ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	4.30347890
2	nucleobase catabolic process (GO:0046113)	4.19725230
3	pyrimidine nucleobase catabolic process (GO:0006208)	4.14806363
4	neuron cell-cell adhesion (GO:0007158)	3.85696719
5	glycerophospholipid catabolic process (GO:0046475)	3.62546419
6	cellular ketone body metabolic process (GO:0046950)	3.60173371
7	postsynaptic membrane organization (GO:0001941)	3.56658351
8	proline transport (GO:0015824)	3.50296162
9	regulation of neurotransmitter uptake (GO:0051580)	3.37351521
10	behavioral response to ethanol (GO:0048149)	3.36209178
11	neuronal action potential propagation (GO:0019227)	3.33693192
12	dendritic spine morphogenesis (GO:0060997)	3.33688493
13	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.27695686
14	nonmotile primary cilium assembly (GO:0035058)	3.25773698
15	regulation of action potential (GO:0098900)	3.23138416
16	platelet dense granule organization (GO:0060155)	3.21366941
17	presynaptic membrane assembly (GO:0097105)	3.20302145
18	ketone body metabolic process (GO:1902224)	3.20013192
19	positive regulation of action potential (GO:0045760)	3.19734403
20	piRNA metabolic process (GO:0034587)	3.19317820
21	inositol phosphate catabolic process (GO:0071545)	3.17847542
22	response to pheromone (GO:0019236)	3.16997860
23	presynaptic membrane organization (GO:0097090)	3.10943887
24	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	3.03761977
25	gamma-aminobutyric acid transport (GO:0015812)	3.02353149
26	positive regulation of mitochondrial fission (GO:0090141)	2.97965842
27	startle response (GO:0001964)	2.93881646
28	epithelial cilium movement (GO:0003351)	2.93687635
29	anterograde synaptic vesicle transport (GO:0048490)	2.92784034
30	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.92090295
31	protein K11-linked deubiquitination (GO:0035871)	2.89291237
32	protein localization to cilium (GO:0061512)	2.87185369
33	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.87173578
34	preassembly of GPI anchor in ER membrane (GO:0016254)	2.86521519
35	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.86254278
36	regulation of short-term neuronal synaptic plasticity (GO:0048172)	2.85971161
37	neural tube formation (GO:0001841)	2.85358832
38	water-soluble vitamin biosynthetic process (GO:0042364)	2.83334368
39	inositol phosphate dephosphorylation (GO:0046855)	2.77671101
40	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.77671101
41	auditory behavior (GO:0031223)	2.77183389
42	protein localization to synapse (GO:0035418)	2.75574559
43	synaptic vesicle maturation (GO:0016188)	2.74536305
44	synapse assembly (GO:0007416)	2.73699384
45	protein-cofactor linkage (GO:0018065)	2.73566552
46	axoneme assembly (GO:0035082)	2.70918939
47	regulation of glucokinase activity (GO:0033131)	2.68646171
48	regulation of hexokinase activity (GO:1903299)	2.68646171
49	protein complex biogenesis (GO:0070271)	2.68642208
50	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	2.67426530
51	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	2.67426530
52	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.65341667
53	ionotropic glutamate receptor signaling pathway (GO:0035235)	2.63694468
54	retinal cone cell development (GO:0046549)	2.63039690
55	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.62717270
56	membrane depolarization during action potential (GO:0086010)	2.62714202
57	regulation of telomere maintenance (GO:0032204)	2.60354085
58	synaptic transmission, glutamatergic (GO:0035249)	2.59954732
59	establishment of protein localization to Golgi (GO:0072600)	2.59898267
60	negative regulation of heart rate (GO:0010459)	2.59206322
61	DNA methylation involved in gamete generation (GO:0043046)	2.57600791
62	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.56789311
