NAT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in this gene are also associated with higher incidences of cancer and drug toxicity. A second arylamine N-acetyltransferase gene (NAT1) is located near this gene (NAT2). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epoxygenase P450 pathway (GO:0019373)9.35136007
2exogenous drug catabolic process (GO:0042738)8.99750024
3omega-hydroxylase P450 pathway (GO:0097267)7.76934769
4drug metabolic process (GO:0017144)6.75536592
5L-phenylalanine catabolic process (GO:0006559)5.75264412
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.75264412
7L-phenylalanine metabolic process (GO:0006558)5.57952516
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.57952516
9oxidative demethylation (GO:0070989)5.45891441
10aromatic amino acid family catabolic process (GO:0009074)5.35564304
11fat-soluble vitamin biosynthetic process (GO:0042362)5.29026854
12phenylpropanoid metabolic process (GO:0009698)5.27837615
13triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.19993820
14hormone catabolic process (GO:0042447)4.98370101
15tryptophan catabolic process (GO:0006569)4.92119543
16indole-containing compound catabolic process (GO:0042436)4.92119543
17indolalkylamine catabolic process (GO:0046218)4.92119543
18bile acid biosynthetic process (GO:0006699)4.78184460
19kynurenine metabolic process (GO:0070189)4.75199336
20cysteine metabolic process (GO:0006534)4.70523815
21tryptophan metabolic process (GO:0006568)4.66833204
22glyoxylate metabolic process (GO:0046487)4.60967161
23urea cycle (GO:0000050)4.50766202
24urea metabolic process (GO:0019627)4.50766202
25sulfur amino acid catabolic process (GO:0000098)4.49285781
26alpha-linolenic acid metabolic process (GO:0036109)4.45417752
27alkaloid metabolic process (GO:0009820)4.43144195
28high-density lipoprotein particle remodeling (GO:0034375)4.41716176
29complement activation, alternative pathway (GO:0006957)4.38607545
30arginine metabolic process (GO:0006525)4.29798678
31regulation of bile acid biosynthetic process (GO:0070857)4.27281935
32negative regulation of hemostasis (GO:1900047)4.27205017
33negative regulation of blood coagulation (GO:0030195)4.27205017
34fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.24620220
35regulation of protein activation cascade (GO:2000257)4.23602947
36negative regulation of fibrinolysis (GO:0051918)4.22824985
37heme transport (GO:0015886)4.17822238
38intestinal absorption (GO:0050892)4.16595451
39peptidyl-glutamic acid carboxylation (GO:0017187)4.16567824
40protein carboxylation (GO:0018214)4.16567824
41nitrogen cycle metabolic process (GO:0071941)4.15800605
42regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.14390703
43regulation of triglyceride catabolic process (GO:0010896)4.11255021
44ethanol oxidation (GO:0006069)4.08268746
45lysine catabolic process (GO:0006554)4.07399347
46lysine metabolic process (GO:0006553)4.07399347
47regulation of plasminogen activation (GO:0010755)4.03472070
48regulation of fibrinolysis (GO:0051917)4.02307536
49bile acid metabolic process (GO:0008206)4.02050257
50regulation of complement activation (GO:0030449)3.98155150
51regulation of cholesterol esterification (GO:0010872)3.92923012
52negative regulation of coagulation (GO:0050819)3.90907747
53S-adenosylmethionine metabolic process (GO:0046500)3.88293706
54negative regulation of wound healing (GO:0061045)3.85015818
55phospholipid efflux (GO:0033700)3.84720852
56aromatic amino acid family metabolic process (GO:0009072)3.82998629
57negative regulation of sterol transport (GO:0032372)3.82829257
58negative regulation of cholesterol transport (GO:0032375)3.82829257
59regulation of humoral immune response (GO:0002920)3.82279763
60amino-acid betaine metabolic process (GO:0006577)3.78849899
61protein-lipid complex remodeling (GO:0034368)3.78830031
62macromolecular complex remodeling (GO:0034367)3.78830031
63plasma lipoprotein particle remodeling (GO:0034369)3.78830031
64aldehyde catabolic process (GO:0046185)3.76820679
65reverse cholesterol transport (GO:0043691)3.76427199
66bile acid and bile salt transport (GO:0015721)3.73595068
67angiotensin maturation (GO:0002003)3.68944801
68negative regulation of lipase activity (GO:0060192)3.65988486
69* xenobiotic metabolic process (GO:0006805)3.65622517
70valine metabolic process (GO:0006573)3.65552152
71serine family amino acid catabolic process (GO:0009071)3.63354015
72imidazole-containing compound metabolic process (GO:0052803)3.62576542
73negative regulation of protein activation cascade (GO:2000258)3.61406401
74cellular glucuronidation (GO:0052695)3.60703194
75acylglycerol homeostasis (GO:0055090)3.60372689
76triglyceride homeostasis (GO:0070328)3.60372689
77plasma lipoprotein particle assembly (GO:0034377)3.57399225
78homocysteine metabolic process (GO:0050667)3.57326802
79drug transport (GO:0015893)3.55159427
80lipoprotein transport (GO:0042953)3.54371511
81alpha-amino acid catabolic process (GO:1901606)3.53158368
82plasma lipoprotein particle clearance (GO:0034381)3.52384093
83positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.51422721
84tyrosine metabolic process (GO:0006570)3.48614811
85glycine metabolic process (GO:0006544)3.47779732
86killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.47160363
87disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.47160363
88response to nitrosative stress (GO:0051409)3.46865026
89amine catabolic process (GO:0009310)3.45470412
90cellular biogenic amine catabolic process (GO:0042402)3.45470412
91benzene-containing compound metabolic process (GO:0042537)3.42301008
92indolalkylamine metabolic process (GO:0006586)3.42284066
93cytolysis (GO:0019835)3.41854764
94polyketide metabolic process (GO:0030638)3.41573392
95doxorubicin metabolic process (GO:0044598)3.41573392
96daunorubicin metabolic process (GO:0044597)3.41573392
97serine family amino acid metabolic process (GO:0009069)3.40907237
98serine family amino acid biosynthetic process (GO:0009070)3.39989403
99cholesterol efflux (GO:0033344)3.37245195
100very-low-density lipoprotein particle assembly (GO:0034379)3.36420018
101fructose metabolic process (GO:0006000)3.35267454
102vitamin biosynthetic process (GO:0009110)3.33536476
103lipoprotein metabolic process (GO:0042157)3.32754134
104positive regulation of triglyceride lipase activity (GO:0061365)3.32414297
105positive regulation of lipoprotein lipase activity (GO:0051006)3.32414297
106ethanol metabolic process (GO:0006067)3.30544697
107cofactor catabolic process (GO:0051187)3.27457058
108uronic acid metabolic process (GO:0006063)3.26272388
109glucuronate metabolic process (GO:0019585)3.26272388
110coenzyme catabolic process (GO:0009109)3.25955472
111protein-lipid complex assembly (GO:0065005)3.24483926
112cellular amino acid catabolic process (GO:0009063)3.23956878
113drug transmembrane transport (GO:0006855)3.22006350
114drug catabolic process (GO:0042737)3.21703181
115blood coagulation, intrinsic pathway (GO:0007597)3.21389027
116complement activation, classical pathway (GO:0006958)3.20340339
117protein activation cascade (GO:0072376)3.17588242
118complement activation (GO:0006956)3.17319965
119fibrinolysis (GO:0042730)3.15626477
120primary alcohol catabolic process (GO:0034310)3.15026672
121flavonoid metabolic process (GO:0009812)3.13488483
122urate metabolic process (GO:0046415)3.13032050
123regulation of cholesterol metabolic process (GO:0090181)3.12937649
124intestinal cholesterol absorption (GO:0030299)3.12842784
125cellular modified amino acid catabolic process (GO:0042219)3.10686483
126glutamate metabolic process (GO:0006536)3.10244688
127opsonization (GO:0008228)3.09994090
128cholesterol homeostasis (GO:0042632)3.09671148
129low-density lipoprotein particle remodeling (GO:0034374)3.06617439
130plasma lipoprotein particle organization (GO:0071827)3.06543521
131positive regulation of lipid catabolic process (GO:0050996)3.03939562
132regulation of cholesterol biosynthetic process (GO:0045540)3.03907638
133acute-phase response (GO:0006953)3.03541266
134sterol homeostasis (GO:0055092)3.02969441
135cellular ketone body metabolic process (GO:0046950)3.02743099
136pyridine nucleotide biosynthetic process (GO:0019363)2.97974053
137nicotinamide nucleotide biosynthetic process (GO:0019359)2.97974053

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.05807317
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.58552242
3EGR1_23403033_ChIP-Seq_LIVER_Mouse5.01547153
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.93796550
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.12813727
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.83634543
7IRF8_22096565_ChIP-ChIP_GC-B_Human3.79050214
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.73711887
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.22595837
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.03667649
11GATA1_22025678_ChIP-Seq_K562_Human2.94445470
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.82783856
13CDX2_20551321_ChIP-Seq_CACO-2_Human2.68386329
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.42176598
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.37690038
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.14556199
17NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.03147873
18HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.95315669
19FOXA2_19822575_ChIP-Seq_HepG2_Human1.90492351
20SCL_19346495_ChIP-Seq_HPC-7_Human1.89429894
21EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.85631634
22* IRF8_21731497_ChIP-ChIP_J774_Mouse1.81808887
23TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81688183
24ELF1_17652178_ChIP-ChIP_JURKAT_Human1.81435000
25STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.79131448
26MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.76976887
27MYB_21317192_ChIP-Seq_ERMYB_Mouse1.70748609
28TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.69639051
29HTT_18923047_ChIP-ChIP_STHdh_Human1.68204656
30TRIM28_21343339_ChIP-Seq_HEK293_Human1.66321592
31NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.64480567
32AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.60482794
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.54913674
34GATA6_25053715_ChIP-Seq_YYC3_Human1.54351776
35BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.53975042
36RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.52074471
37* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.50653775
38TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.48688971
39SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.45573908
40NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.44702634
41RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.43815152
42IRF8_27001747_Chip-Seq_BMDM_Mouse1.42175479
43STAT4_19710469_ChIP-ChIP_TH1__Mouse1.40837160
44FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.39479324
45CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.36151808
46BRD4_27068464_Chip-Seq_AML-cells_Mouse1.33952282
47SOX2_20726797_ChIP-Seq_SW620_Human1.32243665
48FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.30734893
49CDX2_19796622_ChIP-Seq_MESCs_Mouse1.30089150
50STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.24351938
51MYB_26560356_Chip-Seq_TH2_Human1.19503216
52FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.19195900
53MAF_26560356_Chip-Seq_TH1_Human1.17132460
54GATA2_22383799_ChIP-Seq_G1ME_Mouse1.15237140
55TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.14633709
56FOXO3_23340844_ChIP-Seq_DLD1_Human1.14418226
57MYB_26560356_Chip-Seq_TH1_Human1.14366726
58GATA1_22383799_ChIP-Seq_G1ME_Mouse1.13717713
59CLOCK_20551151_ChIP-Seq_293T_Human1.13286546
60FOXA1_25552417_ChIP-Seq_VCAP_Human1.12217072
61CDX2_22108803_ChIP-Seq_LS180_Human1.10940330
62TP63_17297297_ChIP-ChIP_HaCaT_Human1.10873810
63SPI1_23547873_ChIP-Seq_NB4_Human1.08361505
64FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.07821376
65STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.07463340
66STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.07252638
67VDR_21846776_ChIP-Seq_THP-1_Human1.06264386
68CBP_21632823_ChIP-Seq_H3396_Human1.06015669
69RUNX1_22412390_ChIP-Seq_EML_Mouse1.05789679
70ESR1_15608294_ChIP-ChIP_MCF-7_Human1.05258779
71UTX_26944678_Chip-Seq_JUKART_Human1.04200004
72SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.03909870
73ERG_20887958_ChIP-Seq_HPC-7_Mouse1.03324282
74PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03101724
75MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.02525269
76MYC_22102868_ChIP-Seq_BL_Human1.02128820
77EGR1_19374776_ChIP-ChIP_THP-1_Human1.01437030
78KAP1_22055183_ChIP-Seq_ESCs_Mouse0.98800044
79HOXB4_20404135_ChIP-ChIP_EML_Mouse0.98076281
80BP1_19119308_ChIP-ChIP_Hs578T_Human0.98037488
81NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.97910756
82TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97083843
83GATA1_19941827_ChIP-Seq_MEL_Mouse0.97024511
84ESR1_20079471_ChIP-ChIP_T-47D_Human0.96989929
85HNFA_21074721_ChIP-Seq_CACO-2_Human0.96814347
86CEBPB_22108803_ChIP-Seq_LS180_Human0.96795202
87BCAT_22108803_ChIP-Seq_LS180_Human0.96136211
88THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.95475190
89STAT3_1855785_ChIP-Seq_MESCs_Mouse0.94802577
90ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93941612
91AR_20517297_ChIP-Seq_VCAP_Human0.93826162
92TCF4_18268006_ChIP-ChIP_LS174T_Human0.93387418
93NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.93283360
94ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.93239681
95Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.93186159
96PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.92690527
97CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.92665649
98PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.92265238
99GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.91577395
100GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.90380424
101ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88872223
102LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.88316016
103GABP_17652178_ChIP-ChIP_JURKAT_Human0.87985937
104CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87452408
105GATA4_25053715_ChIP-Seq_YYC3_Human0.87405241
106NOTCH1_21737748_ChIP-Seq_TLL_Human0.87349127
107CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.85595929
108FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.85370998
109VDR_24763502_ChIP-Seq_THP-1_Human0.85091004
110SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.84775864
111SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.84521537
112LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.83995484
113FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.83979361
114SOX2_27498859_Chip-Seq_STOMACH_Mouse0.83391728
115CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83338915
116MYC_18555785_ChIP-Seq_MESCs_Mouse0.83284454
117E2F7_22180533_ChIP-Seq_HELA_Human0.82566502
118PPAR_26484153_Chip-Seq_NCI-H1993_Human0.81719605
119SRF_21415370_ChIP-Seq_HL-1_Mouse0.81120091
120TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81070609
121GATA1_19941826_ChIP-Seq_K562_Human0.80670789
122BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.80438235
123RUNX_20019798_ChIP-Seq_JUKART_Human0.80350749
124AR_21909140_ChIP-Seq_LNCAP_Human0.80250151
125HNF4A_19822575_ChIP-Seq_HepG2_Human0.80038596
126E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.80027064
127CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.79709381
128SALL4_18804426_ChIP-ChIP_XEN_Mouse0.79515020
129MAF_26560356_Chip-Seq_TH2_Human0.79400169
130MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.79308965
131NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.79275853
132PHF8_20622853_ChIP-Seq_HELA_Human0.79266961
133PU_27001747_Chip-Seq_BMDM_Mouse0.79082379
134SOX2_21211035_ChIP-Seq_LN229_Human0.78141938
135RXRA_24833708_ChIP-Seq_LIVER_Mouse0.77848160
136ESR2_21235772_ChIP-Seq_MCF-7_Human0.77404627
137FOXP3_21729870_ChIP-Seq_TREG_Human0.76714033
138ZNF263_19887448_ChIP-Seq_K562_Human0.76136209
139CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.75412230
140TP53_18474530_ChIP-ChIP_U2OS_Human0.74190911
141SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.73981462
142GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.73183171
143EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.72641815
144E2F1_18555785_ChIP-Seq_MESCs_Mouse0.72635404
145NFYA_21822215_ChIP-Seq_K562_Human0.72566332
146NANOG_20526341_ChIP-Seq_ESCs_Human0.72327588
147AUTS2_25519132_ChIP-Seq_293T-REX_Human0.71171325
148GATA3_24758297_ChIP-Seq_MCF-7_Human0.70492191
149FOXA1_21572438_ChIP-Seq_LNCaP_Human0.69992416
150IRF1_19129219_ChIP-ChIP_H3396_Human0.68438136
151PIAS1_25552417_ChIP-Seq_VCAP_Human0.64731079
152NFE2_27457419_Chip-Seq_LIVER_Mouse0.63801085
153GATA6_21074721_ChIP-Seq_CACO-2_Human0.63413794
154AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.62906716
155PCGF2_27294783_Chip-Seq_NPCs_Mouse0.62388445
156CBX2_22325352_ChIP-Seq_293T-Rex_Human0.61271405
157TCF4_22108803_ChIP-Seq_LS180_Human0.59638725
158NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.59512384
159PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.58991991
160ETV1_20927104_ChIP-Seq_GIST48_Human0.58662701
161P53_21459846_ChIP-Seq_SAOS-2_Human0.57797945
162RAD21_21589869_ChIP-Seq_MESCs_Mouse0.57635982
163EZH2_27294783_Chip-Seq_NPCs_Mouse0.55753801
164ERG_20517297_ChIP-Seq_VCAP_Human0.55720543
165TP63_23658742_ChIP-Seq_EP156T_Human0.55207105
166TAF2_19829295_ChIP-Seq_ESCs_Human0.54692033
167SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.54584241
168EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.54510800
169CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.53901951
170SOX2_22085726_ChIP-Seq_NPCs_Mouse0.53713449

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.24541077
2MP0005360_urolithiasis6.08532349
3MP0005365_abnormal_bile_salt4.72647832
4MP0005085_abnormal_gallbladder_physiolo4.69894766
5* MP0008875_abnormal_xenobiotic_pharmacok4.00193628
6MP0003806_abnormal_nucleotide_metabolis3.70998176
7MP0003252_abnormal_bile_duct3.03434906
8MP0009840_abnormal_foam_cell2.70153208
9MP0010329_abnormal_lipoprotein_level2.69971475
10MP0001666_abnormal_nutrient_absorption2.30168558
11MP0005083_abnormal_biliary_tract2.10948946
12MP0005332_abnormal_amino_acid2.07648396
13MP0003656_abnormal_erythrocyte_physiolo2.06243571
14MP0003191_abnormal_cellular_cholesterol2.01867810
15MP0003186_abnormal_redox_activity2.01424278
16MP0003195_calcinosis1.99064115
17MP0000609_abnormal_liver_physiology1.93725636
18MP0001835_abnormal_antigen_presentation1.87998745
19MP0002876_abnormal_thyroid_physiology1.78934983
20MP0005319_abnormal_enzyme/_coenzyme1.71960555
21MP0003183_abnormal_peptide_metabolism1.71604059
22MP0003436_decreased_susceptibility_to1.68716424
23MP0004019_abnormal_vitamin_homeostasis1.62666033
24MP0009785_altered_susceptibility_to1.60252799
25MP0003724_increased_susceptibility_to1.57973487
26MP0002118_abnormal_lipid_homeostasis1.55222504
27MP0002132_abnormal_respiratory_system1.54202976
28MP0002138_abnormal_hepatobiliary_system1.52210845
29MP0005464_abnormal_platelet_physiology1.51325396
30MP0003718_maternal_effect1.45624435
31MP0005584_abnormal_enzyme/coenzyme_acti1.44079484
32MP0008469_abnormal_protein_level1.43782397
33MP0000685_abnormal_immune_system1.40974412
34MP0009764_decreased_sensitivity_to1.38775928
35MP0005670_abnormal_white_adipose1.38524739
36MP0005025_abnormal_response_to1.37847276
37MP0009643_abnormal_urine_homeostasis1.35942834
38MP0005671_abnormal_response_to1.32855962
39MP0001853_heart_inflammation1.32433307
40MP0001764_abnormal_homeostasis1.31877811
41MP0003868_abnormal_feces_composition1.31850562
42MP0001800_abnormal_humoral_immune1.29742009
43MP0009697_abnormal_copulation1.28041517
44MP0000598_abnormal_liver_morphology1.26957956
45MP0009763_increased_sensitivity_to1.26426790
46MP0002419_abnormal_innate_immunity1.25987603
47MP0002166_altered_tumor_susceptibility1.24193018
48MP0006082_CNS_inflammation1.22794012
49MP0010234_abnormal_vibrissa_follicle1.15628485
50MP0005000_abnormal_immune_tolerance1.12844305
51MP0004147_increased_porphyrin_level1.12469953
52MP0005451_abnormal_body_composition1.11925986
53MP0010155_abnormal_intestine_physiology1.11212340
54MP0001845_abnormal_inflammatory_respons1.09188396
55MP0002396_abnormal_hematopoietic_system1.08525629
56MP0002723_abnormal_immune_serum1.08518075
57MP0005636_abnormal_mineral_homeostasis1.08454593
58MP0002452_abnormal_antigen_presenting1.07846095
59MP0003300_gastrointestinal_ulcer1.07235860
60MP0001790_abnormal_immune_system1.05958731
61MP0005387_immune_system_phenotype1.05958731
62MP0003763_abnormal_thymus_physiology1.04792724
63MP0005408_hypopigmentation1.01672342
64MP0004947_skin_inflammation1.01629117
65MP0004264_abnormal_extraembryonic_tissu0.99976620
