NARS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Asparaginyl-tRNA synthetase is localized to the cytoplasm and belongs to the class II family of tRNA synthetases. The N-terminal domain represents the signature sequence for the eukaryotic asparaginyl-tRNA synthetases. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of translational termination (GO:0006449)5.57998702
2regulation of translational fidelity (GO:0006450)5.17629336
3folic acid-containing compound biosynthetic process (GO:0009396)5.14824288
4establishment of integrated proviral latency (GO:0075713)5.10750681
5* tRNA aminoacylation for protein translation (GO:0006418)4.96464291
6formation of translation preinitiation complex (GO:0001731)4.80447467
7* amino acid activation (GO:0043038)4.78260349
8* tRNA aminoacylation (GO:0043039)4.78260349
9COPI coating of Golgi vesicle (GO:0048205)4.77537481
10Golgi transport vesicle coating (GO:0048200)4.77537481
11nucleobase biosynthetic process (GO:0046112)4.62896403
12IMP biosynthetic process (GO:0006188)4.57645672
13purine nucleobase biosynthetic process (GO:0009113)4.39156909
14cullin deneddylation (GO:0010388)4.38781349
15peptidyl-arginine omega-N-methylation (GO:0035247)4.37929322
16protein localization to kinetochore (GO:0034501)4.19159047
17nuclear pore organization (GO:0006999)4.18838560
18ribosome assembly (GO:0042255)4.18202674
19protein deneddylation (GO:0000338)4.06069982
20mitotic sister chromatid segregation (GO:0000070)4.03656592
21IMP metabolic process (GO:0046040)3.97663896
22peptidyl-arginine methylation (GO:0018216)3.95090518
23peptidyl-arginine N-methylation (GO:0035246)3.95090518
24oxaloacetate metabolic process (GO:0006107)3.94211715
25histone arginine methylation (GO:0034969)3.86403288
26establishment of viral latency (GO:0019043)3.85919844
27NADH metabolic process (GO:0006734)3.81438754
28regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.80963087
29nuclear pore complex assembly (GO:0051292)3.80256888
30ribosome biogenesis (GO:0042254)3.80065692
31mitotic sister chromatid cohesion (GO:0007064)3.74802664
32regulation of translational elongation (GO:0006448)3.70722832
33sister chromatid segregation (GO:0000819)3.70612416
34mitotic nuclear envelope disassembly (GO:0007077)3.67881047
35cellular protein complex localization (GO:0034629)3.66665184
36protein complex localization (GO:0031503)3.63775477
37nuclear envelope disassembly (GO:0051081)3.58380369
38membrane disassembly (GO:0030397)3.58380369
39de novo protein folding (GO:0006458)3.58325291
40DNA unwinding involved in DNA replication (GO:0006268)3.54404263
41chaperone-mediated protein complex assembly (GO:0051131)3.53660364
42DNA strand elongation (GO:0022616)3.48241501
43non-recombinational repair (GO:0000726)3.48024058
44double-strand break repair via nonhomologous end joining (GO:0006303)3.48024058
45de novo posttranslational protein folding (GO:0051084)3.43692365
46mitotic metaphase plate congression (GO:0007080)3.38742185
47establishment of protein localization to mitochondrial membrane (GO:0090151)3.36047386
48CENP-A containing nucleosome assembly (GO:0034080)3.35508906
49chromatin remodeling at centromere (GO:0031055)3.29156219
50mitotic spindle checkpoint (GO:0071174)3.24711372
51RNA-dependent DNA replication (GO:0006278)3.23135389
52DNA replication initiation (GO:0006270)3.22904722
53spindle checkpoint (GO:0031577)3.21690320
54nucleobase-containing small molecule interconversion (GO:0015949)3.20535249
55negative regulation of sister chromatid segregation (GO:0033046)3.18810983
56negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.18810983
57negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.18810983
58negative regulation of mitotic sister chromatid segregation (GO:0033048)3.18810983
59negative regulation of mitotic sister chromatid separation (GO:2000816)3.18810983
60negative regulation of chromosome segregation (GO:0051985)3.17496298
61mitotic chromosome condensation (GO:0007076)3.15915061
62negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.14825307
63tetrahydrofolate metabolic process (GO:0046653)3.14257922
64regulation of centriole replication (GO:0046599)3.14150572
65energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.13851248
66ATP hydrolysis coupled proton transport (GO:0015991)3.13851248
67DNA topological change (GO:0006265)3.12995560
68serine family amino acid biosynthetic process (GO:0009070)3.12326258
69DNA ligation (GO:0006266)3.11630471
70positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.11230206
71anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.10069125
72regulation of chromosome segregation (GO:0051983)3.09968710
73transferrin transport (GO:0033572)3.09801988
74telomere maintenance via semi-conservative replication (GO:0032201)3.06115916
75pore complex assembly (GO:0046931)3.04750795
76protein-cofactor linkage (GO:0018065)3.03153392
77regulation of mitotic metaphase/anaphase transition (GO:0030071)3.00793539
78regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.00793539
79regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.98341312
80mitotic spindle assembly checkpoint (GO:0007094)2.98097624
81postreplication repair (GO:0006301)2.97437079
82tricarboxylic acid cycle (GO:0006099)2.96787161
83spindle assembly checkpoint (GO:0071173)2.95323823
84G1/S transition of mitotic cell cycle (GO:0000082)2.94610153