63	C-terminal protein amino acid modification (GO:0018410)	2.56764772
64	C-terminal protein lipidation (GO:0006501)	2.56022635
65	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.55531496
66	NADH dehydrogenase complex assembly (GO:0010257)	2.55531496
67	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.55531496
68	detection of light stimulus involved in sensory perception (GO:0050962)	2.55443106
69	detection of light stimulus involved in visual perception (GO:0050908)	2.55443106
70	respiratory chain complex IV assembly (GO:0008535)	2.54851400
71	synaptic transmission, cholinergic (GO:0007271)	2.53448688
72	reflex (GO:0060004)	2.52134552
73	neuronal action potential (GO:0019228)	2.51701057
74	glycosphingolipid biosynthetic process (GO:0006688)	2.51114047
75	glutamate receptor signaling pathway (GO:0007215)	2.50862299
76	kidney morphogenesis (GO:0060993)	2.50075227
77	protein polyglutamylation (GO:0018095)	2.49763243
78	cilium organization (GO:0044782)	2.48036355
79	cilium assembly (GO:0042384)	2.46538525
80	serotonin metabolic process (GO:0042428)	2.46135491
81	axonal fasciculation (GO:0007413)	2.45276648
82	dopamine transport (GO:0015872)	2.44465250
83	endocrine pancreas development (GO:0031018)	2.44245852
84	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.43735724
85	indolalkylamine metabolic process (GO:0006586)	2.43162816
86	polyol catabolic process (GO:0046174)	2.42966825
87	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	2.42737651
88	L-fucose catabolic process (GO:0042355)	2.42237294
89	fucose catabolic process (GO:0019317)	2.42237294
90	L-fucose metabolic process (GO:0042354)	2.42237294
91	cilium morphogenesis (GO:0060271)	2.41999890
92	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.41083430
93	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.41083430
94	regulation of translation, ncRNA-mediated (GO:0045974)	2.41083430
95	protein targeting to Golgi (GO:0000042)	2.39383149
96	anterograde axon cargo transport (GO:0008089)	2.38945255
97	mitochondrial respiratory chain complex assembly (GO:0033108)	2.38452744
98	primary amino compound metabolic process (GO:1901160)	2.38155031
99	negative regulation of telomere maintenance (GO:0032205)	2.37526877
100	peptidyl-histidine modification (GO:0018202)	2.36868697

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.64133746
2	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.35394913
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.01519467
4	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.72551285
5	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.71196056
6	IGF1R_20145208_ChIP-Seq_DFB_Human	2.69913579
7	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.56034754
8	EZH2_22144423_ChIP-Seq_EOC_Human	2.47440638
9	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.42494698
10	FUS_26573619_Chip-Seq_HEK293_Human	2.40576233
11	VDR_22108803_ChIP-Seq_LS180_Human	2.36230362
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.31499549
13	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.06189535
14	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.99790554
15	REST_21632747_ChIP-Seq_MESCs_Mouse	1.99568010
16	TAF15_26573619_Chip-Seq_HEK293_Human	1.94590501
17	P300_19829295_ChIP-Seq_ESCs_Human	1.89915217
18	EWS_26573619_Chip-Seq_HEK293_Human	1.76838231
19	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.73192287
20	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.68005387
21	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.66918584
22	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.66871673
23	ER_23166858_ChIP-Seq_MCF-7_Human	1.66446312
24	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.64000402
25	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.61956655
