NARS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a putative member of the class II family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of asparagine to tRNA molecules. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency 24 (COXPD24). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.72784854
2L-phenylalanine catabolic process (GO:0006559)6.72784854
3L-phenylalanine metabolic process (GO:0006558)6.56402336
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.56402336
5aromatic amino acid family catabolic process (GO:0009074)5.93177366
6melanin biosynthetic process (GO:0042438)5.76792167
7indole-containing compound catabolic process (GO:0042436)5.18512919
8indolalkylamine catabolic process (GO:0046218)5.18512919
9tryptophan catabolic process (GO:0006569)5.18512919
10kynurenine metabolic process (GO:0070189)5.18170636
11melanin metabolic process (GO:0006582)5.16880605
12bile acid biosynthetic process (GO:0006699)5.10786939
13secondary metabolite biosynthetic process (GO:0044550)5.07809647
14glyoxylate metabolic process (GO:0046487)5.05111309
15glycine metabolic process (GO:0006544)5.00693156
16tryptophan metabolic process (GO:0006568)4.97043770
17cysteine metabolic process (GO:0006534)4.93917226
18lysine catabolic process (GO:0006554)4.71744596
19lysine metabolic process (GO:0006553)4.71744596
20bile acid metabolic process (GO:0008206)4.51496386
21urea cycle (GO:0000050)4.47168982
22urea metabolic process (GO:0019627)4.47168982
23serine family amino acid catabolic process (GO:0009071)4.47079081
24homocysteine metabolic process (GO:0050667)4.46637224
25aromatic amino acid family metabolic process (GO:0009072)4.43282469
26alpha-linolenic acid metabolic process (GO:0036109)4.42488385
27regulation of protein activation cascade (GO:2000257)4.40946948
28triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.40087467
29serine family amino acid metabolic process (GO:0009069)4.31756519
30protein carboxylation (GO:0018214)4.27276665
31peptidyl-glutamic acid carboxylation (GO:0017187)4.27276665
32sulfur amino acid catabolic process (GO:0000098)4.26777993
33serine family amino acid biosynthetic process (GO:0009070)4.19202786
34alpha-amino acid catabolic process (GO:1901606)4.19003477
35fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.16969695
36regulation of complement activation (GO:0030449)4.14366086
37negative regulation of fibrinolysis (GO:0051918)4.14317413
38regulation of fibrinolysis (GO:0051917)4.10632285
39nitrogen cycle metabolic process (GO:0071941)4.10219104
40imidazole-containing compound metabolic process (GO:0052803)4.06979727
41complement activation, alternative pathway (GO:0006957)4.04683383
42amino-acid betaine metabolic process (GO:0006577)4.01399563
43folic acid-containing compound biosynthetic process (GO:0009396)4.00987685
44high-density lipoprotein particle remodeling (GO:0034375)3.97543522
45tyrosine metabolic process (GO:0006570)3.97164186
46ethanol oxidation (GO:0006069)3.95827005
47coenzyme catabolic process (GO:0009109)3.95230573
48cullin deneddylation (GO:0010388)3.91563659
49proteasome assembly (GO:0043248)3.88907158
50blood coagulation, intrinsic pathway (GO:0007597)3.82987196
51cellular amino acid catabolic process (GO:0009063)3.81723285
52acylglycerol homeostasis (GO:0055090)3.80948226
53triglyceride homeostasis (GO:0070328)3.80948226
54aspartate family amino acid catabolic process (GO:0009068)3.80245287
55indolalkylamine metabolic process (GO:0006586)3.76500293
56short-chain fatty acid metabolic process (GO:0046459)3.74536942
57cellular glucuronidation (GO:0052695)3.69755035
58chromatin remodeling at centromere (GO:0031055)3.68087077
59DNA strand elongation involved in DNA replication (GO:0006271)3.64998491
60CENP-A containing nucleosome assembly (GO:0034080)3.64263340
61one-carbon metabolic process (GO:0006730)3.64184910
62DNA double-strand break processing (GO:0000729)3.63871601
63pteridine-containing compound biosynthetic process (GO:0042559)3.63468888
64acetyl-CoA metabolic process (GO:0006084)3.62962855
65oxaloacetate metabolic process (GO:0006107)3.60377368
66non-recombinational repair (GO:0000726)3.60079366
67double-strand break repair via nonhomologous end joining (GO:0006303)3.60079366
68glutamate metabolic process (GO:0006536)3.57827403
69bile acid and bile salt transport (GO:0015721)3.57520062
70tetrahydrofolate metabolic process (GO:0046653)3.55645796
71benzene-containing compound metabolic process (GO:0042537)3.54520589
72amine catabolic process (GO:0009310)3.53268302
73cellular biogenic amine catabolic process (GO:0042402)3.53268302
74regulation of triglyceride catabolic process (GO:0010896)3.52283141
75protein deneddylation (GO:0000338)3.51127225
76response to nitrosative stress (GO:0051409)3.51036816
77DNA strand elongation (GO:0022616)3.49363345
78cellular ketone body metabolic process (GO:0046950)3.48557637
79transcription from mitochondrial promoter (GO:0006390)3.47178451
80cellular modified amino acid catabolic process (GO:0042219)3.44747071
81ribosome assembly (GO:0042255)3.43341219
82purine nucleobase biosynthetic process (GO:0009113)3.37504077
83valine metabolic process (GO:0006573)3.36497966
84organic acid catabolic process (GO:0016054)3.35624129
85carboxylic acid catabolic process (GO:0046395)3.35624129
86protein-lipid complex remodeling (GO:0034368)3.34780992
87macromolecular complex remodeling (GO:0034367)3.34780992
88plasma lipoprotein particle remodeling (GO:0034369)3.34780992
89cofactor catabolic process (GO:0051187)3.33965516
90aldehyde catabolic process (GO:0046185)3.32875851
91drug transmembrane transport (GO:0006855)3.30366976
92telomere maintenance via semi-conservative replication (GO:0032201)3.30363284
932-oxoglutarate metabolic process (GO:0006103)3.28738735
94negative regulation of sterol transport (GO:0032372)3.28286357
