

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 5.60980682 |
| 2 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 5.14544072 |
| 3 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 5.14002224 |
| 4 | axonemal dynein complex assembly (GO:0070286) | 5.13550251 |
| 5 | vocalization behavior (GO:0071625) | 5.02987784 |
| 6 | synaptic vesicle exocytosis (GO:0016079) | 4.99089830 |
| 7 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 4.94290587 |
| 8 | synaptic vesicle maturation (GO:0016188) | 4.86767063 |
| 9 | regulation of glutamate receptor signaling pathway (GO:1900449) | 4.68023545 |
| 10 | locomotory exploration behavior (GO:0035641) | 4.65434717 |
| 11 | glutamate secretion (GO:0014047) | 4.62110231 |
| 12 | neuron cell-cell adhesion (GO:0007158) | 4.60855487 |
| 13 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 4.59351885 |
| 14 | protein localization to synapse (GO:0035418) | 4.51953783 |
| 15 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 4.51364891 |
| 16 | regulation of synaptic vesicle exocytosis (GO:2000300) | 4.47725080 |
| 17 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 4.31330717 |
| 18 | regulation of neuronal synaptic plasticity (GO:0048168) | 4.28407841 |
| 19 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 4.21277787 |
| 20 | glutamate receptor signaling pathway (GO:0007215) | 4.20370106 |
| 21 | regulation of synaptic vesicle transport (GO:1902803) | 4.15855667 |
| 22 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 4.15005446 |
| 23 | motile cilium assembly (GO:0044458) | 4.13610632 |
| 24 | left/right pattern formation (GO:0060972) | 4.07966892 |
| 25 | synaptic transmission, glutamatergic (GO:0035249) | 4.07699296 |
| 26 | neurotransmitter-gated ion channel clustering (GO:0072578) | 4.03663832 |
| 27 | long-term memory (GO:0007616) | 3.95679781 |
| 28 | neuronal action potential propagation (GO:0019227) | 3.94534338 |
| 29 | neuron-neuron synaptic transmission (GO:0007270) | 3.92908723 |
| 30 | regulation of synapse structural plasticity (GO:0051823) | 3.92349313 |
| 31 | neurotransmitter secretion (GO:0007269) | 3.90216949 |
| 32 | exploration behavior (GO:0035640) | 3.90027932 |
| 33 | sensory perception of smell (GO:0007608) | 3.88969313 |
| 34 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.86224369 |
| 35 | viral transcription (GO:0019083) | 3.75918965 |
| 36 | neuron recognition (GO:0008038) | 3.75493016 |
| 37 | planar cell polarity pathway involved in neural tube closure (GO:0090179) | 3.73569523 |
| 38 | cellular potassium ion homeostasis (GO:0030007) | 3.70043937 |
| 39 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 3.65291722 |
| 40 | cell migration in hindbrain (GO:0021535) | 3.63332978 |
| 41 | positive regulation of synapse maturation (GO:0090129) | 3.60772620 |
| 42 | regulation of synaptic plasticity (GO:0048167) | 3.58276716 |
| 43 | activation of protein kinase A activity (GO:0034199) | 3.54049025 |
| 44 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 3.52164384 |
| 45 | regulation of postsynaptic membrane potential (GO:0060078) | 3.50976570 |
| 46 | detection of calcium ion (GO:0005513) | 3.49781409 |
| 47 | translational termination (GO:0006415) | 3.49346074 |
| 48 | layer formation in cerebral cortex (GO:0021819) | 3.49270116 |
| 49 | positive regulation of membrane potential (GO:0045838) | 3.49150422 |
| 50 | behavioral fear response (GO:0001662) | 3.47534833 |
| 51 | behavioral defense response (GO:0002209) | 3.47534833 |
| 52 | cilium movement (GO:0003341) | 3.45354592 |
| 53 | behavioral response to cocaine (GO:0048148) | 3.44958885 |
| 54 | regulation of female receptivity (GO:0045924) | 3.44883545 |
| 55 | adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191) | 3.43514833 |
| 56 | ribosomal small subunit biogenesis (GO:0042274) | 3.43457825 |
| 57 | long-term synaptic potentiation (GO:0060291) | 3.42569050 |
| 58 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 3.41876413 |
| 59 | lung epithelium development (GO:0060428) | 3.40090886 |
| 60 | dendritic spine morphogenesis (GO:0060997) | 3.39101598 |
| 61 | female mating behavior (GO:0060180) | 3.38564807 |
| 62 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 3.38033934 |
| 63 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 3.36842550 |
| 64 | axon extension involved in axon guidance (GO:0048846) | 3.36775533 |
| 65 | neuron projection extension involved in neuron projection guidance (GO:1902284) | 3.36775533 |
| 66 | gamma-aminobutyric acid transport (GO:0015812) | 3.34912397 |
| 67 | positive regulation of neurotransmitter secretion (GO:0001956) | 3.34730726 |
| 68 | axonal fasciculation (GO:0007413) | 3.33284918 |
| 69 | regulation of establishment of planar polarity involved in neural tube closure (GO:0090178) | 3.31879818 |
| 70 | regulation of dendritic spine morphogenesis (GO:0061001) | 3.31335513 |
| 71 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.30503938 |
| 72 | positive regulation of neurotransmitter transport (GO:0051590) | 3.30188288 |
| 73 | transmission of nerve impulse (GO:0019226) | 3.29906803 |
| 74 | synaptic vesicle endocytosis (GO:0048488) | 3.29111239 |
| 75 | fear response (GO:0042596) | 3.26046381 |
| 76 | proline transport (GO:0015824) | 3.23481843 |
| 77 | axon extension (GO:0048675) | 3.23235717 |
| 78 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 3.22894995 |
| 79 | dopamine receptor signaling pathway (GO:0007212) | 3.22491711 |
| 80 | neurotransmitter transport (GO:0006836) | 3.21114936 |
| 81 | regulation of vesicle fusion (GO:0031338) | 3.19401289 |
| 82 | regulation of glutamate secretion (GO:0014048) | 3.19335812 |
| 83 | establishment of monopolar cell polarity (GO:0061162) | 3.19329863 |
| 84 | establishment or maintenance of monopolar cell polarity (GO:0061339) | 3.19329863 |
| 85 | regulation of neurotransmitter secretion (GO:0046928) | 3.18534918 |
| 86 | convergent extension (GO:0060026) | 3.17219907 |
| 87 | striatum development (GO:0021756) | 3.13296084 |
| 88 | camera-type eye morphogenesis (GO:0048593) | 3.13120436 |
| 89 | G-protein coupled acetylcholine receptor signaling pathway (GO:0007213) | 3.11692603 |
| 90 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 3.07582416 |
| 91 | mating behavior (GO:0007617) | 3.06266361 |
| 92 | epithelial cilium movement (GO:0003351) | 3.06205708 |
| 93 | positive regulation of synaptic transmission (GO:0050806) | 3.06060219 |
| 94 | regulation of neurotransmitter transport (GO:0051588) | 3.05726218 |
| 95 | learning (GO:0007612) | 3.04398482 |
| 96 | postsynaptic membrane organization (GO:0001941) | 3.04013032 |
| 97 | response to auditory stimulus (GO:0010996) | 3.03274832 |
| 98 | membrane depolarization during action potential (GO:0086010) | 3.03231505 |
| 99 | negative regulation of catenin import into nucleus (GO:0035414) | 3.02669691 |
| 100 | regulation of synapse maturation (GO:0090128) | 3.02624466 |