26	SMAD4_21799915_ChIP-Seq_A2780_Human	1.61881779
27	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.59767731
28	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.58209391
29	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.58123364
30	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.55487687
31	STAT3_23295773_ChIP-Seq_U87_Human	1.55440192
32	AR_25329375_ChIP-Seq_VCAP_Human	1.55426923
33	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.55422541
34	BCAT_22108803_ChIP-Seq_LS180_Human	1.55066783
35	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.52328859
36	TP53_22573176_ChIP-Seq_HFKS_Human	1.49718217
37	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.47440462
38	CBP_20019798_ChIP-Seq_JUKART_Human	1.45925067
39	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.45925067
40	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.45574818
41	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.44430077
42	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.43859023
43	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.43564696
44	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.42627267
45	TCF4_23295773_ChIP-Seq_U87_Human	1.39122826
46	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.38700584
47	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.33879498
48	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.33813478
49	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.33151198
50	RNF2_27304074_Chip-Seq_NSC_Mouse	1.32933346
51	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.32811556
52	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.31143778
53	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.31120580
54	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.29814208
55	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.28300534
56	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.28183217
57	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.27031806
58	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.27031806
59	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.26216071
60	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.24460389
61	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.22957572
62	TCF4_22108803_ChIP-Seq_LS180_Human	1.21645789
63	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.21401740
64	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.17619488
65	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.16823609
66	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.16162733
67	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.15188622
68	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.14930647
69	RUNX2_22187159_ChIP-Seq_PCA_Human	1.14783252
70	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.14207148
71	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.13835341
72	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.13817397
73	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.13459043
74	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.13404127
75	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.12983765
76	NANOG_19829295_ChIP-Seq_ESCs_Human	1.12606869
77	SOX2_19829295_ChIP-Seq_ESCs_Human	1.12606869
78	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.11851078
79	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.11490665
80	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.10830872
81	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.10815577
82	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.08567951
83	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.08567951
84	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.08365776
85	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.07002290
86	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.06664426