95negative regulation of cholesterol transport (GO:0032375)3.28286357
96dicarboxylic acid biosynthetic process (GO:0043650)3.27699852
97regulation of mitochondrial translation (GO:0070129)3.26528731
98histone exchange (GO:0043486)3.26298105
99reverse cholesterol transport (GO:0043691)3.25955038
100fatty acid beta-oxidation (GO:0006635)3.25094721
101fatty acid oxidation (GO:0019395)3.24838454
102NAD biosynthetic process (GO:0009435)3.24261952
103pyrimidine nucleoside catabolic process (GO:0046135)3.24192173
104cytolysis (GO:0019835)3.22819633
105mitochondrial RNA metabolic process (GO:0000959)3.20021746
106establishment of integrated proviral latency (GO:0075713)3.19552958
107replication fork processing (GO:0031297)3.18883610
108regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.18580022
109pyridine nucleotide biosynthetic process (GO:0019363)3.16527441
110nicotinamide nucleotide biosynthetic process (GO:0019359)3.16527441
111nuclear pore complex assembly (GO:0051292)3.15743828
112lipid oxidation (GO:0034440)3.13039369
113glucuronate metabolic process (GO:0019585)3.12485458
114uronic acid metabolic process (GO:0006063)3.12485458
115DNA ligation (GO:0006266)3.12069832
116nucleobase biosynthetic process (GO:0046112)3.12010149
117fatty acid catabolic process (GO:0009062)3.11618498
118very-low-density lipoprotein particle assembly (GO:0034379)3.11423684
119L-serine metabolic process (GO:0006563)3.11317419
120folic acid metabolic process (GO:0046655)3.11155301
121regulation of bile acid biosynthetic process (GO:0070857)3.10628075
122regulation of cholesterol esterification (GO:0010872)3.10400251
123DNA replication-dependent nucleosome assembly (GO:0006335)3.10012316
124DNA replication-dependent nucleosome organization (GO:0034723)3.10012316
125monocarboxylic acid catabolic process (GO:0072329)3.09610567
126anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.09236423
127sulfur amino acid metabolic process (GO:0000096)3.09180896
128regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.08714348
129regulation of mitotic spindle checkpoint (GO:1903504)3.08714348
130IMP biosynthetic process (GO:0006188)3.08404414
131negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.07691143
132synapsis (GO:0007129)3.06540807
133heme transport (GO:0015886)3.05632250
134disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.05559660
135nuclear pore organization (GO:0006999)3.05307772
136pigment biosynthetic process (GO:0046148)2.99207876
137spindle checkpoint (GO:0031577)2.97441662
138mitotic recombination (GO:0006312)2.96374229
139telomere maintenance via recombination (GO:0000722)2.95153965
140DNA replication checkpoint (GO:0000076)2.94174803
141mitotic sister chromatid segregation (GO:0000070)2.93270129
142mitotic spindle checkpoint (GO:0071174)2.92015175
143positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.90501119
144negative regulation of DNA-dependent DNA replication (GO:2000104)2.90210846
145rRNA modification (GO:0000154)2.88544286
146* tRNA aminoacylation for protein translation (GO:0006418)2.87978027
147* amino acid activation (GO:0043038)2.86988517
148* tRNA aminoacylation (GO:0043039)2.86988517
149sister chromatid segregation (GO:0000819)2.85674886
150regulation of DNA endoreduplication (GO:0032875)2.82745814
151L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.81351119
152DNA replication-independent nucleosome assembly (GO:0006336)2.81236070
153DNA replication-independent nucleosome organization (GO:0034724)2.81236070
154protein localization to kinetochore (GO:0034501)2.81184305
155IMP metabolic process (GO:0046040)2.81177962
156DNA catabolic process, exonucleolytic (GO:0000738)2.77906214
157negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.76780789
158negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.76780789
159negative regulation of mitotic sister chromatid segregation (GO:0033048)2.76780789
160negative regulation of mitotic sister chromatid separation (GO:2000816)2.76780789
161negative regulation of sister chromatid segregation (GO:0033046)2.76780789
162piRNA metabolic process (GO:0034587)2.75947548
163negative regulation of chromosome segregation (GO:0051985)2.75814679
164mitotic nuclear envelope disassembly (GO:0007077)2.75336985
165spliceosomal snRNP assembly (GO:0000387)2.75143535
166respiratory chain complex IV assembly (GO:0008535)2.74543510
167negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.72301268
168negative regulation of ligase activity (GO:0051352)2.72301268
169regulation of cellular amino acid metabolic process (GO:0006521)2.69085311
170nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.68851280
171exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.68687332
172maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.68058258
173mitotic metaphase plate congression (GO:0007080)2.68004914
174pseudouridine synthesis (GO:0001522)2.67949403
175DNA unwinding involved in DNA replication (GO:0006268)2.67813206
176telomere maintenance via telomere lengthening (GO:0010833)2.66257112
177mitotic spindle assembly checkpoint (GO:0007094)2.65191241
178regulation of chromosome segregation (GO:0051983)2.65024083
179nucleotide-excision repair, DNA gap filling (GO:0006297)2.64974679
180viral mRNA export from host cell nucleus (GO:0046784)2.64862595
181signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.63578762
182signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.63578762
183signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.63578762
184rRNA methylation (GO:0031167)2.63284229
185regulation of cofactor metabolic process (GO:0051193)2.62269246
186regulation of coenzyme metabolic process (GO:0051196)2.62269246
187spindle assembly checkpoint (GO:0071173)2.62006134
188DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.61084009
189intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.61052567
190signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.61052567
191regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.60778555
192regulation of mitotic metaphase/anaphase transition (GO:0030071)2.60778555
193regulation of mitotic sister chromatid segregation (GO:0033047)2.58987891
194regulation of sister chromatid segregation (GO:0033045)2.58987891
195regulation of mitotic sister chromatid separation (GO:0010965)2.58987891
196tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.57648847
197RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.57648847
198DNA replication initiation (GO:0006270)2.57627235
199regulation of centriole replication (GO:0046599)2.56508440

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.41711938
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.66474883
3E2F7_22180533_ChIP-Seq_HELA_Human5.20327024
4EGR1_23403033_ChIP-Seq_LIVER_Mouse5.01549719
5PPARA_22158963_ChIP-Seq_LIVER_Mouse4.84486478
6* CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.13233576
7LXR_22158963_ChIP-Seq_LIVER_Mouse3.89801188
8* CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.72307891
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.65966749
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.64774390
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.47315420
12MYC_18555785_ChIP-Seq_MESCs_Mouse3.05577178
13GATA1_22025678_ChIP-Seq_K562_Human2.98385919
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.90504834
15NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.54602479
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.43776602
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.40575604
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.30906386
19* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.15734525
20HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.01569406
21SALL1_21062744_ChIP-ChIP_HESCs_Human1.87971394
22CREB1_15753290_ChIP-ChIP_HEK293T_Human1.87685941
23MYC_19030024_ChIP-ChIP_MESCs_Mouse1.86557568
24PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.85189711
25GABP_17652178_ChIP-ChIP_JURKAT_Human1.80050023
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.76328596
27* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.74635474
28PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73958730
29TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73245196
30ETS1_20019798_ChIP-Seq_JURKAT_Human1.69008232
31ZNF274_21170338_ChIP-Seq_K562_Hela1.68678749
32E2F4_17652178_ChIP-ChIP_JURKAT_Human1.68115291
33* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.66184450
34DCP1A_22483619_ChIP-Seq_HELA_Human1.62862053
35RBPJ_22232070_ChIP-Seq_NCS_Mouse1.62683837
36TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.59151588
37SRF_21415370_ChIP-Seq_HL-1_Mouse1.57550598
38ZFX_18555785_ChIP-Seq_MESCs_Mouse1.55717829
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.54227655
40* FUS_26573619_Chip-Seq_HEK293_Human1.53700731
41VDR_23849224_ChIP-Seq_CD4+_Human1.53553453
42AR_21909140_ChIP-Seq_LNCAP_Human1.50207633
43GABP_19822575_ChIP-Seq_HepG2_Human1.47647494
44FOXP3_21729870_ChIP-Seq_TREG_Human1.47067642
45MYC_19079543_ChIP-ChIP_MESCs_Mouse1.46831990
46EST1_17652178_ChIP-ChIP_JURKAT_Human1.45408947
47DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.45390397
48SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.44853686
49NOTCH1_21737748_ChIP-Seq_TLL_Human1.43526654
50IGF1R_20145208_ChIP-Seq_DFB_Human1.41904441
51POU3F2_20337985_ChIP-ChIP_501MEL_Human1.41610699
52* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.41596383
53HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.39832669
54EWS_26573619_Chip-Seq_HEK293_Human1.38802448
55XRN2_22483619_ChIP-Seq_HELA_Human1.38220471
56E2F1_21310950_ChIP-Seq_MCF-7_Human1.33907155
57ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.33004049
58POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.32829000
59HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.32603577
60MYCN_18555785_ChIP-Seq_MESCs_Mouse1.32045831
61NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.31487421
62HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.27411908
63CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.26981921
64* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.23848370
65HOXB4_20404135_ChIP-ChIP_EML_Mouse1.19777815
66FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.19478787
67ZNF263_19887448_ChIP-Seq_K562_Human1.16913189
68CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.14985688
69* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.13706178
70SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.13623550
71STAT3_1855785_ChIP-Seq_MESCs_Mouse1.08644004
72ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.07600730
73THAP11_20581084_ChIP-Seq_MESCs_Mouse1.06709851
74SOX17_20123909_ChIP-Seq_XEN_Mouse1.05290636
75ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.05089503
76NANOG_16153702_ChIP-ChIP_HESCs_Human1.03966134
77SOX2_16153702_ChIP-ChIP_HESCs_Human1.03914605
78ESR1_15608294_ChIP-ChIP_MCF-7_Human1.03856375
79* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.02191951
80SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.02073058
81E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.01572631
82KDM5A_27292631_Chip-Seq_BREAST_Human1.01539890
83PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01067899
84CIITA_25753668_ChIP-Seq_RAJI_Human1.00658251
85YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99550344
86POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97669311
87FLI1_27457419_Chip-Seq_LIVER_Mouse0.96691720
88VDR_22108803_ChIP-Seq_LS180_Human0.96339496
89RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.96251035
90ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.96234257
91POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.95969913
92TFEB_21752829_ChIP-Seq_HELA_Human0.95547230
93PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95269372
94* HNF4A_19822575_ChIP-Seq_HepG2_Human0.95129229
95NANOG_18555785_ChIP-Seq_MESCs_Mouse0.93966358
96CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.93545675
97FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.93106535
98PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.91047329
99MYC_18940864_ChIP-ChIP_HL60_Human0.90767019
100RXRA_24833708_ChIP-Seq_LIVER_Mouse0.90500266
101ELF1_17652178_ChIP-ChIP_JURKAT_Human0.89880646
102SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.89274431
103YY1_21170310_ChIP-Seq_MESCs_Mouse0.87069561
104HTT_18923047_ChIP-ChIP_STHdh_Human0.86615205
105E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.86541513
106* P300_19829295_ChIP-Seq_ESCs_Human0.86277162
107ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.85659483
108FOXA2_19822575_ChIP-Seq_HepG2_Human0.85276651
109BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.84535778
110CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.83922724
111TTF2_22483619_ChIP-Seq_HELA_Human0.82191744
112CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.80011789
113* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.78297741
114ELK1_19687146_ChIP-ChIP_HELA_Human0.77818010
115EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.77772208
116GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.77704518
117MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.77533714
118FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.77302420
119FOXM1_23109430_ChIP-Seq_U2OS_Human0.75166115
120SOX2_18555785_ChIP-Seq_MESCs_Mouse0.74520216
121* ZFP57_27257070_Chip-Seq_ESCs_Mouse0.74086486
122KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.73704539
123TAF15_26573619_Chip-Seq_HEK293_Human0.72630123
124IRF1_19129219_ChIP-ChIP_H3396_Human0.71792765
125* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.71336967
126MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.70453861
127ELK1_22589737_ChIP-Seq_MCF10A_Human0.69859340
128TP53_22573176_ChIP-Seq_HFKS_Human0.69556822
129CBP_20019798_ChIP-Seq_JUKART_Human0.68848806
130SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.68386035
131* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.67313873
132CLOCK_20551151_ChIP-Seq_293T_Human0.66815970
133* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.66792026
134TBX5_21415370_ChIP-Seq_HL-1_Mouse0.66154804
135RARA_24833708_ChIP-Seq_LIVER_Mouse0.66104900
136KLF4_18555785_ChIP-Seq_MESCs_Mouse0.61760007

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.49681785
2MP0005360_urolithiasis6.53097483
3MP0005085_abnormal_gallbladder_physiolo6.18178076
4MP0000372_irregular_coat_pigmentation6.12624114
5MP0005365_abnormal_bile_salt5.94333391
6MP0003806_abnormal_nucleotide_metabolis5.20623141
7MP0008875_abnormal_xenobiotic_pharmacok4.71558076
8MP0003136_yellow_coat_color4.43938618
9MP0005171_absent_coat_pigmentation3.95071580
10MP0003252_abnormal_bile_duct3.26030072
11MP0010329_abnormal_lipoprotein_level3.01898221
12MP0003195_calcinosis2.88130814
13MP0005083_abnormal_biliary_tract2.82222953
14MP0001666_abnormal_nutrient_absorption2.76292862
15MP0002102_abnormal_ear_morphology2.75128801
16MP0005332_abnormal_amino_acid2.61240493
17MP0003868_abnormal_feces_composition2.59459372
18MP0009697_abnormal_copulation2.41982254
19MP0002938_white_spotting2.31138165
20MP0000015_abnormal_ear_pigmentation2.30069566
21MP0004147_increased_porphyrin_level2.17199098
22MP0008932_abnormal_embryonic_tissue2.15754796
23MP0009840_abnormal_foam_cell2.12134018
24MP0002095_abnormal_skin_pigmentation2.11622392
25MP0001764_abnormal_homeostasis2.05697675
26MP0006292_abnormal_olfactory_placode2.03425867
27MP0000609_abnormal_liver_physiology1.98488183
28MP0002118_abnormal_lipid_homeostasis1.89439511
29MP0006036_abnormal_mitochondrial_physio1.86787227
30MP0001324_abnormal_eye_pigmentation1.84237305
31MP0000371_diluted_coat_color1.81011166
32MP0003656_abnormal_erythrocyte_physiolo1.77640379
33MP0003186_abnormal_redox_activity1.73948118
34MP0003567_abnormal_fetal_cardiomyocyte1.70148556
35MP0005319_abnormal_enzyme/_coenzyme1.68784357
36MP0005220_abnormal_exocrine_pancreas1.68700710
37MP0005584_abnormal_enzyme/coenzyme_acti1.61442344
38MP0008007_abnormal_cellular_replicative1.59993055
39MP0003646_muscle_fatigue1.57266222
40MP0002138_abnormal_hepatobiliary_system1.53296845
41MP0001293_anophthalmia1.52463288
42MP0008789_abnormal_olfactory_epithelium1.51542971
43MP0005174_abnormal_tail_pigmentation1.50704086
44MP0006035_abnormal_mitochondrial_morpho1.41863654
45MP0004381_abnormal_hair_follicle1.38297130
46MP0008057_abnormal_DNA_replication1.38074292
47MP0004019_abnormal_vitamin_homeostasis1.32704525
48MP0009643_abnormal_urine_homeostasis1.30031683
49MP0005266_abnormal_metabolism1.24428757
50MP0000598_abnormal_liver_morphology1.23844022
51MP0005394_taste/olfaction_phenotype1.23557159
52MP0005499_abnormal_olfactory_system1.23557159
53MP0005253_abnormal_eye_physiology1.22655116
54MP0002090_abnormal_vision1.21484973
55MP0002075_abnormal_coat/hair_pigmentati1.21051876
56MP0001984_abnormal_olfaction1.19506028
57MP0003693_abnormal_embryo_hatching1.15498204
58MP0002078_abnormal_glucose_homeostasis1.15147557
59MP0003191_abnormal_cellular_cholesterol1.14438651
60MP0005636_abnormal_mineral_homeostasis1.12676196
61MP0002396_abnormal_hematopoietic_system1.09700895
62MP0009763_increased_sensitivity_to1.09402195
63MP0004264_abnormal_extraembryonic_tissu1.05824208
64MP0010094_abnormal_chromosome_stability1.05640430
65MP0001929_abnormal_gametogenesis1.05474455
66MP0006072_abnormal_retinal_apoptosis1.05371144