85cell cycle G1/S phase transition (GO:0044843)2.94610153
86telomere maintenance via telomerase (GO:0007004)2.94166639
87ferric iron transport (GO:0015682)2.94058804
88trivalent inorganic cation transport (GO:0072512)2.94058804
89regulation of translational initiation (GO:0006446)2.93530518
90proteasome assembly (GO:0043248)2.92446705
91cellular response to glucose starvation (GO:0042149)2.91838275
92negative regulation of ligase activity (GO:0051352)2.89953686
93negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.89953686
94glutamine metabolic process (GO:0006541)2.88323651
95regulation of spindle organization (GO:0090224)2.88162145
96regulation of sister chromatid segregation (GO:0033045)2.88009750
97regulation of mitotic sister chromatid separation (GO:0010965)2.88009750
98regulation of mitotic sister chromatid segregation (GO:0033047)2.88009750
99histone exchange (GO:0043486)2.87391667
100regulation of translation in response to stress (GO:0043555)2.87227625
101DNA replication-independent nucleosome assembly (GO:0006336)2.86770336
102DNA replication-independent nucleosome organization (GO:0034724)2.86770336
103positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.86037604
104regulation of mitotic spindle organization (GO:0060236)2.85760199
105DNA double-strand break processing (GO:0000729)2.84483858
106DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.81989597
107synaptic vesicle docking involved in exocytosis (GO:0016081)2.81888096
108regulation of cellular amino acid metabolic process (GO:0006521)2.81510689
109regulation of centrosome cycle (GO:0046605)2.80763027
110establishment of chromosome localization (GO:0051303)2.79468692
111regulation of oxidative stress-induced neuron death (GO:1903203)2.78926796
112ER overload response (GO:0006983)2.78766207
113intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.78240151
114signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.78240151
115L-serine metabolic process (GO:0006563)2.77517319
116L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.77067171
117COPII vesicle coating (GO:0048208)2.75933548
118signal transduction involved in DNA integrity checkpoint (GO:0072401)2.74860591
119signal transduction involved in DNA damage checkpoint (GO:0072422)2.74860591
120mitochondrial DNA metabolic process (GO:0032042)2.74011642
121protein localization to chromosome, centromeric region (GO:0071459)2.73827777
122mitotic recombination (GO:0006312)2.72579478
123signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.71154772
124signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.71154772
125signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.71154772
126aspartate family amino acid biosynthetic process (GO:0009067)2.70643485
127signal transduction involved in cell cycle checkpoint (GO:0072395)2.70013668
128DNA replication-dependent nucleosome assembly (GO:0006335)2.69357018
129DNA replication-dependent nucleosome organization (GO:0034723)2.69357018
130metaphase plate congression (GO:0051310)2.68917128
131positive regulation of chromosome segregation (GO:0051984)2.68079030
132maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.67606162
133ribonucleoprotein complex biogenesis (GO:0022613)2.66771373
134positive regulation of ligase activity (GO:0051351)2.65779999
135response to X-ray (GO:0010165)2.65330255
136regulation of ubiquitin-protein transferase activity (GO:0051438)2.65255143
137pteridine-containing compound biosynthetic process (GO:0042559)2.63850648
138nucleotide-sugar biosynthetic process (GO:0009226)2.63480535
139positive regulation of nuclease activity (GO:0032075)2.61346675
140telomere maintenance via recombination (GO:0000722)2.61045035
141DNA duplex unwinding (GO:0032508)2.60809933
142DNA geometric change (GO:0032392)2.60726034
143activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.60609838
144nuclear envelope organization (GO:0006998)2.60248886
145chaperone-mediated protein folding (GO:0061077)2.60170867
146galactose catabolic process (GO:0019388)2.59741953
147heterochromatin organization (GO:0070828)2.57967290
148regulation of helicase activity (GO:0051095)2.57930995
149DNA replication checkpoint (GO:0000076)2.57766366
150regulation of sister chromatid cohesion (GO:0007063)2.57763888
151ribosomal large subunit biogenesis (GO:0042273)2.57465546
152DNA strand elongation involved in DNA replication (GO:0006271)2.56562605

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.01430115
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.72020061
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.36190558
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.55635609
5* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.34232070
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.31370272
7* ETS1_20019798_ChIP-Seq_JURKAT_Human3.19106468
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.06839094
9E2F4_17652178_ChIP-ChIP_JURKAT_Human3.06705340
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse3.06587824
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.03874647
12GABP_17652178_ChIP-ChIP_JURKAT_Human3.02382866
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.95384172
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.86381951
15* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.79751342
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.71162196
17NELFA_20434984_ChIP-Seq_ESCs_Mouse2.69900969
18* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.63507153
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.60429028
20THAP11_20581084_ChIP-Seq_MESCs_Mouse2.59549020
21ESR1_15608294_ChIP-ChIP_MCF-7_Human2.38846784
22AR_21909140_ChIP-Seq_LNCAP_Human2.31077521
23PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.30588799
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.26473065
25POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.26343120
26XRN2_22483619_ChIP-Seq_HELA_Human2.22315104
27FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.22179372
28* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.21911651
29ELK1_19687146_ChIP-ChIP_HELA_Human2.18570001
30DCP1A_22483619_ChIP-Seq_HELA_Human2.17353388
31POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.13845121
32MYCN_18555785_ChIP-Seq_MESCs_Mouse2.13391293
33* VDR_23849224_ChIP-Seq_CD4+_Human2.10505043
34* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.08218777
35RBPJ_22232070_ChIP-Seq_NCS_Mouse1.99578004
36NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.99041370
37GABP_19822575_ChIP-Seq_HepG2_Human1.93998093
38* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.93446209
39PADI4_21655091_ChIP-ChIP_MCF-7_Human1.93062386
40FOXP3_21729870_ChIP-Seq_TREG_Human1.86073438
41TTF2_22483619_ChIP-Seq_HELA_Human1.86016426
42TFEB_21752829_ChIP-Seq_HELA_Human1.80258127
43PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.79660142
44ZFX_18555785_ChIP-Seq_MESCs_Mouse1.79311249
45MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.79157142
46NANOG_18555785_ChIP-Seq_MESCs_Mouse1.75466746
47* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.70323099
48E2F1_21310950_ChIP-Seq_MCF-7_Human1.66699285
49KDM5A_27292631_Chip-Seq_BREAST_Human1.66504830
50MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.63234297
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.61424541
52STAT3_1855785_ChIP-Seq_MESCs_Mouse1.52861987
53ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.51838328
54* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.51747104
55CLOCK_20551151_ChIP-Seq_293T_Human1.47384367
56CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.43062135
57FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.38523803
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.36863086
59POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.35831170
60TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.32879425
61SALL1_21062744_ChIP-ChIP_HESCs_Human1.32755336
62SRF_21415370_ChIP-Seq_HL-1_Mouse1.30697726
63WT1_19549856_ChIP-ChIP_CCG9911_Human1.30072672
64PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.28494274
65CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.26918370
66KLF4_18555785_ChIP-Seq_MESCs_Mouse1.26672339
67CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.23966818
68ELK1_22589737_ChIP-Seq_MCF10A_Human1.23808888
69ZNF263_19887448_ChIP-Seq_K562_Human1.21974715
70MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.19150658
71NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.18450829
72* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.15867917
73SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.13729568
74KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.11717756
75SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.08337882
76SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.08196299
77CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.07963535
78* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.07910628
79SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.07360623
80* ATF3_27146783_Chip-Seq_COLON_Human1.05941739
81ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.05846564
82CHD1_26751641_Chip-Seq_LNCaP_Human1.05657008
83FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.05378812
84HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.04928542
85ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.04850957
86NANOG_16153702_ChIP-ChIP_HESCs_Human1.03302101
87ELF1_17652178_ChIP-ChIP_JURKAT_Human1.03133370
88TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.02764508
89HIF1A_21447827_ChIP-Seq_MCF-7_Human1.02523461
90ERG_20887958_ChIP-Seq_HPC-7_Mouse1.01128068
91* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.99217556
92EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.98345914
93TCF3_18692474_ChIP-Seq_MEFs_Mouse0.97527869
94TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97282779
95OCT4_18692474_ChIP-Seq_MEFs_Mouse0.97054496
96* ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.96710672
97E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.96697281
98* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.96606964
99SOX2_18555785_ChIP-Seq_MESCs_Mouse0.96204620
100* MYC_22102868_ChIP-Seq_BL_Human0.95538708
101SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.95041431
102NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.94356828
103BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93655293
104SOX17_20123909_ChIP-Seq_XEN_Mouse0.93639617
105E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.93564618
106PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.92911971
107* CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.91268018