87	NCOR_22424771_ChIP-Seq_293T_Human	1.06212270
88	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.05580302
89	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.04765480
90	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.04165604
91	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.03939103
92	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.02924348
93	AR_21572438_ChIP-Seq_LNCaP_Human	1.01859923
94	P53_22387025_ChIP-Seq_ESCs_Mouse	1.01575911
95	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.01365611
96	MYC_18940864_ChIP-ChIP_HL60_Human	1.00129475
97	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.99781805
98	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.99588885
99	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	0.99351006
100	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.98583020

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.37752280
2	MP0003787_abnormal_imprinting	3.32948471
3	MP0001968_abnormal_touch/_nociception	2.75597197
4	MP0002837_dystrophic_cardiac_calcinosis	2.52929893
5	MP0003122_maternal_imprinting	2.45124191
6	MP0002736_abnormal_nociception_after	2.43226629
7	MP0005645_abnormal_hypothalamus_physiol	2.42647102
8	MP0009046_muscle_twitch	2.42288596
9	MP0004270_analgesia	2.31134032
10	MP0001984_abnormal_olfaction	2.18132938
11	MP0009745_abnormal_behavioral_response	2.16238465
12	MP0004859_abnormal_synaptic_plasticity	2.13625717
13	MP0002638_abnormal_pupillary_reflex	2.13376780
14	MP0006072_abnormal_retinal_apoptosis	2.09855299
15	MP0003121_genomic_imprinting	2.07540160
16	MP0002909_abnormal_adrenal_gland	2.07199264
17	MP0002272_abnormal_nervous_system	2.04424992
18	MP0003195_calcinosis	2.03186413
19	MP0005551_abnormal_eye_electrophysiolog	2.02532273
20	MP0003635_abnormal_synaptic_transmissio	1.89000283
21	MP0003880_abnormal_central_pattern	1.84568401
22	MP0001501_abnormal_sleep_pattern	1.81735939
23	MP0001986_abnormal_taste_sensitivity	1.81402647
24	MP0005253_abnormal_eye_physiology	1.80794052
25	MP0006276_abnormal_autonomic_nervous	1.80084327
26	MP0005379_endocrine/exocrine_gland_phen	1.79625030
27	MP0002102_abnormal_ear_morphology	1.79564084
28	MP0002572_abnormal_emotion/affect_behav	1.77476168
29	MP0004885_abnormal_endolymph	1.77469926
30	MP0010386_abnormal_urinary_bladder	1.76109789
31	MP0001529_abnormal_vocalization	1.72896679
32	MP0002734_abnormal_mechanical_nocicepti	1.71973213
33	MP0002557_abnormal_social/conspecific_i	1.71455156
34	MP0005646_abnormal_pituitary_gland	1.65647217
35	MP0002063_abnormal_learning/memory/cond	1.65397758
36	MP0004142_abnormal_muscle_tone	1.62533859
37	MP0002876_abnormal_thyroid_physiology	1.61380069
38	MP0002064_seizures	1.61348635
39	MP0001486_abnormal_startle_reflex	1.59528732
40	MP0002735_abnormal_chemical_nociception	1.56364590
41	MP0001905_abnormal_dopamine_level	1.52163444
42	MP0001502_abnormal_circadian_rhythm	1.50852290
43	MP0005423_abnormal_somatic_nervous	1.50562249
44	MP0000631_abnormal_neuroendocrine_gland	1.50084177
45	MP0002733_abnormal_thermal_nociception	1.46754867
46	MP0001970_abnormal_pain_threshold	1.45781560
47	MP0000013_abnormal_adipose_tissue	1.38927810
48	MP0000778_abnormal_nervous_system	1.36527443
49	MP0002163_abnormal_gland_morphology	1.34659083
50	MP0005084_abnormal_gallbladder_morpholo	1.34308441
51	MP0004133_heterotaxia	1.34273107
52	MP0002928_abnormal_bile_duct	1.33233790
53	MP0002067_abnormal_sensory_capabilities	1.31976357
54	MP0004043_abnormal_pH_regulation	1.29078594
55	MP0003011_delayed_dark_adaptation	1.26996630
56	MP0004924_abnormal_behavior	1.26465533
57	MP0005386_behavior/neurological_phenoty	1.26465533
58	MP0009780_abnormal_chondrocyte_physiolo	1.26244033
59	MP0001188_hyperpigmentation	1.25023694
60	MP0002693_abnormal_pancreas_physiology	1.21917766
61	MP0002184_abnormal_innervation	1.21218323