66MP0009765_abnormal_xenobiotic_induced0.96508181
67MP0003879_abnormal_hair_cell0.95600252
68MP0006054_spinal_hemorrhage0.95578000
69MP0005397_hematopoietic_system_phenotyp0.95175368
70MP0001545_abnormal_hematopoietic_system0.95175368
71MP0002420_abnormal_adaptive_immunity0.94788483
72MP0005395_other_phenotype0.94617564
73MP0002148_abnormal_hypersensitivity_rea0.94148006
74MP0001819_abnormal_immune_cell0.93760399
75MP0000689_abnormal_spleen_morphology0.93586907
76MP0010368_abnormal_lymphatic_system0.89742197
77MP0002398_abnormal_bone_marrow0.87484551
78MP0009642_abnormal_blood_homeostasis0.85626533
79MP0002136_abnormal_kidney_physiology0.83870576
80MP0002006_tumorigenesis0.83850814
81MP0000716_abnormal_immune_system0.83535948
82MP0002722_abnormal_immune_system0.82710555
83MP0002971_abnormal_brown_adipose0.82332564
84MP0006036_abnormal_mitochondrial_physio0.80481505
85MP0002405_respiratory_system_inflammati0.79613350
86MP0005023_abnormal_wound_healing0.79468551
87MP0005058_abnormal_lysosome_morphology0.78948147
88MP0002429_abnormal_blood_cell0.78447880
89MP0001873_stomach_inflammation0.78194297
90MP0005084_abnormal_gallbladder_morpholo0.75689715
91MP0005535_abnormal_body_temperature0.75192762
92MP0002254_reproductive_system_inflammat0.72836159
93MP0005220_abnormal_exocrine_pancreas0.72467064
94MP0001533_abnormal_skeleton_physiology0.72430853
95MP0009333_abnormal_splenocyte_physiolog0.72101829
96MP0002928_abnormal_bile_duct0.71983300
97MP0008872_abnormal_physiological_respon0.71454438
98MP0000604_amyloidosis0.69556980
99MP0003705_abnormal_hypodermis_morpholog0.69092455
100MP0005166_decreased_susceptibility_to0.67845892
101MP0003011_delayed_dark_adaptation0.67594999
102MP0008873_increased_physiological_sensi0.66567221
103MP0005647_abnormal_sex_gland0.65553183
104* MP0005376_homeostasis/metabolism_phenot0.64940524
105MP0009379_abnormal_foot_pigmentation0.64511907
106MP0004043_abnormal_pH_regulation0.63798406
107MP0010352_gastrointestinal_tract_polyps0.63504679
108MP0003638_abnormal_response/metabolism_0.62762353
109MP0005409_darkened_coat_color0.62530917
110MP0005075_abnormal_melanosome_morpholog0.62418120
111MP0001664_abnormal_digestion0.61749808
112MP0003303_peritoneal_inflammation0.61601615
113MP0004130_abnormal_muscle_cell0.60485364
114MP0000490_abnormal_crypts_of0.59687463
115MP0001756_abnormal_urination0.57347214
116MP0002078_abnormal_glucose_homeostasis0.57299490
117MP0005334_abnormal_fat_pad0.56377683
118MP0004782_abnormal_surfactant_physiolog0.54961379
119MP0003866_abnormal_defecation0.54575815
120MP0000477_abnormal_intestine_morphology0.53346378
121MP0005448_abnormal_energy_balance0.53200112
122MP0000566_synostosis0.49176016
123MP0001661_extended_life_span0.48858702
124MP0001765_abnormal_ion_homeostasis0.48230816
125MP0009053_abnormal_anal_canal0.47679245
126MP0009115_abnormal_fat_cell0.45634201
127MP0000249_abnormal_blood_vessel0.45446218
128MP0005187_abnormal_penis_morphology0.43234799
129MP0000678_abnormal_parathyroid_gland0.40085119
130MP0002249_abnormal_larynx_morphology0.40077943
131MP0001663_abnormal_digestive_system0.39629940
132MP0003953_abnormal_hormone_level0.38689860
133MP0001986_abnormal_taste_sensitivity0.37773312
134MP0001881_abnormal_mammary_gland0.37731039
135MP0008874_decreased_physiological_sensi0.35154873
136MP0002822_catalepsy0.31092612
137MP0000538_abnormal_urinary_bladder0.29784486
138MP0002796_impaired_skin_barrier0.29753397
139MP0005381_digestive/alimentary_phenotyp0.29611193
140MP0000467_abnormal_esophagus_morphology0.29152343
141MP0000230_abnormal_systemic_arterial0.27508805
142MP0002168_other_aberrant_phenotype0.27486680
143MP0005666_abnormal_adipose_tissue0.26691686
144* MP0005266_abnormal_metabolism0.26470321
145MP0001915_intracranial_hemorrhage0.26264945
146MP0003941_abnormal_skin_development0.24318873
147MP0002098_abnormal_vibrissa_morphology0.22458476

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.91188597
2Intrahepatic cholestasis (HP:0001406)5.71849403
3Deep venous thrombosis (HP:0002625)5.40637994
4Abnormality of monocarboxylic acid metabolism (HP:0010996)5.27984260
5Hypobetalipoproteinemia (HP:0003563)5.23308968
6Xanthomatosis (HP:0000991)5.16019760
7Prolonged partial thromboplastin time (HP:0003645)4.99203360
8Hyperlipoproteinemia (HP:0010980)4.34039039
9Complement deficiency (HP:0004431)4.10909991
10Joint hemorrhage (HP:0005261)3.81905141
11Abnormality of the common coagulation pathway (HP:0010990)3.75034306
12Abnormality of glutamine family amino acid metabolism (HP:0010902)3.73143339
13Hyperammonemia (HP:0001987)3.72897001
14Hypolipoproteinemia (HP:0010981)3.69382920
15Fat malabsorption (HP:0002630)3.62537905
16Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.47428267
17Epidermoid cyst (HP:0200040)3.41869575
18Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.39110492
19Nephritis (HP:0000123)3.38277495
20Ketosis (HP:0001946)3.37557341
21Abnormality of fatty-acid metabolism (HP:0004359)3.31942379
22Hyperbilirubinemia (HP:0002904)3.28706053
23Abnormality of aspartate family amino acid metabolism (HP:0010899)3.27834655
24Abnormality of complement system (HP:0005339)3.22792819
25Abnormality of sulfur amino acid metabolism (HP:0004339)3.21595915
26Recurrent gram-negative bacterial infections (HP:0005420)3.21159763