67MP0009765_abnormal_xenobiotic_induced1.04564405
68MP0001186_pigmentation_phenotype1.02889082
69MP0003878_abnormal_ear_physiology1.02850955
70MP0005377_hearing/vestibular/ear_phenot1.02850955
71MP0003890_abnormal_embryonic-extraembry1.02534573
72MP0004043_abnormal_pH_regulation0.99151081
73MP0002234_abnormal_pharynx_morphology0.98690671
74MP0003121_genomic_imprinting0.98143142
75MP0002638_abnormal_pupillary_reflex0.95999821
76MP0001697_abnormal_embryo_size0.95204285
77MP0004233_abnormal_muscle_weight0.93983864
78MP0001661_extended_life_span0.93871196
79MP0003786_premature_aging0.93199728
80MP0005376_homeostasis/metabolism_phenot0.92995208
81MP0002210_abnormal_sex_determination0.92338500
82MP0005248_abnormal_Harderian_gland0.91446067
83MP0001672_abnormal_embryogenesis/_devel0.89958588
84MP0005380_embryogenesis_phenotype0.89958588
85MP0002160_abnormal_reproductive_system0.89454153
86MP0000569_abnormal_digit_pigmentation0.89189667
87MP0009672_abnormal_birth_weight0.88852477
88MP0005187_abnormal_penis_morphology0.87773934
89MP0005391_vision/eye_phenotype0.87271120
90MP0001944_abnormal_pancreas_morphology0.86762167
91MP0002084_abnormal_developmental_patter0.84979808
92MP0010030_abnormal_orbit_morphology0.83612980
93MP0003937_abnormal_limbs/digits/tail_de0.83054768
94MP0000350_abnormal_cell_proliferation0.82292262
95MP0009642_abnormal_blood_homeostasis0.81080180
96MP0003941_abnormal_skin_development0.81066757
97MP0003123_paternal_imprinting0.79861061
98MP0000653_abnormal_sex_gland0.79729943
99MP0002693_abnormal_pancreas_physiology0.78772648
100MP0002233_abnormal_nose_morphology0.78421528
101MP0002085_abnormal_embryonic_tissue0.78082502
102MP0001145_abnormal_male_reproductive0.77732206
103MP0000647_abnormal_sebaceous_gland0.77467009
104MP0004197_abnormal_fetal_growth/weight/0.76826849
105MP0003698_abnormal_male_reproductive0.76519906
106MP0002877_abnormal_melanocyte_morpholog0.75948101
107MP0002080_prenatal_lethality0.75357908
108MP0005647_abnormal_sex_gland0.75081812
109MP0005535_abnormal_body_temperature0.74889175
110MP0005551_abnormal_eye_electrophysiolog0.72430238
111MP0002697_abnormal_eye_size0.71718689
112MP0005084_abnormal_gallbladder_morpholo0.71146467
113MP0008995_early_reproductive_senescence0.70158633
114MP0000358_abnormal_cell_content/0.69780731
115MP0005670_abnormal_white_adipose0.69576417
116MP0002822_catalepsy0.68914044
117MP0005334_abnormal_fat_pad0.68675147
118MP0008469_abnormal_protein_level0.68232748
119MP0001286_abnormal_eye_development0.68144916
120MP0005257_abnormal_intraocular_pressure0.68041570
121MP0002751_abnormal_autonomic_nervous0.67533304
122MP0003984_embryonic_growth_retardation0.67162592
123MP0009764_decreased_sensitivity_to0.67049655
124MP0002088_abnormal_embryonic_growth/wei0.66100080
125MP0003111_abnormal_nucleus_morphology0.65564987
126MP0004133_heterotaxia0.65327252
127MP0008872_abnormal_physiological_respon0.64663814
128MP0005408_hypopigmentation0.63754303
129MP0000631_abnormal_neuroendocrine_gland0.63135248
130MP0002092_abnormal_eye_morphology0.62785202
131MP0002971_abnormal_brown_adipose0.62015700
132MP0003943_abnormal_hepatobiliary_system0.61956598
133MP0008058_abnormal_DNA_repair0.61124979
134MP0004957_abnormal_blastocyst_morpholog0.61031892
135MP0003718_maternal_effect0.60376106
136MP0005197_abnormal_uvea_morphology0.59988715
137MP0001756_abnormal_urination0.59276138
138MP0001529_abnormal_vocalization0.59022341
139MP0008873_increased_physiological_sensi0.58602167
140MP0002837_dystrophic_cardiac_calcinosis0.57622335
141MP0003122_maternal_imprinting0.56762237
142MP0002970_abnormal_white_adipose0.50552303
143MP0002876_abnormal_thyroid_physiology0.50344599
144MP0003221_abnormal_cardiomyocyte_apopto0.49965740
145MP0000639_abnormal_adrenal_gland0.49588230
146MP0005448_abnormal_energy_balance0.48961335
147MP0003953_abnormal_hormone_level0.48491477
148MP0002269_muscular_atrophy0.46437623
149MP0010352_gastrointestinal_tract_polyps0.45270691
150MP0008877_abnormal_DNA_methylation0.41339322
151MP0001730_embryonic_growth_arrest0.41218559
152MP0003077_abnormal_cell_cycle0.40810084
153MP0003172_abnormal_lysosome_physiology0.37898884
154MP0009379_abnormal_foot_pigmentation0.37389396
155MP0003300_gastrointestinal_ulcer0.34704211
156MP0005452_abnormal_adipose_tissue0.33852856
157MP0000747_muscle_weakness0.32315246
158MP0000013_abnormal_adipose_tissue0.31243087
159MP0001545_abnormal_hematopoietic_system0.31015518
160MP0005397_hematopoietic_system_phenotyp0.31015518
161MP0010368_abnormal_lymphatic_system0.30753856
162MP0002136_abnormal_kidney_physiology0.30115753
163MP0003638_abnormal_response/metabolism_0.30115440
164MP0005075_abnormal_melanosome_morpholog0.30094506
165MP0002019_abnormal_tumor_incidence0.27941672
166MP0000230_abnormal_systemic_arterial0.27768781
167MP0005666_abnormal_adipose_tissue0.27328206
168MP0002928_abnormal_bile_duct0.27278767
169MP0004130_abnormal_muscle_cell0.26602781
170MP0009703_decreased_birth_body0.25574484
171MP0005330_cardiomyopathy0.25547597

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)6.64977179
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.53474488
3Hypobetalipoproteinemia (HP:0003563)5.50674252
4Abnormality of monocarboxylic acid metabolism (HP:0010996)5.46979030
5Prolonged partial thromboplastin time (HP:0003645)5.38247561
6Deep venous thrombosis (HP:0002625)4.92064946
7Xanthomatosis (HP:0000991)4.71116524
8Hypoglycemic coma (HP:0001325)4.58448110
9Hyperammonemia (HP:0001987)4.37665973
10Hyperglycinemia (HP:0002154)4.30596748
11Ketosis (HP:0001946)4.20637646
12Abnormality of methionine metabolism (HP:0010901)4.10566859
13Hyperlipoproteinemia (HP:0010980)4.02144695
14Hypolipoproteinemia (HP:0010981)4.02131843
15Hypoplasia of the fovea (HP:0007750)3.91377904
16Aplasia/Hypoplasia of the fovea (HP:0008060)3.91377904
17Aplasia/Hypoplasia of the macula (HP:0008059)3.85951135
18Abnormality of sulfur amino acid metabolism (HP:0004339)3.83625069
19Epidermoid cyst (HP:0200040)3.73127927
20Abnormality of aspartate family amino acid metabolism (HP:0010899)3.67658562
21Abnormality of the common coagulation pathway (HP:0010990)3.63809561
22Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.60278490
23Chromosomal breakage induced by crosslinking agents (HP:0003221)3.58436411
24Patchy hypopigmentation of hair (HP:0011365)3.57402259
25Chromsome breakage (HP:0040012)3.55173444
26Aplasia/Hypoplasia affecting the retina (HP:0008061)3.53978903
27Ketoacidosis (HP:0001993)3.53472317
28Complement deficiency (HP:0004431)3.50594325
29White forelock (HP:0002211)3.49536361
30Abnormality of serine family amino acid metabolism (HP:0010894)3.45439805
31Abnormality of glycine metabolism (HP:0010895)3.45439805
32Abnormality of the fovea (HP:0000493)3.45379489
33Abnormality of the intrinsic pathway (HP:0010989)3.43747147
34Fat malabsorption (HP:0002630)3.43706700
35Joint hemorrhage (HP:0005261)3.42886839
36Abnormality of pyrimidine metabolism (HP:0004353)3.42738688
37Abnormality of serum amino acid levels (HP:0003112)3.41899930
38Acanthocytosis (HP:0001927)3.31507839
39Hyperglycinuria (HP:0003108)3.28988284
40Hypoalphalipoproteinemia (HP:0003233)3.28208229
41Cerebral edema (HP:0002181)3.21232357
42Hyperbilirubinemia (HP:0002904)3.20967550
43Conjugated hyperbilirubinemia (HP:0002908)3.17652898
44Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.11002427
45Hypoglycemic seizures (HP:0002173)3.09431369
46Abnormality of fatty-acid metabolism (HP:0004359)3.06806150
47Metabolic acidosis (HP:0001942)3.01438750
48Abnormality of glutamine family amino acid metabolism (HP:0010902)3.00017698
49Dicarboxylic aciduria (HP:0003215)2.96853722
50Abnormality of dicarboxylic acid metabolism (HP:0010995)2.96853722
51Hypochromic microcytic anemia (HP:0004840)2.93493343
52Acute necrotizing encephalopathy (HP:0006965)2.93121965
53Meckel diverticulum (HP:0002245)2.90589655
54Hepatic necrosis (HP:0002605)2.88080898
55Delayed CNS myelination (HP:0002188)2.86249482
56Lethargy (HP:0001254)2.81404815
57Abnormality of the ileum (HP:0001549)2.79498892
58Aplasia/Hypoplasia of the uvula (HP:0010293)2.77434704
59Abnormality of chromosome stability (HP:0003220)2.73451949
60Blue irides (HP:0000635)2.72268222
61Abnormality of the labia minora (HP:0012880)2.65762595
62Hyperinsulinemic hypoglycemia (HP:0000825)2.63242226
63Abnormality of the heme biosynthetic pathway (HP:0010472)2.59345454
64Hypercholesterolemia (HP:0003124)2.58941650
65Generalized aminoaciduria (HP:0002909)2.53508394
66Ragged-red muscle fibers (HP:0003200)2.52366943
67Abnormality of nucleobase metabolism (HP:0010932)2.52155159
68Progressive macrocephaly (HP:0004481)2.50716100
69Abnormality of complement system (HP:0005339)2.50680138
70Hepatocellular carcinoma (HP:0001402)2.49842264
71Acute encephalopathy (HP:0006846)2.48985855
72Intestinal atresia (HP:0011100)2.48398874
73Abnormality of the anterior horn cell (HP:0006802)2.47336200
74Degeneration of anterior horn cells (HP:0002398)2.47336200
75Steatorrhea (HP:0002570)2.46949782
76Abnormal lung lobation (HP:0002101)2.46094841
77Hepatocellular necrosis (HP:0001404)2.45369882
78Type I transferrin isoform profile (HP:0003642)2.42767006
79Poikilocytosis (HP:0004447)2.42159253
80Abnormality of the preputium (HP:0100587)2.41328905
81Cutaneous melanoma (HP:0012056)2.39144378
82Ocular albinism (HP:0001107)2.39065733
83Abnormal auditory evoked potentials (HP:0006958)2.37957742
84Iris hypopigmentation (HP:0007730)2.37829429
85Increased hepatocellular lipid droplets (HP:0006565)2.35268419
86Hypopigmentation of the fundus (HP:0007894)2.34652281
87Reduced antithrombin III activity (HP:0001976)2.33656078
88Abnormality of the pancreatic islet cells (HP:0006476)2.33108588
89Abnormality of endocrine pancreas physiology (HP:0012093)2.33108588
90Nephroblastoma (Wilms tumor) (HP:0002667)2.32607103
91Brushfield spots (HP:0001088)2.31555539
92Lactic acidosis (HP:0003128)2.30015383
93Renal cortical cysts (HP:0000803)2.27961051
94Colon cancer (HP:0003003)2.26291687
95Generalized hypopigmentation (HP:0007513)2.25318565
96Abnormality of glycolysis (HP:0004366)2.24607130
97Increased serum pyruvate (HP:0003542)2.24607130
98Acute hepatic failure (HP:0006554)2.20450879
99Hyperglycemia (HP:0003074)2.19252619
100Cholecystitis (HP:0001082)2.18029487
101Abnormal gallbladder physiology (HP:0012438)2.18029487
102Spastic diplegia (HP:0001264)2.17649410
103Embryonal renal neoplasm (HP:0011794)2.17566487
104Progressive inability to walk (HP:0002505)2.14165195
105Small intestinal stenosis (HP:0012848)2.12221597
106Duodenal stenosis (HP:0100867)2.12221597
107Increased serum lactate (HP:0002151)2.11421343
108Opisthotonus (HP:0002179)2.11221845
109Abnormal gallbladder morphology (HP:0012437)2.09531717
110Vomiting (HP:0002013)2.09428687
111Abnormality of alanine metabolism (HP:0010916)2.08496465
112Hyperalaninemia (HP:0003348)2.08496465
113Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.08496465
114Skin nodule (HP:0200036)2.07997850
115Facial cleft (HP:0002006)2.06872800
116Abnormality of purine metabolism (HP:0004352)2.06863395
117Increased muscle lipid content (HP:0009058)2.05452090
118Gonadotropin excess (HP:0000837)2.04754702
119Increased CSF lactate (HP:0002490)2.04227343
120Abnormality of the duodenum (HP:0002246)2.04110854
121Ependymoma (HP:0002888)2.03427863
122Methylmalonic acidemia (HP:0002912)2.03339779
123Biliary tract neoplasm (HP:0100574)2.02541699
124Abnormal mitochondria in muscle tissue (HP:0008316)2.01540493
125Hypoplasia of the thymus (HP:0000778)2.01149007
126Abnormal protein glycosylation (HP:0012346)2.00887990
127Abnormal glycosylation (HP:0012345)2.00887990
128Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.00887990