62	MP0002229_neurodegeneration	1.16789453
63	MP0001440_abnormal_grooming_behavior	1.15875130
64	MP0001944_abnormal_pancreas_morphology	1.15284023
65	MP0000372_irregular_coat_pigmentation	1.07589638
66	MP0004742_abnormal_vestibular_system	1.06968558
67	MP0000427_abnormal_hair_cycle	1.05215151
68	MP0008872_abnormal_physiological_respon	1.05078477
69	MP0003646_muscle_fatigue	1.03933933
70	MP0002882_abnormal_neuron_morphology	0.99710945
71	MP0004811_abnormal_neuron_physiology	0.99388561
72	MP0002653_abnormal_ependyma_morphology	0.95549766
73	MP0004215_abnormal_myocardial_fiber	0.92193625
74	MP0002751_abnormal_autonomic_nervous	0.92076214
75	MP0003123_paternal_imprinting	0.91148670
76	MP0000955_abnormal_spinal_cord	0.90163566
77	MP0002069_abnormal_eating/drinking_beha	0.89456126
78	MP0002752_abnormal_somatic_nervous	0.88576141
79	MP0002938_white_spotting	0.88099561
80	MP0001485_abnormal_pinna_reflex	0.87996361
81	MP0008875_abnormal_xenobiotic_pharmacok	0.87864458
82	MP0004085_abnormal_heartbeat	0.87769606
83	MP0001919_abnormal_reproductive_system	0.87007265
84	MP0001764_abnormal_homeostasis	0.86984460
85	MP0005389_reproductive_system_phenotype	0.85950985
86	MP0000569_abnormal_digit_pigmentation	0.84235997
87	MP0004145_abnormal_muscle_electrophysio	0.83944208
88	MP0000639_abnormal_adrenal_gland	0.83350856
89	MP0002066_abnormal_motor_capabilities/c	0.81111658
90	MP0002160_abnormal_reproductive_system	0.80784393
91	MP0005195_abnormal_posterior_eye	0.80608408
92	MP0003633_abnormal_nervous_system	0.80381667
93	MP0008995_early_reproductive_senescence	0.80238998
94	MP0003698_abnormal_male_reproductive	0.80016829
95	MP0008789_abnormal_olfactory_epithelium	0.79197398
96	MP0008058_abnormal_DNA_repair	0.78570675
97	MP0001756_abnormal_urination	0.77263580
98	MP0006292_abnormal_olfactory_placode	0.76807329
99	MP0005448_abnormal_energy_balance	0.75904788
100	MP0005394_taste/olfaction_phenotype	0.74965525

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Medial flaring of the eyebrow (HP:0010747)	3.79292904
2	Pancreatic cysts (HP:0001737)	3.68462261
3	Abnormality of midbrain morphology (HP:0002418)	3.61156604
4	Molar tooth sign on MRI (HP:0002419)	3.61156604
5	Hyperventilation (HP:0002883)	3.43812967
6	Pancreatic fibrosis (HP:0100732)	3.39061540
7	Nephronophthisis (HP:0000090)	3.37755080
8	Gait imbalance (HP:0002141)	3.32417295
9	Limb dystonia (HP:0002451)	3.31886552
10	True hermaphroditism (HP:0010459)	3.23061574
11	Congenital stationary night blindness (HP:0007642)	3.03988056
12	Agitation (HP:0000713)	3.02302679
13	Type II lissencephaly (HP:0007260)	3.01704060
14	Congenital primary aphakia (HP:0007707)	2.98789059
15	Abnormality of the renal cortex (HP:0011035)	2.98674116
16	Lissencephaly (HP:0001339)	2.88637530
17	Abnormality of the renal medulla (HP:0100957)	2.79798692
18	Nephrogenic diabetes insipidus (HP:0009806)	2.76709881
19	Hypothermia (HP:0002045)	2.75021636
20	Abnormal drinking behavior (HP:0030082)	2.65020363
21	Polydipsia (HP:0001959)	2.65020363
22	Acute necrotizing encephalopathy (HP:0006965)	2.64778953
23	Pendular nystagmus (HP:0012043)	2.64167447
24	Pachygyria (HP:0001302)	2.63397902
25	Progressive macrocephaly (HP:0004481)	2.59080256
26	Chronic hepatic failure (HP:0100626)	2.57207156
27	Hypsarrhythmia (HP:0002521)	2.57104774
28	Intestinal atresia (HP:0011100)	2.56848273
29	EEG with generalized epileptiform discharges (HP:0011198)	2.54897409
30	Abnormal rod and cone electroretinograms (HP:0008323)	2.53447661
31	Drooling (HP:0002307)	2.49762883
32	Epileptiform EEG discharges (HP:0011182)	2.49415641
33	Tubular atrophy (HP:0000092)	2.48841070
34	Retinal dysplasia (HP:0007973)	2.48102306
35	Attenuation of retinal blood vessels (HP:0007843)	2.46675262
36	Genital tract atresia (HP:0001827)	2.44586854