27Conjugated hyperbilirubinemia (HP:0002908)3.17823242
28Hypoglycemic coma (HP:0001325)3.16949084
29Abnormality of vitamin metabolism (HP:0100508)3.15549915
30Hypercholesterolemia (HP:0003124)3.15193169
31Abnormality of pyrimidine metabolism (HP:0004353)3.12221601
32Hyperglycinuria (HP:0003108)3.10410741
33Abnormality of methionine metabolism (HP:0010901)3.08532451
34Abnormality of the intrinsic pathway (HP:0010989)2.97832843
35Hypoalphalipoproteinemia (HP:0003233)2.94864932
36Abnormality of glycine metabolism (HP:0010895)2.93405572
37Abnormality of serine family amino acid metabolism (HP:0010894)2.93405572
38Acanthocytosis (HP:0001927)2.92891676
39Osteomalacia (HP:0002749)2.92435297
40Rickets (HP:0002748)2.91713686
41Myocardial infarction (HP:0001658)2.90332791
42Abnormality of urine glucose concentration (HP:0011016)2.88624272
43Glycosuria (HP:0003076)2.88624272
44Hepatocellular carcinoma (HP:0001402)2.86314783
45Steatorrhea (HP:0002570)2.86267966
46Hyperglycinemia (HP:0002154)2.74632911
47Hemorrhage of the eye (HP:0011885)2.66880641
48Abnormality of nucleobase metabolism (HP:0010932)2.63817782
49Hyperphosphaturia (HP:0003109)2.59419145
50Gingival bleeding (HP:0000225)2.55841930
51Systemic lupus erythematosus (HP:0002725)2.55009089
52Hypoplasia of the thymus (HP:0000778)2.52928955
53Alkalosis (HP:0001948)2.47651248
54Delayed CNS myelination (HP:0002188)2.45944966
55Abnormality of the heme biosynthetic pathway (HP:0010472)2.45912747
56Abnormality of iron homeostasis (HP:0011031)2.45326336
57Ketoacidosis (HP:0001993)2.43931974
58Mitral stenosis (HP:0001718)2.41636311
59Poikilocytosis (HP:0004447)2.41407289
60Abnormality of purine metabolism (HP:0004352)2.39615872
61Generalized aminoaciduria (HP:0002909)2.39121568
62Abnormal urine phosphate concentration (HP:0012599)2.37472192
63Metabolic acidosis (HP:0001942)2.34804617
64Abnormality of transition element cation homeostasis (HP:0011030)2.34743482
65Irritability (HP:0000737)2.29880453
66Spontaneous abortion (HP:0005268)2.29477051
67Abnormality of serum amino acid levels (HP:0003112)2.27779100
68Dicarboxylic aciduria (HP:0003215)2.25833729
69Abnormality of dicarboxylic acid metabolism (HP:0010995)2.25833729
70Increased serum ferritin (HP:0003281)2.25397097
71Proximal tubulopathy (HP:0000114)2.25044268
72Autoimmune thrombocytopenia (HP:0001973)2.23018183
73Pancreatitis (HP:0001733)2.22857821
74Thrombophlebitis (HP:0004418)2.22561073
75Eczematoid dermatitis (HP:0000976)2.21668738
76Renal cortical cysts (HP:0000803)2.20784790
77Abnormality of the vitamin B12 metabolism (HP:0004341)2.16627169
78Elevated alkaline phosphatase (HP:0003155)2.14553152
79Spastic diplegia (HP:0001264)2.14484634
80Hypophosphatemic rickets (HP:0004912)2.13267911
81Epistaxis (HP:0000421)2.12879817
82Cerebral palsy (HP:0100021)2.12796100
83Abnormal enzyme/coenzyme activity (HP:0012379)2.12453395
84Widely patent fontanelles and sutures (HP:0004492)2.12147055
85Esophageal varix (HP:0002040)2.11307532
86Nausea (HP:0002018)2.10528873
87Lethargy (HP:0001254)2.09358348
88Recurrent bacterial skin infections (HP:0005406)2.09123779
89Abnormality of alkaline phosphatase activity (HP:0004379)2.08653217
90Hypochromic microcytic anemia (HP:0004840)2.08128902
91Nephrolithiasis (HP:0000787)2.07420963
92Hyperactive renin-angiotensin system (HP:0000841)2.06935740
93Menorrhagia (HP:0000132)2.05054688
94Abnormality of vitamin B metabolism (HP:0004340)2.05014116
95Vascular calcification (HP:0004934)2.04339204
96Reduced antithrombin III activity (HP:0001976)2.00100966
97Malnutrition (HP:0004395)1.99611304
98Impaired platelet aggregation (HP:0003540)1.99102511
99Abnormal platelet function (HP:0011869)1.99102511
100Hydroxyprolinuria (HP:0003080)1.99012147
101Abnormality of proline metabolism (HP:0010907)1.99012147
102Abnormal tarsal ossification (HP:0008369)1.98044758
103Microcytic anemia (HP:0001935)1.97679247
104Glomerulonephritis (HP:0000099)1.96714062
105Megaloblastic anemia (HP:0001889)1.95526741
106Confusion (HP:0001289)1.95510138
107Hypophosphatemia (HP:0002148)1.95293919
108Recurrent skin infections (HP:0001581)1.94780986
109Brushfield spots (HP:0001088)1.93941167
110Abnormal gallbladder morphology (HP:0012437)1.93755344
111Ileus (HP:0002595)1.93641072
112Fair hair (HP:0002286)1.93385880
113Gout (HP:0001997)1.93259903
114Elevated hepatic transaminases (HP:0002910)1.92410369
115Elevated erythrocyte sedimentation rate (HP:0003565)1.92223125
116Abdominal distention (HP:0003270)1.88820394
117Cholelithiasis (HP:0001081)1.88698914
118Abnormal cartilage morphology (HP:0002763)1.88697915
119Neonatal hypoglycemia (HP:0001998)1.88274210
120Abnormal platelet volume (HP:0011876)1.88053208
121Skin nodule (HP:0200036)1.87905959
122Hypertriglyceridemia (HP:0002155)1.87652869
123Pulmonary embolism (HP:0002204)1.86066403
124Pigmentary retinal degeneration (HP:0001146)1.85363122
125Increased mean platelet volume (HP:0011877)1.84680904
126Vomiting (HP:0002013)1.84158024
127Abnormal gallbladder physiology (HP:0012438)1.83624175
128Cholecystitis (HP:0001082)1.83624175
129Abnormality of T cell physiology (HP:0011840)1.83081445
130Cerebral edema (HP:0002181)1.82342155
131Pustule (HP:0200039)1.82082934