129Abnormal protein N-linked glycosylation (HP:0012347)2.00887990
130Megaloblastic anemia (HP:0001889)2.00820868
131Pancreatitis (HP:0001733)1.99778943
132Cholelithiasis (HP:0001081)1.98148248
133Late onset (HP:0003584)1.97447329
134Microvesicular hepatic steatosis (HP:0001414)1.97264645
135Symptomatic seizures (HP:0011145)1.96631906
136Volvulus (HP:0002580)1.95831231
137Pancreatic islet-cell hyperplasia (HP:0004510)1.95608786
138Abnormality of iron homeostasis (HP:0011031)1.95008678
139Abnormality of vitamin metabolism (HP:0100508)1.93702880
140Lipid accumulation in hepatocytes (HP:0006561)1.93479019
141Freckling (HP:0001480)1.92819697
142Sloping forehead (HP:0000340)1.92802951
143Bifid tongue (HP:0010297)1.92590052
144Methylmalonic aciduria (HP:0012120)1.91695129
145Mitochondrial inheritance (HP:0001427)1.90796941
146Neoplasm of the rectum (HP:0100743)1.90789498
147Enlarged kidneys (HP:0000105)1.90205533
148Abnormality of transition element cation homeostasis (HP:0011030)1.89244222
149Gout (HP:0001997)1.89061177
150Neoplasm of the adrenal gland (HP:0100631)1.88761504
151Carpal bone hypoplasia (HP:0001498)1.88514136
152Tubulointerstitial nephritis (HP:0001970)1.88097526
153Astigmatism (HP:0000483)1.84449799
154Medial flaring of the eyebrow (HP:0010747)1.79992255
155Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.79532425
156Horseshoe kidney (HP:0000085)1.79258480
157Birth length less than 3rd percentile (HP:0003561)1.75640037
158Multiple enchondromatosis (HP:0005701)1.73319749
159Abnormal biliary tract physiology (HP:0012439)1.70829889
160Bile duct proliferation (HP:0001408)1.70829889
161Exercise intolerance (HP:0003546)1.70209189
162Supernumerary spleens (HP:0009799)1.69204816
163Respiratory failure (HP:0002878)1.68279991
164Congenital stationary night blindness (HP:0007642)1.67890682
165Exercise-induced muscle cramps (HP:0003710)1.67648796

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.30301959
2INSRR3.89345211
3EIF2AK33.69724177
4ACVR1B3.35644322
5FLT33.32304862
6TRIM282.85204197
7BUB12.78720525
8TAOK32.74487569
9STK162.59950105
10CDC72.52960864
11SCYL22.45476020
12PKN22.42574826
13PLK32.35885168
14WEE12.35448044
15PASK2.27008625
16EIF2AK12.21424994
17NME22.07489049
18BMPR1B2.02985221
19PDK21.97275251
20VRK21.92055719
21MKNK11.84764734
22NEK11.76203921
23PLK41.66212926
24CAMK1D1.64457258
25ZAK1.63600043
26TLK11.58939344
27MKNK21.54395185
28PLK21.54180771
29TTK1.53280260
30WNK31.49658483
31BCR1.44545514
32MAPK111.44253179
33BRSK21.42713123
34FGFR41.42072469
35CSNK1A1L1.39924437
36ERBB31.38723490
37VRK11.30799688
38MST1R1.30579054
39MAP2K41.29100609
40CSNK1G21.27594293
41ERBB41.26677187
42ATR1.25511713
43DYRK31.22311816
44TYK21.20180043
45CDK191.17148411
46MST41.11856749
47CDK41.09489844
48CAMKK21.09081817
49HIPK21.08967348
50TSSK61.03900517
51FRK1.03782257
52NEK21.03560465
53MAP3K21.01704017
54ERN11.00570258
55MAP4K20.98888070
56KDR0.97776407
57SRPK10.97149299
58CCNB10.93638316
59SIK10.93321441
60EIF2AK20.90808862
61PINK10.89391587
62STK30.87899421
63PIK3CG0.87240449
64WNK40.84745109
65CDK60.84337513
66AURKA0.80804950
67AURKB0.79769680
68MAP3K130.79416933
69TAF10.78420077
70MAP2K20.78111070
71NEK90.75180178
72MARK30.73974988
73MAP3K110.72503558
74MAP3K40.71747127
75MAP3K100.70111343
76PLK10.70020981
77STK390.69527261
78OBSCN0.69417884
79FGFR20.69059382
80BRSK10.68950829
81MAP3K50.68658424
82PBK0.67080223
83CSNK2A20.67009645
84PRKAA10.66951300
85TGFBR10.65066593
86RPS6KB20.64621433
87CAMK1G0.63502989
88MAP3K70.62775294
89BRAF0.62438616
90MAP3K80.61678359
91PNCK0.60126083
92MAP2K30.58151760
93ABL20.57138347
94PRKAA20.56910226
95STK40.56753674
96RPS6KB10.56665555
97TEC0.55517704
98ATM0.54001591
99OXSR10.53982099
100RPS6KA40.52893344
101MAP2K10.51708053
102CHEK20.51642585
103PDK30.51341071
104PDK40.51341071
105MET0.50484260
106NUAK10.50423234
107LATS10.50257916
108GRK10.48719198
109CAMK2G0.48399577
110DAPK10.48051970
111AKT20.47852353
112FGFR10.47533634
113FER0.47097834
114STK38L0.46267871
115BTK0.46119508
116JAK20.45657668
117IRAK10.45219948
118MAP3K30.44073752
119CSNK1G30.43962161
120CDK30.43028117
121LRRK20.42045738
122CSNK1D0.41099162
123NEK60.39244489
124CSNK1G10.38768462
125CSNK1A10.38405313
126CDK20.37760943
127CSNK2A10.37633735
128CHEK10.37577559
129DYRK20.37503261
130CDK70.37053379
131PRKACG0.36204474
132PRKDC0.34964706
133MAP2K70.34117821
134ERBB20.33839748
135CSNK1E0.33603889
136RPS6KA50.33194149
137CLK10.32990187
138TNIK0.32955080
139TAOK20.32315400
140BRD40.31710892
141MAPK130.30826979
142PRKCG0.30036399
143DYRK1B0.29881281
144CDK10.29645791
145NME10.28695231
146MAPKAPK50.26114770
147ADRBK20.26002462

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.02946949
2Non-homologous end-joining_Homo sapiens_hsa034503.22655142
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.02137655
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.90851349
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.81505372
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.44865220
7Arginine biosynthesis_Homo sapiens_hsa002202.38728203
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.36703445
9Selenocompound metabolism_Homo sapiens_hsa004502.36520371
10Fatty acid degradation_Homo sapiens_hsa000712.35894811
11Tryptophan metabolism_Homo sapiens_hsa003802.33809630
12Nitrogen metabolism_Homo sapiens_hsa009102.30599561
13Drug metabolism - other enzymes_Homo sapiens_hsa009832.15296839
14Propanoate metabolism_Homo sapiens_hsa006402.11527881
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.08120643
16Butanoate metabolism_Homo sapiens_hsa006502.06223155
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.04457991
18Peroxisome_Homo sapiens_hsa041462.01660913
19One carbon pool by folate_Homo sapiens_hsa006701.99600727
20Fanconi anemia pathway_Homo sapiens_hsa034601.97653669