37	Hepatic necrosis (HP:0002605)	2.44114411
38	Renal cortical cysts (HP:0000803)	2.41174665
39	Large for gestational age (HP:0001520)	2.39968994
40	Febrile seizures (HP:0002373)	2.38833074
41	Polyphagia (HP:0002591)	2.36875103
42	Vaginal atresia (HP:0000148)	2.32641700
43	Hepatocellular necrosis (HP:0001404)	2.32244568
44	Mitochondrial inheritance (HP:0001427)	2.31355165
45	Excessive salivation (HP:0003781)	2.22907008
46	Abnormality of the labia minora (HP:0012880)	2.21839499
47	Broad-based gait (HP:0002136)	2.20532914
48	Ketoacidosis (HP:0001993)	2.20037144
49	Poor coordination (HP:0002370)	2.19994477
50	Acute encephalopathy (HP:0006846)	2.19932397
51	Cystic liver disease (HP:0006706)	2.18511825
52	Inability to walk (HP:0002540)	2.16688390
53	Abnormal mitochondria in muscle tissue (HP:0008316)	2.15207811
54	Epileptic encephalopathy (HP:0200134)	2.10769904
55	Bony spicule pigmentary retinopathy (HP:0007737)	2.09803005
56	Congenital sensorineural hearing impairment (HP:0008527)	2.08363182
57	Increased CSF lactate (HP:0002490)	2.06238000
58	Progressive cerebellar ataxia (HP:0002073)	2.03865307
59	Absent speech (HP:0001344)	2.03697374
60	Abnormal albumin level (HP:0012116)	2.02176694
61	Hypoalbuminemia (HP:0003073)	2.02176694
62	Sclerocornea (HP:0000647)	2.00722630
63	Dialeptic seizures (HP:0011146)	2.00163009
64	Hemiparesis (HP:0001269)	1.99401343
65	Polyuria (HP:0000103)	1.98932229
66	Bile duct proliferation (HP:0001408)	1.98695987
67	Abnormal biliary tract physiology (HP:0012439)	1.98695987
68	Hypoglycemic coma (HP:0001325)	1.97201283
69	Gaze-evoked nystagmus (HP:0000640)	1.97006968
70	Muscular hypotonia of the trunk (HP:0008936)	1.96984096
71	Occipital encephalocele (HP:0002085)	1.94500909
72	Cerebellar dysplasia (HP:0007033)	1.92971831
73	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.90542278
74	Ketosis (HP:0001946)	1.90472220
75	3-Methylglutaconic aciduria (HP:0003535)	1.89837236
76	Specific learning disability (HP:0001328)	1.89690429
77	Spastic tetraplegia (HP:0002510)	1.88061094
78	Adrenal hypoplasia (HP:0000835)	1.86634814
79	Lipid accumulation in hepatocytes (HP:0006561)	1.86335213
80	Postaxial hand polydactyly (HP:0001162)	1.86038475
81	Protruding tongue (HP:0010808)	1.85864442
82	Narrow forehead (HP:0000341)	1.85262681
83	Abolished electroretinogram (ERG) (HP:0000550)	1.85025209
84	Optic nerve hypoplasia (HP:0000609)	1.82885696
85	Glycosuria (HP:0003076)	1.76018038
86	Abnormality of urine glucose concentration (HP:0011016)	1.76018038
87	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.74915575
88	Aplasia/hypoplasia of the uterus (HP:0008684)	1.74773618
89	Esotropia (HP:0000565)	1.73819564
90	Absence seizures (HP:0002121)	1.73426252
91	Progressive inability to walk (HP:0002505)	1.73335744
92	Late onset (HP:0003584)	1.73211748
93	Rib fusion (HP:0000902)	1.72034840
94	Optic disc pallor (HP:0000543)	1.71816488
95	Focal motor seizures (HP:0011153)	1.69589333
96	Severe muscular hypotonia (HP:0006829)	1.67994251
97	Increased corneal curvature (HP:0100692)	1.67627904
98	Keratoconus (HP:0000563)	1.67627904
99	Left ventricular hypertrophy (HP:0001712)	1.66570020
100	Volvulus (HP:0002580)	1.66543639

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.14128137
2	MAP4K2	4.02695990
3	CASK	3.23687058
4	PINK1	3.06163175
5	MARK1	2.91694420
6	TNIK	2.58063543
7	MAP3K4	2.52032393
8	WNK3	2.41956560
9	GRK1	2.33315917
10	ADRBK2	2.24029729
11	MAPK13	2.04513885
12	PAK3	1.91985957
13	MKNK2	1.86756186
14	NUAK1	1.83020307
15	STK16	1.82602645
16	TAOK3	1.79134728
17	DYRK2	1.76227865
18	MAP2K7	1.71621326
19	DAPK2	1.69305477
20	NTRK3	1.61735462
21	WNK4	1.56226114
22	TRIM28	1.51926389
23	PNCK	1.49842365
24	BMPR1B	1.48059516
25	PHKG1	1.46544920
26	PHKG2	1.46544920
27	PRKCG	1.41170693
28	CSNK1G2	1.40820075
29	MAP2K6	1.40355947
30	BCR	1.38515169
