NAT6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the N-acetyltransferase family. N-acetyltransferases modify proteins by transferring acetyl groups from acetyl CoA to the N-termini of protein substrates. The encoded protein is a cytoplasmic N-acetyltransferase with a substrate specificity for proteins with an N-terminal methionine. This gene is located in the tumor suppressor gene region on chromosome 3p21.3 and the encoded protein may play a role in cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed. This gene overlaps and is on the same strand as hyaluronoglucosaminidase 3, and some transcripts of each gene share a portion of the first exon. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.27967676
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.27967676
3L-phenylalanine metabolic process (GO:0006558)6.19999588
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.19999588
5aromatic amino acid family catabolic process (GO:0009074)5.56870680
6glyoxylate metabolic process (GO:0046487)5.14593869
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.14297742
8indole-containing compound catabolic process (GO:0042436)5.08373851
9indolalkylamine catabolic process (GO:0046218)5.08373851
10tryptophan catabolic process (GO:0006569)5.08373851
11sulfur amino acid catabolic process (GO:0000098)5.07628191
12kynurenine metabolic process (GO:0070189)5.03194161
13negative regulation of erythrocyte differentiation (GO:0045647)4.95431979
14cysteine metabolic process (GO:0006534)4.89580346
15bile acid biosynthetic process (GO:0006699)4.89079551
16fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.86665415
17tryptophan metabolic process (GO:0006568)4.85175939
18alpha-linolenic acid metabolic process (GO:0036109)4.78266134
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.54362998
20positive regulation of B cell differentiation (GO:0045579)4.54089773
21lysine catabolic process (GO:0006554)4.53577451
22lysine metabolic process (GO:0006553)4.53577451
23urea metabolic process (GO:0019627)4.53576207
24urea cycle (GO:0000050)4.53576207
25positive regulation of gamma-delta T cell activation (GO:0046645)4.52802107
26high-density lipoprotein particle remodeling (GO:0034375)4.45025571
27amino-acid betaine metabolic process (GO:0006577)4.41343994
28peptidyl-glutamic acid carboxylation (GO:0017187)4.38944573
29protein carboxylation (GO:0018214)4.38944573
30complement activation, alternative pathway (GO:0006957)4.37765133
31deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.36963984
32negative regulation of fibrinolysis (GO:0051918)4.35124367
33response to pheromone (GO:0019236)4.29873420
34regulation of gamma-delta T cell differentiation (GO:0045586)4.27789823
35regulation of protein activation cascade (GO:2000257)4.22165288
36regulation of triglyceride catabolic process (GO:0010896)4.19382166
37regulation of cholesterol esterification (GO:0010872)4.18778550
38nitrogen cycle metabolic process (GO:0071941)4.16485737
39ethanol oxidation (GO:0006069)4.15543816
40aromatic amino acid family metabolic process (GO:0009072)4.13398196
41serine family amino acid catabolic process (GO:0009071)4.10248297
42tyrosine metabolic process (GO:0006570)4.09974720
43regulation of fibrinolysis (GO:0051917)4.08440642
44bile acid metabolic process (GO:0008206)4.04330591
45imidazole-containing compound metabolic process (GO:0052803)3.99976934
46phospholipid efflux (GO:0033700)3.97679975
47regulation of complement activation (GO:0030449)3.96617789
48coenzyme catabolic process (GO:0009109)3.95980290
49fusion of sperm to egg plasma membrane (GO:0007342)3.91123499
50alpha-amino acid catabolic process (GO:1901606)3.85711285
51sperm capacitation (GO:0048240)3.84920007
52reverse cholesterol transport (GO:0043691)3.78712218
53cofactor catabolic process (GO:0051187)3.77183758
54protein-lipid complex remodeling (GO:0034368)3.74700840
55macromolecular complex remodeling (GO:0034367)3.74700840
56plasma lipoprotein particle remodeling (GO:0034369)3.74700840
57carnitine metabolic process (GO:0009437)3.74329688
58NAD biosynthetic process (GO:0009435)3.73793863
59homocysteine metabolic process (GO:0050667)3.73174606
60sperm motility (GO:0030317)3.72800270
61glycine metabolic process (GO:0006544)3.72412809
62acylglycerol homeostasis (GO:0055090)3.72389485
63triglyceride homeostasis (GO:0070328)3.72389485
64negative regulation of sterol transport (GO:0032372)3.69126625
65negative regulation of cholesterol transport (GO:0032375)3.69126625
66ribosomal small subunit assembly (GO:0000028)3.66824474
67cellular modified amino acid catabolic process (GO:0042219)3.65943889
68serine family amino acid metabolic process (GO:0009069)3.65694193
69positive regulation of granulocyte differentiation (GO:0030854)3.65527927
70plasma lipoprotein particle clearance (GO:0034381)3.64817367
71negative thymic T cell selection (GO:0045060)3.64197453
72indolalkylamine metabolic process (GO:0006586)3.62851065
73cellular amino acid catabolic process (GO:0009063)3.61948757
74cellular biogenic amine catabolic process (GO:0042402)3.61777372
75amine catabolic process (GO:0009310)3.61777372
76negative regulation of granulocyte differentiation (GO:0030853)3.60714855
77pyridine nucleotide biosynthetic process (GO:0019363)3.59371469
78nicotinamide nucleotide biosynthetic process (GO:0019359)3.59371469
79benzene-containing compound metabolic process (GO:0042537)3.59326829
802-oxoglutarate metabolic process (GO:0006103)3.56398890
81valine metabolic process (GO:0006573)3.55945618
82aldehyde catabolic process (GO:0046185)3.54489541
83fatty acid beta-oxidation (GO:0006635)3.54063838
84negative regulation of cell killing (GO:0031342)3.53994316
85negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.53994316
86negative T cell selection (GO:0043383)3.51243954
87regulation of gamma-delta T cell activation (GO:0046643)3.51150811
88blood coagulation, intrinsic pathway (GO:0007597)3.50886074
89cellular glucuronidation (GO:0052695)3.47871958
90Arp2/3 complex-mediated actin nucleation (GO:0034314)3.46649541
91serine family amino acid biosynthetic process (GO:0009070)3.44360469
92regulation of granulocyte differentiation (GO:0030852)3.43817119
93fatty acid oxidation (GO:0019395)3.43337726
94pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.42005273
95positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.41550314
96bile acid and bile salt transport (GO:0015721)3.40048106
97carboxylic acid catabolic process (GO:0046395)3.38641651
98organic acid catabolic process (GO:0016054)3.38641651
99definitive hemopoiesis (GO:0060216)3.37934382
100response to nitrosative stress (GO:0051409)3.36359711
101lipid oxidation (GO:0034440)3.36146471
102primary alcohol catabolic process (GO:0034310)3.35095330
103cellular ketone body metabolic process (GO:0046950)3.34251300
104opsonization (GO:0008228)3.33619874
105thymic T cell selection (GO:0045061)3.32486901
106monocarboxylic acid catabolic process (GO:0072329)3.31885925
107fatty acid catabolic process (GO:0009062)3.31664046
108drug transmembrane transport (GO:0006855)3.30818843
109plasma lipoprotein particle assembly (GO:0034377)3.28625863
110arginine metabolic process (GO:0006525)3.27555608
111xenobiotic catabolic process (GO:0042178)3.26666258
112positive regulation of triglyceride lipase activity (GO:0061365)3.26166162
113positive regulation of lipoprotein lipase activity (GO:0051006)3.26166162
114acetyl-CoA metabolic process (GO:0006084)3.25545953
115mast cell degranulation (GO:0043303)3.24699234
116mast cell activation involved in immune response (GO:0002279)3.24699234
117glutamate metabolic process (GO:0006536)3.24576547
118cholesterol efflux (GO:0033344)3.24283312
119acrosome reaction (GO:0007340)3.23772718
120positive thymic T cell selection (GO:0045059)3.23479649
121regulation of B cell differentiation (GO:0045577)3.23234177
122regulation of cholesterol homeostasis (GO:2000188)3.23220341
123negative regulation of lipase activity (GO:0060192)3.21729032
124ethanol metabolic process (GO:0006067)3.21320354
125phosphatidylethanolamine biosynthetic process (GO:0006646)3.21086967
126aspartate family amino acid catabolic process (GO:0009068)3.20897382
127low-density lipoprotein particle remodeling (GO:0034374)3.20708593
128regulation of cholesterol metabolic process (GO:0090181)3.20639844
129viral transcription (GO:0019083)3.19510423
130short-chain fatty acid metabolic process (GO:0046459)3.18851496
131positive regulation of lipid catabolic process (GO:0050996)3.17371471
132mature B cell differentiation involved in immune response (GO:0002313)3.16318131
133negative regulation of DNA-templated transcription, elongation (GO:0032785)3.08366693
134ribosomal small subunit biogenesis (GO:0042274)2.98818957
135mast cell activation (GO:0045576)2.96157211
136regulation of mast cell degranulation (GO:0043304)2.94200455
137protoporphyrinogen IX metabolic process (GO:0046501)2.92682799
138rRNA modification (GO:0000154)2.92288566
139chromosome condensation (GO:0030261)2.91657758
140pyrimidine nucleotide catabolic process (GO:0006244)2.91374252
141rRNA methylation (GO:0031167)2.90205668
142negative regulation of B cell apoptotic process (GO:0002903)2.89816709
143protoporphyrinogen IX biosynthetic process (GO:0006782)2.89651942
144cell wall macromolecule metabolic process (GO:0044036)2.89465487
145translational termination (GO:0006415)2.88638978
146megakaryocyte development (GO:0035855)2.88458002
147microtubule severing (GO:0051013)2.87108352
148DNA packaging (GO:0006323)2.86927567
149response to peptidoglycan (GO:0032494)2.86651248
150UV protection (GO:0009650)2.84813883
151negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.84653870
152positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.84189497
153pentose metabolic process (GO:0019321)2.81560033
154phosphatidylethanolamine metabolic process (GO:0046337)2.78972076
155translational elongation (GO:0006414)2.78033878
156pinocytosis (GO:0006907)2.77125778
157plasma membrane fusion (GO:0045026)2.76964673
158immunoglobulin mediated immune response (GO:0016064)2.76500808
159leukocyte degranulation (GO:0043299)2.76339858
160sleep (GO:0030431)2.76118553
161response to interferon-beta (GO:0035456)2.75904329
162protein-DNA complex disassembly (GO:0032986)2.75086362
163nucleosome disassembly (GO:0006337)2.75086362
164actin nucleation (GO:0045010)2.75008128
165positive regulation of T cell mediated cytotoxicity (GO:0001916)2.74770131
166peptidyl-arginine omega-N-methylation (GO:0035247)2.72714772
167tolerance induction (GO:0002507)2.72500101
168homeostasis of number of cells within a tissue (GO:0048873)2.71855335
169response to muramyl dipeptide (GO:0032495)2.69288103
170deoxyribonucleotide catabolic process (GO:0009264)2.69235228
171spermatid development (GO:0007286)2.67849381
172protein maturation by protein folding (GO:0022417)2.66426737
173mitochondrial calcium ion transport (GO:0006851)2.66297420
174T cell selection (GO:0045058)2.66146175
175histone H4 deacetylation (GO:0070933)2.65944661
176positive regulation of interleukin-4 production (GO:0032753)2.64131409
177Peyers patch development (GO:0048541)2.63846407
178mucosal-associated lymphoid tissue development (GO:0048537)2.63846407
179sexual reproduction (GO:0019953)2.62353866
180cellular response to interferon-beta (GO:0035458)2.62303215
181G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.60057976
182regulation of mast cell activation involved in immune response (GO:0033006)2.59476553
183regulation of B cell receptor signaling pathway (GO:0050855)2.57483960
184GDP-mannose metabolic process (GO:0019673)2.57413496
185dosage compensation (GO:0007549)2.57326379
186negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.56513508
187deoxyribose phosphate catabolic process (GO:0046386)2.56197013
188autophagic vacuole fusion (GO:0000046)2.55602799
189intracellular estrogen receptor signaling pathway (GO:0030520)2.55573824
190regulation of myeloid leukocyte mediated immunity (GO:0002886)2.54114535
191regulation of T cell mediated cytotoxicity (GO:0001914)2.53577617
192lysosome localization (GO:0032418)2.51201539
193positive regulation of T cell cytokine production (GO:0002726)2.50235893
194leukocyte aggregation (GO:0070486)2.49094945
195viral life cycle (GO:0019058)2.48914672
196negative regulation of phagocytosis (GO:0050765)2.48454059
197pentose-phosphate shunt (GO:0006098)2.48211210
198protein complex disassembly (GO:0043241)2.47434271
199negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.47209898
200positive regulation of odontogenesis (GO:0042482)2.45847285

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.46885758
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.94004963
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.33583790
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.95147921
5EGR1_23403033_ChIP-Seq_LIVER_Mouse4.67761025
6LXR_22158963_ChIP-Seq_LIVER_Mouse4.34301634
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.04454467
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.85782031
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.33863973
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.44895677
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.37317721
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.29378188
13GATA1_22025678_ChIP-Seq_K562_Human2.25827890
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.12131700
15TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.11397096
16EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.03933110
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.95371659
18* UTX_26944678_Chip-Seq_JUKART_Human1.93428447
19KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.84560623
20VDR_24763502_ChIP-Seq_THP-1_Human1.79901235
21CIITA_25753668_ChIP-Seq_RAJI_Human1.78591498
22ELF1_17652178_ChIP-ChIP_JURKAT_Human1.68435221
23* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.68155624
24SA1_27219007_Chip-Seq_ERYTHROID_Human1.67821180
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.67062540
26KDM2B_26808549_Chip-Seq_DND41_Human1.65240801
27CTCF_27219007_Chip-Seq_ERYTHROID_Human1.58023525
28SCL_19346495_ChIP-Seq_HPC-7_Human1.56639635
29YY1_22570637_ChIP-Seq_MALME-3M_Human1.53866519
30STAT6_21828071_ChIP-Seq_BEAS2B_Human1.53701850
31TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.53503619
32E2F1_20622854_ChIP-Seq_HELA_Human1.52909473
33DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.51127644
34CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.50177962
35EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.49180961
36* PHF8_20622854_ChIP-Seq_HELA_Human1.48916723
37NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.48848903
38MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.48318552
39KDM2B_26808549_Chip-Seq_SUP-B15_Human1.45047122
40MYB_26560356_Chip-Seq_TH2_Human1.44839031
41RARG_19884340_ChIP-ChIP_MEFs_Mouse1.44656131
42TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43015175
43BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.41861840
44RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.41755283
45CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.41512585
46NCOR1_26117541_ChIP-Seq_K562_Human1.41127136
47THAP11_20581084_ChIP-Seq_MESCs_Mouse1.40632018
48XRN2_22483619_ChIP-Seq_HELA_Human1.39629123
49IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.37631604
50TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.37611227
51SMC4_20622854_ChIP-Seq_HELA_Human1.36614933
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.36568574
53SPI1_23547873_ChIP-Seq_NB4_Human1.34357047
54STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.31125496
55MYB_26560356_Chip-Seq_TH1_Human1.30201347
56KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.29177532
57* P300_27268052_Chip-Seq_Bcells_Human1.29171096
58GATA1_22383799_ChIP-Seq_G1ME_Mouse1.27788185
59STAT4_19710469_ChIP-ChIP_TH1__Mouse1.27592734
60* FOXP1_21924763_ChIP-Seq_HESCs_Human1.27313125
61LXR_22292898_ChIP-Seq_THP-1_Human1.26021343
62PU.1_20513432_ChIP-Seq_Bcells_Mouse1.25652124
63LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.25511894
64* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.23997735
65SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.21163834
66STAT3_1855785_ChIP-Seq_MESCs_Mouse1.21158659
67CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.21115673
68ETS1_20019798_ChIP-Seq_JURKAT_Human1.21043627
69* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.20967610
70CTCF_20526341_ChIP-Seq_ESCs_Human1.18481813
71PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.18157540
72IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.17107298
73FOXP3_21729870_ChIP-Seq_TREG_Human1.16477369
74CLOCK_20551151_ChIP-Seq_293T_Human1.16457003
75GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.15845406
76MYC_18555785_ChIP-Seq_MESCs_Mouse1.15355944
77GATA1_19941827_ChIP-Seq_MEL_Mouse1.14662234
78GABP_19822575_ChIP-Seq_HepG2_Human1.14502933
79ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.13826003
80* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13607220
81ETS1_21867929_ChIP-Seq_TH2_Mouse1.13130084
82RXRA_24833708_ChIP-Seq_LIVER_Mouse1.13109923
83BP1_19119308_ChIP-ChIP_Hs578T_Human1.12431548
84SPI1_23127762_ChIP-Seq_K562_Human1.11658846
85SRF_21415370_ChIP-Seq_HL-1_Mouse1.11514785
86MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.10783683
87VDR_21846776_ChIP-Seq_THP-1_Human1.10698721
88LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.09908087
89SA1_27219007_Chip-Seq_Bcells_Human1.09841914
90BRD4_27068464_Chip-Seq_AML-cells_Mouse1.09458772
91MYB_21317192_ChIP-Seq_ERMYB_Mouse1.09130543
92RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.08972544
93CTCF_18555785_ChIP-Seq_MESCs_Mouse1.05670285
94SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.05314931
95BCL6_27268052_Chip-Seq_Bcells_Human1.04230852
96TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.03072910
97* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.01857761
98TP63_17297297_ChIP-ChIP_HaCaT_Human1.01760754
99* BCOR_27268052_Chip-Seq_Bcells_Human1.01596254
100MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.98470402
101CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.97448644
102ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.96784976
103ZNF263_19887448_ChIP-Seq_K562_Human0.96590888
104TET1_21451524_ChIP-Seq_MESCs_Mouse0.95398318
105NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.94881759
106MYC_22102868_ChIP-Seq_BL_Human0.94293502
107STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.94171096
108MAF_26560356_Chip-Seq_TH1_Human0.93684193
109ELK3_25401928_ChIP-Seq_HUVEC_Human0.93191379
110GATA2_22383799_ChIP-Seq_G1ME_Mouse0.92136383
111ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91248733
112* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90726384
113* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.89524804
114CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.88256077
115NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.88078160
116SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.86727881
117GATA1_19941826_ChIP-Seq_K562_Human0.86185835
118MYC_18358816_ChIP-ChIP_MESCs_Mouse0.85715489
119RARA_24833708_ChIP-Seq_LIVER_Mouse0.84965905
120BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.83914164
121HNF4A_19822575_ChIP-Seq_HepG2_Human0.83016502
122IRF8_21731497_ChIP-ChIP_J774_Mouse0.82174855
123MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.81926137
124* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.81467202
125ELF1_20517297_ChIP-Seq_JURKAT_Human0.81234098
126RACK7_27058665_Chip-Seq_MCF-7_Human0.80883354
127CTCF_26484167_Chip-Seq_Bcells_Mouse0.80612727
128HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.78263435
129SRY_22984422_ChIP-ChIP_TESTIS_Rat0.78231945
130E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.78064340
131SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.77791728
132RARB_24833708_ChIP-Seq_LIVER_Mouse0.77374393
133PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.77324881
134SOX2_27498859_Chip-Seq_STOMACH_Mouse0.76849689
135CTCF_21964334_ChIP-Seq_BJAB-B_Human0.76152650
136TCF7_22412390_ChIP-Seq_EML_Mouse0.75536140
137CTCF_21964334_Chip-Seq_Bcells_Human0.75309870
138SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.74620345
139ERG_20887958_ChIP-Seq_HPC-7_Mouse0.73892682
140MAF_26560356_Chip-Seq_TH2_Human0.73795722
141JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.73699949
142* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.73541478
143SPI1_20517297_ChIP-Seq_HL60_Human0.73102012
144IRF8_27001747_Chip-Seq_BMDM_Mouse0.72948391
145P63_26484246_Chip-Seq_KERATINOCYTES_Human0.72859173
146CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.72581061
147RUNX1_22412390_ChIP-Seq_EML_Mouse0.72553438
148P68_20966046_ChIP-Seq_HELA_Human0.72477613
149RAD21_21589869_ChIP-Seq_MESCs_Mouse0.72008149

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.40858016
2MP0005360_urolithiasis5.74286580
3MP0005365_abnormal_bile_salt5.16460707
4MP0005085_abnormal_gallbladder_physiolo5.07941186
5MP0008875_abnormal_xenobiotic_pharmacok4.41232108
6MP0005410_abnormal_fertilization4.32536079
7MP0003806_abnormal_nucleotide_metabolis4.02685101
8MP0009840_abnormal_foam_cell3.34462917
9MP0003252_abnormal_bile_duct3.31540949
10MP0010329_abnormal_lipoprotein_level3.00287871
11MP0005083_abnormal_biliary_tract2.86586275
12MP0003763_abnormal_thymus_physiology2.79091704
13MP0003191_abnormal_cellular_cholesterol2.52809211
14MP0003656_abnormal_erythrocyte_physiolo2.51838517
15MP0009278_abnormal_bone_marrow2.47979446
16MP0005332_abnormal_amino_acid2.37148931
17MP0009333_abnormal_splenocyte_physiolog2.26891020
18MP0000465_gastrointestinal_hemorrhage2.21645065
19MP0002398_abnormal_bone_marrow2.16144701
20MP0003195_calcinosis2.06758771
21MP0000609_abnormal_liver_physiology2.05149324
22MP0001666_abnormal_nutrient_absorption2.00425740
23MP0002420_abnormal_adaptive_immunity1.98622278
24MP0001819_abnormal_immune_cell1.96461189
25MP0003172_abnormal_lysosome_physiology1.95308119
26MP0005000_abnormal_immune_tolerance1.95293161
27MP0005319_abnormal_enzyme/_coenzyme1.94303521
28MP0003186_abnormal_redox_activity1.91647374
29MP0002722_abnormal_immune_system1.91429505
30MP0002723_abnormal_immune_serum1.89371528
31MP0003303_peritoneal_inflammation1.88423670
32MP0005671_abnormal_response_to1.84284091
33MP0000703_abnormal_thymus_morphology1.83816810
34MP0004019_abnormal_vitamin_homeostasis1.82437957
35MP0002118_abnormal_lipid_homeostasis1.81622249
36MP0001873_stomach_inflammation1.74503072
37MP0000716_abnormal_immune_system1.74292033
38MP0002452_abnormal_antigen_presenting1.70597314
39MP0002429_abnormal_blood_cell1.68254748
40MP0005670_abnormal_white_adipose1.62979088
41MP0004808_abnormal_hematopoietic_stem1.60028002
42MP0001764_abnormal_homeostasis1.59298762
43MP0008260_abnormal_autophagy1.58794634
44MP0003300_gastrointestinal_ulcer1.58527112
45MP0005584_abnormal_enzyme/coenzyme_acti1.56909074
46MP0003866_abnormal_defecation1.55686410
47MP0009764_decreased_sensitivity_to1.53239790
48MP0003011_delayed_dark_adaptation1.52918134
49MP0002138_abnormal_hepatobiliary_system1.51024924
50MP0002148_abnormal_hypersensitivity_rea1.49615051
51MP0002405_respiratory_system_inflammati1.47192247
52MP0009643_abnormal_urine_homeostasis1.42777807
53MP0006036_abnormal_mitochondrial_physio1.40200583
54MP0000015_abnormal_ear_pigmentation1.37432423
55MP0000678_abnormal_parathyroid_gland1.31431576
56MP0001790_abnormal_immune_system1.28901537
57MP0005387_immune_system_phenotype1.28901537
58MP0002019_abnormal_tumor_incidence1.27689591
59MP0003698_abnormal_male_reproductive1.27374005
60MP0002132_abnormal_respiratory_system1.26684471
61MP0002254_reproductive_system_inflammat1.25688431
62MP0008469_abnormal_protein_level1.25641610
63MP0000598_abnormal_liver_morphology1.24569139
64MP0003868_abnormal_feces_composition1.24537265
65MP0005464_abnormal_platelet_physiology1.21565961
66MP0003436_decreased_susceptibility_to1.21116444
67MP0003724_increased_susceptibility_to1.20003454
68MP0001348_abnormal_lacrimal_gland1.19318616
69MP0005636_abnormal_mineral_homeostasis1.19098805
70MP0005377_hearing/vestibular/ear_phenot1.17162944
71MP0003878_abnormal_ear_physiology1.17162944
72MP0009763_increased_sensitivity_to1.12009711
73MP0005451_abnormal_body_composition1.11965749
74MP0001929_abnormal_gametogenesis1.11865431
75MP0001533_abnormal_skeleton_physiology1.10697900
76MP0000685_abnormal_immune_system1.09687015
77MP0005397_hematopoietic_system_phenotyp1.08279132
78MP0001545_abnormal_hematopoietic_system1.08279132
79MP0009697_abnormal_copulation1.07756808
80MP0004147_increased_porphyrin_level1.06590587
81MP0005408_hypopigmentation1.04725622
82MP0001835_abnormal_antigen_presentation1.00194902
83MP0005375_adipose_tissue_phenotype1.00002907
84MP0000681_abnormal_thyroid_gland0.98987504
85MP0009785_altered_susceptibility_to0.98890140
86MP0001853_heart_inflammation0.97559242
87MP0010368_abnormal_lymphatic_system0.93152368
88MP0004130_abnormal_muscle_cell0.91272818
89MP0005647_abnormal_sex_gland0.90160513
90MP0009642_abnormal_blood_homeostasis0.89795969
91MP0000313_abnormal_cell_death0.89363927
92MP0002396_abnormal_hematopoietic_system0.86212012
93MP0008874_decreased_physiological_sensi0.86122170
94MP0000858_altered_metastatic_potential0.85487306
95MP0003705_abnormal_hypodermis_morpholog0.84837001
96MP0002166_altered_tumor_susceptibility0.84355583
97MP0005025_abnormal_response_to0.82008754
98MP0005075_abnormal_melanosome_morpholog0.81862125
99MP0002822_catalepsy0.81839771
100MP0002060_abnormal_skin_morphology0.81641885
101MP0009765_abnormal_xenobiotic_induced0.79463528
102MP0004233_abnormal_muscle_weight0.78845545
103MP0000003_abnormal_adipose_tissue0.78689055
104MP0005376_homeostasis/metabolism_phenot0.77838558
105MP0005266_abnormal_metabolism0.77269450
106MP0002933_joint_inflammation0.76535584
107MP0008007_abnormal_cellular_replicative0.76471496
108MP0001765_abnormal_ion_homeostasis0.75676929
109MP0005334_abnormal_fat_pad0.74339938
110MP0006035_abnormal_mitochondrial_morpho0.73303026
111MP0004381_abnormal_hair_follicle0.72937949
112MP0002161_abnormal_fertility/fecundity0.71363545
113MP0005058_abnormal_lysosome_morphology0.71053915
114MP0001845_abnormal_inflammatory_respons0.71020132
115MP0001756_abnormal_urination0.70423371
116MP0006054_spinal_hemorrhage0.70377911
117MP0004947_skin_inflammation0.70324852
118MP0002419_abnormal_innate_immunity0.69546511
119MP0002136_abnormal_kidney_physiology0.68943328
120MP0005166_decreased_susceptibility_to0.68701507
121MP0005535_abnormal_body_temperature0.68211019
122MP0003786_premature_aging0.67698892
123MP0004782_abnormal_surfactant_physiolog0.66719713
124MP0001986_abnormal_taste_sensitivity0.66599412
125MP0002837_dystrophic_cardiac_calcinosis0.66209991
126MP0005220_abnormal_exocrine_pancreas0.65601314
127MP0000490_abnormal_crypts_of0.64870921
128MP0005084_abnormal_gallbladder_morpholo0.64138020
129MP0000343_altered_response_to0.63758177
130MP0009379_abnormal_foot_pigmentation0.62954152
131MP0005023_abnormal_wound_healing0.62862749
132MP0002078_abnormal_glucose_homeostasis0.62567418
133MP0000372_irregular_coat_pigmentation0.62045518
134MP0005666_abnormal_adipose_tissue0.61778320
135MP0002971_abnormal_brown_adipose0.61362362
136MP0004185_abnormal_adipocyte_glucose0.61244594
137MP0000358_abnormal_cell_content/0.60707262
138MP0003075_altered_response_to0.60026408
139MP0005174_abnormal_tail_pigmentation0.59773720
140MP0001663_abnormal_digestive_system0.59218270
141MP0009115_abnormal_fat_cell0.56989841
142MP0010155_abnormal_intestine_physiology0.56539378
143MP0009931_abnormal_skin_appearance0.55942356
144MP0006082_CNS_inflammation0.54912560
145MP0002098_abnormal_vibrissa_morphology0.54353926
146MP0002796_impaired_skin_barrier0.52543182
147MP0000689_abnormal_spleen_morphology0.50166497
148MP0002928_abnormal_bile_duct0.49984931
149MP0008873_increased_physiological_sensi0.49917735
150MP0003453_abnormal_keratinocyte_physiol0.49838271
151MP0002970_abnormal_white_adipose0.49121527
152MP0003638_abnormal_response/metabolism_0.48856581
153MP0001800_abnormal_humoral_immune0.47902234
154MP0002877_abnormal_melanocyte_morpholog0.47386938
155MP0000249_abnormal_blood_vessel0.46135462
156MP0000604_amyloidosis0.45764676
157MP0000371_diluted_coat_color0.45087469
158MP0002135_abnormal_kidney_morphology0.44243450
159MP0001243_abnormal_dermal_layer0.44024581

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.39269366
2Intrahepatic cholestasis (HP:0001406)5.63549977
3Abnormality of monocarboxylic acid metabolism (HP:0010996)5.41086272
4Deep venous thrombosis (HP:0002625)5.33733039
5Xanthomatosis (HP:0000991)5.11666681
6Prolonged partial thromboplastin time (HP:0003645)5.02042236
7Hyperlipoproteinemia (HP:0010980)4.55059270
8Hypobetalipoproteinemia (HP:0003563)4.52828827
9Severe visual impairment (HP:0001141)4.50064273
10Elevated erythrocyte sedimentation rate (HP:0003565)4.42143167
11Complement deficiency (HP:0004431)4.28194150
12Hyperammonemia (HP:0001987)4.15355083
13Seborrheic dermatitis (HP:0001051)4.09685509
14Hypertensive crisis (HP:0100735)4.08505553
15Thrombocytosis (HP:0001894)4.06223453
16Petechiae (HP:0000967)4.02324292
17Obstructive lung disease (HP:0006536)4.01518321
18Chronic obstructive pulmonary disease (HP:0006510)4.01518321
19Ketosis (HP:0001946)4.01123953
20Abnormality of fatty-acid metabolism (HP:0004359)3.90083317
21Joint hemorrhage (HP:0005261)3.85786592
22Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.81174058
23Hyperglycinuria (HP:0003108)3.68551082
24Hypolipoproteinemia (HP:0010981)3.59654426
25Hyperbilirubinemia (HP:0002904)3.54155272
26Hypoglycemic coma (HP:0001325)3.48277789
27Abnormality of glutamine family amino acid metabolism (HP:0010902)3.47649016
28Hypoalphalipoproteinemia (HP:0003233)3.42083156
29Abnormality of the common coagulation pathway (HP:0010990)3.41647573
30Abnormality of sulfur amino acid metabolism (HP:0004339)3.39290255
31Hyperglycinemia (HP:0002154)3.36887763
32Abnormality of complement system (HP:0005339)3.34290819
33Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.33851496
34Abnormality of glycine metabolism (HP:0010895)3.33473038
35Abnormality of serine family amino acid metabolism (HP:0010894)3.33473038
36Abnormality of methionine metabolism (HP:0010901)3.28625230
37Hypercholesterolemia (HP:0003124)3.24496364
38Abnormality of aspartate family amino acid metabolism (HP:0010899)3.23895991
39Fat malabsorption (HP:0002630)3.22179034
40Abnormality of pyrimidine metabolism (HP:0004353)3.21058199
41Hyperthyroidism (HP:0000836)3.21027604
42Epidermoid cyst (HP:0200040)3.21023201
43Abnormality of the intrinsic pathway (HP:0010989)3.19297601
44Rhabdomyolysis (HP:0003201)3.14292775
45Fatigue (HP:0012378)3.10490905
46Abnormality of T cell physiology (HP:0011840)3.05255875
47Ketoacidosis (HP:0001993)2.98934820
48Dicarboxylic aciduria (HP:0003215)2.98892203
49Abnormality of dicarboxylic acid metabolism (HP:0010995)2.98892203
50Ragged-red muscle fibers (HP:0003200)2.98282015
51Truncus arteriosus (HP:0001660)2.95589779
52Myositis (HP:0100614)2.91794724
53Cerebral palsy (HP:0100021)2.91204008
54Abnormality of the heme biosynthetic pathway (HP:0010472)2.90845768
55Generalized aminoaciduria (HP:0002909)2.87307922
56Panhypogammaglobulinemia (HP:0003139)2.85015657
57Systemic lupus erythematosus (HP:0002725)2.80413567
58Delayed CNS myelination (HP:0002188)2.77454082
59Abnormality of nucleobase metabolism (HP:0010932)2.77149567
60Metabolic acidosis (HP:0001942)2.69937713
61Renal Fanconi syndrome (HP:0001994)2.69283572
62Agammaglobulinemia (HP:0004432)2.68123907
63Granulocytopenia (HP:0001913)2.65552509
64Steatorrhea (HP:0002570)2.64880709
65Myocardial infarction (HP:0001658)2.63663253
66Increased intramyocellular lipid droplets (HP:0012240)2.60643332
67Muscle fiber atrophy (HP:0100295)2.60457788
68Hepatocellular carcinoma (HP:0001402)2.60189871
69Chest pain (HP:0100749)2.58985381
70Abnormal number of erythroid precursors (HP:0012131)2.55308390
71Abnormality of purine metabolism (HP:0004352)2.55195251
72Amyloidosis (HP:0011034)2.54949289
73Abnormality of cells of the erythroid lineage (HP:0012130)2.54132872
74Aplasia/Hypoplasia of the thymus (HP:0010515)2.52528006
75Lethargy (HP:0001254)2.52120970
76Abnormality of reticulocytes (HP:0004312)2.48935738
77Gastrointestinal inflammation (HP:0004386)2.48491488
78Abnormality of serum amino acid levels (HP:0003112)2.47833339
79Poikilocytosis (HP:0004447)2.46975755
80Increased serum ferritin (HP:0003281)2.44247256
81Abnormality of iron homeostasis (HP:0011031)2.43972612
82Cholelithiasis (HP:0001081)2.43607076
83Atelectasis (HP:0100750)2.42213630
84Gingival bleeding (HP:0000225)2.41646740
85Abnormality of T cells (HP:0002843)2.41180427
86Abnormal gallbladder morphology (HP:0012437)2.35774552
87Spontaneous abortion (HP:0005268)2.34962171
88Abnormal gallbladder physiology (HP:0012438)2.34950296
89Cholecystitis (HP:0001082)2.34950296
90Myopathic facies (HP:0002058)2.34382230
91Gout (HP:0001997)2.34086861
92Abnormal delayed hypersensitivity skin test (HP:0002963)2.33482411
93Brushfield spots (HP:0001088)2.33139738
94Tubulointerstitial nephritis (HP:0001970)2.32916185
95Menorrhagia (HP:0000132)2.32709955
96Meningitis (HP:0001287)2.30922248
97Abnormality of transition element cation homeostasis (HP:0011030)2.30854298
98Cerebral edema (HP:0002181)2.30691615
99Spastic paraparesis (HP:0002313)2.30354461
100Progressive muscle weakness (HP:0003323)2.29579941
101Increased IgM level (HP:0003496)2.29523715
102Conjugated hyperbilirubinemia (HP:0002908)2.29066632
103Hepatosplenomegaly (HP:0001433)2.27742578
104Aplastic anemia (HP:0001915)2.27120401
105Polycythemia (HP:0001901)2.26325473
106Late onset (HP:0003584)2.25738722
107Cellulitis (HP:0100658)2.24219242
108Epistaxis (HP:0000421)2.22752045
109Hypertriglyceridemia (HP:0002155)2.21002524
110Malnutrition (HP:0004395)2.20802782
111Stomatitis (HP:0010280)2.20011029
112Acanthocytosis (HP:0001927)2.19906683
113Vomiting (HP:0002013)2.19870537
114Spastic diplegia (HP:0001264)2.19622596
115Inflammation of the large intestine (HP:0002037)2.19408111
116Asymmetric septal hypertrophy (HP:0001670)2.18953826
117Recurrent abscess formation (HP:0002722)2.18040878
118Abnormal rod and cone electroretinograms (HP:0008323)2.17967459
119Reticulocytosis (HP:0001923)2.17891054
120Ileus (HP:0002595)2.16629427
121Nausea (HP:0002018)2.16415070
122Hepatic necrosis (HP:0002605)2.15875651
123Recurrent gram-negative bacterial infections (HP:0005420)2.14123866
124Easy fatigability (HP:0003388)2.12681801
125Opisthotonus (HP:0002179)2.12105729
126Glomerulonephritis (HP:0000099)2.11750833
127Attenuation of retinal blood vessels (HP:0007843)2.11381638
128Vascular calcification (HP:0004934)2.10938387
129Pustule (HP:0200039)2.10514853
130Pulmonary fibrosis (HP:0002206)2.08944251
131Recurrent fungal infections (HP:0002841)2.08893125
132Centrally nucleated skeletal muscle fibers (HP:0003687)2.06424809
133Neonatal onset (HP:0003623)2.06141814
134Reduced antithrombin III activity (HP:0001976)2.04964292
135Abnormality of the prostate (HP:0008775)2.04911461
136Prolonged neonatal jaundice (HP:0006579)2.03977414
137Mitral stenosis (HP:0001718)2.03566470
138Slow saccadic eye movements (HP:0000514)2.02830605
139Elevated hepatic transaminases (HP:0002910)2.02653290
140Hypoparathyroidism (HP:0000829)2.02640697
141Esophageal varix (HP:0002040)2.02616097
142Thrombophlebitis (HP:0004418)2.02009006
143Exercise-induced myalgia (HP:0003738)2.01894840
144Gastrointestinal infarctions (HP:0005244)2.01834698
145Pallor (HP:0000980)2.01000607
146Prolonged bleeding time (HP:0003010)2.00851642
147Hepatocellular necrosis (HP:0001404)2.00477504
148Abnormality of the gallbladder (HP:0005264)1.99384006
149Pancreatitis (HP:0001733)1.99372320
150Type 2 muscle fiber atrophy (HP:0003554)1.99337234
151Aplasia/Hypoplasia of the earlobes (HP:0009906)1.99136972
152Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.97526760
153Hemorrhage of the eye (HP:0011885)1.97401197
154Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.94756828
155Vasculitis (HP:0002633)1.92399677
156Hypochromic microcytic anemia (HP:0004840)1.91982068
157Hypochromic anemia (HP:0001931)1.91129040
158Skin nodule (HP:0200036)1.90251410
159Paralysis (HP:0003470)1.88485408
160Myoglobinuria (HP:0002913)1.87492493
161Abnormal platelet function (HP:0011869)1.87400474
162Impaired platelet aggregation (HP:0003540)1.87400474
163Increased muscle lipid content (HP:0009058)1.87132120
164Progressive microcephaly (HP:0000253)1.87052430
165Acute lymphatic leukemia (HP:0006721)1.87035440
166Muscle stiffness (HP:0003552)1.86456487
167Acute hepatic failure (HP:0006554)1.86046610
168Severe combined immunodeficiency (HP:0004430)1.85895649
169Cardiovascular calcification (HP:0011915)1.85086280
170Irritability (HP:0000737)1.84842312
171Hypergonadotropic hypogonadism (HP:0000815)1.83909589
172Purpura (HP:0000979)1.83468949
173Growth hormone excess (HP:0000845)1.81820221
174Recurrent viral infections (HP:0004429)1.81371237
175Hypoglycemic seizures (HP:0002173)1.81196504
176Abnormality of B cell number (HP:0010975)1.80351360
177Eczematoid dermatitis (HP:0000976)1.79585466
178Microvesicular hepatic steatosis (HP:0001414)1.77472099
179Hypergammaglobulinemia (HP:0010702)1.77100788
180Abnormality of the tricuspid valve (HP:0001702)1.76836600
181Joint swelling (HP:0001386)1.76319814
182Thoracic kyphosis (HP:0002942)1.76006537

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.17113465
2ERN15.10158134
3TESK24.03128404
4SIK12.70355874
5CDK192.65139317
6FGFR42.42709148
7TRIB32.39198666
8FLT32.34377516
9TNK22.23517324
10MAP3K102.19442805
11TXK2.17837188
12FES2.15678542
13TYK22.07421704
14VRK22.06160048
15MAP2K32.05546158
16TBK11.94679968
17NME21.91376604
18RIPK41.89783490
19STK161.88987302
20MAP3K31.87327208
21KIT1.85116812
22PIM21.84985306
23TAOK31.82677934
24TGFBR21.81129226
25KDR1.72246529
26MST1R1.67210642
27PKN21.66538720
28INSRR1.58995353
29MAP4K21.58802371
30SIK21.50412155
31MAPK111.50302106
32MAPKAPK31.45971195
33MAP3K131.43251527
34MAP4K11.41829323
35IRAK31.41484839
36ARAF1.40634465
37BTK1.36920768
38PRPF4B1.30928235
39PLK41.23716537
40PRKD31.23598221
41MAP3K111.21927164
42IKBKE1.21850714
43CDK121.16883528
44EEF2K1.15509591
45MYLK1.12822596
46PASK1.11599369
47LMTK21.10284852
48ABL21.10041316
49EPHA31.08163064
50IKBKB1.04971754
51TIE11.03979054
52SMG11.00796117
53ZAP700.97100850
54CSF1R0.94107025
55TEC0.93892972
56MAPK40.92955121
57LRRK20.92620123
58PDPK10.92292606
59NEK90.92078563
60MAP3K10.91746265
61HCK0.91721647
62DYRK1B0.91236676
63RPS6KB20.90657248
64PDK10.90440083
65ICK0.89269841
66JAK20.89098094
67STK380.88355782
68MAP2K60.86432942
69MARK20.86315035
70PIK3CG0.85209024
71JAK30.83721747
72LCK0.81476814
73MAP3K140.80133839
74MAP3K70.79815352
75TGFBR10.78673052
76PRKD20.78630070
77MAPK120.78567963
78TESK10.76705884
79MATK0.76384613
80PDK40.76084833
81PDK30.76084833
82BMX0.74209173
83STK40.72020736
84TTN0.71560979
85PTK60.71505856
86SCYL20.69559183
87PINK10.69357738
88MAP3K60.66574019
89MAPK150.65938994
90GRK60.62548825
91PRKAA20.62254842
92CDK40.61250958
93PRKCQ0.61035210
94JAK10.60996482
95CDK60.59948483
96HIPK20.59660166
97PIM10.58335657
98SYK0.58273758
99ERBB20.58105381
100RPS6KA20.56275248
101PAK40.55536712
102CAMKK10.54938253
103NLK0.54463672
104RIPK10.52847519
105CSK0.52512277
106MARK30.51146770
107CHUK0.51093786
108MAP3K80.50236715
109IRAK40.49996931
110STK100.48627352
111SIK30.48114725
112DYRK30.48061350
113ILK0.47562542
114RPS6KA60.47533411
115TRPM70.45544333
116RPS6KL10.44938330
117RPS6KC10.44938330
118MAP2K40.44712560
119BRD40.43671887
120RPS6KA40.43313029
121MAP2K20.42949207
122TAOK20.42897657
123DAPK10.41916617
124DDR20.41550401
125CDK90.40742373
126MUSK0.40498155
127CCNB10.40360771
128LYN0.39191192
129EPHB20.37885766
130ERBB40.37418628
131PRKG20.36797730
132MTOR0.36659566
133CDK70.35481720
134RPS6KA10.35174574
135BLK0.35157123
136AURKA0.35021073
137ATR0.34548777
138MAPK30.34267036
139GRK70.32896989
140VRK10.32639965
141PRKCD0.31899414
142ACVR1B0.31437626
143PRKACG0.29870384
144WEE10.28231482
145ITK0.28151886

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.94202354
2Primary immunodeficiency_Homo sapiens_hsa053403.62536023
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.15609152
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.92659529
5Fatty acid degradation_Homo sapiens_hsa000712.66066348
6Pentose and glucuronate interconversions_Homo sapiens_hsa000402.56475326
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.44922754
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.42079144
9Arginine biosynthesis_Homo sapiens_hsa002202.41491271
10Tryptophan metabolism_Homo sapiens_hsa003802.40204172
11Complement and coagulation cascades_Homo sapiens_hsa046102.30769987
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.29061784
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.18155567
14Peroxisome_Homo sapiens_hsa041462.13681900
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.10378434
16Allograft rejection_Homo sapiens_hsa053302.03402602
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.02003414
18Propanoate metabolism_Homo sapiens_hsa006401.99219464
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.97022747
20Autoimmune thyroid disease_Homo sapiens_hsa053201.96316513
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.95393360
22Nitrogen metabolism_Homo sapiens_hsa009101.94885255
23Chemical carcinogenesis_Homo sapiens_hsa052041.93689236
24Caffeine metabolism_Homo sapiens_hsa002321.86723946
25Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.86438239
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.85893282
27PPAR signaling pathway_Homo sapiens_hsa033201.85219916
28beta-Alanine metabolism_Homo sapiens_hsa004101.85164489
29Fatty acid metabolism_Homo sapiens_hsa012121.83538414
30Histidine metabolism_Homo sapiens_hsa003401.83518314
31Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.82287127
32Graft-versus-host disease_Homo sapiens_hsa053321.81562112
33Antigen processing and presentation_Homo sapiens_hsa046121.80108338
34B cell receptor signaling pathway_Homo sapiens_hsa046621.75892665
35Hematopoietic cell lineage_Homo sapiens_hsa046401.72902487
36Sulfur relay system_Homo sapiens_hsa041221.71046992
37Staphylococcus aureus infection_Homo sapiens_hsa051501.67332942
38Steroid hormone biosynthesis_Homo sapiens_hsa001401.67325016
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.66923374
40T cell receptor signaling pathway_Homo sapiens_hsa046601.66385456
41Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.63652303
42Butanoate metabolism_Homo sapiens_hsa006501.61987612
43Retinol metabolism_Homo sapiens_hsa008301.59326520
44Folate biosynthesis_Homo sapiens_hsa007901.57587839
45Selenocompound metabolism_Homo sapiens_hsa004501.56255008
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.55765732
47Phenylalanine metabolism_Homo sapiens_hsa003601.55410901
48Pyruvate metabolism_Homo sapiens_hsa006201.49028479
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.45718592
50Starch and sucrose metabolism_Homo sapiens_hsa005001.41180293
51Tyrosine metabolism_Homo sapiens_hsa003501.40397607
52Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.39692907
53Carbon metabolism_Homo sapiens_hsa012001.34394244
54Osteoclast differentiation_Homo sapiens_hsa043801.33624936
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.32789157
56Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.31834861
57Non-small cell lung cancer_Homo sapiens_hsa052231.29837086
58Fatty acid elongation_Homo sapiens_hsa000621.28443190
59NF-kappa B signaling pathway_Homo sapiens_hsa040641.26744064
60Biosynthesis of amino acids_Homo sapiens_hsa012301.25867999
61Measles_Homo sapiens_hsa051621.23561020
62Viral myocarditis_Homo sapiens_hsa054161.21084055
63ABC transporters_Homo sapiens_hsa020101.19457368
64Sulfur metabolism_Homo sapiens_hsa009201.19084945
65Cyanoamino acid metabolism_Homo sapiens_hsa004601.16987695
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.16826497
67Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.16564405
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.14829680
69Platelet activation_Homo sapiens_hsa046111.13436764
70Bile secretion_Homo sapiens_hsa049761.12854923
71Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.07630711
72Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.06914318
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.05049891
74Type I diabetes mellitus_Homo sapiens_hsa049401.04457687
75Jak-STAT signaling pathway_Homo sapiens_hsa046301.02494578
76Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.00560280
77Fat digestion and absorption_Homo sapiens_hsa049750.98426723
78Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.97701153
79One carbon pool by folate_Homo sapiens_hsa006700.97268136
80Endocytosis_Homo sapiens_hsa041440.97256797
81Arginine and proline metabolism_Homo sapiens_hsa003300.97099651
82Nucleotide excision repair_Homo sapiens_hsa034200.94932496
83Glutathione metabolism_Homo sapiens_hsa004800.94013188
84VEGF signaling pathway_Homo sapiens_hsa043700.93759608
85Asthma_Homo sapiens_hsa053100.90279543
86Pentose phosphate pathway_Homo sapiens_hsa000300.90067545
87Purine metabolism_Homo sapiens_hsa002300.89810140
88Influenza A_Homo sapiens_hsa051640.89655440
89Epstein-Barr virus infection_Homo sapiens_hsa051690.89030919
90Chronic myeloid leukemia_Homo sapiens_hsa052200.88579365
91Shigellosis_Homo sapiens_hsa051310.82532985
92Viral carcinogenesis_Homo sapiens_hsa052030.82486362
93Vitamin digestion and absorption_Homo sapiens_hsa049770.80939171
94Maturity onset diabetes of the young_Homo sapiens_hsa049500.76327408
95Spliceosome_Homo sapiens_hsa030400.75306070
96Lysine degradation_Homo sapiens_hsa003100.75206158
97HTLV-I infection_Homo sapiens_hsa051660.74857261
98Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.73962059
99RNA transport_Homo sapiens_hsa030130.73125785
100Hepatitis B_Homo sapiens_hsa051610.72945775
101TNF signaling pathway_Homo sapiens_hsa046680.71259891
102Galactose metabolism_Homo sapiens_hsa000520.70612417
103Steroid biosynthesis_Homo sapiens_hsa001000.69407319
104Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69357999
105mTOR signaling pathway_Homo sapiens_hsa041500.65090677
106SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64168249
107RNA polymerase_Homo sapiens_hsa030200.63874185
108Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.63593093
109Mismatch repair_Homo sapiens_hsa034300.61956328
110Fructose and mannose metabolism_Homo sapiens_hsa000510.59868648
111Tuberculosis_Homo sapiens_hsa051520.58487765
112Toxoplasmosis_Homo sapiens_hsa051450.58388933
113Apoptosis_Homo sapiens_hsa042100.57364285
114Glycerolipid metabolism_Homo sapiens_hsa005610.57011760
115Metabolic pathways_Homo sapiens_hsa011000.56643779
116Inositol phosphate metabolism_Homo sapiens_hsa005620.55008471
117Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53478920
118NOD-like receptor signaling pathway_Homo sapiens_hsa046210.53026085
119Pancreatic cancer_Homo sapiens_hsa052120.52670723
120Parkinsons disease_Homo sapiens_hsa050120.50252802
121Vitamin B6 metabolism_Homo sapiens_hsa007500.49529736
122Homologous recombination_Homo sapiens_hsa034400.46744183
123Adipocytokine signaling pathway_Homo sapiens_hsa049200.42426170
124Ribosome_Homo sapiens_hsa030100.42010793
125Regulation of autophagy_Homo sapiens_hsa041400.41171342
126Fatty acid biosynthesis_Homo sapiens_hsa000610.40771922
127Glycosaminoglycan degradation_Homo sapiens_hsa005310.40057601
128Olfactory transduction_Homo sapiens_hsa047400.39801726
129Hepatitis C_Homo sapiens_hsa051600.38169320
130Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.37308460
131N-Glycan biosynthesis_Homo sapiens_hsa005100.36752546
132Huntingtons disease_Homo sapiens_hsa050160.35588012
133Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.34454886
134alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33881087
135Bladder cancer_Homo sapiens_hsa052190.32973414
136African trypanosomiasis_Homo sapiens_hsa051430.32223364
137Chemokine signaling pathway_Homo sapiens_hsa040620.31205380
138Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.29769333
139Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.28140962
140Insulin resistance_Homo sapiens_hsa049310.27665816
141Linoleic acid metabolism_Homo sapiens_hsa005910.26528720
142Pyrimidine metabolism_Homo sapiens_hsa002400.22014122
143DNA replication_Homo sapiens_hsa030300.21769196
144RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.20734381
145Other glycan degradation_Homo sapiens_hsa005110.20158764
146Renin-angiotensin system_Homo sapiens_hsa046140.17384412
147Legionellosis_Homo sapiens_hsa051340.16893132
148Prion diseases_Homo sapiens_hsa050200.14209254
149Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.11710947
150Arachidonic acid metabolism_Homo sapiens_hsa005900.11373185
151Base excision repair_Homo sapiens_hsa034100.03750402
152AMPK signaling pathway_Homo sapiens_hsa041520.01597420
153Leishmaniasis_Homo sapiens_hsa051400.01408288
154Acute myeloid leukemia_Homo sapiens_hsa052210.00688009
155Herpes simplex infection_Homo sapiens_hsa05168-0.0484916
156Malaria_Homo sapiens_hsa05144-0.0481972
157Toll-like receptor signaling pathway_Homo sapiens_hsa04620-0.0460422
158Glucagon signaling pathway_Homo sapiens_hsa04922-0.0288821
159Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.0288531
160Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0285302
161Lysosome_Homo sapiens_hsa04142-0.0267890
162Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533-0.0085373
163Intestinal immune network for IgA production_Homo sapiens_hsa04672-0.0063764

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