| 101 | positive regulation of dendritic spine development (GO:0060999) | 3.02156402 |
| 102 | membrane depolarization (GO:0051899) | 3.02071438 |
| 103 | regulation of synaptic transmission, GABAergic (GO:0032228) | 3.01989916 |
| 104 | auditory behavior (GO:0031223) | 3.01682862 |
| 105 | response to amphetamine (GO:0001975) | 3.01644723 |
| 106 | membrane hyperpolarization (GO:0060081) | 3.01367966 |
| 107 | synaptic transmission (GO:0007268) | 3.00317599 |
| 108 | regulation of synaptic transmission (GO:0050804) | 2.97381784 |
| 109 | regulation of neurotransmitter levels (GO:0001505) | 2.97029825 |
| 110 | translational elongation (GO:0006414) | 2.96694936 |
| 111 | negative regulation of cytosolic calcium ion concentration (GO:0051481) | 2.96169374 |
| 112 | synaptic transmission, dopaminergic (GO:0001963) | 2.96054784 |
| 113 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 2.95691652 |
| 114 | neuronal ion channel clustering (GO:0045161) | 2.94580898 |
| 115 | protein retention in ER lumen (GO:0006621) | 2.94232171 |
| 116 | establishment of mitochondrion localization (GO:0051654) | 2.92652186 |
| 117 | cellular protein complex disassembly (GO:0043624) | 2.92087047 |
| 118 | innervation (GO:0060384) | 2.90402178 |
| 119 | prepulse inhibition (GO:0060134) | 2.89927410 |
| 120 | regulation of dopamine uptake involved in synaptic transmission (GO:0051584) | 2.89674920 |
| 121 | regulation of catecholamine uptake involved in synaptic transmission (GO:0051940) | 2.89674920 |
| 122 | neuromuscular process controlling balance (GO:0050885) | 2.89386184 |
| 123 | response to histamine (GO:0034776) | 2.87779767 |
| 124 | cerebellar Purkinje cell differentiation (GO:0021702) | 2.87384270 |
| 125 | regulation of dendritic spine development (GO:0060998) | 2.87125439 |
| 126 | body morphogenesis (GO:0010171) | 2.86098859 |
| 127 | cilium or flagellum-dependent cell motility (GO:0001539) | 2.83520314 |
| 128 | neuron projection extension (GO:1990138) | 2.81700282 |
| 129 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 2.80765865 |
| 130 | epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287) | 2.78756825 |
| 131 | establishment of apical/basal cell polarity (GO:0035089) | 2.78537390 |
| 132 | protein complex disassembly (GO:0043241) | 2.78225575 |
| 133 | viral life cycle (GO:0019058) | 2.76722306 |
| 134 | establishment of mitochondrion localization, microtubule-mediated (GO:0034643) | 2.76491359 |
| 135 | mitochondrion transport along microtubule (GO:0047497) | 2.76491359 |
| 136 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 2.75861951 |
| 137 | cotranslational protein targeting to membrane (GO:0006613) | 2.72470875 |
| 138 | protein targeting to ER (GO:0045047) | 2.72184340 |
| 139 | ribosomal small subunit assembly (GO:0000028) | 2.69844621 |
| 140 | cell-cell junction maintenance (GO:0045217) | 2.69436599 |
| 141 | lens fiber cell development (GO:0070307) | 2.67939117 |
| 142 | microtubule bundle formation (GO:0001578) | 2.66031394 |
| 143 | Wnt signaling pathway, planar cell polarity pathway (GO:0060071) | 2.65796535 |
| 144 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 2.63325890 |
| 145 | establishment of tissue polarity (GO:0007164) | 2.62883523 |
| 146 | establishment of planar polarity (GO:0001736) | 2.62883523 |
| 147 | protein insertion into membrane (GO:0051205) | 2.62741772 |
| 148 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 2.60481847 |
| 149 | pyrimidine nucleobase catabolic process (GO:0006208) | 2.60113625 |
| 150 | substrate-independent telencephalic tangential migration (GO:0021826) | 2.60063039 |
| 151 | substrate-independent telencephalic tangential interneuron migration (GO:0021843) | 2.60063039 |
| 152 | central nervous system myelination (GO:0022010) | 2.59738453 |
| 153 | axon ensheathment in central nervous system (GO:0032291) | 2.59738453 |
| 154 | macromolecular complex disassembly (GO:0032984) | 2.56560739 |
| 155 | maintenance of protein localization in endoplasmic reticulum (GO:0035437) | 2.55772301 |
| 156 | protein localization to endoplasmic reticulum (GO:0070972) | 2.54923431 |
| 157 | intraciliary transport (GO:0042073) | 2.52045206 |
| 158 | regulation of establishment of planar polarity (GO:0090175) | 2.45105975 |
| 159 | regulation of glycogen (starch) synthase activity (GO:2000465) | 2.44667209 |
| 160 | cochlea morphogenesis (GO:0090103) | 2.42618864 |
| 161 | presynaptic membrane organization (GO:0097090) | 2.42246571 |
| 162 | heterochromatin organization (GO:0070828) | 2.42027267 |
| 163 | L-serine metabolic process (GO:0006563) | 2.41402762 |
| 164 | skeletal muscle organ development (GO:0060538) | 2.41226682 |
| 165 | cranial nerve morphogenesis (GO:0021602) | 2.41160168 |
| 166 | cerebellar Purkinje cell layer development (GO:0021680) | 2.36955542 |
| 167 | cerebellar granule cell differentiation (GO:0021707) | 2.36103950 |
| 168 | positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling | 2.35946842 |
| 169 | embryonic body morphogenesis (GO:0010172) | 2.35455445 |
| 170 | regulation of mammary gland epithelial cell proliferation (GO:0033599) | 2.33920017 |
| 171 | apical protein localization (GO:0045176) | 2.30885234 |
| 172 | presynaptic membrane assembly (GO:0097105) | 2.26596139 |
| 173 | G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:0007199 | 2.26467832 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 6.22739822 |
| 2 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 5.15508264 |
| 3 | GBX2_23144817_ChIP-Seq_PC3_Human | 3.83130811 |
| 4 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 3.10059760 |
| 5 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 3.06923586 |
| 6 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 3.01810623 |
| 7 | REST_21632747_ChIP-Seq_MESCs_Mouse | 2.69322808 |
| 8 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.69072429 |
| 9 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.69072429 |
| 10 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.66556244 |
| 11 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.65370063 |
| 12 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.53569865 |
| 13 | * SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.52005855 |
| 14 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.51657274 |
| 15 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 2.51339327 |
| 16 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.48103219 |
| 17 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.42968199 |
| 18 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.38512023 |
| 19 | LXR_22292898_ChIP-Seq_THP-1_Human | 2.36203247 |
| 20 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.34240020 |
| 21 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.30456048 |
| 22 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 2.28370620 |
| 23 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.24815292 |
| 24 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.18978694 |
| 25 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 2.14526036 |
| 26 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 2.11946386 |
| 27 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 2.11034037 |
| 28 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 2.06094404 |
| 29 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 2.01442072 |
| 30 | CTCF_27219007_Chip-Seq_Bcells_Human | 1.92735948 |
| 31 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.82131177 |
| 32 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.77797504 |
| 33 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.76310548 |
| 34 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.74949101 |
| 35 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 1.74571806 |
| 36 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.73981154 |
| 37 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.73469248 |
| 38 | * P68_20966046_ChIP-Seq_HELA_Human | 1.72332291 |
| 39 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.72105801 |
| 40 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.70314856 |
| 41 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.69162969 |
| 42 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.65110115 |
| 43 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.65076955 |
| 44 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.63385969 |
| 45 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 1.63106715 |
| 46 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.62631686 |
| 47 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.61356466 |
| 48 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.60502894 |
| 49 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.59806621 |
| 50 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.59418599 |
| 51 | OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 1.59364747 |
| 52 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.58771351 |
| 53 | * KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.57584039 |
| 54 | * SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.55575063 |
| 55 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.54543149 |
| 56 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.53786225 |
| 57 | P300_19829295_ChIP-Seq_ESCs_Human | 1.53029913 |
| 58 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 1.53009727 |
| 59 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.52819817 |
| 60 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.52576237 |
| 61 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.52123420 |
| 62 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 1.50400991 |
| 63 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.49511902 |
| 64 | UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 1.47399390 |
| 65 | RACK7_27058665_Chip-Seq_MCF-7_Human | 1.46517031 |
| 66 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.42626298 |
| 67 | * SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.41627097 |
| 68 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 1.41241871 |
| 69 | CREB1_26743006_Chip-Seq_LNCaP_Human | 1.41085015 |
| 70 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.39725041 |
| 71 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.39622383 |
| 72 | * ZFP281_27345836_Chip-Seq_ESCs_Mouse | 1.39548639 |
| 73 | MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human | 1.39536525 |
| 74 | SMC4_20622854_ChIP-Seq_HELA_Human | 1.38630307 |
| 75 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.37845011 |
| 76 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 1.36906013 |
| 77 | SA1_27219007_Chip-Seq_ERYTHROID_Human | 1.35480401 |
| 78 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.34143551 |
| 79 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.33985170 |
| 80 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.33694670 |
| 81 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.31948568 |
| 82 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.30829603 |
| 83 | TP53_22127205_ChIP-Seq_IMR90_Human | 1.30346373 |
| 84 | * CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.29962438 |
| 85 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.29864502 |
| 86 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.29682626 |
| 87 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.29447007 |
| 88 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.28267038 |
| 89 | VDR_22108803_ChIP-Seq_LS180_Human | 1.27512522 |
| 90 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.24625404 |
| 91 | FOXP1_21924763_ChIP-Seq_HESCs_Human | 1.24521143 |
| 92 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.23617123 |
| 93 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.23046031 |
| 94 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.22902634 |
| 95 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.21602652 |
| 96 | SETDB1_19884255_ChIP-Seq_MESCs_Mouse | 1.21270770 |
| 97 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.20845138 |
| 98 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.20177952 |
| 99 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 1.20169857 |
| 100 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.19140749 |
| 101 | AR_25329375_ChIP-Seq_VCAP_Human | 1.19032866 |
| 102 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.18209937 |
| 103 | TET1_21490601_ChIP-Seq_MESCs_Mouse | 1.18040441 |
| 104 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.16403292 |
| 105 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.15785406 |
| 106 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.15645787 |
| 107 | STAT3_23295773_ChIP-Seq_U87_Human | 1.15343692 |
| 108 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.14550498 |
| 109 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 1.13434843 |
| 110 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.13354100 |
| 111 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.12476366 |
| 112 | CTCF_27219007_Chip-Seq_ERYTHROID_Human | 1.11179721 |
| 113 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.10575170 |
| 114 | AR_19668381_ChIP-Seq_PC3_Human | 1.10537412 |
| 115 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.10378656 |
| 116 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.09928445 |
| 117 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 1.09501490 |
| 118 | * SOX3_22085726_ChIP-Seq_NPCs_Mouse | 1.08996899 |
| 119 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.07633752 |
| 120 | PHF8_20622854_ChIP-Seq_HELA_Human | 1.07083161 |
| 121 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.07024270 |
| 122 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.06665067 |
| 123 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.06659540 |
| 124 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.06646563 |
| 125 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 1.06598971 |
| 126 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 1.06275447 |
| 127 | SMAD2/3_21741376_ChIP-Seq_ESCs_Human | 1.06106243 |
| 128 | RARA_24833708_ChIP-Seq_LIVER_Mouse | 1.05528621 |
| 129 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.05201494 |
| 130 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.04920756 |
| 131 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.04892343 |
| 132 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.04726714 |
| 133 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.04567009 |
| 134 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.03474370 |
| 135 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.02353249 |
| 136 | RUNX2_22187159_ChIP-Seq_PCA_Human | 1.02030981 |
| 137 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.01943881 |
| 138 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.99181537 |
| 139 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 0.98167152 |
| 140 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.98167152 |
| 141 | TCF4_23295773_ChIP-Seq_U87_Human | 0.98104344 |
| 142 | AHR_22903824_ChIP-Seq_MCF-7_Human | 0.96293074 |
| 143 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 0.95250081 |
| 144 | FUS_26573619_Chip-Seq_HEK293_Human | 0.94865249 |
| 145 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 0.94641212 |
| 146 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.94267620 |
| 147 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 0.94114902 |
| 148 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 0.93948921 |
| 149 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.93716273 |
| 150 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 0.93284256 |
| 151 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 0.92419691 |
| 152 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 0.91883011 |
| 153 | JUN_21703547_ChIP-Seq_K562_Human | 0.91732990 |
| 154 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 0.90842062 |
| 155 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.89615069 |
| 156 | KDM2B_26808549_Chip-Seq_K562_Human | 0.88862212 |
| 157 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 0.86546080 |
| 158 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 0.86396239 |
| 159 | * EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 0.84952656 |
| 160 | SMAD4_21741376_ChIP-Seq_EPCs_Human | 0.84902804 |
| 161 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 0.84742355 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 6.09284854 |
| 2 | MP0003880_abnormal_central_pattern | 4.98782860 |
| 3 | MP0003635_abnormal_synaptic_transmissio | 3.98786481 |
| 4 | MP0010030_abnormal_orbit_morphology | 3.73088329 |
| 5 | MP0001984_abnormal_olfaction | 3.64579577 |
| 6 | MP0004270_analgesia | 3.35865148 |
| 7 | MP0002063_abnormal_learning/memory/cond | 3.35697584 |
| 8 | MP0009745_abnormal_behavioral_response | 3.35125588 |
| 9 | MP0002822_catalepsy | 3.25738730 |
| 10 | MP0001968_abnormal_touch/_nociception | 3.04160436 |
| 11 | MP0009379_abnormal_foot_pigmentation | 3.01484306 |
| 12 | MP0002064_seizures | 2.99430097 |
| 13 | MP0003123_paternal_imprinting | 2.90392093 |
| 14 | MP0002572_abnormal_emotion/affect_behav | 2.85192109 |
| 15 | MP0009046_muscle_twitch | 2.66134954 |
| 16 | MP0002272_abnormal_nervous_system | 2.58312186 |
| 17 | MP0001486_abnormal_startle_reflex | 2.52917312 |
| 18 | MP0002734_abnormal_mechanical_nocicepti | 2.52170308 |
| 19 | MP0005423_abnormal_somatic_nervous | 2.51391744 |
| 20 | MP0002736_abnormal_nociception_after | 2.46329373 |
| 21 | MP0002735_abnormal_chemical_nociception | 2.40667899 |
| 22 | MP0000566_synostosis | 2.33189892 |
| 23 | MP0001501_abnormal_sleep_pattern | 2.25510743 |
| 24 | MP0005623_abnormal_meninges_morphology | 2.16401699 |
| 25 | MP0001346_abnormal_lacrimal_gland | 2.10538439 |
| 26 | MP0002249_abnormal_larynx_morphology | 2.10531763 |
| 27 | MP0001440_abnormal_grooming_behavior | 2.06934400 |
| 28 | MP0001970_abnormal_pain_threshold | 2.01467101 |
| 29 | MP0006276_abnormal_autonomic_nervous | 1.97235376 |
| 30 | MP0002184_abnormal_innervation | 1.96948194 |
| 31 | MP0005646_abnormal_pituitary_gland | 1.95183796 |
| 32 | MP0005645_abnormal_hypothalamus_physiol | 1.92547637 |
| 33 | MP0002733_abnormal_thermal_nociception | 1.89022846 |
| 34 | MP0002557_abnormal_social/conspecific_i | 1.85602342 |
| 35 | MP0002067_abnormal_sensory_capabilities | 1.84830643 |
| 36 | MP0001529_abnormal_vocalization | 1.79908822 |
| 37 | MP0003942_abnormal_urinary_system | 1.79239414 |
| 38 | MP0010386_abnormal_urinary_bladder | 1.77043860 |
| 39 | MP0004133_heterotaxia | 1.75721494 |
| 40 | MP0000778_abnormal_nervous_system | 1.73385565 |
| 41 | MP0000049_abnormal_middle_ear | 1.71288672 |
| 42 | MP0003329_amyloid_beta_deposits | 1.71271463 |
| 43 | MP0005257_abnormal_intraocular_pressure | 1.68771143 |
| 44 | MP0004924_abnormal_behavior | 1.61128379 |
| 45 | MP0005386_behavior/neurological_phenoty | 1.61128379 |
| 46 | MP0003879_abnormal_hair_cell | 1.60419008 |
| 47 | MP0004811_abnormal_neuron_physiology | 1.58939364 |
| 48 | MP0003136_yellow_coat_color | 1.58713795 |
| 49 | MP0002909_abnormal_adrenal_gland | 1.55462449 |
| 50 | MP0004858_abnormal_nervous_system | 1.54636423 |
| 51 | MP0009053_abnormal_anal_canal | 1.51616861 |
| 52 | MP0001905_abnormal_dopamine_level | 1.46958985 |
| 53 | MP0002882_abnormal_neuron_morphology | 1.46208163 |
| 54 | MP0005499_abnormal_olfactory_system | 1.45663839 |
| 55 | MP0005394_taste/olfaction_phenotype | 1.45663839 |
| 56 | MP0001502_abnormal_circadian_rhythm | 1.45448322 |
| 57 | MP0008569_lethality_at_weaning | 1.43705775 |
| 58 | MP0001188_hyperpigmentation | 1.41755402 |
| 59 | MP0000955_abnormal_spinal_cord | 1.41545933 |
| 60 | MP0003787_abnormal_imprinting | 1.35270472 |
| 61 | MP0003705_abnormal_hypodermis_morpholog | 1.32967395 |
| 62 | MP0003121_genomic_imprinting | 1.32783686 |
| 63 | MP0009780_abnormal_chondrocyte_physiolo | 1.32691154 |
| 64 | MP0002066_abnormal_motor_capabilities/c | 1.31890360 |
| 65 | MP0001293_anophthalmia | 1.31445458 |
| 66 | MP0000678_abnormal_parathyroid_gland | 1.26756864 |
| 67 | MP0004885_abnormal_endolymph | 1.24271239 |
| 68 | MP0005551_abnormal_eye_electrophysiolog | 1.22312464 |
| 69 | MP0001299_abnormal_eye_distance/ | 1.21670387 |
| 70 | MP0000534_abnormal_ureter_morphology | 1.21470043 |
| 71 | MP0003938_abnormal_ear_development | 1.20616136 |
| 72 | MP0000537_abnormal_urethra_morphology | 1.19664483 |
| 73 | MP0003385_abnormal_body_wall | 1.19488108 |
| 74 | MP0001348_abnormal_lacrimal_gland | 1.19134803 |
| 75 | MP0003633_abnormal_nervous_system | 1.15033344 |
| 76 | MP0002116_abnormal_craniofacial_bone | 1.14963096 |
| 77 | MP0002233_abnormal_nose_morphology | 1.14282217 |
| 78 | MP0005248_abnormal_Harderian_gland | 1.13751403 |
| 79 | MP0002152_abnormal_brain_morphology | 1.08453029 |
| 80 | MP0002697_abnormal_eye_size | 1.07455875 |
| 81 | MP0009250_abnormal_appendicular_skeleto | 1.05970909 |
| 82 | MP0004142_abnormal_muscle_tone | 1.05852905 |
| 83 | MP0003122_maternal_imprinting | 1.04870849 |
| 84 | MP0002160_abnormal_reproductive_system | 1.04287632 |
| 85 | MP0003937_abnormal_limbs/digits/tail_de | 1.04252001 |
| 86 | MP0002163_abnormal_gland_morphology | 1.02693003 |
| 87 | MP0003119_abnormal_digestive_system | 1.01172817 |
| 88 | MP0002089_abnormal_postnatal_growth/wei | 0.99955699 |
| 89 | MP0002938_white_spotting | 0.99764933 |
| 90 | MP0002092_abnormal_eye_morphology | 0.98917119 |
| 91 | MP0006292_abnormal_olfactory_placode | 0.98084568 |
| 92 | MP0003631_nervous_system_phenotype | 0.96973487 |
| 93 | MP0008789_abnormal_olfactory_epithelium | 0.96555453 |
| 94 | MP0002752_abnormal_somatic_nervous | 0.96493476 |
| 95 | MP0001485_abnormal_pinna_reflex | 0.95402384 |
| 96 | MP0002229_neurodegeneration | 0.94580655 |
| 97 | MP0008872_abnormal_physiological_respon | 0.94362725 |
| 98 | MP0001849_ear_inflammation | 0.93185803 |
| 99 | MP0003755_abnormal_palate_morphology | 0.91903371 |
| 100 | MP0002069_abnormal_eating/drinking_beha | 0.91017760 |
| 101 | MP0001963_abnormal_hearing_physiology | 0.90832595 |
| 102 | MP0000751_myopathy | 0.89812677 |
| 103 | MP0001286_abnormal_eye_development | 0.89505561 |
| 104 | MP0004742_abnormal_vestibular_system | 0.89335440 |
| 105 | MP0004145_abnormal_muscle_electrophysio | 0.88576578 |
| 106 | MP0008874_decreased_physiological_sensi | 0.86374310 |
| 107 | MP0002638_abnormal_pupillary_reflex | 0.86293498 |
| 108 | MP0000631_abnormal_neuroendocrine_gland | 0.84347888 |
| 109 | MP0002837_dystrophic_cardiac_calcinosis | 0.84323649 |
| 110 | MP0002081_perinatal_lethality | 0.84208534 |
| 111 | MP0000428_abnormal_craniofacial_morphol | 0.83523263 |
| 112 | MP0005535_abnormal_body_temperature | 0.82292239 |
| 113 | MP0003075_altered_response_to | 0.80381858 |
| 114 | MP0004085_abnormal_heartbeat | 0.79179446 |
| 115 | MP0003634_abnormal_glial_cell | 0.78658091 |
| 116 | MP0000013_abnormal_adipose_tissue | 0.78552806 |
| 117 | MP0003878_abnormal_ear_physiology | 0.76764839 |
| 118 | MP0005377_hearing/vestibular/ear_phenot | 0.76764839 |
| 119 | MP0006072_abnormal_retinal_apoptosis | 0.76059776 |
| 120 | MP0002932_abnormal_joint_morphology | 0.76020447 |
| 121 | MP0009384_cardiac_valve_regurgitation | 0.73719683 |
| 122 | MP0002876_abnormal_thyroid_physiology | 0.73464628 |
| 123 | MP0004484_altered_response_of | 0.72495990 |
| 124 | MP0004215_abnormal_myocardial_fiber | 0.69624335 |
| 125 | MP0000604_amyloidosis | 0.69559131 |
| 126 | MP0000026_abnormal_inner_ear | 0.69179332 |
| 127 | MP0001664_abnormal_digestion | 0.69043747 |
| 128 | MP0005409_darkened_coat_color | 0.68631252 |
| 129 | MP0001177_atelectasis | 0.67384643 |
| 130 | MP0003646_muscle_fatigue | 0.66402127 |
| 131 | MP0002653_abnormal_ependyma_morphology | 0.62904934 |
| 132 | MP0002234_abnormal_pharynx_morphology | 0.62750089 |
| 133 | MP0002102_abnormal_ear_morphology | 0.59303556 |
| 134 | MP0002090_abnormal_vision | 0.58986880 |
| 135 | MP0005167_abnormal_blood-brain_barrier | 0.58269579 |
| 136 | MP0003632_abnormal_nervous_system | 0.58117411 |
| 137 | MP0008961_abnormal_basal_metabolism | 0.57388913 |
| 138 | MP0003137_abnormal_impulse_conducting | 0.56195900 |
| 139 | MP0003861_abnormal_nervous_system | 0.54660217 |
| 140 | MP0004510_myositis | 0.54231879 |
| 141 | MP0001986_abnormal_taste_sensitivity | 0.53019956 |
| 142 | MP0003283_abnormal_digestive_organ | 0.52585352 |
| 143 | MP0003690_abnormal_glial_cell | 0.51836184 |
| 144 | MP0005253_abnormal_eye_physiology | 0.49051262 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Focal motor seizures (HP:0011153) | 7.47386808 |
| 2 | Myokymia (HP:0002411) | 7.01600412 |
| 3 | Focal seizures (HP:0007359) | 5.59513511 |
| 4 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 5.31995710 |
| 5 | Atonic seizures (HP:0010819) | 5.20871279 |
| 6 | Febrile seizures (HP:0002373) | 5.14329484 |
| 7 | Epileptic encephalopathy (HP:0200134) | 4.68158705 |
| 8 | Visual hallucinations (HP:0002367) | 4.64752709 |
| 9 | Absence seizures (HP:0002121) | 4.29709375 |
| 10 | Dialeptic seizures (HP:0011146) | 3.91224828 |
| 11 | Generalized tonic-clonic seizures (HP:0002069) | 3.90716455 |
| 12 | Rhinitis (HP:0012384) | 3.80101453 |
| 13 | Progressive cerebellar ataxia (HP:0002073) | 3.55506112 |
| 14 | Retinal dysplasia (HP:0007973) | 3.51784184 |
| 15 | Action tremor (HP:0002345) | 3.29712291 |
| 16 | Hyperventilation (HP:0002883) | 3.13359217 |
| 17 | Supranuclear gaze palsy (HP:0000605) | 3.10563569 |
| 18 | Chronic bronchitis (HP:0004469) | 3.08346276 |
| 19 | Depression (HP:0000716) | 3.06738667 |
| 20 | Anxiety (HP:0000739) | 3.02485040 |
| 21 | Amblyopia (HP:0000646) | 3.01728480 |
| 22 | Broad-based gait (HP:0002136) | 2.98774515 |
| 23 | Ankle clonus (HP:0011448) | 2.97389606 |
| 24 | Gait imbalance (HP:0002141) | 2.96312490 |
| 25 | Poor eye contact (HP:0000817) | 2.93835336 |
| 26 | Torticollis (HP:0000473) | 2.91443072 |
| 27 | Abnormality of the aortic arch (HP:0012303) | 2.90336866 |
| 28 | Limb dystonia (HP:0002451) | 2.86778315 |
| 29 | Abnormal eating behavior (HP:0100738) | 2.84922737 |
| 30 | Impaired vibration sensation in the lower limbs (HP:0002166) | 2.80252894 |
| 31 | Dysmetria (HP:0001310) | 2.77184403 |
| 32 | Focal dystonia (HP:0004373) | 2.75850262 |
| 33 | Atelectasis (HP:0100750) | 2.72739714 |
| 34 | Truncal ataxia (HP:0002078) | 2.68207411 |
| 35 | Hyperthyroidism (HP:0000836) | 2.67424704 |
| 36 | Congenital primary aphakia (HP:0007707) | 2.67303619 |
| 37 | Turricephaly (HP:0000262) | 2.62670406 |
| 38 | Medial flaring of the eyebrow (HP:0010747) | 2.62644237 |
| 39 | Gaze-evoked nystagmus (HP:0000640) | 2.58078326 |
| 40 | Hyperacusis (HP:0010780) | 2.56683286 |
| 41 | Dysdiadochokinesis (HP:0002075) | 2.54184022 |
| 42 | Impaired social interactions (HP:0000735) | 2.53970671 |
| 43 | Abnormal social behavior (HP:0012433) | 2.53970671 |
| 44 | Broad distal phalanx of finger (HP:0009836) | 2.53133458 |
| 45 | Cerebral inclusion bodies (HP:0100314) | 2.50865730 |
| 46 | Nephrogenic diabetes insipidus (HP:0009806) | 2.49609730 |
| 47 | Craniofacial dystonia (HP:0012179) | 2.48587591 |
| 48 | Epileptiform EEG discharges (HP:0011182) | 2.45863050 |
| 49 | Hemiparesis (HP:0001269) | 2.45257781 |
| 50 | Abnormality of the lower motor neuron (HP:0002366) | 2.43608655 |
| 51 | Stereotypic behavior (HP:0000733) | 2.40858350 |
| 52 | Neurofibrillary tangles (HP:0002185) | 2.40832598 |
| 53 | Excessive salivation (HP:0003781) | 2.38853037 |
| 54 | Drooling (HP:0002307) | 2.38853037 |
| 55 | Megalencephaly (HP:0001355) | 2.36533382 |
| 56 | Occipital encephalocele (HP:0002085) | 2.36524802 |
| 57 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.36418848 |
| 58 | Truncus arteriosus (HP:0001660) | 2.36073655 |
| 59 | Diplopia (HP:0000651) | 2.34003969 |
| 60 | Abnormality of binocular vision (HP:0011514) | 2.34003969 |
| 61 | EEG with generalized epileptiform discharges (HP:0011198) | 2.31831968 |
| 62 | Deep palmar crease (HP:0006191) | 2.30752408 |
| 63 | Nasal polyposis (HP:0100582) | 2.30643223 |
| 64 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.29621691 |
| 65 | Abnormal connection of the cardiac segments (HP:0011545) | 2.25968248 |
| 66 | Abnormal ventriculo-arterial connection (HP:0011563) | 2.25968248 |
| 67 | Transposition of the great arteries (HP:0001669) | 2.25968248 |
| 68 | Hand muscle atrophy (HP:0009130) | 2.25096382 |
| 69 | Anosmia (HP:0000458) | 2.24945244 |
| 70 | Double outlet right ventricle (HP:0001719) | 2.23676514 |
| 71 | Congenital malformation of the right heart (HP:0011723) | 2.23676514 |
| 72 | Abnormal ciliary motility (HP:0012262) | 2.22574434 |
| 73 | Sleep apnea (HP:0010535) | 2.20181816 |
| 74 | Progressive inability to walk (HP:0002505) | 2.19346360 |
| 75 | Reticulocytopenia (HP:0001896) | 2.19320094 |
| 76 | Delusions (HP:0000746) | 2.18721894 |
| 77 | Polyphagia (HP:0002591) | 2.18593578 |
| 78 | Rib fusion (HP:0000902) | 2.17638975 |
| 79 | Mutism (HP:0002300) | 2.16710283 |
| 80 | Absent speech (HP:0001344) | 2.16665264 |
| 81 | Genital tract atresia (HP:0001827) | 2.16465262 |
| 82 | Vaginal atresia (HP:0000148) | 2.14559440 |
| 83 | Buphthalmos (HP:0000557) | 2.13651405 |
| 84 | Specific learning disability (HP:0001328) | 2.13486380 |
| 85 | Papilledema (HP:0001085) | 2.13171810 |
| 86 | Abnormal respiratory motile cilium physiology (HP:0012261) | 2.12451437 |
| 87 | Spastic gait (HP:0002064) | 2.12331975 |
| 88 | Postural instability (HP:0002172) | 2.11932434 |
| 89 | Scanning speech (HP:0002168) | 2.11885027 |
| 90 | Fetal akinesia sequence (HP:0001989) | 2.09896439 |
| 91 | Hypsarrhythmia (HP:0002521) | 2.08459703 |
| 92 | Annular pancreas (HP:0001734) | 2.07596225 |
| 93 | Renal duplication (HP:0000075) | 2.05340299 |
| 94 | Syncope (HP:0001279) | 2.04622228 |
| 95 | Genetic anticipation (HP:0003743) | 2.04394266 |
| 96 | Shallow orbits (HP:0000586) | 2.04066282 |
| 97 | Overriding aorta (HP:0002623) | 2.03677267 |
| 98 | Impaired smooth pursuit (HP:0007772) | 2.02855511 |
| 99 | Abnormality of macular pigmentation (HP:0008002) | 2.01923750 |
| 100 | Ventricular fibrillation (HP:0001663) | 2.01877205 |
| 101 | Distal upper limb amyotrophy (HP:0007149) | 2.01606668 |
| 102 | Upper limb amyotrophy (HP:0009129) | 2.01606668 |
| 103 | Hepatoblastoma (HP:0002884) | 2.01463807 |
| 104 | Coronal craniosynostosis (HP:0004440) | 2.01268905 |
| 105 | Bronchiectasis (HP:0002110) | 2.00326568 |
| 106 | Bradykinesia (HP:0002067) | 1.99725238 |
| 107 | Elfin facies (HP:0004428) | 1.98753586 |
| 108 | Urinary urgency (HP:0000012) | 1.98613519 |
| 109 | Central scotoma (HP:0000603) | 1.97119097 |
| 110 | Inability to walk (HP:0002540) | 1.96841089 |
| 111 | Abnormality of dentin (HP:0010299) | 1.96649059 |
| 112 | Absent/shortened dynein arms (HP:0200106) | 1.96602019 |
| 113 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 1.96602019 |
| 114 | Abnormal EKG (HP:0003115) | 1.95641214 |
| 115 | Stridor (HP:0010307) | 1.95060849 |
| 116 | Abnormality of midbrain morphology (HP:0002418) | 1.91953732 |
| 117 | Molar tooth sign on MRI (HP:0002419) | 1.91953732 |
| 118 | Termporal pattern (HP:0011008) | 1.89975747 |
| 119 | Insidious onset (HP:0003587) | 1.89975747 |
| 120 | Congenital glaucoma (HP:0001087) | 1.88976601 |
| 121 | Abnormality of cells of the erythroid lineage (HP:0012130) | 1.88911912 |
| 122 | Infertility (HP:0000789) | 1.88105315 |
| 123 | Pointed chin (HP:0000307) | 1.87913122 |
| 124 | Partial duplication of thumb phalanx (HP:0009944) | 1.86187148 |
| 125 | Anophthalmia (HP:0000528) | 1.85686577 |
| 126 | Incomplete penetrance (HP:0003829) | 1.85171077 |
| 127 | Poor coordination (HP:0002370) | 1.84112095 |
| 128 | Obstructive sleep apnea (HP:0002870) | 1.83009739 |
| 129 | Partial duplication of the phalanx of hand (HP:0009999) | 1.82653434 |
| 130 | Generalized myoclonic seizures (HP:0002123) | 1.82559329 |
| 131 | Lower limb muscle weakness (HP:0007340) | 1.82363032 |
| 132 | Ulnar bowing (HP:0003031) | 1.80918468 |
| 133 | Hemiplegia (HP:0002301) | 1.80843550 |
| 134 | Status epilepticus (HP:0002133) | 1.80643924 |
| 135 | Prolonged QT interval (HP:0001657) | 1.80560247 |
| 136 | Impaired vibratory sensation (HP:0002495) | 1.80385659 |
| 137 | Thickened helices (HP:0000391) | 1.79587412 |
| 138 | Abnormal respiratory motile cilium morphology (HP:0005938) | 1.78998726 |
| 139 | Abnormal respiratory epithelium morphology (HP:0012253) | 1.78998726 |
| 140 | Abnormality of salivation (HP:0100755) | 1.78209070 |
| 141 | Agitation (HP:0000713) | 1.77293932 |
| 142 | Sclerocornea (HP:0000647) | 1.76708942 |
| 143 | Hypoventilation (HP:0002791) | 1.75680865 |
| 144 | Insomnia (HP:0100785) | 1.75547369 |
| 145 | Type II lissencephaly (HP:0007260) | 1.73741544 |
| 146 | Aplasia involving bones of the extremities (HP:0009825) | 1.73412524 |
| 147 | Aplasia involving bones of the upper limbs (HP:0009823) | 1.73412524 |
| 148 | Aplasia of the phalanges of the hand (HP:0009802) | 1.73412524 |
| 149 | Absent epiphyses (HP:0010577) | 1.72329995 |
| 150 | Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003) | 1.72329995 |
| 151 | Male infertility (HP:0003251) | 1.71594416 |
| 152 | Protrusio acetabuli (HP:0003179) | 1.71264960 |
| 153 | Abnormality of the nasal mucosa (HP:0000433) | 1.71097420 |
| 154 | Renal dysplasia (HP:0000110) | 1.70943292 |
| 155 | Long palpebral fissure (HP:0000637) | 1.69782269 |
| 156 | Abnormality of the diencephalon (HP:0010662) | 1.64964579 |
| 157 | Renovascular hypertension (HP:0100817) | 1.64621578 |
| 158 | Pancreatic fibrosis (HP:0100732) | 1.63701298 |
| 159 | Anencephaly (HP:0002323) | 1.62431205 |
| 160 | Down-sloping shoulders (HP:0200021) | 1.62153768 |
| 161 | Abdominal situs inversus (HP:0003363) | 1.60361616 |
| 162 | Abnormality of abdominal situs (HP:0011620) | 1.60361616 |
| 163 | Broad metatarsal (HP:0001783) | 1.58644109 |
| 164 | Cutaneous syndactyly (HP:0012725) | 1.58586761 |
| 165 | Optic nerve coloboma (HP:0000588) | 1.58124018 |
| 166 | Meningocele (HP:0002435) | 1.57987846 |
| 167 | Arnold-Chiari malformation (HP:0002308) | 1.56740263 |
| 168 | Cystic liver disease (HP:0006706) | 1.54586604 |
| 169 | Anterior segment dysgenesis (HP:0007700) | 1.53691703 |
| 170 | Bladder diverticulum (HP:0000015) | 1.52843479 |
| 171 | Broad finger (HP:0001500) | 1.52583142 |
| 172 | Facial cleft (HP:0002006) | 1.51177510 |
| 173 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 1.50564822 |
| 174 | Broad phalanges of the hand (HP:0009768) | 1.49491282 |
| 175 | Aplasia/Hypoplasia of the brainstem (HP:0007362) | 1.49490118 |
| 176 | Hypoplasia of the brainstem (HP:0002365) | 1.49490118 |
| 177 | Hypercalcemia (HP:0003072) | 1.49252515 |
| 178 | Short nail (HP:0001799) | 1.49134426 |
| 179 | Oligodactyly (HP:0012165) | 1.47943279 |
| 180 | Maternal diabetes (HP:0009800) | 1.46896621 |
| 181 | Aplasia/Hypoplasia of the spleen (HP:0010451) | 1.44348435 |
| 182 | Self-mutilation (HP:0000742) | 1.44330535 |
| 183 | Septo-optic dysplasia (HP:0100842) | 1.43926577 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EPHA4 | 5.36363842 |
| 2 | NTRK3 | 4.44859985 |
| 3 | MAP3K9 | 3.54565808 |
| 4 | TRIB3 | 3.39329600 |
| 5 | MAPK15 | 3.09382421 |
| 6 | MAP3K4 | 2.61044248 |
| 7 | DAPK2 | 2.47673933 |
| 8 | MAP2K7 | 2.42063593 |
| 9 | ICK | 2.39973829 |
| 10 | MARK1 | 2.37058808 |
| 11 | CASK | 2.37042347 |
| 12 | MINK1 | 2.34711354 |
| 13 | SMG1 | 2.28279173 |
| 14 | KSR2 | 2.26619924 |
| 15 | ARAF | 2.26406201 |
| 16 | EEF2K | 2.25349839 |
| 17 | PRKD3 | 2.24955712 |
| 18 | RIPK4 | 2.15532252 |
| 19 | BMPR2 | 2.10994981 |
| 20 | EPHB2 | 2.00260653 |
| 21 | DYRK2 | 1.99649628 |
| 22 | MAP3K12 | 1.98954723 |
| 23 | NTRK2 | 1.95624422 |
| 24 | PAK6 | 1.81401690 |
| 25 | MAP3K13 | 1.74231852 |
| 26 | PLK2 | 1.73752206 |
| 27 | TNIK | 1.73501092 |
| 28 | SIK1 | 1.62317172 |
| 29 | KSR1 | 1.61147324 |
| 30 | DAPK1 | 1.58199546 |
| 31 | NTRK1 | 1.57793771 |
| 32 | GRK5 | 1.55353938 |
| 33 | MAP2K4 | 1.54815135 |
| 34 | EPHA2 | 1.53145817 |
| 35 | CAMKK1 | 1.51517744 |
| 36 | CDK5 | 1.47385587 |
| 37 | SIK2 | 1.44879044 |
| 38 | PRPF4B | 1.33499112 |
| 39 | MAPK13 | 1.32580009 |
| 40 | FES | 1.32577581 |
| 41 | PRKCG | 1.22943522 |
| 42 | BRSK1 | 1.19879460 |
| 43 | AURKA | 1.16622423 |
| 44 | MOS | 1.15148191 |
| 45 | CDC7 | 1.15123009 |
| 46 | DYRK1B | 1.13285242 |
| 47 | STK38 | 1.12997875 |
| 48 | CAMK2A | 1.11959138 |
| 49 | CAMK2B | 1.10449883 |
| 50 | RPS6KA2 | 1.10345457 |
| 51 | LRRK2 | 1.09476291 |
| 52 | CDK19 | 1.08621161 |
| 53 | TAOK1 | 1.06720569 |
| 54 | PHKG1 | 1.04643362 |
| 55 | PHKG2 | 1.04643362 |
| 56 | FGFR2 | 1.02253845 |
| 57 | LIMK1 | 1.01454014 |
| 58 | SGK494 | 0.99056969 |
| 59 | SGK223 | 0.99056969 |
| 60 | PTK2B | 0.98908020 |
| 61 | PNCK | 0.98592729 |
| 62 | MAP3K2 | 0.98243042 |
| 63 | MAP3K10 | 0.97576994 |
| 64 | RAF1 | 0.95893431 |
| 65 | NME2 | 0.94864458 |
| 66 | MAP3K11 | 0.94552102 |
| 67 | PTK2 | 0.92421406 |
| 68 | BRAF | 0.90654029 |
| 69 | TYRO3 | 0.89223868 |
| 70 | VRK2 | 0.88245487 |
| 71 | UHMK1 | 0.87059631 |
| 72 | DYRK1A | 0.86502850 |
| 73 | RIPK1 | 0.84401876 |
| 74 | PAK3 | 0.83342462 |
| 75 | CDK18 | 0.81609654 |
| 76 | STK16 | 0.81130707 |
| 77 | CAMKK2 | 0.79517028 |
| 78 | TNK2 | 0.78722430 |
| 79 | CDK15 | 0.78097715 |
| 80 | MARK2 | 0.77904840 |
| 81 | SGK2 | 0.77212688 |
| 82 | PINK1 | 0.76573858 |
| 83 | CDK14 | 0.75964229 |
| 84 | CAMK2D | 0.74302341 |
| 85 | IRAK2 | 0.73838835 |
| 86 | MTOR | 0.73182447 |
| 87 | CHEK2 | 0.73132261 |
| 88 | FGR | 0.73118770 |
| 89 | CAMK1 | 0.72371797 |
| 90 | PDGFRA | 0.71145961 |
| 91 | ADRBK2 | 0.69637055 |
| 92 | PIM2 | 0.69394095 |
| 93 | NEK2 | 0.68996444 |
| 94 | AKT2 | 0.68330230 |
| 95 | LATS2 | 0.68171421 |
| 96 | CDK11A | 0.66663454 |
| 97 | CAMK1D | 0.66327958 |
| 98 | TESK1 | 0.66104323 |
| 99 | STK11 | 0.65709597 |
| 100 | MAP3K6 | 0.65473625 |
| 101 | PRKCH | 0.64132669 |
| 102 | CAMK1G | 0.63715985 |
| 103 | DDR2 | 0.63544788 |
| 104 | MAP3K1 | 0.62789017 |
| 105 | PKN2 | 0.61902059 |
| 106 | WNK4 | 0.61797000 |
| 107 | MAP2K2 | 0.61723459 |
| 108 | CSNK1G2 | 0.61180293 |
| 109 | SGK1 | 0.60489800 |
| 110 | RPS6KL1 | 0.59896216 |
| 111 | RPS6KC1 | 0.59896216 |
| 112 | OXSR1 | 0.59678472 |
| 113 | SIK3 | 0.59314085 |
| 114 | CAMK2G | 0.59129086 |
| 115 | ILK | 0.58900862 |
| 116 | FER | 0.58281699 |
| 117 | PRKCI | 0.57959522 |
| 118 | RET | 0.56908862 |
| 119 | NME1 | 0.56002159 |
| 120 | LMTK2 | 0.54231514 |
| 121 | PRKCE | 0.54155773 |
| 122 | SGK3 | 0.52670446 |
| 123 | DYRK3 | 0.51658269 |
| 124 | CSNK1E | 0.50997528 |
| 125 | MAP2K1 | 0.50548134 |
| 126 | RPS6KA6 | 0.50313987 |
| 127 | RPS6KB2 | 0.50083131 |
| 128 | CSNK1G3 | 0.47972301 |
| 129 | FGFR4 | 0.47480908 |
| 130 | PRKD2 | 0.47429498 |
| 131 | CAMK4 | 0.46706031 |
| 132 | PDPK1 | 0.45741926 |
| 133 | PAK1 | 0.45535874 |
| 134 | ERBB3 | 0.44716136 |
| 135 | CDK8 | 0.43991010 |
| 136 | MAP3K8 | 0.43610803 |
| 137 | PRKCZ | 0.42833468 |
| 138 | PDK1 | 0.41965754 |
| 139 | BCKDK | 0.40563810 |
| 140 | HIPK2 | 0.40497012 |
| 141 | DAPK3 | 0.40110340 |
| 142 | ABL2 | 0.40045238 |
| 143 | WNK3 | 0.39448028 |
| 144 | FYN | 0.37267546 |
| 145 | MAPK10 | 0.37129759 |
| 146 | ROCK2 | 0.36819752 |
| 147 | AKT3 | 0.36292271 |
| 148 | RPS6KA3 | 0.35231827 |
| 149 | MUSK | 0.33624608 |
| 150 | MAP3K7 | 0.33558878 |
| 151 | PRKACA | 0.31919809 |
| 152 | PRKCA | 0.31764664 |
| 153 | CDC42BPA | 0.31476948 |
| 154 | ADRBK1 | 0.31240983 |
| 155 | PRKCB | 0.26908229 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Olfactory transduction_Homo sapiens_hsa04740 | 4.11179992 |
| 2 | Nicotine addiction_Homo sapiens_hsa05033 | 3.60253983 |
| 3 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 3.15081012 |
| 4 | Ribosome_Homo sapiens_hsa03010 | 3.05070238 |
| 5 | Circadian entrainment_Homo sapiens_hsa04713 | 2.76598430 |
| 6 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.73937817 |
| 7 | GABAergic synapse_Homo sapiens_hsa04727 | 2.73690605 |
| 8 | Morphine addiction_Homo sapiens_hsa05032 | 2.71102745 |
| 9 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.61729153 |
| 10 | Long-term potentiation_Homo sapiens_hsa04720 | 2.59540629 |
| 11 | Basal cell carcinoma_Homo sapiens_hsa05217 | 2.45207937 |
| 12 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.44191695 |
| 13 | Sulfur relay system_Homo sapiens_hsa04122 | 2.36882976 |
| 14 | Dopaminergic synapse_Homo sapiens_hsa04728 | 2.21288727 |
| 15 | Salivary secretion_Homo sapiens_hsa04970 | 2.19281515 |
| 16 | Insulin secretion_Homo sapiens_hsa04911 | 2.12931225 |
| 17 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 2.04178012 |
| 18 | Taste transduction_Homo sapiens_hsa04742 | 1.98013207 |
| 19 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.92911151 |
| 20 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.92668458 |
| 21 | Notch signaling pathway_Homo sapiens_hsa04330 | 1.90210777 |
| 22 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.87982215 |
| 23 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.82203901 |
| 24 | Renin secretion_Homo sapiens_hsa04924 | 1.79505689 |
| 25 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.75838617 |
| 26 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.73696497 |
| 27 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.66291267 |
| 28 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.64811870 |
| 29 | Hippo signaling pathway_Homo sapiens_hsa04390 | 1.63309651 |
| 30 | Cocaine addiction_Homo sapiens_hsa05030 | 1.58602401 |
| 31 | Long-term depression_Homo sapiens_hsa04730 | 1.57570069 |
| 32 | Phototransduction_Homo sapiens_hsa04744 | 1.55535469 |
| 33 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.53956660 |
| 34 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.53900792 |
| 35 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.52803567 |
| 36 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.36325273 |
| 37 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.32401319 |
| 38 | Gap junction_Homo sapiens_hsa04540 | 1.31470251 |
| 39 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.25504481 |
| 40 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.18159954 |
| 41 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.16245962 |
| 42 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.12598781 |
| 43 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.11976887 |
| 44 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.11660728 |
| 45 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.09969945 |
| 46 | Melanogenesis_Homo sapiens_hsa04916 | 1.07435074 |
| 47 | Base excision repair_Homo sapiens_hsa03410 | 1.06905669 |
| 48 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.03107070 |
| 49 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 1.01808710 |
| 50 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 1.01804111 |
| 51 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 1.01778628 |
| 52 | Axon guidance_Homo sapiens_hsa04360 | 1.01681330 |
| 53 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.01370926 |
| 54 | Glioma_Homo sapiens_hsa05214 | 0.96614792 |
| 55 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.94847532 |
| 56 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.93935466 |
| 57 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.89415474 |
| 58 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.87239118 |
| 59 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.84837565 |
| 60 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.82568242 |
| 61 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.81579926 |
| 62 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.81296284 |
| 63 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.79610741 |
| 64 | Bladder cancer_Homo sapiens_hsa05219 | 0.78108219 |
| 65 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.76301439 |
| 66 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.75880029 |
| 67 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.75801072 |
| 68 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.75301386 |
| 69 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.73821898 |
| 70 | Alzheimers disease_Homo sapiens_hsa05010 | 0.72595738 |
| 71 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.72264544 |
| 72 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.70908106 |
| 73 | Tight junction_Homo sapiens_hsa04530 | 0.70877718 |
| 74 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.70854838 |
| 75 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.70450528 |
| 76 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.68490497 |
| 77 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.67984995 |
| 78 | DNA replication_Homo sapiens_hsa03030 | 0.66712680 |
| 79 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.66512978 |
| 80 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.63811604 |
| 81 | RNA polymerase_Homo sapiens_hsa03020 | 0.63354053 |
| 82 | Circadian rhythm_Homo sapiens_hsa04710 | 0.63188575 |
| 83 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.62418692 |
| 84 | Colorectal cancer_Homo sapiens_hsa05210 | 0.61721260 |
| 85 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.61523283 |
| 86 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.61218384 |
| 87 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.60663969 |
| 88 | Alcoholism_Homo sapiens_hsa05034 | 0.59403728 |
| 89 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.58271418 |
| 90 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.57893854 |
| 91 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.57465899 |
| 92 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.57052216 |
| 93 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.56992021 |
| 94 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.56478701 |
| 95 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.55935716 |
| 96 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.55488520 |
| 97 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.53513679 |
| 98 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.53275695 |
| 99 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.52835185 |
| 100 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.52437903 |
| 101 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.50789389 |
| 102 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.50658607 |
| 103 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.50619086 |
| 104 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.50451401 |
| 105 | Parkinsons disease_Homo sapiens_hsa05012 | 0.48467062 |
| 106 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.48284241 |
| 107 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.47283534 |
| 108 | Melanoma_Homo sapiens_hsa05218 | 0.45731579 |
| 109 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.43420941 |
| 110 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.42733570 |
| 111 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.42613543 |
| 112 | Prion diseases_Homo sapiens_hsa05020 | 0.42532047 |
| 113 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.41276117 |
| 114 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.41237541 |
| 115 | Bile secretion_Homo sapiens_hsa04976 | 0.40932147 |
| 116 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.40867388 |
| 117 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.40518963 |
| 118 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.40230792 |
| 119 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.39724731 |
| 120 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.39437556 |
| 121 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.39420295 |
| 122 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.38562632 |
| 123 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.38480953 |
| 124 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.38430341 |
| 125 | Endocytosis_Homo sapiens_hsa04144 | 0.35892532 |
| 126 | Huntingtons disease_Homo sapiens_hsa05016 | 0.35346615 |
| 127 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.34541270 |
| 128 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.34242618 |
| 129 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.34220816 |
| 130 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.33483186 |
| 131 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.31952225 |
| 132 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.31714954 |
| 133 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.30603851 |
| 134 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.28975202 |
| 135 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.28307169 |
| 136 | Endometrial cancer_Homo sapiens_hsa05213 | 0.26983743 |
| 137 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.26962732 |
| 138 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.26666341 |