108NANOG_21062744_ChIP-ChIP_HESCs_Human0.90366969
109* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.90309619
110NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.89364349
111DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.89140046
112SOX2_16153702_ChIP-ChIP_HESCs_Human0.89058975
113HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.87238815
114ELF5_23300383_ChIP-Seq_T47D_Human0.86917556
115* CIITA_25753668_ChIP-Seq_RAJI_Human0.86752797
116* GATA4_21415370_ChIP-Seq_HL-1_Mouse0.84848309
117SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.84365362

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003941_abnormal_skin_development4.11498991
2MP0004957_abnormal_blastocyst_morpholog3.90036051
3MP0003693_abnormal_embryo_hatching3.84842192
4MP0003123_paternal_imprinting3.50211667
5MP0010352_gastrointestinal_tract_polyps3.33597466
6MP0003111_abnormal_nucleus_morphology2.72683349
7MP0010094_abnormal_chromosome_stability2.63778659
8MP0003705_abnormal_hypodermis_morpholog2.59633153
9MP0003077_abnormal_cell_cycle2.58645148
10MP0008438_abnormal_cutaneous_collagen2.51432802
11MP0004233_abnormal_muscle_weight2.50339895
12MP0010307_abnormal_tumor_latency2.37946996
13MP0008932_abnormal_embryonic_tissue2.30076323
14MP0002735_abnormal_chemical_nociception2.07094893
15MP0002877_abnormal_melanocyte_morpholog1.98111891
16MP0001730_embryonic_growth_arrest1.95579594
17MP0003806_abnormal_nucleotide_metabolis1.91815817
18MP0000350_abnormal_cell_proliferation1.91795542
19MP0009697_abnormal_copulation1.90271414
20MP0009780_abnormal_chondrocyte_physiolo1.89662111
21MP0004272_abnormal_basement_membrane1.80484358
22MP0003566_abnormal_cell_adhesion1.77864154
23MP0002736_abnormal_nociception_after1.71795542
24MP0008007_abnormal_cellular_replicative1.70947525
25MP0009046_muscle_twitch1.69853694
26MP0009672_abnormal_birth_weight1.63664497
27MP0005623_abnormal_meninges_morphology1.62803118
28MP0004859_abnormal_synaptic_plasticity1.62741021
29MP0005408_hypopigmentation1.60784617
30MP0001542_abnormal_bone_strength1.60671458
31MP0008057_abnormal_DNA_replication1.57324123
32MP0003787_abnormal_imprinting1.56647343
33MP0005076_abnormal_cell_differentiation1.56133280
34MP0003121_genomic_imprinting1.55243722
35MP0000358_abnormal_cell_content/1.53941384
36MP0001697_abnormal_embryo_size1.51734198
37MP0002080_prenatal_lethality1.46482299
38MP0001968_abnormal_touch/_nociception1.44816097
39MP0004197_abnormal_fetal_growth/weight/1.42233698
40MP0001299_abnormal_eye_distance/1.41845576
41MP0008058_abnormal_DNA_repair1.40502339
42MP0005023_abnormal_wound_healing1.40174448
43MP0004270_analgesia1.36702507
44MP0003283_abnormal_digestive_organ1.36189960
45MP0005503_abnormal_tendon_morphology1.36161956
46MP0003122_maternal_imprinting1.35265017
47MP0002734_abnormal_mechanical_nocicepti1.34807832
48MP0001672_abnormal_embryogenesis/_devel1.33873559
49MP0005380_embryogenesis_phenotype1.33873559
50MP0000537_abnormal_urethra_morphology1.31866689
51MP0000013_abnormal_adipose_tissue1.30883405
52MP0006054_spinal_hemorrhage1.30843482
53MP0003937_abnormal_limbs/digits/tail_de1.28874393
54MP0003567_abnormal_fetal_cardiomyocyte1.27412638
55MP0003984_embryonic_growth_retardation1.27339107
56MP0002084_abnormal_developmental_patter1.24425689
57MP0002088_abnormal_embryonic_growth/wei1.24386395
58MP0000579_abnormal_nail_morphology1.23574066
59MP0005275_abnormal_skin_tensile1.22296427
60MP0003635_abnormal_synaptic_transmissio1.19545437
61MP0002796_impaired_skin_barrier1.18357054
62MP0001293_anophthalmia1.17029156
63MP0005384_cellular_phenotype1.16431075
64MP0008877_abnormal_DNA_methylation1.16361556
65MP0001348_abnormal_lacrimal_gland1.15554559
66MP0001661_extended_life_span1.15379847
67MP0002090_abnormal_vision1.12939360
68MP0002064_seizures1.12891851
69MP0005621_abnormal_cell_physiology1.12851348
70MP0004811_abnormal_neuron_physiology1.10814161
71MP0002697_abnormal_eye_size1.10128350
72MP0005501_abnormal_skin_physiology1.09989669
73MP0002086_abnormal_extraembryonic_tissu1.09727611
74MP0006035_abnormal_mitochondrial_morpho1.08806761
75MP0003718_maternal_effect1.08796993
76MP0003186_abnormal_redox_activity1.06759833
77MP0001915_intracranial_hemorrhage1.06453069
78MP0006036_abnormal_mitochondrial_physio1.06197240
79MP0002060_abnormal_skin_morphology1.05173532
80MP0002085_abnormal_embryonic_tissue1.03206867
81MP0003656_abnormal_erythrocyte_physiolo1.02836453
82MP0008004_abnormal_stomach_pH1.02533659
83MP0003950_abnormal_plasma_membrane1.00390389
84MP0002269_muscular_atrophy0.98465971
85MP0003890_abnormal_embryonic-extraembry0.97844465
86MP0003786_premature_aging0.97281954
87MP0002063_abnormal_learning/memory/cond0.96852623
88MP0002733_abnormal_thermal_nociception0.96732040
89MP0009745_abnormal_behavioral_response0.95889747
90MP0002896_abnormal_bone_mineralization0.95771214
91MP0004147_increased_porphyrin_level0.94129790
92MP0000467_abnormal_esophagus_morphology0.94031318
93MP0003385_abnormal_body_wall0.93533246
94MP0004185_abnormal_adipocyte_glucose0.91275132
95MP0002254_reproductive_system_inflammat0.90732950
96MP0000747_muscle_weakness0.89790735
97MP0001849_ear_inflammation0.89352591
98MP0000647_abnormal_sebaceous_gland0.88390287
99MP0002751_abnormal_autonomic_nervous0.88271762
100MP0009053_abnormal_anal_canal0.87747645
101MP0002396_abnormal_hematopoietic_system0.85829984
102MP0000750_abnormal_muscle_regeneration0.85499885
103MP0000762_abnormal_tongue_morphology0.84990448
104MP0004264_abnormal_extraembryonic_tissu0.84304768
105MP0002111_abnormal_tail_morphology0.83630028
106MP0001188_hyperpigmentation0.83110192
107MP0001177_atelectasis0.83072767
108MP0005266_abnormal_metabolism0.83060458
109MP0004858_abnormal_nervous_system0.82527595
110MP0003879_abnormal_hair_cell0.81630959
111MP0001970_abnormal_pain_threshold0.81030537
112MP0000749_muscle_degeneration0.80841069
113MP0005187_abnormal_penis_morphology0.79595889
114MP0002233_abnormal_nose_morphology0.79528539
115MP0000751_myopathy0.78919356
116MP0003119_abnormal_digestive_system0.78716104
117MP0000490_abnormal_crypts_of0.78250127
118MP0004084_abnormal_cardiac_muscle0.78235155
119MP0000858_altered_metastatic_potential0.77710426
120MP0000377_abnormal_hair_follicle0.77231625
121MP0000313_abnormal_cell_death0.74914455
122MP0005257_abnormal_intraocular_pressure0.74263464
123MP0002102_abnormal_ear_morphology0.74105913
124MP0002009_preneoplasia0.73869326
125MP0001286_abnormal_eye_development0.73610156
126MP0004215_abnormal_myocardial_fiber0.72614938
127MP0001243_abnormal_dermal_layer0.72542539
128MP0010234_abnormal_vibrissa_follicle0.72017679
129MP0008260_abnormal_autophagy0.71327064
130MP0005171_absent_coat_pigmentation0.71093945
131MP0000627_abnormal_mammary_gland0.70230771
132MP0003221_abnormal_cardiomyocyte_apopto0.69822476
133MP0004133_heterotaxia0.69085535
134MP0001501_abnormal_sleep_pattern0.69071123
135MP0002184_abnormal_innervation0.69046293
136MP0010386_abnormal_urinary_bladder0.68895109
137MP0003091_abnormal_cell_migration0.68833902
138MP0002092_abnormal_eye_morphology0.68651769
139MP0005330_cardiomyopathy0.68004632
140MP0006072_abnormal_retinal_apoptosis0.67639887
141MP0002572_abnormal_emotion/affect_behav0.67557995
142MP0002019_abnormal_tumor_incidence0.67399296
143MP0001529_abnormal_vocalization0.67236460
144MP0009703_decreased_birth_body0.67095561
145MP0002272_abnormal_nervous_system0.66387168
146MP0000428_abnormal_craniofacial_morphol0.65075066
147MP0000432_abnormal_head_morphology0.63938082
148MP0001216_abnormal_epidermal_layer0.62655890

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)4.01327612
2Multiple enchondromatosis (HP:0005701)3.84552006
3Irregular epiphyses (HP:0010582)3.76605197
4Atonic seizures (HP:0010819)3.62525178
5Resting tremor (HP:0002322)3.43732323
6Chromsome breakage (HP:0040012)3.38294513
7Chromosomal breakage induced by crosslinking agents (HP:0003221)3.23089677
8Cervical subluxation (HP:0003308)3.21816646
9Abnormality of the anterior horn cell (HP:0006802)3.11846249
10Degeneration of anterior horn cells (HP:0002398)3.11846249
11Protrusio acetabuli (HP:0003179)3.02265215
12Shoulder girdle muscle weakness (HP:0003547)2.94987177
13Increased nuchal translucency (HP:0010880)2.94986994
14Hypoplasia of the pons (HP:0012110)2.94551470
15Birth length less than 3rd percentile (HP:0003561)2.93163525
16Abnormality of methionine metabolism (HP:0010901)2.90664579
17Exercise-induced muscle cramps (HP:0003710)2.84256989
18Abnormality of glycolysis (HP:0004366)2.82324678
19Increased serum pyruvate (HP:0003542)2.82324678
20Microvesicular hepatic steatosis (HP:0001414)2.80055261
21Agnosia (HP:0010524)2.78284983
22Nephroblastoma (Wilms tumor) (HP:0002667)2.76504572
23Cortical dysplasia (HP:0002539)2.72552556
24Hand muscle atrophy (HP:0009130)2.72242932
25Embryonal renal neoplasm (HP:0011794)2.69548754
26Premature rupture of membranes (HP:0001788)2.69524327
27Insidious onset (HP:0003587)2.69360036
28Termporal pattern (HP:0011008)2.69360036
29Long foot (HP:0001833)2.67948623
30Progressive external ophthalmoplegia (HP:0000590)2.55570685
31Impaired pain sensation (HP:0007328)2.51730357
32Abnormality of pain sensation (HP:0010832)2.51730357
33Cerebral hypomyelination (HP:0006808)2.51477884
34Rhabdomyosarcoma (HP:0002859)2.48431685
35Postnatal microcephaly (HP:0005484)2.48038727
36Spinal cord compression (HP:0002176)2.44123864
37Upper limb muscle weakness (HP:0003484)2.43673931
38Ependymoma (HP:0002888)2.43416576
39Abnormality of the pons (HP:0007361)2.41900056
40Abnormal lung lobation (HP:0002101)2.40247703
41Vertebral compression fractures (HP:0002953)2.38316899
42Colon cancer (HP:0003003)2.36266329
43Abnormality of the astrocytes (HP:0100707)2.35697002
44Astrocytoma (HP:0009592)2.35697002
45Atrophy/Degeneration involving motor neurons (HP:0007373)2.34844291
46Focal motor seizures (HP:0011153)2.34261540
47Abnormality of the calcaneus (HP:0008364)2.34245772
48Carpal bone hypoplasia (HP:0001498)2.33913040
49Absence seizures (HP:0002121)2.33080480
50Pelvic girdle muscle weakness (HP:0003749)2.31999555
51Distal upper limb amyotrophy (HP:0007149)2.30355279
52Upper limb amyotrophy (HP:0009129)2.30355279
53Abnormality of the umbilical cord (HP:0010881)2.30341262
54Autoamputation (HP:0001218)2.26965423
55Mild short stature (HP:0003502)2.26053833
56Neoplasm of the colon (HP:0100273)2.25080600
57Abnormality of chromosome stability (HP:0003220)2.24598181
58Medulloblastoma (HP:0002885)2.24550342
59Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.23136089
60Abnormal gallbladder physiology (HP:0012438)2.23084866
61Cholecystitis (HP:0001082)2.23084866
62Pterygium (HP:0001059)2.22517396
63Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.21608766
64Absent epiphyses (HP:0010577)2.21608766
65Abnormalities of placenta or umbilical cord (HP:0001194)2.21425628
66Selective tooth agenesis (HP:0001592)2.20768911
67Neoplasm of the adrenal gland (HP:0100631)2.18939736
68Hypoplasia of the odontoid process (HP:0003311)2.14400222
69Hypoplasia of the capital femoral epiphysis (HP:0003090)2.13245799
70Hypoglycemic seizures (HP:0002173)2.12768923
71Pancreatic islet-cell hyperplasia (HP:0004510)2.11369389
72Papillary thyroid carcinoma (HP:0002895)2.11219760
73Abnormality of serum amino acid levels (HP:0003112)2.08310712
74Abnormal cartilage morphology (HP:0002763)2.07259316
75Neoplasm of the small intestine (HP:0100833)2.06360707
76Delayed puberty (HP:0000823)2.06058900
77Breech presentation (HP:0001623)2.04546537
78Epiphyseal dysplasia (HP:0002656)2.04456279
79Abnormality of the preputium (HP:0100587)2.04267242
80Emotional lability (HP:0000712)2.01561732
81Hypoglycemic coma (HP:0001325)2.01049362
82Megaloblastic anemia (HP:0001889)2.00966549
83Cutaneous melanoma (HP:0012056)2.00881906
84Meckel diverticulum (HP:0002245)2.00107678
85Vertebral hypoplasia (HP:0008417)1.99372294
86Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.99372294
87Neuroblastoma (HP:0003006)1.99166869
88Primitive neuroectodermal tumor (HP:0030065)1.99166869
89Neuroblastic tumors (HP:0004376)1.99166869
90Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.99166869
91Ankyloglossia (HP:0010296)1.99121290
92Spinal muscular atrophy (HP:0007269)1.99112162
93Abnormality of the musculature of the pelvis (HP:0001469)1.98285880
94Abnormality of the hip-girdle musculature (HP:0001445)1.98285880
95Abnormality of placental membranes (HP:0011409)1.97055339
96Amniotic constriction ring (HP:0009775)1.97055339
97Angiofibromas (HP:0010615)1.96194121
98Adenoma sebaceum (HP:0009720)1.96194121
99Wrist flexion contracture (HP:0001239)1.96169854
100Tongue fasciculations (HP:0001308)1.95865471
101Abnormality of the odontoid process (HP:0003310)1.94608877
102Epileptic encephalopathy (HP:0200134)1.94076646
103Trismus (HP:0000211)1.93585985
104Progressive muscle weakness (HP:0003323)1.93314232
105Spastic diplegia (HP:0001264)1.90653999
106Dialeptic seizures (HP:0011146)1.88407832
107Poor suck (HP:0002033)1.88017874
108Muscle fibrillation (HP:0010546)1.87881080
109Abnormality of aspartate family amino acid metabolism (HP:0010899)1.87865067
110Coxa vara (HP:0002812)1.87515751
111Symptomatic seizures (HP:0011145)1.87175470
112Reduced antithrombin III activity (HP:0001976)1.86658094
113Freckling (HP:0001480)1.85267227
114Deviation of the thumb (HP:0009603)1.85147777
115Neoplasm of the rectum (HP:0100743)1.84520256
116Proximal placement of thumb (HP:0009623)1.84435197
117Ovarian neoplasm (HP:0100615)1.83994923
118Abnormal auditory evoked potentials (HP:0006958)1.83627405
119Increased density of long bones (HP:0006392)1.82940725
120Abnormality of the proximal phalanges of the hand (HP:0009834)1.82312110
121Disproportionate short-trunk short stature (HP:0003521)1.79332959
122Metaphyseal cupping (HP:0003021)1.79218135
123Abnormality of the ileum (HP:0001549)1.78445096
124Abnormal mitochondria in muscle tissue (HP:0008316)1.78308360
125Increased hepatocellular lipid droplets (HP:0006565)1.77893771
126Hammertoe (HP:0001765)1.77776689
127Cupped ribs (HP:0000887)1.77711035
128Ankle contracture (HP:0006466)1.77598916
129Stillbirth (HP:0003826)1.77173395
130Neoplasm of the peripheral nervous system (HP:0100007)1.77121883
131Biliary tract neoplasm (HP:0100574)1.77049985
132Abnormal umbilical cord blood vessels (HP:0011403)1.76968634
133Single umbilical artery (HP:0001195)1.76968634
134Abnormality of the fetal cardiovascular system (HP:0010948)1.76968634
135Delayed gross motor development (HP:0002194)1.76456894
136Overlapping toe (HP:0001845)1.76299706
137Uterine neoplasm (HP:0010784)1.75896737
138Small intestinal stenosis (HP:0012848)1.75584569
139Duodenal stenosis (HP:0100867)1.75584569
140Breast hypoplasia (HP:0003187)1.75345149
141Volvulus (HP:0002580)1.75274134
142Hyperinsulinemic hypoglycemia (HP:0000825)1.75101211
143Right ventricular cardiomyopathy (HP:0011663)1.74785271
144Sensory axonal neuropathy (HP:0003390)1.74178310
145Glossoptosis (HP:0000162)1.72718982
146Acute necrotizing encephalopathy (HP:0006965)1.72591023
147Rough bone trabeculation (HP:0100670)1.72328842
148Insomnia (HP:0100785)1.71893964
149Abnormality of the lower motor neuron (HP:0002366)1.70817981
150Neuroendocrine neoplasm (HP:0100634)1.70803939
151Athetosis (HP:0002305)1.70334825
152Genu recurvatum (HP:0002816)1.70054029
153Large hands (HP:0001176)1.69825313
154Flat acetabular roof (HP:0003180)1.69160561
155Hyperalaninemia (HP:0003348)1.69079743
156Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.69079743
157Abnormality of alanine metabolism (HP:0010916)1.69079743
158Failure to thrive in infancy (HP:0001531)1.68982628
159Glioma (HP:0009733)1.68837149
160Abnormal hair whorl (HP:0010721)1.67477147
161Embryonal neoplasm (HP:0002898)1.67294951
162Breast carcinoma (HP:0003002)1.66921633
163Type I transferrin isoform profile (HP:0003642)1.66921613
164Beaking of vertebral bodies (HP:0004568)1.66800054
165Abnormality of oral frenula (HP:0000190)1.66383830
166Homocystinuria (HP:0002156)1.66201562
167Abnormality of homocysteine metabolism (HP:0010919)1.66201562
168Febrile seizures (HP:0002373)1.66177867
169Pheochromocytoma (HP:0002666)1.65919093
170Focal seizures (HP:0007359)1.65880066
171Palpitations (HP:0001962)1.65746303
172Abnormality of glycine metabolism (HP:0010895)1.65613193

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TSSK64.97731805
2NEK13.79019169
3EIF2AK13.38137648
4PBK3.35840960
5EPHA22.78595090
6SCYL22.72682242
7CDC72.61174901
8BUB12.52844333
9AKT32.35300061
10PLK22.30404307
11WEE12.20976034
12EIF2AK32.18819002
13MAP3K122.15556011
14PLK32.09458888
15PDK32.01161182
16PDK42.01161182
17NME11.88775676
18TRIM281.80900608
19LIMK11.77693258
20LATS21.66119281
21TESK11.60709058
22EEF2K1.53782679
23CASK1.52482823
24MAP3K41.49877295
25NTRK31.44867162
26PDK21.44030092
27BCR1.43410327
28RPS6KB21.36144221
29PIM21.32329630
30TTK1.29148097
31CCNB11.28810179
32ERBB41.28545035
33MINK11.27456702
34PASK1.27380825
35TESK21.25692278
36PNCK1.25413065
37PAK41.24946318
38DAPK11.24044135
39TAF11.22036923
40MST1R1.18836478
41ALK1.17478539
42BRSK21.16471326
43LATS11.13882028
44DDR21.11021497
45CDK61.07508432
46BRAF1.07434992
47PLK11.06330822
48EIF2AK21.02830580
49MAP3K91.02067837
50PKN21.00830848
51VRK20.99438812
52BRSK10.96236845
53AURKA0.95603863
54MST40.94701788
55ZAK0.91837576
56NEK20.91116939
57SRPK10.85513327
58CDK80.83932163
59MKNK10.83346657
60STK30.81913237
61MAP2K70.81710879
62ERBB30.79655797
63MAP3K80.79088313
64SMG10.78408518
65MAPKAPK30.76304726
66MAP2K40.76030182
67PDGFRA0.75746094
68STK390.75719294
69ARAF0.75595120
70BRD40.74888296
71AURKB0.74726456
72CLK10.74504168
73RPS6KA40.72064224
74MAP3K100.71554460
75CDK140.71022189
76CHEK10.70186606
77ATR0.69866664
78PRKCI0.69219789
79CDK70.68466774
80CAMKK20.67993276
81TTN0.67168844
82TNIK0.67084334
83CSNK1G10.66773405
84CDK180.66399877
85NTRK10.64653995
86FGFR10.63632835
87MAP2K10.63032539
88PRKCG0.63023296
89FER0.62133678
90CDK150.62043267
91NEK90.61783607
92PLK40.57219912
93STK100.55138685
94CSNK2A20.54490024
95CSNK1G30.54229134
96RPS6KB10.53391584
97TAOK20.53390858
98CSNK1E0.52298808
99CAMKK10.51834508
100CSNK1A1L0.51561578
101CDK11A0.51384148
102NEK60.51100863
103MAPKAPK50.51027264
104MAP3K110.50845566
105CSNK1G20.50264986
106PAK10.49090318
107CDK190.48617603
108CDK20.48169608
109MAP3K30.48008341
110STK240.47426044
111MAP3K50.46508438
112PTK20.45651196
113ACVR1B0.43889538
114PRKDC0.42157294
115PAK20.41619812
116YES10.40747843
117STK160.40329498
118VRK10.40066329
119NME20.38570846
120MET0.38543325
121STK38L0.38315289
122AKT20.38223740
123CDK10.38008876
124WNK40.37223655
125GRK50.36293967
126KSR10.36091060
127CSNK2A10.35338573
128ROCK20.34991512
129DMPK0.33804341
130ATM0.33786453
131FLT30.33436288
132MKNK20.33174470
133CHEK20.30901769
134DAPK30.30700269
135CDK120.30105640
136FRK0.29554403

Predicted pathways (KEGG)

RankGene SetZ-score
1* Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009704.61400796
2Proteasome_Homo sapiens_hsa030503.76032929
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.34061921
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.31948014
5One carbon pool by folate_Homo sapiens_hsa006702.92852603
6RNA transport_Homo sapiens_hsa030132.89498761
7Synaptic vesicle cycle_Homo sapiens_hsa047212.72187283
8Collecting duct acid secretion_Homo sapiens_hsa049662.58251896
9DNA replication_Homo sapiens_hsa030302.36686540
10Vibrio cholerae infection_Homo sapiens_hsa051102.30588158
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.18077533
12Mismatch repair_Homo sapiens_hsa034302.09052337
13RNA polymerase_Homo sapiens_hsa030201.87064670
14Spliceosome_Homo sapiens_hsa030401.86278300
15Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.82141203
16Biosynthesis of amino acids_Homo sapiens_hsa012301.81644595
17Nucleotide excision repair_Homo sapiens_hsa034201.80864853
18Cyanoamino acid metabolism_Homo sapiens_hsa004601.74663366
19Propanoate metabolism_Homo sapiens_hsa006401.69119292
20Cell cycle_Homo sapiens_hsa041101.68614673
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.63291265
22Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.56603205
23Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.42502223
24Fatty acid elongation_Homo sapiens_hsa000621.37612937
25Carbon metabolism_Homo sapiens_hsa012001.36226966
26Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.36034318
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.35211550
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.33987454
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.30424570
30Steroid biosynthesis_Homo sapiens_hsa001001.30334044
31Phagosome_Homo sapiens_hsa041451.23297145
32Pyruvate metabolism_Homo sapiens_hsa006201.23016903
33Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.21904272
34Oocyte meiosis_Homo sapiens_hsa041141.21703879
35Protein export_Homo sapiens_hsa030601.21452049
36Fructose and mannose metabolism_Homo sapiens_hsa000511.16703355
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.10294445
38Fanconi anemia pathway_Homo sapiens_hsa034601.06909411
39Pyrimidine metabolism_Homo sapiens_hsa002401.06881931
40mRNA surveillance pathway_Homo sapiens_hsa030151.06200739
41Base excision repair_Homo sapiens_hsa034101.05932942
42Vitamin B6 metabolism_Homo sapiens_hsa007501.03127492
43RNA degradation_Homo sapiens_hsa030181.01559700
44Nicotine addiction_Homo sapiens_hsa050331.01226026
45Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.99427773
46Oxidative phosphorylation_Homo sapiens_hsa001900.98606376
47Epstein-Barr virus infection_Homo sapiens_hsa051690.97345281
48Fatty acid metabolism_Homo sapiens_hsa012120.90171761
49Arginine and proline metabolism_Homo sapiens_hsa003300.87275427
50Adherens junction_Homo sapiens_hsa045200.87259092
51Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.86768378
52Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.85650222
53Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.84179772
54Type I diabetes mellitus_Homo sapiens_hsa049400.83814401
55Thyroid cancer_Homo sapiens_hsa052160.83813506
56p53 signaling pathway_Homo sapiens_hsa041150.83137161
57Central carbon metabolism in cancer_Homo sapiens_hsa052300.82501481
58Long-term potentiation_Homo sapiens_hsa047200.82501213
59Bladder cancer_Homo sapiens_hsa052190.81597937
60Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.80935310
61Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.80532290
62Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.77772775
63Galactose metabolism_Homo sapiens_hsa000520.77365770
64Arginine biosynthesis_Homo sapiens_hsa002200.76145360
65Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.75473104
66Homologous recombination_Homo sapiens_hsa034400.75422656
67mTOR signaling pathway_Homo sapiens_hsa041500.75224951
68Glutathione metabolism_Homo sapiens_hsa004800.74669197
69Viral carcinogenesis_Homo sapiens_hsa052030.74480705
70Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72594460
71Sulfur metabolism_Homo sapiens_hsa009200.72494444
72N-Glycan biosynthesis_Homo sapiens_hsa005100.72192692
73Pentose phosphate pathway_Homo sapiens_hsa000300.69735303
74Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.68898343
75Basal transcription factors_Homo sapiens_hsa030220.67185151
76Folate biosynthesis_Homo sapiens_hsa007900.66701120
77Legionellosis_Homo sapiens_hsa051340.66415068
78Parkinsons disease_Homo sapiens_hsa050120.66278888
79Non-homologous end-joining_Homo sapiens_hsa034500.65022743
80HIF-1 signaling pathway_Homo sapiens_hsa040660.64190075
81Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.63796935
82Melanoma_Homo sapiens_hsa052180.62410992
83Ribosome_Homo sapiens_hsa030100.62156862
84Dopaminergic synapse_Homo sapiens_hsa047280.61365884
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61108741
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60569831
87Renin-angiotensin system_Homo sapiens_hsa046140.60490664
88Fatty acid degradation_Homo sapiens_hsa000710.59561330
89Purine metabolism_Homo sapiens_hsa002300.57369052
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56426716
91Antigen processing and presentation_Homo sapiens_hsa046120.56413080
92Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.55850210
93Huntingtons disease_Homo sapiens_hsa050160.55326874
94Rheumatoid arthritis_Homo sapiens_hsa053230.54453988
95Colorectal cancer_Homo sapiens_hsa052100.51211281
96beta-Alanine metabolism_Homo sapiens_hsa004100.50953084
97GABAergic synapse_Homo sapiens_hsa047270.49192034
98Gap junction_Homo sapiens_hsa045400.48403542
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47596588
100Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.46329998
101Metabolic pathways_Homo sapiens_hsa011000.44896564
102Selenocompound metabolism_Homo sapiens_hsa004500.43650974
103Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.43601023
104Amphetamine addiction_Homo sapiens_hsa050310.42688314
105Glioma_Homo sapiens_hsa052140.42686870
106Lysine degradation_Homo sapiens_hsa003100.42467932
107TGF-beta signaling pathway_Homo sapiens_hsa043500.41645119
108Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40189690
109Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.38975141
110Long-term depression_Homo sapiens_hsa047300.37245335
111Estrogen signaling pathway_Homo sapiens_hsa049150.36964182
112MicroRNAs in cancer_Homo sapiens_hsa052060.36289841
113Shigellosis_Homo sapiens_hsa051310.35879411
114Fatty acid biosynthesis_Homo sapiens_hsa000610.31183596
115Wnt signaling pathway_Homo sapiens_hsa043100.31162413
116Thyroid hormone synthesis_Homo sapiens_hsa049180.30277532
117Neurotrophin signaling pathway_Homo sapiens_hsa047220.30125207
118Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.30067378
119Hippo signaling pathway_Homo sapiens_hsa043900.29790539
120Endometrial cancer_Homo sapiens_hsa052130.29733397
121ECM-receptor interaction_Homo sapiens_hsa045120.28872687
122Olfactory transduction_Homo sapiens_hsa047400.27779514
123Alzheimers disease_Homo sapiens_hsa050100.25581029
124Glucagon signaling pathway_Homo sapiens_hsa049220.24734758
125Apoptosis_Homo sapiens_hsa042100.24421339
126Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.22806515
127Proteoglycans in cancer_Homo sapiens_hsa052050.22731393
128PI3K-Akt signaling pathway_Homo sapiens_hsa041510.22064591
129Small cell lung cancer_Homo sapiens_hsa052220.21850280
130HTLV-I infection_Homo sapiens_hsa051660.21413903
131Insulin signaling pathway_Homo sapiens_hsa049100.21022800
132Tight junction_Homo sapiens_hsa045300.20674554
133Tyrosine metabolism_Homo sapiens_hsa003500.17766593
134Starch and sucrose metabolism_Homo sapiens_hsa005000.17169042
135Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.15195414
136Prostate cancer_Homo sapiens_hsa052150.14741802
137Peroxisome_Homo sapiens_hsa041460.12637141

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