31	CSNK1G3	1.38214195
32	CSNK1G1	1.31026981
33	MINK1	1.25784711
34	PRKCE	1.17535582
35	SIK2	1.06258765
36	INSRR	1.00173804
37	CSNK1A1L	0.99947959
38	FGFR2	0.95504415
39	ERBB3	0.95463272
40	EPHA4	0.95264874
41	SRPK1	0.89648843
42	AKT3	0.88494202
43	MAP2K4	0.88448982
44	PLK2	0.88251679
45	NTRK2	0.85540791
46	STK38L	0.83778096
47	ZAK	0.81898959
48	STK39	0.81680430
49	SGK2	0.78630224
50	SGK223	0.78265280
51	SGK494	0.78265280
52	ACVR1B	0.78061858
53	MAP3K9	0.76270394
54	CAMK2A	0.75212477
55	OXSR1	0.74428496
56	ADRBK1	0.71155842
57	EIF2AK3	0.69899891
58	MKNK1	0.69662075
59	CAMK2D	0.69243092
60	LIMK1	0.67891136
61	BCKDK	0.67622321
62	CAMKK2	0.65106476
63	PRKCZ	0.61609240
64	PRKCI	0.60988861
65	EPHA3	0.59744887
66	PRKCH	0.58762432
67	STK3	0.58106075
68	CAMK1G	0.57969626
69	CSNK1A1	0.57758955
70	PRKD3	0.57359064
71	UHMK1	0.55114835
72	WEE1	0.54322057
73	IRAK1	0.51464309
74	DYRK1A	0.51462682
75	STK11	0.49967201
76	HIPK2	0.48796218
77	CDK5	0.48382170
78	PKN1	0.48008606
79	PRKAA1	0.47982072
80	DYRK3	0.46241263
81	PAK6	0.45321714
82	MAP3K6	0.45108635
83	PRKACA	0.44915898
84	TAF1	0.44711928
85	CSNK1D	0.44675019
86	CDK3	0.44427338
87	NME1	0.43463092
88	PRKG1	0.40879723
89	MAPKAPK5	0.40201841
90	TSSK6	0.39727532
91	CSNK1E	0.39615695
92	MAP3K12	0.38886442
93	EIF2AK2	0.36107501
94	VRK1	0.34532370
95	PTK2B	0.34288515
96	CAMK2B	0.34199128
97	SGK1	0.32948888
98	RPS6KA5	0.32597102
99	CAMK4	0.31225153
100	MAP3K5	0.31114716

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Maturity onset diabetes of the young_Homo sapiens_hsa04950	3.25116122
2	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.07146516
3	Nicotine addiction_Homo sapiens_hsa05033	2.79567627
4	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.73185385
5	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.73139015
6	Butanoate metabolism_Homo sapiens_hsa00650	2.55846511
7	Selenocompound metabolism_Homo sapiens_hsa00450	2.43213988
8	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.39852194
9	Phototransduction_Homo sapiens_hsa04744	2.37828419
10	Protein export_Homo sapiens_hsa03060	2.22795370
11	Sulfur metabolism_Homo sapiens_hsa00920	1.94320063
12	Oxidative phosphorylation_Homo sapiens_hsa00190	1.92954235
13	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.92069524
14	Linoleic acid metabolism_Homo sapiens_hsa00591	1.89777882
15	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.82202647
16	Ether lipid metabolism_Homo sapiens_hsa00565	1.79648795
17	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.70547063
18	Insulin secretion_Homo sapiens_hsa04911	1.69510571
19	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.65147723
20	Circadian entrainment_Homo sapiens_hsa04713	1.57209592
21	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.56919730
22	Morphine addiction_Homo sapiens_hsa05032	1.55436036
23	GABAergic synapse_Homo sapiens_hsa04727	1.55241923
24	Collecting duct acid secretion_Homo sapiens_hsa04966	1.47375532
25	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.43965172
26	Parkinsons disease_Homo sapiens_hsa05012	1.43235565
27	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.42503867
28	Glutamatergic synapse_Homo sapiens_hsa04724	1.41449062
29	Propanoate metabolism_Homo sapiens_hsa00640	1.40874685
30	Dopaminergic synapse_Homo sapiens_hsa04728	1.40427965
31	Taste transduction_Homo sapiens_hsa04742	1.39282913
32	Cocaine addiction_Homo sapiens_hsa05030	1.35209130
33	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.33629386
34	Tryptophan metabolism_Homo sapiens_hsa00380	1.30764810
35	Circadian rhythm_Homo sapiens_hsa04710	1.19807805
36	Peroxisome_Homo sapiens_hsa04146	1.18726712
37	RNA polymerase_Homo sapiens_hsa03020	1.17549439
38	Regulation of autophagy_Homo sapiens_hsa04140	1.13373867
39	Serotonergic synapse_Homo sapiens_hsa04726	1.10423868
40	Steroid biosynthesis_Homo sapiens_hsa00100	1.10232772
41	Fatty acid elongation_Homo sapiens_hsa00062	1.09406156
42	Nitrogen metabolism_Homo sapiens_hsa00910	1.08114081
43	Basal transcription factors_Homo sapiens_hsa03022	1.02460868
44	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.00759948
45	Amphetamine addiction_Homo sapiens_hsa05031	0.99149825
46	Olfactory transduction_Homo sapiens_hsa04740	0.97163497
47	Fatty acid metabolism_Homo sapiens_hsa01212	0.97114168
48	Cardiac muscle contraction_Homo sapiens_hsa04260	0.93931321
49	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.93044635
50	Long-term depression_Homo sapiens_hsa04730	0.91906264
51	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.90192347
52	ABC transporters_Homo sapiens_hsa02010	0.86192794
53	beta-Alanine metabolism_Homo sapiens_hsa00410	0.86173390
54	RNA degradation_Homo sapiens_hsa03018	0.83980609
55	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.83004577
56	Alzheimers disease_Homo sapiens_hsa05010	0.82336190
57	Huntingtons disease_Homo sapiens_hsa05016	0.80573359
58	Fatty acid degradation_Homo sapiens_hsa00071	0.79732031
59	Salivary secretion_Homo sapiens_hsa04970	0.78511030
60	Caffeine metabolism_Homo sapiens_hsa00232	0.74426754
61	Purine metabolism_Homo sapiens_hsa00230	0.72335353
62	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.71265482
63	Metabolic pathways_Homo sapiens_hsa01100	0.67427704
64	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.66254680
65	Sphingolipid metabolism_Homo sapiens_hsa00600	0.65765118
66	Fat digestion and absorption_Homo sapiens_hsa04975	0.63540648
67	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.62814259
68	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.62258521
69	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.61514177
70	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.60287695
71	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.60048809
72	Chemical carcinogenesis_Homo sapiens_hsa05204	0.58817135
73	Type II diabetes mellitus_Homo sapiens_hsa04930	0.58587083
74	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.58226239
75	Folate biosynthesis_Homo sapiens_hsa00790	0.57356921
76	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.57276167
77	Cholinergic synapse_Homo sapiens_hsa04725	0.56795973
78	Renin secretion_Homo sapiens_hsa04924	0.56431691
79	One carbon pool by folate_Homo sapiens_hsa00670	0.55925349
80	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.54319341
81	Retinol metabolism_Homo sapiens_hsa00830	0.54318125
82	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.53603697
83	Calcium signaling pathway_Homo sapiens_hsa04020	0.52713830
84	Fanconi anemia pathway_Homo sapiens_hsa03460	0.50536267
85	Axon guidance_Homo sapiens_hsa04360	0.48987860
86	Vibrio cholerae infection_Homo sapiens_hsa05110	0.48418496
87	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.44096422
88	cAMP signaling pathway_Homo sapiens_hsa04024	0.43019674
89	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.42140219
90	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.42035533
91	Non-homologous end-joining_Homo sapiens_hsa03450	0.41912850
92	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.41505573
93	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.40460857
94	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.38716253
95	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.38680080
96	Gastric acid secretion_Homo sapiens_hsa04971	0.36681465
97	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.36049610
98	Pyruvate metabolism_Homo sapiens_hsa00620	0.34365647
99	Pancreatic secretion_Homo sapiens_hsa04972	0.32967431
100	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.29059558

NAT16

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »