NAT10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an RNA cytidine acetyltransferase involved in histone acetylation, tRNA acetylation, the biosynthesis of 18S rRNA, and the enhancement of nuclear architecture and chromatin organization. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)7.54810843
2transcription from mitochondrial promoter (GO:0006390)6.37286508
3replication fork processing (GO:0031297)6.05675971
4embryonic process involved in female pregnancy (GO:0060136)5.98724530
5proline metabolic process (GO:0006560)5.47694686
6maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)5.35254313
7somatic hypermutation of immunoglobulin genes (GO:0016446)5.22987601
8somatic diversification of immune receptors via somatic mutation (GO:0002566)5.22987601
9DNA deamination (GO:0045006)5.10779113
10regulation of translational fidelity (GO:0006450)4.92743770
11mitotic chromosome condensation (GO:0007076)4.79900804
12formation of translation preinitiation complex (GO:0001731)4.74384880
13DNA strand renaturation (GO:0000733)4.71299328
14mitochondrial DNA metabolic process (GO:0032042)4.70066386
15establishment of apical/basal cell polarity (GO:0035089)4.66884669
16establishment of integrated proviral latency (GO:0075713)4.61403306
17pore complex assembly (GO:0046931)4.61151526
18mitotic G1 DNA damage checkpoint (GO:0031571)4.53857780
19regulation of integrin activation (GO:0033623)4.46855792
20positive regulation of protein homooligomerization (GO:0032464)4.45638977
21telomere maintenance via semi-conservative replication (GO:0032201)4.40516316
22negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.32321652
23oxidative demethylation (GO:0070989)4.29648244
24mRNA cleavage (GO:0006379)4.27582455
25protein localization to chromosome, centromeric region (GO:0071459)4.26413086
26viral mRNA export from host cell nucleus (GO:0046784)4.23314003
27spliceosomal tri-snRNP complex assembly (GO:0000244)4.21473236
28DNA strand elongation involved in DNA replication (GO:0006271)4.13607848
29dosage compensation (GO:0007549)4.08630089
30maturation of SSU-rRNA (GO:0030490)4.03760045
31regulation of RNA export from nucleus (GO:0046831)4.03251251
32ribosome assembly (GO:0042255)4.03049521
33base-excision repair (GO:0006284)4.00617520
34mitotic G1/S transition checkpoint (GO:0044819)3.99710484
35G1 DNA damage checkpoint (GO:0044783)3.96623643
36establishment or maintenance of monopolar cell polarity (GO:0061339)3.92382578
37establishment of monopolar cell polarity (GO:0061162)3.92382578
38mitotic sister chromatid cohesion (GO:0007064)3.92252938
39poly(A)+ mRNA export from nucleus (GO:0016973)3.90221857
40positive regulation of mitotic sister chromatid separation (GO:1901970)3.89755659
41positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.89755659
42positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.89755659
43DNA strand elongation (GO:0022616)3.89443288
44negative regulation of mRNA processing (GO:0050686)3.83962860
45regulation of protein homooligomerization (GO:0032462)3.83873121
46meiotic chromosome segregation (GO:0045132)3.82958904
47regulation of gene silencing by RNA (GO:0060966)3.81069540
48regulation of posttranscriptional gene silencing (GO:0060147)3.81069540
49regulation of gene silencing by miRNA (GO:0060964)3.81069540
50nucleotide-excision repair, DNA gap filling (GO:0006297)3.80652343
51ribonucleoprotein complex biogenesis (GO:0022613)3.75562154
52mitotic metaphase plate congression (GO:0007080)3.71472105
53histone H4-K12 acetylation (GO:0043983)3.70791134
54telomere maintenance via recombination (GO:0000722)3.70563200
55IMP metabolic process (GO:0046040)3.69799559
56regulation of sister chromatid cohesion (GO:0007063)3.68728076
57establishment of viral latency (GO:0019043)3.68544171
58ribosomal small subunit biogenesis (GO:0042274)3.67815273
59DNA replication checkpoint (GO:0000076)3.67592363
60mitochondrial RNA metabolic process (GO:0000959)3.63139626
61embryonic placenta development (GO:0001892)3.62639285
62positive regulation of chromosome segregation (GO:0051984)3.62019863
63mitotic sister chromatid segregation (GO:0000070)3.58304682
64peptidyl-arginine omega-N-methylation (GO:0035247)3.57663697
65termination of RNA polymerase II transcription (GO:0006369)3.56810832
66pre-miRNA processing (GO:0031054)3.56748017
67mitotic nuclear envelope disassembly (GO:0007077)3.56747903
68DNA double-strand break processing (GO:0000729)3.54961016
69negative regulation of RNA splicing (GO:0033119)3.53861133
70non-recombinational repair (GO:0000726)3.53793725
71double-strand break repair via nonhomologous end joining (GO:0006303)3.53793725
72nucleobase biosynthetic process (GO:0046112)3.53213003
73DNA topological change (GO:0006265)3.52285411
74tRNA aminoacylation for protein translation (GO:0006418)3.47879336
75maturation of 5.8S rRNA (GO:0000460)3.45163005
76DNA conformation change (GO:0071103)3.43304902
77trophectodermal cell differentiation (GO:0001829)3.42015891
78regulation of DNA damage checkpoint (GO:2000001)3.40404205
79amino acid activation (GO:0043038)3.40021362
80tRNA aminoacylation (GO:0043039)3.40021362
81regulation of translational termination (GO:0006449)3.39540167
82DNA unwinding involved in DNA replication (GO:0006268)3.38734554
83regulation of double-strand break repair via homologous recombination (GO:0010569)3.38118237
84negative regulation of cell cycle arrest (GO:0071157)3.37076662
85establishment of protein localization to mitochondrial membrane (GO:0090151)3.36969142
86mitotic recombination (GO:0006312)3.35803412
87ribosomal large subunit biogenesis (GO:0042273)3.34307752
88kinetochore assembly (GO:0051382)3.30431351
89nuclear envelope disassembly (GO:0051081)3.30090987
90membrane disassembly (GO:0030397)3.30090987
91purine nucleobase biosynthetic process (GO:0009113)3.29600225
92negative regulation of mRNA metabolic process (GO:1903312)3.28696888
93telomere maintenance via telomere lengthening (GO:0010833)3.27672201
94DNA duplex unwinding (GO:0032508)3.27419409
95nuclear envelope organization (GO:0006998)3.27316280
96regulation of double-strand break repair (GO:2000779)3.26810980
97determination of adult lifespan (GO:0008340)3.25650398
98chromosome condensation (GO:0030261)3.25564796
99DNA geometric change (GO:0032392)3.25077114
100protein export from nucleus (GO:0006611)3.24805131
101nuclear pore organization (GO:0006999)3.22496650
102regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.21556426
103protein complex localization (GO:0031503)3.20734138
104positive regulation by host of viral transcription (GO:0043923)3.20469638
105ribosome biogenesis (GO:0042254)3.19191566
106folic acid-containing compound biosynthetic process (GO:0009396)3.16568986
107sister chromatid segregation (GO:0000819)3.16064710
108DNA integration (GO:0015074)3.15129357
109protein localization to kinetochore (GO:0034501)3.13835177
110nodal signaling pathway (GO:0038092)3.12993797
111kinetochore organization (GO:0051383)3.12624175
112mRNA export from nucleus (GO:0006406)3.12506886
113rRNA processing (GO:0006364)3.12182640
114negative regulation of JAK-STAT cascade (GO:0046426)3.12145257
115mRNA transport (GO:0051028)3.11167628
116metaphase plate congression (GO:0051310)3.11080587
117histone arginine methylation (GO:0034969)3.09675386
118DNA replication initiation (GO:0006270)3.09647880
119RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.06333050
120mRNA splicing, via spliceosome (GO:0000398)3.06333050
121regulation of nucleobase-containing compound transport (GO:0032239)3.03849009
122regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.03791355
123peptidyl-arginine N-methylation (GO:0035246)3.03482378
124peptidyl-arginine methylation (GO:0018216)3.03482378
125RNA splicing, via transesterification reactions (GO:0000375)3.01211897
126heterochromatin organization (GO:0070828)3.01028154
127nuclear pore complex assembly (GO:0051292)3.00513369
128RNA export from nucleus (GO:0006405)3.00079653
129negative regulation of fatty acid biosynthetic process (GO:0045717)3.00001481
130rRNA metabolic process (GO:0016072)2.97592394
131regulation of mitotic spindle organization (GO:0060236)2.96954566
132ribosomal small subunit assembly (GO:0000028)2.94991068
133nucleosome disassembly (GO:0006337)2.94903242
134protein-DNA complex disassembly (GO:0032986)2.94903242
135apoptotic process involved in morphogenesis (GO:0060561)2.94470628
136regulation of translational elongation (GO:0006448)2.93376217
137DNA ligation (GO:0006266)2.92793554
138base-excision repair, AP site formation (GO:0006285)2.91413555
139resolution of meiotic recombination intermediates (GO:0000712)2.91020174
140spliceosomal snRNP assembly (GO:0000387)2.90611971
141DNA packaging (GO:0006323)2.89591098
142chromatin assembly or disassembly (GO:0006333)2.88863353
143positive regulation of protein oligomerization (GO:0032461)2.88764898
144negative regulation of histone methylation (GO:0031061)2.88357326
145glutamine family amino acid biosynthetic process (GO:0009084)2.87760697
146IMP biosynthetic process (GO:0006188)2.86545661
147chromosome segregation (GO:0007059)2.86460213
148L-serine metabolic process (GO:0006563)2.84735605
149ATP-dependent chromatin remodeling (GO:0043044)2.84538486
150cellular protein complex localization (GO:0034629)2.83747383
151Golgi transport vesicle coating (GO:0048200)2.83568909
152COPI coating of Golgi vesicle (GO:0048205)2.83568909
153regulation of histone H3-K9 methylation (GO:0051570)2.81519139
154rRNA transcription (GO:0009303)2.81369965
155tRNA methylation (GO:0030488)2.81149003
156establishment of RNA localization (GO:0051236)2.79865534

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.48803122
2* MYC_18555785_ChIP-Seq_MESCs_Mouse3.63991512
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.37013584
4SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.92703364
5* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.90545696
6* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.81372398
7* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.64963938
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.55878618
9KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.48748345
10KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.48748345
11KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.48748345
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.41875630
13ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.39022572
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.38526471
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.38300937
16MYC_22102868_ChIP-Seq_BL_Human2.25644575
17VDR_21846776_ChIP-Seq_THP-1_Human2.07016571
18ELF1_17652178_ChIP-ChIP_JURKAT_Human1.93715699
19POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.93161784
20DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.92975132
21NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.88355346
22SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.86074226
23STAT3_1855785_ChIP-Seq_MESCs_Mouse1.85354998
24SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.78799225
25* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.77422384
26NELFA_20434984_ChIP-Seq_ESCs_Mouse1.75828125
27KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.75460523
28NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.75407509
29MYCN_18555785_ChIP-Seq_MESCs_Mouse1.74883222
30NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.72898298
31CIITA_25753668_ChIP-Seq_RAJI_Human1.69920707
32* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.69673741
33* ETS1_20019798_ChIP-Seq_JURKAT_Human1.68057779
34POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.67152124
35E2F1_21310950_ChIP-Seq_MCF-7_Human1.65995535
36RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65910075
37TCF3_18692474_ChIP-Seq_MESCs_Mouse1.62727197
38POU5F1_16518401_ChIP-PET_MESCs_Mouse1.60362606
39* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.59501175
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.57953907
41* XRN2_22483619_ChIP-Seq_HELA_Human1.57479169
42* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.57418775
43NANOG_21062744_ChIP-ChIP_HESCs_Human1.56110183
44CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.53853089
45TCF3_18692474_ChIP-Seq_MEFs_Mouse1.53744152
46KLF4_18555785_ChIP-Seq_MESCs_Mouse1.53255261
47* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52687232
48EGR1_19374776_ChIP-ChIP_THP-1_Human1.52675327
49* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.50980169
50KDM5A_27292631_Chip-Seq_BREAST_Human1.50273134
51SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.47846685
52GABP_19822575_ChIP-Seq_HepG2_Human1.46265984
53ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.41659271
54NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.40845890
55POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.39947582
56FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.39710902
57ESR1_15608294_ChIP-ChIP_MCF-7_Human1.39049932
58EST1_17652178_ChIP-ChIP_JURKAT_Human1.38492332
59HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.38148821
60HOXB4_20404135_ChIP-ChIP_EML_Mouse1.37939370
61DCP1A_22483619_ChIP-Seq_HELA_Human1.35438048
62* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.35009441
63* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.34425350
64YY1_21170310_ChIP-Seq_MESCs_Mouse1.34262708
65TTF2_22483619_ChIP-Seq_HELA_Human1.33389021
66ZFX_18555785_ChIP-Seq_MESCs_Mouse1.31978086
67E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.31245750
68SALL1_21062744_ChIP-ChIP_HESCs_Human1.31216962
69ERG_20887958_ChIP-Seq_HPC-7_Mouse1.29254781
70ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.28174048
71PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.27173744
72PADI4_21655091_ChIP-ChIP_MCF-7_Human1.26926252
73NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.26766994
74SOX2_18555785_ChIP-Seq_MESCs_Mouse1.25044150
75TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23816921
76* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.22897753
77* VDR_23849224_ChIP-Seq_CD4+_Human1.22225788
78PU.1_20513432_ChIP-Seq_Bcells_Mouse1.22197437
79NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.21359489
80MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.21339372
81ELK1_19687146_ChIP-ChIP_HELA_Human1.20655792
82NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.20646843
83BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.17986679
84TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.17803315
85AR_21909140_ChIP-Seq_LNCAP_Human1.17278465
86* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.16098109
87DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.16005640
88* SRF_21415370_ChIP-Seq_HL-1_Mouse1.15928416
89TFEB_21752829_ChIP-Seq_HELA_Human1.15174882
90SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.14596897
91PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.14562902
92* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.14455792
93* LXR_22292898_ChIP-Seq_THP-1_Human1.09751237
94ZNF263_19887448_ChIP-Seq_K562_Human1.09671432
95SOX2_18692474_ChIP-Seq_MESCs_Mouse1.09558737
96GABP_17652178_ChIP-ChIP_JURKAT_Human1.09116629
97SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.08251706
98FOXP3_21729870_ChIP-Seq_TREG_Human1.07794764
99KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.07011083
100KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.06956604
101MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.05944160
102CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05406729
103CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05164562
104CHD1_26751641_Chip-Seq_LNCaP_Human1.03951836
105HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.03332702
106YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03070980
107OCT4_18692474_ChIP-Seq_MEFs_Mouse1.01680824
108CREB1_15753290_ChIP-ChIP_HEK293T_Human1.01413818
109SOX2_18692474_ChIP-Seq_MEFs_Mouse1.01315559
110GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.00923257
111KDM2B_26808549_Chip-Seq_DND41_Human1.00834295
112SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.00780376
113NANOG_18692474_ChIP-Seq_MESCs_Mouse0.99794653
114ZFP281_27345836_Chip-Seq_ESCs_Mouse0.99129890
115TP63_19390658_ChIP-ChIP_HaCaT_Human0.98717095
116* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.98647880
117ZFP281_18757296_ChIP-ChIP_E14_Mouse0.97032482
118EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96664098
119RACK7_27058665_Chip-Seq_MCF-7_Human0.95856906
120E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.95179629
121SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.94255205
122FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.94120352
123TCF7_22412390_ChIP-Seq_EML_Mouse0.93941347
124* CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.92476262
125* TET1_21451524_ChIP-Seq_MESCs_Mouse0.92258313
126SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.90550833
127ELK3_25401928_ChIP-Seq_HUVEC_Human0.90164651
128NCOR1_26117541_ChIP-Seq_K562_Human0.86355951
129* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.86074233
130* CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.85929149
131TBX5_21415370_ChIP-Seq_HL-1_Mouse0.85180546
132TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.84644025
133NOTCH1_21737748_ChIP-Seq_TLL_Human0.82348647
134SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.77435877
135* SOX17_20123909_ChIP-Seq_XEN_Mouse0.76885208
136ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.74501197

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication6.15832686
2MP0010094_abnormal_chromosome_stability3.80026885
3MP0009278_abnormal_bone_marrow3.43217460
4MP0004957_abnormal_blastocyst_morpholog3.23329798
5MP0003111_abnormal_nucleus_morphology3.21933476
6MP0003693_abnormal_embryo_hatching3.02099662
7MP0010030_abnormal_orbit_morphology2.84115579
8MP0003077_abnormal_cell_cycle2.65776634
9MP0008058_abnormal_DNA_repair2.58318376
10MP0010352_gastrointestinal_tract_polyps2.57489886
11MP0004233_abnormal_muscle_weight2.44119044
12MP0005171_absent_coat_pigmentation2.33546672
13MP0003890_abnormal_embryonic-extraembry2.26955684
14MP0008877_abnormal_DNA_methylation2.24342729
15MP0003786_premature_aging2.19536872
16MP0005076_abnormal_cell_differentiation2.12281675
17MP0001545_abnormal_hematopoietic_system2.11185754
18MP0005397_hematopoietic_system_phenotyp2.11185754
19MP0002009_preneoplasia2.06535647
20MP0008995_early_reproductive_senescence1.97929966
21MP0001730_embryonic_growth_arrest1.97067754
22MP0008932_abnormal_embryonic_tissue1.96776759
23MP0002086_abnormal_extraembryonic_tissu1.93251894
24MP0002084_abnormal_developmental_patter1.89423039
25MP0001697_abnormal_embryo_size1.89413150
26MP0000350_abnormal_cell_proliferation1.87628802
27MP0004197_abnormal_fetal_growth/weight/1.84651900
28MP0001672_abnormal_embryogenesis/_devel1.82495519
29MP0005380_embryogenesis_phenotype1.82495519
30MP0002877_abnormal_melanocyte_morpholog1.80848859
31MP0004133_heterotaxia1.77719124
32MP0002085_abnormal_embryonic_tissue1.75006630
33MP0000490_abnormal_crypts_of1.73219166
34MP0003119_abnormal_digestive_system1.72645716
35MP0010307_abnormal_tumor_latency1.72409957
36MP0001293_anophthalmia1.69081349
37MP0001661_extended_life_span1.66987458
38MP0009672_abnormal_birth_weight1.66418295
39MP0003283_abnormal_digestive_organ1.64116822
40MP0002653_abnormal_ependyma_morphology1.61577528
41MP0002396_abnormal_hematopoietic_system1.61186916
42MP0004185_abnormal_adipocyte_glucose1.56581921
43MP0003984_embryonic_growth_retardation1.55961917
44MP0005174_abnormal_tail_pigmentation1.54046921
45MP0003567_abnormal_fetal_cardiomyocyte1.52790972
46MP0002088_abnormal_embryonic_growth/wei1.50945885
47MP0006035_abnormal_mitochondrial_morpho1.47275561
48MP0002080_prenatal_lethality1.46958977
49MP0010234_abnormal_vibrissa_follicle1.43733894
50MP0005451_abnormal_body_composition1.40269564
51MP0002019_abnormal_tumor_incidence1.35134145
52MP0000371_diluted_coat_color1.29488077
53MP0008007_abnormal_cellular_replicative1.27218235
54MP0009697_abnormal_copulation1.25060337
55MP0006072_abnormal_retinal_apoptosis1.21759850
56MP0003453_abnormal_keratinocyte_physiol1.21588908
57MP0000358_abnormal_cell_content/1.21100685
58MP0005075_abnormal_melanosome_morpholog1.20410081
59MP0004264_abnormal_extraembryonic_tissu1.18664194
60MP0002249_abnormal_larynx_morphology1.18590369
61MP0000313_abnormal_cell_death1.18403842
62MP0003941_abnormal_skin_development1.16565744
63MP0001348_abnormal_lacrimal_gland1.13749313
64MP0003172_abnormal_lysosome_physiology1.09305583
65MP0002269_muscular_atrophy1.08601202
66MP0005384_cellular_phenotype1.06176951
67MP0002111_abnormal_tail_morphology1.05921682
68MP0001873_stomach_inflammation1.05475761
69MP0003705_abnormal_hypodermis_morpholog1.04333027
70MP0005621_abnormal_cell_physiology1.03929399
71MP0003315_abnormal_perineum_morphology0.99498188
72MP0002282_abnormal_trachea_morphology0.99350963
73MP0000537_abnormal_urethra_morphology0.96428863
74MP0001346_abnormal_lacrimal_gland0.96094932
75MP0000470_abnormal_stomach_morphology0.95460315
76MP0003763_abnormal_thymus_physiology0.92053375
77MP0001145_abnormal_male_reproductive0.90644731
78MP0003221_abnormal_cardiomyocyte_apopto0.90488093
79MP0001849_ear_inflammation0.89441128
80MP0009333_abnormal_splenocyte_physiolog0.89223116
81MP0003718_maternal_effect0.87747952
82MP0003566_abnormal_cell_adhesion0.87599090
83MP0002075_abnormal_coat/hair_pigmentati0.87561111
84MP0009053_abnormal_anal_canal0.86301546
85MP0000015_abnormal_ear_pigmentation0.84924958
86MP0000703_abnormal_thymus_morphology0.83856143
87MP0000689_abnormal_spleen_morphology0.81559671
88MP0001727_abnormal_embryo_implantation0.80922774
89MP0002210_abnormal_sex_determination0.80428336
90MP0005023_abnormal_wound_healing0.80219239
91MP0005266_abnormal_metabolism0.79468893
92MP0000579_abnormal_nail_morphology0.78356253
93MP0003935_abnormal_craniofacial_develop0.78219623
94MP0002932_abnormal_joint_morphology0.77996663
95MP0001216_abnormal_epidermal_layer0.77220058
96MP0001915_intracranial_hemorrhage0.76843542
97MP0003806_abnormal_nucleotide_metabolis0.75963934
98MP0000432_abnormal_head_morphology0.74925566
99MP0003123_paternal_imprinting0.74119038
100MP0003656_abnormal_erythrocyte_physiolo0.73998800
101MP0004808_abnormal_hematopoietic_stem0.73985389
102MP0002405_respiratory_system_inflammati0.73858761
103MP0005501_abnormal_skin_physiology0.73196105
104MP0001881_abnormal_mammary_gland0.72971807
105MP0002114_abnormal_axial_skeleton0.72795897
106MP0000477_abnormal_intestine_morphology0.71983773
107MP0000685_abnormal_immune_system0.71286574
108MP0002398_abnormal_bone_marrow0.70892703
109MP0002060_abnormal_skin_morphology0.70398459
110MP0002722_abnormal_immune_system0.69818304
111MP0001929_abnormal_gametogenesis0.68931390
112MP0002006_tumorigenesis0.68909810
113MP0001853_heart_inflammation0.68352843
114MP0000653_abnormal_sex_gland0.67881238
115MP0000377_abnormal_hair_follicle0.67778019
116MP0002796_impaired_skin_barrier0.67776979
117MP0003937_abnormal_limbs/digits/tail_de0.67579812
118MP0000462_abnormal_digestive_system0.67194707
119MP0006292_abnormal_olfactory_placode0.66063025
120MP0000428_abnormal_craniofacial_morphol0.65022081
121MP0009115_abnormal_fat_cell0.64076987
122MP0006036_abnormal_mitochondrial_physio0.64057813
123MP0001186_pigmentation_phenotype0.63621358
124MP0009931_abnormal_skin_appearance0.63340079
125MP0008260_abnormal_autophagy0.63081027
126MP0010630_abnormal_cardiac_muscle0.63038631
127MP0000627_abnormal_mammary_gland0.61584650
128MP0002166_altered_tumor_susceptibility0.61540235
129MP0002697_abnormal_eye_size0.61347587
130MP0001340_abnormal_eyelid_morphology0.61120194
131MP0003755_abnormal_palate_morphology0.60999261
132MP0002092_abnormal_eye_morphology0.60905991
133MP0002089_abnormal_postnatal_growth/wei0.60762956
134MP0009703_decreased_birth_body0.60674876
135MP0003699_abnormal_female_reproductive0.60314965
136MP0002925_abnormal_cardiovascular_devel0.59655692
137MP0000678_abnormal_parathyroid_gland0.59268233
138MP0002429_abnormal_blood_cell0.57269185
139MP0002098_abnormal_vibrissa_morphology0.56923409

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)4.96176616
2Facial hemangioma (HP:0000329)4.47187371
3Rectovaginal fistula (HP:0000143)4.24613675
4Rectal fistula (HP:0100590)4.24613675
5Poikiloderma (HP:0001029)4.21813772
6Intestinal fistula (HP:0100819)4.06898622
7Annular pancreas (HP:0001734)3.98958380
8Pustule (HP:0200039)3.94127708
9Microvesicular hepatic steatosis (HP:0001414)3.77995703
10Hypochromic microcytic anemia (HP:0004840)3.73103403
11Progressive muscle weakness (HP:0003323)3.71375422
12Vaginal fistula (HP:0004320)3.68616309
13Selective tooth agenesis (HP:0001592)3.67146959
14Ulnar bowing (HP:0003031)3.63485589
15Short humerus (HP:0005792)3.56359385
16Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.54660031
17Tongue fasciculations (HP:0001308)3.53769638
18Aplasia/hypoplasia of the humerus (HP:0006507)3.50502341
19Basal cell carcinoma (HP:0002671)3.50205503
20Absent radius (HP:0003974)3.44508913
21Concave nail (HP:0001598)3.42921680
22Absent thumb (HP:0009777)3.34599805
23Abnormality of cells of the erythroid lineage (HP:0012130)3.31166373
24Volvulus (HP:0002580)3.30274497
25Squamous cell carcinoma (HP:0002860)3.29695469
26Muscle fibrillation (HP:0010546)3.26095225
27Aplasia involving forearm bones (HP:0009822)3.20714877
28Absent forearm bone (HP:0003953)3.20714877
29Alopecia of scalp (HP:0002293)3.20048425
30Ependymoma (HP:0002888)3.18626391
31Progressive external ophthalmoplegia (HP:0000590)3.16485624
32Reticulocytopenia (HP:0001896)3.16092394
33Abnormality of the astrocytes (HP:0100707)3.14376238
34Astrocytoma (HP:0009592)3.14376238
35Turricephaly (HP:0000262)3.10580235
36Patellar aplasia (HP:0006443)3.09264347
37Increased IgM level (HP:0003496)3.08065309
38Abnormality of the labia minora (HP:0012880)3.07723911
39Increased nuchal translucency (HP:0010880)3.03992809
40Abnormal number of erythroid precursors (HP:0012131)3.03857607
41Orthostatic hypotension (HP:0001278)3.02246699
42Multiple enchondromatosis (HP:0005701)3.01879425
43Intestinal atresia (HP:0011100)2.96592245
44Hyperacusis (HP:0010780)2.91045774
45Neoplasm of the oral cavity (HP:0100649)2.86499568
46Abnormality of the preputium (HP:0100587)2.85708592
47Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.85236014
48Vertebral hypoplasia (HP:0008417)2.85236014
49Aplasia/Hypoplasia of the patella (HP:0006498)2.81023414
50Congenital hip dislocation (HP:0001374)2.72367788
51Male infertility (HP:0003251)2.71407038
52Premature graying of hair (HP:0002216)2.70944652
53Abnormal hemoglobin (HP:0011902)2.69068075
54Abnormal gallbladder physiology (HP:0012438)2.68313118
55Cholecystitis (HP:0001082)2.68313118
56Proximal placement of thumb (HP:0009623)2.65444732
57Abnormal number of incisors (HP:0011064)2.64996333
58Insomnia (HP:0100785)2.64921077
59Abnormality of reticulocytes (HP:0004312)2.64608373
60Short chin (HP:0000331)2.63451922
61Abnormality of glycolysis (HP:0004366)2.59841190
62Deviation of the thumb (HP:0009603)2.58718623
63Overlapping toe (HP:0001845)2.57690143
64Coronal craniosynostosis (HP:0004440)2.54393697
65Cortical dysplasia (HP:0002539)2.53761212
66Broad alveolar ridges (HP:0000187)2.52252999
67Glioma (HP:0009733)2.50331038
68Abnormality of male internal genitalia (HP:0000022)2.50081747
69Albinism (HP:0001022)2.48923589
70Hypochromic anemia (HP:0001931)2.45197872
71Trismus (HP:0000211)2.44906662
72Abnormality of the ileum (HP:0001549)2.41455895
73Reticulocytosis (HP:0001923)2.40221205
74Medulloblastoma (HP:0002885)2.39647295
75Premature ovarian failure (HP:0008209)2.39620164
76Meckel diverticulum (HP:0002245)2.39338650
77Abnormality of chromosome stability (HP:0003220)2.38760000
78Hypotelorism (HP:0000601)2.37064779
79Anteriorly placed anus (HP:0001545)2.36766821
80High anterior hairline (HP:0009890)2.35908067
81IgA deficiency (HP:0002720)2.33055550
82Acute lymphatic leukemia (HP:0006721)2.29524088
83Nephroblastoma (Wilms tumor) (HP:0002667)2.28014903
84Cerebral aneurysm (HP:0004944)2.27926633
85Pancreatic islet-cell hyperplasia (HP:0004510)2.27446779
86Rhabdomyosarcoma (HP:0002859)2.26319957
87Deep philtrum (HP:0002002)2.26245241
88Spinal muscular atrophy (HP:0007269)2.26110408
89Dysautonomia (HP:0002459)2.23626265
90Urethral obstruction (HP:0000796)2.21499311
91Abnormality of the aortic arch (HP:0012303)2.19352767
92Vertebral fusion (HP:0002948)2.19071457
93Abnormality of the lower motor neuron (HP:0002366)2.18915761
94Macrocytic anemia (HP:0001972)2.15578292
95Abnormality of homocysteine metabolism (HP:0010919)2.14721625
96Homocystinuria (HP:0002156)2.14721625
97Horseshoe kidney (HP:0000085)2.14303530
98Premature skin wrinkling (HP:0100678)2.13307635
99Alacrima (HP:0000522)2.09966398
100Aplasia/Hypoplasia of the uvula (HP:0010293)2.09912401
101Hamartoma (HP:0010566)2.09728857
102Gastrointestinal atresia (HP:0002589)2.09163075
103Breast hypoplasia (HP:0003187)2.06846502
104Duodenal stenosis (HP:0100867)2.06239497
105Small intestinal stenosis (HP:0012848)2.06239497
106Hypoplasia of the radius (HP:0002984)2.04212583
107Increased serum pyruvate (HP:0003542)2.03948081
108Abnormality of the carotid arteries (HP:0005344)2.03167081
109Embryonal renal neoplasm (HP:0011794)2.03028583
110Ragged-red muscle fibers (HP:0003200)2.02492417
111Short thumb (HP:0009778)2.02049268
112Birth length less than 3rd percentile (HP:0003561)1.99744707
113Ankyloglossia (HP:0010296)1.99570493
114Capillary hemangiomas (HP:0005306)1.99552996
115Sparse lateral eyebrow (HP:0005338)1.97851531
116Upper limb muscle weakness (HP:0003484)1.97503363
117Increased number of teeth (HP:0011069)1.97309812
118Colon cancer (HP:0003003)1.96888679
119Bifid uvula (HP:0000193)1.96035109
120Overriding aorta (HP:0002623)1.95093340
121Abnormality of cochlea (HP:0000375)1.93260479
122Neoplasm of striated muscle (HP:0009728)1.93219765
123Choanal atresia (HP:0000453)1.92503532
124Bowed forearm bones (HP:0003956)1.92228177
125Bowing of the arm (HP:0006488)1.92228177
126Prominent nose (HP:0000448)1.91086497
127Myelodysplasia (HP:0002863)1.90267941
128Septate vagina (HP:0001153)1.89564342
129Chromosomal breakage induced by crosslinking agents (HP:0003221)1.88733272
130Impaired proprioception (HP:0010831)1.88722463
131Missing ribs (HP:0000921)1.88069381
132Acute myeloid leukemia (HP:0004808)1.87604344
133Pallor (HP:0000980)1.87493859
134Split hand (HP:0001171)1.86694333
135Long palpebral fissure (HP:0000637)1.86594279
136Heterotopia (HP:0002282)1.86424829
137Degeneration of anterior horn cells (HP:0002398)1.86263134
138Abnormality of the anterior horn cell (HP:0006802)1.86263134
139Large for gestational age (HP:0001520)1.84852691
140Hypoplasia of the capital femoral epiphysis (HP:0003090)1.84445988
141Dysmetric saccades (HP:0000641)1.84291568
142Chromsome breakage (HP:0040012)1.84181284
143Decreased lacrimation (HP:0000633)1.83831681
144Abnormality of abdominal situs (HP:0011620)1.83726544
145Abdominal situs inversus (HP:0003363)1.83726544
146Agnosia (HP:0010524)1.83446208
147Elfin facies (HP:0004428)1.82869666
148Diaphragmatic weakness (HP:0009113)1.82822613
149Abnormality of oral frenula (HP:0000190)1.81681586
150Impulsivity (HP:0100710)1.81222625
151Atresia of the external auditory canal (HP:0000413)1.79754798
152Hemivertebrae (HP:0002937)1.79634766
153Shawl scrotum (HP:0000049)1.79032266
154Cafe-au-lait spot (HP:0000957)1.78888712
155Aplasia/Hypoplasia of the sacrum (HP:0008517)1.78052650
156Mucopolysacchariduria (HP:0008155)1.77877716
157Secondary amenorrhea (HP:0000869)1.76222137
158Pointed chin (HP:0000307)1.74703051
159Obsessive-compulsive behavior (HP:0000722)1.73264869
160Progressive hearing impairment (HP:0001730)1.72629073
161Asymmetry of the thorax (HP:0001555)1.70897520
162Duplicated collecting system (HP:0000081)1.69157880
163Microglossia (HP:0000171)1.69108894
164Sandal gap (HP:0001852)1.68579044
165Partial agenesis of the corpus callosum (HP:0001338)1.67691552
166Rough bone trabeculation (HP:0100670)1.66896166
16711 pairs of ribs (HP:0000878)1.65621503
168Preauricular skin tag (HP:0000384)1.65095731
169Abnormality of the fingertips (HP:0001211)1.64873050
170Ectopic kidney (HP:0000086)1.64344756
171Pseudobulbar signs (HP:0002200)1.63674641
172Abnormal lung lobation (HP:0002101)1.62558398
173Spastic diplegia (HP:0001264)1.62314727
174Abnormality of chromosome segregation (HP:0002916)1.62272439
175Renal duplication (HP:0000075)1.61695249
176Breech presentation (HP:0001623)1.61195196
177Abnormality of DNA repair (HP:0003254)1.59966597
178Sloping forehead (HP:0000340)1.57630384
179Postnatal microcephaly (HP:0005484)1.57337623
180Abnormality of the salivary glands (HP:0010286)1.56575528
181Facial cleft (HP:0002006)1.56160464

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK5.29096890
2DDR23.94138983
3MAP3K63.87910135
4MAPK153.53046897
5SMG13.52601518
6MAP3K112.93262956
7VRK22.72538014
8TYRO32.49388738
9MATK2.43629319
10CDK122.32880589
11CDC72.25271126
12CDK72.24336504
13FGR2.15324988
14PINK12.12732799
15DAPK12.10019084
16PBK2.04927694
17BMX2.00688496
18PIM21.91649840
19TAF11.88846219
20WEE11.83183272
21CSK1.80551014
22CDK61.74820166
23PDGFRA1.72795419
24PIM11.65489423
25NEK21.62573743
26YES11.60692165
27PRKD21.59259116
28UHMK11.58484391
29PLK11.50107898
30MAP3K101.47280997
31EIF2AK31.44816271
32CHEK21.43939916
33DYRK1B1.42180816
34ATR1.33239217
35TTK1.33119822
36LATS21.32316533
37BUB11.31915121
38RPS6KB21.30551088
39NME11.29299212
40AKT31.27262765
41PLK41.27170005
42PLK31.26464303
43NEK11.23185770
44PRPF4B1.23063649
45IRAK31.19672899
46TRPM71.18979573
47EPHA21.17022836
48RPS6KC11.12021047
49RPS6KL11.12021047
50CDK41.11854069
51MTOR1.10313022
52EEF2K1.05870259
53EIF2AK21.02332406
54CDK80.99931732
55CLK10.98981416
56MST1R0.98728413
57ALK0.98502120
58DYRK30.97880936
59CHEK10.97391303
60RPS6KA60.96464754
61STK30.94337048
62BRSK10.92545168
63TAOK20.90596144
64CDK20.89651099
65AURKB0.89407354
66STK100.89216017
67MAPK110.88845837
68FGFR40.86375946
69CDC42BPA0.86343080
70VRK10.85114012
71ZAK0.83855402
72CDK90.82020867
73GSK3A0.79607215
74MAP4K10.77982558
75ATM0.74953484
76BRD40.74914388
77MAP3K90.71764594
78SIK10.70634381
79MST40.68966870
80TRIB30.68611135
81AURKA0.67808455
82RPS6KA40.67540289
83RPS6KA10.67353910
84MAP3K140.63591281
85MAP3K80.63267650
86TSSK60.60927420
87CAMK1D0.59624138
88TESK20.57072134
89SRPK10.55409987
90BRSK20.55267686
91CSNK2A20.55144320
92CDK10.55108785
93RPS6KB10.54244908
94PASK0.54182213
95CSNK2A10.53186593
96PRKAA10.52754952
97FLT30.51557963
98BRAF0.51506602
99PKN20.49896748
100PDK20.49754672
101RAF10.49178166
102STK160.48149952
103STK40.47584416
104MAP3K130.46750794
105ERN10.46098871
106HIPK20.45879631
107MAPK140.45650404
108MAPK10.44955446
109FGFR10.41584050
110PAK40.41557998
111PAK20.39511247
112MKNK20.39444541
113KSR20.39034183
114EGFR0.37765886
115TLK10.37397653
116EIF2AK10.37394172
117CDK30.36601450
118SCYL20.36575429
119CCNB10.36379566
120LATS10.36132661
121ERBB40.35842002
122ACVR1B0.35501657
123TAOK10.35497923
124MAPKAPK50.35440570
125MAPK100.35011451
126PHKG10.34021264
127PHKG20.34021264
128MAPK30.33912675
129PDGFRB0.33721914
130PRKDC0.33103543
131LYN0.32473083
132CSNK1E0.32410196
133PRKCI0.32145962
134MAP2K20.32136910
135MKNK10.32124491
136GSK3B0.31062002
137PAK10.30822328
138NME20.29957429
139CAMK1G0.29925345
140AKT20.28283903

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034305.15205066
2DNA replication_Homo sapiens_hsa030304.70972376
3Base excision repair_Homo sapiens_hsa034104.25610228
4Fatty acid biosynthesis_Homo sapiens_hsa000613.21312992
5* Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.09087763
6RNA transport_Homo sapiens_hsa030132.99891624
7Spliceosome_Homo sapiens_hsa030402.95341640
8Nucleotide excision repair_Homo sapiens_hsa034202.78949565
9Homologous recombination_Homo sapiens_hsa034402.50146659
10mRNA surveillance pathway_Homo sapiens_hsa030152.40374495
11One carbon pool by folate_Homo sapiens_hsa006702.36779737
12Fanconi anemia pathway_Homo sapiens_hsa034602.24067971
13Cell cycle_Homo sapiens_hsa041102.23127601
14Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.94736168
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.88357050
16p53 signaling pathway_Homo sapiens_hsa041151.74593040
17mTOR signaling pathway_Homo sapiens_hsa041501.59138387
18Biosynthesis of amino acids_Homo sapiens_hsa012301.55861113
19Ribosome_Homo sapiens_hsa030101.54436269
20Notch signaling pathway_Homo sapiens_hsa043301.49448137
21Carbon metabolism_Homo sapiens_hsa012001.48912562
22RNA polymerase_Homo sapiens_hsa030201.41840433
23Hippo signaling pathway_Homo sapiens_hsa043901.36222911
24RNA degradation_Homo sapiens_hsa030181.26777627
25Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.26372524
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.25216854
27Lysine degradation_Homo sapiens_hsa003101.22004800
28Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.18125228
29Hedgehog signaling pathway_Homo sapiens_hsa043401.17419495
30Transcriptional misregulation in cancer_Homo sapiens_hsa052021.16170163
31Adherens junction_Homo sapiens_hsa045201.14380714
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.10222234
33Pyrimidine metabolism_Homo sapiens_hsa002401.06740098
34Sulfur relay system_Homo sapiens_hsa041221.06219723
35Arginine and proline metabolism_Homo sapiens_hsa003301.06016230
36Non-homologous end-joining_Homo sapiens_hsa034501.05975529
37Pyruvate metabolism_Homo sapiens_hsa006201.03007117
38TGF-beta signaling pathway_Homo sapiens_hsa043501.02977566
39Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.02169368
40Oocyte meiosis_Homo sapiens_hsa041140.99956148
41Viral carcinogenesis_Homo sapiens_hsa052030.98989544
42Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.98596166
43Basal transcription factors_Homo sapiens_hsa030220.98111236
44Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.97136467
45Proteasome_Homo sapiens_hsa030500.96439038
46Circadian rhythm_Homo sapiens_hsa047100.95887915
47N-Glycan biosynthesis_Homo sapiens_hsa005100.95280507
48Bladder cancer_Homo sapiens_hsa052190.94569500
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.94259901
50MicroRNAs in cancer_Homo sapiens_hsa052060.91447590
51Primary immunodeficiency_Homo sapiens_hsa053400.90411945
52Folate biosynthesis_Homo sapiens_hsa007900.90249121
53Basal cell carcinoma_Homo sapiens_hsa052170.89740843
54Colorectal cancer_Homo sapiens_hsa052100.85689807
55Longevity regulating pathway - mammal_Homo sapiens_hsa042110.85598335
56Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.83213818
57Epstein-Barr virus infection_Homo sapiens_hsa051690.83107836
58Small cell lung cancer_Homo sapiens_hsa052220.78079115
59Herpes simplex infection_Homo sapiens_hsa051680.78073174
60Fructose and mannose metabolism_Homo sapiens_hsa000510.77013045
61Shigellosis_Homo sapiens_hsa051310.76976645
62Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.74906231
63Selenocompound metabolism_Homo sapiens_hsa004500.74736288
64Non-small cell lung cancer_Homo sapiens_hsa052230.74088528
65Wnt signaling pathway_Homo sapiens_hsa043100.73595499
66Pancreatic cancer_Homo sapiens_hsa052120.71615685
67Chronic myeloid leukemia_Homo sapiens_hsa052200.69643677
68Vitamin B6 metabolism_Homo sapiens_hsa007500.68969211
69Thyroid cancer_Homo sapiens_hsa052160.68890798
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.65569531
71HTLV-I infection_Homo sapiens_hsa051660.65348952
72Steroid biosynthesis_Homo sapiens_hsa001000.64043734
73Cyanoamino acid metabolism_Homo sapiens_hsa004600.63912557
74Acute myeloid leukemia_Homo sapiens_hsa052210.62373850
75Viral myocarditis_Homo sapiens_hsa054160.60332769
76Legionellosis_Homo sapiens_hsa051340.59142983
77Central carbon metabolism in cancer_Homo sapiens_hsa052300.58331167
78VEGF signaling pathway_Homo sapiens_hsa043700.56461684
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54503339
80Systemic lupus erythematosus_Homo sapiens_hsa053220.47973985
81Protein export_Homo sapiens_hsa030600.46081899
82Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.43632147
83Galactose metabolism_Homo sapiens_hsa000520.43018363
84Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42919414
85Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41739849
86Fatty acid metabolism_Homo sapiens_hsa012120.41001659
87Hepatitis B_Homo sapiens_hsa051610.39999378
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39230719
89AMPK signaling pathway_Homo sapiens_hsa041520.38050669
90Tight junction_Homo sapiens_hsa045300.37583804
91Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.37214400
92Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.36088316
93Fatty acid elongation_Homo sapiens_hsa000620.35135797
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33526250
95Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.33028806
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32933293
97Arginine biosynthesis_Homo sapiens_hsa002200.31924826
98Glioma_Homo sapiens_hsa052140.31644747
99Antigen processing and presentation_Homo sapiens_hsa046120.31319837
100Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.31239768
101HIF-1 signaling pathway_Homo sapiens_hsa040660.30400289
102Insulin signaling pathway_Homo sapiens_hsa049100.30018713
103Endometrial cancer_Homo sapiens_hsa052130.30018672
104Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.29984261
105Apoptosis_Homo sapiens_hsa042100.29770497
106Pentose phosphate pathway_Homo sapiens_hsa000300.29207051
107Proteoglycans in cancer_Homo sapiens_hsa052050.28787271
108Drug metabolism - other enzymes_Homo sapiens_hsa009830.27759733
109Measles_Homo sapiens_hsa051620.27615014
110Glycosaminoglycan degradation_Homo sapiens_hsa005310.27557637
111Pathways in cancer_Homo sapiens_hsa052000.27343343
112Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26887052
113Alcoholism_Homo sapiens_hsa050340.26533641
114Dorso-ventral axis formation_Homo sapiens_hsa043200.26074533
115Thyroid hormone signaling pathway_Homo sapiens_hsa049190.24951100
116ErbB signaling pathway_Homo sapiens_hsa040120.24949314
117Purine metabolism_Homo sapiens_hsa002300.24638400
118Renal cell carcinoma_Homo sapiens_hsa052110.23434834
119Prostate cancer_Homo sapiens_hsa052150.23218118
120Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.22733748
121PI3K-Akt signaling pathway_Homo sapiens_hsa041510.21694765
122B cell receptor signaling pathway_Homo sapiens_hsa046620.21653058
123Choline metabolism in cancer_Homo sapiens_hsa052310.20714202
124Metabolic pathways_Homo sapiens_hsa011000.18450840
125NF-kappa B signaling pathway_Homo sapiens_hsa040640.16782169
126Glutathione metabolism_Homo sapiens_hsa004800.16464918
127Huntingtons disease_Homo sapiens_hsa050160.16037769

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