132Amyloidosis (HP:0011034)1.81972300
133Cardiovascular calcification (HP:0011915)1.81044576
134Joint swelling (HP:0001386)1.76408935
135Facial shape deformation (HP:0011334)1.74217867
136Potter facies (HP:0002009)1.74217867
137Purpura (HP:0000979)1.73117150

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK13.92813135
2FGFR43.68556528
3BCKDK3.49761171
4NME23.21728809
5ERN13.16618778
6PIK3CA3.10183915
7BRD42.90960543
8MAP4K12.71533635
9TYK22.58068394
10TAOK32.56478791
11MAP3K122.48228259
12EPHA22.40822291
13MET2.26439439
14TBK12.21718330
15ACVR1B2.17896752
16MAP3K142.08689424
17KIT2.07517710
18IKBKE1.97007859
19JAK31.86835055
20PDK21.85242496
21MAP2K31.81474204
22TEC1.78355657
23TXK1.76485817
24FLT31.73833386
25IRAK41.69002940
26STK391.67420278
27SIK11.65024294
28KDR1.62806623
29LMTK21.61078081
30MST1R1.60950738
31MAP3K131.60434868
32PIK3CG1.57580125
33BTK1.55632064
34PRKACG1.52638722
35GRK61.52184427
36MAP3K31.50284882
37FGFR31.46062117
38STK101.45092247
39MAPK111.41351312
40ZAP701.40859332
41MAP3K101.39864129
42ITK1.37537488
43MYLK1.36788203
44NEK91.32412799
45ARAF1.31273583
46OXSR11.30697969
47TNIK1.29824292
48MAP3K21.29005481
49JAK11.27671256
50LRRK21.27180539
51STK241.26137860
52CSF1R1.25892038
53TGFBR11.24562021
54PRPF4B1.24085329
55PIM21.20921257
56RPS6KA41.20069911
57PDPK11.16474124
58FER1.12131101
59TGFBR21.11308986
60FRK1.10546219
61TRIB31.09388599
62MAP3K11.08713982
63EPHB11.07928036
64EPHA31.07198878
65PKN21.05883553
66BLK1.05604332
67KSR21.04562424
68IKBKB1.04185194
69SYK1.00605345
70NEK60.98599762
71JAK20.97835878
72EPHB20.97509922
73ERBB20.95841388
74TIE10.95046852
75LYN0.94495579
76EEF2K0.92869290
77CDK60.90230224
78PBK0.89204219
79PRKCZ0.88392801
80EPHA40.88249094
81NLK0.87165681
82RPS6KB20.84714912
83DYRK1B0.82604205
84AKT30.81511120
85PDK10.79048527
86CASK0.74131809
87BRSK20.73696331
88ERBB40.73530128
89MAP3K110.73492420
90LCK0.73042246
91MAP2K40.72521785
92PIM10.72282105
93MAPK40.71415838
94MAP3K70.71376753
95STK40.71239943
96PRKCA0.69118234
97MST40.67058869
98ABL20.66386624
99CSK0.66239873
100MAPK150.63852898
101FGFR20.62350689
102PRKG10.60509242
103RET0.59795691
104HCK0.59005812
105PRKAA20.58098406
106PTK60.57833380
107MAP3K90.57516335
108SCYL20.56864445
109TTK0.55822440
110TESK10.54489764
111PTK20.53636022
112PRKACA0.52673816
113CDK90.52557061
114STK160.52307214
115TRPM70.51389680
116SRC0.50918629
117BRAF0.47357953
118CHUK0.46724657
119TESK20.46070298
120GRK10.45347483
121MATK0.45218403
122MAP3K80.44644017
123IRAK30.43635551
124CAMK2D0.43615998
125MAP2K20.42952136
126CDK40.41988612
127INSRR0.41473210
128MAP3K50.40681604
129CAMK2G0.39877356
130CSNK1A10.38574016
131PRKCQ0.38476961
132PRKCB0.38025820
133PRKCI0.37828060
134EIF2AK30.36371249
135ABL10.36088951
136MAPKAPK30.35826710
137BCR0.32238595
138RPS6KA50.32092729
139PRKG20.31120177
140IRAK10.30859682
141CSNK1E0.30816341
142IGF1R0.30482766
143PRKCD0.30087332
144PAK40.28379674
145BMPR20.27818644
146BMPR1B0.27550139
147PRKAA10.27193701
148MAPK120.25490698
149EGFR0.25425229
150MAP2K60.25255560
151MAPK70.24849409
152PRKACB0.23605892
153EIF2AK10.23039652
154MAP3K60.22936892
155MAPK30.22714156

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.12285242
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.48690505
3Nitrogen metabolism_Homo sapiens_hsa009102.78228551
4Pentose and glucuronate interconversions_Homo sapiens_hsa000402.62704461
5Complement and coagulation cascades_Homo sapiens_hsa046102.52582324
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.47915215
7Arginine biosynthesis_Homo sapiens_hsa002202.39768854
8Fatty acid degradation_Homo sapiens_hsa000712.37091966
9Tryptophan metabolism_Homo sapiens_hsa003802.36000469
10* Caffeine metabolism_Homo sapiens_hsa002322.32248124
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.22107439
12Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.19339660
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.14968287
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.13226439
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.12747064
16Peroxisome_Homo sapiens_hsa041462.10051015
17Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.01498670
18* Chemical carcinogenesis_Homo sapiens_hsa052041.99661133
19* Drug metabolism - other enzymes_Homo sapiens_hsa009831.94720142
20Staphylococcus aureus infection_Homo sapiens_hsa051501.93947935
21Histidine metabolism_Homo sapiens_hsa003401.85760321
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.82342863
23PPAR signaling pathway_Homo sapiens_hsa033201.70655114
24Folate biosynthesis_Homo sapiens_hsa007901.68891240
25Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.66727753
26Propanoate metabolism_Homo sapiens_hsa006401.65980074
27Retinol metabolism_Homo sapiens_hsa008301.64173256
28beta-Alanine metabolism_Homo sapiens_hsa004101.56899187
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.52835142
30Selenocompound metabolism_Homo sapiens_hsa004501.52743345
31Sulfur relay system_Homo sapiens_hsa041221.48058300
32Fatty acid metabolism_Homo sapiens_hsa012121.46273541
33Butanoate metabolism_Homo sapiens_hsa006501.41414769
34Starch and sucrose metabolism_Homo sapiens_hsa005001.38187603
35Sulfur metabolism_Homo sapiens_hsa009201.34119598
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.28882863
37Arachidonic acid metabolism_Homo sapiens_hsa005901.28260436
38Phenylalanine metabolism_Homo sapiens_hsa003601.26261545
39Fat digestion and absorption_Homo sapiens_hsa049751.25668569
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.24026181
41ABC transporters_Homo sapiens_hsa020101.19234561
42Bile secretion_Homo sapiens_hsa049761.17553193
43Tyrosine metabolism_Homo sapiens_hsa003501.14687240
442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.10881540
45Pyruvate metabolism_Homo sapiens_hsa006201.10698654
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.08111741
47Vitamin B6 metabolism_Homo sapiens_hsa007501.06981698
48One carbon pool by folate_Homo sapiens_hsa006701.06029201
49Biosynthesis of amino acids_Homo sapiens_hsa012301.05086642
50Carbon metabolism_Homo sapiens_hsa012001.03385694
51Vitamin digestion and absorption_Homo sapiens_hsa049771.01415121
52Fatty acid elongation_Homo sapiens_hsa000621.00637736
53Pentose phosphate pathway_Homo sapiens_hsa000300.96995990
54Glutathione metabolism_Homo sapiens_hsa004800.95855167
55Cyanoamino acid metabolism_Homo sapiens_hsa004600.94581326
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.93550667
57Maturity onset diabetes of the young_Homo sapiens_hsa049500.92601889
58Steroid biosynthesis_Homo sapiens_hsa001000.92307124
59Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.88175054
60Prion diseases_Homo sapiens_hsa050200.85713011
61Mineral absorption_Homo sapiens_hsa049780.76430200
62Primary immunodeficiency_Homo sapiens_hsa053400.73584635
63Arginine and proline metabolism_Homo sapiens_hsa003300.73125637
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70373359
65Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.57093716
66Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53459438
67Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.53175085
68Lysine degradation_Homo sapiens_hsa003100.52823094
69Ribosome_Homo sapiens_hsa030100.50695045
70Galactose metabolism_Homo sapiens_hsa000520.50241024
71Leishmaniasis_Homo sapiens_hsa051400.47667771
72Glycerolipid metabolism_Homo sapiens_hsa005610.46939274
73* Metabolic pathways_Homo sapiens_hsa011000.45619152
74Intestinal immune network for IgA production_Homo sapiens_hsa046720.44552302
75RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.43711792
76Protein digestion and absorption_Homo sapiens_hsa049740.42843272
77Legionellosis_Homo sapiens_hsa051340.38804884
78Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.38798820
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38415860
80Antigen processing and presentation_Homo sapiens_hsa046120.37825170
81NF-kappa B signaling pathway_Homo sapiens_hsa040640.37651438
82Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.37196567
83Measles_Homo sapiens_hsa051620.34615135
84Systemic lupus erythematosus_Homo sapiens_hsa053220.33939198
85Pyrimidine metabolism_Homo sapiens_hsa002400.33302949
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.30517013
87Allograft rejection_Homo sapiens_hsa053300.30434381
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29324993
89Adipocytokine signaling pathway_Homo sapiens_hsa049200.28850509
90Herpes simplex infection_Homo sapiens_hsa051680.27815003
91Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.26487262
92Linoleic acid metabolism_Homo sapiens_hsa005910.25118560
93Renin-angiotensin system_Homo sapiens_hsa046140.24216998
94Fructose and mannose metabolism_Homo sapiens_hsa000510.23135446
95Toll-like receptor signaling pathway_Homo sapiens_hsa046200.22900088
96Insulin resistance_Homo sapiens_hsa049310.21699149
97Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.20365473
98Pertussis_Homo sapiens_hsa051330.19722617
99DNA replication_Homo sapiens_hsa030300.19475964
100Hematopoietic cell lineage_Homo sapiens_hsa046400.19300476
101Proteasome_Homo sapiens_hsa030500.19115989
102Malaria_Homo sapiens_hsa051440.17952080
103Protein export_Homo sapiens_hsa030600.16397477
104Glycosaminoglycan degradation_Homo sapiens_hsa005310.15710891
105Other glycan degradation_Homo sapiens_hsa005110.15464382
106B cell receptor signaling pathway_Homo sapiens_hsa046620.14727071
107Graft-versus-host disease_Homo sapiens_hsa053320.13594747
108Sphingolipid metabolism_Homo sapiens_hsa006000.09250439
109Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.08084412
110Ether lipid metabolism_Homo sapiens_hsa005650.07621545
111Fatty acid biosynthesis_Homo sapiens_hsa000610.07505895
112Glucagon signaling pathway_Homo sapiens_hsa049220.06178205
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.05898274
114Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.2194359
115Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1801395
116African trypanosomiasis_Homo sapiens_hsa05143-0.1558914
117Amoebiasis_Homo sapiens_hsa05146-0.0876161
118Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512-0.0855738
119Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0768118
120AMPK signaling pathway_Homo sapiens_hsa04152-0.0638809
121Pancreatic secretion_Homo sapiens_hsa04972-0.0551518
122Serotonergic synapse_Homo sapiens_hsa04726-0.0068378

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