NASP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a H1 histone binding protein that is involved in transporting histones into the nucleus of dividing cells. Multiple isoforms are encoded by transcript variants of this gene. The somatic form is expressed in all mitotic cells, is localized to the nucleus, and is coupled to the cell cycle. The testicular form is expressed in embryonic tissues, tumor cells, and the testis. In male germ cells, this protein is localized to the cytoplasm of primary spermatocytes, the nucleus of spermatids, and the periacrosomal region of mature spermatozoa. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)5.10857407
2nuclear pore complex assembly (GO:0051292)4.97197042
3DNA unwinding involved in DNA replication (GO:0006268)4.68297051
4mitotic metaphase plate congression (GO:0007080)4.47366377
5DNA replication initiation (GO:0006270)4.32923770
6protein localization to kinetochore (GO:0034501)4.30944695
7DNA strand elongation involved in DNA replication (GO:0006271)4.12145215
8kinetochore organization (GO:0051383)4.10569659
9DNA topological change (GO:0006265)4.06378468
10DNA ligation (GO:0006266)4.04373044
11metaphase plate congression (GO:0051310)4.04137344
12mitotic sister chromatid cohesion (GO:0007064)4.01161440
13mitotic nuclear envelope disassembly (GO:0007077)3.98918757
14DNA replication checkpoint (GO:0000076)3.96844590
15chromatin remodeling at centromere (GO:0031055)3.93078155
16protein localization to chromosome, centromeric region (GO:0071459)3.91998376
17DNA strand elongation (GO:0022616)3.91451235
18establishment of viral latency (GO:0019043)3.89086063
19regulation of centriole replication (GO:0046599)3.87708978
20negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.83713329
21pore complex assembly (GO:0046931)3.79040841
22CENP-A containing nucleosome assembly (GO:0034080)3.78613841
23mitotic sister chromatid segregation (GO:0000070)3.73239774
24pre-miRNA processing (GO:0031054)3.71849016
25nuclear envelope disassembly (GO:0051081)3.70936301
26membrane disassembly (GO:0030397)3.70936301
27mitotic chromosome condensation (GO:0007076)3.69609756
28negative regulation of DNA-dependent DNA replication (GO:2000104)3.67728252
29negative regulation of mRNA processing (GO:0050686)3.65521993
30regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.64489600
31kinetochore assembly (GO:0051382)3.62765466
32telomere maintenance via semi-conservative replication (GO:0032201)3.62077406
33nucleobase biosynthetic process (GO:0046112)3.61402028
34sister chromatid segregation (GO:0000819)3.59502899
35regulation of DNA endoreduplication (GO:0032875)3.58277684
36regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.58268410
37regulation of centrosome cycle (GO:0046605)3.54820573
38regulation of posttranscriptional gene silencing (GO:0060147)3.54715365
39regulation of gene silencing by miRNA (GO:0060964)3.54715365
40regulation of gene silencing by RNA (GO:0060966)3.54715365
41* DNA replication-dependent nucleosome assembly (GO:0006335)3.53920953
42* DNA replication-dependent nucleosome organization (GO:0034723)3.53920953
43ribosome assembly (GO:0042255)3.53185695
44regulation of histone H3-K9 methylation (GO:0051570)3.51934386
45attachment of spindle microtubules to kinetochore (GO:0008608)3.50766593
46microtubule depolymerization (GO:0007019)3.49972660
47* histone exchange (GO:0043486)3.49693629
48non-recombinational repair (GO:0000726)3.49226338
49double-strand break repair via nonhomologous end joining (GO:0006303)3.49226338
50mitotic recombination (GO:0006312)3.48130757
51establishment of chromosome localization (GO:0051303)3.47702385
52L-serine metabolic process (GO:0006563)3.45169062
53heterochromatin organization (GO:0070828)3.44178659
54* DNA replication-independent nucleosome organization (GO:0034724)3.43967125
55* DNA replication-independent nucleosome assembly (GO:0006336)3.43967125
56telomere maintenance via recombination (GO:0000722)3.42912588
57positive regulation of chromosome segregation (GO:0051984)3.42753769
58negative regulation of mRNA metabolic process (GO:1903312)3.41391132
59regulation of helicase activity (GO:0051095)3.40665624
60purine nucleobase biosynthetic process (GO:0009113)3.40012340
61regulation of spindle organization (GO:0090224)3.39826765
62negative regulation of RNA splicing (GO:0033119)3.39782210
63DNA geometric change (GO:0032392)3.39376627
64regulation of chromosome segregation (GO:0051983)3.38765967
65DNA duplex unwinding (GO:0032508)3.38631964
66regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.35883878
67replication fork processing (GO:0031297)3.34975891
68protein K6-linked ubiquitination (GO:0085020)3.34634855
69IMP metabolic process (GO:0046040)3.29818082
70paraxial mesoderm development (GO:0048339)3.29772624
71spindle checkpoint (GO:0031577)3.28259186
72meiotic chromosome segregation (GO:0045132)3.27910142
73negative regulation of chromosome segregation (GO:0051985)3.27415248
74formation of translation preinitiation complex (GO:0001731)3.26788235
75somatic hypermutation of immunoglobulin genes (GO:0016446)3.23360659
76somatic diversification of immune receptors via somatic mutation (GO:0002566)3.23360659
77negative regulation of mitotic sister chromatid separation (GO:2000816)3.23281490
78negative regulation of mitotic sister chromatid segregation (GO:0033048)3.23281490
79negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.23281490
80negative regulation of sister chromatid segregation (GO:0033046)3.23281490
81DNA damage response, detection of DNA damage (GO:0042769)3.23205532
82regulation of mitotic metaphase/anaphase transition (GO:0030071)3.23174007
83regulation of mitotic spindle checkpoint (GO:1903504)3.22809011
84regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.22809011
85regulation of sister chromatid cohesion (GO:0007063)3.22421087
86mitotic spindle checkpoint (GO:0071174)3.16735405
87spindle assembly checkpoint (GO:0071173)3.16349162
88regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.16070876
89regulation of RNA export from nucleus (GO:0046831)3.16059418
90IMP biosynthetic process (GO:0006188)3.14411242
91maturation of SSU-rRNA (GO:0030490)3.14286094
92negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.14086042
93telomere maintenance via telomere lengthening (GO:0010833)3.12445135
94mitotic spindle assembly checkpoint (GO:0007094)3.11752412
95maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.11562037
96DNA strand renaturation (GO:0000733)3.11172973
97positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.11049072
98positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.11049072
99positive regulation of mitotic sister chromatid separation (GO:1901970)3.11049072
100protein complex localization (GO:0031503)3.09894321
101DNA double-strand break processing (GO:0000729)3.08666873
102piRNA metabolic process (GO:0034587)3.08546416
103* ATP-dependent chromatin remodeling (GO:0043044)3.08352130
104regulation of mitotic sister chromatid separation (GO:0010965)3.08125032
105regulation of mitotic sister chromatid segregation (GO:0033047)3.08125032
106regulation of sister chromatid segregation (GO:0033045)3.08125032
107protein localization to chromosome (GO:0034502)3.07027634
108nucleotide-excision repair, DNA gap filling (GO:0006297)3.06827818
109* chromatin assembly or disassembly (GO:0006333)3.04496559
110mismatch repair (GO:0006298)3.03560428
111negative regulation of histone methylation (GO:0031061)3.02013935
112DNA conformation change (GO:0071103)3.01796661
113intra-S DNA damage checkpoint (GO:0031573)3.00389210
114regulation of nuclear cell cycle DNA replication (GO:0033262)3.00386813
115spliceosomal snRNP assembly (GO:0000387)3.00175160
116chromosome segregation (GO:0007059)2.99838593
117termination of RNA polymerase II transcription (GO:0006369)2.99633336
118ribosome biogenesis (GO:0042254)2.99515286
119chromosome condensation (GO:0030261)2.98381780
120regulation of mitotic spindle organization (GO:0060236)2.97336692
121establishment of integrated proviral latency (GO:0075713)2.96350128
122synaptonemal complex assembly (GO:0007130)2.95020946
123mRNA splicing, via spliceosome (GO:0000398)2.94097969
124RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.94097969
125synapsis (GO:0007129)2.91767330
126RNA splicing, via transesterification reactions (GO:0000375)2.91325012

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.20978403
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.41580577
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.11807112
4MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.01885275
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.64339289
6* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.04229000
7* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.78406015
8* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.71204702
9* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.55035250
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.52235831
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.49407631
12AR_21909140_ChIP-Seq_LNCAP_Human2.47938596
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.45393233
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.32449075
15* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.31173643
16MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.25399242
17* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.24240379
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.22537417
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.20504829
20* E2F1_21310950_ChIP-Seq_MCF-7_Human2.20212186
21* XRN2_22483619_ChIP-Seq_HELA_Human2.18030749
22* MYCN_18555785_ChIP-Seq_MESCs_Mouse2.06550957
23GABP_17652178_ChIP-ChIP_JURKAT_Human2.05081724
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.01320636
25E2F7_22180533_ChIP-Seq_HELA_Human10.3101634
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.96205073
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.95799400
28TP63_19390658_ChIP-ChIP_HaCaT_Human1.91720474
29POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.91709482
30EGR1_19374776_ChIP-ChIP_THP-1_Human1.81461877
31* VDR_23849224_ChIP-Seq_CD4+_Human1.80755454
32SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.79889932
33MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.79834651
34RBPJ_22232070_ChIP-Seq_NCS_Mouse1.79140404
35* TTF2_22483619_ChIP-Seq_HELA_Human1.76950318
36NANOG_18555785_ChIP-Seq_MESCs_Mouse1.76683314
37YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.72173961
38SOX2_18555785_ChIP-Seq_MESCs_Mouse1.71780265
39KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.71610514
40KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.71610514
41KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.71610514
42HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.66475462
43* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.63851577
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62842742
45FOXP3_21729870_ChIP-Seq_TREG_Human1.62716008
46POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.57214634
47DCP1A_22483619_ChIP-Seq_HELA_Human1.56290570
48ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.52851856
49GABP_19822575_ChIP-Seq_HepG2_Human1.49589649
50THAP11_20581084_ChIP-Seq_MESCs_Mouse1.45674631
51EWS_26573619_Chip-Seq_HEK293_Human1.44270679
52POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.40191971
53* ELK1_19687146_ChIP-ChIP_HELA_Human1.38957724
54KDM5A_27292631_Chip-Seq_BREAST_Human1.36923604
55ZFX_18555785_ChIP-Seq_MESCs_Mouse1.36888983
56* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.36651883
57CIITA_25753668_ChIP-Seq_RAJI_Human1.35500906
58HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.32104459
59FUS_26573619_Chip-Seq_HEK293_Human1.28195582
60CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.26036520
61PADI4_21655091_ChIP-ChIP_MCF-7_Human1.25544079
62* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.24544507
63YY1_21170310_ChIP-Seq_MESCs_Mouse1.24334321
64ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.23112985
65NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.22179429
66* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.20445213
67TCF3_18692474_ChIP-Seq_MEFs_Mouse1.18371786
68SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.17606146
69FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.15818641
70KLF4_18555785_ChIP-Seq_MESCs_Mouse1.14230969
71STAT3_1855785_ChIP-Seq_MESCs_Mouse1.13910834
72ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.12343271
73ELF1_17652178_ChIP-ChIP_JURKAT_Human1.11725580
74TCF3_18692474_ChIP-Seq_MESCs_Mouse1.10832049
75* NANOG_21062744_ChIP-ChIP_HESCs_Human1.09468700
76* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09312724
77NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.06426053
78SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.04635099
79ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04376713
80HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.03955304
81* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.02633891
82ZNF274_21170338_ChIP-Seq_K562_Hela1.02189010
83IRF1_19129219_ChIP-ChIP_H3396_Human1.01678333
84MYC_22102868_ChIP-Seq_BL_Human1.01565426
85NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.98834813
86* MYC_18940864_ChIP-ChIP_HL60_Human0.97386439
87PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.95879244
88DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.95864259
89NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.95723113
90PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.95448589
91HOXB4_20404135_ChIP-ChIP_EML_Mouse0.95357693
92ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.94037354
93NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.93521480
94SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.90080338
95TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.90072241
96SOX2_16153702_ChIP-ChIP_HESCs_Human0.89616483
97KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.89264145
98SRF_21415370_ChIP-Seq_HL-1_Mouse0.88820502
99GATA1_26923725_Chip-Seq_HPCs_Mouse0.88404232
100NANOG_16153702_ChIP-ChIP_HESCs_Human0.86498628
101DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.86418632
102ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.86053099
103SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.85563800
104TFEB_21752829_ChIP-Seq_HELA_Human0.84430359
105* SOX17_20123909_ChIP-Seq_XEN_Mouse0.83725350
106CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.83240344
107POU5F1_16153702_ChIP-ChIP_HESCs_Human0.82486739
108SOX2_18692474_ChIP-Seq_MESCs_Mouse0.82204557
109POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.81286238
110SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.80434152
111ESR1_15608294_ChIP-ChIP_MCF-7_Human0.78259217
112SOX2_18692474_ChIP-Seq_MEFs_Mouse0.78159611
113POU5F1_16518401_ChIP-PET_MESCs_Mouse0.77481827
114CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.73900982
115SOX9_26525672_Chip-Seq_HEART_Mouse0.73039886
116NOTCH1_21737748_ChIP-Seq_TLL_Human0.72516946
117GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.69760854
118VDR_22108803_ChIP-Seq_LS180_Human0.68941203

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.50938143
2MP0003693_abnormal_embryo_hatching4.43867178
3MP0008057_abnormal_DNA_replication4.16728604
4MP0003111_abnormal_nucleus_morphology4.14604034
5MP0004957_abnormal_blastocyst_morpholog3.79470477
6MP0003077_abnormal_cell_cycle3.61827200
7MP0008058_abnormal_DNA_repair3.28676653
8MP0008877_abnormal_DNA_methylation3.22998108
9MP0003123_paternal_imprinting2.93004302
10MP0008932_abnormal_embryonic_tissue2.56493796
11MP0008007_abnormal_cellular_replicative2.50836659
12* MP0001730_embryonic_growth_arrest2.28038443
13MP0000350_abnormal_cell_proliferation2.12806161
14MP0010030_abnormal_orbit_morphology2.06973805
15MP0003121_genomic_imprinting2.04804842
16MP0003890_abnormal_embryonic-extraembry1.99524692
17MP0002653_abnormal_ependyma_morphology1.94115306
18MP0001672_abnormal_embryogenesis/_devel1.93279058
19MP0005380_embryogenesis_phenotype1.93279058
20MP0002210_abnormal_sex_determination1.89224759
21MP0002084_abnormal_developmental_patter1.87699840
22MP0002085_abnormal_embryonic_tissue1.87480908
23MP0000537_abnormal_urethra_morphology1.86440726
24MP0001293_anophthalmia1.85541809
25MP0009053_abnormal_anal_canal1.83705046
26MP0005410_abnormal_fertilization1.79639928
27MP0010307_abnormal_tumor_latency1.77155221
28MP0001929_abnormal_gametogenesis1.76508504
29* MP0001697_abnormal_embryo_size1.75523654
30MP0010352_gastrointestinal_tract_polyps1.73054761
31MP0004197_abnormal_fetal_growth/weight/1.69886401
32MP0003786_premature_aging1.69278656
33MP0003984_embryonic_growth_retardation1.67487823
34MP0002088_abnormal_embryonic_growth/wei1.64328665
35MP0006292_abnormal_olfactory_placode1.62110689
36MP0001145_abnormal_male_reproductive1.61673053
37MP0003937_abnormal_limbs/digits/tail_de1.60928183
38MP0003941_abnormal_skin_development1.54898365
39MP0003119_abnormal_digestive_system1.51060165
40* MP0002080_prenatal_lethality1.49073713
41MP0005076_abnormal_cell_differentiation1.48403713
42MP0009697_abnormal_copulation1.47590646
43MP0003315_abnormal_perineum_morphology1.46262534
44MP0003567_abnormal_fetal_cardiomyocyte1.45336618
45MP0003698_abnormal_male_reproductive1.44771755
46MP0002086_abnormal_extraembryonic_tissu1.43801736
47MP0000653_abnormal_sex_gland1.39300681
48MP0004133_heterotaxia1.33224601
49MP0003718_maternal_effect1.32432263
50MP0001529_abnormal_vocalization1.28100019
51MP0002254_reproductive_system_inflammat1.25657718
52MP0000566_synostosis1.24082888
53MP0001188_hyperpigmentation1.20344585
54MP0009672_abnormal_birth_weight1.20261650
55MP0002160_abnormal_reproductive_system1.18606498
56MP0000313_abnormal_cell_death1.16833044
57MP0006072_abnormal_retinal_apoptosis1.15240388
58MP0005394_taste/olfaction_phenotype1.09175560
59MP0005499_abnormal_olfactory_system1.09175560
60MP0009703_decreased_birth_body1.07750670
61MP0001286_abnormal_eye_development1.07640224
62MP0002938_white_spotting1.06439065
63MP0000428_abnormal_craniofacial_morphol1.04690303
64MP0002092_abnormal_eye_morphology1.04387074
65MP0002111_abnormal_tail_morphology1.04355114
66MP0002396_abnormal_hematopoietic_system1.03146839
67MP0003861_abnormal_nervous_system1.02778039
68MP0000432_abnormal_head_morphology1.01696835
69MP0000049_abnormal_middle_ear1.00260459
70MP0002697_abnormal_eye_size0.99025490
71MP0002751_abnormal_autonomic_nervous0.97275751
72MP0003755_abnormal_palate_morphology0.97034363
73MP0002161_abnormal_fertility/fecundity0.96613203
74MP0001299_abnormal_eye_distance/0.95321083
75MP0000631_abnormal_neuroendocrine_gland0.94677032
76MP0003935_abnormal_craniofacial_develop0.93422825
77MP0000579_abnormal_nail_morphology0.92279683
78MP0003115_abnormal_respiratory_system0.91759665
79MP0003938_abnormal_ear_development0.91514454
80MP0002102_abnormal_ear_morphology0.90890158
81MP0002249_abnormal_larynx_morphology0.90473914
82MP0003385_abnormal_body_wall0.89921322
83MP0002282_abnormal_trachea_morphology0.89723959
84MP0000778_abnormal_nervous_system0.88511688
85MP0002019_abnormal_tumor_incidence0.88320635
86MP0002736_abnormal_nociception_after0.88150491
87MP0003283_abnormal_digestive_organ0.88061851
88MP0001177_atelectasis0.86256565
89MP0001346_abnormal_lacrimal_gland0.84343937
90MP0000490_abnormal_crypts_of0.84146485
91MP0006035_abnormal_mitochondrial_morpho0.83010520
92MP0003136_yellow_coat_color0.82802040
93MP0001119_abnormal_female_reproductive0.82643697
94MP0005389_reproductive_system_phenotype0.81629688
95MP0002233_abnormal_nose_morphology0.80416177
96MP0001485_abnormal_pinna_reflex0.77492959
97MP0008789_abnormal_olfactory_epithelium0.77387293
98MP0009379_abnormal_foot_pigmentation0.77337992
99MP0003942_abnormal_urinary_system0.77078905
100MP0002081_perinatal_lethality0.76859204
101MP0002114_abnormal_axial_skeleton0.76244184
102MP0002932_abnormal_joint_morphology0.75956811
103MP0003787_abnormal_imprinting0.75527188
104MP0003122_maternal_imprinting0.74872531
105MP0004808_abnormal_hematopoietic_stem0.74630175
106MP0005623_abnormal_meninges_morphology0.74293563
107MP0002116_abnormal_craniofacial_bone0.73734602
108MP0001849_ear_inflammation0.72945308
109MP0000647_abnormal_sebaceous_gland0.69311323
110MP0005367_renal/urinary_system_phenotyp0.67387401
111MP0000516_abnormal_urinary_system0.67387401
112MP0002152_abnormal_brain_morphology0.67375141
113MP0003936_abnormal_reproductive_system0.66407916
114MP0002234_abnormal_pharynx_morphology0.65288796
115MP0002925_abnormal_cardiovascular_devel0.64106485
116MP0003705_abnormal_hypodermis_morpholog0.63763502
117MP0005187_abnormal_penis_morphology0.63271766
118MP0001915_intracranial_hemorrhage0.63256119
119MP0008995_early_reproductive_senescence0.63102963
120MP0005391_vision/eye_phenotype0.62982834
121MP0000733_abnormal_muscle_development0.60943590
122MP0003699_abnormal_female_reproductive0.60321824
123MP0008770_decreased_survivor_rate0.60154869
124MP0004233_abnormal_muscle_weight0.59635007
125MP0009250_abnormal_appendicular_skeleto0.59348410

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)3.97205759
2Chromosomal breakage induced by crosslinking agents (HP:0003221)3.88654231
3Birth length less than 3rd percentile (HP:0003561)3.79630317
4Medulloblastoma (HP:0002885)3.57321522
5Ependymoma (HP:0002888)3.48448122
6Supernumerary spleens (HP:0009799)3.42696122
7Impulsivity (HP:0100710)3.41413782
8Selective tooth agenesis (HP:0001592)3.35533630
9Breast hypoplasia (HP:0003187)3.27165391
10Colon cancer (HP:0003003)3.26022758
11Abnormality of the labia minora (HP:0012880)3.20940882
12Meckel diverticulum (HP:0002245)3.17370621
13Abnormality of chromosome stability (HP:0003220)3.12040268
14Patellar aplasia (HP:0006443)3.11219240
15Ectopic kidney (HP:0000086)3.05565526
16Absent radius (HP:0003974)3.04339338
17Abnormality of the ileum (HP:0001549)3.01233345
18Aplasia/Hypoplasia of the patella (HP:0006498)2.96564227
19Aplasia/Hypoplasia of the uvula (HP:0010293)2.94359649
20Cortical dysplasia (HP:0002539)2.92734721
21Absent forearm bone (HP:0003953)2.87051547
22Aplasia involving forearm bones (HP:0009822)2.87051547
23Septo-optic dysplasia (HP:0100842)2.83705832
24Abnormality of the preputium (HP:0100587)2.83348035
25Reticulocytopenia (HP:0001896)2.81253580
26Abnormal number of incisors (HP:0011064)2.77382347
27Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.75354117
28Rhabdomyosarcoma (HP:0002859)2.74097266
29Abnormal lung lobation (HP:0002101)2.64574990
30Duodenal stenosis (HP:0100867)2.64065192
31Small intestinal stenosis (HP:0012848)2.64065192
32Degeneration of anterior horn cells (HP:0002398)2.60901039
33Abnormality of the anterior horn cell (HP:0006802)2.60901039
34Increased nuchal translucency (HP:0010880)2.58386292
35Nephroblastoma (Wilms tumor) (HP:0002667)2.56111799
36Volvulus (HP:0002580)2.55453355
37Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.53514055
38Short 4th metacarpal (HP:0010044)2.53514055
39Agnosia (HP:0010524)2.47575133
40Abnormality of the astrocytes (HP:0100707)2.46022433
41Astrocytoma (HP:0009592)2.46022433
42Hepatoblastoma (HP:0002884)2.45912862
43Abnormality of abdominal situs (HP:0011620)2.42602642
44Abdominal situs inversus (HP:0003363)2.42602642
45Atresia of the external auditory canal (HP:0000413)2.41752886
46Embryonal renal neoplasm (HP:0011794)2.41408740
47Aplasia/Hypoplasia of the sternum (HP:0006714)2.41219182
48Absent thumb (HP:0009777)2.40690343
49Proximal placement of thumb (HP:0009623)2.39454897
50Neoplasm of the oral cavity (HP:0100649)2.36552414
51Facial hemangioma (HP:0000329)2.34253890
52Sloping forehead (HP:0000340)2.33528311
53Glioma (HP:0009733)2.32530891
54Carpal bone hypoplasia (HP:0001498)2.31040445
55Abnormality of the duodenum (HP:0002246)2.30526565
56Spastic diplegia (HP:0001264)2.30038024
57Facial cleft (HP:0002006)2.28256878
58Neoplasm of striated muscle (HP:0009728)2.27592924
59Deviation of the thumb (HP:0009603)2.26978358
60Hyperglycinemia (HP:0002154)2.25774388
61Oral leukoplakia (HP:0002745)2.24819589
62Multiple enchondromatosis (HP:0005701)2.19726353
63Abnormality of the carotid arteries (HP:0005344)2.18041204
64Short thumb (HP:0009778)2.16633339
65Horseshoe kidney (HP:0000085)2.16286230
66Triphalangeal thumb (HP:0001199)2.14588402
67Tracheoesophageal fistula (HP:0002575)2.13921952
68Aplasia/hypoplasia of the humerus (HP:0006507)2.13825139
69Duplicated collecting system (HP:0000081)2.13461065
70Bilateral microphthalmos (HP:0007633)2.12973461
71Abnormality of cochlea (HP:0000375)2.12157905
72Neoplasm of the pancreas (HP:0002894)2.12001633
73Supernumerary bones of the axial skeleton (HP:0009144)2.10441234
74Oligodactyly (HP:0012165)2.10259618
75Absent septum pellucidum (HP:0001331)2.09977577
76Rib fusion (HP:0000902)2.09635104
77Intestinal atresia (HP:0011100)2.09595034
78Abnormality of the septum pellucidum (HP:0007375)2.09057789
79Supernumerary ribs (HP:0005815)2.07930168
80Absent/shortened dynein arms (HP:0200106)2.07623738
81Dynein arm defect of respiratory motile cilia (HP:0012255)2.07623738
82Missing ribs (HP:0000921)2.04517846
83Duplication of thumb phalanx (HP:0009942)2.04424968
84Myelodysplasia (HP:0002863)2.03407569
85Neoplasm of the colon (HP:0100273)2.01931882
86Pendular nystagmus (HP:0012043)1.99637701
87Esophageal atresia (HP:0002032)1.99146532
8811 pairs of ribs (HP:0000878)1.98406638
89High anterior hairline (HP:0009890)1.90213723
90Biliary tract neoplasm (HP:0100574)1.90186835
91Renal duplication (HP:0000075)1.89863099
92Abnormality of the renal collecting system (HP:0004742)1.88859670
93Embryonal neoplasm (HP:0002898)1.88786461
94Short humerus (HP:0005792)1.88625811
95Hyperglycinuria (HP:0003108)1.87295639
96Hypoplasia of the capital femoral epiphysis (HP:0003090)1.85769699
97Abnormality of the 4th metacarpal (HP:0010012)1.83893213
98Cleft eyelid (HP:0000625)1.83409491
99Shawl scrotum (HP:0000049)1.83268791
100Choanal atresia (HP:0000453)1.81267761
101Prominent nose (HP:0000448)1.80626355
102Neoplasm of the adrenal cortex (HP:0100641)1.79481241
103Hypoplasia of the radius (HP:0002984)1.79386060
104Morphological abnormality of the inner ear (HP:0011390)1.77664696
105Abnormality of serine family amino acid metabolism (HP:0010894)1.77605467
106Abnormality of glycine metabolism (HP:0010895)1.77605467
107Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.76762370
108Clubbing of toes (HP:0100760)1.76515924
109Cafe-au-lait spot (HP:0000957)1.76368682
110Stenosis of the external auditory canal (HP:0000402)1.75552474
111Abnormal respiratory motile cilium morphology (HP:0005938)1.75515509
112Abnormal respiratory epithelium morphology (HP:0012253)1.75515509
113Bone marrow hypocellularity (HP:0005528)1.75229880
114Aplasia/Hypoplasia of the earlobes (HP:0009906)1.74476960
115Pancreatic islet-cell hyperplasia (HP:0004510)1.74306311
116Rough bone trabeculation (HP:0100670)1.73613028
117Anophthalmia (HP:0000528)1.73056628
118Gastrointestinal atresia (HP:0002589)1.72599248
119Breast aplasia (HP:0100783)1.72592956
120Skull defect (HP:0001362)1.72342724
121Abnormal spermatogenesis (HP:0008669)1.70460341
122Rectovaginal fistula (HP:0000143)1.70443432
123Rectal fistula (HP:0100590)1.70443432
124Bifid tongue (HP:0010297)1.70065668
125Basal cell carcinoma (HP:0002671)1.70003599
126Hemivertebrae (HP:0002937)1.69686699
127Aplasia/Hypoplasia of the breasts (HP:0010311)1.68189260
128Aqueductal stenosis (HP:0002410)1.67963637
129Microglossia (HP:0000171)1.65772604
130Anal stenosis (HP:0002025)1.65136667
131Microtia (HP:0008551)1.64339896
132Abnormality of serum amino acid levels (HP:0003112)1.63960095
133Preaxial hand polydactyly (HP:0001177)1.63905851
134Shoulder girdle muscle weakness (HP:0003547)1.61397161
135Hypoplasia of the pons (HP:0012110)1.61075197
136Abnormality of cells of the erythroid lineage (HP:0012130)1.60334785
137Gonadotropin excess (HP:0000837)1.59000835
138Dandy-Walker malformation (HP:0001305)1.58736970
139Choanal stenosis (HP:0000452)1.58227220
140Renal hypoplasia (HP:0000089)1.57082280
141Abnormal hair whorl (HP:0010721)1.56152354
142Holoprosencephaly (HP:0001360)1.55124254
143Oligodactyly (hands) (HP:0001180)1.54326035

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.16592055
2WEE14.22400341
3BUB13.64816396
4NEK23.14050255
5TTK2.96065355
6SRPK12.92349625
7CDK122.91008184
8VRK22.67915997
9MKNK12.51314283
10PNCK2.48845831
11TNIK2.46398654
12PLK42.35534569
13EIF2AK12.26157586
14TSSK62.17820117
15PLK12.13859526
16TAF12.10805784
17MKNK22.08036337
18PLK31.97841142
19NEK11.94642206
20ATR1.93418455
21PASK1.89294308
22BRSK21.86311585
23PDK41.86030864
24PDK31.86030864
25CHEK21.82379236
26ACVR1B1.80330887
27CDK71.77219752
28BRD41.70503314
29DYRK31.67506473
30AURKB1.65588118
31CHEK11.63095408
32NUAK11.53681736
33CDK41.35630715
34TLK11.35081836
35RPS6KB21.33699640
36VRK11.27817914
37STK38L1.25540655
38LATS11.22735762
39* ATM1.20731344
40EIF2AK31.20075818
41PDK21.16947502
42EPHA21.16284250
43AURKA1.16218937
44CDK21.08125579
45TESK21.07803873
46MAP3K81.07792683
47LATS21.07503063
48STK31.06646141
49BRSK11.06573090
50BMPR1B1.00155433
51RPS6KA40.99999071
52TRIM280.99474961
53CCNB10.96161160
54NME10.93050165
55TGFBR10.92993910
56FGFR20.92787832
57CDK60.92559437
58STK160.92175858
59STK40.92000632
60SMG10.90915354
61* CDK10.88013708
62MAP3K100.87976114
63ALK0.86972091
64ZAK0.86503028
65TESK10.85500749
66CAMK1G0.82990588
67MELK0.81268283
68PAK40.80679508
69MAP3K40.77215543
70CDK190.75011911
71STK100.74487176
72ICK0.73873654
73CSNK2A20.73155588
74CDK30.71999880
75MTOR0.70593282
76PLK20.69263938
77CAMK1D0.68192856
78MST40.67423046
79CASK0.66807795
80CSNK1E0.66153980
81PBK0.65282101
82EEF2K0.64939124
83CSNK2A10.64582488
84AKT30.62406158
85CSNK1D0.58279487
86ERBB40.57767901
87PAK10.56308414
88PRKCI0.53679098
89EIF2AK20.51267728
90FGFR10.50893977
91DYRK20.50479767
92* PRKDC0.48700322
93PIM10.47073610
94CDK80.45642953
95ERBB30.44200088
96NME20.43943759
97BCR0.42122492
98BRAF0.41594227
99MAPK140.41582515
100CDK11A0.41433792
101CDK180.39691239
102CDK150.39376863
103CLK10.37943330
104RPS6KA50.37098884
105YES10.37092255
106GSK3B0.36591104
107AKT20.35488502
108DMPK0.35405664
109UHMK10.35003398
110STK240.34219256
111SCYL20.33704707
112PAK20.31631606
113NLK0.31102965
114CSNK1G20.30893944
115AKT10.30208546
116CDK140.29992223
117MAP3K90.28683221
118DYRK1A0.28414084
119OXSR10.27126121
120MAPK10.25775405
121CDK90.25570641
122MET0.24232279
123CSNK1G30.23899826
124WNK30.22552223
125CSNK1G10.22441133
126EPHB20.22177172
127CSNK1A1L0.22025607
128MAPK100.21928744
129PRKD30.21922777
130TYRO30.19575173

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.82383459
2Mismatch repair_Homo sapiens_hsa034304.44693445
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.89692766
4Spliceosome_Homo sapiens_hsa030403.74747335
5RNA transport_Homo sapiens_hsa030133.66337492
6Homologous recombination_Homo sapiens_hsa034403.24797435
7Cell cycle_Homo sapiens_hsa041103.19122925
8RNA polymerase_Homo sapiens_hsa030202.97389274
9Fanconi anemia pathway_Homo sapiens_hsa034602.96345232
10Nucleotide excision repair_Homo sapiens_hsa034202.89148034
11Base excision repair_Homo sapiens_hsa034102.87210299
12One carbon pool by folate_Homo sapiens_hsa006702.59470445
13Basal transcription factors_Homo sapiens_hsa030222.51769757
14mRNA surveillance pathway_Homo sapiens_hsa030152.49067574
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.40647581
16Proteasome_Homo sapiens_hsa030502.38142543
17Ribosome_Homo sapiens_hsa030102.35544531
18Non-homologous end-joining_Homo sapiens_hsa034502.31764231
19Pyrimidine metabolism_Homo sapiens_hsa002402.20507419
20RNA degradation_Homo sapiens_hsa030182.17612105
21p53 signaling pathway_Homo sapiens_hsa041151.60738957
22Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.52009415
23Protein export_Homo sapiens_hsa030601.51897376
24Oocyte meiosis_Homo sapiens_hsa041141.46236661
25Basal cell carcinoma_Homo sapiens_hsa052171.35612566
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.32374017
27Systemic lupus erythematosus_Homo sapiens_hsa053221.30912157
28Purine metabolism_Homo sapiens_hsa002301.26751308
29Propanoate metabolism_Homo sapiens_hsa006401.24109212
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.20315756
31Pyruvate metabolism_Homo sapiens_hsa006201.20262668
32Steroid biosynthesis_Homo sapiens_hsa001001.18376541
33Epstein-Barr virus infection_Homo sapiens_hsa051691.18011357
34Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.17404743
35Hippo signaling pathway_Homo sapiens_hsa043901.02028796
36Hedgehog signaling pathway_Homo sapiens_hsa043401.01795620
37Viral carcinogenesis_Homo sapiens_hsa052031.00580460
38Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.99034626
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.98914688
40Vitamin B6 metabolism_Homo sapiens_hsa007500.95903764
41Selenocompound metabolism_Homo sapiens_hsa004500.94060726
42MicroRNAs in cancer_Homo sapiens_hsa052060.93907453
43Herpes simplex infection_Homo sapiens_hsa051680.86270793
44Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.85953185
45HTLV-I infection_Homo sapiens_hsa051660.85778139
46TGF-beta signaling pathway_Homo sapiens_hsa043500.85149973
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.84654218
48Parkinsons disease_Homo sapiens_hsa050120.83018200
49Cysteine and methionine metabolism_Homo sapiens_hsa002700.80689578
50Antigen processing and presentation_Homo sapiens_hsa046120.79937433
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.79716785
52Biosynthesis of amino acids_Homo sapiens_hsa012300.67229123
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.67031345
54Oxidative phosphorylation_Homo sapiens_hsa001900.66261505
55Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.62415271
56Wnt signaling pathway_Homo sapiens_hsa043100.62395390
57Thyroid cancer_Homo sapiens_hsa052160.61716655
58Fatty acid elongation_Homo sapiens_hsa000620.61370160
59Notch signaling pathway_Homo sapiens_hsa043300.60005034
60Adherens junction_Homo sapiens_hsa045200.59281482
61Pentose phosphate pathway_Homo sapiens_hsa000300.58666710
62Small cell lung cancer_Homo sapiens_hsa052220.57561915
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57351612
64Alcoholism_Homo sapiens_hsa050340.53987806
65Colorectal cancer_Homo sapiens_hsa052100.52959127
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47384227
67Huntingtons disease_Homo sapiens_hsa050160.46314058
68Cyanoamino acid metabolism_Homo sapiens_hsa004600.46274855
69Tight junction_Homo sapiens_hsa045300.45473609
70Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.45000410
71Lysine degradation_Homo sapiens_hsa003100.43869013
72Butanoate metabolism_Homo sapiens_hsa006500.43062123
73Pathways in cancer_Homo sapiens_hsa052000.42763427
74Prostate cancer_Homo sapiens_hsa052150.39755339
75Drug metabolism - other enzymes_Homo sapiens_hsa009830.39256203
76Fatty acid metabolism_Homo sapiens_hsa012120.38998758
77Glutathione metabolism_Homo sapiens_hsa004800.37636097
78Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.37603209
79Arginine and proline metabolism_Homo sapiens_hsa003300.36844175
80Sulfur relay system_Homo sapiens_hsa041220.32832631
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.32146347
82Vitamin digestion and absorption_Homo sapiens_hsa049770.32011608
83Central carbon metabolism in cancer_Homo sapiens_hsa052300.28347356
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.27883704
85Nicotine addiction_Homo sapiens_hsa050330.27368845
86Alzheimers disease_Homo sapiens_hsa050100.26588710
87Legionellosis_Homo sapiens_hsa051340.26567334
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.26362544
89Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.25099259
90beta-Alanine metabolism_Homo sapiens_hsa004100.23574012
91Carbon metabolism_Homo sapiens_hsa012000.23336744
92Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.23318879
93Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.23007048
94Viral myocarditis_Homo sapiens_hsa054160.22513997
95mTOR signaling pathway_Homo sapiens_hsa041500.21955645
96Bladder cancer_Homo sapiens_hsa052190.21453859
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.20448240
98HIF-1 signaling pathway_Homo sapiens_hsa040660.18904026
99Linoleic acid metabolism_Homo sapiens_hsa005910.18397923
100Phototransduction_Homo sapiens_hsa047440.18349817
101Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.17577894
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.17494985
103Melanoma_Homo sapiens_hsa052180.17391235
104Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.16501657
105Folate biosynthesis_Homo sapiens_hsa007900.16346830
106Fatty acid degradation_Homo sapiens_hsa000710.15943615
107Chronic myeloid leukemia_Homo sapiens_hsa052200.15017902
108Taste transduction_Homo sapiens_hsa047420.14930590
109Apoptosis_Homo sapiens_hsa042100.14280227
110Hepatitis B_Homo sapiens_hsa051610.13483259
111Proteoglycans in cancer_Homo sapiens_hsa052050.13451250
112Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.13318892
113Cardiac muscle contraction_Homo sapiens_hsa042600.11830747
114FoxO signaling pathway_Homo sapiens_hsa040680.11023745
115PI3K-Akt signaling pathway_Homo sapiens_hsa041510.09828476
116NOD-like receptor signaling pathway_Homo sapiens_hsa046210.09477550
117Endometrial cancer_Homo sapiens_hsa052130.09291817
118Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.08173525
119Tryptophan metabolism_Homo sapiens_hsa003800.07973571
120Glucagon signaling pathway_Homo sapiens_hsa049220.07918184
121Influenza A_Homo sapiens_hsa051640.06559697
122alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.06475249
123Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.06295942
124Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.06135325
125Nitrogen metabolism_Homo sapiens_hsa009100.06067941
126Renin-angiotensin system_Homo sapiens_hsa046140.05842726
127Peroxisome_Homo sapiens_hsa041460.05463080
128Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.04775622
129Dorso-ventral axis formation_Homo sapiens_hsa043200.04433930
130Metabolic pathways_Homo sapiens_hsa011000.04011689
131Arachidonic acid metabolism_Homo sapiens_hsa005900.01965043
132Fructose and mannose metabolism_Homo sapiens_hsa000510.01560737
133N-Glycan biosynthesis_Homo sapiens_hsa005100.01124426
134NF-kappa B signaling pathway_Homo sapiens_hsa040640.00763605
135Melanogenesis_Homo sapiens_hsa049160.00011440

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