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.95115195
22Complement and coagulation cascades_Homo sapiens_hsa046101.92924227
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.80418167
24Folate biosynthesis_Homo sapiens_hsa007901.79216269
25Pentose and glucuronate interconversions_Homo sapiens_hsa000401.78981313
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.77375433
27Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.74679448
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.71579180
29Spliceosome_Homo sapiens_hsa030401.71077741
30Pyruvate metabolism_Homo sapiens_hsa006201.70708833
31RNA degradation_Homo sapiens_hsa030181.68192133
32Sulfur metabolism_Homo sapiens_hsa009201.66819628
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.61237458
34Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.59358857
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.58778083
36Cell cycle_Homo sapiens_hsa041101.57997457
37Basal transcription factors_Homo sapiens_hsa030221.55852027
38beta-Alanine metabolism_Homo sapiens_hsa004101.55503553
39Fatty acid metabolism_Homo sapiens_hsa012121.54763713
40Mismatch repair_Homo sapiens_hsa034301.52266888
41Caffeine metabolism_Homo sapiens_hsa002321.52138643
42Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.49129241
43Biosynthesis of amino acids_Homo sapiens_hsa012301.45262640
44Carbon metabolism_Homo sapiens_hsa012001.44500484
45Chemical carcinogenesis_Homo sapiens_hsa052041.42194387
46Sulfur relay system_Homo sapiens_hsa041221.41236941
47Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.40868533
48Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.37950530
49Phenylalanine metabolism_Homo sapiens_hsa003601.37240564
50Histidine metabolism_Homo sapiens_hsa003401.34651749
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.29619503
52Fatty acid elongation_Homo sapiens_hsa000621.27891865
53Tyrosine metabolism_Homo sapiens_hsa003501.27266555
54Retinol metabolism_Homo sapiens_hsa008301.25743994
55Starch and sucrose metabolism_Homo sapiens_hsa005001.25643362
56ABC transporters_Homo sapiens_hsa020101.22671874
57PPAR signaling pathway_Homo sapiens_hsa033201.21895443
58DNA replication_Homo sapiens_hsa030301.20826190
59mRNA surveillance pathway_Homo sapiens_hsa030151.16745946
60Huntingtons disease_Homo sapiens_hsa050161.13921872
61Bile secretion_Homo sapiens_hsa049761.03843554
62Cyanoamino acid metabolism_Homo sapiens_hsa004601.02381099
63Steroid biosynthesis_Homo sapiens_hsa001001.02172739
64Fat digestion and absorption_Homo sapiens_hsa049751.01123330
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.98012391
66* Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.95358346
67Arginine and proline metabolism_Homo sapiens_hsa003300.92177173
68Oocyte meiosis_Homo sapiens_hsa041140.85389050
69Pyrimidine metabolism_Homo sapiens_hsa002400.84851015
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84815846
71Protein export_Homo sapiens_hsa030600.78683580
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77056583
73Pentose phosphate pathway_Homo sapiens_hsa000300.76910887
74Vitamin B6 metabolism_Homo sapiens_hsa007500.76540024
75Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75692232
76Lysine degradation_Homo sapiens_hsa003100.74187840
77p53 signaling pathway_Homo sapiens_hsa041150.74146958
78Metabolic pathways_Homo sapiens_hsa011000.70353406
79Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.67991528
80Vitamin digestion and absorption_Homo sapiens_hsa049770.66127856
81Glutathione metabolism_Homo sapiens_hsa004800.60167126
82Staphylococcus aureus infection_Homo sapiens_hsa051500.57875029
83Galactose metabolism_Homo sapiens_hsa000520.52094604
84Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.51414905
85Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.50772751
86Glycerolipid metabolism_Homo sapiens_hsa005610.50125803
87Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48147727
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44398148
89Oxidative phosphorylation_Homo sapiens_hsa001900.43935507
90Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.43197522
91Proteasome_Homo sapiens_hsa030500.41055731
92Phototransduction_Homo sapiens_hsa047440.41006343
93Parkinsons disease_Homo sapiens_hsa050120.40435238
94Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39422684
95Systemic lupus erythematosus_Homo sapiens_hsa053220.36732112
96Regulation of autophagy_Homo sapiens_hsa041400.34204523
97Homologous recombination_Homo sapiens_hsa034400.33243019
98RNA polymerase_Homo sapiens_hsa030200.31862817
99Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.29395292
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.27444616
101Glucagon signaling pathway_Homo sapiens_hsa049220.25659631
102Fructose and mannose metabolism_Homo sapiens_hsa000510.23660162
103Purine metabolism_Homo sapiens_hsa002300.22872267
104N-Glycan biosynthesis_Homo sapiens_hsa005100.22792252
105Alcoholism_Homo sapiens_hsa050340.22555245
106Nucleotide excision repair_Homo sapiens_hsa034200.22436419
107Linoleic acid metabolism_Homo sapiens_hsa005910.21681986
108Insulin resistance_Homo sapiens_hsa049310.21186137
109RNA transport_Homo sapiens_hsa030130.18565170
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.18165055
111Ribosome_Homo sapiens_hsa030100.17411020
112alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.16476131
113Cardiac muscle contraction_Homo sapiens_hsa042600.16194918
114Base excision repair_Homo sapiens_hsa034100.15437152
115Alzheimers disease_Homo sapiens_hsa050100.14367544
116Prion diseases_Homo sapiens_hsa050200.13957235
117Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.12488013
118Fatty acid biosynthesis_Homo sapiens_hsa000610.09874687

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »