NARFL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.53491072
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.21602585
3NADH metabolic process (GO:0006734)4.94131606
4L-fucose catabolic process (GO:0042355)4.88844163
5fucose catabolic process (GO:0019317)4.88844163
6L-fucose metabolic process (GO:0042354)4.88844163
7mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.69926909
8ATP synthesis coupled proton transport (GO:0015986)4.62866313
9energy coupled proton transport, down electrochemical gradient (GO:0015985)4.62866313
10proteasome assembly (GO:0043248)4.47896774
11protein import into peroxisome matrix (GO:0016558)4.39323648
12regulation of skeletal muscle contraction (GO:0014819)4.36094311
13respiratory electron transport chain (GO:0022904)4.31393411
14purine nucleobase biosynthetic process (GO:0009113)4.29547814
15preassembly of GPI anchor in ER membrane (GO:0016254)4.25849895
16electron transport chain (GO:0022900)4.20507377
17termination of RNA polymerase III transcription (GO:0006386)4.16601861
18transcription elongation from RNA polymerase III promoter (GO:0006385)4.16601861
19tricarboxylic acid cycle (GO:0006099)4.11952992
20tRNA modification (GO:0006400)4.06795198
21phosphatidylglycerol biosynthetic process (GO:0006655)4.06420670
22regulation of mitochondrial translation (GO:0070129)4.05693073
23ubiquinone biosynthetic process (GO:0006744)4.04938514
24quinone biosynthetic process (GO:1901663)4.04938514
25DNA deamination (GO:0045006)4.03653783
26nucleobase biosynthetic process (GO:0046112)4.01635421
27autophagic vacuole fusion (GO:0000046)3.99984125
28cellular response to ATP (GO:0071318)3.98179774
29oxidative phosphorylation (GO:0006119)3.93296781
30chaperone-mediated protein transport (GO:0072321)3.79799655
31purinergic nucleotide receptor signaling pathway (GO:0035590)3.75062913
32protein complex biogenesis (GO:0070271)3.72394007
33maturation of SSU-rRNA (GO:0030490)3.71973907
34rRNA modification (GO:0000154)3.71696563
35mitochondrial respiratory chain complex assembly (GO:0033108)3.68761501
36ubiquinone metabolic process (GO:0006743)3.61097117
37nucleoside transmembrane transport (GO:1901642)3.59763184
38mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.59742947
39mitochondrial respiratory chain complex I assembly (GO:0032981)3.59742947
40NADH dehydrogenase complex assembly (GO:0010257)3.59742947
41negative regulation of cell aging (GO:0090344)3.57585611
42* metallo-sulfur cluster assembly (GO:0031163)3.51200769
43* iron-sulfur cluster assembly (GO:0016226)3.51200769
44guanosine-containing compound biosynthetic process (GO:1901070)3.49735144
45meiotic chromosome segregation (GO:0045132)3.48425759
46regulation of cellular amino acid metabolic process (GO:0006521)3.45588932
47L-methionine salvage (GO:0071267)3.44055400
48L-methionine biosynthetic process (GO:0071265)3.44055400
49amino acid salvage (GO:0043102)3.44055400
50inner mitochondrial membrane organization (GO:0007007)3.41563086
51fucosylation (GO:0036065)3.41554716
52glycine metabolic process (GO:0006544)3.39868575
53GMP metabolic process (GO:0046037)3.38328033
54GPI anchor biosynthetic process (GO:0006506)3.37209619
55negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.36462556
56branched-chain amino acid catabolic process (GO:0009083)3.34913201
57DNA strand renaturation (GO:0000733)3.33864822
58negative regulation of telomere maintenance (GO:0032205)3.32138955
59folic acid metabolic process (GO:0046655)3.31189551
607-methylguanosine mRNA capping (GO:0006370)3.30226379
61positive regulation of protein kinase C signaling (GO:0090037)3.29670858
62GPI anchor metabolic process (GO:0006505)3.28141894
63cardiolipin metabolic process (GO:0032048)3.27252341
64positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.23074187
65L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.21836086
66RNA capping (GO:0036260)3.19548850
677-methylguanosine RNA capping (GO:0009452)3.19548850
68synaptic transmission, cholinergic (GO:0007271)3.18675992
69protein targeting to mitochondrion (GO:0006626)3.16427996
70spliceosomal snRNP assembly (GO:0000387)3.15251554
71protein-cofactor linkage (GO:0018065)3.13879949
72cullin deneddylation (GO:0010388)3.13735184
73aggressive behavior (GO:0002118)3.10380290
74DNA strand elongation involved in DNA replication (GO:0006271)3.10268852
75establishment of protein localization to mitochondrial membrane (GO:0090151)3.09841729
76regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.07525523
77coenzyme A biosynthetic process (GO:0015937)3.06860636
78peptidyl-histidine modification (GO:0018202)3.05999386
79establishment of protein localization to mitochondrion (GO:0072655)3.05992648
80oxaloacetate metabolic process (GO:0006107)3.05412697
81anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.05065886
82protein deneddylation (GO:0000338)3.03212751
83negative regulation of ligase activity (GO:0051352)3.02980460
84negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.02980460
85positive regulation of prostaglandin secretion (GO:0032308)3.02873657
86L-serine metabolic process (GO:0006563)3.01582722
87serine family amino acid biosynthetic process (GO:0009070)3.00818039
88telomere maintenance via semi-conservative replication (GO:0032201)2.99616013
89DNA strand elongation (GO:0022616)2.99596367
90respiratory chain complex IV assembly (GO:0008535)2.99385914
91GTP biosynthetic process (GO:0006183)2.97168745
92cellular response to exogenous dsRNA (GO:0071360)2.96497563
93cellular component biogenesis (GO:0044085)2.94243705
94protein targeting to peroxisome (GO:0006625)2.94108583
95establishment of protein localization to peroxisome (GO:0072663)2.94108583
96protein localization to peroxisome (GO:0072662)2.94108583
97base-excision repair, AP site formation (GO:0006285)2.93562194
98peroxisomal transport (GO:0043574)2.92654288
99RNA modification (GO:0009451)2.92522146
100negative regulation of Ras GTPase activity (GO:0034261)2.91739755
101cellular ketone body metabolic process (GO:0046950)2.90592051
102water-soluble vitamin biosynthetic process (GO:0042364)2.90377252
103regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.90091553
104DNA replication checkpoint (GO:0000076)2.89776213
105ribosome biogenesis (GO:0042254)2.89397491
106DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.89181087
107ribosomal large subunit biogenesis (GO:0042273)2.88478191
108branched-chain amino acid metabolic process (GO:0009081)2.86929208
109rRNA methylation (GO:0031167)2.86639261
110C-terminal protein lipidation (GO:0006501)2.86609983
111antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.86436095
112organelle membrane fusion (GO:0090174)2.86208827
113regulation of synapse structural plasticity (GO:0051823)2.86171289
114cytochrome complex assembly (GO:0017004)2.85374899
115signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.85197471
116signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.85197471
117signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.85197471
118response to ATP (GO:0033198)2.85053779
119pseudouridine synthesis (GO:0001522)2.84859530
120signal transduction involved in DNA integrity checkpoint (GO:0072401)2.84081981
121signal transduction involved in DNA damage checkpoint (GO:0072422)2.84081981
122detection of light stimulus involved in visual perception (GO:0050908)2.83907692
123detection of light stimulus involved in sensory perception (GO:0050962)2.83907692
124intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.83405120
125signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.83405120
126positive regulation of fatty acid transport (GO:2000193)2.83375947
127GDP-mannose metabolic process (GO:0019673)2.82871795
128regulation of acyl-CoA biosynthetic process (GO:0050812)2.82633596
129protein localization to mitochondrion (GO:0070585)2.81830403
130positive regulation of triglyceride biosynthetic process (GO:0010867)2.81343110
131deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.81137126
132ribosomal small subunit assembly (GO:0000028)2.80272366
133ribonucleoprotein complex biogenesis (GO:0022613)2.79793119
134L-phenylalanine metabolic process (GO:0006558)2.79138378
135erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.79138378
136lysine catabolic process (GO:0006554)2.79117440
137lysine metabolic process (GO:0006553)2.79117440
138signal transduction involved in cell cycle checkpoint (GO:0072395)2.78597493
139purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.78083520
140galactose catabolic process (GO:0019388)2.77919632
141aspartate family amino acid catabolic process (GO:0009068)2.77861651
142purine nucleoside triphosphate biosynthetic process (GO:0009145)2.77833208
143mannosylation (GO:0097502)2.77554107
144regulation of action potential (GO:0098900)2.76839471
145proline metabolic process (GO:0006560)2.76340851
146positive regulation of organic acid transport (GO:0032892)2.75956989
147purinergic receptor signaling pathway (GO:0035587)2.75717545
148DNA replication initiation (GO:0006270)2.75455843
149translation (GO:0006412)2.75330494
150seminiferous tubule development (GO:0072520)2.73998319
151protein insertion into membrane (GO:0051205)2.73825063
152glycolipid biosynthetic process (GO:0009247)2.73487789
153pantothenate metabolic process (GO:0015939)2.72508812
154regulation of cytokine production involved in inflammatory response (GO:1900015)2.72242677
155grooming behavior (GO:0007625)2.69264668
156ribonucleoside bisphosphate biosynthetic process (GO:0034030)2.67614074
157nucleoside bisphosphate biosynthetic process (GO:0033866)2.67614074
158purine nucleoside bisphosphate biosynthetic process (GO:0034033)2.67614074
159protein prenylation (GO:0018342)2.67566196
160prenylation (GO:0097354)2.67566196
161response to misfolded protein (GO:0051788)2.67533682
162positive regulation of icosanoid secretion (GO:0032305)2.65478979
163positive regulation of amino acid transport (GO:0051957)2.65240717
164positive regulation of defense response to virus by host (GO:0002230)2.65118482
165NAD biosynthetic process (GO:0009435)2.61603966
166neuromuscular synaptic transmission (GO:0007274)2.61516090
167RNA methylation (GO:0001510)2.59246467
168sialylation (GO:0097503)2.57793411
169positive regulation of mitochondrial fission (GO:0090141)2.57615147
170tRNA processing (GO:0008033)2.56086824
171neuronal action potential (GO:0019228)2.53721220
172ketone body metabolic process (GO:1902224)2.52863998
173regulation of nuclear cell cycle DNA replication (GO:0033262)2.52827339
174histone H3-K9 methylation (GO:0051567)2.51198612
175regulation of feeding behavior (GO:0060259)2.50315193
176C-terminal protein amino acid modification (GO:0018410)2.50233797
177eosinophil chemotaxis (GO:0048245)2.50166361
178sensory perception of taste (GO:0050909)2.50035411
179neurotransmitter catabolic process (GO:0042135)2.49276827
180regulation of mitochondrial fission (GO:0090140)2.48976863
181mitochondrial RNA metabolic process (GO:0000959)2.48931341
182negative regulation of reactive oxygen species metabolic process (GO:2000378)2.46043305
183cornea development in camera-type eye (GO:0061303)2.43360626

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.64739488
2* JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.33683858
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.08626252
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.76650918
5* ETS1_20019798_ChIP-Seq_JURKAT_Human3.67405303
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.51079941
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.40411870
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.40105865
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.37631815
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.17862041
11MYC_18358816_ChIP-ChIP_MESCs_Mouse3.03961772
12VDR_21846776_ChIP-Seq_THP-1_Human3.03535834
13* E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.98722774
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.96270519
15THAP11_20581084_ChIP-Seq_MESCs_Mouse2.70875797
16* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.61942021
17* P68_20966046_ChIP-Seq_HELA_Human2.59690158
18SRF_21415370_ChIP-Seq_HL-1_Mouse2.59515657
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.53259380
20LXR_22292898_ChIP-Seq_THP-1_Human2.44980332
21YY1_21170310_ChIP-Seq_MESCs_Mouse2.42225265
22MYC_19030024_ChIP-ChIP_MESCs_Mouse2.40620894
23PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.40223791
24PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.36899667
25DCP1A_22483619_ChIP-Seq_HELA_Human2.32666662
26TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.31252459
27MYC_19079543_ChIP-ChIP_MESCs_Mouse2.28594267
28E2F1_18555785_ChIP-Seq_MESCs_Mouse2.23559747
29* VDR_23849224_ChIP-Seq_CD4+_Human2.22082296
30SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.21508056
31* E2F1_20622854_ChIP-Seq_HELA_Human2.20934804
32ELF1_20517297_ChIP-Seq_JURKAT_Human2.17593220
33FOXP3_21729870_ChIP-Seq_TREG_Human2.12051934
34XRN2_22483619_ChIP-Seq_HELA_Human2.11348414
35NOTCH1_21737748_ChIP-Seq_TLL_Human2.08714876
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.07488666
37* GABP_19822575_ChIP-Seq_HepG2_Human2.07398406
38E2F7_22180533_ChIP-Seq_HELA_Human2.03197315
39ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.00097847
40IKZF1_21737484_ChIP-ChIP_HCT116_Human1.99870043
41CTCF_27219007_Chip-Seq_Bcells_Human1.89823743
42SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.87192742
43CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.82506878
44ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.81229969
45ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.80730585
46CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.79201884
47* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.74861283
48E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.73567292
49MAF_26560356_Chip-Seq_TH2_Human1.73554438
50NELFA_20434984_ChIP-Seq_ESCs_Mouse1.67400164
51SA1_27219007_Chip-Seq_ERYTHROID_Human1.65884602
52* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.65009245
53* ERA_21632823_ChIP-Seq_H3396_Human1.63376331
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.63033095
55BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.62785595
56ERG_21242973_ChIP-ChIP_JURKAT_Human1.62324215
57* SMC4_20622854_ChIP-Seq_HELA_Human1.60329553
58CTCF_20526341_ChIP-Seq_ESCs_Human1.58684967
59EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57258775
60RARB_24833708_ChIP-Seq_LIVER_Mouse1.56094482
61POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.56088524
62ZNF274_21170338_ChIP-Seq_K562_Hela1.56055577
63STAT6_21828071_ChIP-Seq_BEAS2B_Human1.55639589
64TTF2_22483619_ChIP-Seq_HELA_Human1.55586218
65CIITA_25753668_ChIP-Seq_RAJI_Human1.55435822
66MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.55287989
67MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.54584541
68* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53735599
69DNAJC2_21179169_ChIP-ChIP_NT2_Human1.49532189
70CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.47707651
71SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.46095707
72SA1_27219007_Chip-Seq_Bcells_Human1.45665042
73NANOG_18555785_ChIP-Seq_MESCs_Mouse1.45407904
74* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.44543659
75* CTCF_21964334_Chip-Seq_Bcells_Human1.44333544
76SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.43647647
77P300_27268052_Chip-Seq_Bcells_Human1.42336062
78MYC_22102868_ChIP-Seq_BL_Human1.39889234
79* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.38687312
80OCT4_20526341_ChIP-Seq_ESCs_Human1.37944724
81* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.37358929
82* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36908348
83* PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.36695498
84IRF8_22096565_ChIP-ChIP_GC-B_Human1.36500434
85RARA_24833708_ChIP-Seq_LIVER_Mouse1.35706545
86CTCF_27219007_Chip-Seq_ERYTHROID_Human1.35481903
87ZFX_18555785_ChIP-Seq_MESCs_Mouse1.35071154
88YY1_22570637_ChIP-Seq_MALME-3M_Human1.34652719
89STAT3_1855785_ChIP-Seq_MESCs_Mouse1.34577602
90TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.34259163
91GATA1_22025678_ChIP-Seq_K562_Human1.34117711
92HOXB4_20404135_ChIP-ChIP_EML_Mouse1.33063005
93FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.30931937
94OCT4_19829295_ChIP-Seq_ESCs_Human1.30393523
95E2F4_17652178_ChIP-ChIP_JURKAT_Human1.30385393
96RXRA_24833708_ChIP-Seq_LIVER_Mouse1.28781138
97LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.28571993
98CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.28365293
99CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.27096708
100MYCN_18555785_ChIP-Seq_MESCs_Mouse1.26702096
101* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.26301442
102EZH2_22144423_ChIP-Seq_EOC_Human1.25975940
103VDR_24763502_ChIP-Seq_THP-1_Human1.25416173
104TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.23839940
105RAC3_21632823_ChIP-Seq_H3396_Human1.23605698
106HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.22340955
107* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.22335662
108MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.22068590
109PU.1_20513432_ChIP-Seq_Bcells_Mouse1.21333773
110TAF2_19829295_ChIP-Seq_ESCs_Human1.20489184
111RACK7_27058665_Chip-Seq_MCF-7_Human1.19210227
112PPARA_22158963_ChIP-Seq_LIVER_Mouse1.18877004
113P53_21459846_ChIP-Seq_SAOS-2_Human1.18737511
114ZNF263_19887448_ChIP-Seq_K562_Human1.17803297
115REST_18959480_ChIP-ChIP_MESCs_Mouse1.17474340
116MAF_26560356_Chip-Seq_TH1_Human1.17015586
117MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.16537061
118TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.15877249
119EZH2_27294783_Chip-Seq_ESCs_Mouse1.15458087
120KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.15169109
121KDM2B_26808549_Chip-Seq_SUP-B15_Human1.14292114
122ETS1_21867929_ChIP-Seq_TH2_Mouse1.14137730
123* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.13881548
124TP63_22573176_ChIP-Seq_HFKS_Human1.12273403
125SUZ12_27294783_Chip-Seq_ESCs_Mouse1.11196998
126GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.10658550
127KDM2B_26808549_Chip-Seq_DND41_Human1.09798592
128EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.08791756
129ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.08435466
130* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08134833
131NANOG_20526341_ChIP-Seq_ESCs_Human1.08034169
132KDM5A_27292631_Chip-Seq_BREAST_Human1.07977325
133EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.05975586
134TBX5_21415370_ChIP-Seq_HL-1_Mouse1.04055457
135CREB1_26743006_Chip-Seq_LNCaP_Human1.03869487
136ELK1_19687146_ChIP-ChIP_HELA_Human1.02584451
137RXR_22158963_ChIP-Seq_LIVER_Mouse1.01643252
138TET1_21451524_ChIP-Seq_MESCs_Mouse1.01400912
139CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.01376330
140MYC_18940864_ChIP-ChIP_HL60_Human1.01156284
141POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.00351788
142SRY_22984422_ChIP-ChIP_TESTIS_Rat0.98833160
143SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.98409847
144BCL6_27268052_Chip-Seq_Bcells_Human0.97938525
145EGR1_23403033_ChIP-Seq_LIVER_Mouse0.95518575
146MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.92187737
147ELK1_22589737_ChIP-Seq_MCF10A_Human0.91629057
148BCOR_27268052_Chip-Seq_Bcells_Human0.91259273
149* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.90423438
150E2F1_21310950_ChIP-Seq_MCF-7_Human0.89989498
151* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.89267476
152DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.89170237
153ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.88052136
154CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.87463797
155FOXP1_21924763_ChIP-Seq_HESCs_Human0.86688738
156* PHF8_20622854_ChIP-Seq_HELA_Human0.86678272
157CTCF_26484167_Chip-Seq_Bcells_Mouse0.86296456
158SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.83209361
159STAT1_20625510_ChIP-Seq_HELA_Human0.82545002
160RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.82336949
161TFEB_21752829_ChIP-Seq_HELA_Human0.81960806
162HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.81263447
163RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.80608675

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005423_abnormal_somatic_nervous4.46509299
2MP0009840_abnormal_foam_cell4.26289896
3MP0002837_dystrophic_cardiac_calcinosis4.14832741
4MP0006036_abnormal_mitochondrial_physio3.37231411
5MP0001968_abnormal_touch/_nociception3.35053797
6MP0005171_absent_coat_pigmentation3.10111028
7MP0003806_abnormal_nucleotide_metabolis2.98669250
8MP0003136_yellow_coat_color2.96902345
9MP0003693_abnormal_embryo_hatching2.86039180
10MP0002653_abnormal_ependyma_morphology2.68209949
11MP0005174_abnormal_tail_pigmentation2.61544243
12MP0006035_abnormal_mitochondrial_morpho2.59517517
13MP0005332_abnormal_amino_acid2.53898107
14MP0003303_peritoneal_inflammation2.51776268
15MP0000566_synostosis2.45759714
16MP0002736_abnormal_nociception_after2.43824306
17MP0004084_abnormal_cardiac_muscle2.39581853
18MP0000749_muscle_degeneration2.36505946
19MP0009278_abnormal_bone_marrow2.33541839
20MP0005360_urolithiasis2.29139957
21MP0008260_abnormal_autophagy2.26551907
22MP0005365_abnormal_bile_salt2.23750025
23MP0003186_abnormal_redox_activity2.21676054
24MP0003646_muscle_fatigue2.16454183
25MP0008875_abnormal_xenobiotic_pharmacok2.16324089
26MP0000751_myopathy2.13039739
27MP0001764_abnormal_homeostasis2.11004105
28MP0003656_abnormal_erythrocyte_physiolo2.06860816
29MP0004036_abnormal_muscle_relaxation2.05370555
30MP0001188_hyperpigmentation2.01379086
31MP0002139_abnormal_hepatobiliary_system1.97783439
32MP0005330_cardiomyopathy1.96057556
33MP0002269_muscular_atrophy1.84042430
34MP0005645_abnormal_hypothalamus_physiol1.83844409
35MP0004215_abnormal_myocardial_fiber1.76590008
36MP0004043_abnormal_pH_regulation1.72022527
37MP0005075_abnormal_melanosome_morpholog1.70644013
38MP0001664_abnormal_digestion1.68704970
39MP0004957_abnormal_blastocyst_morpholog1.67503992
40MP0003718_maternal_effect1.64532953
41MP0005670_abnormal_white_adipose1.63942305
42MP0003111_abnormal_nucleus_morphology1.63050918
43MP0003880_abnormal_central_pattern1.62977200
44MP0005551_abnormal_eye_electrophysiolog1.61700929
45MP0005058_abnormal_lysosome_morphology1.58735543
46MP0001873_stomach_inflammation1.58356727
47MP0005085_abnormal_gallbladder_physiolo1.58221997
48MP0005451_abnormal_body_composition1.54397007
49MP0002735_abnormal_chemical_nociception1.52544321
50MP0009745_abnormal_behavioral_response1.52290311
51MP0003221_abnormal_cardiomyocyte_apopto1.51127970
52MP0001502_abnormal_circadian_rhythm1.50247798
53MP0004145_abnormal_muscle_electrophysio1.49677678
54MP0000747_muscle_weakness1.47940090
55MP0004142_abnormal_muscle_tone1.46325292
56MP0000358_abnormal_cell_content/1.45933429
57MP0004019_abnormal_vitamin_homeostasis1.44862045
58MP0002876_abnormal_thyroid_physiology1.44586304
59MP0003137_abnormal_impulse_conducting1.44535828
60MP0009643_abnormal_urine_homeostasis1.43238489
61MP0004381_abnormal_hair_follicle1.41595901
62MP0008932_abnormal_embryonic_tissue1.41477161
63MP0002132_abnormal_respiratory_system1.41207253
64MP0003195_calcinosis1.41011022
65MP0002064_seizures1.38761488
66MP0004147_increased_porphyrin_level1.38442630
67MP0005319_abnormal_enzyme/_coenzyme1.37351984
68MP0008058_abnormal_DNA_repair1.36666315
69MP0001970_abnormal_pain_threshold1.36159139
70MP0000538_abnormal_urinary_bladder1.33975440
71MP0000750_abnormal_muscle_regeneration1.31383192
72MP0000015_abnormal_ear_pigmentation1.31379070
73MP0005636_abnormal_mineral_homeostasis1.31207314
74MP0001756_abnormal_urination1.27632144
75MP0010329_abnormal_lipoprotein_level1.27047775
76MP0001919_abnormal_reproductive_system1.26013151
77MP0003878_abnormal_ear_physiology1.25117418
78MP0005377_hearing/vestibular/ear_phenot1.25117418
79MP0001486_abnormal_startle_reflex1.22410512
80MP0002572_abnormal_emotion/affect_behav1.20572143
81MP0010094_abnormal_chromosome_stability1.19968545
82MP0008872_abnormal_physiological_respon1.19883492
83MP0001905_abnormal_dopamine_level1.16670355
84MP0005646_abnormal_pituitary_gland1.16058019
85MP0001663_abnormal_digestive_system1.14392635
86MP0003635_abnormal_synaptic_transmissio1.14313624
87MP0001529_abnormal_vocalization1.13784560
88MP0008995_early_reproductive_senescence1.13314221
89MP0002972_abnormal_cardiac_muscle1.13176340
90MP0002272_abnormal_nervous_system1.11878515
91MP0001986_abnormal_taste_sensitivity1.11772079
92MP0005266_abnormal_metabolism1.11481834
93MP0002638_abnormal_pupillary_reflex1.10444878
94MP0005584_abnormal_enzyme/coenzyme_acti1.10404359
95MP0002102_abnormal_ear_morphology1.10367170
96MP0002063_abnormal_learning/memory/cond1.09440608
97MP0005083_abnormal_biliary_tract1.09245977
98MP0005620_abnormal_muscle_contractility1.09101011
99MP0001545_abnormal_hematopoietic_system1.08291813
100MP0005397_hematopoietic_system_phenotyp1.08291813
101MP0003077_abnormal_cell_cycle1.06921175
102MP0004133_heterotaxia1.05319268
103MP0006082_CNS_inflammation1.05277191
104MP0002733_abnormal_thermal_nociception1.05273208
105MP0005084_abnormal_gallbladder_morpholo1.03928787
106MP0004859_abnormal_synaptic_plasticity1.01348558
107MP0000026_abnormal_inner_ear0.98970339
108MP0003786_premature_aging0.95498315
109MP0008057_abnormal_DNA_replication0.95122866
110MP0002118_abnormal_lipid_homeostasis0.94186136
111MP0000609_abnormal_liver_physiology0.90616916
112MP0002106_abnormal_muscle_physiology0.90202293
113MP0010386_abnormal_urinary_bladder0.89393934
114MP0004130_abnormal_muscle_cell0.88968855
115MP0005379_endocrine/exocrine_gland_phen0.86090154
116MP0009697_abnormal_copulation0.84910336
117MP0002751_abnormal_autonomic_nervous0.84329633
118MP0009333_abnormal_splenocyte_physiolog0.83937390
119MP0005385_cardiovascular_system_phenoty0.83818153
120MP0001544_abnormal_cardiovascular_syste0.83818153
121MP0005253_abnormal_eye_physiology0.83775941
122MP0002078_abnormal_glucose_homeostasis0.82228378
123MP0005671_abnormal_response_to0.81933176
124MP0005376_homeostasis/metabolism_phenot0.79592739
125MP0001963_abnormal_hearing_physiology0.79530465
126MP0006276_abnormal_autonomic_nervous0.78612430
127MP0005389_reproductive_system_phenotype0.77812773
128MP0005381_digestive/alimentary_phenotyp0.77756448
129MP0009046_muscle_twitch0.77656903
130MP0002557_abnormal_social/conspecific_i0.77077888
131MP0002160_abnormal_reproductive_system0.75000866
132MP0000470_abnormal_stomach_morphology0.74812764
133MP0002127_abnormal_cardiovascular_syste0.74058379
134MP0000759_abnormal_skeletal_muscle0.73944673
135MP0002909_abnormal_adrenal_gland0.72765096
136MP0008789_abnormal_olfactory_epithelium0.72485340
137MP0005167_abnormal_blood-brain_barrier0.72403969
138MP0002396_abnormal_hematopoietic_system0.72254912
139MP0002928_abnormal_bile_duct0.71423699
140MP0006292_abnormal_olfactory_placode0.70657884
141MP0003172_abnormal_lysosome_physiology0.70607265
142MP0008469_abnormal_protein_level0.70144766
143MP0002249_abnormal_larynx_morphology0.69750058
144MP0003763_abnormal_thymus_physiology0.69320846
145MP0000685_abnormal_immune_system0.69106325
146MP0000230_abnormal_systemic_arterial0.68617884
147MP0009642_abnormal_blood_homeostasis0.67975874
148MP0001730_embryonic_growth_arrest0.67871150
149MP0002148_abnormal_hypersensitivity_rea0.67669602
150MP0001485_abnormal_pinna_reflex0.66550268
151MP0005499_abnormal_olfactory_system0.66308274
152MP0005394_taste/olfaction_phenotype0.66308274
153MP0004087_abnormal_muscle_fiber0.65911052
154MP0000681_abnormal_thyroid_gland0.64282704
155MP0002095_abnormal_skin_pigmentation0.63845886
156MP0002234_abnormal_pharynx_morphology0.63490204
157MP0002067_abnormal_sensory_capabilities0.63312901
158MP0001800_abnormal_humoral_immune0.62122895
159MP0005452_abnormal_adipose_tissue0.61315784
160MP0003011_delayed_dark_adaptation0.61225916
161MP0005369_muscle_phenotype0.60720698
162MP0002138_abnormal_hepatobiliary_system0.59486522
163MP0002822_catalepsy0.58471659
164MP0005535_abnormal_body_temperature0.58205594
165MP0003329_amyloid_beta_deposits0.57804543

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)4.99857574
2Acute necrotizing encephalopathy (HP:0006965)4.66293866
3Abnormal mitochondria in muscle tissue (HP:0008316)4.56154014
4Hepatocellular necrosis (HP:0001404)4.52656093
5Hepatic necrosis (HP:0002605)4.47797340
6Mitochondrial inheritance (HP:0001427)4.37587579
7Acute encephalopathy (HP:0006846)4.34571689
8Increased CSF lactate (HP:0002490)4.31837162
9Hyperglycinuria (HP:0003108)3.99229143
10Rib fusion (HP:0000902)3.82162850
11Hyperglycinemia (HP:0002154)3.69735607
12Increased serum lactate (HP:0002151)3.65032851
13Lactic acidosis (HP:0003128)3.63648758
14Cerebral edema (HP:0002181)3.60205692
15Attenuation of retinal blood vessels (HP:0007843)3.59573326
16Progressive macrocephaly (HP:0004481)3.51142945
17Abnormality of serine family amino acid metabolism (HP:0010894)3.50599067
18Abnormality of glycine metabolism (HP:0010895)3.50599067
19Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.30750043
20Decreased activity of mitochondrial respiratory chain (HP:0008972)3.30750043
21Large for gestational age (HP:0001520)3.29777831
22Increased serum pyruvate (HP:0003542)3.27052729
23Abnormality of glycolysis (HP:0004366)3.27052729
24Lethargy (HP:0001254)3.13139591
25Exercise intolerance (HP:0003546)3.12180072
26Increased muscle lipid content (HP:0009058)3.11566150
27Abnormality of dicarboxylic acid metabolism (HP:0010995)3.11251561
28Dicarboxylic aciduria (HP:0003215)3.11251561
29Respiratory failure (HP:0002878)3.11063713
30Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.09828361
31Increased intramyocellular lipid droplets (HP:0012240)3.07775592
32Duplicated collecting system (HP:0000081)3.05918165
33Aplastic anemia (HP:0001915)3.05305545
34Patellar aplasia (HP:0006443)3.01965104
35Lipid accumulation in hepatocytes (HP:0006561)3.00622425
36Abnormality of alanine metabolism (HP:0010916)3.00503395
37Hyperalaninemia (HP:0003348)3.00503395
38Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.00503395
39Aplasia/Hypoplasia of the patella (HP:0006498)2.97663072
40Abnormality of fatty-acid metabolism (HP:0004359)2.96942382
41Hypoglycemic coma (HP:0001325)2.92375840
42Pendular nystagmus (HP:0012043)2.91062228
43Abnormality of the renal collecting system (HP:0004742)2.90338359
44Increased hepatocellular lipid droplets (HP:0006565)2.87801538
45CNS demyelination (HP:0007305)2.85074600
46Decreased circulating renin level (HP:0003351)2.84883289
47Progressive microcephaly (HP:0000253)2.83732790
48Abnormality of aromatic amino acid family metabolism (HP:0004338)2.83456200
49Ketoacidosis (HP:0001993)2.80908137
50Annular pancreas (HP:0001734)2.80512541
51Severe muscular hypotonia (HP:0006829)2.78229199
523-Methylglutaconic aciduria (HP:0003535)2.78005411
53Pancreatic cysts (HP:0001737)2.76803806
54Ketosis (HP:0001946)2.76710519
55Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.75423010
56Mesangial abnormality (HP:0001966)2.72091010
57Abnormality of serum amino acid levels (HP:0003112)2.69841894
58Decreased electroretinogram (ERG) amplitude (HP:0000654)2.69158880
59Gout (HP:0001997)2.64291823
60Cerebral hypomyelination (HP:0006808)2.64207209
61Progressive muscle weakness (HP:0003323)2.63641430
62Methylmalonic aciduria (HP:0012120)2.62627416
63Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.61444665
64Hyperammonemia (HP:0001987)2.59038925
65Molar tooth sign on MRI (HP:0002419)2.57887167
66Abnormality of midbrain morphology (HP:0002418)2.57887167
67Bony spicule pigmentary retinopathy (HP:0007737)2.56088757
68Decreased central vision (HP:0007663)2.55097245
69Renal Fanconi syndrome (HP:0001994)2.53827407
70Polydipsia (HP:0001959)2.52523503
71Abnormal drinking behavior (HP:0030082)2.52523503
72Nephronophthisis (HP:0000090)2.52081604
73Microvesicular hepatic steatosis (HP:0001414)2.50210499
74Ragged-red muscle fibers (HP:0003200)2.47279946
75Rhabdomyolysis (HP:0003201)2.46581222
76Carpal bone hypoplasia (HP:0001498)2.44510478
77Abnormal rod and cone electroretinograms (HP:0008323)2.43387276
78Hypoplasia of the pons (HP:0012110)2.42981272
79Myoglobinuria (HP:0002913)2.35192411
80Reticulocytopenia (HP:0001896)2.32253392
81Pancytopenia (HP:0001876)2.30520958
82Emotional lability (HP:0000712)2.29777730
83Pancreatic fibrosis (HP:0100732)2.29019181
84Multiple enchondromatosis (HP:0005701)2.28198255
85Type II lissencephaly (HP:0007260)2.28029724
86Rectal fistula (HP:0100590)2.25925475
87Rectovaginal fistula (HP:0000143)2.25925475
88True hermaphroditism (HP:0010459)2.22808240
89Ventricular tachycardia (HP:0004756)2.21509267
90Oral leukoplakia (HP:0002745)2.21244530
91Abnormality of the pons (HP:0007361)2.20983066
92Abnormal biliary tract physiology (HP:0012439)2.18784760
93Bile duct proliferation (HP:0001408)2.18784760
94Calf muscle hypertrophy (HP:0008981)2.18083031
95Optic disc pallor (HP:0000543)2.17739924
96Acute lymphatic leukemia (HP:0006721)2.17433371
97Muscle hypertrophy of the lower extremities (HP:0008968)2.16553418
98Palpitations (HP:0001962)2.15751525
99Panhypogammaglobulinemia (HP:0003139)2.15206636
100Aplasia/Hypoplasia involving the musculature (HP:0001460)2.14628107
101Brushfield spots (HP:0001088)2.14201502
102Sudden death (HP:0001699)2.13262125
103Neuroendocrine neoplasm (HP:0100634)2.12169380
104Absent thumb (HP:0009777)2.12094586
105Exertional dyspnea (HP:0002875)2.11881628
106Concave nail (HP:0001598)2.10414440
107Leukodystrophy (HP:0002415)2.09620282
108Abnormal number of erythroid precursors (HP:0012131)2.09307318
109Glycosuria (HP:0003076)2.08252428
110Abnormality of urine glucose concentration (HP:0011016)2.08252428
111Proximal tubulopathy (HP:0000114)2.07911359
112Metabolic acidosis (HP:0001942)2.07569765
113Intestinal fistula (HP:0100819)2.06343825
114Polymicrogyria (HP:0002126)2.06120977
115Aplasia/Hypoplasia of the sacrum (HP:0008517)2.05992425
116Vomiting (HP:0002013)2.05952771
117Pheochromocytoma (HP:0002666)2.05224607
118Breast hypoplasia (HP:0003187)2.04393225
119Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.03630818
120Retinal dysplasia (HP:0007973)2.03496142
121Ileus (HP:0002595)2.03413110
122Chorioretinal atrophy (HP:0000533)2.01553973
123Adactyly (HP:0009776)2.01418173
124Tubular atrophy (HP:0000092)2.00781113
125Abnormality of cells of the erythroid lineage (HP:0012130)1.98526163
126Gliosis (HP:0002171)1.97784413
127Megaloblastic anemia (HP:0001889)1.94721399
128Progressive external ophthalmoplegia (HP:0000590)1.94539386
129Vaginal fistula (HP:0004320)1.94058615
130Cystic liver disease (HP:0006706)1.94007059
131Generalized aminoaciduria (HP:0002909)1.93476249
132Testicular atrophy (HP:0000029)1.93273725
133Increased neuronal autofluorescent lipopigment (HP:0002074)1.92904881
134Hyperinsulinemic hypoglycemia (HP:0000825)1.90814803
135Long foot (HP:0001833)1.90408779
136Abnormality of pyrimidine metabolism (HP:0004353)1.87624496
137Abnormality of the renal medulla (HP:0100957)1.86135882
138Poikiloderma (HP:0001029)1.85954758
139Unsteady gait (HP:0002317)1.85221444
140Delayed CNS myelination (HP:0002188)1.84954344
141Facial hemangioma (HP:0000329)1.84467219
142Opisthotonus (HP:0002179)1.84423573
143Macrocytic anemia (HP:0001972)1.84321988
144Nausea (HP:0002018)1.83722711
145Aplasia of the musculature (HP:0100854)1.83526233
146Abnormality of the heme biosynthetic pathway (HP:0010472)1.82523846
147Respiratory difficulties (HP:0002880)1.82202840
148Abnormal protein glycosylation (HP:0012346)1.81290610
149Abnormal glycosylation (HP:0012345)1.81290610
150Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.81290610
151Abnormal protein N-linked glycosylation (HP:0012347)1.81290610
152Exercise-induced myalgia (HP:0003738)1.81117813
153Medial flaring of the eyebrow (HP:0010747)1.80512326
154Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.80109886
155Vacuolated lymphocytes (HP:0001922)1.79632748
156Microretrognathia (HP:0000308)1.79595347
157Retinitis pigmentosa (HP:0000510)1.78951457
158Abnormal albumin level (HP:0012116)1.78711121
159Hypoalbuminemia (HP:0003073)1.78711121
160Congenital hepatic fibrosis (HP:0002612)1.78332363
161Hypobetalipoproteinemia (HP:0003563)1.77521779
162Birth length less than 3rd percentile (HP:0003561)1.77025446
163Polyuria (HP:0000103)1.74895844
164Tachypnea (HP:0002789)1.74454993
165Rough bone trabeculation (HP:0100670)1.74017126
166Akinesia (HP:0002304)1.73899176
167Abnormality of renal resorption (HP:0011038)1.73857280
168Fetal akinesia sequence (HP:0001989)1.73730516
169Inability to walk (HP:0002540)1.71722948
170Myopathic facies (HP:0002058)1.71655123

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK166.04681504
2MKNK24.07811050
3EIF2AK13.94370562
4BUB13.79209894
5WEE13.32239555
6TLK13.27644436
7BCKDK3.16104746
8MAPK152.87507619
9TAOK32.80781724
10NME22.76334200
11TAOK12.70264133
12INSRR2.39435726
13PDK42.32023296
14PDK32.32023296
15ARAF2.31441072
16EIF2AK32.26768043
17CCNB12.22381497
18OBSCN2.21039407
19TSSK62.10338118
20TAOK22.04191461
21NME12.03818590
22AKT32.01652084
23BRAF1.95984288
24SIK21.94808713
25BMPR1B1.91669772
26ACVR1B1.84930035
27PIM21.83556264
28MKNK11.81968236
29FRK1.74905595
30PINK11.73454510
31MAP4K21.71472114
32NEK11.66121868
33MUSK1.63009851
34WNK31.54476839
35GRK11.49547723
36VRK21.44533727
37BRSK21.44510946
38SRPK11.37600607
39DAPK21.36624127
40CASK1.34286795
41MAP3K31.28062507
42ZAK1.26922582
43IRAK31.26069881
44PRKD21.26025944
45TXK1.25380077
46MYLK1.25278664
47ERN11.18884784
48TNK21.18497347
49JAK31.16463082
50FLT31.12727323
51MAPK131.04703530
52AURKA1.04164391
53VRK11.04070815
54CDK190.97729282
55TBK10.96905653
56DYRK1B0.94899775
57PDK20.93706239
58PNCK0.93395083
59SMG10.92682162
60MAP3K70.92421257
61PRKCI0.92033238
62TESK20.89602847
63BRSK10.87533143
64MAP2K40.83825802
65MAP3K110.80471856
66PRKD30.79113135
67PHKG20.79059068
68PHKG10.79059068
69PLK10.78301440
70DAPK10.77490362
71DAPK30.76466378
72FES0.76178326
73IKBKB0.74776261
74MARK10.73878303
75RPS6KA60.71653359
76CHEK20.71173849
77ADRBK10.71048402
78DYRK1A0.70863913
79MAP2K20.68067546
80LMTK20.67528794
81WNK40.67211769
82BLK0.66728062
83TTN0.64502781
84EPHA20.63550510
85MAP3K40.63394258
86MAP3K10.62538041
87PKN10.62428711
88OXSR10.61946563
89PASK0.61121575
90HIPK20.59888101
91PRKCQ0.59059140
92IRAK40.58274022
93MAPK110.57983595
94MAP4K10.56701514
95CAMKK10.56197806
96KDR0.56154765
97GRK70.55448297
98SIK10.55102350
99PLK40.54649319
100CAMK2G0.54348615
101MAPK120.53295617
102SIK30.53129642
103MAP2K70.52773766
104NUAK10.52556030
105NTRK20.52129510
106ADRBK20.51778144
107CAMK2D0.49630336
108STK240.48637351
109RPS6KC10.47647446
110RPS6KL10.47647446
111DYRK20.45949860
112RPS6KA20.44961204
113PRKAA10.44476479
114CSNK1A10.44155120
115CDK70.43915364
116MAPKAPK30.43810855
117CSNK2A10.43761113
118ABL20.42820375
119FGFR40.42624600
120AURKB0.42452718
121BTK0.41361239
122ATR0.41139310
123MAP2K30.40942449
124PAK10.40024218
125CAMKK20.39905794
126CSNK1G20.39706059
127MARK20.39201152
128DYRK30.38896035
129CSNK2A20.38561744
130PRKCG0.37882962
131KIT0.37492108
132MAPKAPK50.37355058
133TRIB30.37283989
134ZAP700.36453698
135TTK0.36027429
136PRKCH0.35872432
137MAP2K60.35812662
138IRAK10.35427356
139TIE10.34964831
140PLK30.32970899
141EIF2AK20.32211768
142TEC0.31585502
143MAP3K50.31561567
144RAF10.31077872
145NEK20.30211133
146GRK60.29869744
147RPS6KA50.29844309
148SYK0.29041449
149PIK3CG0.28289977
150PKN20.27346767
151TYK20.27074676
152IRAK20.24728882
153CSNK1G30.23098544
154CAMK2B0.21903362
155PRKACA0.21886487
156NEK90.21790460
157CAMK10.21179989

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006044.23421243
2Proteasome_Homo sapiens_hsa030503.24134438
3Oxidative phosphorylation_Homo sapiens_hsa001903.19874811
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.14238944
5RNA polymerase_Homo sapiens_hsa030203.05663866
6Parkinsons disease_Homo sapiens_hsa050122.88023148
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.74337820
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.56888913
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.56663813
10Vitamin B6 metabolism_Homo sapiens_hsa007502.55228200
11Ribosome_Homo sapiens_hsa030102.44713673
12Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.30025851
13DNA replication_Homo sapiens_hsa030302.26095777
14Primary immunodeficiency_Homo sapiens_hsa053402.11975612
15Huntingtons disease_Homo sapiens_hsa050162.06798320
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.04085356
17Pyrimidine metabolism_Homo sapiens_hsa002402.02074964
18Folate biosynthesis_Homo sapiens_hsa007902.01608493
19Propanoate metabolism_Homo sapiens_hsa006402.00238590
20Carbon metabolism_Homo sapiens_hsa012001.94283257
21Nicotine addiction_Homo sapiens_hsa050331.91601351
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.90772955
23Sulfur relay system_Homo sapiens_hsa041221.89130778
24Alzheimers disease_Homo sapiens_hsa050101.88495065
25Pyruvate metabolism_Homo sapiens_hsa006201.85410795
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.78156848
27Taste transduction_Homo sapiens_hsa047421.74601729
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.73890787
29Phototransduction_Homo sapiens_hsa047441.73883579
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.71273662
31Mismatch repair_Homo sapiens_hsa034301.68248397
32Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.65898960
33SNARE interactions in vesicular transport_Homo sapiens_hsa041301.65409516
34Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.61759838
35Biosynthesis of amino acids_Homo sapiens_hsa012301.61754444
36Fatty acid degradation_Homo sapiens_hsa000711.58718657
37Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.57944449
38Protein export_Homo sapiens_hsa030601.56691430
39Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.52010341
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.51049244
41Intestinal immune network for IgA production_Homo sapiens_hsa046721.48396565
42Cardiac muscle contraction_Homo sapiens_hsa042601.47223739
43Butanoate metabolism_Homo sapiens_hsa006501.46207014
44Glycosaminoglycan degradation_Homo sapiens_hsa005311.46063978
45Peroxisome_Homo sapiens_hsa041461.45717450
46Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.45247741
47Linoleic acid metabolism_Homo sapiens_hsa005911.42414985
48Homologous recombination_Homo sapiens_hsa034401.36892050
49One carbon pool by folate_Homo sapiens_hsa006701.33945310
50Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.33363406
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.30248476
52Purine metabolism_Homo sapiens_hsa002301.28894907
53Fatty acid elongation_Homo sapiens_hsa000621.28284639
54Nucleotide excision repair_Homo sapiens_hsa034201.24401240
55Base excision repair_Homo sapiens_hsa034101.23988056
56Drug metabolism - other enzymes_Homo sapiens_hsa009831.22825791
57beta-Alanine metabolism_Homo sapiens_hsa004101.22451109
58Spliceosome_Homo sapiens_hsa030401.20478016
59Pentose phosphate pathway_Homo sapiens_hsa000301.20079929
60Fructose and mannose metabolism_Homo sapiens_hsa000511.12711785
61Ether lipid metabolism_Homo sapiens_hsa005651.08702519
62Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.08319168
63Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.07330120
64Arginine and proline metabolism_Homo sapiens_hsa003301.07257946
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.06717736
66Tryptophan metabolism_Homo sapiens_hsa003801.04751694
67Fatty acid metabolism_Homo sapiens_hsa012121.04210257
68Metabolic pathways_Homo sapiens_hsa011001.02775896
69Glutathione metabolism_Homo sapiens_hsa004800.99867020
70Morphine addiction_Homo sapiens_hsa050320.98902982
71Nitrogen metabolism_Homo sapiens_hsa009100.98140483
72Other glycan degradation_Homo sapiens_hsa005110.97687882
73RNA transport_Homo sapiens_hsa030130.97416038
74ABC transporters_Homo sapiens_hsa020100.94483006
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94016790
76Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.92525551
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.91975879
78Regulation of autophagy_Homo sapiens_hsa041400.90365052
79Cyanoamino acid metabolism_Homo sapiens_hsa004600.90259426
80Lysine degradation_Homo sapiens_hsa003100.90127158
81Galactose metabolism_Homo sapiens_hsa000520.88293315
82Collecting duct acid secretion_Homo sapiens_hsa049660.84644889
83Primary bile acid biosynthesis_Homo sapiens_hsa001200.84078780
84Asthma_Homo sapiens_hsa053100.80328020
85Maturity onset diabetes of the young_Homo sapiens_hsa049500.80270538
86Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.74482891
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.72679136
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72288705
89Selenocompound metabolism_Homo sapiens_hsa004500.72262513
90Olfactory transduction_Homo sapiens_hsa047400.72109349
91Phenylalanine metabolism_Homo sapiens_hsa003600.69850249
92Basal transcription factors_Homo sapiens_hsa030220.69701952
93Synaptic vesicle cycle_Homo sapiens_hsa047210.68633378
94Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.68337422
95Calcium signaling pathway_Homo sapiens_hsa040200.67171841
96Ovarian steroidogenesis_Homo sapiens_hsa049130.65720992
97Fanconi anemia pathway_Homo sapiens_hsa034600.65676146
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64484797
99Histidine metabolism_Homo sapiens_hsa003400.61849337
100Sphingolipid metabolism_Homo sapiens_hsa006000.60269461
101Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56777467
102Tyrosine metabolism_Homo sapiens_hsa003500.56624053
103GABAergic synapse_Homo sapiens_hsa047270.56010134
104Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55899682
105Insulin secretion_Homo sapiens_hsa049110.55432747
106Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.54529544
107Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54248906
108Circadian entrainment_Homo sapiens_hsa047130.53962703
109RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.53594945
110Alcoholism_Homo sapiens_hsa050340.52242639
111Arginine biosynthesis_Homo sapiens_hsa002200.52064431
112Allograft rejection_Homo sapiens_hsa053300.51095186
113Vitamin digestion and absorption_Homo sapiens_hsa049770.49375486
114Steroid hormone biosynthesis_Homo sapiens_hsa001400.48043825
115Graft-versus-host disease_Homo sapiens_hsa053320.46109304
116Cholinergic synapse_Homo sapiens_hsa047250.46096942
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.46003095
118Autoimmune thyroid disease_Homo sapiens_hsa053200.45369080
119Epstein-Barr virus infection_Homo sapiens_hsa051690.41855151
120Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41346370
121Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.41019472
122Cocaine addiction_Homo sapiens_hsa050300.39540155
123Glutamatergic synapse_Homo sapiens_hsa047240.39044055
124Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.37762197
125Arachidonic acid metabolism_Homo sapiens_hsa005900.37666055
126Sulfur metabolism_Homo sapiens_hsa009200.37624146
127Starch and sucrose metabolism_Homo sapiens_hsa005000.36658120
128RNA degradation_Homo sapiens_hsa030180.33927561
129Cell cycle_Homo sapiens_hsa041100.33448923
130Glycerolipid metabolism_Homo sapiens_hsa005610.32796352
131Caffeine metabolism_Homo sapiens_hsa002320.32762499
132Chemical carcinogenesis_Homo sapiens_hsa052040.32010167
133Fat digestion and absorption_Homo sapiens_hsa049750.31861930
134Retinol metabolism_Homo sapiens_hsa008300.31768606
135Type I diabetes mellitus_Homo sapiens_hsa049400.30776101
136Vibrio cholerae infection_Homo sapiens_hsa051100.30002254
137Steroid biosynthesis_Homo sapiens_hsa001000.29036295
138Rheumatoid arthritis_Homo sapiens_hsa053230.27397874
139PPAR signaling pathway_Homo sapiens_hsa033200.27144851
140Oxytocin signaling pathway_Homo sapiens_hsa049210.26919168
141Lysosome_Homo sapiens_hsa041420.25783749
142Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.24928198
143Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24361238
144Renin-angiotensin system_Homo sapiens_hsa046140.22147953
145Systemic lupus erythematosus_Homo sapiens_hsa053220.21398880

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