0.75531248
146MP0005636_abnormal_mineral_homeostasis0.74970135
147MP0002751_abnormal_autonomic_nervous0.74594930
148MP0000653_abnormal_sex_gland0.74590196
149MP0003567_abnormal_fetal_cardiomyocyte0.72392666
150MP0002184_abnormal_innervation0.71336131
151MP0001485_abnormal_pinna_reflex0.71014521
152MP0005174_abnormal_tail_pigmentation0.70902940
153MP0008569_lethality_at_weaning0.70290959
154MP0002734_abnormal_mechanical_nocicepti0.70131753
155MP0004185_abnormal_adipocyte_glucose0.69834776
156MP0001440_abnormal_grooming_behavior0.69297541
157MP0003011_delayed_dark_adaptation0.69079388
158MP0005266_abnormal_metabolism0.68441344
159MP0003690_abnormal_glial_cell0.67706483
160MP0002127_abnormal_cardiovascular_syste0.66681750
161MP0000750_abnormal_muscle_regeneration0.66548840
162MP0002066_abnormal_motor_capabilities/c0.66186944
163MP0002078_abnormal_glucose_homeostasis0.65422981
164MP0001968_abnormal_touch/_nociception0.65170887
165MP0003950_abnormal_plasma_membrane0.63982036
166MP0000955_abnormal_spinal_cord0.63201503
167MP0004811_abnormal_neuron_physiology0.63099283
168MP0001764_abnormal_homeostasis0.63098870

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)5.04198275
2Exercise-induced muscle cramps (HP:0003710)4.76291739
3Abnormality of the heme biosynthetic pathway (HP:0010472)4.57756755
4Poikilocytosis (HP:0004447)4.49980447
5Cholelithiasis (HP:0001081)4.13011435
6Sudden death (HP:0001699)4.11139466
7Muscle hypertrophy of the lower extremities (HP:0008968)4.00190141
8Abnormal gallbladder morphology (HP:0012437)3.88093832
9Calf muscle hypertrophy (HP:0008981)3.85872486
10Myoglobinuria (HP:0002913)3.77187643
11Hypochromic microcytic anemia (HP:0004840)3.72562526
12Deep venous thrombosis (HP:0002625)3.63142821
13Acanthocytosis (HP:0001927)3.46735986
14Cholecystitis (HP:0001082)3.42593400
15Abnormal gallbladder physiology (HP:0012438)3.42593400
16Hepatoblastoma (HP:0002884)3.39134638
17Hyporeflexia of lower limbs (HP:0002600)3.37673082
18Reticulocytosis (HP:0001923)3.32384978
19Ketosis (HP:0001946)3.30260703
20Muscle fiber splitting (HP:0003555)3.12645443
21Abnormality of the calf musculature (HP:0001430)3.11380090
22Hyperbilirubinemia (HP:0002904)3.07972933
23Intrahepatic cholestasis (HP:0001406)3.06862559
24Pancreatic cysts (HP:0001737)3.06356947
25Ketoacidosis (HP:0001993)3.01146026
26Abnormality of reticulocytes (HP:0004312)2.99569015
27Acute necrotizing encephalopathy (HP:0006965)2.97914737
28Pancreatic fibrosis (HP:0100732)2.96699945
29Abnormality of the labia minora (HP:0012880)2.94735900
30Hyperlipoproteinemia (HP:0010980)2.93050197
31Birth length less than 3rd percentile (HP:0003561)2.90648101
32Medial flaring of the eyebrow (HP:0010747)2.84185231
33Hypobetalipoproteinemia (HP:0003563)2.82846919
34Abnormality of aromatic amino acid family metabolism (HP:0004338)2.80524410
35Ventricular tachycardia (HP:0004756)2.78414804
36Mitochondrial inheritance (HP:0001427)2.77724382
37True hermaphroditism (HP:0010459)2.77226690
38Retinal dysplasia (HP:0007973)2.76505439
39Rhabdomyolysis (HP:0003201)2.75351764
40Abnormality of midbrain morphology (HP:0002418)2.75228358
41Molar tooth sign on MRI (HP:0002419)2.75228358
42Xanthomatosis (HP:0000991)2.74024110
43Abnormality of the gallbladder (HP:0005264)2.72379183
44Gait imbalance (HP:0002141)2.72269564
45EMG: myopathic abnormalities (HP:0003458)2.70393105
46Hyperammonemia (HP:0001987)2.69963596
47Increased CSF lactate (HP:0002490)2.68792503
48Atrial fibrillation (HP:0005110)2.67751132
49Congenital stationary night blindness (HP:0007642)2.64079426
50Lissencephaly (HP:0001339)2.62291289
51Increased serum pyruvate (HP:0003542)2.54719715
52Abnormality of glycolysis (HP:0004366)2.54719715
53Abnormal number of erythroid precursors (HP:0012131)2.54172102
54Neoplasm of the adrenal gland (HP:0100631)2.53143591
55Hyperventilation (HP:0002883)2.51328717
56Nephronophthisis (HP:0000090)2.50940230
57Congenital primary aphakia (HP:0007707)2.49756050
58Prolonged partial thromboplastin time (HP:0003645)2.49175158
59Primary atrial arrhythmia (HP:0001692)2.47910019
60Difficulty running (HP:0009046)2.47589913
61Abnormal hemoglobin (HP:0011902)2.45680986
62Nephrogenic diabetes insipidus (HP:0009806)2.45400322
63Abnormality of fatty-acid metabolism (HP:0004359)2.45349576
64Abnormality of the corticospinal tract (HP:0002492)2.41741904
65Subaortic stenosis (HP:0001682)2.41446488
66Abnormality of the left ventricular outflow tract (HP:0011103)2.41446488
67Muscle fiber inclusion bodies (HP:0100299)2.41388746
68Lipoatrophy (HP:0100578)2.39376121
69Paralysis (HP:0003470)2.38899655
70Degeneration of the lateral corticospinal tracts (HP:0002314)2.38546039
71Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.38546039
72Supraventricular tachycardia (HP:0004755)2.38135185
73Polyphagia (HP:0002591)2.37715122
74Pheochromocytoma (HP:0002666)2.35839121
75Progressive macrocephaly (HP:0004481)2.34682709
76Cerebral edema (HP:0002181)2.33990269
77Hypolipoproteinemia (HP:0010981)2.31820782
78Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.31284094
79Prolonged QT interval (HP:0001657)2.29972921
80Supraventricular arrhythmia (HP:0005115)2.29925466
81Abnormality of cells of the erythroid lineage (HP:0012130)2.28397591
82Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.28082466
83Diaphragmatic weakness (HP:0009113)2.27905960
84Urinary urgency (HP:0000012)2.26965471
85Palpitations (HP:0001962)2.26822051
86Muscle stiffness (HP:0003552)2.26607592
87Patellar aplasia (HP:0006443)2.26345691
88Metabolic acidosis (HP:0001942)2.25385694
89Myotonia (HP:0002486)2.20932215
90Hypoalphalipoproteinemia (HP:0003233)2.20155393
91Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.17727379
92Type II lissencephaly (HP:0007260)2.17702078
93Neuroendocrine neoplasm (HP:0100634)2.15541231
94Cystic liver disease (HP:0006706)2.14147473
95Aplasia/Hypoplasia of the fovea (HP:0008060)2.13693517
96Hypoplasia of the fovea (HP:0007750)2.13693517
97Hepatocellular carcinoma (HP:0001402)2.13357607
98Aplasia/Hypoplasia of the patella (HP:0006498)2.12186868
99Hypoglycemic coma (HP:0001325)2.11563920
100Dicarboxylic aciduria (HP:0003215)2.10437110
101Abnormality of dicarboxylic acid metabolism (HP:0010995)2.10437110
102Abnormality of monocarboxylic acid metabolism (HP:0010996)2.10263017
103Reticulocytopenia (HP:0001896)2.10202733
104Neonatal hypoglycemia (HP:0001998)2.09707735
105Complement deficiency (HP:0004431)2.09488437
106Pachygyria (HP:0001302)2.09083111
107Syncope (HP:0001279)2.08613431
108Pallor (HP:0000980)2.08452281
109Abnormality of glycine metabolism (HP:0010895)2.08242169
110Abnormality of serine family amino acid metabolism (HP:0010894)2.08242169
111Increased serum lactate (HP:0002151)2.06963695
112Failure to thrive in infancy (HP:0001531)2.05999326
113Optic disc pallor (HP:0000543)2.04932593
114Sclerocornea (HP:0000647)2.04128543
115Dilated cardiomyopathy (HP:0001644)2.02248713
116Partial agenesis of the corpus callosum (HP:0001338)2.01573710
117Aplasia/Hypoplasia of the brainstem (HP:0007362)2.01548347
118Hypoplasia of the brainstem (HP:0002365)2.01548347
119Progressive microcephaly (HP:0000253)2.01380153
120Abnormality of the fovea (HP:0000493)2.00443673
121Amblyopia (HP:0000646)1.98908717
122Nemaline bodies (HP:0003798)1.98424126
123Hyperglycinemia (HP:0002154)1.97699894
124Insidious onset (HP:0003587)1.97269913
125Termporal pattern (HP:0011008)1.97269913
126Epidermoid cyst (HP:0200040)1.97059017
127Abnormality of the renal medulla (HP:0100957)1.96847418
128Acute encephalopathy (HP:0006846)1.96826211
129Hepatic necrosis (HP:0002605)1.95609950
130Pancreatic islet-cell hyperplasia (HP:0004510)1.92777531
131Central scotoma (HP:0000603)1.92393888
132Asymmetric septal hypertrophy (HP:0001670)1.92350587
133Increased intramyocellular lipid droplets (HP:0012240)1.91138498
1343-Methylglutaconic aciduria (HP:0003535)1.90389768
135Poor coordination (HP:0002370)1.89440023
136Lipid accumulation in hepatocytes (HP:0006561)1.89013212
137Aplasia/Hypoplasia of the uvula (HP:0010293)1.87902749
138Conjunctival hamartoma (HP:0100780)1.86262202
139Progressive cerebellar ataxia (HP:0002073)1.86111270
140Cortical dysplasia (HP:0002539)1.86082315
141Anencephaly (HP:0002323)1.85167762
142Type 1 muscle fiber predominance (HP:0003803)1.84585707
143Abnormal mitochondria in muscle tissue (HP:0008316)1.84520841
144Abnormality of aspartate family amino acid metabolism (HP:0010899)1.84046798
145Aganglionic megacolon (HP:0002251)1.83395726
146Rimmed vacuoles (HP:0003805)1.81303153
147Ventricular arrhythmia (HP:0004308)1.80600325
148Hepatocellular necrosis (HP:0001404)1.80318205
149Lactic acidosis (HP:0003128)1.80069552
150Methylmalonic aciduria (HP:0012120)1.79816527
151Increased hepatocellular lipid droplets (HP:0006565)1.79693810
152Depression (HP:0000716)1.79687888
153Postaxial foot polydactyly (HP:0001830)1.79336502
154Right ventricular cardiomyopathy (HP:0011663)1.78919481
155Iris hypopigmentation (HP:0007730)1.78062246
156Abnormality of alanine metabolism (HP:0010916)1.77873605
157Hyperalaninemia (HP:0003348)1.77873605
158Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.77873605
159Spastic gait (HP:0002064)1.76546276
160Abnormality of methionine metabolism (HP:0010901)1.76140742
161Myokymia (HP:0002411)1.73887576
162Astigmatism (HP:0000483)1.73189579
163Increased muscle lipid content (HP:0009058)1.73185740
164Genital tract atresia (HP:0001827)1.69877010
165Preaxial hand polydactyly (HP:0001177)1.69304558
166Optic nerve coloboma (HP:0000588)1.69140796
167Vaginal atresia (HP:0000148)1.69101618
168Specific learning disability (HP:0001328)1.67642250
169Polymicrogyria (HP:0002126)1.66641528
170Aplasia/Hypoplasia of the macula (HP:0008059)1.64916721
171Renal Fanconi syndrome (HP:0001994)1.62834695
172Emotional lability (HP:0000712)1.62539625
173Tubulointerstitial nephritis (HP:0001970)1.62217065
174Methylmalonic acidemia (HP:0002912)1.61840945
175Agitation (HP:0000713)1.60191048
176Abnormality of DNA repair (HP:0003254)1.59465011
177Broad-based gait (HP:0002136)1.59390947
178Colon cancer (HP:0003003)1.58969030
179Prominent nasal bridge (HP:0000426)1.57342234
180Meckel diverticulum (HP:0002245)1.56318514
181CNS hypomyelination (HP:0003429)1.55377543

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PHKG14.35876141
2PHKG24.35876141
3OBSCN3.33096407
4MARK13.23833858
5TTN3.20435427
6PKN22.81994978
7TAOK32.70488481
8BCKDK2.60329424
9MAP4K22.38467773
10NEK12.14684172
11EPHA42.11935648
12LMTK21.97646504
13WNK31.93581622
14MAP3K41.90704802
15MAP2K41.87052234
16BMPR1B1.81610613
17DYRK31.77874766
18ZAK1.76372188
19CDK191.76251265
20MAP3K111.75842133
21EIF2AK11.72072519
22MAP3K101.70421578
23BCR1.65712288
24MAP3K71.64488217
25MAPK121.63207421
26PKN11.62802497
27MYLK1.58452928
28TLK11.57908116
29TRIM281.56853478
30TRIB31.53020204
31SRPK11.51380083
32ADRBK21.43099099
33INSRR1.42213631
34PINK11.41068810
35PDK21.38398402
36WEE11.38267376
37TESK21.37604976
38DAPK21.36326064
39CASK1.35321547
40CSNK1A1L1.32500342
41PDK31.31417690
42PDK41.31417690
43MAPK131.29999368
44PIK3CA1.29703952
45SIK11.26131759
46CAMK2D1.17931753
47CCNB11.14607002
48DMPK1.13751757
49FRK1.12587512
50KSR11.08633741
51NEK21.07035596
52CAMK2B1.05680932
53CDC71.05095007
54MINK11.03825659
55SGK4941.03190458
56SGK2231.03190458
57STK391.02600623
58PLK41.00953463
59PAK61.00070555
60GRK70.99840513
61MAPK110.99395490
62GRK60.98709621
63ATR0.98256481
64NUAK10.97780290
65WNK40.96515757
66MARK30.95844993
67PRKAA10.94829796
68MAP2K70.94125242
69CSNK1G10.93519863
70VRK20.93465091
71TNK20.92336840
72NTRK30.92227116
73DYRK20.91938023
74PAK30.91835312
75CAMK2A0.91762350
76OXSR10.90877374
77CAMK2G0.90754567
78TNIK0.89311175
79GRK10.88228662
80RAF10.86573427
81STK160.86159604
82PLK10.85761795
83VRK10.85245978
84STK240.85039469
85CDK50.82573137
86NME10.81354238
87RPS6KA50.79785503
88CLK10.78074437
89TXK0.75848535
90SIK20.75667379
91MAP4K10.75337457
92RIPK10.74763958
93CSNK1G20.73868836
94PRKAA20.73455813
95BRSK10.72838589
96CHEK20.72806957
97PRKD10.72127611
98ICK0.71530766
99SGK30.69620142
100UHMK10.68473804
101PRPF4B0.67390037
102AURKA0.66555576
103PRKACG0.64436086
104CAMK40.63067306
105SGK20.62525557
106FGFR20.61640498
107FLT30.61245766
108EPHA30.60546629
109PLK30.60372942
110RET0.60267833
111PRKACB0.59902118
112DYRK1A0.59289800
113EPHB10.58934597
114NTRK20.58748026
115MAP3K120.58490198
116PIM20.58344310
117MUSK0.57062107
118CSNK1G30.56878811
119DAPK30.56019185
120PRKCZ0.55722900
121SGK10.55660289
122LIMK10.55646107
123ADRBK10.55571372
124KSR20.55484368
125GRK50.55339205
126ROCK20.54800168
127MARK20.54515204
128PIM10.54408417
129SYK0.53503673
130ERBB30.53364474
131ATM0.52265467
132STK40.52032053
133STK110.51483135
134FGR0.51351421
135DYRK1B0.51242182
136RPS6KA40.51035639
137EPHB20.49632738
138ROCK10.49579618
139MAPK150.49268044
140PRKCQ0.48925357
141PRKACA0.48712572
142EEF2K0.48310115
143PRKG10.47768524
144CDK150.47223311
145PDPK10.47097119
146ERBB20.47064322
147PLK20.46890652
148MAPK40.46504833
149CDK180.45661151
150MAP3K60.45513599
151FYN0.45345524
152CDK140.44721025
153PRKCG0.44298731
154MAP2K10.43875929
155RPS6KA30.43590933
156ILK0.43522054
157MATK0.43502345
158BTK0.42365491
159KDR0.42062702
160CSNK2A10.40207510
161PTK2B0.39708933
162SIK30.39701414
163CDK20.39022490
164CDK10.38308669
165CSNK1A10.37352747
166CAMKK20.37131188

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.69488173
2Homologous recombination_Homo sapiens_hsa034403.45390803
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.18509065
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.00311245
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.85121875
6Fanconi anemia pathway_Homo sapiens_hsa034602.84103782
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.82112318
8Propanoate metabolism_Homo sapiens_hsa006402.62238435
9Base excision repair_Homo sapiens_hsa034102.58857976
10Butanoate metabolism_Homo sapiens_hsa006502.57288521
11Fatty acid degradation_Homo sapiens_hsa000712.57252642
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.54167229
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.46178238
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.41251385
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.40965227
16Arginine biosynthesis_Homo sapiens_hsa002202.30850769
17RNA polymerase_Homo sapiens_hsa030202.18103859
18Mismatch repair_Homo sapiens_hsa034302.13354408
19Fatty acid metabolism_Homo sapiens_hsa012122.13252634
20Ribosome_Homo sapiens_hsa030102.11004332
21Pyruvate metabolism_Homo sapiens_hsa006202.01182943
22Nitrogen metabolism_Homo sapiens_hsa009101.96626037
23Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.95853057
24Tryptophan metabolism_Homo sapiens_hsa003801.90963071
25DNA replication_Homo sapiens_hsa030301.86140158
26Fatty acid elongation_Homo sapiens_hsa000621.84679357
27Carbon metabolism_Homo sapiens_hsa012001.82030937
28Protein export_Homo sapiens_hsa030601.79935457
29Basal transcription factors_Homo sapiens_hsa030221.76593783
30Proteasome_Homo sapiens_hsa030501.74074801
31Non-homologous end-joining_Homo sapiens_hsa034501.73033248
32Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.71289993
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.65445709
34Cardiac muscle contraction_Homo sapiens_hsa042601.62850222
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.60993527
36Collecting duct acid secretion_Homo sapiens_hsa049661.58650302
37Nucleotide excision repair_Homo sapiens_hsa034201.50965084
38Spliceosome_Homo sapiens_hsa030401.48967929
39Regulation of autophagy_Homo sapiens_hsa041401.48467222
40Peroxisome_Homo sapiens_hsa041461.44015685
41Biosynthesis of amino acids_Homo sapiens_hsa012301.43641195
42PPAR signaling pathway_Homo sapiens_hsa033201.40237063
43Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.37962850
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.37495173
45Complement and coagulation cascades_Homo sapiens_hsa046101.37079543
46beta-Alanine metabolism_Homo sapiens_hsa004101.32508047
47RNA degradation_Homo sapiens_hsa030181.29707855
48Sulfur relay system_Homo sapiens_hsa041221.29321904
49Pyrimidine metabolism_Homo sapiens_hsa002401.27250970
50Olfactory transduction_Homo sapiens_hsa047401.24668521
51Dilated cardiomyopathy_Homo sapiens_hsa054141.18903285
52RNA transport_Homo sapiens_hsa030131.18440770
53Bile secretion_Homo sapiens_hsa049761.16940320
54Starch and sucrose metabolism_Homo sapiens_hsa005001.15877778
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.13054081
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.12953230
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.12843691
58alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.12475379
59Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.12087544
60Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.11293373
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.10386213
62Parkinsons disease_Homo sapiens_hsa050121.09631686
63Lysine degradation_Homo sapiens_hsa003101.06611144
64Oxidative phosphorylation_Homo sapiens_hsa001901.04004933
65Phenylalanine metabolism_Homo sapiens_hsa003601.02762665
66ABC transporters_Homo sapiens_hsa020100.99576387
67Alzheimers disease_Homo sapiens_hsa050100.98008288
68Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.97234779
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.96724981
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.95730833
71Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.93017836
72Linoleic acid metabolism_Homo sapiens_hsa005910.92891322
73Ether lipid metabolism_Homo sapiens_hsa005650.89580226
74Purine metabolism_Homo sapiens_hsa002300.89025287
75Tyrosine metabolism_Homo sapiens_hsa003500.88034095
76Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.87823595
77Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.87093760
78Histidine metabolism_Homo sapiens_hsa003400.84807846
79Cysteine and methionine metabolism_Homo sapiens_hsa002700.82494028
80GABAergic synapse_Homo sapiens_hsa047270.82450114
81Fructose and mannose metabolism_Homo sapiens_hsa000510.82339849
82One carbon pool by folate_Homo sapiens_hsa006700.81017767
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.79873477
84Cyanoamino acid metabolism_Homo sapiens_hsa004600.79050585
85Arginine and proline metabolism_Homo sapiens_hsa003300.77801939
86Glucagon signaling pathway_Homo sapiens_hsa049220.77075571
87Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.76413117
88Chemical carcinogenesis_Homo sapiens_hsa052040.76214382
89Vitamin B6 metabolism_Homo sapiens_hsa007500.75259123
90Cell cycle_Homo sapiens_hsa041100.74482223
91Steroid hormone biosynthesis_Homo sapiens_hsa001400.74412542
92Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.72896701
93Fat digestion and absorption_Homo sapiens_hsa049750.71886910
94Taste transduction_Homo sapiens_hsa047420.70754931
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.70505563
96Circadian entrainment_Homo sapiens_hsa047130.70394394
97Nicotine addiction_Homo sapiens_hsa050330.70002527
98Retinol metabolism_Homo sapiens_hsa008300.69614142
99Primary immunodeficiency_Homo sapiens_hsa053400.69436335
100SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69373359
101Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.69361128
102Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.68877849
103mRNA surveillance pathway_Homo sapiens_hsa030150.68350781
104Caffeine metabolism_Homo sapiens_hsa002320.65131438
105Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64917632
106Steroid biosynthesis_Homo sapiens_hsa001000.63335789
107Renin secretion_Homo sapiens_hsa049240.62249604
108AMPK signaling pathway_Homo sapiens_hsa041520.62041027
109Sulfur metabolism_Homo sapiens_hsa009200.61918601
110Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61316296
111Insulin resistance_Homo sapiens_hsa049310.60545988
112Glutamatergic synapse_Homo sapiens_hsa047240.58506743
113Insulin signaling pathway_Homo sapiens_hsa049100.55380686
114Selenocompound metabolism_Homo sapiens_hsa004500.54775771
115Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.54384808
116Oxytocin signaling pathway_Homo sapiens_hsa049210.53698926
117Calcium signaling pathway_Homo sapiens_hsa040200.49417065
118Long-term potentiation_Homo sapiens_hsa047200.49098006
119Morphine addiction_Homo sapiens_hsa050320.49016784
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.46991950
121Glycerophospholipid metabolism_Homo sapiens_hsa005640.46776985
122Staphylococcus aureus infection_Homo sapiens_hsa051500.46536718
123cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45965252
124Salivary secretion_Homo sapiens_hsa049700.45535834
125Oocyte meiosis_Homo sapiens_hsa041140.44663625
126Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44320354
127Gastric acid secretion_Homo sapiens_hsa049710.44009145
128Dopaminergic synapse_Homo sapiens_hsa047280.43797234
129Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.42548587
130Drug metabolism - other enzymes_Homo sapiens_hsa009830.42520061
131Glycerolipid metabolism_Homo sapiens_hsa005610.42474202
132Cholinergic synapse_Homo sapiens_hsa047250.42085295
133Fatty acid biosynthesis_Homo sapiens_hsa000610.41808065
134Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40238699
135Synaptic vesicle cycle_Homo sapiens_hsa047210.39893926
136Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39822890
137Systemic lupus erythematosus_Homo sapiens_hsa053220.39476561
138Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39300212
139Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38350014
140Huntingtons disease_Homo sapiens_hsa050160.37176425
141Type II diabetes mellitus_Homo sapiens_hsa049300.37170316
142Alcoholism_Homo sapiens_hsa050340.35726718
143Axon guidance_Homo sapiens_hsa043600.35158626
144Metabolic pathways_Homo sapiens_hsa011000.32897726
145Gap junction_Homo sapiens_hsa045400.32519360
146Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.32414059
147Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32291243
148Aldosterone synthesis and secretion_Homo sapiens_hsa049250.31777132
149Phototransduction_Homo sapiens_hsa047440.31026453
150Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.28058973
151Cocaine addiction_Homo sapiens_hsa050300.27348886
152Glutathione metabolism_Homo sapiens_hsa004800.23703366
153Epstein-Barr virus infection_Homo sapiens_hsa051690.22266005
154Transcriptional misregulation in cancer_Homo sapiens_hsa052020.21885207
155Maturity onset diabetes of the young_Homo sapiens_hsa049500.21771644

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »